Interchain (between light and heavy chains)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
SUMO interaction motif 1 (SIM); mediates the binding to polysumoylated substrates
SUMO interaction motif 2 (SIM); mediates the binding to polysumoylated substrates
Piezo non-specific cation channel R-Ras-binding
Piezo-type mechanosensitive ion channel component 1
G-protein coupled receptors family 1 profile
18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
Cleavage/polyadenylation specificity factor A subunit C-terminal
Cleavage/polyadenylation specificity factor A subunit N-terminal
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
Transcription elongation factor Eaf N-terminal
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Neurotrophin receptor-interacting factor 1
Induces a redistribution from both the nucleus and cytoplasm to only the cytoplasm.
Major facilitator superfamily (MFS) profile
Flexible and important for F-actin binding
GTP-binding nuclear protein Ran, testis-specific isoform
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Breast cancer metastasis-suppressor 1 homolog
Cell cycle exit and neuronal differentiation protein 1
Helical; Anchor for type IV membrane protein
Almost abolishes interaction with IQSEC1; when associated with V-876. Abolishes activation of ARF6 by IQSEC1; when associated with V-876.
Almost abolishes interaction with IQSEC1; when associated with Y-875. Abolishes activation of ARF6 by IQSEC1; when associated with Y-875.
Crucial to convey clamshell closure to channel opening
Interaction with the cone snail toxin Con-ikot-ikot
Promotes dimerization. Strongly reduced desensitization.
Strongly decreases interaction with IQSEC1. Abolishes activation of ARF6 by IQSEC1.
Cation-transporting P-type ATPase N-terminal
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
RAC-beta serine/threonine-protein kinase
Small ribosomal subunit protein eS27-like
Translation elongation factor IF5A C-terminal
BMP/retinoic acid-inducible neural-specific protein 1
Bicarbonate transporter-like transmembrane
In isoform 2, isoform 3, isoform 10, isoform 11 and isoform 12.
In isoform 2, isoform 3, isoform 4, isoform 6, isoform 7, isoform 8, isoform 10 and isoform 12.
In isoform 2, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 10 and isoform 12.
In isoform 8, isoform 9, isoform 10 and isoform 11.
Sodium-driven chloride bicarbonate exchanger
Transmembrane protein 127 transmembrane region
Reduced RNA editing activity; when associated with A-128.
Reduced RNA editing activity; when associated with A-281.
Helical; Voltage-sensor; Name=Segment S4
Potassium voltage-gated channel subfamily V member 1
Abolishes NMDA receptor-dependent long-lasting depression.
Dominant negative. Abolishes depression of AMPAR-mediated transmission. Abolishes NMDA receptor-dependent long-lasting depression.
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
N6-(pyridoxal phosphate)lysine; alternate
Important for interaction with ATG13 and for autophagosome formation
Microtubule-associated proteins 1A/1B light chain 3A
Phosphatidylethanolamine amidated glycine; alternate
Phosphatidylserine amidated glycine; alternate
Guanine nucleotide-binding protein subunit alpha-15
Acyl-coenzyme A synthetase ACSM3, mitochondrial
Peptidase M20 dimerisation domain-containing protein
Marginal zone B- and B1-cell-specific protein
Impairs Gpm6a-induced filopodium formation.
Impairs synaptic density in primary hippocampal neurons; when associated with A-174.
Impairs synaptic density in primary hippocampal neurons; when associated with A-192.
Reduces motility of Gpm6a-induced filopodia; when associated with A-10, A-256 and A-267.
Reduces motility of Gpm6a-induced filopodia; when associated with A-10, A-256 and A-268.
Reduces motility of Gpm6a-induced filopodia; when associated with A-10, A-267 and A-268.
Reduces motility of Gpm6a-induced filopodia; when associated with A-256, A-267 and A-268.
No effect on myosin incorporation into sarcomeres.
No effect on myosin incorporation into sarcomeres. Causes myosin cytoplasmic aggregates that show a sponge-like structure.
No effect on myosin incorporation into sarcomeres. Disrupts location on the sarcomere bare zone.
Abolished serine/threonine-protein kinase activity and ability to phosphorylate OXSR1/OSR1 and STK39/SPAK; when associated with A-183.
Abolished serine/threonine-protein kinase activity and ability to phosphorylate OXSR1/OSR1 and STK39/SPAK; when associated with A-318.
non-specific serine/threonine protein kinase
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Platelet-derived growth factor (PDGF) family profile
Glycine cleavage T-protein C-terminal barrel
Zinc finger CCHC domain-containing protein 12
G-protein coupled receptors family 3 profile
Choline/ethanolaminephosphotransferase 1
Heterogeneous nuclear ribonucleoprotein A1
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
N-acetylserine; in Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Requires for dimerization and lipid rafts association
Requires for interaction with MSN and EZR
MAP/microtubule affinity-regulating kinase 3
Coiled-coil domain-containing protein 32
STE20-like serine/threonine-protein kinase
20% of wild-type transporter activity. No effect on cell membrane localization.
40% of wild-type transporter activity. No effect on cell membrane localization.
60% of wild-type transporter activity. No effect on cell membrane localization.
Electroneutral sodium bicarbonate exchanger 1
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Sufficient for self-association and interaction with TARBP2
Large ribosomal subunit protein uL10-like insertion
Subject to oxidation and hydroselenide loss to dehydroalanine
LHFPL tetraspan subfamily member 4 protein
Basic leucine zipper transcriptional factor ATF-like
Anaphase-promoting complex subunit 4-like WD40
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Mediator of DNA damage checkpoint protein 1
Histone deacetylase glutamine rich N-terminal
Cytoskeleton-associated protein 2 C-terminal
Peptide chain release factor 1-like, mitochondrial
S-farnesyl cysteine; in plasma membrane form
S-geranylgeranyl cysteine; in endosomal form
Required for interaction with NUMA1 and regulation of apoptosis in response to DNA damage
Inositol 1,4,5-trisphosphate receptor type 2
Secretory carrier-associated membrane protein 5
Essential for phosphatidylinositol-4-phosphate phosphatase activity
Reduces phosphatase activity towards PtdIns(4)P, but not towards PtdIns(3)P or PtdIns(3,5)P2.
Required for homodimerization and for interaction with CRY1 and CHEK1
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
Aflatoxin B1 aldehyde reductase member 2
Tumor protein p53-inducible nuclear protein 1
Translocon-associated protein subunit alpha
Required for role in regulation of RANKL-induced osteoclast differentiation
Increased affinity for serotonin and tyramine.
Important for obstruction of the ion pore in the closed conformation
Neurotransmitter-gated ion-channel ligand-binding
Neurotransmitter-gated ion-channel transmembrane
Gamma-aminobutyric acid receptor-associated protein-like 2
Coiled-coil domain-containing protein 90B, mitochondrial
5-glutamyl glycerylphosphorylethanolamine
N6,N6,N6-trimethyllysine; alternate; by EEF1AKMT3
4-hydroxyphenylpyruvate dioxygenase-like protein
Decreased association with HDAC1; when associated with A-772 and A-780.
Decreased association with HDAC1; when associated with A-772 and A-787.
Decreased association with HDAC1; when associated with A-780 and A-787.
Domain C; mediates interaction with E4F1
Kinase D-interacting substrate of 220 kDa
Loss of binding to PDZ domain of SNTA1 and SNTB2.
Trafficking protein particle complex subunit 11
Trafficking protein particle complex subunit 11 C-terminal
ADP-ribosylation factor GTPase-activating protein 3
Membrane insertase YidC/Oxa/ALB C-terminal
Decreases the catalytic efficiency toward menadione and nitrobenzene substrates.
Decreases the catalytic efficiency toward menadione. Has no effect on the catalytic efficiency toward nitrobenzene substrate.
Has no effect on the catalytic efficiency toward menadione and nitrobenzene substrates.
Has no effect on the catalytic efficiency toward menadione. Slightly decreases the catalytic efficiency toward nitrobenzene substrate.
Important for apoenzyme conformational stability
Induces a very low catalytic efficiency.
Impaired ability to regulate alternative splicing of Ttn (Titin) mRNAs. Decreased localization to the nucleus associated with an increased localization to cytoplasmic ribonucleoprotein granules.
Mimics phosphorylation; does not restore nuclear localization.
No effect; does not affect ability to regulate alternative splicing.
Sodium/calcium exchanger membrane region
Coiled-coil domain-containing protein 174
Cocaine is effective at blocking transport.
Disrupts chloride ion dependence of serotonin transport.
Disrupts chloride ion dependence of serotonin transport; when associated with A-101.
Sodium:neurotransmitter symporter serotonin N-terminal
Solute carrier family 52, riboflavin transporter, member 3
Tumour necrosis factor receptor 13C TALL-1 binding
Voltage-dependent calcium channel gamma-6 subunit
Migration and invasion-inhibitory protein
TRAF-interacting protein with FHA domain-containing protein A
Cyclic AMP-responsive element-binding protein 3-like protein 4
Helical; Signal-anchor for type II membrane protein
Processed cyclic AMP-responsive element-binding protein 3-like protein 4
Glycerol-3-phosphate acyltransferase 1, mitochondrial
Gamma-aminobutyric acid receptor subunit beta-2
Ras association domain-containing protein 2
Dihydroxyacetone phosphate acyltransferase
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Coiled-coil and C2 domain-containing protein 1A
Molybdopterin synthase catalytic subunit
TRF2-interacting telomeric protein/Rap1 C-terminal
Telomeric repeat-binding factor 2-interacting protein 1
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
Leucine-rich repeat flightless-interacting protein 1
Kelch repeat and BTB domain-containing protein 8
ATP-dependent 6-phosphofructokinase, liver type
Important for interaction with membranes
Phosphatidylinositol 4-kinase type 2-alpha
Reduces targeting to synaptic vesicles and neurite tips; when associated with A-60.
Reduces targeting to synaptic vesicles and neurite tips; when associated with A-61.
Peptidyl-prolyl cis-trans isomerase FKBP8
Decreased binding of fragment 1-61 to BoNT/B heavy chain.
Impaired calcium-binding and phosphorylation by WNK1.
Nearly wild-type binding of fragment 1-61 to BoNT/B heavy chain.
No binding of fragment 1-61 to BoNT/B heavy chain.
Na(+)/H(+) exchange regulatory cofactor NHE-RF3
Activates the enzyme when modified in vitro
Class E basic helix-loop-helix protein 40
Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1, SUMO2 and SUMO3)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1, SUMO2 and SUMO3); alternate
Necessary for interaction with RXRA and repressor activity against RXRA
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Hypoxanthine-guanine phosphoribosyltransferase
Phosphoserine; by PAK1, PAK2, PAK3 and PAK5
RAF proto-oncogene serine/threonine-protein kinase
RNA-polymerase II-associated protein 3-like C-terminal
N-linked (GlcNAc...) asparagine; partial
Processed zona pellucida sperm-binding protein 2
Cilia- and flagella-associated protein 157
Loss of palmitoylation and targeting to postsynaptic density.
SNF-related serine/threonine-protein kinase
cAMP-dependent protein kinase inhibitor alpha
Impaired internalization after somatostatin binding.
Reduced basal and somatostatin-induced phosphorylation. Impaired internalization after somatostatin binding.
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Required for interaction with SSNA1 and microtubules
Required for interaction with microtubules and microtubule severing
Mitochondrial brown fat uncoupling protein 1
No effect on GTP-binding. Decreased fatty acid-induced proton transport.
No effect on GTP-binding. Decreased fatty acid-induced proton transport. Loss of fatty acid-induced proton transport; when associated with A-25 and A-31.
No effect on GTP-binding. Decreased fatty acid-induced proton transport; when associated with L-146.
No effect on GTP-binding. Decreased fatty acid-induced proton transport; when associated with L-148.
No effect on GTP-binding. Loss of fatty acid-induced proton transport; when associated with V-28 and A-31.
No effect on GTP-binding. No effect on fatty acid-induced proton transport. Loss of fatty acid-induced proton transport; when associated with A-25 and V-28.
Killer cell lectin-like receptor subfamily B member 1F
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Mitochondrial import inner membrane translocase subunit Tim8 A
Eukaryotic translation initiation factor 5
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Galactose-1-phosphate uridylyltransferase
Regulating synaptic membrane exocytosis protein 4
FHF complex subunit HOOK-interacting protein 1B
FHF complex subunit HOOK-interacting protein C-terminal
Interaction with cytokine/interferon/growth hormone receptors
Submandibular glandular kallikrein-9 heavy chain
Submandibular glandular kallikrein-9 light chain
Poly (ADP-ribose) glycohydrolase (PARG) catalytic
Interchain; with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B; the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin)
Sodium channel protein type 8 subunit alpha
CSC1/OSCA1-like N-terminal transmembrane
tRNA (guanine(10)-N2)-methyltransferase homolog
FXYD domain-containing ion transport regulator
FXYD domain-containing ion transport regulator 6
Chloride intracellular channel protein 5
Helical; Note=After insertion into the membrane
Required for insertion into the membrane
Trafficking protein particle complex subunit 3
Interleukin-1 receptor-associated kinase-like 2
Dual specificity mitogen-activated protein kinase kinase 1
Glycosyltransferase 6 domain-containing protein 1
Cytosolic Fe-S cluster assembly factor NUBP1
Steroidogenic acute regulatory protein, mitochondrial
Interaction with DPF motifs-containing proteins
Necessary and sufficient to mediate interaction with CANX
SH3-containing GRB2-like protein 3-interacting protein 1
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Beta-galactoside alpha-2,6-sialyltransferase 2
Translation initiation factor eIF-2B subunit delta
Nuclear receptor subfamily 4 group A member 1
Phosphoserine; by PKA, RPS6KA1 and RPS6KA3
Required for binding NBRE-containing DNA
Does not affect anion-dependent electromotility-related charge movement.
Does not affect anion-dependent electromotility-related charge movement. Abrogates salicylate inhibition of electromotility-related charge movement.
Does not affect anion-dependent electromotility-related charge movement. Strongly attenuates inhibition by oxalate of electromotility-related charge movement. Is sensible to intracellular thiol-reactive reagents. Is completely insensitive to both reagents applied to the extracellular face of the membrane. Strongly affects the interaction with oxalate.
Fully abolishes anion-dependent electromotility-related charge movement.
Is accessible from the extracellular side after extracellular application of thiol-reactive reagents.
Is only accessible to the intracellular side application of thiol-reactive reagents. Is not affected by thiol-reactive reagents extracellular side application.
Largely abolishes anion-dependent electromotility-related charge movement.
No effect; when associated with Q-218 and Q-285.
No effect; when associated with Q-281 and Q-283.
No effect; when associated with Q-283 and Q-285.
No effect; when associated with Q-557 and Q-558.
No effect; when associated with Q-557 and Q-559.
No effect; when associated with Q-558 and Q-559.
Shifts the voltage-sensitivity to more negative values.
Shifts the voltage-sensitivity to more negative values; when associated with Q-233 and Q-235.
Shifts the voltage-sensitivity to more negative values; when associated with Q-233 and Q-236.
Shifts the voltage-sensitivity to more negative values; when associated with Q-235 and Q-236.
Shifts the voltage-sensitivity to more positive values.
Shifts the voltage-sensitivity to slightly more positive values.
Shifts the voltage-sensitivity to slightly more positive values; when associated with Q-571 and Q-572.
Shifts the voltage-sensitivity to slightly more positive values; when associated with Q-571 and Q-577.
Shifts the voltage-sensitivity to slightly more positive values; when associated with Q-572 and Q-577.
Coiled-coil domain-containing protein 184
Fibroblast growth factor-binding protein 1
Sufficient for interaction with FGF2 and FGF2-induced effects
Glycosylation-dependent cell adhesion molecule 1
General transcription and DNA repair factor IIH helicase subunit XPB
Interaction with ATM, CKIP, IFP35 and NMI
Pleckstrin homology domain-containing family O member 1
N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate
Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM
Peptidase S9 prolyl oligopeptidase catalytic
Thyroid hormone receptor-associated protein 3
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Hydroxymethylglutaryl-CoA synthase, mitochondrial
Cyclic AMP-responsive element-binding protein 1
Loss of phosphorylation by CaMK2. Activation by CaMK2.
Phosphoserine; by CaMK1, CaMK2, CaMK4, PKB/AKT1 or PKB/AKT2, RPS6KA3, RPS6KA4, RPS6KA5 and SGK1
Eukaryotic glycogen debranching enzyme N-terminal
Glycogen debranching enzyme glucanotransferase
Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-644: A-933; A-1022 and A-1175.
Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-644; A-806; A-1022 and A-1175.
Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-644; A-806; A-933 and A-1022.
Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-644; A-806; A-933 and A-1175.
Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-806; A-933; A-1022 and A-1175.
Rap guanine nucleotide exchange factor 2
tRNA (cytosine(38)-C(5))-methyltransferase
Leucine-rich repeat transmembrane neuronal protein 2
Reduced heparan sulfate binding and reduced induction of presynaptic differentiation; when associated with 157-A-A-158, A-181 and A-208.
Reduced heparan sulfate binding and reduced induction of presynaptic differentiation; when associated with 157-A-A-158, A-206 and A-208.
Reduced heparan sulfate binding and reduced induction of presynaptic differentiation; when associated with 157-A-A-158; A-181 and A-206.
Reduced heparan sulfate binding and reduced induction of presynaptic differentiation; when associated with A-181, A-206 and A-208.
cAMP-dependent protein kinase type II-alpha regulatory subunit
Abolishes phosphorylation by PKA; when associated with A-446.
Abolishes phosphorylation by PKA; when associated with C-443.
In ADMS: Dominant negative mutation that abolishes channel activity; leads to myokymia, neuromyotonia, spontaneous epileptic seizures and premature death.
Is blocked by the scorpion mesomartoxin, with an IC(50)=16.60 nM.
Is not blocked by the scorpion mesomartoxin.
Potassium voltage-gated channel subfamily A member 1
Chromosome transmission fidelity protein 8 homolog
Methylcytosine dioxygenase TET1-3 oxygenase
Calcium-activated potassium channel subunit alpha-1
In isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6.
Loss of heme-induced channel inhibition as well as carbon monoxide-induced channel activation.
Pro-neuregulin-2, membrane-bound isoform
Required for DNA-binding and interaction with NFKBIA
Participates in a stacking interaction with the adenine ring of AMP
Deoxyuridine 5'-triphosphate nucleotidohydrolase
FLYWCH-type zinc finger-containing protein N-terminal
Proteasome activator complex subunit 4 C-terminal
Lipid-binding serum glycoprotein N-terminal
Non-structural maintenance of chromosomes element 1 homolog
Protein N-terminal glutamine amidohydrolase
Protein N-terminal glutamine amidohydrolase alpha beta roll
Golgi associated RAB2 interactor protein-like Rab2B-binding
11-beta-hydroxysteroid dehydrogenase type 2
Mas-related G-protein coupled receptor member H
Cleavage; by factor Xa, factor XIIa, factor IXa, or thrombin
Serine/threonine-protein kinase PRP4 homolog
NACHT, LRR and PYD domains-containing protein 3
Required for binding to phosphatidylinositol 4-phosphate (PtdIns4P)
Pro-opiomelanocortin/corticotropin ACTH central region
Catalytic domain; necessary for arylsulfatase activity
Extracellular sulfatase Sulf-2 secreted form
Hydrophilic domain; necessary for endoglucosamine-6-sulfatase activity
Golgi-associated RAB2 interactor protein 1B
Asymmetric dimethylarginine; by CARM1; alternate
Asymmetric dimethylarginine; by PRMT6; alternate
N6-(2-hydroxyisobutyryl)lysine; alternate
N6-(beta-hydroxybutyryl)lysine; alternate
Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5
Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5
Symmetric dimethylarginine; by PRMT5; alternate
3-beta hydroxysteroid dehydrogenase/isomerase
Class A basic helix-loop-helix protein 15
Cytochrome b-c1 complex subunit 6, mitochondrial
Rapamycin-insensitive companion of mTOR N-terminal
Rapamycin-insensitive companion of mTOR middle
Spindle and kinetochore-associated protein 3
Abolishes interaction with DPM1; when associated with L-21.
Abolishes interaction with DPM1; when associated with S-23.
Dolichol phosphate-mannose biosynthesis regulatory protein
Actin-related protein 2/3 complex subunit 5
NACHT, LRR and PYD domains-containing protein 6
Fanconi anemia core complex-associated protein 20
Strong reduction in secretin (SCT)-binding.
Phosphatidylcholine:ceramide cholinephosphotransferase 1
C-terminal inhibitory domain; interacts with PCSK1
Transmembrane O-methyltransferase homolog
Essential for polyglutamine aggregation suppression
Glucose-6-phosphatase catalytic subunit 1
Phosphatidic acid phosphatase type 2/haloperoxidase
Endoplasmic reticulum membrane adapter protein XK
Soluble Vascular Cell Adhesion Molecule-1
Probable E3 ubiquitin-protein ligase IRF2BPL
Leucine-rich repeat-containing protein 51
Mannose-1-phosphate guanyltransferase alpha
N6,N6-dimethyllysine; alternate; by EEF1AKMT3
N6-methyllysine; alternate; by EEF1AKMT3
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form
Cysteine/serine-rich nuclear protein N-terminal
Calcium-activated potassium channel BK alpha subunit
Loss of chloride-activated potassium channel activity. Loss of potassium selectivity. Inhibited by chloride. Expression in primary dorsal root ganglion neurons induces membrane hyperexcitability and neuronal toxicity.
Inositol polyphosphate-related phosphatase
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
Transient receptor potential cation channel subfamily V member 2
Acyl-CoA-binding domain-containing protein 5
Integrin-linked kinase-associated serine/threonine phosphatase 2C
Serine/threonine specific protein phosphatases
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Guanylate cyclase soluble subunit beta-1
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Protein arginine methyltransferase NDUFAF7, mitochondrial
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Beta-chain polymerization, binding distal domain of another fibrin
Cleavage; by thrombin; to release fibrinopeptide B
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Phosphatidate cytidylyltransferase, mitochondrial
Submandibular gland secretory Glx-rich protein CB
Ubiquitin carboxyl-terminal hydrolase 42
3 beta-hydroxysteroid dehydrogenase type 7
Regenerating islet-derived protein 3-gamma 15 kDa form
Regenerating islet-derived protein 3-gamma 16.5 kDa form
Tubulin polyglutamylase complex subunit 2
Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog
Cyclic AMP-responsive element-binding protein 3-like protein 1
Processed cyclic AMP-responsive element-binding protein 3-like protein 1
Abolishes interactions with HOMER1C and NF2.
Abolishes phospholipid binding and nuclear localization; when associated with N-679.
Abolishes phospholipid binding and nuclear localization; when associated with N-687.
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Protein phosphatase 1 regulatory subunit 15A
Protein phosphatase 1 regulatory subunit 15A/B C-terminal
Required for localization in the endoplasmic reticulum
Nuclear transcription factor Y subunit gamma
Dimethyladenosine transferase 1, mitochondrial
Ribosomal RNA adenine methylase transferase N-terminal
Amyloid-beta A4 precursor protein-binding family A member 3
Baculoviral IAP repeat-containing protein 5
Phosphothreonine; by ROCK2 and PKC/PRKCI
Abolishes interaction with CALM1. Decreases interaction with SYT4 and SYT11. Abolishes location to neuronal dense core vesicles.
Required for interaction with CALM1, PPFIA2 and TANC2
Abolishes calcium binding, lowering of binding to myotubes and some loss of AChR clustering activity; when associated with A-1831.
Abolishes calcium binding, lowering of binding to myotubes and some loss of AChR clustering activity; when associated with A-1900.
Abolishes chondroitin sulfate (CS) binding, greatly reduced branched retraction fiber (BRF) formation, filopodia formation reduced by about 50% and lowered RAC1 and CDK1 activation. No chondroitin sulfate (CS) nor heparan sulfate (HS) binding almost no retraction fiber (BRF) formation, filopodia formation reduced by about 60% lowered RAC1 and CDK1 activation; when associated with 566-AGGAGA-571.
Abolishes formation of AGRN-LRP4 complex and MUSK activation.
Abolishes formation of AGRN-LRP4 complex and MUSK activation. No AChR clustering activity.
Abolishes fucosylation of muscle agrin. Stimulates MUSK phosphorylation and increases AChR clustering.
Abolishes heparan sulfate (HS) binding, greatly reduced branched retraction fiber (BRF) formation, filopodia formation reduced by about 50% and lowered RAC1 and CDK1 activation. No chondroitin sulfate (CS) nor heparan sulfate attachment, almost no branched retraction fiber (BRF) formation, filopodia formation reduced by about 60% and lowered RAC1 and CDK1 activation; when associated with 953-AGA-955.
About 13% reduction in cleavage by neurotrypsin.
About 20% reduction in cleavage by neurotrypsin.
About 23% reduction in cleavage by neurotrypsin. Reduces cleavage by neurotrypsin by about 90%; when associated with A-1752. Completely abolishes cleavage by neurotrypsin; when associated with A-1753.
About 30% reduction in cleavage by neurotrypsin.
About 41% reduction in cleavage by neurotrypsin. Reduces cleavage by neurotrypsin by about 90%; when associated with A-1751. Completely abolishes cleavage by neurotrypsin; when associated with A-1753.
About 55% reduction in cleavage by neurotrypsin.
About 60% reduction in cleavage by neurotrypsin.
About 62% reduction in cleavage by neurotrypsin.
About 64% reduction in cleavage by neurotrypsin.
Almost completely abolishes cleavage by neurotrypsin.
Almost completely abolishes cleavage by neurotrypsin. Completely abolishes cleavage by neurotrypsin; when associated with A-1751 or A-1752.
Alternative splice site to produce 'x' isoforms
Alternative splice site to produce 'y' isoforms
Alternative splice site to produce 'z' isoforms
Completely abolishes cleavage by neurotrypsin.
Highly important for the agrin receptor complex activity of the 'z(8)' insert
No effect formation of AGRN-LRP4 complex nor on MUSK activation.
No effect on formation of AGRN-LRP4 complex nor on MUSK activation.
Significant reduction in AChR clustering ability.
Slight reduction in AChR clustering ability.
Slight reduction in AChR clustering ability. Slight reduction in AChR clustering ability.
Slight reduction in cleavage by neurotrypsin.
DNA-directed RNA polymerase I subunit RPA1
Loss of kinase activity, disruption of cleavage furrow formation, failure of cytokinesis leading to cell polyploidy death.
Ankyrin repeat and BTB/POZ domain-containing protein 2
Abolished protein-glutamine gamma-glutamyltransferase activity without affecting alpha-1 adrenergic receptor signaling.
Destabilizes the compact conformation in presence of GTP.
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)
Protein-glutamine gamma-glutamyltransferase 2
Bactericidal permeability-increasing protein
Histone-lysine N-methyltransferase KMT5B
No significant effect on interaction with RAB3IP.
Required for netrin-mediated axon repulsion of neuronal growth cones
Sprouty-related, EVH1 domain-containing protein 2
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Intraflagellar transport protein 172 homolog
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Capping protein, Arp2/3 and myosin-I linker protein 3
TATA box-binding protein-associated factor RNA polymerase I subunit D
Condensin II complex subunit H2 N-terminal
Condensin-2 complex subunit H2 C-terminal
Disintegrin and metalloproteinase domain-containing protein 5
Important for homomultimer formation and localization to presynaptic regions
Tumor protein p63-regulated gene 1-like protein
Leucine-rich repeat-containing protein 26
N6-acetyllysine; by EP300/CBP, PCAF/KAT2B and GCN5/KAT2A
N6-acetyllysine; by PCAF/KAT2B and GCN5/KAT2A
Retains proapoptotic activity. Does not heterodimerizes.
4 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-C
Inhibits ability to activate VEGFR-2 and VEGFR-3.
Histone deacetylase complex subunit SAP130 C-terminal
ATP-binding cassette sub-family D member 1
PEX19 binding site and required for peroxisomal targeting
Chromatin assembly factor 1 subunit p150 C-terminal
Chromatin assembly factor 1 subunit p150 N-terminal
Extracellular cell-membrane anchored RET cadherin 120 kDa fragment
Proto-oncogene tyrosine-protein kinase receptor Ret
Vesicle transport through interaction with t-SNAREs homolog 1A
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1
Required for interaction with TPGS1, LRRC49, and TTLL1
Pulmonary surfactant-associated protein D
Fasciculation and elongation protein zeta-2
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Leucine zipper alpha helical coiled-coil region
Phosphoserine; by ATM and ATR and dsDNA kinase
Transcription intermediary factor 1-beta
Cyclic AMP-dependent transcription factor ATF-2
Essential for its histone acetyltransferase activity
Phosphoserine; by PKC/PRKCA and PKC/PRKCB
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Chromodomain-helicase-DNA-binding protein 8
Induces a decrease in sumoylation status.
Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central
Proton donor; shared with dimeric partner
Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediates
Cancer-associated gene 1 protein homolog
G-protein coupled receptors family 2 profile 2
Necessary for interaction with Ran and nuclear export complex formation
Solute carrier organic anion transporter family member 3A1
Transient receptor potential cation channel subfamily M member 8
receptor protein serine/threonine kinase
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
Actin, gamma-enteric smooth muscle, intermediate form
Ankyrin repeat domain-containing protein 46
O-linked (Xyl...) (chondroitin sulfate) serine
Ubiquitin-activating enzyme E1 four-helix bundle
Sodium-coupled neutral amino acid symporter 1
Probable ATP-dependent RNA helicase DDX52
Chloride intracellular channel protein 6
Mediates interaction with ESR1 and STUB1
ATP synthase subunit beta, mitochondrial
Necessary for its localzation to the endoplasmic reticulum and lipid droplets
Cleavage; by caspase-3, caspase-7 and caspase-8
Serine/threonine-protein kinase 24 12 kDa subunit
Serine/threonine-protein kinase 24 35 kDa subunit
Serine/threonine-protein phosphatase 2A regulatory subunit B" subunit gamma
ADP-ribosylation factor-like protein 13A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
Coiled-coil domain-containing protein 43
Tumor necrosis factor receptor superfamily member 1B
Decreases synaptic insertion during chemical-induced long term potentiation.
Ionotropic glutamate receptor C-terminal
Ionotropic glutamate receptor L-glutamate and glycine-binding
Phosphoserine; by PKC, PKA and PKG/PRKG2
Tubulin-specific chaperone cofactor E-like protein
Tyrosine-protein phosphatase non-receptor type 2
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Increases KM for ornithine 5-fold and decreases kcat 20-fold.
Ornithine transcarbamylase, mitochondrial
Strong decrease in ornithine carbamoyltransferase activity.
Mothers against decapentaplegic homolog 7
WD repeat domain phosphoinositide-interacting protein 4
Long-chain-fatty-acid--CoA ligase ACSBG1
Rho family-interacting cell polarization regulator 2
Cell division cycle-associated 7-like protein
Histone-lysine N-methyltransferase SETMAR
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Approximately 5-fold decrease in Vmax for (R,S)-mevalonate. Approximately 3-fold increase in KM for (R,S)-mevalonate.
Induce significant secondary structural change.
Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-91, A-166 and A-336.
Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-91, A-96 and A-166.
Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-91, A-96 and A-336.
Abolishes agonist-induced G-protein-independent receptor internalization; when associated with A-96, A-166 and A-336.
Abolishes basal phosphorylation; when associated with A-363. Abolishes basal and agonist-induced phosphorylation; when associated with A-363 and A-375. Accelerates agonist-induced receptor internalization.
Abolishes basal phosphorylation; when associated with A-370. Abolishes basal and agonist-induced phosphorylation; when associated with A-370 and A-375. Accelerates agonist-induced receptor internalization.
Constitutive active. Some constitutive activity; when associated with E-275.
Decrease in phosphorylation, no decrease in G-protein binding.
Impairs ARRB2- and GRK3-mediated receptor desensitization.
Impairs agonist affinity and increases agonist-induced inhibition of adenylate cyclase.
Impairs agonist affinity, agonist-induced inhibition of adenylate cyclase and coupling to G-proteins.
Impairs phosphorylation and abolishes agonist-mediated acute receptor desensitization.
NPxxY; plays a role in stabilizing the activated conformation of the receptor
No change in palmitoylation. No change in palmitoylation; when associated with A-351.
No change in palmitoylation; when associated with A-346.
No effect on constitutive activation. Impairs agonist affinity and agonist-induced inhibition of adenylate cyclase.
No effect on constitutive activation. Some constitutive activity; when associated with K-279.
No effect on inhibition of adenylate cyclase.
Reduces agonist-induced receptor internalization. Abolishes morphine-induced phosphorylation. Restores agonist-specific PRKCE activity. Abolishes basal and agonist-induced phosphorylation; when associated with A-363 and A-370.
Interaction with O-glycosylated substrate glycoprotein
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
Necessary for binding to the m3G-cap structure
Necessary for interaction with KPNB1 and m3G-cap U1 and U5 snRNP import receptor activity
11 X 12 AA approximate repeats of an acidic serine cluster
Nucleolar and coiled-body phosphoprotein 1
Probable proton-coupled zinc antiporter SLC30A3
Transient receptor potential cation channel subfamily M member 1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
ATP-binding cassette sub-family F member 3
Guanine nucleotide exchange factor for Rab-3A
Mitochondrial import inner membrane translocase subunit Tim8 B
Mediates cell survival and induction of the IAP family of survival proteins
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Abolishes conversion from the dehydrogenase form to the oxidase form; when associated with A-535 and R-992.
Converts the enzyme to the oxidase form that utilizes molecular oxygen as electron acceptor. Interferes with normal conversion to the dehydrogenase form by reducing agents.
Slows the conversion from the dehydrogenase form to the oxidase form; when associated with A-535. Abolishes conversion from the dehydrogenase form to the oxidase form; when associated with A-535 and S-1316.
Slows the conversion from the dehydrogenase form to the oxidase form; when associated with R-992. Abolishes conversion from the dehydrogenase form to the oxidase form; when associated with R-992 and S-1316.
Abolishes catalytic activity. Decreases substrate binding affinity.
Abolishes catalytic activity. No effect on substrate binding.
Greatly decreased activation by polyphosphate anions, and deficient in activation by small peptides; when associated with A-898 and A-899.
Greatly decreased activation by polyphosphate anions, and deficient in activation by small peptides; when associated with A-898 and A-901.
Greatly decreased activation by polyphosphate anions, and deficient in activation by small peptides; when associated with A-899 and A-901.
Greatly decreased activation by polyphosphate anions.
Strongly reduced catalytic activity. Abolishes stimulation of activity by ATP.
Strongly reduced catalytic activity. Strongly reduced stimulation of activity by ATP.
Specifically androgen-regulated gene protein
Katanin p60 ATPase-containing subunit A-like 1
N-end rule aminoacyl transferase C-terminal
Abolishes inhibition of neurite outgrowth from CNS neurons.
No effect on inhibition of neurite outgrowth from sensory neurons.
Required for normal axon myelination in the central nervous system
Involved in Ca(2+)-dependent inactivation
Transient receptor potential cation channel subfamily V member 5
WAP four-disulfide core domain protein 1
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D
No effect on transcriptional activation of CSF1R or FCER1A promoter.
contacts bases in the GGAA sequence in the major groove
contacts the phosphate backbone of the GGAA sequence in the minor groove upstream
forms a salt bridge with the phosphate backbone of the opposite strand downstream of the GGAA core sequence
Potassium voltage-gated channel subfamily E member 3
Processed zona pellucida sperm-binding protein 1
Aldehyde dehydrogenase family 3 member A2
ATP-binding cassette sub-family C member 6
Does not affect plasma membrane localization. Abolishes cellular ATP release.
FIGNL1-interacting regulator of recombination and mitosis
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
SURP and G-patch domain-containing protein 1
Gamma-aminobutyric acid receptor subunit pi
RNA polymerase II elongation factor ELL3
Echinoderm microtubule-associated protein-like 1
No in vitro cleavage by caspase-3; when associated with E-591. Results in loss of JNK activation; when associated with E-591.
No in vitro cleavage by caspase-3; when associated with E-594. Results in loss of JNK activation; when associated with E-594.
Serine/threonine-protein kinase receptor
Methionine-R-sulfoxide reductase B2, mitochondrial
Ankyrin repeat domain-containing protein 61
Abolishes tyrosine phosphorylation and PTPN11 binding; when associated with F-436; F-477 and F-501.
Abolishes tyrosine phosphorylation and PTPN11 binding; when associated with F-460; F-477 and F-501.
Strongly reduces insulin-induced tyrosine phosphorylation and PTPN11 binding. Abolishes tyrosine phosphorylation and PTPN11 binding; when associated with F-436; F-460 and F-477.
Strongly reduces insulin-induced tyrosine phosphorylation and PTPN11 binding. Abolishes tyrosine phosphorylation and PTPN11 binding; when associated with F-436; F-460 and F-501.
Tyrosine-protein phosphatase non-receptor type substrate 1
Reduces phosphorylation and inhibits DNA-binding and transcriptional activation.
Hydrophobic; mediates interaction with membranes
Required for degradation in response to high membrane cholesterol levels
Strongly decreased affinity for squalene.
Zinc finger CCCH domain-containing protein 18
Sodium-dependent multivitamin transporter
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
ATP synthase F(0) complex subunit B1, mitochondrial
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
Eukaryotic translation initiation factor 2D
No effect on interaction with BTRC and FBXW11. Strongly decreases interaction with BTRC and FBXW11 and increases protein stability; when associated with 478-N--N-482.
Strongly decreases interaction with BTRC and FBXW11 and increases protein stability. Strongly decreases interaction with BTRC and FBXW11 and increases protein stability; when associated with 93-I--I-97.
N-linked (GlcNAc...) (complex) asparagine
Glutamate receptor ionotropic, kainate 5
PxLPxI/L motif; mediates interaction with ANKRA2
Mitochondrial sodium/calcium exchanger protein
In isoform 2, isoform 4, isoform 6 and isoform 8.
In isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8.
In isoform 5, isoform 6, isoform 7 and isoform 8.
Inositol 1,4,5-trisphosphate receptor type 1
Required for interaction with RPP20/POP7
Exocyst complex component Sec3 PIP2-binding N-terminal
Mediates the interaction with RAB13 and intramolecular interaction with the calponin-homology (CH) domain
Necessary and sufficient to associate with tubular recycling endosome membranes, mediate phosphatidic acid-binding and membrane tubulation
DMimics phosphorylation, leading to inhibit the ability of TSC2 to suppress mTORC1 signaling; when associated with D-939.
Decreased phosphorylation by PKB/AKT1; when associated with A-1130--1132-A and A-1422.
Decreased phosphorylation by PKB/AKT1; when associated with A-939 and A-1130--1132-A.
Decreased phosphorylation by PKB/AKT1; when associated with A-939 and A-1422.
Mimics phosphorylation, leading to inhibit the ability of TSC2 to suppress mTORC1 signaling; when associated with D-1130--1132-E.
Cilia- and flagella-associated protein 298
Killer cell lectin-like receptor subfamily I member 2
D-2-hydroxyglutarate dehydrogenase, mitochondrial
Receptor-interacting serine/threonine-protein kinase 3
Homeodomain-interacting protein kinase 4
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Interaction with RAD52, TIPIN, UNG and XPA
Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate
Schiff-base intermediate with dihydroxyacetone-P
Covalently modified during suicide inhibition by leukotrienes
Essential for epoxide hydrolase activity, but not for aminopeptidase activity
Cytochrome c oxidase subunit 7A2, mitochondrial
Regulating synaptic membrane exocytosis protein 1
Isoglutamyl cysteine thioester (Cys-Gln)
Interaction with RSN and localization to the Golgi and kinetochores
Interaction with microtubules, MAPRE1 and MAPRE3
SXIP motif 1; mediates interaction with MAPRE1 and targeting to microtubule plus ends
SXIP motif 2; mediates interaction with MAPRE1 and targeting to microtubule plus ends
Cyclic nucleotide-gated cation channel alpha-4
Natural cytotoxicity triggering receptor 1
Motile sperm domain-containing protein 1
Vimentin-type intermediate filament-associated coiled-coil protein
Inhibitory (P1) (chymotrypsin, elastase)
Inter-alpha-trypsin inhibitor light chain
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)
Interferon-induced, double-stranded RNA-activated protein kinase
Calcium/calmodulin-dependent protein kinase kinase 1
Decrease in phosphorylation and partial inhibition by PKA. Almost loss of inhibition by PKA; when associated with A-108.
Decrease in phosphorylation and partial inhibition by PKA. Almost loss of inhibition by PKA; when associated with A-458.
Loss of substrate recognition and interaction with CAMK4.
Insulin-like growth factor-binding protein 4
Loss of activity. Loss of MAPK14 phosphorylation and of PCDH8 internalization.
Guanine nucleotide-binding protein G(i) subunit alpha-2
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; K-92; G-96; A-98; A-99; A-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; G-96; A-98; A-99; A-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; A-98; A-99; A-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-98; A-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-98; A-99; A-111; G-112 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with G-111; G-112 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-98; A-99; A-111; G-112 and T-121. Does not increase sensitivity to RGS14 GTPase activity; when associated with G-111; G-112 and T-121.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-98; A-99; A-111; G-112; T-121 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with G-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-98; A-99; A-111; T-121 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with G-111; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-98; A-99; G-112; T-121 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with G-112; T-121 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with I-82 and A-85.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-86; R-90; K-92; G-96; A-99; A-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; I-85; R-90; K-92; G-96; A-98; A-99; A-111; G-112; T-121 and A-122.
Increases sensitivity to RGS14 GTPase activity; when associated with I-82; R-86; R-90; K-92; G-96; A-98; A-99; A-111; G-112; T-121 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with I-82 and A-111.
Increases sensitivity to RGS14 GTPase activity; when associated with I-85; R-86; R-90; K-92; G-96; A-98; A-99; A-111; G-112; T-121 and A-122. Does not increase sensitivity to RGS14 GTPase activity; when associated with I-85 and A-111.
May mediate active transcriptional repression
Abolishes activation of serine/threonine-protein kinase activity and only basal activity remains.
Loss of activity; neither activated by TAOK1 nor by STK11/LKB1.
Loss of phosphorylation by CaMK1, decrease in kinase activity and ability to promote neurite outgrowth; when associated with 91-A--A-93.
Loss of phosphorylation by CaMK1, decrease in kinase activity and ability to promote neurite outgrowth; when associated with A-294.
Phosphomimetic mutant that leads to activation but not in presence of GSK3-beta.
Stress-associated endoplasmic reticulum protein 1
Abolishes palmitoylation but not membrane-association; when associates with A-30. No effect on glutamate decarboxylase activity; when associated with A-30.
Abolishes palmitoylation but not membrane-association; when associates with A-45. No effect on glutamate decarboxylase activity; when associated with A-45.
No effect on glutamate decarboxylase activity.
Histone-binding protein RBBP4 N-terminal
Coiled-coil domain-containing protein 116
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
ATF7-interacting protein protein binding
Methionyl-tRNA formyltransferase, mitochondrial
Potassium voltage-gated channel subfamily S member 3
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
Does not affect neither deacetylase nor sulfotransferase activities.
Does not affect sulfotransferase activity but abolishes deacetylase activity.
Does not affect sulfotransferase activity but increases deacetylase activity.
Does not affect sulfotransferase activity but strongly decreases deacetylase activity.
Does not affect sulfotransferase activity but weakly affects deacetylase activity.
Induces a reduction in sulfotransferase activity but does not affect deacetylase activity.
Induces a reduction in sulfotransferase activity but increases deacetylase activity.
Loss of deacetylase and sulfotransferase activities.
Loss of sulfotransferase activity but does not affect deacetylase activity.
Sufficient for localization to Golgi membrane
Important for acidic pH-dependent nucleoside transporter activity. Acts as pH sensor
Biorientation of chromosomes in cell division protein 1
No effect on heterodimerization with 14-3-3 proteins.
No heterodimerization with 14-3-3 proteins. No effect on heterodimerization with BCL2 nor with protein P11.
Phosphoserine; by PKA, PKB, PAK1, RPS6KA1, RPS6KB1 and PKC/PRKCQ
4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)
Ankyrin repeat domain-containing protein 16
Required to capture Ser that is misactivated by AARS/AlaRS
Programmed cell death protein 2 C-terminal
Loss of autophosphorylation and activity.
Loss of autophosphorylation and activity. Loss of autophosphorylation and activity; when associated with A-176.
Loss of autophosphorylation and activity. Loss of autophosphorylation and activity; when associated with F-178.
Necessary to interact with ESRRA, to regulate its subcellular localization and to inhibit its transcriptional activity
PXXXP motif; regulates binding with chromatin and interaction with PCNA
Requires for interaction with GABARAP, MAP1LC3B AND GABARAPL1
ATP-dependent 6-phosphofructokinase, muscle type
Mitochondrial amidoxime reducing component 2
Mediates interaction with REV1 and REV3L and homodimerization
Mitotic spindle assembly checkpoint protein MAD2B
Peroxisomal multifunctional enzyme type 2
VPS35 endosomal protein-sorting factor-like
10-fold more potently inhibited by the alpha-conotoxin RgIA.
Abolishes dependency on RIC3 for functional expression.
Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane
Impairs dependency on RIC3 for functional expression.
Neuronal acetylcholine receptor subunit alpha-7
No change in inhibition by the alpha-conotoxin RgIA.
No effect on dependency on RIC3 for functional expression.
Slightly impairs dependency on RIC3 for functional expression.
30% decrease of nitric-oxide synthase activity.
50% decrease of nitric-oxide synthase activity.
No decrease in nitric-oxide synthase activity.
Platelet-activating factor acetylhydrolase IB subunit alpha2
Dehydrogenase/reductase SDR family member 9
Critical for TLR4-TLR6 dimerization and signaling
Sister chromatid cohesion protein PDS5 homolog A
DNA-directed DNA polymerase family A palm
Breast carcinoma-amplified sequence 1 homolog
In isoform 3, isoform 4, isoform 5 and isoform 6.
External hydrophobic patch (EHP); regulates polymerization into filaments
Flexible ZP-N/ZP-C linker; important for secretion and polymerization into filaments
Interchain (between heavy and light chains)
Hydroxymethylglutaryl-CoA lyase, mitochondrial
Uncharacterized protein C1orf105 homolog
Little elongation complex subunit 2 C-terminal
Phosphoserine; by IKKB, MAPK8 and RPS6KB1
Low affinity immunoglobulin gamma Fc region receptor III
Transmembrane and ubiquitin-like domain-containing protein 2
Mapk-regulated corepressor-interacting protein 1
Cilia- and flagella-associated protein 61 N-terminal
Potassium voltage-gated channel subfamily A member 5
Sodium channel modifier 1 acidic C-terminal
Omega-N-methylarginine; by CARM1; alternate
Impaired light-induced proteasomal degradation.
Important for the catalytic mechanism; involved in substrate deprotonation
No effect on light-induced proteasomal degradation.
No effect on light-induced proteasomal degradation; when associated with R-8, R-99 and R-168.
No effect on light-induced proteasomal degradation; when associated with R-99, R-133 and R-168.
No effect on proteasomal degradation; when associated with R-8, R-99 and R-133.
No effect onlight-induced proteasomal degradation; when associated with R-8, R-133 and R-168.
von Willebrand factor A domain-containing protein 3A
Pericentriolar material 1 protein C-terminal
>1000-fold increase of sensitivity to the conotoxin GVIIJ(SSG).
Cys residue near the selectivity filter, which has a free thiol that is susceptible to reaction with methanethiosulfonate (MTSET); Sodium current is irreversibly blocked by MTSET
Little change in voltage-dependence of conductance and decrease in affinity to the sea anemone toxin anthopleurin-B (residue Lys-37).
Sodium channel protein type 5 subunit alpha
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Fibroblast growth factor receptor substrate 3
Interaction with HSPA5 and localization to the endoplasmic reticulum
Gamma-aminobutyric acid receptor subunit alpha-3
O-linked (Gal...) hydroxylysine; alternate
Glucocorticoid modulatory element-binding protein 1
Loss of localization to the late endosomes and redistribution to the cytoplasm.
N-acetylmethionine; in RNA binding motif protein, X-linked-like-1; alternate
N-acetylvaline; in RNA binding motif protein, X-linked-like-1, N-terminally processed
RNA-binding motif protein, X chromosome retrogene-like
RNA-binding motif protein, X chromosome retrogene-like, N-terminally processed
Loss of GABA and glycine transport activity. Loss of potential gradient-induced Cl(-) uptake. Loss of beta-alanine transport activity.
Retains around 80% of the beta-alanine transport activity.
Vesicular inhibitory amino acid transporter
Guanine nucleotide-binding protein G(o) subunit alpha
LETM1 domain-containing protein LETM2, mitochondrial
Endothelial PAS domain-containing protein 1
Required for heterodimer formation with ARNT
Centrosomal protein of 290kDa coiled-coil region
Potassium voltage-gated channel subfamily H member 5
Dephospho-CoA kinase domain-containing protein
Coiled-coil domain-containing protein 33
Spliceosome-associated protein CWC27 homolog
DNA-directed RNA polymerase II subunit GRINL1A
Mothers against decapentaplegic homolog 1
Phosphothreonine; by MINK1, TNIK and MAP4K4
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Helical; Signal-anchor for type III membrane protein
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Coiled-coil domain-containing protein 127
Abolished phosphorylation by CK2 and increased activation of NF-kappa-B; when associated with A-526; A-528 and A-531.
Abolished phosphorylation by CK2 and increased activation of NF-kappa-B; when associated with A-526; A-528 and A-533.
Abolished phosphorylation by CK2 and increased activation of NF-kappa-B; when associated with A-526; A-531 and A-533.
Abolished phosphorylation by CK2 and increased activation of NF-kappa-B; when associated with A-528; A-531 and A-533.
Caspase recruitment domain-containing protein 9
Mediates interaction with the PDZ domain of NOS1
Vacuolar protein 14 C-terminal Fig4-binding
Lysosome-associated membrane glycoprotein 5
Calcium/calmodulin-dependent protein kinase II inhibitor 1
Reduces at least 100-fold the inhibitory potency; when associated with 59-K--A-61.
Reduces at least 100-fold the inhibitory potency; when associated with P-43.
Adrenocortical dysplasia protein homolog
Leucine-rich repeat-containing protein 59
Leucine-rich repeat-containing protein 59, N-terminally processed
N-acetylthreonine; in Leucine-rich repeat-containing protein 59, N-terminally processed
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Aminoacyl-transfer RNA synthetases class-II family profile
Aflatoxin B1 aldehyde reductase member 3
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
Methionine adenosyltransferase 2 subunit beta
Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Mediates proton transfer from the protein to the inner aqueous phase
Abolishes interaction with phosphorylated INSR.
Abolishes phosphorylation in response to insulin.
Reduces interaction with phosphorylated INSR.
Dephenylalaninated tubulin alpha-8 chain
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Mini-chromosome maintenance complex-binding protein
Cytoplasmic dynein 2 light intermediate chain 1
In isoform 2, isoform 4, isoform 6, isoform 8, isoform 10 and isoform 12.
In isoform 3, isoform 4, isoform 9 and isoform 10.
In isoform 5, isoform 6, isoform 11 and isoform 12.
In isoform 7, isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12.
cGMP-dependent 3',5'-cyclic phosphodiesterase
Dipeptidyl peptidase 4 60 kDa soluble form
Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal
Changes active site geometry and alters affinity for NAD.
S-adenosyl-L-homocysteine hydrolase NAD binding
Strongly reduces S-adenosyl-L-homocysteine hydrolase activity.
Abolishes protein phosphatase 1 binding.
Interaction with ADRA2A, ADRA2B and ADRA2C
Loss of phosphorylation by PKA. No effect on localization to synapse. Inhibits the spontaneous release of neurotransmitters.
Bifunctional peptidase and arginyl-hydroxylase JMJD5
Tricarboxylate transport protein, mitochondrial
Small ribosomal subunit protein mS23 conserved
Gamma-aminobutyric acid receptor subunit alpha-4
G protein-coupled receptor associated sorting protein 3
KN motif and ankyrin repeat domain-containing protein 2
Cysteinyl-selenocysteine (Cys-Sec); redox-active
With bound glutathione and undetermined modification.
Without bound glutathione or undetermined modification.
LYR motif 1; required for interaction with HSC20
LYR motif 2; not required for interaction with HSC20
Succinate dehydrogenase assembly factor 1, mitochondrial
Oligosaccharyltransferase complex subunit OSTC
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
C-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signal
Double-stranded RNA-specific adenosine deaminase
N-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signal
Dual specificity testis-specific protein kinase 2
Interaction with 5' end of substrate DNA
N-linked (GlcNAc...) (high mannose) asparagine; alternate
N-linked (GlcNAc...) (hybrid) asparagine; alternate
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
DNA (cytosine-5)-methyltransferase 3-like
Translocon-associated protein subunit beta
Gamma-aminobutyric acid receptor subunit beta-3
26S proteasome non-ATPase regulatory subunit 13
C4-type zinc-finger of DNA polymerase delta
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
N-acetyltransferase ESCO acetyl-transferase
Important for interaction with adenosine receptors and increasing their affinity for agonists
Phospho-regulated basic and hydrophobic (PRBH) motif
Decreased phosphorylation by WNK kinases, leading to increased potassium-chloride cotransport activity; when associated with A-1030.
Decreased phosphorylation by WNK kinases, leading to increased potassium-chloride cotransport activity; when associated with A-929.
Mimics phosphorylation, leading to increased potassium-chloride cotransport activity; when associated with E-1030.
Mimics phosphorylation, leading to increased potassium-chloride cotransport activity; when associated with E-929.
Ectonucleoside triphosphate diphosphohydrolase 5
In isoform D, isoform E, isoform F and isoform H.
Potassium channel voltage dependent KCNQ C-terminal
Potassium voltage-gated channel subfamily KQT member 2
Phosphotyrosine; by autocatalysis, CSK and MATK
tRNA-splicing endonuclease subunit Sen54 N-terminal
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
Interaction with phosphoinositide-3 kinase
Sodium/potassium-transporting ATPase subunit alpha-2
Mesoderm-specific transcript homolog protein
Confers cellular localization similar to full-length form
7 X 7 AA tandem repeats of Q-G-P-Y-[AP]-G-P
Loss of inhibition of KCNH2 channel stimulation.
Slightly reduces activation by arachidonic acid.
Methyl-CpG binding protein 2/3 C-terminal
SH3 domain-containing YSC84-like protein 1
Beta-crystallin B3, N-terminally processed
N-acetylalanine; in Beta-crystallin B3, N-terminally processed
Crucial for 5-methylcytosine recognition
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Interaction with phosphotyrosine-containing peptide
Protein kinase C delta type catalytic subunit
Protein kinase C delta type regulatory subunit
Aldehyde dehydrogenase family 16 member A1
Aspartate aminotransferase, mitochondrial
Exclusive nuclear localization. Shows a reduction in synaptic contacts and dendritic processes.
Extranuclear localization and reduced CABP1 and KPNA1 binding. Shows a reduction in synaptic contacts and dendritic processes.
NMDA receptor synaptonuclear signaling and neuronal migration factor
Necessary and sufficient to elicit dendritic processes and synaptic contacts
Loss of p53/TP53-deubiquitinating activity.
Impairs synaptic transmission. Abolishes the chloride ion conductance.
Loss of L-glutamate release. Abolishes the chloride ion conductance.
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
Interferon-induced transmembrane protein 3
Geranylgeranyl transferase type-2 subunit alpha
Rab geranylgeranyltransferase alpha subunit insert-domain
PHD finger-like domain-containing protein 5A
Apically localized. Loss of PRKCA-dependent cell motility.
Globular or compact configuration stabilized by disulfide bonds
Localized to the lamellipodia. Increases cell motility independently of PRKCA activation.
No chondroitin sulfate attachment. Loss of localization to the retraction fibers.
No effect on chondroitin sulfate attachment.
Dynein heavy chain ATP-binding dynein motor region
Dynein heavy chain hydrolytic ATP-binding dynein motor region
Neuromedin U precursor-related peptide 33.
Neuromedin U precursor-related peptide 36, oxidized.
Neuromedin U precursor-related peptide 36.
Probable ribosome biogenesis protein RLP24
May be involved in recognition of long-chain fatty acids in GPI
Phosphatidylinositol glycan anchor biosynthesis class U protein
Required for dimerization upon membrane association
Dehydrogenase/reductase SDR family member 7B
D-beta-hydroxybutyrate dehydrogenase, mitochondrial
Mitochondrial import inner membrane translocase subunit Tim17-A
RNA/RNP complex-1-interacting phosphatase
Brefeldin A-inhibited guanine nucleotide-exchange protein 2
DCB; DCB:DCB domain and DCB:HUS domain interaction
SPRY domain-containing SOCS box protein 2
HIG1 domain family member 1A, mitochondrial
Alpha galactosidase A C-terminal beta-sandwich
Peroxidase-like; mediates peroxidase activity
Lipid-binding serum glycoprotein C-terminal
Zinc finger CCCH domain-containing protein 14
Consistently high basal adenylate cyclase activity; when associated with A-1196. Does not affect calmodulin binding; when associated with A-1196.
Consistently high basal adenylate cyclase activity; when associated with A-1200. Does not affect calmodulin binding; when associated with A-1200.
Decraeses significantly the stimulatoty effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.
Does not affect adenylate cyclase activity in response to calcium in vitro. Reduces adenylate cyclase activity in response to capacitative calcium entry (CCE). Reduces colocalization with actin. Does not improve the distribution of the actin cytoskeleton at the plasma membrane.
Does not affect calcium activated adenylate cyclase.
Does not affect calcium activated adenylate cyclase. Does not affect calmodulin binding.
Does not affect calcium activated adenylate cyclase. Increases slightly basal adenylate cyclase activity but not significantly, and retains an appreciable calcium regulation. Significant high basal adenylate cyclase activity; when associated with N-1197.
Does not affect calcium activated adenylate cyclase. Significant high basal adenylate cyclase activity. Significant high basal adenylate cyclase activity; when associated with Q-1202.
Does not affect calcium activated adenylate cyclase; when associated with A-1197 and A-1198. Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51; 38-A--A-40; A-1197 and A-1198. Has an elevated basal activity; when associated with A-1197 and A-1198. Does not affect calmodulin binding; when associated with A-1197 and A-1198.
Does not affect calcium activated adenylate cyclase; when associated with A-1197. Does not affect calcium activated adenylate cyclase; when associated with A-1197 and A-1202. Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51; 38-A--A-40; A-1197 and A-1202. Has an elevated basal activity; when associated with A-1197. Has an elevated basal activity; when associated with A-1197 and A-1202. Does not affect calmodulin binding; when associated with A-1197. Does not affect calmodulin binding; when associated with A-1197 and A-1202.
Does not affect calcium activated adenylate cyclase; when associated with A-1198. Does not affect calcium activated adenylate cyclase; when associated with A-1198 and A-1202.Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51; 38-A--A-40; A-1198 and A-1202. Has an elevated basal activity; when associated with A-1198. Has an elevated basal activity; when associated with A-1198 and A-1202. Does not affect calmodulin binding; when associated with A-1198. Does not affect calmodulin binding; when associated with A-1198 and A-1202.
Does not affect calcium activated adenylate cyclase; when associated with E-1202. Greatly diminishes calmodulin binding; when associated with E-1202.
Does not affect calcium activated adenylate cyclase; when associated with E-1204. Greatly diminishes calmodulin binding; when associated with E-1204.
Does not affect calcium activated adenylate cyclase; when associated with E-1208. Does not affect calmodulin binding; when associated with E-1208.
Does not affect calcium activated adenylate cyclase; when associated with E-1209. Does not affect calmodulin binding; when associated with E-1209.
Does not affect deglycosylation. Does not affect plasma membrane targeting; when associated with Q-814 and A-818. Affects membrane raft localization; when associated with Q-814 and A-818. Does not affect CCE-stimulated adenylate cyclase activity; when associated with Q-814 and A-818.
Does not affect deglycosylation. Does not affect plasma membrane targeting; when associated with Q-814 and A-885. Affects membrane raft localization; when associated with Q-814 and A-885. Does not affect CCE-stimulated adenylate cyclase activity; when associated with Q-814 and A-885.
Does not affect deglycosylation. Does not affect plasma membrane targeting; when associated with Q-818 and A-885. Affects membrane raft localization; when associated with Q-818 and A-885. Does not affect CCE-stimulated adenylate cyclase activity; when associated with Q-818 and A-885.
Does not affect dimerization. Does not affect dimerization;when associated with A-432. Does not affect dimerization;when associated with A-446 and A-432. Does not affect dimerization;when associated with A-432; A-446 and A-453. Dramatically reduces the levels of the N-glycosylated monomeric species. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-432.Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-446 and A-432. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-453; A-432 and A-446. Loss of calcium- and calmodulin-responsive adenylate cyclase activity. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-432. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-446 and A-432. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-453; A-432 and A-446. Affects membrane raft localization. Affects membrane raft localization; when associated with A-432. Affects membrane raft localization; when associated with A-446 and A-432. Affects membrane raft localization; when associated with A-439; A-432 and A-446.
Does not affect dimerization; when associated with A-439 and A-432. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-439 and A-432. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-439 and A-432. Affects membrane raft localization; when associated with A-439 and A-432.
Does not affect dimerization; when associated with A-439. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-439. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-439. Affects membrane raft localization; when associated with A-439.
Does not affect dimerization; when associated with A-439; A-432 and A-446. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-439; A-432 and A-446. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-439; A-432 and A-446. Affects membrane raft localization; when associated with A-439; A-432 and A-446.
Does not affect the stimulatoty effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.
Does not affect the stimulatoty effect of PKA inhibitoron calcium-stimulated adenylate cyclase activity.
Does not interact with CALM1; when associated with 38-A--A-40. Interacts with PPP2CA; when associated with 38-A--A-40. Greatly reduces CCE-stimulated adenylate cyclase activity; when associated with 38-A--A-40. Does not affect caveolar localization; when associated with 38-A--A-40.Does not affect calcium/calmodulin stimulated adenylate cyclase activity; when associated with 38-A--A-40. Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 38-A--A-40; A-1197; A-1198 and A-1202.
Does not interact with CALM1; when associated with 49-A--A-51. Interacts with PPP2CA; when associated with 49-A--A-51. Greatly reduces CCE-stimulated adenylate cyclase activity; when associated with 49-A--A-51. Does not affect caveolar localization; when associated with 49-A--A-51. Does not affect calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51. Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51; A-1197; A-1198 and A-1202.
Essential for autoinhibition maintenance
Essential for autoinhibition maintenance by promoting interaction of the N and C termini
Increased CCE-stimulated adenylate cyclase activity. Has a high basal activity.
Insensitive to the stimulatory effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.
Involved in AKAP5 and PRKAR2A interaction
Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction
Loses adenylate cyclase activity in response to calcium.
Loses the stimulatoty effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.
Required for both calcium stimulation and maintenance of autoinhibition
Gamma-butyrobetaine hydroxylase-like N-terminal
Trimethyllysine dioxygenase, mitochondrial
Neurogenic locus notch homolog protein 3
Dehydrogenase/reductase SDR family member 4
Important for the maintenance of the quaternary structure, the catalytic activity and cold stability
Responsible for the stereoselective reduction of 3-ketosteroids into 3alpha-hydroxysteroids and benzil into S-benzoin
Chymotrypsin-like elastase family member 1
Growth hormone secretagogue receptor type 1
Activated RNA polymerase II transcriptional coactivator p15
Transcriptional coactivator p15 (PC4) C-terminal
Regenerating islet-derived protein 3-beta 15 kDa form
Regenerating islet-derived protein 3-beta 16.5 kDa form
D-box that targets the protein for proteasomal degradation in anaphase
Important for interaction with phosphorylated proteins
Vacuolar protein sorting-associated protein 26A
Signaling threshold-regulating transmembrane adapter 1
Leucine zipper putative tumor suppressor 2
Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severing
Cleavage; by procollagen C-endopeptidase
Cleavage; by procollagen N-endopeptidase
Transcription factor CBF/NF-Y/archaeal histone
Mas-related G-protein coupled receptor member A
Mitochondrion outer membrane (MOM)-targeting sequence
N-terminal EF-hand calcium-binding protein 2
FXYD domain-containing ion transport regulator 5
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Activation by thioester intermediate formation with UBA6
Neuronal PAS domain-containing protein 4
9 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-P
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
ATP-binding cassette sub-family G member 5
Cilia- and flagella-associated protein 119
ATP-sensitive inward rectifier potassium channel 11
Inward rectifier potassium channel C-terminal
Potassium channel inwardly rectifying transmembrane
Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium
Conserved oligomeric Golgi complex subunit 4
(Microbial infection) Cleavage; by C.botulinum neurotoxin type B (BoNT/B, botB)
(Microbial infection) Cleavage; by C.botulinum neurotoxin type D (BoNT/D, botD)
(Microbial infection) Cleavage; by C.botulinum neurotoxin type F (BoNT/F, botF)
(Microbial infection) Cleavage; by C.botulinum neurotoxin type G (BoNT/G, botG)
(Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)
(Microbial infection) Cleavage; by C.tetani tetanus toxin (tetX)
Cystic fibrosis transmembrane conductance regulator
Post-GPI attachment to proteins factor 4
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Large ribosomal subunit protein uL15/eL18
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1
Increases nucleophilicity of active site Cys
Necessary for interaction with APP and inhibitor effects on APP processing
Methylated-DNA--protein-cysteine methyltransferase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Disintegrin and metalloproteinase domain-containing protein 1
Bombesin receptor-activated protein C6orf89 homolog
Almost complete loss of binding to GNAO1. No inhibition of GTPase activity.
Little oxidized neuronal proteins. Scarce amyloid-beta protein 42 aggregation. No neurotoxicity.
No chondroitin sulfate linkage to isoform L-APP733.
No effect on neurite growth and maturation.
O-linked (Xyl...) (chondroitin sulfate) serine; in L-APP isoforms
Required for the interaction with KIF5B and for anterograde transport in axons
YENPXY motif; contains endocytosis signal
Influences on amino acid transport capacity
Sodium-coupled neutral amino acid transporter 4
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
BAG family molecular chaperone regulator 1
Solute carrier organic anion transporter family member 1A4
Intraflagellar transport protein 80 homolog
5'-AMP-activated protein kinase subunit gamma-1
Cytochrome c oxidase subunit 7B, mitochondrial
cGMP-dependent protein kinase interacting
Polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type
WD repeat domain phosphoinositide-interacting protein 2
High affinity immunoglobulin epsilon receptor subunit alpha
5 X 7 AA approximate tandem repeats of D-R-[NS]-H-E-K-S
Abolishes interaction with DLG1, DLG4 and HOMER1.
Eukaryotic translation initiation factor 3 subunit E
Nuclear factor interleukin-3-regulated protein
Target of rapamycin complex subunit LST8
RNA polymerase II assembly factor Rtp1 C-terminal
Glutamate receptor-interacting protein 1
Processed sterol regulatory element-binding protein 1
Sterol regulatory element-binding protein 1
Coiled-coil domain-containing protein 89
ADP-ribosylation factor-like protein 6-interacting protein 4
Constitively active mutant. Does not affect interaction with APBB1/FE65.
Dexamethasone-induced Ras-related protein 1
Glycerol-3-phosphate acyltransferase 2, mitochondrial
Ubiquitin carboxyl-terminal hydrolase MINDY-1
NAD(P)(+)--arginine ADP-ribosyltransferase
In TFM; has only 10-15% of the androgen-binding capacity of wild-type AR.
Interaction with coactivator FXXLF and FXXFY motifs
Interaction with coactivator LXXL and FXXFY motifs
G-protein coupled receptors family 2 profile 1
In isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7.
Trafficking protein particle complex subunit 1
Probable ATP-dependent RNA helicase DDX4
Domain of unknown function with conserved HDNR motif
DALR anticodon-binding domain-containing protein 3
Glycerophosphocholine phosphodiesterase GPCPD1
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Probable phospholipid-transporting ATPase IIB
Potassium voltage-gated channel subfamily H member 4
Important for degradation of atrial natriuretic peptide by IDE
Choline affinity is increased fourfold by MMTS; when associated with A-155; A-179; S-322; A-358; A-418; S-437; A-470 and A-474.
Choline affinity is increased fourfold by MMTS; when associated with A-26; A-155; A-179; S-322; A-358; A-418; A-437 and A-470.
Choline affinity is increased fourfold by MMTS; when associated with A-26; A-155; A-179; S-322; A-358; A-418; A-437 and A-474.
Choline affinity is increased fourfold by MMTS; when associated with A-26; A-155; A-179; S-322; A-358; A-418; A-470 and A-474.
Choline affinity is increased fourfold by MMTS; when associated with A-26; A-155; A-179; S-322; A-358; S-437; A-470 and A-474.
Choline affinity is increased fourfold by MMTS; when associated with A-26; A-155; A-179; S-322; A-418; S-437; A-470 and A-474.
Choline affinity is increased fourfold by MMTS; when associated with A-26; A-155; S-322; A-358; A-418; S-437; A-470 and A-474.
Choline affinity is increased fourfold by MMTS; when associated with A-26; A-179; S-322; A-358; A-418; S-437; A-470 and A-474.
Decreased MPP(+) uptake, no change in MPP(+) affinity. Decreased NMN uptake, increased NMN affinity. Decreased choline uptake, increased choline affinity.
Decreased TEA uptake. No change in MPP(+) uptake.
Decreased guanidine, histamine, serotonin and TEA uptake. No change in MPP(+) uptake. Increased TEA and MPP(+) affinity. Decreased TEA and MPP(+) Vmax.
Decreased guanidine, histamine, serotonin and TEA uptake. No change in MPP(+) uptake. No change in TEA and MPP(+) affinity. Decreased TEAVmax. No change in MPP(+) Vmax.
Decreased guanidine, histamine, serotonin, TEA and MPP(+) uptake. Decreased TEA affinity. No change in MPP(+) affinity. Decreased TEA and MPP(+) Vmax.
Decreased guanidine, serotonin, TEA and MPP(+) uptake. No change in histamine uptake. Increased TEA and MPP(+) affinity. Decreased TEA and MPP(+) Vmax.
No change in guanidine, histamine, serotonin, TEA and MPP(+) uptake. Increased TEA affinity. No change in MPP(+) affinity. Decreased TEAVmax. No change in MPP(+) Vmax.
No effect of PKC-induced stimulation on ASP uptake. No effect of PKC-induced stimulation on ASP uptake; when associated with A-286; A-292; A-296 and A-550. No effect of PKA activation on ASP uptake. No effect of PKA activation on ASP uptake; when associated with A-286; A-292; A-296 and A-550. Significant reduction of ASP uptake by p56(lck) tyrosine kinase-induced inhibition. Significant reduction of ASP uptake by p56(lck) tyrosine kinase-induced inhibition; when associated with A-286; A-292; A-296; A-550. No significant effect on trafficking from intracellular pools to the cell membrane; when associated with A-286; A-292; A-296 and A-550. suppresses phosphorylation by PKC; when associated with A-286; A-292; A-296 and A-550.
No effect of PKC-induced stimulation on ASP uptake. No effect of PKC-induced stimulation on ASP uptake; when associated with A-286; A-292; A-296; A-328. Significant increase of the ASP uptake by PKA activation. No effect of PKA activation on ASP uptake; when associated with A-286; A-292; A-296 and A-328. Significant reduction of ASP uptake by p56(lck) tyrosine kinase-induced inhibition. Significant reduction of ASP uptake by p56(lck) tyrosine kinase-induced inhibition; when associated with A-286; A-292; A-296; A-328. No significant effect on trafficking from intracellular pools to the cell membrane; when associated with A-286; A-292; A-296 and A-328. suppresses phosphorylation by PKC; when associated with A-286; A-292; A-296 and A-328.
No effect of PKC-induced stimulation on ASP uptake. No effect of PKC-induced stimulation on ASP uptake; when associated with A-286; A-292; A-328; A-550. Significant increase of the ASP uptake by PKA activation. No effect of PKA activation on ASP uptake; when associated with A-286; A-292; A-328; A-550. Significant reduction of ASP uptake by p56(lck) tyrosine kinase-induced inhibition. Significant reduction of ASP uptake by p56(lck) tyrosine kinase-induced inhibition; when associated with A-286; A-292; A-328; A-550. No significant effect on trafficking from intracellular pools to the cell membrane; when associated with A-286; A-292; A-328 and A-550. suppresses phosphorylation by PKC; when associated with A-286; A-292; A-328 and A-550.
No effect of PKC-induced stimulation on ASP uptake. No effect of PKC-induced stimulation on ASP uptake; when associated with A-286; A-296; A-328 and A-550. No effect of PKA activation on ASP uptake. No effect of PKA activation on ASP uptake; when associated with A-286; A-296; A-328 and A-550. Significant reduction of ASP uptake by p56(lck) tyrosine kinase-induced inhibition. Significant reduction of ASP uptake by p56(lck) tyrosine kinase-induced inhibition; when associated with A-286; A-296; A-328 and A-550. No significant effect on trafficking from intracellular pools to the cell membrane; when associated with A-286; A-296; A-328 and A-550. suppresses phosphorylation by PKC; when associated with A-286; A-296; A-328 and A-550.
No effect of PKC-induced stimulation on ASP uptake. No effect of PKC-induced stimulation on ASP uptake; when associated with A-292; A-296; A-328 and A-550. No effect of PKA activation on ASP uptake. No effect of PKA activation on ASP uptake; when associated with A-292; A-296; A-328 and A-550. Significant reduction of ASP uptake by p56(lck) tyrosine kinase-induced inhibition. Significant reduction of ASP uptake by p56(lck) tyrosine kinase-induced inhibition; when associated with A-292; A-296; A-328 and A-550. No significant effect on trafficking from intracellular pools to the cell membrane; when associated with A-292; A-296; A-328 and A-550. suppresses phosphorylation by PKC; when associated with A-292; A-296; A-328 and A-550.
Reduces the activation by MMTS. Abolishes the activation by MMTs; when associated with M-451. Choline affinity is increased fivefold by MMTS. Choline affinity is increased fourfold by MMTS; when associated with A-26; A-155; A-179; A-358; A-418; S-437; A-470 and A-474. Choline affinity is increased four- to fivefold; when associated with M-451.
Reduces the activation by MMTS. Abolishes the activation by MMTs; when associated with S-322. Abolishes the effect of MMTs on choline-induced currents. Choline affinity is not influenced by MMTS. Choline affinity is increased four- to fivefold; when associated with S-322.
Large ribosomal subunit protein uL6 N-terminal
Necessary for interaction with TCEA1 and transactivation activity
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
ATPsynthase alpha/beta subunit N-terminal extension
Lamina-associated polypeptide 2, isoform beta
Interaction with phosphoserine on interacting protein
Insulin-like growth factor-binding protein 1
Leucine-rich repeat-containing protein 18
N-acetylthreonine; in GTPase KRas, N-terminally processed
Sorting and assembly machinery component 50 homolog
Putative glutathione-specific gamma-glutamylcyclotransferase 2
Mitochondrial cytochrome c oxidase subunit VIc/VIIs
Phenazine biosynthesis-like domain-containing protein
Mitogen-activated protein kinase kinase kinase 12
Beta-1,3-N-acetylglucosaminyltransferase radical fringe
Important for interaction with ARHGAP26 AND ARHGAP10
Important for increased permeability to Na(+) when K(+) levels are subphysiological
Important for intracellular retention in recycling endosomes
Part of a hydrophobic barrier that is stochastically dewetted and limits ion permeability
Loss of mitochondrial fission-stimulating activity; when associated with A-77; A-84; A-91 and A-97.
Loss of mitochondrial fission-stimulating activity; when associated with A-77; A-84; A-91 and A-98.
Loss of mitochondrial fission-stimulating activity; when associated with A-77; A-84; A-97 and A-98.
Loss of mitochondrial fission-stimulating activity; when associated with A-77; A-91; A-97 and A-98.
Loss of mitochondrial fission-stimulating activity; when associated with A-84; A-91; A-97 and A-98.
Biogenesis of lysosome-related organelles complex 1 subunit 1
Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substrates
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Glucosamine/galactosamine-6-phosphate isomerase
Plasminogen activator inhibitor 2 type A
17-fold increase in affinity for oxytocin. No change in affinity for arginine vasopressin or 1-deamino, D-Arg8-vasopressin.
50-fold decrease in affinity for arginine vasopressin. Little affect on affinity for oxytocin or 1-deamino, D-Arg8-vasopressin.
No significant change in affinity for arginine vasopressin or oxytocin. Increased affinity for 1-deamino, D-Arg8-vasopressin.
Reduced palmitoylation, coupling to G protein unaffected. Abolished isoprenylation, coupling to G protein unaffected; when associated with G-371.
Reduced palmitoylation, coupling to G protein unaffected. Abolished isoprenylation, coupling to G protein unaffected; when associated with G-372.
Glycosyl hydrolase family 30 beta sandwich
Oncoprotein-induced transcript 3 protein
Guided entry of tail-anchored proteins factor CAMLG
Polypeptide N-acetylgalactosaminyltransferase 5
Cyclic AMP-dependent transcription factor ATF-6 alpha
Processed cyclic AMP-dependent transcription factor ATF-6 alpha
Disintegrin and metalloproteinase domain-containing protein 7
Complement C1r subcomponent-like protein
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Leucine-rich repeat and fibronectin type III domain-containing protein 1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein
Mesencephalic astrocyte-derived neurotrophic factor
Starch-binding domain-containing protein 1
Necessary for interaction with RAB11A and function in neurite outgrowth
Sufficient for localization to endoplasmic reticulum tubular network and for interactions with REEP1, REEP5, ATL1, ATL2, ATL3 and SPAST
Intramolecular interaction with C-terminus
Intramolecular interaction with N-terminus
Polypeptide N-acetylgalactosaminyltransferase 11
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Does not affect alanine transport activity.
Does not affect amino acid transport activity. Significantly decreases alanine transport activity.
Does not affect cell membrane localization.
Does not affect cell membrane localization. Eliminates the sodium-induced anion leak current. Inhibits amino acid transport activity. Reduces affinity for sodium ion.
Does not affect the alanine-induced transport current. Reduces the amino acid affinity.
Impairs amino acid transport. Impairs the interaction of SNAT2 with the cotransported sodium ion.
Impairs transport current. Reduces the amino acid affinity.
Loss of amino acid transport activity. Loss of amino acid uptake activity. Reduces the amino acid affinity.
Modifies the transporter pH-sensitivity.
Partially loss of glycosylation. Completely loss of glycosylation; when associated with Q-258 and Q-272. Decreases expression; when associated with Q-258 and Q-272. Does not affect cell membrane localization; when associated with Q-258 and Q-272.
Partially loss of glycosylation. Dramatically loss of glycosylation; when associated with Q-258. Completely loss of glycosylation; when associated with Q-254 and Q-258. Decreases expression; when associated with Q-258. Decreases expression; when associated with Q-254 and Q-258. Does not affect cell membrane localization; when associated with Q-258. Does not affect cell membrane localization; when associated with Q-254 and Q-258.
Partially loss of glycosylation. Dramatically loss of glycosylation; when associated with Q-272. Completely loss of glycosylation; when associated with Q-254 and Q-272. Decreases expression; when associated with Q-272. Decreases expression; when associated with Q-254 and Q-272. Does not affect cell membrane localization; when associated with Q-272. Does not affect cell membrane localization; when associated with Q-254 and Q-272.
Reduces amino acid transport activity of 75%. Significantly decreases alanine transport activity.
Regulates protein turnover upon amino acid deprivation
Significantly decreases alanine transport activity.
Sodium-coupled neutral amino acid symporter 2
2'-5'-oligoadenylate synthase-like protein 2
Important for C5-methylcytosine-recognition
Geranylgeranyl transferase type-1 subunit beta
Probable ATP-dependent RNA helicase DDX59
Impaired interaction with GRIP1 and GRIP2.
Amyloid-beta A4 precursor protein-binding family A member 1
Enhanced APP binding and amyloid-beta production.
Nuclear receptor subfamily 0 group B member 1
NADPH:adrenodoxin oxidoreductase, mitochondrial
Nucleolus and neural progenitor protein-like N-terminal
Required for interaction with EZR, MSN and RDX and for co-localization to microvilli
Transcription elongation factor A protein-like 1
Small nuclear ribonucleoprotein-associated protein N
Cell surface glycoprotein CD200 receptor 1
Abolishes peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity.
Copper type II ascorbate-dependent monooxygenase C-terminal
Copper type II ascorbate-dependent monooxygenase N-terminal
In isoform PAM-2, isoform PAM-3, isoform PAM-3A and isoform PAM-3B.
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase
Peptidylglycine alpha-amidating monooxygenase
Peptidylglycine alpha-hydroxylating monooxygenase
Reduces peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity.
Trafficking protein particle complex subunit 2B
Prokaryotic-type class I peptide chain release factors
Cilia- and flagella-associated protein 97
Steroid 17-alpha-hydroxylase/17,20 lyase
Dynein assembly factor with WD repeat domains 1
TATA box-binding protein-associated factor RNA polymerase I subunit B
Abolishes clustered subcellular distribution in neurons.
Abolishes clustered subcellular distribution in neurons. Does not affect KCNB1-containing vesicles motility.
Does not reduce apoptotic enhancement of potassium current during the cell death program.
Loss of SUMO-dependent channel activity modulation in hippocampal neurons.
No effect on Src-mediated phosphorylation.
No loss of SUMO-dependent channel activity modulation in hippocampal neurons.
Phosphoserine; by CDK5, MAPK14; in vitro
Potassium voltage-gated channel subfamily B member 1
Reduces channel activity. Does not inhibit membrane plasma subcellular localization, interaction with STX1A, pore-independent exocytosis activity and apoptotic enhancement of potassium current during cell death program; when associated with C-369.
Reduces channel activity. Does not inhibit membrane plasma subcellular localization, interaction with STX1A, pore-independent exocytosis activity and apoptotic enhancement of potassium current during cell death program; when associated with T-384.
Reduces the increase of plasma membrane insertion and apoptotic enhancement of potassium current during cell death program. No change in calcineurin-dependent regulation of voltage-dependent gating. Abolishes the increase of plasma membrane insertion and apoptotic enhancement of potassium current during cell death program; when associated with F-128.
Reduces the increase of plasma membrane insertion and apoptotic enhancement of potassium current during cell death program. Significant loss of Src-mediated phosphorylation and channel activity. Reduces interaction with PTPRE. Increases cell viability against apoptotic insults. Abolishes the increase of plasma membrane insertion and apoptotic enhancement of potassium current during cell death program; when associated with D-804.
Resists voltage-dependent gating on calcineurin-dependent activation and steady-state inactivation.
Shift in voltage-dependent gating on calcineurin-dependent activation and steady-state inactivation.
Shift in voltage-dependent gating on calcineurin-dependent activation and steady-state inactivation. Additive effect on activation and steady-state inactivation; when associated with A-15.
Shift in voltage-dependent gating on calcineurin-dependent activation and steady-state inactivation. Additive effect on activation and steady-state inactivation; when associated with A-457.
Shift in voltage-dependent gating on calcineurin-dependent activation and steady-state inactivation. Larger effect on activation and steady-state inactivation; when associated with A-567.
Shift in voltage-dependent gating on calcineurin-dependent activation and steady-state inactivation. Larger effect on activation and steady-state inactivation; when associated with A-607.
Xylosyl- and glucuronyltransferase LARGE2
Glutaminase kidney isoform, mitochondrial 65 kDa chain
Glutaminase kidney isoform, mitochondrial 68 kDa chain
Calcium release-activated calcium channel protein 1
Important for ABL1-mediated Tyr-718 phosphorylation
O-linked (Xyl...) (glycosaminoglycan) serine
Transforming growth factor beta receptor type 3
Binds predominantly to PtdIns(P5) and weaker to PtdIns(P3) abd PtdIns(P4); involved in neurite outgrowth regulation
Mitochondrial potassium channel ATP-binding subunit
Dimethyladenosine transferase 2, mitochondrial
HA-stretch; determines single-channel conductance in 5-HT3 receptors
Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel
Mediator of RNA polymerase II transcription subunit 24
SH3 domain-binding glutamic acid-rich-like protein 3
Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Receptor-binding cancer antigen expressed on SiSo cells
Helix-hairpin-helix DNA-binding motif class 1
Misincorporates T nucleotide opposite G/C template.
Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Necessary for tumor-suppressive function
Interaction with APS and STAT5, and activation
SUN domain-containing ossification factor
Zinc-regulated GTPase metalloprotein activator 1
EF-hand calcium-binding domain-containing protein 11
TATA box binding protein associated factor (TAF) histone-like fold
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
Fine-tunes the proton-transfer properties of H-64
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Growth hormone-releasing hormone receptor
Deleted in malignant brain tumors 1 protein
Proton acceptor; for azaheterocycle hydroxylase activity
PxLPxI/L motif; mediates interaction with ANKRA2 and 14-3-3 proteins
Necessary for RNA-binding, interaction with MAGOH and localization in nucleus speckles
Necessary for localization in cytoplasmic stress granules
Ribitol-5-phosphate transferase FKTN N-terminal
Scm-like with four MBT domains protein 1
Mitochondrial outer membrane protein SLC25A46
Phosphothreonine; by MLCK and ZIPK/DAPK3
5-aminolevulinate synthase, non-specific, mitochondrial
Antiparallel alpha-helical coiled coil region
CBF1-interacting co-repressor CIR N-terminal
Ig-like V-type 1; required for binding to polymeric IgA and IgM
Chromatin target of PRMT1 protein C-terminal
Loss of inhibition of clathrin-mediated and bulk endocytosis.
Restores Ca(2+)-binding and Ca(2+)-dependent phospholipid binding.
Elongation of very long chain fatty acids protein 7
Loss of glycine transport. Retained in the endoplasmic reticulum due to defective processing and trafficking to the cell surface.
Sodium- and chloride-dependent glycine transporter 2
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
Mitogen-activated protein kinase kinase kinase 11
Phosphoserine; by autocatalysis and MAP4K1
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
ATP-binding cassette sub-family C member 12
Gly-Pro-Asn (GPN)-loop; involved in dimer interface
Stabilizes the phosphate intermediate; shared with dimeric partner
30-fold decrease in affinity for prolactin recognition element.
Odontogenic ameloblast-associated protein
Required for interaction with YY1, SIN3A and HDAC1, and transcriptional repression activity
N6,N6,N6-trimethyllysine; by METTL21A; alternate
Heparan sulfate glucosamine 3-O-sulfotransferase 1
In isoform 10, isoform 12, isoform 14, isoform 16, isoform 17 and isoform 19.
In isoform 9, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14, isoform 15, isoform 16, isoform 18 and isoform 19.
O-linked (Xyl...) (heparan sulfate) serine
Keratin, type II cytoskeletal 2 epidermal
Essential for GTPase activation (GAP) activity
Large ribosomal subunit protein uL30 N-terminal eukaryotes
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Non-canonical purine NTP phosphatase/PRRC1
Constitutive activation causing cell death.
Constitutive activation causing cell death. Activated at lower pH; when associated with A-72.
Constitutive activation causing cell death. Inactive; when associated with F-443.
Inactive. Active at lower pH; when associated with V-430.
Loss of function. Inactive; when associated with F-430.
No effect on pH dependence and function.
Reduces N-glycosylation. Abolishes N-glycosylation; when associated with S-365.
Reduces N-glycosylation. Abolishes N-glycosylation; when associated with S-392.
CCR4-NOT transcription complex subunit 9
General receptor for phosphoinositides 1-associated scaffold protein
tRNA N(3)-methylcytidine methyltransferase METTL6
Transmembrane emp24 domain-containing protein 1
ATP-binding cassette sub-family G member 8
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
Interaction with cyclic nucleotide-binding pocket
Potassium voltage-gated channel subfamily H member 1
Required for phosphatidylinositol bisphosphate binding
N-acetylvaline; in SUMO-activating enzyme subunit 1, N-terminally processed
SUMO-activating enzyme subunit 1, N-terminally processed
Reduces interaction with HSP70; impairs interaction with HSP90.
Required for MYLIP-triggered down-regulation of LDLR
Mediates interaction with sodium channels
Cyclic AMP-dependent transcription factor ATF-3
Trimeric intracellular cation channel type B
Interferon-stimulated 20 kDa exonuclease-like 2
1-acyl-sn-glycerol-3-phosphate acyltransferase delta
Regulating synaptic membrane exocytosis protein 3
Abolishes phosphorylation by EGFR. Reduces interaction with SHC1. Completely inhibits insulin-stimulated phosphorylation. No effect on INSR internalization and INS degradation. In L-SACC1; completely inhibits insulin-stimulated phosphorylation; develops hyperinsulinemia resulting from impaired insulin clearance; the hyperinsulinemia causes secondary insulin resistance with impaired glucose tolerance and random, but not fasting, hyperglycemia; insulin doesn't significantly decrease FASN activity in liver. Prevents CEACAM1 phosphorylation and the increase in its binding to FASN in the presence of INSR. No effect on cell-surface expression in response to INS.
Carcinoembryonic antigen-related cell adhesion molecule 1
Essential for interaction with PTPN11 and PTPN6
Increases INSR internalization and INS degradation. Phosphorylated by INSR. Prevents the increase in CEACAM1 binding to FASN by INSR. Decreases cell-surface expression in response to INS. Doesn't affect phosphorylation by INSR.
N-linked (GlcNAc...) asparagine; atypical
Phosphorylated on serine. Decreases bile acid transport Doesn't phosphorylated by EGFR. Doesn't increase interaction with SHC1. Completely inhibits insulin-stimulated phosphorylation. No effect on INSR internalization and INS degradation. Prevents CEACAM1 phosphorylation and the increase in its binding to FASN in the presence of INSR. No effect on cell-surface expression in response to INS. Abolishes phosphorylation by INSR. Abolishes indirect interaction with INSR.
Phosphorylated on tyrosine. Impairs bile acid transport.
Phosphotyrosine; by SRC, LCK, INSR and EGFR
Preserves the ability of INSR to induce CEACAM1 phosphorylation.
Required for interaction with PTPN11 and PTPN6 and for control of phosphorylation level
Beta-hexosaminidase eukaryotic type N-terminal
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
In isoform 4, isoform 5, isoform 6 and isoform 8.
Sodium- and chloride-dependent GABA transporter 1
Epithelial splicing regulatory protein 2
Ornithine aminotransferase, mitochondrial
Cationic amino acid transporter C-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
Protein phosphatase 1 regulatory subunit 14B
Ubiquitin-associated domain-containing protein 1
Cysteine sulfenic acid (-SOH) intermediate
In strain: LEW/NHsd, ACI/SegHsd, DA/Bkl and F344/NHsd.
In strain: LEW/NHsd, ACI/SegHsd, DA/Bkl, F344/NHsd and BN/SsNHsd.
Tumor necrosis factor receptor superfamily member 1A
Mitochondrial import inner membrane translocase subunit Tim10 B
Volume-regulated anion channel subunit LRRC8A
Cell growth regulator with RING finger domain protein 1
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
In allele Aldh2*2 and allele Aldh2*3; in strains UChA and UChB.
Abolished inhibitory effect of IFN-gamma on JNK1 activity.
Rho guanine nucleotide exchange factor 6
Required for interaction with and ubiquitination by MARCHF2
Promotes sensitivity to myricetin inhibitor.
reversibly protonated residue during proton transport
Sphingolipid delta4-desaturase N-terminal
UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Necessary for transcriptional transactivation
Mitochondrial disaggregase, cleaved form
Regulatory; slows ATPase and disaggregase activities
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Kinetochore assembly subunit CENP-C N-terminal
Abolishes lipid binding; when associated with L-63.
Strongly reduces lipid binding. Abolishes lipid binding; when associated with L-73.
Necessary and sufficient for interaction with PCP4
Mediator complex subunit Med25 synapsin 1
Mediator of RNA polymerase II transcription subunit 25 von Willebrand factor type A
Translation initiation factor eIF-2B subunit epsilon
Urokinase plasminogen activator surface receptor
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
Zinc finger FYVE domain-containing protein 21
Anaphase-promoting complex subunit CDC26
m-AAA protease-interacting protein 1, mitochondrial
Essential for specifying alpha-elongation versus initiation step of the polyglutamylase activity
May be protonated during monocarboxylate transport
Nuclear receptor-binding factor 2 C-terminal
Interaction with ubiquitin. Crossover loop which restricts access of large ubiquitin adducts to the active site
Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site
Ubiquitin carboxyl-terminal hydrolase isozyme L3
U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein
Phospholipid phosphatase-related protein type 1
CB1 cannabinoid receptor-interacting protein 1
Probable proton-coupled zinc antiporter SLC30A4
Mimicks the GTP-bound state and is enriched in the Golgi region.
Omega-N-methylarginine; by PRMT6; alternate
With 1 acetyl, 1 methyl and 2 phosphate groups.
With 1 acetyl, 1 methyl and 3 phosphate groups.
26S proteasome non-ATPase regulatory subunit 1
Leucine zipper putative tumor suppressor 3
Sufficient for mitochondrial localization
Necessary for interaction with CYFIP1, CYFIP2, FXR1 and FXR2
Helical; Voltage-sensor; Name=S4 of repeat I
Helical; Voltage-sensor; Name=S4 of repeat II
Helical; Voltage-sensor; Name=S4 of repeat III
Helical; Voltage-sensor; Name=S4 of repeat IV
Sodium channel protein type 11 subunit alpha
Signal peptidase complex catalytic subunit SEC11C
Sodium/potassium-transporting ATPase subunit alpha-3
Cytoplasmic dynein 1 intermediate chain 1
Lowers pKa of C-terminal Cys of first active site
Lowers pKa of C-terminal Cys of second active site
Important for oligomerization and fiber formation
Brain-enriched guanylate kinase-associated protein
Trafficking kinesin-binding protein C-terminal
Critical for interaction with target DNA
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Platelet-derived growth factor receptor alpha
Schiff-base intermediate with substrate; via topaquinone
Brain-specific angiogenesis inhibitor 1-associated protein 2
Loss of phosphorylation; when associated with F-115 and F-178.
Loss of phosphorylation; when associated with F-17 and F-115.
Loss of phosphorylation; when associated with F-17 and F-178.
Spindle and kinetochore-associated protein 1
Abolishes phosphatidylinisitol binding, no translocation to the cell membrane, and no effect on phosphorylation of AKT1 nor IRS1.
Decreased TRAK1 O-glycosylation by this protein.
Decreased ability to reduce neuronal mitochondrial motility in both anterograde and retrograde directions.
Loss of glycosylation activity. Loss of ability to reduce mitochondrial motility.
No effect on phosphatidylinisitol binding.
Required for phosphatidylinositol 3,4,5-triphosphate binding
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Wild-type O-GlcNAc transferase activity, does not form trimers.
Wild-type O-GlcNAc transferase activity, forms trimers.
In isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14 and isoform 15.
In isoform 2, isoform 3, isoform 5, isoform 7, isoform 8, isoform 13 and isoform 14.
In isoform 4, isoform 6, isoform 10, isoform 11, isoform 12 and isoform 15.
Solute carrier organic anion transporter family member 1A3
Myo-inositol-1-phosphate synthase GAPDH-like
Eukaryotic translation initiation factor 6
5'-AMP-activated protein kinase catalytic subunit alpha-1
Allosterically activated by AMP but is not protected against dephosphorylation by AMP or ADP.
Signal transducer and activator of transcription 5B
Hyaluronan and proteoglycan link protein 1
Vacuolar protein sorting-associated protein 4A
Serine/threonine-protein phosphatase with EF-hands 1
Endothelial differentiation-related factor 1
Cleavage; by caspase-3, caspase-6 or caspase-7
PH-like; mediates interaction with TGFB1I1
Lung adenoma susceptibility protein 2 homolog
Essential for chloroform and halothane sensitivity
Adaptin ear-binding coat-associated protein 2
Interaction with GSK3B and acts as GSK3B inhibitor
Required for GSK3B interaction; contributes to a protective effect against H(2)O(2)-induced apoptosis
Required for PRKAR2A interaction; contributes to a protective effect against H(2)O(2)-induced apoptosis
Sufficient for interaction with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200
Coiled-coil domain-containing protein 81
Multiple inositol polyphosphate phosphatase 1
7-methylguanosine phosphate-specific 5'-nucleotidase
Guided entry of tail-anchored proteins factor 1
Mitochondrial import receptor subunit TOM40 homolog
Sodium- and chloride-dependent GABA transporter 2
N-acetylthreonine; in N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed
N-terminal Xaa-Pro-Lys N-methyltransferase 1
N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed
Calcium/calmodulin-dependent protein kinase II inhibitor 2
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
Active breakpoint cluster region-related protein
Significantly reduced interaction with INCA1; when associated with A-117.
Significantly reduced interaction with INCA1; when associated with A-119.
Inhibits insulin-induced activation of endogenous Akt1, insulin-stimulated protein synthesis, insulin-induced activation of glycogen synthase and insulin-induced phosphorylation of 4E-BP1 in a dominant negative manner when overexpressed; when associated with A-308.
Inhibits insulin-induced activation of endogenous Akt1, insulin-stimulated protein synthesis, insulin-induced activation of glycogen synthase and insulin-induced phosphorylation of 4E-BP1 in a dominant negative manner when overexpressed; when associated with A-473.
Lacks kinase activity. Inhibits insulin-induced activation of glycogen synthase when expressed.
Phosphoserine; by IKKE, MTOR and TBK1; alternate
Phosphothreonine; by IKKE, PDPK1 and TBK1
RAC-alpha serine/threonine-protein kinase
Does not inhibit F-actin retrograde flow at the peripheral region of growth cones; when associated with D-101.
Does not inhibit F-actin retrograde flow at the peripheral region of growth cones; when associated with D-249.
Inhibits F-actin retrograde flow at the peripheral region of growth cones; when associated with A-101.
Inhibits F-actin retrograde flow at the peripheral region of growth cones; when associated with A-249.
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
Strongly decreases dienoyl-CoA and trienoyl-CoA isomerase activity.
Ribosome biogenesis protein BRX1 homolog
Neurogenic locus notch homolog protein 1
O-linked (GalNAc...) threonine; alternate
Ubiquinol-cytochrome-c reductase complex assembly factor 3
Complement C1q tumor necrosis factor-related protein 1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
SLIT-ROBO Rho GTPase-activating protein 2
LYR motif; required for interaction with HSC20
Probable cytosolic iron-sulfur protein assembly protein CIAO1
Abolishes homooligomerization; when associated with A-67.
No effect on interaction with PRKCI. Abolishes homooligomerization; when associated with A-67.
Interacts with DUSP and ubiquitin-like 1 domains and is required for USP4 activation
Necessary for interaction with RB1 and RBL2
Required for USP4 activation by providing conformational flexibility between the DUSP and catalytic domains
Leukocyte immunoglobulin-like receptor subfamily B member 3A
Leukocyte immunoglobulin-like receptor subfamily B member 3B
9 X 9 AA tandem repeats of Y-P-G-X(3)-P-[GS]-[AG]
Transmembrane protein 131-like N-terminal
Transmembrane protein 131-like conserved
DNA-directed RNA polymerase I subunit RPA12
Isopentenyl-diphosphate Delta-isomerase 1
Nuclear transcription factor Y subunit alpha
Probable inactive ribonuclease-like protein 13
Breast cancer anti-estrogen resistance protein 3 homolog
Mediates the interaction with BCAR1/p130CAS
Myb/SANT-like DNA-binding domain-containing protein 4
Microtubule-associated tyrosine carboxypeptidase
Alanyl-transfer RNA synthetases family profile
Small glutamine-rich tetratricopeptide repeat-containing protein beta
POU domain, class 2, transcription factor 1
Major facilitator superfamily domain-containing protein 3
3-phosphoinositide-dependent protein kinase 1
Dual serine/threonine and tyrosine protein kinase
Protein tyrosine phosphatase receptor type C-associated protein
Synaptonemal complex central element protein 1
Endoplasmic reticulum resident protein 29
Endoplasmic reticulum resident protein 29 C-terminal
T-cell leukemia translocation-altered gene protein homolog
Electron transfer via tryptophanyl radical
Voltage-gated purine nucleotide uniporter SLC17A9
Lysosome-associated membrane glycoprotein 1
Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
Gamma-aminobutyric acid type B receptor subunit 1
In isoform 1A, isoform 1B and isoform 1D.
In isoform 1B, isoform 1C and isoform 1D.
5 X 8 AA tandem repeats of P-H-G-G-G-W-G-Q
Myeloid-associated differentiation marker
Post-GPI attachment to proteins factor 2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
Interaction with galactose moiety of substrate glycoprotein
Abolished serine/threonine-protein kinase activity.
STE20/SPS1-related proline-alanine-rich protein kinase
Transitional endoplasmic reticulum ATPase
Phosphatidylethanolamine N-methyltransferase
G protein-regulated inducer of neurite outgrowth C-terminal
Proheparin-binding EGF-like growth factor
Uridine diphosphate glucose pyrophosphatase NUDT22
Does not abolish channel activity inhibition in presence of nitric oxide (NO); when associated with A-564. Absence of channel activity inhibition in presence of cAMP; when associated with A-563.
Does not abolish channel activity inhibition in presence of nitric oxide (NO); when associated with A-564. Absence of channel activity inhibition in presence of cAMP; when associated with A-564.
Potassium voltage-gated channel subfamily C member 2
Activity-dependent neuroprotector homeobox protein
Calcium-activated potassium channel subunit beta-4
Receptor-type tyrosine-protein phosphatase F
Voltage-dependent anion-selective channel protein 3
Strongly decreased affinity for acetylcholine.
Necessary for transcriptional repression
Meiosis regulator and mRNA stability factor 1
Barrier-to-autointegration factor, N-terminally processed
N-acetylthreonine; in Barrier-to-autointegration factor, N-terminally processed
Constitutively active. Constitutively interacts and stimulates PLCE1 phospholipase activity. Reduced interaction and stimulation of PLCE1; when associated with G-37 and N-38. No interaction and stimulation of PLCE1; when associated with S-35 and C-40. Interacts and partially stimulates PLCE1; when associated with G-26. Interacts but does not stimulate PLCE1; when associated with S-186.
Interacts and partially stimulates PLCE1; when associated with L-61.
Interacts but does not stimulate PLCE1; when associated with L-61.
N-acetylthreonine; in GTPase HRas, N-terminally processed
No interaction and stimulation of PLCE1; when associated with L-61.
Reduced interaction and stimulation of PLCE1; when associated with L-61.
S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine; alternate
Ribosome maturation protein SDO1/SBDS C-terminal
Ribosome maturation protein SDO1/SBDS N-terminal
Ribosome maturation protein SDO1/SBDS central
Chloride intracellular channel protein 1
Aryl hydrocarbon receptor nuclear translocator
Mediates the transcription activity and dimerization of the AHR:ARNT complex
Required for heterodimer formation with EPAS1
Required for heterodimer formation with HIF1A
Lysosomal amino acid transporter 1 homolog
Tyrosine-protein phosphatase non-receptor type 9
Loss of autophosphorylation and altered interaction with SHC1 and PLCG1; when associated with F-705 and F-706.
Loss of autophosphorylation; when associated with F-701 and F-705.
Loss of autophosphorylation; when associated with F-701 and F-706.
Spermatogenesis-associated protein 19, mitochondrial
Complement C1q tumor necrosis factor-related protein 6
Required for endoplasmic reticulum targeting
Acylamino-acid-releasing enzyme N-terminal
Important for surfactant activity and antibacterial properties
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Extracellular superoxide dismutase [Cu-Zn]
Superoxide dismutase copper/zinc binding
Heterogeneous nuclear ribonucleoprotein F
Heterogeneous nuclear ribonucleoprotein F, N-terminally processed
N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein F, N-terminally processed
Transcription initiation factor TFIID subunit 11
Inhibitor of nuclear factor kappa-B kinase subunit beta
Phosphoserine; by TBK1, PKC/PRKCZ and PDPK1
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
ADP-ribosylation factor GTPase-activating protein 2
WD repeat, SAM and U-box domain-containing protein 1
26S proteasome non-ATPase regulatory subunit 2
26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
ATP-binding cassette sub-family A member 17
POU domain, class 6, transcription factor 1
Potassium voltage-gated channel subfamily S member 1
Essential for receptor binding and receptor activation
ATP-binding cassette sub-family F member 1
FERM, ARHGEF and pleckstrin domain-containing protein 1
Tissue-type plasminogen activator chain A
Tissue-type plasminogen activator chain B
Affects PtdIns(4,5)P2-binding, plasma membrane-association but not binding to DCVs.
Mediates targeting and association with DCVs
tRNA modification GTPase GTPBP3, mitochondrial
Ectonucleoside triphosphate diphosphohydrolase 2
O-linked (Xyl...) (chondroitin sulfate) serine; alternate
O-linked (Xyl...) (heparan sulfate) serine; alternate
tRNA-splicing endonuclease subunit Sen15
Phosphatidylcholine-sterol acyltransferase
Reduced activity with 20-carbon phosphatidylcholine as substrate. Little change with 18-carbon phosphatidylcholine as substrate.
Required for localization in mitochondria
Required for localization in sarcoplasmic reticulum
Proton acceptor; for glutaminase activity
110-fold increase in the activation constant of NAG. Modifies the specificity for the activator: Binds Phe-NAG considerably better than NAG.
400-fold increase in the activation constant of NAG. 3-fold decrease in the reaction rate at saturation of NAG.
60-fold increase in the activation constant of NAG.
70-fold increase in the activation constant of NAG.
900-fold increase in the activation constant of NAG. 3-fold decrease in the reaction rate at saturation of NAG.
Anthranilate phosphoribosyltransferase homolog
Carbamoyl-phosphate synthase [ammonia], mitochondrial
MAP kinase docking motif; essential for its phosphorylation
Electrogenic sodium bicarbonate cotransporter 4
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
Homeodomain-interacting protein kinase 3
Reduces enzymatic activity but no effect on autophosphorylation; when associated with A-359.
Reduces enzymatic activity; but no effect on autophosphorylation; when associated with A-357.
Telomere repeat-binding factor dimerisation
Telomeric repeat-binding factor 2 Rap1-binding
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
Pterin-4-alpha-carbinolamine dehydratase
Reduced dehydratase activity. No impact on hydroxytetrahydrobiopterin-binding.
Microtubule-associated protein RP/EB family member 2
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
Zinc finger and BTB domain-containing protein 7A
>10-fold increase in inhibition of alpha-4-beta-2 nAChR by the conotoxin BuIA.
>10000-fold increase in inhibition of alpha-4-beta-2 nAChR by the conotoxin BuIA.
>1700-fold increase in inhibition of alpha-4-beta-2 nAChR by the conotoxin BuIA.
Neuronal acetylcholine receptor subunit alpha-4
3-hydroxyisobutyrate dehydrogenase, mitochondrial
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Decrease of activity with NAD, increase of activity with NADP.
Receptor-type tyrosine-protein phosphatase V
Endosomal/lysosomal proton channel TMEM175
Cell cycle checkpoint control protein RAD9B
Vasoactive intestinal polypeptide receptor 2
3-fold decrease in catalytic efficiency for NADH.
No significant effect on catalytic efficiency for NADH.
Potassium voltage-gated channel subfamily S member 2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
Mitochondrial 2-oxodicarboxylate carrier
N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Uncharacterized protein C12orf71 homolog
Soluble calcium-activated nucleotidase 1
Interchain (between alpha and beta subunits)
Calcium-responsive transcription coactivator
N-terminal auto-inhibitory domain; necessary for interaction with SMARCA4/BRG1
Necessary for interaction with CREBBP and for the recruitment of CREBBP to the nuclear bodies
Matrix extracellular phosphoglycoprotein
Strongly reduces interaction with RAB3A and modulation of exocytosis.
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Ankyrin repeat domain-containing protein 54
Aberrant protein folding and disordered structure.
Double-strand break repair protein MRE11
Interaction with BCL2L1 isoform Bcl-x(L) and inhibition of BCL2L1 anti-apoptotic activity
Zinc finger and BTB domain-containing protein 4
Abolishes binding to membranes containing phosphoinositol lipids; when associated with E-458.
Abolishes binding to membranes containing phosphoinositol lipids; when associated with E-504.
Abolishes binding to membranes containing phosphoinositol lipids; when associated with E-506.
Almost abolished binding to membranes containing phosphoinositol lipids; when associated with E-532.
Almost abolished binding to membranes containing phosphoinositol lipids; when associated with E-535.
No detectable impact on binding to PKCI.
Reduces binding to membranes containing phosphoinositol lipids by half. Abolishes binding to membranes containing phosphoinositol lipids; when associated with E-546.
Reduces binding to membranes containing phosphoinositol lipids by half; when associated with A-532.
Reduces binding to membranes containing phosphoinositol lipids by half; when associated with A-535.
Slightly reduced binding to membranes containing phosphoinositol lipids.
Slightly reduced binding to membranes containing phosphoinositol lipids; when associated with A-504.
Slightly reduced binding to membranes containing phosphoinositol lipids; when associated with A-506.
Strongly reduced binding to membranes containing phosphoinositol lipids.
Necessary for TATA box-bound TBP complex formation
Phosphothreonine; by MAPK1, MAPK3 and MAPK8
Transactivation domain C (highly charged)
Propionyl-CoA carboxylase alpha chain, mitochondrial
Ankyrin repeat domain-containing protein 34A
Leptin receptor overlapping transcript-like 1
Important for G protein-mediated signaling
LHFPL tetraspan subfamily member 1 protein
N-linked (GlcNAc...) (complex) asparagine; alternate
N-linked (GlcNAc...) (high mannose) asparagine; in brain; alternate
N-linked (GlcNAc...) (hybrid) asparagine; in brain; alternate
N-linked (GlcNAc...) asparagine; alternate
Rho guanine nucleotide exchange factor 2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I
Multiple myeloma tumor-associated protein 2 homolog
Multiple myeloma tumor-associated protein 2-like N-terminal
(Microbial infection) Cleavage; by C.botulinum neurotoxin type A (BoNT/A, botA)
(Microbial infection) Cleavage; by C.botulinum neurotoxin type E (BoNT/E)
Inhibits interaction with ZDHHC13 and ZDHHC17.
Interchain (between alpha-2-3 and delta-3 chains)
Voltage-dependent calcium channel subunit alpha-2-3
Voltage-dependent calcium channel subunit alpha-2/delta-3
Voltage-dependent calcium channel subunit delta-3
Actin, cytoplasmic 2, N-terminally processed
N-acetylglutamate; in Actin, cytoplasmic 2, N-terminally processed
Facilitates phospholipid membrane insertion
Phosphotyrosine; by SRC-type Tyr-kinases
Increased activity and autophosphorylation.
Loss of kinase activity; autophosphorylation and dimerization.
Increases activity towards medium and long chain fatty acids.
Increases activity towards medium chain fatty acids.
Activation domain; required for transcription activation
Cellular retinoic acid-binding protein 2
Contributes to high-affinity binding to cocaine
No effect on dopamine transport activity; when associated with G-403.
No effect on dopamine transport activity; when associated with G-404.
Reduced dopamine transport activity; when associated with A-356.
Reduced dopamine transport activity; when associated with A-359.
Reduced dopamine transport activity; when associated with G-356.
Reduced dopamine transport activity; when associated with G-359.
Significant loss of dopamine transport activity.
Cytochrome b-c1 complex subunit Rieske, mitochondrial
N-acetylthreonine; in Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed
Small ribosomal subunit protein RACK1, N-terminally processed
Important for autoinhibition of GTPase activity
Broad substrate specificity ATP-binding cassette transporter ABCG2
In Sprague-Dawley males; could be unrelated to gender.
Conserved oligomeric Golgi complex subunit 2 N-terminal
Binds liposomes in a calcium-independent manner; when associated with N-218.
Binds liposomes in a calcium-independent manner; when associated with N-220.
Double C2-like domain-containing protein beta
Loss of calcium-dependent binding to liposomes and altered fusion-promoting activity; when associated with A-158 and A-222.
Loss of calcium-dependent binding to liposomes and altered fusion-promoting activity; when associated with A-158 and A-360.
Loss of calcium-dependent binding to liposomes and altered fusion-promoting activity; when associated with A-222 and A-360.
Loss of calcium-independent binding to liposomes. Loss of interaction with the SNARE complex and altered fusion-promoting activity; when associated with E-237.
Loss of calcium-independent binding to liposomes. Loss of interaction with the SNARE complex and altered fusion-promoting activity; when associated with E-319.
Negatively regulates targeting to plasma membrane
Prevents diacylglycerol-induced localization to the plasma membrane. Probably prevents interaction with UNC13A.
17-beta-hydroxysteroid dehydrogenase type 3
Sterile alpha motif domain-containing protein 14
Plasma membrane ascorbate-dependent reductase CYBRD1
Disintegrin and metalloproteinase domain-containing protein 10
Phosphatidylinositol-glycan biosynthesis class X protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Potassium channel tetramerisation-type BTB
AP-4 complex subunit epsilon-1 C-terminal
Dehydrogenase/reductase SDR family member 7C
4-trimethylaminobutyraldehyde dehydrogenase
Important for agonist activity on V1aR/AVPR1A
Serine/threonine-protein phosphatase PGAM5, mitochondrial
Involved in nuclear speckle localization
Region N; interaction with decapping machinery
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Transforming growth factor beta-2 proprotein
Potassium voltage-gated channel subfamily D member 3
Interchain (between non-catalytic and catalytic chains)
Serine protease hepsin non-catalytic chain
Eukaryotic translation initiation factor 3 subunit B
NEDD8-activating enzyme E1 catalytic subunit
Mitochondrial import receptor subunit TOM34
DRY motif; important for ligand-induced conformation changes
Hydrophobic barrier that decreases the speed of ligand binding and dissociation
NPxxY motif; important for ligand-induced conformation changes and signaling
Guanylate cyclase soluble subunit alpha-2
Zinc finger CCCH-type with G patch domain-containing protein
Opioid growth factor receptor (OGFr) conserved
Peptidase M1 membrane alanine aminopeptidase
Atrial natriuretic peptide-converting enzyme
Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment
Atrial natriuretic peptide-converting enzyme, N-terminal propeptide
Atrial natriuretic peptide-converting enzyme, activated protease fragment
Impairs proteolytic processing and activation.
Interchain (between N-terminal propeptide and activated protease fragment chains)
Prevents proteolytic processing and activation; when associated with S-1087.
Prevents proteolytic processing and activation; when associated with S-968.
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Required for CTNNB1 accumulation and TCF transcription factor activity
Required for Wnt-activated receptor activity
Zinc finger and BTB domain-containing protein 44
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal
Necessary and sufficient for nuclear localization
Decrease in PCDH8-binding; alone or when associated with G-741.
Decrease in PCDH8-binding; when associated with P-740.
Become sensitive to the spider beta/delta-theraphotoxin-Pre1a, which inhibits inactivation of the channel.
Important for inhibition by tetrodotoxin
Important for rapid channel inactivation
In strain: COP; prostatic cancer cell lines.
No change in sensitivity to the spider beta/delta-theraphotoxin-Pre1a.
Sodium channel protein type 4 subunit alpha
Strongly reduced sensitivity to saxitoxin.
Strongly reduced sensitivity to tetrodotoxin.
25-hydroxycholesterol 7-alpha-hydroxylase
Eukaryotic translation initiation factor 4H
Leucine-rich repeat-containing protein 3
Nuclear distribution protein nudE homolog 1
S-palmitoyl cysteine; by ZDHHC2, ZDHHC3 and ZDHHC7
Decreased MST activity; increased rhodanese activity.
Interchain (with C-155 or C-264); redox-active
Large decrease in MST activity; some decrease in rhodanese activity.
Loss of both enzyme activities. Greatly reduced redox potential.
Slight decrease in MST activity; increased rhodanese activity.
RNA polymerase II subunit B1 CTD phosphatase Rpap2
Sodium/potassium-transporting ATPase subunit gamma
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Uncharacterized protein C11orf96 homolog
Abolishes phosphorylation, leading to degradation by the proteasome.
Beta-galactoside alpha-2,6-sialyltransferase 1
Loss of catalytic activity; when associated with A-350.
Loss of catalytic activity; when associated with A-361.
Loss of sialyltransferase activity and aberrant subcellular location.
No effect on protein stability, nor on catalytic activity.
Reduced KM/kcat values for CMP-Neu5Ac, no effect on kinetic constants for beta-Gal1,4-GlcNAc.
Small decrease of sialyltransferase activity.
Potassium voltage-gated channel subfamily A member 3
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole
Large neutral amino acids transporter small subunit 1
Pleckstrin homology domain-containing family G member 5
Anaphase-promoting complex subunit 4 long
Glycerol-3-phosphate dehydrogenase, mitochondrial
Essential for cell membrane localization and transport activity
In isoform 2, isoform 3, isoform 4 and isoform 5.
Nuclear receptor subfamily 0 group B member 2
Amyloid-beta A4 precursor protein-binding family A member 2
Important for association with membranes
N-acetylalanine; in cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
cAMP-dependent protein kinase type I-alpha regulatory subunit
cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
O-(3'-phospho-DNA)-tyrosine intermediate
WAP four-disulfide core domain protein 2
Elongation factor 1 beta central acidic region eukaryote
Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange
Essential for specifying elongation versus initiation step of the polyglycylase activity
Isoaspartyl peptidase/L-asparaginase alpha chain
Isoaspartyl peptidase/L-asparaginase beta chain
Important for selectivity against fructose
Solute carrier family 2, facilitated glucose transporter member 3
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
Endoplasmic reticulum vesicle transporter C-terminal
Endoplasmic reticulum vesicle transporter N-terminal
35-fold decrease in inhibition of PP1-alpha.
Arachidonate 5-lipoxygenase-activating protein
Matrix metalloproteinase-23, soluble form
N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein G; alternate
N-acetylvaline; in Heterogeneous nuclear ribonucleoprotein G, N-terminally processed
RNA-binding motif protein, X chromosome, N-terminally processed
Tyrosine-protein phosphatase non-receptor type 21
Protein-glutamine gamma-glutamyltransferase K
GDP-fucose protein O-fucosyltransferase 2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
C; actin-binding and synaptic-vesicle binding
ATP-binding cassette sub-family C member 8
H/ACA ribonucleoprotein complex non-core subunit NAF1
Ras association domain-containing protein 9
Platelet-activating factor acetylhydrolase 2, cytoplasmic
5-aminolevulinate synthase, erythroid-specific, mitochondrial
Glucan phosphatase signature motif CXAGXGR
Polypeptide N-acetylgalactosaminyltransferase 13
Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cations
Peptidyl-prolyl cis-trans isomerase-like 3
Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil
Voltage-dependent calcium channel gamma-2 subunit
G2 and S phase-expressed protein 1 N-terminal
Proline/serine-rich coiled-coil protein 1
Calcium and integrin-binding family member 2
Interferon-related developmental regulator C-terminal
Interferon-related developmental regulator N-terminal
Processed sterol regulatory element-binding protein 2
Sterol regulatory element-binding protein 2
In isoform 1834, isoform 1759 and isoform EB.
In isoform EA2, isoform EB and isoform B1.
Lutropin-choriogonadotropic hormone receptor
No change in binding or cAMP production.
Trapped intracellularly and does not appear to become mature; when associated with A-647.
Trapped intracellularly and does not appear to become mature; when associated with A-648.
RZZ complex subunit KNTC1/ROD C-terminal
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
Sodium-dependent organic anion transporter
Inactive hydroxysteroid dehydrogenase-like protein 1
In isoform 4, isoform 5, isoform 6 and isoform 7.
Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
Major facilitator superfamily associated
Voltage-dependent calcium channel gamma-5 subunit
All trans-polyprenyl-diphosphate synthase PDSS2
Processed PDZ domain-containing protein 2
Abolishes enzyme activity, but has no effect on NADPH binding.
