Major facilitator superfamily (MFS) profile
TonB-dependent receptor-like beta-barrel
Secretin/TonB short N-terminal domain-containing protein
RNA polymerase sigma factor 70 region 4 type 2
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Outer membrane protein beta-barrel domain-containing protein
ABC transporter substrate-binding protein
Signal transduction histidine kinase internal region
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
DNA topoisomerase I catalytic core eukaryotic-type
Tryptophan synthase beta chain-like PALP
Secretion system C-terminal sorting domain-containing protein
Outer membrane lipoprotein-sorting protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Polysaccharide biosynthesis protein C-terminal
Translation elongation factor EFTs/EF1B dimerisation
Phosphatidate phosphatase APP1 catalytic
Putative oxidoreductase/dehydrogenase Rossmann-like
Large ribosomal subunit protein uL15/eL18
Thiamin pyrophosphokinase thiamin-binding
Plays an important role in substrate specificity
Glutathionylspermidine synthase pre-ATP-grasp-like
Putative exodeoxyribonuclease 8 PDDEXK-like
Peptidase S8/S53 domain-containing protein
Thiopeptide-type bacteriocin biosynthesis
Anthranilate synthase component I N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Neutral/alkaline non-lysosomal ceramidase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Gliding motility-associated C-terminal domain-containing protein
Peptidase S9 prolyl oligopeptidase catalytic
Carboxypeptidase-like regulatory domain-containing protein
SusC/RagA family TonB-linked outer membrane protein
S-adenosylmethionine-dependent methyltransferase
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Polysaccharide chain length determinant N-terminal
Sphingolipid delta4-desaturase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Prolyl 3,4-dihydroxylase TPA1/OFD1 N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Survival protein SurE-like phosphatase/nucleotidase
Gliding motility-associated protein GldM C-terminal
Gliding motility-associated protein GldM N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glycosyl hydrolase family 13 catalytic domain-containing protein
Beta-lactamase class A catalytic domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
SusD/RagB family nutrient-binding outer membrane lipoprotein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Peptidase M1 membrane alanine aminopeptidase
Glycosyltransferase subfamily 4-like N-terminal
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Helix-hairpin-helix DNA-binding motif class 1
Phosphomannose isomerase type I catalytic
Inosine/uridine-preferring nucleoside hydrolase
Right handed beta helix domain-containing protein
Putative auto-transporter adhesin head GIN
Antitoxin Xre/MbcA/ParS-like toxin-binding
N6 adenine-specific DNA methyltransferase N-terminal
HicB-like antitoxin of toxin-antitoxin system
General stress protein FMN-binding split barrel
Positions MEP for the nucleophilic attack
UDP N-acetylglucosamine O-acyltransferase C-terminal
3-keto-disaccharide hydrolase domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Aromatic hydrocarbon degradation protein
Type IX secretion system protein PorV domain-containing protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Fibronectin type-III domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
RagB/SusD family nutrient uptake outer membrane protein
O-(5'-phospho-DNA)-tyrosine intermediate
Lipocalin-like domain-containing protein
TonB C-terminal domain-containing protein
Putative adhesin domain-containing protein
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Mandelate racemase/muconate lactonizing enzyme C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Saccharopine dehydrogenase-like C-terminal
tRNA pseudouridylate synthase B C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Alpha/beta hydrolase fold-5 domain-containing protein
Glycosyl hydrolases family 2 sugar binding
RlpA-like protein double-psi beta-barrel
Type IX secretion system membrane protein PorP/SprF
Sialate O-acetylesterase domain-containing protein
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Endoribonuclease L-PSP/chorismate mutase-like domain-containing protein
Penicillin-binding protein activator LpoB
Gfo/Idh/MocA-like oxidoreductase bacterial type C-terminal
Beta-hexosaminidase bacterial type N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Large ribosomal subunit protein uL30-like ferredoxin-like fold
FAD-dependent oxidoreductase 2 FAD binding
Cytochrome c-type biogenesis protein CcmF C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
ATP-grasp fold succinyl-CoA synthetase-type
Could be important to modulate the pK values of the two catalytic cysteine residues
Thymidylate synthase/dCMP hydroxymethylase
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Glycine cleavage T-protein C-terminal barrel
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
S-adenosyl-L-homocysteine hydrolase NAD binding
DNA mismatch repair proteins mutS family
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Cell division protein FtsQ/DivIB C-terminal
Methyltransferase type 11 domain-containing protein
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Large ribosomal subunit protein uL6 alpha-beta
Glyoxalase/fosfomycin resistance/dioxygenase
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
Aminoacyl-transfer RNA synthetases class-II family profile
TonB-dependent receptor-like beta-barrel domain-containing protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Peptide methionine sulphoxide reductase MsrA
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Translation elongation factor P/YeiP central
Intradiol ring-cleavage dioxygenases domain-containing protein
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
ATP-dependent DNA helicase RecG C-terminal
Glycine zipper domain-containing protein
Putative auto-transporter adhesin head GIN domain-containing protein
peptide-methionine (R)-S-oxide reductase
Type I restriction modification DNA specificity
Curlin associated repeat-containing protein
DNA replication/recombination mediator RecO N-terminal
Pseudouridine synthase I TruA alpha/beta
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Penicillin-binding protein transpeptidase
Glucose/Sorbosone dehydrogenase domain-containing protein
Beta-lactamase-inhibitor-like PepSY-like domain-containing protein
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Histidine kinase domain-containing protein
Sulfatase N-terminal domain-containing protein
Anaphase-promoting complex subunit 4 WD40 domain-containing protein
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
Phosphoadenosine phosphosulphate reductase
Caspase family p20 domain-containing protein
Beta-lactamase-related domain-containing protein
AB hydrolase-1 domain-containing protein
ABC-type uncharacterised transport system
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Chemotaxis methyl-accepting receptor HlyB-like 4HB MCP
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glycoside hydrolase family 5 domain-containing protein
Copper type II ascorbate-dependent monooxygenase C-terminal
Copper type II ascorbate-dependent monooxygenase C-terminal domain-containing protein
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Curli production assembly/transport component CsgF
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Dipeptidylpeptidase IV N-terminal domain-containing protein
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
RNA 2-O ribose methyltransferase substrate binding
Alpha glucuronidase N-terminal domain-containing protein
Ribosomal RNA adenine methylase transferase N-terminal
Polysaccharide biosynthesis protein CapD-like
Alpha-glycerophosphate oxidase C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Carboxypeptidase regulatory-like domain-containing protein
Prokaryotic-type class I peptide chain release factors
Gamma-glutamylcyclotransferase AIG2-like
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Homogentisate 1,2-dioxygenase N-terminal
Bacterial transcription activator effector binding
Water stress and hypersensitive response
Urease accessory protein UreH-like transmembrane
Peptide methionine sulfoxide reductase MsrA
Xylose isomerase-like TIM barrel domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
N-end rule aminoacyl transferase C-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Inner membrane protein YgaP-like transmembrane
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Cationic amino acid transporter C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Large ribosomal subunit protein uL2 C-terminal
Conserved virulence factor B-like winged helix
ATP synthase F1 complex delta/epsilon subunit N-terminal
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Calcium/calmodulin-dependent protein kinase II association-domain
Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein
5'-Nucleotidase C-terminal domain-containing protein
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Histidine kinase/HSP90-like ATPase domain-containing protein
Proton acceptor; for glutaminase activity
Bacterial surface antigen (D15) domain-containing protein
Type I restriction enzyme R protein N-terminal
Organic solvent tolerance-like N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
Type 1 periplasmic binding fold superfamily protein
Histidine-specific methyltransferase SAM-dependent
Small ribosomal subunit protein uS4 N-terminal
Putative beta-lactamase-inhibitor-like PepSY-like
Curli production assembly/transport component CsgE
NIF system FeS cluster assembly NifU C-terminal
TonB-dependent receptor plug domain-containing protein
Pectate lyase superfamily protein domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Cytochrome b561 bacterial/Ni-hydrogenase
Integral membrane protein YccS N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
N-sulphoglucosamine sulphohydrolase C-terminal
Glycosyl transferase family 3 N-terminal
Haem-binding uptake Tiki superfamily ChaN
Predicted pPIWI-associating nuclease group 2
Alpha-L-rhamnosidase six-hairpin glycosidase domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Heme-copper oxidase subunit III family profile
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Probable transposase IS891/IS1136/IS1341
Exonuclease VII large subunit C-terminal
Electron transfer via tryptophanyl radical
Pyrroline-5-carboxylate reductase dimerisation
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Alanyl-transfer RNA synthetases family profile
LamG-like jellyroll fold domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Gliding motility protein SprA N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Important for interaction with partner proteins
Moybdenum cofactor oxidoreductase dimerisation
Essential for prephenate dehydratase activity
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Choloylglycine hydrolase/NAAA C-terminal
Peptidase C1A papain C-terminal domain-containing protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Nucleophile; cysteine thiosulfonate intermediate
Gp5/Type VI secretion system Vgr protein OB-fold
Activator of Hsp90 ATPase homologue 1-like C-terminal
PBCV-specific basic adaptor domain-containing protein
Glycosyl-hydrolase 97 C-terminal oligomerisation
Chromosomal replication initiator DnaA C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Outer membrane lipoprotein BamD-like domain-containing protein
RNA binding; important for wobble base 34 recognition
6-phosphogluconate dehydrogenase C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
PhoD-like phosphatase metallophosphatase
Trigger factor ribosome-binding bacterial
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Membrane fusion protein biotin-lipoyl like
Peptidase M43 pregnancy-associated plasma-A
Cyclophilin-like domain-containing protein
Cation-transporting P-type ATPase N-terminal
Schiff-base intermediate with acetaldehyde
Peptidase M1 membrane alanine aminopeptidase domain-containing protein
Phosphogluconate dehydrogenase (decarboxylating) C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal