Erythromycin biosynthesis protein CIII-like central
Polyvinyl alcohol dehydrogenase (Cytochrome)
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Major facilitator superfamily (MFS) profile
Transposase IS116/IS110/IS902 C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Polymerase/histidinol phosphatase N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Pyridoxamine 5'-phosphate oxidase putative
Aminoacyl-transfer RNA synthetases class-II family profile
Peptidase M1 membrane alanine aminopeptidase
Microcin J25-processing protein McjB C-terminal
Removed in mature form; by autocatalysis
Solute-binding protein family 3/N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Translation elongation factor P/YeiP central
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Cellulase Ig-like domain-containing protein
Centromere-binding protein ParB C-terminal
Protein-glutamine gamma-glutamyltransferase TgpA N-terminal
NIF system FeS cluster assembly NifU N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Peptidase S9 prolyl oligopeptidase catalytic
Acetylserotonin O-methyltransferase dimerisation
Glycosyltransferase subfamily 4-like N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
CobB/CobQ-like glutamine amidotransferase
AB hydrolase-1 domain-containing protein
Sodium/calcium exchanger membrane region
Transition state stabilizer; via amide nitrogen
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Mycothiol-dependent maleylpyruvate isomerase metal-binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
4'-phosphopantetheinyl transferase N-terminal
Solute-binding protein family 5 domain-containing protein
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Cell envelope-related transcriptional attenuator
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Penicillin-binding protein transpeptidase
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Pyrimidine nucleoside phosphorylase C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Ribose-phosphate pyrophosphokinase N-terminal
Type IV methyl-directed restriction enzyme EcoKMcrB subunit DNA-binding
Glucose/Sorbosone dehydrogenase domain-containing protein
Alanyl-transfer RNA synthetases family profile
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
PsrA tetracyclin repressor-like C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Gram-positive cocci surface proteins LPxTG
Could be important to modulate the pK values of the two catalytic cysteine residues
Peptidase C39-like domain-containing protein
Nitrite/Sulfite reductase ferredoxin-like
Butirosin biosynthesis protein H N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Glutathionylspermidine synthase pre-ATP-grasp-like
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
6-phosphogluconate dehydrogenase NADP-binding
YbhB/YbcL family Raf kinase inhibitor-like protein
Putative regulatory protein FmdB Zinc ribbon
Histidine-specific methyltransferase SAM-dependent
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Gp5/Type VI secretion system Vgr protein OB-fold
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Sigma 54 modulation/S30EA ribosomal protein C-terminal
(-)-beta-caryophyllene synthase ((2E,6E)-farnesyl diphosphate cyclizing)
Plays a critical role for substrate recognition
Plays a critical role in the stabilization of intermediate cation
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Proton acceptor; for glutaminase activity
Membrane insertase YidC/Oxa/ALB C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Molybdenum cofactor biosynthesis protein F N-terminal
DNA-directed DNA polymerase family A palm
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Methylguanine DNA methyltransferase ribonuclease-like
Transcription regulator AsnC/Lrp ligand binding
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Pyruvate/ketoisovalerate oxidoreductase catalytic
Thiamine pyrophosphate enzyme TPP-binding
Large ribosomal subunit protein uL2 C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Inosine/uridine-preferring nucleoside hydrolase
Anthranilate synthase component I N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Methionyl-tRNA synthetase anticodon-binding
Tryptophan synthase beta chain-like PALP
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
RNA 2-O ribose methyltransferase substrate binding
Schiff-base intermediate with dihydroxyacetone-P
Pyridine nucleotide-disulphide oxidoreductase dimerisation
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Interaction with polymerase core subunit RpoC
SD-repeat containing protein B domain-containing protein
Fe/B12 periplasmic-binding domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glycosyl transferase family 3 N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Molybdopterin cofactor biosynthesis C (MoaC)
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Could play a key role in the communication between the regulatory and the substrate sites
Gfo/Idh/MocA-like oxidoreductase C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Periplasmic binding protein domain-containing protein
N,N-dimethylformamidase beta subunit-like C-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Anti-sigma-D factor RsdA sigma factor binding region
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Sporulation transcription regulator WhiA N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Schiff-base intermediate with substrate; via pyruvic acid
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Reversibly protonated during proton transport
Putative oxidoreductase/dehydrogenase Rossmann-like
SUF system FeS cluster assembly SufBD N-terminal
Prealbumin-like fold domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
Pyrroline-5-carboxylate reductase catalytic N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Extracellular repeat protein, HAF family
Styrene monooxygenase StyA putative substrate binding
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Helix-hairpin-helix DNA-binding motif class 1
Phosphotransferase system enzyme I N-terminal
Lantibiotic biosynthesis protein dehydration
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Plays an important role in substrate specificity
YbaK/aminoacyl-tRNA synthetase-associated
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Chitin-binding type-3 domain-containing protein
Prokaryotic-type class I peptide chain release factors
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Pyrroline-5-carboxylate reductase dimerisation
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Threonine/serine exporter-like N-terminal
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
PhoD-like phosphatase metallophosphatase
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
DNA replication/recombination mediator RecO N-terminal
Metallo-beta-lactamase domain-containing protein
DNA topoisomerase I catalytic core eukaryotic-type
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Small ribosomal subunit protein uS4 N-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Glycosyltransferase family 28 N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Ionotropic glutamate receptor C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
SGNH hydrolase-type esterase domain-containing protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Ricin B lectin domain-containing protein
HTH cro/C1-type domain-containing protein
Peptide methionine sulphoxide reductase MsrA
6-phosphogluconate dehydrogenase C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Capsule synthesis protein CapA domain-containing protein
CASPASE and TPR Repeat-Associated C-terminal
CASPASE and TPR Repeat-Associated N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Survival protein SurE-like phosphatase/nucleotidase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Glycine cleavage T-protein C-terminal barrel
DNA primase/polymerase bifunctional N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome b/b6 N-terminal region profile
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
S-adenosyl-L-homocysteine hydrolase NAD binding
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Solute-binding protein family 3/N-terminal domain-containing protein
Involved in ionization of N3 of dUMP, leading to its activation
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein
Beta-hexosaminidase bacterial type N-terminal
Phosphoribosylformylglycinamidine synthase linker
Amidohydrolase-related domain-containing protein
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Release factor glutamine methyltransferase N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Lactate utilization protein B C-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
Leucine-binding protein domain-containing protein
Glyoxalase/fosfomycin resistance/dioxygenase
ABC-type glycine betaine transport system substrate-binding
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Phosphomannose isomerase type I catalytic
Pyruvate phosphate dikinase AMP/ATP-binding
Gly-cisPro motif, important for rejection of L-amino acids
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Biopterin-dependent aromatic amino acid hydroxylase family profile
Gamma-glutamylcyclotransferase AIG2-like
AMP-activated protein kinase glycogen-binding
Positions MEP for the nucleophilic attack
Peptidoglycan binding-like domain-containing protein
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Tetracyclin repressor-like C-terminal group 31
Phosphocysteine intermediate; for EIIB activity
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Important for beta-aspartyl-AMP intermediate formation
Pyruvate dehydrogenase E1 component middle
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Large ribosomal subunit protein uL15/eL18
Chromosomal replication initiator DnaA C-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Alpha-glycerophosphate oxidase C-terminal
Exonuclease VII large subunit C-terminal