Glucose-methanol-choline oxidoreductase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Prokaryotic-type class I peptide chain release factors
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Important for interaction with partner proteins
Interaction with polymerase core subunit RpoC
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Major facilitator superfamily (MFS) profile
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Activator of Hsp90 ATPase homologue 1-like C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
N-sulphoglucosamine sulphohydrolase C-terminal
Flagellar basal body-associated FliL family protein
Poly-beta-hydroxybutyrate polymerase N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Mandelate racemase/muconate lactonizing enzyme C-terminal
Membrane fusion protein biotin-lipoyl like
Survival protein SurE-like phosphatase/nucleotidase
Flagellar motor switch protein FliN-like C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Acyl-CoA dehydrogenase/oxidase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Transposase IS116/IS110/IS902 C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Glycosyltransferase subfamily 4-like N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Inosine/uridine-preferring nucleoside hydrolase
Acyl-CoA dehydrogenase/oxidase C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Outer membrane protein assembly factor BamA
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Electron transfer flavoprotein alpha/beta-subunit N-terminal
HicB-like antitoxin of toxin-antitoxin system
Putative Flp pilus-assembly TadG-like N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Signal transduction histidine kinase HWE region
PHA accumulation regulator DNA-binding N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Sodium/calcium exchanger membrane region
Aminoacyl-transfer RNA synthetases class-II family profile
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Pseudouridine synthase I TruA alpha/beta
Endoribonuclease L-PSP/chorismate mutase-like
SUF system FeS cluster assembly SufBD N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Pyrroline-5-carboxylate reductase catalytic N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Polysaccharide biosynthesis protein C-terminal
Penicillin-binding protein transpeptidase
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Heme-copper oxidase subunit III family profile
Release factor glutamine methyltransferase N-terminal
Electron transfer via tryptophanyl radical
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
ABC transporter substrate-binding protein PnrA-like
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Alpha-D-phosphohexomutase alpha/beta/alpha
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Solute-binding protein family 3/N-terminal
Transcription regulator AsnC/Lrp ligand binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Polysaccharide chain length determinant N-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Tryptophan synthase beta chain-like PALP
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Chromosomal replication initiator DnaA C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
RNA binding; important for wobble base 34 recognition
Probable periplasmic serine endoprotease DegP-like
Outer membrane protein assembly factor BamD
PsrA tetracyclin repressor-like C-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-95)
Antitoxin Xre/MbcA/ParS-like toxin-binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glycosyl transferase family 3 N-terminal
6-phosphogluconate dehydrogenase C-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Polymerase/histidinol phosphatase N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Surface antigen domain-containing protein
NIF system FeS cluster assembly NifU N-terminal
Transcription elongation factor GreA/GreB C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
TonB-dependent receptor-like beta-barrel
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Proton acceptor; for glutaminase activity
RNA 2-O ribose methyltransferase substrate binding
4'-phosphopantetheinyl transferase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
NAD(P) transhydrogenase alpha subunit C-terminal
Transcription elongation factor GreA/GreB N-terminal
Large ribosomal subunit protein uL15/eL18
Glycine cleavage T-protein C-terminal barrel
Anthranilate synthase component I N-terminal
Aldehyde oxidase/xanthine dehydrogenase first molybdopterin binding
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
High-affinity zinc uptake system protein ZnuA
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Large ribosomal subunit protein uL2 C-terminal
Sugar fermentation stimulation protein C-terminal
Translation elongation factor P/YeiP central
CASTOR/POLLUX/SYM8 ion channel conserved
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Small ribosomal subunit protein uS4 N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Essential for prephenate dehydratase activity
DNA replication/recombination mediator RecO N-terminal
Thymidylate synthase/dCMP hydroxymethylase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
N-end rule aminoacyl transferase C-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Ionotropic glutamate receptor C-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
peptide-methionine (R)-S-oxide reductase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Involved in allosteric activation by GTP
NADH-rubredoxin oxidoreductase C-terminal
General stress protein FMN-binding split barrel
2,4-diaminopentanoate dehydrogenase C-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Membrane insertase YidC/Oxa/ALB C-terminal
Phosphoribosylformylglycinamidine synthase linker
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
6-phosphogluconate dehydrogenase NADP-binding
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Cobaltochelatase subunit CobS N-terminal
Moybdenum cofactor oxidoreductase dimerisation
ABC-type glycine betaine transport system substrate-binding
Peptidase C39-like domain-containing protein
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Peptide methionine sulphoxide reductase MsrA
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Dinitrogenase iron-molybdenum cofactor biosynthesis
Pyrroline-5-carboxylate reductase dimerisation
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Glycine zipper domain-containing protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Phosphatidylglycerol lysyltransferase C-terminal
Involved in tetramerization or stability of the tetramer
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Bacterial type II secretion system protein E
Type VI secretion system IcmF C-terminal
Organic solvent tolerance-like N-terminal
Plays an important role in substrate specificity
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Chromosomal replication initiator protein DnaA
Mannose-6-phosphate isomerase type II C-terminal
Periplasmic copper-binding protein NosD beta helix
Adaptive response protein AidB N-terminal
Glycoside hydrolase family 42 N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Glucosamine/galactosamine-6-phosphate isomerase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
Histidine phosphotransferase ChpT C-terminal
Alanyl-transfer RNA synthetases family profile
Nitrogenase molybdenum-iron protein beta chain N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Exonuclease VII large subunit C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Alpha-glycerophosphate oxidase C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Peptide methionine sulfoxide reductase MsrA
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Cytochrome c-type biogenesis protein CcmF C-terminal
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Peptidase S9 prolyl oligopeptidase catalytic
Saccharopine dehydrogenase-like C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Neutral/alkaline non-lysosomal ceramidase N-terminal
Cytochrome C biogenesis protein transmembrane
NADH:ubiquinone oxidoreductase-like 20kDa subunit
NADH:ubiquinone oxidoreductase 30kDa subunit
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
5'-3' exonuclease alpha-helical arch N-terminal
Transcriptional regulator AbiEi antitoxin N-terminal
Phenol hydroxylase C-terminal dimerisation
Could play a key role in the communication between the regulatory and the substrate sites
CDP-alcohol phosphatidyltransferase C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Reversibly protonated during proton transport
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Required for zinc-mediated homotetramerization and catalytic activity
Methionyl-tRNA synthetase anticodon-binding
Serine/threonine specific protein phosphatases
Flagella basal body P-ring formation protein FlgA
Gp5/Type VI secretion system Vgr protein OB-fold
Cysteine sulfenic acid (-SOH) intermediate
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Alkaline proteinase inhibitor/ Outer membrane lipoprotein Omp19
Tetrahydrodipicolinate-N-succinyltransferase chain A
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
RlpA-like protein double-psi beta-barrel
Cytochrome c oxidase subunit IV bacterial aa3 type