Acetylserotonin O-methyltransferase dimerisation
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Prepilin type IV endopeptidase peptidase
RND efflux pump membrane fusion protein barrel-sandwich
Phosphatidate phosphatase APP1 catalytic
RNA binding; important for wobble base 34 recognition
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Type II secretion system protein GspE N-terminal
Outer membrane beta-barrel domain-containing protein
Important for substrate specificity; cannot use PPi as phosphoryl donor
Tryptophan synthase beta chain-like PALP
Abnormal spindle-like microcephaly-associated protein ASH
Transmembrane protein 131-like N-terminal
Interaction with polymerase core subunit RpoC
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
TonB-dependent receptor-like beta-barrel
Quercetin 2,3-dioxygenase C-terminal cupin
Pyruvate phosphate dikinase AMP/ATP-binding
Prokaryotic-type class I peptide chain release factors
RNA polymerase sigma factor 70 region 4 type 2
Outer membrane protein beta-barrel domain-containing protein
Peptidase MA-like domain-containing protein
Glycosyltransferase subfamily 4-like N-terminal
General stress protein FMN-binding split barrel
Type II secretion system protein GspG C-terminal
Major facilitator superfamily (MFS) profile
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Right handed beta helix domain-containing protein
Contractile injection system tube protein N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Glucose/Sorbosone dehydrogenase domain-containing protein
Bacterial type II secretion system protein E
Cytochrome b561 domain-containing protein
Glycoside hydrolase family 31 N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
ABC-type uncharacterised transport system
DNA-directed DNA polymerase family A palm
6-phosphogluconate dehydrogenase NADP-binding
Carbamoyl-phosphate synthase small subunit N-terminal
Glycine cleavage T-protein C-terminal barrel
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Peptidase M1 membrane alanine aminopeptidase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Exonuclease VII large subunit C-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Heme-copper oxidase subunit III family profile
FAD-dependent oxidoreductase 2 FAD binding
AB hydrolase-1 domain-containing protein
ABC transporter substrate-binding protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Cytochrome oxidase subunit II copper A binding
Aspartate/homoserine dehydrogenase NAD-binding
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Peptidase C39-like domain-containing protein
Pyridoxamine 5'-phosphate oxidase putative
PilC beta-propeller domain-containing protein
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Amidohydrolase-related domain-containing protein
Terminase large subunit gp17-like C-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Predicted DNA-binding protein ribbon-helix-helix
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Peptidase M43 pregnancy-associated plasma-A
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Important for interaction with partner proteins
Penicillin-binding protein transpeptidase
Alpha-1,6-glucosidases pullulanase-type C-terminal
Glycoside hydrolase family 13 N-terminal
Reversibly protonated during proton transport
tRNA pseudouridylate synthase B C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Translation elongation factor P/YeiP central
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Small ribosomal subunit protein uS4 N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Polymerase/histidinol phosphatase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Formylmethanofuran dehydrogenase subunit E
Formylmethanofuran dehydrogenase subunit E domain-containing protein
Bacterial bifunctional deaminase-reductase C-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Peptidase S9 prolyl oligopeptidase catalytic
Glucodextranase-like C-terminal domain-containing protein
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Plays an important role in substrate specificity
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
PHA accumulation regulator DNA-binding N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NIF system FeS cluster assembly NifU N-terminal
Type I restriction enzyme R protein N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Mannose-6-phosphate isomerase type II C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Phosphatidic acid phosphatase type 2/haloperoxidase
Biopterin-dependent aromatic amino acid hydroxylase family profile
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Histidine-specific methyltransferase SAM-dependent
Na+/H+ antiporter MnhB subunit-related protein
Adventurous gliding motility protein CglF
Glycoside hydrolase family 2 catalytic domain-containing protein
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
2-oxoacid dehydrogenase acyltransferase catalytic
O-(3'-phospho-DNA)-tyrosine intermediate
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Peptidase M64 N-terminal domain-containing protein
Menaquinone biosynthesis protein MenD middle
Pyrroline-5-carboxylate reductase catalytic N-terminal
Lantibiotic biosynthesis protein dehydration
Peptide methionine sulphoxide reductase MsrA
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Outer membrane lipoprotein carrier protein LolA
Organic solvent tolerance-like N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
Could play a key role in the communication between the regulatory and the substrate sites
Signal transduction histidine kinase internal region
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Flagellar assembly protein FliH/Type III secretion system HrpE
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
PhoD-like phosphatase metallophosphatase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Polysaccharide chain length determinant N-terminal
3-beta hydroxysteroid dehydrogenase/isomerase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Adaptive response protein AidB N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Cation-transporting P-type ATPase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
