Aminoacyl-transfer RNA synthetases class-II family profile
RNA binding; important for wobble base 34 recognition
N-end rule aminoacyl transferase C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Tryptophan synthase beta chain-like PALP
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Peptide methionine sulphoxide reductase MsrA
Proline utilization A proline dehydrogenase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Beta-lactamase-related domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
RNA polymerase sigma factor 70 region 4 type 2
Homogentisate 1,2-dioxygenase N-terminal
Bacterial virulence factor lipase N-terminal
Bacterial virulence factor lipase N-terminal domain-containing protein
Sodium/calcium exchanger membrane region
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Major facilitator superfamily (MFS) profile
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Haemolysin activator HlyB C-terminal domain-containing protein
Transglutaminase-like domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Carbamoyl-phosphate synthase small subunit N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
RNA 2-O ribose methyltransferase substrate binding
Bacterial type II secretion system protein E
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Type II secretion system protein GspC N-terminal
Signal transduction histidine kinase internal region
Type II secretion system protein GspI C-terminal
TonB-dependent receptor-like beta-barrel
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Fibronectin type-III domain-containing protein
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Cytochrome c-type biogenesis protein CcmF C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Polysaccharide chain length determinant N-terminal
Pseudouridine synthase I TruA alpha/beta
Penicillin-binding protein transpeptidase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Helix-hairpin-helix DNA-binding motif class 1
NADH:ubiquinone oxidoreductase-like 20kDa subunit
UDP N-acetylglucosamine O-acyltransferase C-terminal
Putative adhesin domain-containing protein
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-92)
Polysaccharide biosynthesis protein CapD-like
Anthranilate synthase component I N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
DNA polymerase III subunit delta C-terminal
Organic solvent tolerance-like N-terminal
RNA methyltransferase SpoU/TrmH type C-terminal
Electron transfer via tryptophanyl radical
Prepilin type IV endopeptidase peptidase
Lysidine-tRNA(Ile) synthetase C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Proton acceptor; for glutaminase activity
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptidase S9 prolyl oligopeptidase catalytic
Chalcone isomerase domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Ribose-phosphate pyrophosphokinase N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Translation elongation factor P/YeiP central
DNA replication/recombination mediator RecO N-terminal
Nitrite/Sulfite reductase ferredoxin-like
NIF system FeS cluster assembly NifU N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Heme-copper oxidase subunit III family profile
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Important for interaction with partner proteins
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Lysozyme inhibitor LprI N-terminal domain-containing protein
Outer-membrane lipoprotein carrier protein
Cation-transporting P-type ATPase N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Large ribosomal subunit protein uL2 C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Outer-membrane lipoprotein Wza C-terminal
Outer membrane protein assembly factor BamD
Important for beta-aspartyl-AMP intermediate formation
Glycine zipper 2TM domain-containing protein
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Cysteine sulfenic acid (-SOH) intermediate
Threonine/serine exporter-like N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Urease accessory protein UreH-like transmembrane
DNA-directed RNA polymerase RpoA/D/Rpb3-type
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Outer membrane protein assembly factor BamE
Pyruvate dehydrogenase E1 component middle
Interaction with polymerase core subunit RpoC
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
TIGR04219 family outer membrane beta-barrel protein
Adaptive response protein AidB N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
O-(3'-phospho-DNA)-tyrosine intermediate
Small ribosomal subunit protein uS4 N-terminal
Reversibly protonated during proton transport
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Polymerase/histidinol phosphatase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Outer membrane lipoprotein carrier protein LolA
Plays an important role in discriminating NADH against NADPH
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Endolytic peptidoglycan transglycosylase RlpA
DNA-directed DNA polymerase family A palm
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Thymidylate synthase/dCMP hydroxymethylase
Biopterin-dependent aromatic amino acid hydroxylase family profile
Putative beta-barrel assembly-enhancing protease
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Outer membrane protein beta-barrel domain-containing protein
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine
Survival protein SurE-like phosphatase/nucleotidase
Chromosomal replication initiator protein DnaA
Shikimate dehydrogenase substrate binding N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-105)
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Solute-binding protein family 3/N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Large ribosomal subunit protein uL15/eL18
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Arginine decarboxylase C-terminal helical
Histidine-specific methyltransferase SAM-dependent
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Outer membrane protein assembly factor BamA
Prokaryotic-type class I peptide chain release factors
Outer membrane lipoprotein-sorting protein
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Alginate export domain-containing protein
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Sugar fermentation stimulation protein C-terminal
Release factor glutamine methyltransferase N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Extracellular repeat protein, HAF family
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Peptidase M1 membrane alanine aminopeptidase
Intracellular proteinase inhibitor BsuPI
Intracellular proteinase inhibitor BsuPI domain-containing protein
Pyrimidine nucleoside phosphorylase C-terminal
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Saccharopine dehydrogenase-like C-terminal
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
TonB-dependent receptor-like beta-barrel domain-containing protein
Membrane insertase YidC/Oxa/ALB C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Required for zinc-mediated homotetramerization and catalytic activity
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Plays an important role in substrate specificity
Glycosyl transferase family 3 N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
NIF system FeS cluster assembly NifU C-terminal
Glycine cleavage T-protein C-terminal barrel
Positions MEP for the nucleophilic attack
Thiol:disulfide interchange protein DsbD