Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Tripartite tricarboxylate transporter substrate binding protein
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
RNA polymerase sigma factor 70 region 4 type 2
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycosyl transferase family 3 N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Outer membrane lipoprotein carrier protein LolA
Solute-binding protein family 3/N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glycosyltransferase subfamily 4-like N-terminal
TonB-dependent receptor-like beta-barrel
Cytochrome b561 bacterial/Ni-hydrogenase
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Major facilitator superfamily (MFS) profile
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Tryptophan synthase beta chain-like PALP
Toxin co-regulated pilus biosynthesis protein Q C-terminal
Toxin co-regulated pilus biosynthesis protein Q C-terminal domain-containing protein
Membrane fusion protein biotin-lipoyl like
Beta-lactamase hydrolase-like protein phosphatase-like
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Activator of Hsp90 ATPase homologue 1-like C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Aminoacyl-transfer RNA synthetases class-II family profile
Protocatechuate 3,4-dioxygenase beta subunit N-terminal
Flagellar motor switch protein FliN-like C-terminal
Cation-transporting P-type ATPase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
TRAP C4-dicarboxylate transport system permease DctM subunit
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
O-(3'-phospho-DNA)-tyrosine intermediate
YbaK/aminoacyl-tRNA synthetase-associated
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
PHA accumulation regulator DNA-binding N-terminal
Resolvase/invertase-type recombinase catalytic
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Essential for prephenate dehydratase activity
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
S-adenosyl-L-homocysteine hydrolase NAD binding
Anthranilate synthase component I N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Antitoxin Xre/MbcA/ParS-like toxin-binding
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Important for beta-aspartyl-AMP intermediate formation
Bacterial type II secretion system protein E
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Cytochrome oxidase subunit II copper A binding
Pyrimidine nucleoside phosphorylase C-terminal
4'-phosphopantetheinyl transferase N-terminal
Interacts with tRNA; defines subfamily-specific binding signature
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Inner membrane protein YgaP-like transmembrane
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Alpha-glycerophosphate oxidase C-terminal
Penicillin-binding protein transpeptidase
Restriction system protein Mrr-like N-terminal
Glycine cleavage T-protein C-terminal barrel
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Siroheme decarboxylase AsnC-like ligand binding
Large ribosomal subunit protein uL2 C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Sodium/calcium exchanger membrane region
Prokaryotic-type class I peptide chain release factors
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Proton acceptor; for glutaminase activity
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Saccharopine dehydrogenase-like C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Cytochrome oxidase subunit II transmembrane region profile
Release factor glutamine methyltransferase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Phosphoribosylformylglycinamidine synthase linker
Bacterial bifunctional deaminase-reductase C-terminal
Bacterial EndoU nuclease domain-containing protein
ABC-type glycine betaine transport system substrate-binding
Ribosomal RNA adenine methylase transferase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Protein-arginine deiminase (PAD) central
Agrobacterium tumefaciens protein Atu4866
Glycosyl transferase family 28 C-terminal
Outer membrane protein assembly factor BamD
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Chromosomal replication initiator protein DnaA
Phosphoadenosine phosphosulphate reductase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Signal recognition particle SRP54 helical bundle
Molybdopterin cofactor biosynthesis C (MoaC)
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Exonuclease VII large subunit C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Important for interaction with partner proteins
Aromatic amino acid beta-eliminating lyase/threonine aldolase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
ssDNA thymidine ADP-ribosyltransferase DarT
Interaction with polymerase core subunit RpoC
Pseudouridine synthase I TruA alpha/beta
Flagellar hook-length control protein-like C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
UDP N-acetylglucosamine O-acyltransferase C-terminal
NIF system FeS cluster assembly NifU N-terminal
Heme-copper oxidase subunit III family profile
Large ribosomal subunit protein uL15/eL18
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
CDP-alcohol phosphatidyltransferase C-terminal
Schiff-base intermediate with acetaldehyde
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
ABC transporter substrate-binding protein PnrA-like
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
PhoD-like phosphatase metallophosphatase
Plays an important role in substrate specificity
Polysaccharide biosynthesis protein CapD-like
Transcription regulator AsnC/Lrp ligand binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Sugar fermentation stimulation protein C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Peptidase S9 prolyl oligopeptidase catalytic
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
RNA binding; important for wobble base 34 recognition
Aconitase A/isopropylmalate dehydratase small subunit swivel
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
DNA mismatch repair proteins mutS family
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Cysteine sulfenic acid (-SOH) intermediate
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Solute-binding protein family 3/N-terminal domain-containing protein
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)
DNA replication/recombination mediator RecO N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Peptide methionine sulphoxide reductase MsrA
Guanylate kinase/L-type calcium channel beta subunit
ABC transporter substrate-binding protein
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Reversibly protonated during proton transport
Could be important to modulate the pK values of the two catalytic cysteine residues
Translation elongation factor P/YeiP central
N6 adenine-specific DNA methyltransferase N-terminal
Transcription factor NikR nickel binding C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Thioredoxin-like fold domain-containing protein
Major facilitator superfamily associated
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Phosphotransferase system enzyme I N-terminal
Sodium symporter small subunit predicted
DNA-directed DNA polymerase family A palm
Alanyl-transfer RNA synthetases family profile
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Cobaltochelatase subunit CobS N-terminal
tRNA pseudouridylate synthase B C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Acyltransferase MbtK/IucB-like conserved
Glucan biosynthesis periplasmic MdoG C-terminal
Organic solvent tolerance-like N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
Type I restriction modification DNA specificity
Survival protein SurE-like phosphatase/nucleotidase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Large ribosomal subunit protein bL9 C-terminal
Haem-binding uptake Tiki superfamily ChaN
Haem-binding uptake Tiki superfamily ChaN domain-containing protein
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Important for substrate specificity; cannot use PPi as phosphoryl donor
Methionyl-tRNA synthetase anticodon-binding
Electron transfer via tryptophanyl radical
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
Large ribosomal subunit protein uL6 alpha-beta
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Pyruvate phosphate dikinase AMP/ATP-binding
Gamma-butyrobetaine hydroxylase-like N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Required for zinc-mediated homotetramerization and catalytic activity
Carbamoyl-phosphate synthase small subunit N-terminal
Glycosyltransferase family 28 N-terminal
Abortive infection protein-like C-terminal
Inosine/uridine-preferring nucleoside hydrolase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack