Aminoacyl-transfer RNA synthetases class-II family profile
CobB/CobQ-like glutamine amidotransferase
Tetrahydromethanopterin S-methyltransferase F subunit
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Major facilitator superfamily (MFS) profile
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Glycogen debranching enzyme bacterial and archaeal type N-terminal
DNA-directed RNA polymerase RBP11-like dimerisation
Methanogenesis regulatory protein FilR1 middle
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Tryptophan synthase beta chain-like PALP
Alpha-D-phosphohexomutase alpha/beta/alpha
Cation-transporting P-type ATPase N-terminal
Polymerase/histidinol phosphatase N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Glycosyltransferase subfamily 4-like N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Glucose-6-phosphate isomerase prokaryote
Archaeal glycosylation protein B peripheral
Large ribosomal subunit protein uL15/eL18
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Transcription factor NikR nickel binding C-terminal
Small ribosomal subunit protein eS4 N-terminal
Small ribosomal subunit protein eS4 central region
Thiamine pyrophosphate enzyme TPP-binding
Formylmethanofuran dehydrogenase subunit E
Damage-control phosphatase ARMT1-like metal-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Pyrimidine nucleoside phosphorylase C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Ribosome maturation protein SDO1/SBDS C-terminal
Ribosome maturation protein SDO1/SBDS N-terminal
Ribosome maturation protein SDO1/SBDS central
HicB-like antitoxin of toxin-antitoxin system
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Alanyl-transfer RNA synthetases family profile
O-(3'-phospho-DNA)-tyrosine intermediate
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
DNA mismatch repair proteins mutS family
Helix-hairpin-helix DNA-binding motif class 1
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Protein-PII uridylyltransferase N-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Glycoside hydrolase family 57 N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Cytochrome b561 bacterial/Ni-hydrogenase
CRISPR-associated protein Cas6 C-terminal
6-hydroxymethylpterin diphosphokinase MptE-like
N6 adenine-specific DNA methyltransferase N-terminal
Bacterial type II secretion system protein E
Dihydroneopterin aldolase MtpD C-terminal
Increases nucleophilicity of active site Cys
Pyridine nucleotide-disulphide oxidoreductase dimerisation
tRNA nucleotidyltransferase substrate binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
Schiff-base intermediate with dihydroxyacetone-P
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Pyruvate/ketoisovalerate oxidoreductase catalytic
DNA polymerase II large subunit DP2 N-terminal
Removed in mature form; by autocatalysis
SAM-dependent methyltransferase TRM5/TYW2-type
ATPsynthase alpha/beta subunit N-terminal extension
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Prepilin type IV endopeptidase peptidase
Large ribosomal subunit protein uL2 C-terminal
RNA 3'-terminal phosphate cyclase insert
Ribosomal RNA adenine methylase transferase N-terminal
DNA-directed RNA polymerase subunit 2 hybrid-binding
Spo11/DNA topoisomerase VI subunit A N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Methyl-coenzyme M reductase alpha subunit C-terminal
Methyl-coenzyme M reductase alpha subunit N-terminal
Non-canonical purine NTP phosphatase/PRRC1
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Aldehyde ferredoxin oxidoreductase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Transcription regulator AsnC/Lrp ligand binding
O-(5'-phospho-DNA)-tyrosine intermediate
Small ribosomal subunit protein uS15 N-terminal
Probable transposase IS891/IS1136/IS1341
Inosine monophosphate cyclohydrolase-like
Small ribosomal subunit protein uS4 N-terminal
Methyl-coenzyme M reductase beta subunit C-terminal
Methyl-coenzyme M reductase beta subunit N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Important for beta-aspartyl-AMP intermediate formation
Butirosin biosynthesis protein H N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
RNA polymerase subunit H/Rpb5 C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Molybdopterin cofactor biosynthesis C (MoaC)
Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Large ribosomal subunit protein uL6 alpha-beta
Cytochrome C biogenesis protein transmembrane
NADH:ubiquinone oxidoreductase 30kDa subunit
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Sodium/calcium exchanger membrane region
Translation elongation factor IF5A C-terminal
Anthranilate synthase component I N-terminal
Pyruvoyl-dependent arginine decarboxylase subunit alpha
Pyruvoyl-dependent arginine decarboxylase subunit beta
Schiff-base intermediate with acetaldehyde
16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal
RNase L inhibitor RLI-like possible metal-binding
Proliferating cell nuclear antigen PCNA C-terminal
Proliferating cell nuclear antigen PCNA N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Carbamoyl-phosphate synthase small subunit N-terminal
Polysaccharide biosynthesis protein C-terminal
Signal recognition particle SRP54 helical bundle
Phosphoribosylformylglycinamidine synthase linker
Could be important to modulate the pK values of the two catalytic cysteine residues
Small zinc finger protein HVO-2753-like zinc-binding pocket
Large ribosomal subunit protein uL10-like insertion
Schiff-base intermediate with D-ribose 5-phosphate