Chromosomal replication initiator protein DnaA
Phosphatidic acid phosphatase type 2/haloperoxidase
Solute-binding protein family 3/N-terminal
Outer membrane protein assembly factor BamB
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
NADH:flavin oxidoreductase/NADH oxidase N-terminal
6-phosphogluconate dehydrogenase C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Peptidase S9 prolyl oligopeptidase catalytic
Phosphocysteine intermediate; for EIIB activity
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Organic solvent tolerance-like N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Tellurite resistance methyltransferase TehB-like
Polysaccharide chain length determinant N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Major facilitator superfamily (MFS) profile
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
O-(3'-phospho-DNA)-tyrosine intermediate
Restriction endonuclease type I HsdR N-terminal
Bacteriophage T7 Gp4 DNA primase/helicase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Transcriptional regulator AbiEi antitoxin N-terminal
Sodium/calcium exchanger membrane region
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
RNA 2-O ribose methyltransferase substrate binding
Prokaryotic-type class I peptide chain release factors
Large ribosomal subunit protein uL30-like ferredoxin-like fold
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Interaction with polymerase core subunit RpoC
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Molybdopterin cofactor biosynthesis C (MoaC)
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Inosine/uridine-preferring nucleoside hydrolase
Tryptophan synthase beta chain-like PALP
Glycosyl transferase family 3 N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Shikimate dehydrogenase substrate binding N-terminal
Outer membrane protein assembly factor BamA
Lipopolysaccharide export system protein LptC
Pyruvate dehydrogenase E1 component middle
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Ionotropic glutamate receptor C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Bacterial type II secretion system protein E
Terminase large subunit gp17-like C-terminal
4'-phosphopantetheinyl transferase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
UDP N-acetylglucosamine O-acyltransferase C-terminal
ABC transporter substrate-binding protein
Penicillin-binding protein transpeptidase
DNA mismatch repair proteins mutS family
Translation elongation factor P/YeiP central
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
TonB-dependent receptor-like beta-barrel
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Exonuclease VII large subunit C-terminal
ABC-type glycine betaine transport system substrate-binding
Acyl-CoA dehydrogenase/oxidase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Cysteine sulfenic acid (-SOH) intermediate
Cob(I)alamin adenosyltransferase N-terminal
RNA methyltransferase SpoU/TrmH type C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Carbamoyl-phosphate synthase small subunit N-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Cytochrome b561 bacterial/Ni-hydrogenase
Aspartate/homoserine dehydrogenase NAD-binding
NIF system FeS cluster assembly NifU C-terminal
Required for dimer formation and molybdate binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Gly-cisPro motif, important for rejection of L-amino acids
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Integral membrane protein YccS N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
PEP-CTERM sorting domain-containing protein
Membrane fusion protein biotin-lipoyl like
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
N6 adenine-specific DNA methyltransferase N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Non-canonical purine NTP phosphatase/PRRC1
Aminoacyl-transfer RNA synthetases class-II family profile
Type 2A encapsulin shell protein SrpI-like
Anthranilate synthase component I N-terminal
Type VI secretion system IcmF C-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Glycosyltransferase subfamily 4-like N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Menaquinone biosynthesis protein MenD middle
Glycoside hydrolase family 31 N-terminal
Plays an important role in substrate specificity
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Spore coat protein U domain-containing protein
NIF system FeS cluster assembly NifU N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Heme-copper oxidase subunit III family profile
Flagellar basal body rod protein N-terminal
Threonine/serine exporter-like N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Reversibly protonated during proton transport
Alpha-D-phosphohexomutase alpha/beta/alpha
DNA replication/recombination mediator RecO N-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Small ribosomal subunit protein uS4 N-terminal
Nitrogenase molybdenum-iron protein beta chain N-terminal
Flagellar motor switch protein FliN-like C-terminal
Appears to be important in orienting the phosphate for catalysis
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Flagellar basal-body/hook protein C-terminal
Polymerase/histidinol phosphatase N-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
O-(5'-phospho-DNA)-tyrosine intermediate
Penicillin-binding protein activator LpoA
