Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA primase/polymerase bifunctional N-terminal
Methionyl-tRNA synthetase anticodon-binding
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Anthranilate synthase component I N-terminal
Major facilitator superfamily (MFS) profile
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Resuscitation-promoting factor core lysozyme-like
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Leucine-binding protein domain-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
RNA polymerase sigma factor 70 region 4 type 2
Pyridine nucleotide-disulphide oxidoreductase dimerisation
FAD-dependent oxidoreductase 2 FAD binding
Alpha galactosidase C-terminal beta sandwich
Alpha galactosidase C-terminal beta sandwich domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Phosphotransferase system enzyme I N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Chromosomal replication initiator DnaA C-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Aminoacyl-transfer RNA synthetases class-II family profile
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Bacterial bifunctional deaminase-reductase C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Conserved hypothetical protein CHP02679 N terminus
Gamma-glutamylcyclotransferase AIG2-like
Protein O-mannosyl-transferase C-terminal four TM
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Penicillin-binding protein transpeptidase
Transposase IS116/IS110/IS902 C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Alpha-glycerophosphate oxidase C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Quercetin 2,3-dioxygenase C-terminal cupin
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Cysteine sulfenic acid (-SOH) intermediate
Endoribonuclease L-PSP/chorismate mutase-like
Pyrimidine nucleoside phosphorylase C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Small ribosomal subunit protein uS4 N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Important for substrate specificity; cannot use PPi as phosphoryl donor
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Glucose-methanol-choline oxidoreductase C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Phosphomannose isomerase type I catalytic
Glycine zipper domain-containing protein
Threonine/serine exporter-like N-terminal
Bacterial type II secretion system protein E
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Cation-transporting P-type ATPase C-terminal
PhoD-like phosphatase metallophosphatase
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Essential for prephenate dehydratase activity
Important for beta-aspartyl-AMP intermediate formation
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Reversibly protonated during proton transport
RNA 2-O ribose methyltransferase substrate binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Glycosyltransferase subfamily 4-like N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Tryptophan synthase beta chain-like PALP
Exonuclease VII large subunit C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Shikimate dehydrogenase substrate binding N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
TetR transcriptional regulator Rv1219c-like C-terminal
Peptide methionine sulphoxide reductase MsrA
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Peptidase MA-like domain-containing protein
Cytochrome oxidase subunit II copper A binding
CobB/CobQ-like glutamine amidotransferase
O-(3'-phospho-DNA)-tyrosine intermediate
Ribosomally synthesized peptide with SipW-like signal peptide
Transcription regulator AsnC/Lrp ligand binding
Pseudouridine synthase I TruA alpha/beta
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Terminase large subunit-like endonuclease
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Prokaryotic-type class I peptide chain release factors
Proton acceptor; for glutaminase activity
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Restriction system protein Mrr-like N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Mandelate racemase/muconate lactonizing enzyme C-terminal
Glycosyl transferase family 3 N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Solute-binding protein family 3/N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Cytochrome b/b6 N-terminal region profile
Adaptive response protein AidB N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
SUF system FeS cluster assembly SufBD N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Heat-inducible transcription repressor HrcA C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Resolvase/invertase-type recombinase catalytic
DNA replication/recombination mediator RecO N-terminal
Meso-diaminopimelate D-dehydrogenase C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Aconitase A/isopropylmalate dehydratase small subunit swivel
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Putative oxidoreductase/dehydrogenase Rossmann-like
Poly-beta-hydroxybutyrate polymerase N-terminal
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
O-(5'-phospho-DNA)-tyrosine intermediate
Polymerase/histidinol phosphatase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Increases nucleophilicity of active site Cys
4'-phosphopantetheinyl transferase N-terminal
Alternate signal-mediated exported protein, RER_14450 family
Cytochrome C biogenesis protein transmembrane
Pyridoxamine 5'-phosphate oxidase putative
Positions MEP for the nucleophilic attack
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
NIF system FeS cluster assembly NifU N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Alanyl-transfer RNA synthetases family profile
L,D-transpeptidase catalytic domain-containing protein
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
N6 adenine-specific DNA methyltransferase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Large ribosomal subunit protein uL2 C-terminal
Removed in mature form; by autocatalysis
Large ribosomal subunit protein uL6 alpha-beta
Plays an important role in substrate specificity
Methylguanine DNA methyltransferase ribonuclease-like
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Na+/H+ antiporter MnhB subunit-related protein
Glucosamine/galactosamine-6-phosphate isomerase
Cell envelope-related transcriptional attenuator
Interaction with polymerase core subunit RpoC
Peptidase M1 membrane alanine aminopeptidase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Putative regulatory protein FmdB Zinc ribbon
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Prepilin type IV endopeptidase peptidase
Phosphoribosylformylglycinamidine synthase linker
Superoxide dismutase copper/zinc binding
Membrane insertase YidC/Oxa/ALB C-terminal
Schiff-base intermediate with acetaldehyde
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Pyruvate dehydrogenase E1 component middle
RNA binding; important for wobble base 34 recognition
Involved in ionization of N3 of dUMP, leading to its activation
Large ribosomal subunit protein uL15/eL18
Glycine cleavage T-protein C-terminal barrel
Could play a key role in the communication between the regulatory and the substrate sites
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Translation elongation factor P/YeiP central
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
N-acetyltransferase domain-containing protein
6-phosphogluconate dehydrogenase C-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA