Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Gly-cisPro motif, important for rejection of L-amino acids
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Glycine cleavage T-protein C-terminal barrel
Inverse autotransporter beta-domain domain-containing protein
Major facilitator superfamily (MFS) profile
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Bacterial type II secretion system protein E
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Alpha-glycerophosphate oxidase C-terminal
Organic solvent tolerance-like N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Large ribosomal subunit protein uL2 C-terminal
D-galactarate/Altronate dehydratase C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
DNA-directed DNA polymerase family A palm
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
TonB C-terminal domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Molybdopterin cofactor biosynthesis C (MoaC)
Chromosomal replication initiator protein DnaA
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Tryptophan synthase beta chain-like PALP
Aminoacyl-transfer RNA synthetases class-II family profile
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Sodium/calcium exchanger membrane region
Outer membrane protein assembly factor BamE
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Positions MEP for the nucleophilic attack
Interacts with tRNA; defines subfamily-specific binding signature
Translation elongation factor P/YeiP central
Nitrite/Sulfite reductase ferredoxin-like
Release factor glutamine methyltransferase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Reversibly protonated during proton transport
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Glucose-methanol-choline oxidoreductase N-terminal
Chromosomal replication initiator DnaA C-terminal
6-phosphogluconate dehydrogenase C-terminal
Beta-hexosaminidase bacterial type N-terminal
RNA 2-O ribose methyltransferase substrate binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
DNA replication/recombination mediator RecO N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glutamate synthase alpha subunit C-terminal
Proton acceptor; for glutaminase activity
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Cell division protein FtsQ/DivIB C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
ABC transporter substrate-binding protein PnrA-like
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Ribose-phosphate pyrophosphokinase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glycine zipper 2TM domain-containing protein
Gamma-butyrobetaine hydroxylase-like N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Solute-binding protein family 3/N-terminal
TonB-dependent receptor-like beta-barrel
ABC-type glycine betaine transport system substrate-binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Ribosomal RNA adenine methylase transferase N-terminal
Polysaccharide biosynthesis protein CapD-like
Tetrahydrodipicolinate-N-succinyltransferase chain A
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Pyruvate phosphate dikinase AMP/ATP-binding
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Auto-transporter adhesin head GIN domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Plays an important role in substrate specificity
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Carbamoyl-phosphate synthase small subunit N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
AraC-type arabinose-binding/dimerisation
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Glycoside hydrolase family 42 N-terminal
Ribulose bisphosphate carboxylase small subunit
Pseudouridine synthase I TruA alpha/beta
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein uL15/eL18
ATP synthase F1 complex delta/epsilon subunit N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Polymerase/histidinol phosphatase N-terminal
Interaction with polymerase core subunit RpoC
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Polysaccharide chain length determinant N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA polymerase III subunit delta C-terminal
Penicillin-binding protein transpeptidase
NIF system FeS cluster assembly NifU N-terminal
Important for interaction with partner proteins
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glycosyl transferase family 3 N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Prepilin type IV endopeptidase peptidase
S-adenosyl-L-homocysteine hydrolase NAD binding
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
6-phosphogluconate dehydrogenase NADP-binding domain-containing protein
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Prokaryotic-type class I peptide chain release factors
Membrane insertase YidC/Oxa/ALB C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Electron transfer via tryptophanyl radical
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Heme-copper oxidase subunit III family profile
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Helix-hairpin-helix DNA-binding motif class 1
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
ABC transporter substrate-binding protein
Survival protein SurE-like phosphatase/nucleotidase
Outer membrane lipoprotein-sorting protein
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Saccharopine dehydrogenase-like C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Thymidylate synthase/dCMP hydroxymethylase
NIF system FeS cluster assembly NifU C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Calcium/calmodulin-dependent protein kinase II association-domain
Phosphoethanolamine transferase N-terminal
Small ribosomal subunit protein uS4 N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Large ribosomal subunit protein uL6 alpha-beta
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Important for substrate binding and specificity
Essential for prephenate dehydratase activity
Peptide methionine sulphoxide reductase MsrA
Acyl-CoA dehydrogenase C-terminal bacterial-type
Cytochrome c-type biogenesis protein CcmF C-terminal
Pyruvate dehydrogenase E1 component middle
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding