Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
TonB-dependent receptor-like beta-barrel
DNA replication/recombination mediator RecO N-terminal
Right handed beta helix domain-containing protein
Prokaryotic-type class I peptide chain release factors
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Alanyl-transfer RNA synthetases family profile
Cation-transporting P-type ATPase N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
FAD-dependent oxidoreductase 2 FAD binding
AB hydrolase-1 domain-containing protein
Reversibly protonated during proton transport
NarX-like N-terminal domain-containing protein
N-end rule aminoacyl transferase C-terminal
Outer membrane protein assembly factor BamA
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glycosyltransferase subfamily 4-like N-terminal
Signal transduction histidine kinase internal region
ABC-type transport auxiliary lipoprotein component
Essential for prephenate dehydratase activity
Membrane fusion protein biotin-lipoyl like
Membrane fusion protein biotin-lipoyl like domain-containing protein
Polysaccharide biosynthesis protein C-terminal
Inner membrane protein YgaP-like transmembrane
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Mechanosensitive ion channel family protein
Type II secretion system protein GspG C-terminal
NIF system FeS cluster assembly NifU N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Cysteine sulfenic acid (-SOH) intermediate
Sugar fermentation stimulation protein C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Heme-copper oxidase subunit III family profile
Doubled CXXCH motif domain-containing protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Polymerase/histidinol phosphatase N-terminal
Peptidase S8/S53 domain-containing protein
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Siroheme decarboxylase AsnC-like ligand binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Important for interaction with partner proteins
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
RNA polymerase sigma factor 70 region 4 type 2
RND efflux pump membrane fusion protein barrel-sandwich
Resolvase/invertase-type recombinase catalytic
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Tetrahydrodipicolinate-N-succinyltransferase chain A
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cytochrome c-552/4 domain-containing protein
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Interaction with polymerase core subunit RpoC
ABC-type transport auxiliary lipoprotein component domain-containing protein
Ankyrin repeat domain-containing protein
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Proton acceptor; for glutaminase activity
RNA 2-O ribose methyltransferase substrate binding
Organic solvent tolerance-like N-terminal domain-containing protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Type 4 fimbrial biogenesis protein PilX N-terminal
Choice-of-anchor D domain-containing protein
Dinitrogenase iron-molybdenum cofactor biosynthesis
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Bacterial type II secretion system protein E
Periplasmic copper-binding protein NosD beta helix
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Periplasmic nitrate reductase, electron transfer subunit
Could be important to modulate the pK values of the two catalytic cysteine residues
Solute-binding protein family 3/N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Polysaccharide biosynthesis protein CapD-like
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Autotransporter domain-containing protein
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Cytochrome b561 bacterial/Ni-hydrogenase
Putative beta-barrel assembly-enhancing protease
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Penicillin-binding protein transpeptidase
Outer membrane protein beta-barrel domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Major facilitator superfamily (MFS) profile
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Tryptophan synthase beta chain-like PALP
Important for beta-aspartyl-AMP intermediate formation
Large ribosomal subunit protein uL2 C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Peptidase M1 membrane alanine aminopeptidase
HicB-like antitoxin of toxin-antitoxin system
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Gamma-butyrobetaine hydroxylase-like N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Large ribosomal subunit protein uL6 alpha-beta
Alpha-D-phosphohexomutase alpha/beta/alpha
NADH:flavin oxidoreductase/NADH oxidase N-terminal
ABC-type uncharacterised transport system
Pyrimidine nucleoside phosphorylase C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Gly-cisPro motif, important for rejection of L-amino acids
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Metallo-beta-lactamase domain-containing protein
DNA-directed DNA polymerase family A palm
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Glycine cleavage T-protein C-terminal barrel
Thiol:disulfide interchange protein DsbD
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Urease accessory protein UreH-like transmembrane
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Nitrite/Sulfite reductase ferredoxin-like
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Glycosyl transferase family 3 N-terminal
Small ribosomal subunit protein uS4 N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Chromosomal replication initiator protein DnaA
UDP N-acetylglucosamine O-acyltransferase C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Phosphotransferase system enzyme I N-terminal
Translation elongation factor P/YeiP central
Outer membrane lipoprotein-sorting protein
Important for substrate specificity; cannot use PPi as phosphoryl donor
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
Beta-lactamase hydrolase-like protein phosphatase-like domain-containing protein
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Cytochrome oxidase subunit II copper A binding
Release factor glutamine methyltransferase N-terminal
DNA polymerase III subunit delta C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Peptide methionine sulphoxide reductase MsrA
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Interacts with tRNA; defines subfamily-specific binding signature
6-phosphogluconate dehydrogenase C-terminal
Sodium symporter small subunit predicted
Anthranilate synthase component I N-terminal
Plays an important role in substrate specificity
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Flagellar assembly protein FliH/Type III secretion system HrpE
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Exonuclease VII large subunit C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Disulphide bond isomerase DsbC/G N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Flagellar motor switch protein FliN-like C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
O-(3'-phospho-DNA)-tyrosine intermediate
Thymidylate synthase/dCMP hydroxymethylase
Pyruvate phosphate dikinase AMP/ATP-binding
Peptidase M3A/M3B catalytic domain-containing protein
Carbamoyl-phosphate synthase small subunit N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
RNA binding; important for wobble base 34 recognition
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Flavocytochrome c sulphide dehydrogenase flavin-binding
Pyruvate dehydrogenase E1 component middle
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Prepilin type IV endopeptidase peptidase
Cytochrome c7-like domain-containing protein
Large ribosomal subunit protein uL15/eL18
Ribose-phosphate pyrophosphokinase N-terminal
Putative regulatory protein FmdB Zinc ribbon
Lytic transglycosylase domain-containing protein
Gluconate 2-dehydrogenase subunit 3 family protein
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Chromosomal replication initiator DnaA C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Shikimate dehydrogenase substrate binding N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Interchain (with Cys-213); in linked form
Interchain (with Cys-54); in linked form
Surface antigen domain-containing protein
Peptidase S9 prolyl oligopeptidase catalytic
Survival protein SurE-like phosphatase/nucleotidase
SUF system FeS cluster assembly SufBD N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Molybdopterin cofactor biosynthesis C (MoaC)
Glycoside hydrolase family 57 N-terminal