Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with Met-252)
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-105)
Major facilitator superfamily (MFS) profile
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Flagellar hook-length control protein-like C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Exopolysaccharide production protein YjbE
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Molybdopterin cofactor biosynthesis C (MoaC)
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Polysaccharide chain length determinant N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Lysidine-tRNA(Ile) synthetase C-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Penicillin-binding protein activator LpoB
Glycosyltransferase subfamily 4-like N-terminal
Curli production assembly/transport component CsgF
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Important for interaction with partner proteins
Tellurite resistance methyltransferase TehB-like
Gly-cisPro motif, important for rejection of L-amino acids
Moves into active site upon enzyme activation, plays a role in electron transfer
DnaJ homologue subfamily C member 28 conserved
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
DNA-3-methyladenine glycosylase AlkA N-terminal
NIF system FeS cluster assembly NifU N-terminal
Important for beta-aspartyl-AMP intermediate formation
DNA-directed DNA polymerase family A palm
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Release factor glutamine methyltransferase N-terminal
Flagellar motor switch protein FliN-like C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
RND efflux pump membrane fusion protein barrel-sandwich
Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Mediates proton transfer from the protein to the inner aqueous phase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
RNA 2-O ribose methyltransferase substrate binding
Interacts with tRNA; defines subfamily-specific binding signature
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Threonine/serine exporter-like N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Glutathionylspermidine synthase pre-ATP-grasp-like
Involved in tetramerization or stability of the tetramer
Heme-copper oxidase subunit III family profile
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Cation-transporting P-type ATPase N-terminal
Tryptophan synthase beta chain-like PALP
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Cysteine sulfenic acid (-SOH) intermediate
Phosphoethanolamine transferase N-terminal
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Thymidylate synthase/dCMP hydroxymethylase
Arabinogalactan endo-beta-1,4-galactanase
ABC-type glycine betaine transport system substrate-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Positions MEP for the nucleophilic attack
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Outer membrane protein assembly factor BamA
SUF system FeS cluster assembly SufBD N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
6-phosphogluconate dehydrogenase C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Flagellar motor switch protein FliN N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Cob(I)alamin adenosyltransferase N-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Peptidase S9 prolyl oligopeptidase catalytic
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Interaction with polymerase core subunit RpoC
ABC-type transport auxiliary lipoprotein component
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Lytic transglycosylase superhelical linker
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Endo-type membrane-bound lytic murein transglycosylase A
Penicillin-binding protein transpeptidase
Rap1a immunity protein domain-containing protein
Bacteriophage lambda Replication protein O N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Curli production assembly/transport component CsgG
Translation elongation factor P/YeiP central
Multiple antibiotic resistance protein MarB
DNA mismatch repair proteins mutS family
Plays an important role in substrate specificity
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Polysaccharide biosynthesis protein CapD-like
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Phosphocysteine intermediate; for EIIB activity
Quercetin 2,3-dioxygenase C-terminal cupin
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
DNA polymerase III subunit delta C-terminal
TonB-dependent receptor-like beta-barrel
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Large ribosomal subunit protein bL25 L25
Seems to be a necessary countercharge to the potassium cations
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Transcription elongation factor GreA/GreB N-terminal
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
TtsA-like Glycoside hydrolase family 108
Chitobiase/beta-hexosaminidases N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Major facilitator superfamily associated
Penicillin-binding protein activator LpoA
Reversibly protonated during proton transport
D-galactose/methyl-galactoside binding periplasmic protein MglB
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
DNA-directed DNA polymerase family B multifunctional
Alanyl-transfer RNA synthetases family profile
RNA polymerase sigma factor 70 region 4 type 2
Terminase large subunit gp17-like C-terminal
Inosine/uridine-preferring nucleoside hydrolase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Transcriptional regulator SgrR N-terminal HTH
Could be important to modulate the pK values of the two catalytic cysteine residues
DNA polymerase III delta subunit C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Penicillin-insensitive murein endopeptidase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Ion-translocating oxidoreductase complex subunit G
Electron transfer via tryptophanyl radical
Proline utilization A proline dehydrogenase N-terminal
Required for dimer formation and molybdate binding
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Greasy slide, important in sugar transport
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Involved in allosteric activation by GTP
Bacterial type II secretion system protein E
Pseudouridine synthase I TruA alpha/beta
ATP synthase F1 complex delta/epsilon subunit N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Bacterial transcription activator effector binding
Sodium/calcium exchanger membrane region
Flagellar assembly protein FliH/Type III secretion system HrpE
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Type VI secretion system-associated protein
Glycosyl transferase family 3 N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Schiff-base intermediate with acetaldehyde
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Superoxide dismutase copper/zinc binding
O-(5'-phospho-DNA)-tyrosine intermediate
Prokaryotic-type class I peptide chain release factors
Integral membrane protein YccS N-terminal
Membrane fusion protein biotin-lipoyl like
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
NADH:ubiquinone oxidoreductase 30kDa subunit
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Type III secretion system flagellar brake protein YcgR PilZN
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Polymerase/histidinol phosphatase N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Bacterial CdiA-CT RNAse A domain-containing protein
Prepilin peptidase dependent protein C-like C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
L-seryl-tRNA selenium transferase N-terminal
Flagella basal body P-ring formation protein FlgA
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Could play a key role in the communication between the regulatory and the substrate sites
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Outer membrane assembly lipoprotein YfiO
Pyruvate dehydrogenase E1 component middle
Disulphide bond isomerase DsbC/G N-terminal
Exonuclease VII large subunit C-terminal
Important for substrate binding and specificity
Membrane insertase YidC/Oxa/ALB C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Aconitase A/isopropylmalate dehydratase small subunit swivel
Mannose-6-phosphate isomerase type II C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Glycoside hydrolase family 42 N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Essential for degradation by Lon protease
Outer membrane protein assembly factor BamE
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
RNA binding; important for wobble base 34 recognition
Carbamoyl-phosphate synthase small subunit N-terminal
NIF system FeS cluster assembly NifU C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Large ribosomal subunit protein uL15/eL18
Glycoside hydrolase family 31 N-terminal
Putative type VI secretion system Rhs element associated Vgr
Helix-hairpin-helix DNA-binding motif class 1
DNA replication/recombination mediator RecO N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glucan biosynthesis periplasmic MdoG C-terminal
Phosphotransferase system enzyme I N-terminal
Thiol:disulfide interchange protein DsbD N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Capsule biosynthesis GfcC-like C-terminal
Capsule biosynthesis GfcC-like N-terminal
Thiol:disulfide interchange protein DsbD
Essential for prephenate dehydratase activity
Glycine cleavage T-protein C-terminal barrel
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Glycine zipper domain-containing protein
Outer-membrane lipoprotein Wza C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Mechanosensitive ion channel inner membrane
Sugar fermentation stimulation protein C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
HicB-like antitoxin of toxin-antitoxin system
Type VI secretion system IcmF C-terminal
Appears to be important in orienting the phosphate for catalysis
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Outer membrane protein assembly factor BamD
For 3-hydroxyacyl-CoA dehydrogenase activity
Outer-membrane lipoprotein carrier protein
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Anthranilate synthase component I N-terminal
Serine/threonine specific protein phosphatases
UDP N-acetylglucosamine O-acyltransferase C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Pyruvate phosphate dikinase AMP/ATP-binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Erythronate-4-phosphate dehydrogenase dimerisation
Survival protein SurE-like phosphatase/nucleotidase
Translocation and assembly module subunit TamA
Small ribosomal subunit protein uS4 N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Aspartate/homoserine dehydrogenase NAD-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Curli production assembly/transport component CsgE
Non-canonical purine NTP phosphatase/PRRC1
Outer membrane protein assembly factor BamB
Large ribosomal subunit protein uL2 C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Peptide methionine sulphoxide reductase MsrA
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
RNA methyltransferase SpoU/TrmH type C-terminal
Prepilin type IV endopeptidase peptidase
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile