Could play a key role in the communication between the regulatory and the substrate sites
Glycoside hydrolase family 57 N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Translation elongation factor P/YeiP central
Solute-binding protein family 3/N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Disulphide bond isomerase DsbC/G N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Release factor glutamine methyltransferase N-terminal
RlpA-like protein double-psi beta-barrel
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
RND efflux pump membrane fusion protein barrel-sandwich
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Nucleoside-binding outer membrane protein
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Sodium/calcium exchanger membrane region
Inner membrane protein YgaP-like transmembrane
Cysteine sulfenic acid (-SOH) intermediate
Glucosamine/galactosamine-6-phosphate isomerase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Type IV secretion system coupling protein TraD DNA-binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Interaction with polymerase core subunit RpoC
Tryptophan synthase beta chain-like PALP
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
TonB-dependent receptor-like beta-barrel
Phosphoadenosine phosphosulphate reductase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Methanol dehydrogenase [cytochrome c] subunit 2
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
O-(5'-phospho-DNA)-tyrosine intermediate
Flagellar motor switch protein FliN-like C-terminal
Transglycosylase SLT domain-containing protein
Glycosyltransferase subfamily 4-like N-terminal
L,D-transpeptidase catalytic domain-containing protein
Phosphatidic acid phosphatase type 2/haloperoxidase
Glutathionylspermidine synthase pre-ATP-grasp-like
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Mechanosensitive ion channel inner membrane
Ribosomal RNA adenine methylase transferase N-terminal
HicB-like antitoxin of toxin-antitoxin system
1,4-alpha-glucan branching enzyme C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
3-beta hydroxysteroid dehydrogenase/isomerase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Aconitase A/isopropylmalate dehydratase small subunit swivel
6-hydroxymethylpterin diphosphokinase MptE-like
Alpha-carbonic anhydrase domain-containing protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Major facilitator superfamily (MFS) profile
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Major facilitator superfamily associated
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
O-(3'-phospho-DNA)-tyrosine intermediate
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glycosyl transferase family 3 N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Transposase IS116/IS110/IS902 C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
RNA binding; important for wobble base 34 recognition
TRAP C4-dicarboxylate transport system permease DctM subunit
RNA 2-O ribose methyltransferase substrate binding
Leucine-binding protein domain-containing protein
Pseudouridine synthase I TruA alpha/beta
Bacteriophage tail tape measure N-terminal
DNA mismatch repair proteins mutS family
Lytic transglycosylase superhelical linker
Antitoxin Xre/MbcA/ParS-like toxin-binding
Cytochrome b561 bacterial/Ni-hydrogenase
Exosortase system-associated protein, TIGR04073 family
Type I restriction modification DNA specificity
Type III secretion system flagellar brake protein YcgR PilZN
Outer membrane protein assembly factor BamB
Alginate export domain-containing protein
Arginine decarboxylase C-terminal helical
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Type II secretion system protein GspG C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Gly-cisPro motif, important for rejection of L-amino acids
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
L-2,4-diaminobutyric acid acetyltransferase
Penicillin-binding protein transpeptidase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
N-end rule aminoacyl transferase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
ATP-grasp fold succinyl-CoA synthetase-type
ATP synthase F1 complex delta/epsilon subunit N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Prepilin type IV endopeptidase peptidase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Aldehyde ferredoxin oxidoreductase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
May play a role in metal incorporation in vivo
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Pyrophosphate--fructose 6-phosphate 1-phosphotransferase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Pyruvate phosphate dikinase AMP/ATP-binding
N6 adenine-specific DNA methyltransferase N-terminal
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Outer-membrane lipoprotein carrier protein
Thymidylate synthase/dCMP hydroxymethylase
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Bacterial type II secretion system protein E
Important for substrate binding and specificity
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Polymerase/histidinol phosphatase N-terminal
ABC-type uncharacterised transport system
TonB system biopolymer transport component
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Gamma-butyrobetaine hydroxylase-like N-terminal
Outer membrane protein beta-barrel domain-containing protein
DNA-directed DNA polymerase family A palm
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Plays an important role in substrate specificity
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Thiamine pyrophosphate enzyme TPP-binding
Flagella basal body P-ring formation protein FlgA
Membrane fusion protein biotin-lipoyl like
Contractile injection system tube protein N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Urease accessory protein UreH-like transmembrane
Lipocalin-like domain-containing protein
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
YbaK/aminoacyl-tRNA synthetase-associated
Pyridoxamine 5'-phosphate oxidase putative
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NIF system FeS cluster assembly NifU N-terminal
Glycine-zipper-containing OmpA-like membrane
Glycine-zipper-containing OmpA-like membrane domain-containing protein
Heme-copper oxidase subunit III family profile
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
RNA polymerase sigma factor 70 region 4 type 2
Proton acceptor; for glutaminase activity
Chromosomal replication initiator DnaA C-terminal
Restriction endonuclease type I HsdR N-terminal
Protein-L-isoaspartate O-methyltransferase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Resolvase/invertase-type recombinase catalytic
Dinitrogenase iron-molybdenum cofactor biosynthesis
PEP-CTERM protein-sorting domain-containing protein
Large ribosomal subunit protein uL6 alpha-beta
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Pyrimidine nucleoside phosphorylase C-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Putative regulatory protein FmdB Zinc ribbon
Type I restriction enzyme HindI endonuclease subunit-like C-terminal
Polysaccharide biosynthesis protein C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Helix-hairpin-helix DNA-binding motif class 1
Polysaccharide biosynthesis protein CapD-like
Putative auto-transporter adhesin head GIN
Outer membrane lipoprotein carrier protein LolA
Important for interaction with partner proteins
Histidine-specific methyltransferase SAM-dependent
Large ribosomal subunit protein uL2 C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Glycine zipper domain-containing protein
Electron transfer via tryptophanyl radical
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Reversibly protonated during proton transport
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Peptide methionine sulphoxide reductase MsrA
Small ribosomal subunit protein uS4 N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Positions MEP for the nucleophilic attack
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
Essential for prephenate dehydratase activity
UDP N-acetylglucosamine O-acyltransferase C-terminal
Flagellar hook-length control protein-like C-terminal
Type II and III secretion system protein
Gamma-glutamylcyclotransferase AIG2-like
Bacterial bifunctional deaminase-reductase C-terminal
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Prokaryotic-type class I peptide chain release factors
Molybdopterin cofactor biosynthesis C (MoaC)
Carbamoyl-phosphate synthase small subunit N-terminal
Methylene-tetrahydromethanopterin dehydrogenase N-terminal
Anthranilate synthase component I N-terminal
S-adenosylmethionine-dependent methyltransferase
Glutamate synthase alpha subunit C-terminal
DNA replication/recombination mediator RecO N-terminal
Chromosomal replication initiator protein DnaA
AsmA-like C-terminal domain-containing protein
Important for autoinhibition of adenylyltransferase activity
Shikimate dehydrogenase substrate binding N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Lipoprotein SmpA/OmlA domain-containing protein
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
Nucleophile; cysteine thiosulfonate intermediate
6-phosphogluconate dehydrogenase C-terminal
Large ribosomal subunit protein uL15/eL18
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
S-adenosyl-L-homocysteine hydrolase NAD binding
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Thiol:disulfide interchange protein DsbD
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
DNA polymerase III delta subunit C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
NADH-rubredoxin oxidoreductase C-terminal
Stress-response A/B barrel domain-containing protein
SUF system FeS cluster assembly SufBD N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Survival protein SurE-like phosphatase/nucleotidase
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Cation-transporting P-type ATPase N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
DNA polymerase III subunit delta C-terminal
Acyl-CoA dehydrogenase C-terminal bacterial-type
Important for beta-aspartyl-AMP intermediate formation
Polypeptide-transport-associated ShlB-type
CRISPR-associated protein Cas6 C-terminal
ABC transporter substrate-binding protein
Glycine zipper 2TM domain-containing protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
PQQ-dependent catabolism-associated beta-propeller protein
NADH:flavin oxidoreductase/NADH oxidase N-terminal
ATPsynthase alpha/beta subunit N-terminal extension
Type VI secretion system IcmF C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Exonuclease VII large subunit C-terminal
Type III restriction enzyme C-terminal endonuclease
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Loss of catalytic activity; when associated with A-352.
Loss of catalytic activity; when associated with A-359.
Loss of catalytic activity; when associated with A-360.
Loss of catalytic activity; when associated with A-363.
Loss of catalytic activity; when associated with A-406.
Loss of catalytic activity; when associated with A-407.
Loss of catalytic activity; when associated with A-414.
Loss of catalytic activity; when associated with F-241.
Pyruvate dehydrogenase E1 component middle
Mannose-6-phosphate isomerase type II C-terminal