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Cobalamin-independent methionine synthase MetE N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
DnaJ homologue subfamily C member 28 conserved
Electron transfer via tryptophanyl radical
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Quercetin 2,3-dioxygenase C-terminal cupin
Interacts with tRNA; defines subfamily-specific binding signature
Pyruvate phosphate dikinase AMP/ATP-binding
Glycoside hydrolase family 42 N-terminal domain-containing protein
Glutathionylspermidine synthase pre-ATP-grasp-like
Type I restriction modification DNA specificity
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Alpha-glycerophosphate oxidase C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Prepilin type IV endopeptidase peptidase
Positions MEP for the nucleophilic attack
Involved in allosteric activation by GTP
Nucleoside-specific channel-forming protein Tsx
Polypeptide-transport-associated ShlB-type
Gamma-glutamylcyclotransferase AIG2-like
YbaK/aminoacyl-tRNA synthetase-associated
Outer membrane protein assembly factor BamD
Aconitase A/isopropylmalate dehydratase small subunit swivel
Thymidylate synthase/dCMP hydroxymethylase
SUF system FeS cluster assembly SufBD N-terminal
Alanyl-transfer RNA synthetases family profile
DNA polymerase III subunit delta C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Gp5/Type VI secretion system Vgr protein OB-fold
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Nitrite/Sulfite reductase ferredoxin-like
Outer membrane protein assembly factor BamE
Essential for degradation by Lon protease
Transposase IS116/IS110/IS902 C-terminal
Arginine decarboxylase C-terminal helical
Important for beta-aspartyl-AMP intermediate formation
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Superoxide dismutase copper/zinc binding
Glycosyl transferase family 8 C-terminal
Outer-membrane lipoprotein Wza C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Flagellar motor switch protein FliN N-terminal
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Fe/B12 periplasmic-binding domain-containing protein
Putative exodeoxyribonuclease 8 PDDEXK-like
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
HicB-like antitoxin of toxin-antitoxin system
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Large ribosomal subunit protein bL25 L25
Tetrahydrodipicolinate-N-succinyltransferase chain A
Helix-hairpin-helix DNA-binding motif class 1
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Prepilin peptidase dependent protein C-like C-terminal
Important for interaction with partner proteins
Membrane iron-sulfur containing protein FtrD-like
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Hypersensitivity response secretion-like HrpJ
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
DNA-directed DNA polymerase family A palm
Large ribosomal subunit protein uL2 C-terminal
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Outer-membrane lipoprotein carrier protein
Lytic transglycosylase superhelical linker
Transcription factor NikR nickel binding C-terminal
Type III restriction enzyme C-terminal endonuclease
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Required for zinc-mediated homotetramerization and catalytic activity
RNA binding; important for wobble base 34 recognition
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Release factor glutamine methyltransferase N-terminal
Erythronate-4-phosphate dehydrogenase dimerisation
Involved in ionization of N3 of dUMP, leading to its activation
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Phosphotransferase system enzyme I N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Lipopolysaccharide export system protein LptA
Ribosomal RNA adenine methylase transferase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Disulphide bond isomerase DsbC/G N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-97)
Moves into active site upon enzyme activation, plays a role in electron transfer
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Aldehyde ferredoxin oxidoreductase N-terminal
Phosphoethanolamine transferase N-terminal
Important for substrate binding and specificity
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Transcriptional regulator SgrR N-terminal HTH
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Essential for prephenate dehydratase activity
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Membrane-bound lytic murein transglycosylase C
Putative conjugal transfer nickase/helicase TraI C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Ion-translocating oxidoreductase complex subunit G
Mechanosensitive ion channel inner membrane
Glycine cleavage T-protein C-terminal barrel
Proline utilization A proline dehydrogenase N-terminal
Sugar fermentation stimulation protein C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Flagellar hook-length control protein-like C-terminal
Thiol:disulfide interchange protein DsbD
High-affinity zinc uptake system protein ZnuA
Periplasmic binding protein domain-containing protein
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Major facilitator superfamily associated
ABC-type transport auxiliary lipoprotein component
DNA polymerase III delta subunit C-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Large ribosomal subunit protein uL15/eL18