Aminoacyl-transfer RNA synthetases class-II family profile
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Solute-binding protein family 5 domain-containing protein
Inosine/uridine-preferring nucleoside hydrolase
NIF system FeS cluster assembly NifU C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Gram-positive cocci surface proteins LPxTG domain-containing protein
ABC-type glycine betaine transport system substrate-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Pyridine nucleotide-disulphide oxidoreductase dimerisation
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Major facilitator superfamily (MFS) profile
ABC transporter substrate-binding protein
Glucosamine/galactosamine-6-phosphate isomerase
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Phosphocysteine intermediate; for EIIB activity
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Cytochrome C biogenesis protein transmembrane
Release factor glutamine methyltransferase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
RNA polymerase sigma factor 70 region 4 type 2
Transposase IS116/IS110/IS902 C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Shikimate dehydrogenase substrate binding N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Alpha-1,6-glucosidases pullulanase-type C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Signal recognition particle SRP54 helical bundle
Phosphoribosylformylglycinamidine synthase linker
Pyruvate dehydrogenase E1 component middle
Molybdopterin cofactor biosynthesis C (MoaC)
Peptidase M1 membrane alanine aminopeptidase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
CobB/CobQ-like glutamine amidotransferase
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
ABC transporter substrate-binding protein PnrA-like
Mandelate racemase/muconate lactonizing enzyme C-terminal
Schiff-base intermediate with dihydroxyacetone-P
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Pyrimidine nucleoside phosphorylase C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
ABC-2 type transporter transmembrane domain-containing protein
Alpha-L-rhamnosidase six-hairpin glycosidase
Nitrite/Sulfite reductase ferredoxin-like
Protein O-mannosyl-transferase C-terminal four TM
Anthranilate synthase component I N-terminal
Peptidoglycan recognition protein family
Phosphomannose isomerase type I catalytic
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Gly-cisPro motif, important for rejection of L-amino acids
Reversibly protonated during proton transport
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Type I restriction modification DNA specificity
Polymerase/histidinol phosphatase N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Small ribosomal subunit protein uS4 N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
RNA 2-O ribose methyltransferase substrate binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Cell envelope-related transcriptional attenuator
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Septum formation-related domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptide methionine sulphoxide reductase MsrA
Schiff-base intermediate with acetaldehyde
Could play a key role in the communication between the regulatory and the substrate sites
UDP-glucose/GDP-mannose dehydrogenase C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Glycine cleavage T-protein C-terminal barrel
Tryptophan synthase beta chain-like PALP
Trigger factor ribosome-binding bacterial
Essential for prephenate dehydratase activity
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Translation elongation factor P/YeiP central
Important for substrate specificity; cannot use PPi as phosphoryl donor
Bacterial type II secretion system protein E
Gram-positive cocci surface proteins LPxTG
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
General stress protein FMN-binding split barrel
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Cysteine sulfenic acid (-SOH) intermediate
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
tRNA pseudouridylate synthase B C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
O-(3'-phospho-DNA)-tyrosine intermediate
Prokaryotic-type class I peptide chain release factors
Interaction with polymerase core subunit RpoC
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Phosphatidate phosphatase APP1 catalytic
Transposase IS204/IS1001/IS1096/IS1165 DDE
Exonuclease VII large subunit C-terminal
Thiamin/hydroxymethyl pyrimidine-binding YkoF putative
ATP-dependent DNA helicase RecG C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Solute-binding protein family 3/N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Schiff-base intermediate with substrate; via pyruvic acid
Large ribosomal subunit protein uL6 alpha-beta
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
6-phosphogluconate dehydrogenase C-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Pyrophosphate--fructose 6-phosphate 1-phosphotransferase
Thymidylate synthase/dCMP hydroxymethylase
Large ribosomal subunit protein uL15/eL18
SUF system FeS cluster assembly SufBD N-terminal
Phosphotransferase system enzyme I N-terminal
Prepilin type IV endopeptidase peptidase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Ionotropic glutamate receptor C-terminal
DNA replication/recombination mediator RecO N-terminal
Plays an important role in substrate specificity
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Beta-lactamase-related domain-containing protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Chromosomal replication initiator DnaA C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Gfo/Idh/MocA-like oxidoreductase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
3-beta hydroxysteroid dehydrogenase/isomerase
Alanyl-transfer RNA synthetases family profile
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
NIF system FeS cluster assembly NifU N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Penicillin-binding protein transpeptidase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Sporulation transcription regulator WhiA N-terminal
Phosphoadenosine phosphosulphate reductase
Electron transfer flavoprotein alpha subunit C-terminal
Lantibiotic biosynthesis protein dehydration
Resolvase/invertase-type recombinase catalytic
Glycosyl transferase family 3 N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Glycerophosphoryl diester phosphodiesterase membrane
DNA-directed DNA polymerase family A palm
Nucleophile; cysteine thiosulfonate intermediate
Proton acceptor; for glutaminase activity
Fe/B12 periplasmic-binding domain-containing protein