Thiolase-like protein type 1 additional C-terminal
Insecticide toxin TcdB middle/N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Gamma-butyrobetaine hydroxylase-like N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Rhomboid family intramembrane serine protease
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Water stress and hypersensitive response
Water stress and hypersensitive response domain-containing protein
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Thiol:disulfide interchange protein DsbD N-terminal
Thiol:disulfide interchange protein DsbD N-terminal domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Type VI secretion system IcmF C-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Glycosyl transferase family 3 N-terminal
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Coenzyme Q-binding protein COQ10 START domain-containing protein
Neutral/alkaline non-lysosomal ceramidase N-terminal
DNA replication/recombination mediator RecO N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
S-adenosyl-L-homocysteine hydrolase NAD binding
Peptidase M61 catalytic domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Essential for prephenate dehydratase activity
Gly-cisPro motif, important for rejection of L-amino acids
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Helix-hairpin-helix DNA-binding motif class 1
ATP synthase F1 complex delta/epsilon subunit N-terminal
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
Pilus formation protein N-terminal domain-containing protein
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Tetrahydrodipicolinate-N-succinyltransferase chain A
Endonuclease/exonuclease/phosphatase domain-containing protein
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Membrane fusion protein biotin-lipoyl like
Probable endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Pseudouridine synthase I TruA alpha/beta
Putative Flp pilus-assembly TadG-like N-terminal
RNA 3'-terminal phosphate cyclase insert
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Cytochrome b561 bacterial/Ni-hydrogenase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Signal recognition particle SRP54 helical bundle
YVTN beta-propeller repeat-containing protein
RNA 2-O ribose methyltransferase substrate binding
Nuclear transport factor 2 family protein
Thymidylate synthase/dCMP hydroxymethylase
Chromosomal replication initiator DnaA C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Bacterial virulence factor lipase N-terminal
Integral membrane protein YccS N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Cytochrome c-552/4 domain-containing protein
Trigger factor ribosome-binding bacterial
NADH:flavin oxidoreductase/NADH oxidase N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Moves into active site upon enzyme activation, plays a role in electron transfer
Lysidine-tRNA(Ile) synthetase C-terminal
Haem-binding uptake Tiki superfamily ChaN
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Zinc-regulated TonB-dependent outer membrane receptor
Flagellar motor switch protein FliN-like C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
DNA mismatch repair proteins mutS family
Important for beta-aspartyl-AMP intermediate formation
Could be important to modulate the pK values of the two catalytic cysteine residues
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Superoxide dismutase copper/zinc binding
DNA topoisomerase I catalytic core eukaryotic-type
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Peptidase M17 leucyl aminopeptidase N-terminal
2,4-diaminopentanoate dehydrogenase C-terminal
SGNH hydrolase-type esterase domain-containing protein
Anaphase-promoting complex subunit 4-like WD40
Fibronectin type-III domain-containing protein
Phosphotransferase system enzyme I N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Putative peptidoglycan binding domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
Peptidase M10 metallopeptidase domain-containing protein
Putative regulatory protein FmdB Zinc ribbon
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Thiopeptide-type bacteriocin biosynthesis
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
EfeO-type cupredoxin-like domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Carbohydrate-binding domain-containing protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Schiff-base intermediate with dihydroxyacetone-P
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
S-adenosylmethionine-dependent methyltransferase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
N,N-dimethylformamidase beta subunit-like C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Type II secretion system protein GspC N-terminal
ABC transporter substrate-binding protein PnrA-like
Choloylglycine hydrolase/NAAA C-terminal
Neutral/alkaline non-lysosomal ceramidase C-terminal
RNA polymerase sigma factor 70 region 1.1
Chalcone isomerase domain-containing protein
Diiron non-heme beta-hydroxylase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
ATP-dependent DNA helicase RecG C-terminal
Adventurous gliding motility protein CglE
Glycoside hydrolase family 57 N-terminal
Alpha-glycerophosphate oxidase C-terminal
Styrene monooxygenase StyA putative substrate binding
Threonine/serine exporter-like N-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Adventurous gliding motility protein GltC
Alanyl-transfer RNA synthetases family profile
Dienelactone hydrolase domain-containing protein
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Proton acceptor; for glutaminase activity
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Bacterial surface antigen (D15) domain-containing protein
Prokaryotic glutathione synthetase ATP-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
6-phosphogluconate dehydrogenase C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Periplasmic copper-binding protein NosD beta helix
Periplasmic copper-binding protein NosD beta helix domain-containing protein
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein uL15/eL18
Polysaccharide biosynthesis protein C-terminal
Alpha-2-macroglobulin domain-containing protein
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal