Aconitase A/isopropylmalate dehydratase small subunit swivel
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Aminoacyl-transfer RNA synthetases class-II family profile
Large ribosomal subunit protein uL2 C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Cytochrome C biogenesis protein transmembrane
Tryptophan synthase beta chain-like PALP
Inosine/uridine-preferring nucleoside hydrolase
Involved in ionization of N3 of dUMP, leading to its activation
Glycine cleavage T-protein C-terminal barrel
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Penicillin-binding protein transpeptidase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Release factor glutamine methyltransferase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Peptidase S9 prolyl oligopeptidase catalytic
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Glycosyltransferase subfamily 4-like N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
O-(3'-phospho-DNA)-tyrosine intermediate
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
PhoD-like phosphatase metallophosphatase
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Prokaryotic-type class I peptide chain release factors
Important for substrate specificity; cannot use PPi as phosphoryl donor
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Polymerase/histidinol phosphatase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
RNA binding; important for wobble base 34 recognition
Plays an important role in substrate specificity
Major facilitator superfamily (MFS) profile
Positions MEP for the nucleophilic attack
Phosphomannose isomerase type I catalytic
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
RNA 2-O ribose methyltransferase substrate binding
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Translation elongation factor P/YeiP central
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Phosphatidic acid phosphatase type 2/haloperoxidase
Chromosomal replication initiator DnaA C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Inner membrane protein YgaP-like transmembrane
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Large ribosomal subunit protein uL15/eL18
Sporulation transcription regulator WhiA N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Putative oxidoreductase/dehydrogenase Rossmann-like
Schiff-base intermediate with D-ribose 5-phosphate
Essential for prephenate dehydratase activity
Resuscitation-promoting factor Rpf1 C-terminal
Resuscitation-promoting factor core lysozyme-like
Transglycosylase-like domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Small ribosomal subunit protein uS4 N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Carbamoyl-phosphate synthase small subunit N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Gly-cisPro motif, important for rejection of L-amino acids
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
NIF system FeS cluster assembly NifU N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Cytochrome bc1 complex cytochrome c subunit
Important for beta-aspartyl-AMP intermediate formation
BAAT/Acyl-CoA thioester hydrolase C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Anthranilate synthase component I N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Interaction with polymerase core subunit RpoC
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Acyl-CoA dehydrogenase/oxidase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
CobB/CobQ-like glutamine amidotransferase
Exonuclease VII large subunit C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Phosphotransferase system enzyme I N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Ribosome maturation factor RimP N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
RNA polymerase sigma factor 70 region 4 type 2
ATP synthase F1 complex delta/epsilon subunit N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Cytochrome b/b6 N-terminal region profile
Signal recognition particle receptor alpha subunit N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Could play a key role in the communication between the regulatory and the substrate sites
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Glycosyl transferase family 3 N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Alanyl-transfer RNA synthetases family profile
Glucosamine/galactosamine-6-phosphate isomerase
DNA replication/recombination mediator RecO N-terminal
4'-phosphopantetheinyl transferase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Heat-inducible transcription repressor HrcA C-terminal
ABC-type glycine betaine transport system substrate-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Reversibly protonated during proton transport
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Type I restriction modification DNA specificity
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Pseudouridine synthase I TruA alpha/beta
Large ribosomal subunit protein uL6 alpha-beta
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Peptidase M1 membrane alanine aminopeptidase
Ribose-phosphate pyrophosphokinase N-terminal
Phosphocysteine intermediate; for EIIB activity