Helix-hairpin-helix DNA-binding motif class 1
Translation elongation factor P/YeiP central
Bacterial bifunctional deaminase-reductase C-terminal
Peptide methionine sulphoxide reductase MsrA
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Ionotropic glutamate receptor C-terminal
Ionotropic glutamate receptor L-glutamate and glycine-binding
Solute-binding protein family 3/N-terminal
Penicillin-binding protein transpeptidase
Pyrroline-5-carboxylate reductase catalytic N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Major facilitator superfamily (MFS) profile
6-phosphogluconate dehydrogenase C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Bacterial DNA polymerase III alpha subunit NTPase
DNA polymerase helix-hairpin-helix motif
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Ribose-phosphate pyrophosphokinase N-terminal
RNA binding; important for wobble base 34 recognition
Gram-positive pilin subunit D1 N-terminal
Tryptophan synthase beta chain-like PALP
Phosphatidic acid phosphatase type 2/haloperoxidase
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
O-(5'-phospho-DNA)-tyrosine intermediate
Reversibly protonated during proton transport
Transcriptional regulator TetR C-terminal Firmicutes type
Pyruvate phosphate dikinase AMP/ATP-binding
Cell envelope-related transcriptional attenuator
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
NAD(P) transhydrogenase alpha subunit C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Gram-positive pilin backbone subunit 2 Cna-B-like
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Phosphoribosylformylglycinamidine synthase linker
Resolvase/invertase-type recombinase catalytic
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Aminoacyl-transfer RNA synthetases class-II family profile
Plays an important role in substrate specificity
Chromosomal replication initiator DnaA C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Nicking enzyme C-terminal middle helical
Replication initiator protein A C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Bacterial type II secretion system protein E
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
NIF system FeS cluster assembly NifU N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
YbaK/aminoacyl-tRNA synthetase-associated
Inosine/uridine-preferring nucleoside hydrolase
RNA polymerase sigma factor 70 region 4 type 2
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Cation-transporting P-type ATPase N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Involved in allosteric activation by GTP
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Signal recognition particle SRP54 helical bundle
Pyrroline-5-carboxylate reductase dimerisation
Pyridoxamine 5'-phosphate oxidase putative
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Pseudouridine synthase I TruA alpha/beta
Sigma 54 modulation/S30EA ribosomal protein C-terminal
RNA 2-O ribose methyltransferase substrate binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Alanyl-transfer RNA synthetases family profile
Ribosomal RNA adenine methylase transferase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
CobB/CobQ-like glutamine amidotransferase
HicB-like antitoxin of toxin-antitoxin system
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Small ribosomal subunit protein uS4 N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Large ribosomal subunit protein uL2 C-terminal
DNA replication/recombination mediator RecO N-terminal
Exonuclease VII large subunit C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
SUF system FeS cluster assembly SufBD N-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Polysaccharide chain length determinant N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease 4
Glucosamine/galactosamine-6-phosphate isomerase
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Polymerase/histidinol phosphatase N-terminal
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Polysaccharide biosynthesis protein C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Peptidase M1 membrane alanine aminopeptidase
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Thymidylate synthase/dCMP hydroxymethylase
Choloylglycine hydrolase/NAAA C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glycoside hydrolase family 31 N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Schiff-base intermediate with D-ribose 5-phosphate
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
tRNA pseudouridylate synthase B C-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Phosphocysteine intermediate; for EIIB activity
ABC transporter substrate-binding protein PnrA-like
Important for interaction with partner proteins
Prokaryotic-type class I peptide chain release factors
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Gram-positive cocci surface proteins LPxTG
Large ribosomal subunit protein uL15/eL18
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Phosphotransferase system enzyme I N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Release factor glutamine methyltransferase N-terminal
X-Prolyl dipeptidyl aminopeptidase PepX N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Large ribosomal subunit protein uL6 alpha-beta
Sporulation transcription regulator WhiA N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose