Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
FAD-dependent oxidoreductase 2 FAD binding
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Cellulose-binding Sde182 nucleoside hydrolase-like
Cellulose-binding Sde182 nucleoside hydrolase-like domain-containing protein
Aminoacyl-transfer RNA synthetases class-II family profile
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Large ribosomal subunit protein uL6 alpha-beta
Helix-hairpin-helix DNA-binding motif class 1
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
RNA polymerase sigma factor 70 region 4 type 2
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For 3-hydroxyacyl-CoA dehydrogenase activity
Exopolysaccharide production protein YjbE
Lipoprotein YgdI/YgdR-like SH3-like domain-containing protein
Important for substrate binding and specificity
Major facilitator superfamily (MFS) profile
Major facilitator superfamily associated
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Type VI secretion system IcmF C-terminal
Glycine zipper 2TM domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Glycosyl transferase family 8 C-terminal
Polymerase/histidinol phosphatase N-terminal
Phosphoadenosine phosphosulphate reductase
Could be important to modulate the pK values of the two catalytic cysteine residues
DNA replication/recombination mediator RecO N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Flagella basal body P-ring formation protein FlgA
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Involved in allosteric activation by GTP
Membrane fusion protein biotin-lipoyl like
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Outer-membrane lipoprotein carrier protein
Schiff-base intermediate with acetaldehyde
TonB-dependent receptor-like beta-barrel
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Organic solvent tolerance-like N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Outer membrane protein assembly factor BamD
Gamma-glutamylcyclotransferase AIG2-like
Important for interaction with partner proteins
Interaction with polymerase core subunit RpoC
O-(phosphoribosyl dephospho-coenzyme A)serine
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Outer membrane protein assembly factor BamB
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Chromosomal replication initiator protein DnaA
Membrane iron-sulfur containing protein FtrD-like
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Glycosyl transferase family 3 N-terminal
RNA binding; important for wobble base 34 recognition
Bacteriophage tail tape measure C-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Glycine cleavage T-protein C-terminal barrel
Prokaryotic-type class I peptide chain release factors
Tryptophan synthase beta chain-like PALP
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
4'-phosphopantetheinyl transferase N-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Phage conserved hypothetical protein C-terminal
Type III secretion system flagellar brake protein YcgR PilZN
Peptidase S9 prolyl oligopeptidase catalytic
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Disulphide bond isomerase DsbC/G N-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
RND efflux pump membrane fusion protein barrel-sandwich
TRAP C4-dicarboxylate transport system permease DctM subunit
Glutathionylspermidine synthase pre-ATP-grasp-like
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Important for autoinhibition of adenylyltransferase activity
Cation-transporting P-type ATPase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythronate-4-phosphate dehydrogenase dimerisation
DNA polymerase III delta subunit C-terminal
Phosphoethanolamine transferase N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Inosine/uridine-preferring nucleoside hydrolase
Anthranilate synthase component I N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Electron transfer via tryptophanyl radical
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
RNA 2-O ribose methyltransferase substrate binding
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
DNA polymerase III subunit delta C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Translation elongation factor P/YeiP central
Phosphocysteine intermediate; for EIIB activity
Flagellar assembly protein FliH/Type III secretion system HrpE
Release factor glutamine methyltransferase N-terminal
Penicillin-insensitive murein endopeptidase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Phosphatidic acid phosphatase type 2/haloperoxidase
Acyl-ester intermediate; for transpeptidase activity
Penicillin-binding protein transpeptidase
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
O-(5'-phospho-DNA)-tyrosine intermediate
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Mandelate racemase/muconate lactonizing enzyme C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Prepilin type IV endopeptidase peptidase
Resolvase/invertase-type recombinase catalytic
O-(3'-phospho-DNA)-tyrosine intermediate
Lysozyme inhibitor LprI N-terminal domain-containing protein
Interacts with tRNA; defines subfamily-specific binding signature
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glycosyltransferase subfamily 4-like N-terminal
Flagellar hook-length control protein-like C-terminal
Type VI secretion system-associated protein
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
YdgH/BhsA/McbA-like domain-containing protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Choloylglycine hydrolase/NAAA C-terminal
Outer-membrane lipoprotein Wza C-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Alpha-glycerophosphate oxidase C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Bacterial type II secretion system protein E
NIF system FeS cluster assembly NifU C-terminal
Alanyl-transfer RNA synthetases family profile
Calcium/calmodulin-dependent protein kinase II association-domain
Carbamoyl-phosphate synthase small subunit N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Outer membrane assembly lipoprotein YfiO
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Required for dimer formation and molybdate binding
Glycoside hydrolase family 13 N-terminal
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Large ribosomal subunit protein uL15/eL18
Pyruvate phosphate dikinase AMP/ATP-binding
Outer membrane lipoprotein carrier protein LolA
