NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Phosphocysteine intermediate; for EIIB activity
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
TonB-dependent receptor-like beta-barrel
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
DNA-directed DNA polymerase family A palm
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Plays an important role in substrate specificity
Fimbrial-type adhesion domain-containing protein
Type VI secretion system IcmF C-terminal
Electron transfer via tryptophanyl radical
Major facilitator superfamily (MFS) profile
Flagellar basal-body/hook protein C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Aminoacyl-transfer RNA synthetases class-II family profile
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
RND efflux pump membrane fusion protein barrel-sandwich
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Tryptophan synthase beta chain-like PALP
Membrane insertase YidC/Oxa/ALB C-terminal
Flagellar hook-length control protein-like C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Essential for prephenate dehydratase activity
Dihydrodipicolinate reductase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Penicillin-binding protein transpeptidase
Endonuclease/exonuclease/phosphatase domain-containing protein
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Inosine/uridine-preferring nucleoside hydrolase
Mannose-6-phosphate isomerase type II C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Important for interaction with partner proteins
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Transcriptional regulator SgrR N-terminal HTH
Thymidylate synthase/dCMP hydroxymethylase
Interaction with polymerase core subunit RpoC
Flagella basal body P-ring formation protein FlgA C-terminal
5-methylthioadenosine/S-adenosylhomocysteine deaminase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Outer-membrane lipoprotein carrier protein
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Flagellar basal body rod protein N-terminal
Membrane fusion protein biotin-lipoyl like
Outer membrane protein assembly factor BamB
DnaJ homologue subfamily C member 28 conserved
Schiff-base intermediate with acetaldehyde
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Solute-binding protein family 3/N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Bacteriophage tail tape measure C-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Cysteine sulfenic acid (-SOH) intermediate
YdgH/BhsA/McbA-like domain-containing protein
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Polymerase/histidinol phosphatase N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Essential for degradation by Lon protease
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Regulator of nucleoside diphosphate kinase N-terminal
Translation elongation factor P/YeiP central
Tellurite resistance methyltransferase TehB-like
Polysaccharide biosynthesis protein C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
4'-phosphopantetheinyl transferase N-terminal
Lytic transglycosylase superhelical linker
Positions MEP for the nucleophilic attack
CD-NTase-associated protein 12/Pycsar effector protein TIR
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Prokaryotic-type class I peptide chain release factors
Glycine cleavage T-protein C-terminal barrel
O-(5'-phospho-DNA)-tyrosine intermediate
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
RNA 2-O ribose methyltransferase substrate binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Exonuclease VII large subunit C-terminal
DNA polymerase III subunit delta C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Heme-copper oxidase subunit III family profile
Disulphide bond isomerase DsbC/G N-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Outer membrane protein assembly factor BamA
Mandelate racemase/muconate lactonizing enzyme C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Bacterial OB-fold domain-containing protein
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Alpha-D-phosphohexomutase alpha/beta/alpha
Carbamoyl-phosphate synthase small subunit N-terminal
Outer membrane protein assembly factor BamD
Glucosamine/galactosamine-6-phosphate isomerase
Cytochrome b561 bacterial/Ni-hydrogenase
Terminase large subunit-like endonuclease
Restriction endonuclease type II BpuJI N-terminal
Important for substrate binding and specificity
O-(phosphoribosyl dephospho-coenzyme A)serine
Ribosomal RNA adenine methylase transferase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Resolvase/invertase-type recombinase catalytic
RNA methyltransferase SpoU/TrmH type C-terminal
Phosphotransferase system enzyme I N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Erythronate-4-phosphate dehydrogenase dimerisation
YbaK/aminoacyl-tRNA synthetase-associated
Chromosomal replication initiator DnaA C-terminal
Involved in allosteric activation by GTP
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Meso-diaminopimelate D-dehydrogenase C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
NADH:ubiquinone oxidoreductase-like 20kDa subunit
UDP N-acetylglucosamine O-acyltransferase C-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Outer membrane protein assembly factor BamE
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Non-canonical purine NTP phosphatase/PRRC1
HicB-like antitoxin of toxin-antitoxin system
Aminoacyl-tRNA synthetase class I anticodon-binding
DNA replication/recombination mediator RecO N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Ionotropic glutamate receptor C-terminal
Attachment protein G3P N-terminal domain-containing protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glycosyl transferase family 8 C-terminal
Choloylglycine hydrolase/NAAA C-terminal
Interaction with tRNA; Important for base-flipping
Pseudouridine synthase I TruA alpha/beta
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
ABC transporter substrate-binding protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Sugar fermentation stimulation protein C-terminal
Glycosyl transferase family 3 N-terminal
Alanyl-transfer RNA synthetases family profile
Reversibly protonated during proton transport
DNA polymerase III delta subunit C-terminal
Proton acceptor; for glutaminase activity
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Moves into active site upon enzyme activation, plays a role in electron transfer
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Ribose-phosphate pyrophosphokinase N-terminal
ABC-type glycine betaine transport system substrate-binding
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glutathionylspermidine synthase pre-ATP-grasp-like
Pyruvate dehydrogenase E1 component middle
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Could be important to modulate the pK values of the two catalytic cysteine residues
Gamma-glutamylcyclotransferase AIG2-like
Phosphatidic acid phosphatase type 2/haloperoxidase
EfeO-type cupredoxin-like domain-containing protein
Arginine decarboxylase C-terminal helical
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Required for zinc-mediated homotetramerization and catalytic activity
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Interacts with tRNA; defines subfamily-specific binding signature
NADH:ubiquinone oxidoreductase 30kDa subunit
Tetrahydrodipicolinate-N-succinyltransferase chain A
Appears to be important in orienting the phosphate for catalysis
Hypersensitivity response secretion-like HrpJ
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Siderophore-interacting protein C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Major facilitator superfamily associated
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Penicillin-binding protein activator LpoB
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Type VI secretion system-associated protein TagO
NIF system FeS cluster assembly NifU C-terminal
Sel1 domain-containing protein repeat-containing protein
ABC-type transport auxiliary lipoprotein component
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Bacterial type II secretion system protein E
Dihydrodipicolinate reductase C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Metallo-beta-lactamase domain-containing protein
6-phosphogluconate dehydrogenase C-terminal
Chitin-binding type-4 domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Outer-membrane lipoprotein Wza C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Prepilin peptidase dependent protein C-like C-terminal
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Lysidine-tRNA(Ile) synthetase C-terminal
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Flagellar motor switch protein FliN-like C-terminal
DNA mismatch repair proteins mutS family
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal