Type I restriction modification DNA specificity
RND efflux pump membrane fusion protein barrel-sandwich
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Aromatic amino acid beta-eliminating lyase/threonine aldolase
TonB-dependent receptor-like beta-barrel
Pseudouridine synthase I TruA alpha/beta
PEP-CTERM protein-sorting domain-containing protein
Toxin co-regulated pilus biosynthesis protein Q C-terminal
Saccharopine dehydrogenase-like C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Helix-hairpin-helix DNA-binding motif class 1
Polymerase/histidinol phosphatase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
RNA polymerase sigma factor 70 region 4 type 2
Aminoacyl-transfer RNA synthetases class-II family profile
Beta-lactamase hydrolase-like protein phosphatase-like
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Reversibly protonated during proton transport
RNA binding; important for wobble base 34 recognition
P pilus assembly protein, chaperone PapD
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
TSP C-terminal domain-containing protein
Interacts with tRNA; defines subfamily-specific binding signature
O-(5'-phospho-DNA)-tyrosine intermediate
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Interaction with polymerase core subunit RpoC
Peptidase S9 prolyl oligopeptidase catalytic
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Large ribosomal subunit protein uL15/eL18
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Glucosamine/galactosamine-6-phosphate isomerase
Cation-transporting P-type ATPase N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
PHA accumulation regulator DNA-binding N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Flagellar hook-length control protein-like C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
Transposase IS116/IS110/IS902 C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
UDP N-acetylglucosamine O-acyltransferase C-terminal
RNA 2-O ribose methyltransferase substrate binding
Disulphide bond isomerase DsbC/G N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Heme-copper oxidase subunit III family profile
Solute-binding protein family 3/N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Nitrite/Sulfite reductase ferredoxin-like
Inner membrane protein YgaP-like transmembrane
Important for beta-aspartyl-AMP intermediate formation
Thymidylate synthase/dCMP hydroxymethylase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Type III secretion system flagellar brake protein YcgR PilZN
Proline utilization A proline dehydrogenase N-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Important for substrate binding and specificity
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
ABC-type uncharacterised transport system
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Cysteine sulfenic acid (-SOH) intermediate
Major facilitator superfamily (MFS) profile
Penicillin-binding protein transpeptidase
Large ribosomal subunit protein uL6 alpha-beta
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Alpha-glycerophosphate oxidase C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Tat (Twin-arginine translocation) pathway signal sequence domain protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Thiamin/hydroxymethyl pyrimidine-binding YkoF putative
Outer membrane protein beta-barrel domain-containing protein
Organic solvent tolerance-like N-terminal
N-end rule aminoacyl transferase C-terminal
Flagellar Assembly Protein A N-terminal region
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Poly-beta-hydroxybutyrate polymerase N-terminal
Arginine decarboxylase C-terminal helical
Glucose-methanol-choline oxidoreductase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Tryptophan synthase beta chain-like PALP
ABC-type transport auxiliary lipoprotein component
Gly-cisPro motif, important for rejection of L-amino acids
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Sodium/calcium exchanger membrane region
Alpha-D-phosphohexomutase alpha/beta/alpha
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Type II secretion system protein GspG C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Transcriptional regulator AbiEi antitoxin N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Translation elongation factor P/YeiP central
Anthranilate synthase component I N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Activator of Hsp90 ATPase homologue 1-like C-terminal
Glycoside hydrolase family 31 N-terminal
Prokaryotic-type class I peptide chain release factors
Peptidase S8/S53 domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
PhoD-like phosphatase metallophosphatase
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Large ribosomal subunit protein uL2 C-terminal
Alanyl-transfer RNA synthetases family profile
Cytochrome c-type biogenesis protein CcmF C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Plays an important role in discriminating NADH against NADPH
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Urease accessory protein UreH-like transmembrane
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Pyruvate phosphate dikinase AMP/ATP-binding
Release factor glutamine methyltransferase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Phosphate ABC transporter substrate-binding protein
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Type II secretion system protein GspI C-terminal
Bacterial type II secretion system protein E
Alpha-1,6-glucosidases pullulanase-type C-terminal
Glycoside hydrolase family 13 N-terminal
Pullulanase carbohydrate-binding module 41
Lytic transglycosylase superhelical linker
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Exonuclease VII large subunit C-terminal
6-phosphogluconate dehydrogenase C-terminal
Acyl-CoA dehydrogenase C-terminal bacterial-type
GlyGly-CTERM sorting domain-containing protein
N6 adenine-specific DNA methyltransferase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Important for interaction with partner proteins
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Chromosomal replication initiator protein DnaA
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
NADH:flavin oxidoreductase/NADH oxidase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Formamidopyrimidine-DNA glycosylase catalytic
Glycine cleavage T-protein C-terminal barrel
Non-canonical purine NTP phosphatase/PRRC1
Transition state stabilizer; via amide nitrogen
Pyruvate dehydrogenase E1 component middle
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Ribose-phosphate pyrophosphokinase N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-124)
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Bacterial virulence factor lipase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Sugar fermentation stimulation protein C-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Molybdopterin cofactor biosynthesis C (MoaC)
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Flagellar motor switch protein FliN-like C-terminal
Magnesium transporter MgtE intracellular
Electron transfer via tryptophanyl radical
Quercetin 2,3-dioxygenase C-terminal cupin
DNA mismatch repair proteins mutS family
Putative acyltransferase ACT14924-like acyltransferase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Sodium symporter small subunit predicted
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Outer-membrane lipoprotein carrier protein
Mechanosensitive ion channel inner membrane
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Erythronate-4-phosphate dehydrogenase dimerisation
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Prepilin type IV endopeptidase peptidase
Outer membrane protein assembly factor BamD
Mannose-6-phosphate isomerase type II C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Polysaccharide biosynthesis protein CapD-like
NIF system FeS cluster assembly NifU C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Plays an important role in substrate specificity
Type I restriction enzyme R protein N-terminal
PEP-CTERM sorting domain-containing protein
Outer membrane protein assembly factor BamA
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
NAD(P) transhydrogenase alpha subunit C-terminal
Glycoside hydrolase family 2 catalytic domain-containing protein
Inosine/uridine-preferring nucleoside hydrolase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
6-hydroxymethylpterin diphosphokinase MptE-like
Aminoacyl-tRNA synthetase class I anticodon-binding
DNA polymerase III subunit delta C-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
TonB system biopolymer transport component
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
High potential iron-sulfur proteins family profile
Outer membrane protein assembly factor BamB
Biopterin-dependent aromatic amino acid hydroxylase family profile
Positions MEP for the nucleophilic attack
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Putative adhesin domain-containing protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Lysidine-tRNA(Ile) synthetase C-terminal
tRNA(Ile)-lysidine synthase substrate-binding
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity