Interacts with tRNA; defines subfamily-specific binding signature
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
ATPsynthase alpha/beta subunit N-terminal extension
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Histidine-specific methyltransferase SAM-dependent
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Cytochrome P460 domain-containing protein
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
ABC-type uncharacterised transport system
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Gly-cisPro motif, important for rejection of L-amino acids
Release factor glutamine methyltransferase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
N6 adenine-specific DNA methyltransferase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Polysaccharide biosynthesis protein CapD-like
HicB-like antitoxin of toxin-antitoxin system
RND efflux pump membrane fusion protein barrel-sandwich
Membrane fusion protein biotin-lipoyl like
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Alpha-glycerophosphate oxidase C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Prokaryotic-type class I peptide chain release factors
Pyridine nucleotide-disulphide oxidoreductase dimerisation
NADH:ubiquinone oxidoreductase 30kDa subunit
Could play a key role in the communication between the regulatory and the substrate sites
Insertion element IS1 protein InsA helix-turn-helix
Exonuclease VII large subunit C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Transposase IS204/IS1001/IS1096/IS1165 DDE
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
May play a role in metal incorporation in vivo
Glucan biosynthesis periplasmic MdoG C-terminal
Type I restriction modification DNA specificity
Major facilitator superfamily (MFS) profile
Essential for prephenate dehydratase activity
Penicillin-binding protein transpeptidase
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Glycosyl transferase family 3 N-terminal
Type 4 fimbrial biogenesis protein PilX N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Aminoacyl-transfer RNA synthetases class-II family profile
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
peptide-methionine (R)-S-oxide reductase
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Heme-copper oxidase subunit III family profile
Cation-transporting P-type ATPase N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Phosphatidic acid phosphatase type 2/haloperoxidase
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
TonB-dependent receptor-like beta-barrel
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
PEP-CTERM protein-sorting domain-containing protein
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Resolvase/invertase-type recombinase catalytic
Alpha-L-glutamate ligase-related protein ATP-grasp
Bacterial type II secretion system protein E
Tetrahydrodipicolinate-N-succinyltransferase chain A
Cysteine sulfenic acid (-SOH) intermediate
SUF system FeS cluster assembly SufBD N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Large ribosomal subunit protein uL6 alpha-beta
Large ribosomal subunit protein uL2 C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Urease accessory protein UreH-like transmembrane
Reversibly protonated during proton transport
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Plays an important role in substrate specificity
Sugar fermentation stimulation protein C-terminal
6-phosphogluconate dehydrogenase C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Alpha-D-phosphohexomutase alpha/beta/alpha
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Probable transposase IS891/IS1136/IS1341
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Thiol:disulfide interchange protein DsbD
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Anthranilate synthase component I N-terminal
Glycine cleavage T-protein C-terminal barrel
Alanyl-transfer RNA synthetases family profile
Proline utilization A proline dehydrogenase N-terminal
Phosphoadenosine phosphosulphate reductase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Important for beta-aspartyl-AMP intermediate formation
Arginine decarboxylase C-terminal helical
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Interaction with polymerase core subunit RpoC
ATP synthase F1 complex delta/epsilon subunit N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Glycoside hydrolase family 57 N-terminal
Important for interaction with partner proteins
Gamma-butyrobetaine hydroxylase-like N-terminal
Large ribosomal subunit protein uL15/eL18
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Type II secretion system protein GspG C-terminal
Putative glycogen debranching enzyme N-terminal
Transglycosylase SLT domain-containing protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Prepilin type IV endopeptidase peptidase
Putative regulatory protein FmdB Zinc ribbon
Ribose-phosphate pyrophosphokinase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Polysaccharide chain length determinant N-terminal
Peptidase M12B domain-containing protein
Ribosomal RNA adenine methylase transferase N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
LPXTG cell wall anchor domain-containing protein
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Bacteriophage N4 adsorption protein A C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Phosphotransferase system enzyme I N-terminal
Polymerase/histidinol phosphatase N-terminal
DNA polymerase III delta subunit C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Cytochrome oxidase subunit II copper A binding
Putative ATP-dependent zinc protease domain-containing protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
NIF system FeS cluster assembly NifU N-terminal
Water stress and hypersensitive response
Pseudouridine synthase I TruA alpha/beta
DNA polymerase III subunit delta C-terminal
Pyruvate dehydrogenase E1 component middle
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Tryptophan synthase beta chain-like PALP
Mandelate racemase/muconate lactonizing enzyme C-terminal
DNA-directed DNA polymerase family A palm
Ysc84 actin-binding domain-containing protein
DNA replication/recombination mediator RecO N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
YMGG-like Gly-zipper domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
DNA mismatch repair proteins mutS family
Ribulose bisphosphate carboxylase small subunit
Flagellar hook-length control protein-like C-terminal
Organic solvent tolerance-like N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Bacterial OB-fold domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
Polysaccharide biosynthesis protein C-terminal
Neurotransmitter-gated ion-channel ligand-binding
Neurotransmitter-gated ion-channel transmembrane
Curli production assembly/transport component CsgG
Carbamoyl-phosphate synthase small subunit N-terminal
Exosortase system-associated protein, TIGR04073 family
Translation elongation factor P/YeiP central
Mechanosensitive ion channel inner membrane
Nitrite/Sulfite reductase ferredoxin-like
S-adenosyl-L-homocysteine hydrolase NAD binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Lipocalin-like domain-containing protein
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
ATP-grasp fold succinyl-CoA synthetase-type
Small ribosomal subunit protein uS4 N-terminal
Chromosomal replication initiator protein DnaA
Glutamate synthase alpha subunit C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Cytochrome oxidase subunit II transmembrane region profile
Glucosamine/galactosamine-6-phosphate isomerase
RNA binding; important for wobble base 34 recognition
TRAP C4-dicarboxylate transport system permease DctM subunit
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Myo-inositol-1-phosphate synthase GAPDH-like
Peptide methionine sulphoxide reductase MsrA
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
RNA polymerase sigma factor 70 region 4 type 2
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Hydrazine synthase alpha subunit middle domain-containing protein
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
N-end rule aminoacyl transferase C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Flagellar motor switch protein FliN-like C-terminal
Disulphide bond isomerase DsbC/G N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Positions MEP for the nucleophilic attack
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Carboxypeptidase regulatory-like domain-containing protein
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Flagellar assembly protein FliH/Type III secretion system HrpE
Required for zinc-mediated homotetramerization and catalytic activity
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Involved in allosteric activation by GTP
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glycine-zipper-containing OmpA-like membrane
Rap1a immunity protein domain-containing protein
Peptidase S9 prolyl oligopeptidase catalytic