Major facilitator superfamily (MFS) profile
RNA polymerase sigma factor 70 region 4 type 2
Activator of Hsp90 ATPase homologue 1-like C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Ribulose bisphosphate carboxylase small subunit
Heme-copper oxidase subunit III family profile
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glycine cleavage T-protein C-terminal barrel
Flagellar basal-body/hook protein C-terminal
Tryptophan synthase beta chain-like PALP
Mannose-6-phosphate isomerase type II C-terminal
Membrane fusion protein biotin-lipoyl like
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Phosphogluconate dehydrogenase (decarboxylating) C-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Could be important to modulate the pK values of the two catalytic cysteine residues
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Dinitrogenase iron-molybdenum cofactor biosynthesis
Saccharopine dehydrogenase-like C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Phosphatidic acid phosphatase type 2/haloperoxidase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Bacterial type II secretion system protein E
Organic solvent tolerance-like N-terminal
Solute-binding protein family 3/N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
TRAP C4-dicarboxylate transport system permease DctM subunit
Glutamate synthase alpha subunit C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Anaphase-promoting complex subunit 4-like WD40
Antitoxin Xre/MbcA/ParS-like toxin-binding
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Cysteine sulfenic acid (-SOH) intermediate
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Lysozyme inhibitor LprI N-terminal domain-containing protein
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Plasmid replication protein C C-terminal
Plasmid replication protein C N-terminal
TonB-dependent receptor-like beta-barrel
Penicillin-binding protein transpeptidase
DNA-directed DNA polymerase family A palm
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
NAD(P) transhydrogenase alpha subunit C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
UDP N-acetylglucosamine O-acyltransferase C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Glucose-methanol-choline oxidoreductase N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cobaltochelatase subunit CobS N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Cytochrome c oxidase subunit IV bacterial aa3 type
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Phosphoadenosine phosphosulphate reductase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Involved in allosteric activation by GTP
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Acyl-CoA dehydrogenase/oxidase C-terminal
Schiff-base intermediate with dihydroxyacetone-P
ABC-type glycine betaine transport system substrate-binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
S-adenosyl-L-homocysteine hydrolase NAD binding
General stress protein FMN-binding split barrel
ABC transporter substrate-binding protein
Flagellar motor switch protein FliN-like C-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Anthranilate synthase component I N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Superoxide dismutase copper/zinc binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Flagellar basal body rod protein N-terminal
Nucleophile; cysteine thiosulfonate intermediate
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Type I restriction modification DNA specificity
Alpha-D-phosphohexomutase alpha/beta/alpha
Phosphodiester glycosidase domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Peptidase S9 prolyl oligopeptidase catalytic
Polysaccharide biosynthesis protein C-terminal
Interaction with polymerase core subunit RpoC
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Pyrimidine nucleoside phosphorylase C-terminal
Adenylyl/Guanylyl and SMODS C-terminal sensor
Ionotropic glutamate receptor C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Flagella basal body P-ring formation protein FlgA
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Thymidylate synthase/dCMP hydroxymethylase
5-glutamyl coenzyme A thioester intermediate
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Flagellar hook-length control protein-like C-terminal
Cytochrome C biogenesis protein transmembrane
Small ribosomal subunit protein uS4 N-terminal
Methionyl-tRNA synthetase anticodon-binding
DNA replication/recombination mediator RecO N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Chromosomal replication initiator DnaA C-terminal
Survival protein SurE-like phosphatase/nucleotidase
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Na+/H+ antiporter MnhB subunit-related protein
Bacterial bifunctional deaminase-reductase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
N-sulphoglucosamine sulphohydrolase C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Prokaryotic-type class I peptide chain release factors
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
DNA mismatch repair proteins mutS family
Lipocalin-like domain-containing protein
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Glycoside hydrolase family 38 N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Tat pathway signal sequence domain protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Phosphoribosylformylglycinamidine synthase linker
CobB/CobQ-like glutamine amidotransferase
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Pyrroline-5-carboxylate reductase catalytic N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Exonuclease VII large subunit C-terminal
N-end rule aminoacyl transferase C-terminal
Glycosyl transferase family 3 N-terminal
PhoD-like phosphatase metallophosphatase
