Peptidase M1 membrane alanine aminopeptidase
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
6-phosphogluconate dehydrogenase NADP-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Major facilitator superfamily (MFS) profile
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Cell envelope-related transcriptional attenuator
Putative regulatory protein FmdB Zinc ribbon
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Tryptophan synthase beta chain-like PALP
RNA polymerase sigma factor 70 region 4 type 2
Penicillin-binding protein transpeptidase
NADH-rubredoxin oxidoreductase C-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Erythromycin biosynthesis protein CIII-like central
Glycosyltransferase subfamily 4-like N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Mandelate racemase/muconate lactonizing enzyme C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
SUF system FeS cluster assembly SufBD N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Ricin B lectin domain-containing protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Pyridoxamine 5'-phosphate oxidase putative
Cytochrome bc1 complex Rieske iron-sulfur subunit
Gram-positive cocci surface proteins LPxTG
Important for beta-aspartyl-AMP intermediate formation
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-128)
Transcription regulator AsnC/Lrp ligand binding
Anthranilate synthase component I N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Nitrite/Sulfite reductase ferredoxin-like
Peptidase S9 prolyl oligopeptidase catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
DNA primase/polymerase bifunctional N-terminal
Proton acceptor; for glutaminase activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Cytochrome oxidase subunit II copper A binding
Gp5/Type VI secretion system Vgr protein OB-fold
Formamidopyrimidine-DNA glycosylase catalytic
NADH:ubiquinone oxidoreductase 30kDa subunit
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Carboxypeptidase regulatory-like domain-containing protein
Thiopeptide-type bacteriocin biosynthesis
Biopterin-dependent aromatic amino acid hydroxylase family profile
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Beta-lactamase class A catalytic domain-containing protein
Polymerase/histidinol phosphatase N-terminal
EfeO-type cupredoxin-like domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Solute-binding protein family 5 domain-containing protein
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
SGNH hydrolase-type esterase domain-containing protein
Bacterial bifunctional deaminase-reductase C-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
YbaK/aminoacyl-tRNA synthetase-associated
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Activator of Hsp90 ATPase homologue 1-like C-terminal
ABC-type glycine betaine transport system substrate-binding
Glycoside hydrolase family 31 N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Right-handed parallel beta-helix repeat-containing protein
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Histidine-specific methyltransferase SAM-dependent
Solute-binding protein family 3/N-terminal
CobB/CobQ-like glutamine amidotransferase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Schiff-base intermediate with dihydroxyacetone-P
PhoD-like phosphatase metallophosphatase
Alpha-L-arabinofuranosidase B arabinose-binding
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Twin-arginine translocation signal domain-containing protein
DNA topoisomerase I catalytic core eukaryotic-type
Acetylserotonin O-methyltransferase dimerisation
DNA replication/recombination mediator RecO N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Nicotinate phosphoribosyltransferase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Phosphocysteine intermediate; for EIIB activity
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
N,N-dimethylformamidase beta subunit-like C-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
DNA-directed DNA polymerase family A palm
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Quinolinate phosphoribosyl transferase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Septum formation-related domain-containing protein
Inosine/uridine-preferring nucleoside hydrolase
6-phosphogluconate dehydrogenase C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Phosphotransferase system enzyme I N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
NlpE C-terminal OB domain-containing protein
Resolvase/invertase-type recombinase catalytic
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Methionyl-tRNA synthetase anticodon-binding
4'-phosphopantetheinyl transferase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Lantibiotic biosynthesis protein dehydration
Glycoside hydrolase family 42 N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Type VII secretion system protein EssD-like
Glycine cleavage T-protein C-terminal barrel
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Polysaccharide lyase 8 N-terminal alpha-helical
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Prokaryotic-type class I peptide chain release factors
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Pyrimidine nucleoside phosphorylase C-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Phosphoribosylformylglycinamidine synthase linker
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Ionotropic glutamate receptor C-terminal
Release factor glutamine methyltransferase N-terminal
Contractile injection system tube protein N-terminal
ABC transporter substrate-binding protein PnrA-like
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Plays an important role in substrate specificity
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Streptomyces killer toxin-like beta/gamma crystallin domain-containing protein
Glycosyl transferase family 3 N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Peptide methionine sulphoxide reductase MsrA
Heat-inducible transcription repressor HrcA C-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Nuclear transport factor 2 family protein
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Carbamoyl-phosphate synthase small subunit N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Transposase IS116/IS110/IS902 C-terminal
Cytochrome C biogenesis protein transmembrane
Cation-transporting P-type ATPase N-terminal
Endonuclease/exonuclease/phosphatase family protein
Methylguanine DNA methyltransferase ribonuclease-like
Interaction with polymerase core subunit RpoC
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Aconitase A/isopropylmalate dehydratase small subunit swivel
CD-NTase-associated protein 12/Pycsar effector protein TIR
Small ribosomal subunit protein uS4 N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
vWA-MoxR associated protein middle region 0
Large ribosomal subunit protein uL6 alpha-beta
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Alpha-glycerophosphate oxidase C-terminal
AMP-activated protein kinase glycogen-binding
Beta-hexosaminidase bacterial type N-terminal
Large ribosomal subunit protein uL2 C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Lactate utilization protein B C-terminal
Putative glycogen debranching enzyme N-terminal
Chromosomal replication initiator DnaA C-terminal
Na+/H+ antiporter MnhB subunit-related protein
NIF system FeS cluster assembly NifU N-terminal
Glycoside hydrolase family 42 N-terminal domain-containing protein
Could play a key role in the communication between the regulatory and the substrate sites
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Adaptive response protein AidB N-terminal
L-seryl-tRNA selenium transferase N-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
RlpA-like protein double-psi beta-barrel
Phosphatidylglycerol lysyltransferase C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Peptidase S8/S53 domain-containing protein
Anti-sigma-D factor RsdA sigma factor binding region
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Polyketide synthase phosphopantetheine-binding
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Bacterial spore germination immunoglobulin-like domain-containing protein
LPXTG cell wall anchor domain-containing protein
Molybdopterin cofactor biosynthesis C (MoaC)
ATP synthase F1 complex delta/epsilon subunit N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Styrene monooxygenase StyA putative substrate binding
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Endoribonuclease L-PSP/chorismate mutase-like
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Dihydrodipicolinate reductase C-terminal
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Dihydrodipicolinate reductase N-terminal
Phosphomannose isomerase type I catalytic
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Bacterial type II secretion system protein E
Acyltransferase MbtK/IucB-like conserved
Centromere-binding protein ParB C-terminal
Alanyl-transfer RNA synthetases family profile
Myo-inositol-1-phosphate synthase GAPDH-like
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Large ribosomal subunit protein uL15/eL18
PsrA tetracyclin repressor-like C-terminal
Translation elongation factor P/YeiP central
Helix-hairpin-helix DNA-binding motif class 1
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptidase C-terminal archaeal/bacterial domain-containing protein
Positions MEP for the nucleophilic attack
Sporulation transcription regulator WhiA N-terminal
Removed in mature form; by autocatalysis
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Alginate lyase domain-containing protein
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Arabinogalactan endo-beta-1,4-galactanase
3-beta hydroxysteroid dehydrogenase/isomerase
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Copper type II ascorbate-dependent monooxygenase C-terminal