Aminoacyl-transfer RNA synthetases class-II family profile
Tryptophan synthase beta chain-like PALP
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Arginine decarboxylase C-terminal helical
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Cation-transporting P-type ATPase N-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Glycosyltransferase 2-like prokaryotic type
peptide-methionine (R)-S-oxide reductase
Cytochrome b/b6 C-terminal region profile
Carbamoyl-phosphate synthase small subunit N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Saccharopine dehydrogenase-like C-terminal
Ferredoxin thioredoxin reductase alpha chain
Cytochrome b561 bacterial/Ni-hydrogenase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Membrane fusion protein biotin-lipoyl like
RND efflux pump membrane fusion protein barrel-sandwich
Glycosyl transferase family 3 N-terminal
CobB/CobQ-like glutamine amidotransferase
Resolvase/invertase-type recombinase catalytic
Pyrroline-5-carboxylate reductase catalytic N-terminal
Heme-copper oxidase subunit III family profile
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Glycosyltransferase subfamily 4-like N-terminal
Large ribosomal subunit protein uL15/eL18
Methionyl-tRNA synthetase anticodon-binding
Major facilitator superfamily (MFS) profile
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Pyrroline-5-carboxylate reductase dimerisation
ATP synthase F1 complex delta/epsilon subunit N-terminal
Peptidase M1 membrane alanine aminopeptidase
RNA polymerase sigma factor 70 region 4 type 2
Bacterial type II secretion system protein E
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Schiff-base intermediate with dihydroxyacetone-P
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Pseudouridine synthase I TruA alpha/beta
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Positions MEP for the nucleophilic attack
Pyridoxamine 5'-phosphate oxidase putative
Integrase lambda-type N-terminal DNA-binding
Anthranilate synthase component I N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Probable transposase IS891/IS1136/IS1341
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Acetylserotonin O-methyltransferase dimerisation
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Lantibiotic biosynthesis protein dehydration
N6 adenine-specific DNA methyltransferase N-terminal
Bacterial sensory transduction regulator
Photosystem I PsaL reaction centre subunit XI
HTH-type transcriptional regulator AraC-type N-terminal
Alanyl-transfer RNA synthetases family profile
Bacterial Glycosyl hydrolase family 3 C-terminal
Plays an important role in substrate specificity
Solute-binding protein family 3/N-terminal
Na+/H+ antiporter MnhB subunit-related protein
O-(5'-phospho-DNA)-tyrosine intermediate
Ribose-phosphate pyrophosphokinase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Putative glycogen debranching enzyme N-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Beta-lactamase hydrolase-like protein phosphatase-like
Ribulose bisphosphate carboxylase small subunit
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
General stress protein FMN-binding split barrel
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Cytochrome C biogenesis protein transmembrane
Glycosyltransferase family 28 N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Polysaccharide biosynthesis protein C-terminal
Type I restriction modification DNA specificity
Haem-binding uptake Tiki superfamily ChaN
PEP-CTERM exosortase interaction domain-containing protein
Na+-translocating membrane potential-generating system MpsC
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
TonB-dependent receptor-like beta-barrel
Schiff-base intermediate with substrate; via pyruvic acid
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Septum formation inhibitor MinC C-terminal
Light-independent protochlorophyllide reductase subunit B-like C-terminal
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
NIF system FeS cluster assembly NifU C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Penicillin-binding protein transpeptidase
Cob(I)alamin adenosyltransferase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Quercetin 2,3-dioxygenase C-terminal cupin
P pilus assembly protein, chaperone PapD
Ribosomal RNA adenine methylase transferase N-terminal
Polymerase/histidinol phosphatase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Peptidase S9 prolyl oligopeptidase catalytic
Outer membrane protein beta-barrel domain-containing protein
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component
Glyoxalase/fosfomycin resistance/dioxygenase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-100)
EfeO-type cupredoxin-like domain-containing protein
SUF system FeS cluster assembly SufBD N-terminal
Gamma-glutamylcyclotransferase AIG2-like
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Schiff-base intermediate with acetaldehyde
Glycoside hydrolase family 57 N-terminal
Polysaccharide biosynthesis protein CapD-like
Small ribosomal subunit protein uS4 N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Sodium/calcium exchanger membrane region
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Inverse autotransporter beta-domain domain-containing protein
Increases nucleophilicity of active site Cys
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
Rubisco accumulation factor 1 C-terminal
Rubisco accumulation factor 1 alpha helical
Rubisco accumulation factor 1 helix turn helix
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Mannose-6-phosphate isomerase type II C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Restriction system protein Mrr-like N-terminal
Type IV secretion system coupling protein TraD DNA-binding
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Outer membrane lipoprotein-sorting protein
Translation elongation factor P/YeiP central
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Electron transfer via tryptophanyl radical
DNA replication/recombination mediator RecO N-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Essential for prephenate dehydratase activity
NIF system FeS cluster assembly NifU N-terminal
Plastid lipid-associated protein/fibrillin conserved
NAD(P)H-quinone oxidoreductase subunit 2 N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
6-phosphogluconate dehydrogenase C-terminal
Histidine-specific methyltransferase SAM-dependent
Protein O-mannosyl-transferase C-terminal four TM
HicB-like antitoxin of toxin-antitoxin system
Antitoxin Xre/MbcA/ParS-like toxin-binding
Prokaryotic-type class I peptide chain release factors
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein
Glycosyl transferase family 28 C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Polypeptide-transport-associated ShlB-type
Important for beta-aspartyl-AMP intermediate formation
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Photosystem II cytochrome b559 N-terminal
Photosystem II cytochrome b559 alpha subunit lumenal region
1,4-alpha-glucan branching enzyme C-terminal
Large ribosomal subunit protein bL25 L25
Urease accessory protein UreE C-terminal
Photosystem I reaction center subunit III
Bacterial bifunctional deaminase-reductase C-terminal
Sulfatase-modifying factor enzyme domain-containing protein
Trypsin-like serine protease with C-terminal PDZ domain
Type I restriction enzyme R protein N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Curlin associated repeat-containing protein
Glutathionylspermidine synthase pre-ATP-grasp-like
Peptide methionine sulphoxide reductase MsrA
Cell envelope-related transcriptional attenuator
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Membrane insertase YidC/Oxa/ALB C-terminal
Cyanobacterial aminoacyl-tRNA synthetase CAAD
Large ribosomal subunit protein uL6 alpha-beta
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Cysteine sulfenic acid (-SOH) intermediate
Heat-inducible transcription repressor HrcA C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Reversibly protonated during proton transport
Homocysteine biosynthesis enzyme sulfur-incorporation
Impaired selectivity. Can conduct both K(+) and Na(+).
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Shikimate dehydrogenase substrate binding N-terminal
Spore coat protein U domain-containing protein
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Could be important to modulate the pK values of the two catalytic cysteine residues
Photosystem II reaction center protein K
Cytochrome b/b6 N-terminal region profile
glutathione gamma-glutamylcysteinyltransferase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Large ribosomal subunit protein uL2 C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Involved in allosteric activation by GTP
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Polyketide synthase phosphopantetheine-binding
Inward rectifier potassium channel C-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Mandelate racemase/muconate lactonizing enzyme C-terminal
DNA-directed DNA polymerase family A palm
Glucosamine/galactosamine-6-phosphate isomerase
UDP N-acetylglucosamine O-acyltransferase C-terminal
Calcium/calmodulin-dependent protein kinase II association-domain
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Interaction with polymerase core subunit RpoC
Magnesium chelatase subunit H N-terminal
Photosystem II manganese-stabilizing polypeptide
Anaphase-promoting complex subunit 4-like WD40
Type II restriction enzyme and methyltransferase RM.Eco57I-like
RNA-binding protein Tab2-like N-terminal
RNA-binding protein Tab2/Atab2 C-terminal
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
NAD(P) transhydrogenase alpha subunit C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS