TRAP C4-dicarboxylate transport system permease DctM subunit
Histidine phosphotransferase ChpT C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
NAD(P) transhydrogenase alpha subunit C-terminal
High-affinity zinc uptake system protein ZnuA
Glycosyl transferase family 3 N-terminal
Leucine-binding protein domain-containing protein
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Bacterial type II secretion system protein E
Cation-transporting P-type ATPase N-terminal
Alanyl-transfer RNA synthetases family profile
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Plasmid replication protein C C-terminal
Plasmid replication protein C N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Glycine zipper domain-containing protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
RND efflux pump membrane fusion protein barrel-sandwich
Proton acceptor; for glutaminase activity
YbaK/aminoacyl-tRNA synthetase-associated
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Interaction with polymerase core subunit RpoC
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Major facilitator superfamily (MFS) profile
Chromosomal replication initiator DnaA C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Ribose-phosphate pyrophosphokinase N-terminal
Penicillin-binding protein transpeptidase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
SsuA/THI5-like domain-containing protein
Phosphoadenosine phosphosulphate reductase
Metallo-beta-lactamase domain-containing protein
Involved in allosteric activation by GTP
Important for interaction with partner proteins
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Tripartite-type tricarboxylate transporter, receptor component TctC
Saccharopine dehydrogenase-like C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Invasion associated locus B family protein
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Resolvase/invertase-type recombinase catalytic
Cytochrome c oxidase subunit IV bacterial aa3 type
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Antitoxin Xre/MbcA/ParS-like toxin-binding
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Membrane fusion protein biotin-lipoyl like
Cobaltochelatase subunit CobS N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glycine cleavage T-protein C-terminal barrel
Tetrahydrodipicolinate-N-succinyltransferase chain A
Phenol hydroxylase C-terminal dimerisation
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Tryptophan synthase beta chain-like PALP
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
L,D-transpeptidase catalytic domain-containing protein
Transglycosylase SLT domain-containing protein
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Cytochrome C biogenesis protein transmembrane
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Beta-lactamase hydrolase-like protein phosphatase-like
Transcription regulator AsnC/Lrp ligand binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glucosamine/galactosamine-6-phosphate isomerase
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
CagE TrbE VirB component of type IV transporter system central
Cytochrome c-type biogenesis protein CcmF C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Glucose-methanol-choline oxidoreductase N-terminal
CDP-alcohol phosphatidyltransferase C-terminal
Iron(III) transport system substrate-binding protein
O-(3'-phospho-DNA)-tyrosine intermediate
Endoribonuclease L-PSP/chorismate mutase-like
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Large ribosomal subunit protein uL30-like ferredoxin-like fold
ABC-type glycine betaine transport system substrate-binding
Transposase IS116/IS110/IS902 C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Peptide methionine sulphoxide reductase MsrA
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Signal transduction histidine kinase HWE region
Could play a key role in the communication between the regulatory and the substrate sites
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Phosphoribosylformylglycinamidine synthase linker
O-(5'-phospho-DNA)-tyrosine intermediate
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Bacterial bifunctional deaminase-reductase C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
RNA 2-O ribose methyltransferase substrate binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Inner membrane protein YgaP-like transmembrane
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Prepilin type IV endopeptidase peptidase
Putative exodeoxyribonuclease 8 PDDEXK-like
N-end rule aminoacyl transferase C-terminal
Polysaccharide biosynthesis protein CapD-like
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Phosphatidic acid phosphatase type 2/haloperoxidase
Exonuclease VII large subunit C-terminal
DNA topoisomerase I catalytic core eukaryotic-type
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Tripartite tricarboxylate transporter substrate binding protein BugD
Ribulose bisphosphate carboxylase small subunit
Probable periplasmic serine endoprotease DegP-like
FAD-dependent oxidoreductase 2 FAD binding
Alpha-glycerophosphate oxidase C-terminal
RNA polymerase sigma factor 70 region 4 type 2
PHA accumulation regulator DNA-binding N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Superoxide dismutase copper/zinc binding
Electron transfer via tryptophanyl radical
Tricarboxylic transport membrane protein
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
K(+)-insensitive pyrophosphate-energized proton pump
Transcription elongation factor GreA/GreB N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Methionyl-tRNA synthetase anticodon-binding
UDP N-acetylglucosamine O-acyltransferase C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Ribosomal RNA adenine methylase transferase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Interacts with tRNA; defines subfamily-specific binding signature
Sodium/calcium exchanger membrane region
Thiamin pyrophosphokinase thiamin-binding
Transcription-repair-coupling factor C-terminal
Heme-copper oxidase subunit III family profile
UDP-glucose/GDP-mannose dehydrogenase C-terminal
DNA replication/recombination mediator RecO N-terminal
Sodium symporter small subunit predicted
Small ribosomal subunit protein uS4 N-terminal
HicB-like antitoxin of toxin-antitoxin system
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Reversibly protonated during proton transport
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
NADH-rubredoxin oxidoreductase C-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
SUF system FeS cluster assembly SufBD N-terminal
ABC transporter substrate-binding protein PnrA-like
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Proline utilization A proline dehydrogenase N-terminal
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Chromosomal replication initiator protein DnaA
Polysaccharide chain length determinant N-terminal
TonB-dependent receptor-like beta-barrel
Adaptive response protein AidB N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
PQQ-dependent catabolism-associated beta-propeller protein
Protein-methionine-sulfoxide reductase catalytic subunit MsrP
Prokaryotic-type class I peptide chain release factors
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Mannose-6-phosphate isomerase type II C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Cytochrome b561 bacterial/Ni-hydrogenase
Periplasmic binding protein domain-containing protein
Major facilitator superfamily associated
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
NADH:ubiquinone oxidoreductase 30kDa subunit
NIF system FeS cluster assembly NifU N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Carbamoyl-phosphate synthase small subunit N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Sugar fermentation stimulation protein C-terminal
Type I restriction modification DNA specificity
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glucose-methanol-choline oxidoreductase C-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Translation elongation factor P/YeiP central
6-phosphogluconate dehydrogenase C-terminal
Moybdenum cofactor oxidoreductase dimerisation
RNA binding; important for wobble base 34 recognition
Restriction system protein Mrr-like N-terminal
General stress protein FMN-binding split barrel
Pseudouridine synthase I TruA alpha/beta
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Polymerase/histidinol phosphatase N-terminal
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Alkaline proteinase inhibitor/ Outer membrane lipoprotein Omp19
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Essential for prephenate dehydratase activity
Required for zinc-mediated homotetramerization and catalytic activity
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Solute-binding protein family 5 domain-containing protein
Gamma-butyrobetaine hydroxylase-like N-terminal
Large ribosomal subunit protein uL2 C-terminal
Large ribosomal subunit protein uL15/eL18
Anthranilate synthase component I N-terminal
ABC transporter substrate-binding protein
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Na+/H+ antiporter MnhB subunit-related protein
Arsenite oxidase subunit AioA/Iodate reductase subunit IdrA 3Fe-4S cluster
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Survival protein SurE-like phosphatase/nucleotidase
Pyrimidine nucleoside phosphorylase C-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Beta-lactamase-related domain-containing protein
Release factor glutamine methyltransferase N-terminal