Involved in ionization of N3 of dUMP, leading to its activation
AMP-activated protein kinase glycogen-binding
Myo-inositol-1-phosphate synthase GAPDH-like
Secretion system C-terminal sorting domain-containing protein
Fibronectin type-III domain-containing protein
Chromosomal replication initiator DnaA C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Proton acceptor; for glutaminase activity
NADH-ubiquinone oxidoreductase 51kDa subunit FMN-binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Major facilitator superfamily (MFS) profile
Pyruvate phosphate dikinase AMP/ATP-binding
Tryptophan synthase beta chain-like PALP
Polysaccharide biosynthesis protein C-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Outer membrane protein beta-barrel domain-containing protein
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
UDP N-acetylglucosamine O-acyltransferase C-terminal
Cytochrome b/b6 N-terminal region profile
Type I restriction modification DNA specificity
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Pyruvate dehydrogenase E1 component middle
Activator of Hsp90 ATPase homologue 1-like C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Organic solvent tolerance-like N-terminal
RNA polymerase sigma factor 70 region 4 type 2
RND efflux pump membrane fusion protein barrel-sandwich
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
Beta-hexosaminidase bacterial type N-terminal
Carboxypeptidase regulatory-like domain-containing protein
NAD(P) transhydrogenase alpha subunit C-terminal
TonB-dependent receptor-like beta-barrel
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Putative regulatory protein FmdB Zinc ribbon
Carbamoyl-phosphate synthase small subunit N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Phosphotransferase system enzyme I N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Flagellar motor switch protein FliN-like C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Pseudouridine synthase I TruA alpha/beta
Positions MEP for the nucleophilic attack
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
6-phosphogluconate dehydrogenase C-terminal
Membrane iron-sulfur containing protein FtrD-like
SUF system FeS cluster assembly SufBD N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
O-(5'-phospho-DNA)-tyrosine intermediate
Glycosyl hydrolase family 30 beta sandwich
Dinitrogenase iron-molybdenum cofactor biosynthesis
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
N-acetylneuraminic acid synthase N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Phosphoribosylformylglycinamidine synthase linker
Cell wall-active antibiotics response LiaF-like C-terminal
Important for interaction with partner proteins
Peptidase M1 membrane alanine aminopeptidase
Inner membrane protein YgaP-like transmembrane
Cellulose-binding Sde182 nucleoside hydrolase-like
Cellulose-binding Sde182 nucleoside hydrolase-like domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Glycosyl transferase family 3 N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Aminoacyl-transfer RNA synthetases class-II family profile
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glycosyl-hydrolase 97 C-terminal oligomerisation
YbaK/aminoacyl-tRNA synthetase-associated
Outer membrane lipoprotein-sorting protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Polymerase/histidinol phosphatase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Peptidase S9 prolyl oligopeptidase catalytic
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Urease accessory protein UreH-like transmembrane
Membrane fusion protein biotin-lipoyl like
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Could play a key role in the communication between the regulatory and the substrate sites
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Yeast cell wall synthesis Kre9/Knh1-like N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Putative auto-transporter adhesin head GIN
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Anthranilate synthase component I N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Flagellar assembly protein FliH/Type III secretion system HrpE
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Soluble ligand binding domain-containing protein
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Polysaccharide chain length determinant N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Mandelate racemase/muconate lactonizing enzyme C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Alginate export domain-containing protein
Thiamin pyrophosphokinase thiamin-binding
Penicillin-binding protein transpeptidase
Gliding motility protein SprA N-terminal
Trigger factor ribosome-binding bacterial
Transposase IS116/IS110/IS902 C-terminal
Bacterial type II secretion system protein E
Ion-translocating oxidoreductase complex subunit G
RlpA-like protein double-psi beta-barrel
Survival protein SurE-like phosphatase/nucleotidase
Gly-cisPro motif, important for rejection of L-amino acids
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Lysidine-tRNA(Ile) synthetase C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Signal transduction histidine kinase internal region
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
N6 adenine-specific DNA methyltransferase N-terminal
Large ribosomal subunit protein uL15/eL18
ATP-grasp fold succinyl-CoA synthetase-type
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
RNA binding; important for wobble base 34 recognition
Alpha galactosidase C-terminal beta sandwich
Alanyl-transfer RNA synthetases family profile
ATP synthase F1 complex delta/epsilon subunit N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
O-(3'-phospho-DNA)-tyrosine intermediate
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Outer membrane lipoprotein BamD-like domain-containing protein
Ribosomal RNA adenine methylase transferase N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Prokaryotic-type class I peptide chain release factors
NIF system FeS cluster assembly NifU C-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Heavy metal binding domain-containing protein
Translation elongation factor P/YeiP central
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Flagellar hook-length control protein-like C-terminal
Heme-copper oxidase subunit III family profile
Schiff-base intermediate with acetaldehyde
Alpha-D-phosphohexomutase alpha/beta/alpha
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Large ribosomal subunit protein uL6 alpha-beta
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glucosamine/galactosamine-6-phosphate isomerase
Glycoside hydrolase family 42 N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Glycine cleavage T-protein C-terminal barrel
Polysaccharide biosynthesis protein CapD-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glycoside hydrolase family 31 N-terminal
Reversibly protonated during proton transport
Phosphoadenosine phosphosulphate reductase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Nitrite/Sulfite reductase ferredoxin-like
Gamma-butyrobetaine hydroxylase-like N-terminal
FlgD/Vpr Ig-like domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate
Erythronate-4-phosphate dehydrogenase dimerisation
Could be important to modulate the pK values of the two catalytic cysteine residues
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Helix-hairpin-helix DNA-binding motif class 1
Large ribosomal subunit protein uL30-like ferredoxin-like fold
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Alpha-glycerophosphate oxidase C-terminal
Nucleophile; cysteine thiosulfonate intermediate
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
DNA replication/recombination mediator RecO N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Phage terminase large subunit GpA ATPase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
DNA mismatch repair proteins mutS family
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
T9SS type A sorting domain-containing protein
NADH:ubiquinone oxidoreductase 30kDa subunit
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Large ribosomal subunit protein uL2 C-terminal
Plays an important role in substrate specificity
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
Release factor glutamine methyltransferase N-terminal
DNA-directed DNA polymerase family A palm
Non-canonical purine NTP phosphatase/PRRC1
Ferrous iron transport protein B C-terminal
Lipocalin-like domain-containing protein
RNA 2-O ribose methyltransferase substrate binding
Periplasmic copper-binding protein NosD beta helix