Type IV conjugative transfer protein TrbJ/K C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Reversibly protonated during proton transport
Phosphoethanolamine transferase N-terminal
Proton acceptor; for glutaminase activity
Glycosyltransferase subfamily 4-like N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-97)
Protein-L-isoaspartate O-methyltransferase
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Molybdopterin cofactor biosynthesis C (MoaC)
RNA 2-O ribose methyltransferase substrate binding
Cytochrome c-type biogenesis protein CcmF C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
O-(5'-phospho-DNA)-tyrosine intermediate
Gp5/Type VI secretion system Vgr protein OB-fold
Putative glycogen debranching enzyme N-terminal
Invasion associated locus B family protein
Required for zinc-mediated homotetramerization and catalytic activity
Tetrahydrodipicolinate-N-succinyltransferase chain A
Schiff-base intermediate with substrate; via pyruvic acid
Type VI secretion system IcmF C-terminal
Glycosyl transferase family 28 C-terminal
NIF system FeS cluster assembly NifU N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Large ribosomal subunit protein uL2 C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Polysaccharide chain length determinant N-terminal
YMGG-like Gly-zipper domain-containing protein
Thiamin pyrophosphokinase thiamin-binding
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Glycosyltransferase 2-like prokaryotic type
Nitrite/Sulfite reductase ferredoxin-like
PHA accumulation regulator DNA-binding N-terminal
Proline utilization A proline dehydrogenase N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Guanylate kinase/L-type calcium channel beta subunit
Probable periplasmic serine endoprotease DegP-like
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Translation elongation factor P/YeiP central
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
SUF system FeS cluster assembly SufBD N-terminal
Prepilin type IV endopeptidase peptidase
Large ribosomal subunit protein uL6 alpha-beta
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Resolvase/invertase-type recombinase catalytic
Phosphotransferase system enzyme I N-terminal
Sodium/calcium exchanger membrane region
O-(3'-phospho-DNA)-tyrosine intermediate
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Cob(I)alamin adenosyltransferase N-terminal
DNA topoisomerase I catalytic core eukaryotic-type
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
CagE TrbE VirB component of type IV transporter system central
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
CDP-alcohol phosphatidyltransferase C-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Glucosamine/galactosamine-6-phosphate isomerase
ABC transporter substrate-binding protein PnrA-like
Heat-inducible transcription repressor HrcA C-terminal
Pseudouridine synthase I TruA alpha/beta
Alkaline proteinase inhibitor/ Outer membrane lipoprotein Omp19
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Transglutaminase-like cysteine peptidase protein
Adaptive response protein AidB N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Polymerase/histidinol phosphatase N-terminal
Important for interaction with partner proteins
Pyrroline-5-carboxylate reductase dimerisation
Glucose-methanol-choline oxidoreductase C-terminal
Glycosyltransferase family 28 N-terminal
RNA binding; important for wobble base 34 recognition
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Membrane insertase YidC/Oxa/ALB C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Release factor glutamine methyltransferase N-terminal
Xaa-Pro dipeptidyl-peptidase-like domain-containing protein
Glycosyl hydrolases family 2 sugar binding
N6 adenine-specific DNA methyltransferase N-terminal
Beta-hexosaminidase bacterial type N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Chromosomal replication initiator protein DnaA
Peptide methionine sulphoxide reductase MsrA
Carboxypeptidase regulatory-like domain-containing protein
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Signal transduction histidine kinase HWE region
Lipopolysccharide assembly LptE family protein
Endoribonuclease L-PSP/chorismate mutase-like
Outer membrane protein assembly factor BamA
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cytochrome b561 bacterial/Ni-hydrogenase
Poly-beta-hydroxybutyrate polymerase N-terminal
Putative Flp pilus-assembly TadG-like N-terminal
Hydrazine synthase alpha subunit middle domain-containing protein
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Pyridoxamine 5'-phosphate oxidase putative
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Alanyl-transfer RNA synthetases family profile
Major facilitator superfamily associated
Plays an important role in substrate specificity
Beta-lactamase hydrolase-like protein phosphatase-like
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr C-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Large ribosomal subunit protein uL15/eL18
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Nitrogenase molybdenum-iron protein beta chain N-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
Pyruvate phosphate dikinase AMP/ATP-binding
HupH hydrogenase expression protein C-terminal
Essential for prephenate dehydratase activity
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Yop protein translocation protein D periplasmic
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Moybdenum cofactor oxidoreductase dimerisation
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
NADH-rubredoxin oxidoreductase C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Phosphatidylglycerol lysyltransferase C-terminal
Increases nucleophilicity of active site Cys