Major facilitator superfamily (MFS) profile
6-phosphogluconate dehydrogenase C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Cytochrome oxidase subunit II copper A binding
Release factor glutamine methyltransferase N-terminal
Alpha-L-glutamate ligase-related protein ATP-grasp
Gfo/Idh/MocA-like oxidoreductase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Anthranilate synthase component I N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
SMODS-associating 2TM beta-strand rich effector
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Solute-binding protein family 3/N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Polysaccharide chain length determinant N-terminal
Prokaryotic-type class I peptide chain release factors
Positions MEP for the nucleophilic attack
Phosphatidic acid phosphatase type 2/haloperoxidase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
ABC-type glycine betaine transport system substrate-binding
Bacterial DNA polymerase III alpha subunit NTPase
DNA polymerase helix-hairpin-helix motif
Aminoacyl-transfer RNA synthetases class-II family profile
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Membrane insertase YidC/Oxa/ALB C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Tryptophan synthase beta chain-like PALP
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Peptide methionine sulphoxide reductase MsrA
Intracellular proteinase inhibitor BsuPI
Ribulose bisphosphate carboxylase large subunit C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Cell envelope-related transcriptional attenuator
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
NIF system FeS cluster assembly NifU N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Sporulation transcription regulator WhiA N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
O-(5'-phospho-DNA)-tyrosine intermediate
Superoxide dismutase copper/zinc binding
Viral late gene transcription factor 3 zinc ribbon
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
CobB/CobQ-like glutamine amidotransferase
Peptidase S9 prolyl oligopeptidase catalytic
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Phosphoribosylformylglycinamidine synthase linker
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Elongation factor G-binding protein N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Menaquinone biosynthesis protein MenD middle
Polysaccharide biosynthesis protein CapD-like
Large ribosomal subunit protein uL30-like ferredoxin-like fold
SUF system FeS cluster assembly SufBD N-terminal
Essential for prephenate dehydratase activity
Alpha-glycerophosphate oxidase C-terminal
Penicillin-binding protein transpeptidase
ATP synthase F1 complex delta/epsilon subunit N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Phosphomannose isomerase type I catalytic
Helix-hairpin-helix DNA-binding motif class 1
Polymerase/histidinol phosphatase N-terminal
Cytochrome oxidase subunit II transmembrane region profile
Involved in allosteric activation by GTP
Peptidase M1 membrane alanine aminopeptidase
Septum formation inhibitor MinC C-terminal
Alanyl-transfer RNA synthetases family profile
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-122)
Plays an important role in substrate specificity
Reversibly protonated during proton transport
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
May play a role in transmitting local conformational changes
DNA-directed DNA polymerase family A palm
TRAP C4-dicarboxylate transport system permease DctM subunit
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Large ribosomal subunit protein uL2 C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Cytochrome C biogenesis protein transmembrane
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Type I restriction modification DNA specificity
Serine aminopeptidase S33 domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
Gram-positive cocci surface proteins LPxTG
Gram-positive cocci surface proteins LPxTG domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate
Glucose-methanol-choline oxidoreductase N-terminal
Conserved virulence factor B-like winged helix
Translation elongation factor P/YeiP central
Prepilin type IV endopeptidase peptidase
Flagellar assembly protein FliH/Type III secretion system HrpE
Mannose-6-phosphate isomerase type II C-terminal
Interaction with polymerase core subunit RpoC
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Large ribosomal subunit protein uL6 alpha-beta
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Bacterial type II secretion system protein E
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Cytochrome b/b6 C-terminal region profile
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Ribosomal RNA adenine methylase transferase N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
General stress protein FMN-binding split barrel
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Exonuclease VII large subunit C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Heat-inducible transcription repressor HrcA C-terminal
Flagellar motor switch protein FliN-like C-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
RNA 2-O ribose methyltransferase substrate binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Bacterial transcription activator effector binding
Na+-translocating membrane potential-generating system MpsC
Na+/H+ antiporter MnhB subunit-related protein
Mandelate racemase/muconate lactonizing enzyme C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Glucosamine/galactosamine-6-phosphate isomerase
Small ribosomal subunit protein uS4 N-terminal
DNA polymerase III delta subunit C-terminal
Glycine cleavage T-protein C-terminal barrel
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Cation-transporting P-type ATPase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
YbaK/aminoacyl-tRNA synthetase-associated
Thiamin/hydroxymethyl pyrimidine-binding YkoF putative
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
DNA replication/recombination mediator RecO N-terminal
Polysaccharide biosynthesis protein C-terminal
Non-canonical purine NTP phosphatase/PRRC1
RNA polymerase sigma factor 70 region 4 type 2
Pyridoxamine 5'-phosphate oxidase putative
Ribose-phosphate pyrophosphokinase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Putative component of 'biosynthetic module'
Thiamin pyrophosphokinase thiamin-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Inosine/uridine-preferring nucleoside hydrolase
Thymidylate synthase/dCMP hydroxymethylase
S-adenosylmethionine-dependent methyltransferase
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Resolvase/invertase-type recombinase catalytic
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Schiff-base intermediate with acetaldehyde
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Transposase IS116/IS110/IS902 C-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Ionotropic glutamate receptor C-terminal
Schiff-base intermediate with dihydroxyacetone-P
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transcriptional regulator SgrR N-terminal HTH
Cell wall-active antibiotics response LiaF-like C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
DNA mismatch repair proteins mutS family
Heme-copper oxidase subunit III family profile
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Gly-cisPro motif, important for rejection of L-amino acids
Saccharopine dehydrogenase-like C-terminal
Excalibur calcium-binding domain-containing protein
Important for interaction with partner proteins
Molybdopterin cofactor biosynthesis C (MoaC)
Could play a key role in the communication between the regulatory and the substrate sites
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Sodium/calcium exchanger membrane region
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glucose-methanol-choline oxidoreductase C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Pseudouridine synthase I TruA alpha/beta
ABC transporter substrate-binding protein PnrA-like
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Putative aromatic acid exporter C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Phosphocysteine intermediate; for EIIB activity
Schiff-base intermediate with D-ribose 5-phosphate
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
NIF system FeS cluster assembly NifU C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glycoside hydrolase family 42 N-terminal
YbbR-like domain-containing protein YbbR
Large ribosomal subunit protein uL15/eL18
Cytochrome b/b6 N-terminal region profile
Bacterial bifunctional deaminase-reductase C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
tRNA pseudouridylate synthase B C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Chromosomal replication initiator DnaA C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Peptide methionine sulfoxide reductase MsrA
Flagellar hook-length control protein-like C-terminal
Tryptophan RNA-binding attenuator protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Important for autoinhibition of adenylyltransferase activity
RNA binding; important for wobble base 34 recognition
Phosphotransferase system enzyme I N-terminal
Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Bacterial Ig-like domain-containing protein