Major facilitator superfamily (MFS) profile
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Positions MEP for the nucleophilic attack
Ribosomal RNA adenine methylase transferase N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Cytochrome oxidase subunit II copper A binding
Prokaryotic-type class I peptide chain release factors
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Aminoacyl-transfer RNA synthetases class-II family profile
Anthranilate synthase component I N-terminal
Cytochrome C biogenesis protein transmembrane
Large ribosomal subunit protein uL6 alpha-beta
Solute-binding protein family 3/N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Anti-bacteriophage protein A/HamA C-terminal
Transposase IS116/IS110/IS902 C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Resolvase/invertase-type recombinase catalytic
N6 adenine-specific DNA methyltransferase N-terminal
Phosphomannose isomerase type I catalytic
Membrane fusion protein biotin-lipoyl like
DNA primase/polymerase bifunctional N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Myo-inositol-1-phosphate synthase GAPDH-like
Inosine/uridine-preferring nucleoside hydrolase
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Gram-positive cocci surface proteins LPxTG
Pyridine nucleotide-disulphide oxidoreductase dimerisation
RNA 2-O ribose methyltransferase substrate binding
Gram-positive cocci surface proteins LPxTG domain-containing protein
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Peptidase M1 membrane alanine aminopeptidase
Glycosyltransferase 2-like prokaryotic type
Schiff-base intermediate with acetaldehyde
Translation elongation factor P/YeiP central
YbaK/aminoacyl-tRNA synthetase-associated
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Large ribosomal subunit protein uL15/eL18
Cytochrome b/b6 N-terminal region profile
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Penicillin-binding protein transpeptidase
Essential for prephenate dehydratase activity
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Thymidylate synthase/dCMP hydroxymethylase
ATP-dependent DNA helicase RecG C-terminal
Phosphoribosylformylglycinamidine synthase linker
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Trigger factor ribosome-binding bacterial
O-(3'-phospho-DNA)-tyrosine intermediate
Important for substrate specificity; cannot use PPi as phosphoryl donor
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Cell envelope-related transcriptional attenuator
Phosphatidic acid phosphatase type 2/haloperoxidase
Phenol hydroxylase C-terminal dimerisation
Peptidase S9 prolyl oligopeptidase catalytic
Phosphocysteine intermediate; for EIIB activity
DNA polymerase III delta subunit C-terminal
Glycosyl transferase family 3 N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Phosphatidate phosphatase APP1 catalytic
Bacterial transcription activator effector binding
6-phosphogluconate dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
RNA polymerase sigma factor 70 region 4 type 2
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Terminase large subunit-like endonuclease
CobB/CobQ-like glutamine amidotransferase
Protein O-mannosyl-transferase C-terminal four TM
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Exonuclease VII large subunit C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Increases nucleophilicity of active site Cys
Phosphotransferase system enzyme I N-terminal
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal
Release factor glutamine methyltransferase N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Polymerase/histidinol phosphatase N-terminal
Large ribosomal subunit protein uL2 C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
RNA binding; important for wobble base 34 recognition
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glycine cleavage T-protein C-terminal barrel
NIF system FeS cluster assembly NifU N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Resuscitation-promoting factor Rpf1 C-terminal
Resuscitation-promoting factor core lysozyme-like
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
L,D-transpeptidase catalytic domain-containing protein
Tryptophan synthase beta chain-like PALP
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Thiamine pyrophosphate enzyme TPP-binding
Membrane insertase YidC/Oxa/ALB C-terminal
Meso-diaminopimelate D-dehydrogenase C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Type I restriction modification DNA specificity
Endoribonuclease L-PSP/chorismate mutase-like
Reversibly protonated during proton transport
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Solute-binding protein family 3/N-terminal domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Small ribosomal subunit protein uS4 N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Phosphatidylglycerol lysyltransferase C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Peptidoglycan recognition protein family
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Prepilin type IV endopeptidase peptidase
Alpha-L-arabinofuranosidase B arabinose-binding
Nitrite/Sulfite reductase ferredoxin-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Plays an important role in substrate specificity
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Threonine/serine exporter-like N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Mandelate racemase/muconate lactonizing enzyme C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Transcription regulator AsnC/Lrp ligand binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Alanyl-transfer RNA synthetases family profile
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Pyruvate dehydrogenase E1 component middle
4'-phosphopantetheinyl transferase N-terminal
Gly-cisPro motif, important for rejection of L-amino acids