P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein
Anaphase-promoting complex subunit 4-like WD40
Glycosyltransferase subfamily 4-like N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Membrane fusion protein biotin-lipoyl like
Large ribosomal subunit protein uL6 alpha-beta
Polysaccharide biosynthesis protein CapD-like
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Photosystem II manganese-stabilizing polypeptide
Exonuclease VII large subunit C-terminal
NIF system FeS cluster assembly NifU C-terminal
NIF system FeS cluster assembly NifU N-terminal
Alanyl-transfer RNA synthetases family profile
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Anthranilate synthase component I N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Glycoside hydrolase family 31 N-terminal
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Pyruvate phosphate dikinase AMP/ATP-binding
Shikimate dehydrogenase substrate binding N-terminal
Serine/threonine specific protein phosphatases
Glucosamine/galactosamine-6-phosphate isomerase
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Cytochrome C biogenesis protein transmembrane
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Major facilitator superfamily (MFS) profile
Glycosyl hydrolase family 98 putative carbohydrate-binding module domain-containing protein
RlpA-like protein double-psi beta-barrel
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Nitrite/Sulfite reductase ferredoxin-like
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Type I restriction modification DNA specificity
Aminoacyl-transfer RNA synthetases class-II family profile
DNA replication/recombination mediator RecO N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
TonB-dependent receptor-like beta-barrel
Abortive infection protein-like C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Penicillin-binding protein transpeptidase
Probable transposase IS891/IS1136/IS1341
Putative glycogen debranching enzyme N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Molybdopterin cofactor biosynthesis C (MoaC)
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Polymerase/histidinol phosphatase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Rubisco accumulation factor 1 C-terminal
Rubisco accumulation factor 1 alpha helical
Rubisco accumulation factor 1 helix turn helix
Transposon Tn7 transposition protein TnsD C-terminal
Histidine-specific methyltransferase SAM-dependent
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Glycosyl hydrolase-like 10 domain-containing protein
Opioid growth factor receptor (OGFr) conserved
Could play a key role in the communication between the regulatory and the substrate sites
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
Interaction with polymerase core subunit RpoC
Sodium/calcium exchanger membrane region
Cytochrome b561 bacterial/Ni-hydrogenase
SUF system FeS cluster assembly SufBD N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Ribulose bisphosphate carboxylase large subunit C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Glycosyltransferase 2-like prokaryotic type
Restriction endonuclease type I HsdR N-terminal
DNA primase/polymerase bifunctional N-terminal
Magnesium-protoporphyrin IX methyltransferase C-terminal
LPS export ABC transporter periplasmic protein LptC
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Phosphoribosylformylglycinamidine synthase linker
Outer membrane protein beta-barrel domain-containing protein
May play a role in transmitting local conformational changes
Heat-inducible transcription repressor HrcA C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Peptide methionine sulphoxide reductase MsrA
Involved in allosteric activation by GTP
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
Gly-cisPro motif, important for rejection of L-amino acids
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Organic solvent tolerance-like N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Prokaryotic-type class I peptide chain release factors
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Heme-copper oxidase subunit III family profile
Peptidoglycan recognition protein family
Cyanobacterial aminoacyl-tRNA synthetase CAAD
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Lysyl-tRNA synthetase N-terminal transmembrane region
Phosphatidylglycerol lysyltransferase C-terminal
Cation-transporting P-type ATPase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Magnesium chelatase subunit H N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
UDP N-acetylglucosamine O-acyltransferase C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
RNA polymerase sigma factor 70 region 4 type 2
Polysaccharide biosynthesis protein C-terminal
Tryptophan synthase beta chain-like PALP
Carbamoyl-phosphate synthase small subunit N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
6-phosphogluconate dehydrogenase C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
HicB-like antitoxin of toxin-antitoxin system
Essential for prephenate dehydratase activity
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Small ribosomal subunit protein uS4 N-terminal
Insecticide toxin TcdB middle/C-terminal
Insecticide toxin TcdB middle/N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Homocysteine biosynthesis enzyme sulfur-incorporation
S-adenosyl-L-homocysteine hydrolase NAD binding
Photosystem I reaction center subunit III
Phosphoadenosine phosphosulphate reductase
RNA-binding protein Tab2-like N-terminal
RNA-binding protein Tab2/Atab2 C-terminal
PhoD-like phosphatase metallophosphatase
Peptidase S9 prolyl oligopeptidase catalytic
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
CRISPR-associated protein Cas6 C-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Interacts with tRNA; defines subfamily-specific binding signature
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
RND efflux pump membrane fusion protein barrel-sandwich
Type I restriction enzyme R protein N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Prepilin type IV endopeptidase peptidase
Cell envelope-related transcriptional attenuator
Carboxypeptidase regulatory-like domain-containing protein
Thiamine pyrophosphate enzyme TPP-binding
Bacterial type II secretion system protein E
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Contractile injection system tube protein N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
EfeO-type cupredoxin-like domain-containing protein
DNA-directed DNA polymerase family A palm
Polysaccharide chain length determinant N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Chromosomal replication initiator DnaA C-terminal
Plastid lipid-associated protein/fibrillin conserved
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Lysozyme inhibitor LprI N-terminal domain-containing protein
Light-independent protochlorophyllide reductase subunit B-like C-terminal
Ribulose bisphosphate carboxylase small subunit
Photosystem II reaction center protein K
Helix-hairpin-helix DNA-binding motif class 1
Peptidase M1 membrane alanine aminopeptidase
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Reversibly protonated during proton transport
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
Electron transfer via tryptophanyl radical
CobB/CobQ-like glutamine amidotransferase
Inosine/uridine-preferring nucleoside hydrolase
Increases nucleophilicity of active site Cys
Glycosyl transferase family 3 N-terminal
Limiting CO2-inducible protein B/C beta carbonyic anhydrase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Glycine cleavage T-protein C-terminal barrel
ABC transporter substrate-binding protein PnrA-like
Sporulation stage II protein D amidase enhancer LytB N-terminal
Haem-binding uptake Tiki superfamily ChaN
Methionyl-tRNA synthetase anticodon-binding
N-sulphoglucosamine sulphohydrolase C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cob(I)alamin adenosyltransferase N-terminal
Resolvase/invertase-type recombinase catalytic
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Sodium symporter small subunit predicted
PEP-CTERM sorting domain-containing protein
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Aconitase A/isopropylmalate dehydratase small subunit swivel
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Tc toxin complex TcA C-terminal TcB-binding
Nitrogenase molybdenum-iron protein beta chain N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
ATP synthase F1 complex delta/epsilon subunit N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Protein O-mannosyl-transferase C-terminal four TM
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Sugar fermentation stimulation protein C-terminal
WGxxGxxG-CTERM domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Translation elongation factor P/YeiP central
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
DNA mismatch repair proteins mutS family
BREX system Lon protease-like BrxL N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Phosphodiester glycosidase domain-containing protein
Increases the nucleophilicity of the active site Cys
Proton acceptor; for glutaminase activity
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
NAD(P)H-quinone oxidoreductase subunit 2 N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Large ribosomal subunit protein uL15/eL18
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
RNA binding; important for wobble base 34 recognition
Probable endolytic peptidoglycan transglycosylase RlpA
CRISPR system ring nuclease SSO1393-like
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Ferredoxin thioredoxin reductase alpha chain
Cytochrome b/b6 C-terminal region profile
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Photosystem I PsaL reaction centre subunit XI
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Formylmethanofuran dehydrogenase subunit E
Mannose-6-phosphate isomerase type II C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Could be important to modulate the pK values of the two catalytic cysteine residues
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Photosystem II cytochrome b559 N-terminal
Calcium/calmodulin-dependent protein kinase II association-domain
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
C-type lysozyme inhibitor domain-containing protein
Predicted DNA-binding protein ribbon-helix-helix
Photosystem II cytochrome b559 alpha subunit lumenal region
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Positions MEP for the nucleophilic attack
Na+/H+ antiporter MnhB subunit-related protein
NADH-rubredoxin oxidoreductase C-terminal
Cytochrome b/b6 N-terminal region profile
Dinitrogenase iron-molybdenum cofactor biosynthesis
Schiff-base intermediate with acetaldehyde