Ribosomal RNA adenine methylase transferase N-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Reversibly protonated during proton transport
UDP N-acetylglucosamine O-acyltransferase C-terminal
Essential for prephenate dehydratase activity
RNA methyltransferase SpoU/TrmH type C-terminal
Tellurite resistance methyltransferase TehB-like
Acetylserotonin O-methyltransferase dimerisation
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Bacteriophage T7 Gp4 DNA primase/helicase N-terminal
AB hydrolase-1 domain-containing protein
6-phosphogluconate dehydrogenase C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Cob(I)alamin adenosyltransferase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Outer membrane protein assembly factor BamA
Sodium/calcium exchanger membrane region
Phosphotransferase system enzyme I N-terminal
Terminase large subunit-like endonuclease
Pyrroline-5-carboxylate reductase catalytic N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Plays an important role in substrate specificity
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Pyrimidine nucleoside phosphorylase C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Pyrroline-5-carboxylate reductase dimerisation
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Peptide methionine sulphoxide reductase MsrA
Alpha-D-phosphohexomutase alpha/beta/alpha
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
NIF system FeS cluster assembly NifU N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
ABC-type glycine betaine transport system substrate-binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Integral membrane protein YccS N-terminal
Putative conjugal transfer nickase/helicase TraI C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
HicB-like antitoxin of toxin-antitoxin system
Fe/B12 periplasmic-binding domain-containing protein
Polysaccharide chain length determinant N-terminal
Superoxide dismutase copper/zinc binding
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Metallo-beta-lactamase domain-containing protein
Transcriptional regulator SgrR N-terminal HTH
Sugar fermentation stimulation protein C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Essential for degradation by Lon protease
Glycoprotein-polysaccharide metabolism protein
Molybdopterin cofactor biosynthesis C (MoaC)
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Cytochrome c-type biogenesis protein CcmF C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Bacterial CdiA-CT RNAse A domain-containing protein
Chromosomal replication initiator DnaA C-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Important for beta-aspartyl-AMP intermediate formation
Flagellar motor switch protein FliN N-terminal
Flagellar motor switch protein FliN-like C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Adenylyl/Guanylyl and SMODS C-terminal sensor
Thiol:disulfide interchange protein DsbD
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Large ribosomal subunit protein uL2 C-terminal
Type II secretion system protein GspG C-terminal
Regulator of nucleoside diphosphate kinase N-terminal
DNA-directed DNA polymerase family A palm
Heme-copper oxidase subunit III family profile
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Cysteine sulfenic acid (-SOH) intermediate
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Ion-translocating oxidoreductase complex subunit G
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Non-canonical purine NTP phosphatase/PRRC1
Outer membrane protein assembly factor BamE
CagE TrbE VirB component of type IV transporter system central
SUF system FeS cluster assembly SufBD N-terminal
Threonine/serine exporter-like N-terminal
Lipopolysaccharide export system protein LptA
YbaK/aminoacyl-tRNA synthetase-associated
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-98)
Formate-dependent nitrite reductase complex subunit
Glycosyl hydrolase-like 10 domain-containing protein
Interaction with tRNA. Important for base-flipping
Interaction with tRNA; Important for base-flipping
Pseudouridine synthase I TruA alpha/beta
NADH:ubiquinone oxidoreductase 30kDa subunit
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Small ribosomal subunit protein uS4 N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Lytic transglycosylase superhelical linker
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Appears to be important in orienting the phosphate for catalysis
Schiff-base intermediate with substrate; via pyruvic acid
Penicillin-binding protein activator LpoA
Two-component system QseEF-associated lipoprotein QseG
Beta-xylosidase C-terminal Concanavalin A-like
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Outer membrane protein assembly factor BamC
Gly-cisPro motif, important for rejection of L-amino acids
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Iron ABC transporter substrate-binding protein
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glycoside hydrolase family 42 N-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Pyruvate dehydrogenase E1 component middle
Mechanosensitive ion channel inner membrane
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Exonuclease VII large subunit C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Positions MEP for the nucleophilic attack
Ribose-phosphate pyrophosphokinase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Type II secretion system protein GspI C-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Large ribosomal subunit protein bL25 L25
BREX system Lon protease-like BrxL N-terminal
Copper-binding periplasmic metallochaperone CueP
Glycoside hydrolase family 31 N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Nucleoside-specific channel-forming protein Tsx
Protein-methionine-sulfoxide reductase catalytic subunit MsrP
Capsule biosynthesis GfcC-like C-terminal
Capsule biosynthesis GfcC-like N-terminal
Curli production assembly/transport component CsgG
High-affinity zinc uptake system protein ZnuA
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Methylguanine DNA methyltransferase ribonuclease-like
Arginine decarboxylase C-terminal helical
Membrane-bound lytic murein transglycosylase C
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Lipoprotein SmpA/OmlA domain-containing protein
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Prepilin peptidase dependent protein C-like C-terminal