Impairs interaction with MAPRE1 and association with microtubules.
No effect on interaction with MAPRE1 and association with microtubules.
Voltage-gated potassium channel subunit beta-2
Rab proteins geranylgeranyltransferase component A 1
Impairs N-glycosylation; when associated with Q-109; Q-116 and Q-122. Significantly decreases taurocholate; when associated with Q-109; Q-116 and Q-122. Significantly decreases protein expression; when associated with Q-109; Q-116 and Q-122. Affects protein localization at the apical membrane;when associated with Q-109; Q-116 and Q-122.
Impairs N-glycosylation; when associated with Q-109; Q-116 and Q-125. Significantly decreases taurocholate; when associated with Q-109; Q-116 and Q-125. Significantly decreases protein expression; when associated with Q-109; Q-116 and Q-125. Affects protein localization at the apical membrane; when associated with Q-109; Q-116 and Q-125.
Impairs N-glycosylation; when associated with Q-109; Q-122 and Q-125. Significantly decreases taurocholate; when associated with Q-109; Q-122 and Q-125. Significantly decreases protein expression; when associated with Q-109; Q-122 and Q-125. Affects protein localization at the apical membrane; when associated with Q-109; Q-122 and Q-125. Does not affect protein localization at the apical membrane; when associated with Q-109; Q-122 and Q-125.
Impairs N-glycosylation; when associated with Q-116; Q-122 and Q-125. Significantly decreases taurocholate; when associated with Q-116; Q-122 and Q-125. Significantly decreases protein expression; when associated with Q-116; Q-122 and Q-125. Affects protein localization at the apical membrane; when associated with Q-116; Q-122 and Q-125. Does not affect protein localization at the apical membrane.
Pleckstrin homology domain-containing family M member 1
Killer cell lectin-like receptor subfamily B member 1A
Ancestral coatomer element 1 Sec16/Sec31
Mothers against decapentaplegic homolog 5
Gamma-aminobutyric acid receptor subunit beta-1
Necessary for interaction with HDAC3 and transcriptional repression
(Microbial infection) Cleavage; by C.botulinum neurotoxin type C (BoNT/C)
Calcium-transporting ATPase type 2C member 2
Endonuclease/exonuclease/phosphatase family domain-containing protein 1
Required for ATPase and aminophospholipid flippase activity
ATP-sensitive inward rectifier potassium channel 15
Small ribosomal subunit protein uS15 N-terminal
Transcription termination factor 1, mitochondrial
SH3 domain-containing kinase-binding protein 1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Ubiquitin/ISG15-conjugating enzyme E2 L6
CAP-Gly domain-containing linker protein 4
Decreased methylation. Does not affect subcellular location.
Heterogeneous nuclear ribonucleoproteins A2/B1
Abrogates GTP-binding and nucleolar localization.
Guanine nucleotide-binding protein-like 3
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
Receptor-type tyrosine-protein phosphatase R
Acyl-CoA-binding domain-containing protein 4
Retinoblastoma-associated protein C-terminal
Retinoblastoma-associated protein N-terminal
3-fold decrease of affinity for phosphoenolpyruvate.
Abolished phosphoenolpyruvate carboxykinase activity; decreased affinity for oxaloacetate.
Decreased phosphorylation and increased acetylation levels.
Destabilization of the closed state of the omega-loop, resulting in decreased capture rates for the weaker binding substrates associated with catalysis in the phosphoenolpyruvate to oxaloacetate direction.
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Dimethylaniline monooxygenase [N-oxide-forming] 2
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)
Inositol polyphosphate-4-phosphatase type I A
Telomeric single stranded DNA binding POT1/Cdc13
NPC1-like intracellular cholesterol transporter 1
Regulator of microtubule dynamics protein 3
Fibronectin type III domain-containing protein 5
Protein phosphatase 1 regulatory subunit 14C
S100/CaBP-9k-type calcium binding subdomain
Fasciculation and elongation protein zeta-1
Pleckstrin homology-like domain family A member 3
ATP-binding cassette subfamily C member 4
Tubulin epsilon and delta complex protein 1
N6,N6,N6-trimethyllysine; by METTL21A; in vitro
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Phytanoyl-CoA hydroxylase-interacting protein-like
Phosphatidylinositol-specific phospholipase C X
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
Inactive ubiquitin carboxyl-terminal hydrolase 54
Apoptosis-inducing factor 1, mitochondrial
Mitochondrial apoptosis-inducing factor C-terminal
In isoform LIMK2B, isoform LIMK2C and isoform LIMK2D.
Interleukin-1 receptor type 2, membrane form
Interleukin-1 receptor type 2, soluble form
Trafficking protein particle complex subunit 2-like protein
Glutaminase liver isoform, mitochondrial
Dehydrogenase/reductase SDR family member 6
Bone morphogenetic protein receptor type-1A
TATA box-binding protein-associated factor, RNA polymerase I, subunit C
Eukaryotic translation initiation factor 2 subunit 1
Peroxisome proliferator-activated receptor gamma
ATP-binding cassette sub-family B member 6
Histone RNA hairpin-binding protein RNA-binding
Eukaryotic translation initiation factor 3 subunit H
Glutamate dehydrogenase 1, mitochondrial
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Required for interaction with RNA-binding proteins DDX5, HNRNPH2 and SRSF1 and with mRNAs
Choloylglycine hydrolase/NAAA C-terminal
N-acylethanolamine-hydrolyzing acid amidase
N-acylethanolamine-hydrolyzing acid amidase subunit alpha
N-acylethanolamine-hydrolyzing acid amidase subunit beta
Inactive 2'-5'-oligoadenylate synthase 1B
Important for dimerization and for HRAS activation
Important for lipid binding and for stimulation of cell migration
Uncharacterized protein C11orf24 homolog
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
Calcium/calmodulin-dependent protein kinase kinase 2
Killer cell lectin-like receptor subfamily I member 1
Leucine-rich repeat-containing protein 42
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Inhibits binding to HRAS by 19% and phospholipase stimulation by HRAS by 30%. Inhibits binding to HRAS by 97% and phospholipase stimulation by HRAS by 86%; when associated with A-2150.
Inhibits binding to HRAS by 59% and phospholipase stimulation by HRAS by 51%. Inhibits binding to HRAS by 97% and phospholipase stimulation by HRAS by 86%; when associated with A-2152.
Inhibits binding to HRAS by 67% and phospholipase stimulation by HRAS by 47%. Inhibits binding to HRAS by 97% and phospholipase stimulation by HRAS by 94%; when associated with E-2150.
Inhibits binding to HRAS by 99% and phospholipase stimulation by HRAS by 94%. Inhibits binding to HRAS by 97% and phospholipase stimulation by HRAS by 94%; when associated with E-2152.
Required for activation by RHOA, RHOB, GNA12, GNA13 and G-beta gamma
Succinate--hydroxymethylglutarate CoA-transferase
Gamma-aminobutyric acid receptor subunit gamma-3
Natural cytotoxicity triggering receptor 3
Abolishes agrin-dependent activation and autophosphorylation.
Muscle, skeletal receptor tyrosine protein kinase
Reduces LRP4- and AGRIN-dependent phosphorylation. Reduces DOK7-dependent phosphorylation. Reduces agrin-dependent AChR aggregation in neuromuscular junction. Reduces interaction with DOK7.
Strongly reduced agrin-dependent activation and autophosphorylation.
T-cell surface glycoprotein CD3 zeta chain
Target of rapamycin complex 2 subunit MAPKAP1
Pre-rRNA-processing protein Ipi1 N-terminal
Complete loss of autocatalytic processing.
NACHT, LRR and PYD domains-containing protein 1a allele 1
NACHT, LRR and PYD domains-containing protein 1a, C-terminus
NACHT, LRR and PYD domains-containing protein 1a, N-terminus
ATP-binding cassette sub-family A member 7
ADP-ribosylation factor-related protein 1
Actin, alpha cardiac muscle 1, intermediate form
Almost complete loss of activity; when associated with A-29.
Almost complete loss of activity; when associated with A-30.
Almost complete loss of activity; when associated with A-31.
Almost complete loss of activity; when associated with A-32.
Complete loss of activity. Abolishes interaction with RPTOR. Reduces phosphorylation. Loss of phosphorylation at T-412 and T-444.
Loss of activity towards ribosomal protein S6 and loss of phosphorylation at Thr-252.
Loss of activity towards ribosomal protein S6 and reduced phosphorylation at Thr-412.
Loss of activity towards ribosomal protein S6 and reduces phosphorylation at Thr-252.
Loss of activity towards ribosomal protein S6 without effect on phosphorylation status.
Loss of activity towards ribosomal protein S6.
Mimics phosphorylation. Constitutive active. No effect on activity towards ribosomal protein S6.
No effect on sensitivity to wortmannin and rapamycin; when associated with D-434, D-441 and D-444.
No effect on sensitivity to wortmannin and rapamycin; when associated with D-434, D-441, and D-447.
No effect on sensitivity to wortmannin and rapamycin; when associated with D-434, D-D-444 and D-447.
No effect on sensitivity to wortmannin and rapamycin; when associated with D-441, D-444 and D-447.
Phosphothreonine; by MTOR, NEK6 and NEK7
10-fold increase in affinity for calcium.
12 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X
Complete loss of calcium-binding and calcium-dependent phospholipid binding activity.
Moderate increase in affinity for calcium.
Important for interaction with phosphotyrosine-binding proteins
Mitochondrial import inner membrane translocase subunit Tim21
Acyl-coenzyme A amino acid N-acyltransferase 2
Proprotein convertase subtilisin/kexin type 5
Isocitrate dehydrogenase [NADP], mitochondrial
Sterol regulatory element-binding protein cleavage-activating protein
Histone acetyl transferase HAT1 N-terminal
Histone acetyltransferase type B catalytic subunit
Gamma-aminobutyric acid receptor-associated protein-like 1
In chemically induced renal carcinogenesis.
Calcium permeable stress-gated cation channel 1
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Golgi-associated RAB2 interactor protein 1A
Chemokine binding, important for signaling
Important for chemokine binding and signaling
Involved in dimerization; when bound to chemokine
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
N-acetylvaline; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Pleckstrin homology domain-containing family B member 1
EP300-interacting inhibitor of differentiation 3
Non-structural maintenance of chromosome element 4 C-terminal
Phosphoserine; by CDC42BP, CIT, MLCK, PAK1, ROCK1, ROCK2, DAPK1, DAPK2 and ZIPK/DAPK3
Phosphothreonine; by MLCK, CIT and ROCK2
Minichromosome maintenance domain-containing protein 2
Actin-related protein 2/3 complex subunit 1B
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
Mitochondrial import inner membrane translocase subunit Tim13
Calcium/calmodulin-dependent protein kinase type IV
Increases Ca(2+)/calmodulin-independent activity.
Loss of kinase activity; confers cytoplasmic localization.
Loss of kinase activity; confers nuclear localization.
No decrease in Ca(2+)/calmodulin-dependent activity after activation by CaMKKs.
Does not abolish the ability to suppress the growth defect of yeast lacking VRP1.
WAS/WASL-interacting protein family member 3
Serine/threonine-protein kinase MRCK alpha
Abolishes sumoylation. Abolishes location at cilia in the olfactory epithelium.
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)
Cleavage and polyadenylation specificity factor subunit 5
Necessary for interactions with PAPOLA and PABPN1
Phosphatidylinositol polyphosphate 5-phosphatase type IV
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Lymphocyte antigen 6 complex locus protein G6d
Increase in the sensitivities to dipyridamole and dilazep.
Increase in the transport capacity for adenosine but no change in substrate affinity. Increase in the sensitivities to dipyridamole and dilazep.
B box and SPRY domain-containing protein
Central conserved domain (CCD); required for localization to endoplasmic reticulum exit sites
Abolishes myristoylation and palmitoylation.
Expected to have lost GTPase activity; inhibits the forskolin-mediated increase of cellular cAMP levels. Does not inhibit interaction with RGS14 at centrosomes.
Guanine nucleotide-binding protein G(i) subunit alpha-1
Increases basal GDP exchange rate and inhibits the forskolin-mediated increase of cellular cAMP levels.
Increases basal GDP exchange rate; mildly decreases receptor-stimulated GDP exchange.
Increases basal GDP exchange rate; no effect on receptor-stimulated GDP exchange.
Inhibits interaction with RGS14. Does not inhibit interaction with RIC8A.
Mildly impairs receptor binding; mildly decreases basal and receptor-stimulated GDP exchange.
No effect on basal GDP exchange rate; mildly decreases receptor-stimulated GDP exchange.
Strongly increases basal GDP exchange rate; mildly decreases receptor-stimulated GDP exchange.
Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial
Palmitoyl-protein thioesterase ABHD10, mitochondrial
Guanylate cyclase soluble subunit beta-2
Mitochondrial import inner membrane translocase subunit TIM44
Acetylcholinesterase collagenic tail peptide
Transactivation AF-1; required for ligand-independent transactivation function
Transactivation AF-2; required for ligand-dependent transactivation function; mediates interaction with CCAR2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Acyl-coenzyme A synthetase ACSM5, mitochondrial
Abolishes interaction with DLG4. Does not redistribute DLG4 to microtubules. Associates with microtubules.
Abolishes interaction with DLG4. Strongly abolishes interaction with DLG4; when associated with D-100.
Abolishes interaction with DLG4. Strongly abolishes interaction with DLG4; when associated with E-98.
Mitochondrial import receptor subunit TOM70
Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal
Important for ligand binding and specificity
Pituitary adenylate cyclase-activating polypeptide type I receptor
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
Microtubule-associated protein RP/EB family member 3
DNA polymerase alpha subunit B N-terminal
DNA polymerase alpha/delta/epsilon subunit B
Translin-associated factor X-interacting protein 1 N-terminal
Membrane-associated progesterone receptor component 1
Necessary for stimulating PAPOLA activity
Sufficient for interaction with CPSF1 and CSTF3
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Abolishes O-glycosylation and localization at the cell surface; when associated with A-44 and A-77.
Abolishes O-glycosylation and localization at the cell surface; when associated with A-44; A-50; A-51; A-52; A-56; A-57; A-58; A-60; A-61; A-62; A-63; A-65; A-76; A-68; A-69 and A-71.
Abolishes O-glycosylation and localization at the cell surface; when associated with A-50; A-51; A-52; A-56; A-57; A-58; A-60; A-61; A-62; A-63; A-65; A-76; A-68; A-69; A-71 and A-77.
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Required for correct folding and localization
Cysteine sulfonic acid (-SO3H); alternate
Fails to dissociate from KEAP1 after PKC activation.
Mediates interaction with CHD6 and is necessary to activate transcription
Nuclear factor erythroid 2-related factor 2
Dihydropyrimidine dehydrogenase [NADP(+)]
Queuine tRNA-ribosyltransferase catalytic subunit 1
RNA binding; important for wobble base 34 recognition
Deubiquitinating enzyme MINDY-3/4 conserved
Important for interaction with target DNA
Nitration by tetranitromethane destroys a Ca(2+) binding site and inactivates enzyme
Glandular kallikrein-7, submandibular/renal
NPC intracellular cholesterol transporter 2
Chorion-specific transcription factor GCMa
Nuclear transcription factor Y subunit beta
Gamma-aminobutyric acid receptor subunit gamma-2
ATPase activity reduced by 60%-70%. ATPase activity reduced by 92%; when associated with Q-193.
ATPase activity reduced by 60%-70%. ATPase activity reduced by 92%; when associated with T-139.
Outer mitochondrial transmembrane helix translocase
Abolishes ability to regulate sodium/potassium-transporting ATPase activity following increases in intracellular sodium.
6-phosphogluconate dehydrogenase C-terminal
6-phosphogluconate dehydrogenase, decarboxylating
Axonemal dynein light intermediate polypeptide 1
Increases specific activity against PNPC by 6-fold and against PNPA by 8.7-fold, no activity on cholesteryl oleate. Increases specific activity against PNPC by 7.5-fold and against PNPA by 3.6-fold, and increases cholesteryl esterase activity by 2.7 fold; when associated with I-423.
Increases specific activity against PNPC by 8-fold, does not increase activity against PNPA, no activity on cholesteryl oleate. Increases activity on PNPC compared to activity on PNPA; when associated with R-186; T-491 and E-492. Increases specific activity against PNPC by 7.5-fold and against PNPA by 3.6-fold, and increases cholesteryl esterase activity by 2.7 fold; when associated with S-506.
No effect on the hydrolysis of PNPC or PNPA, no activity on cholesteryl oleate. No effect on the hydrolysis of PNPC or PNPA, no activity on cholesteryl oleate; when associated with E-492; or with T-491 and E-492. Increases activity on PNPC compared to activity on PNPA; when associated with I-423; T-491 and E-492.
No effect on the hydrolysis of PNPC or PNPA, no activity on cholesteryl oleate; when associated with R-186 and E-492. Increases activity on PNPC compared to activity on PNPA; when associated with R-186; I-423 and E-492.
No effect on the hydrolysis of PNPC or PNPA, no activity on cholesteryl oleate; when associated with R-186; or with R-186 and T-491. Increases activity on PNPC compared to activity on PNPA; when associated with R-186; I-423 and T-491.
Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp
Inositol-tetrakisphosphate 1-kinase N-terminal
Required to release iHOPS from membranes
Transmembrane and ubiquitin-like domain-containing protein 1
Regenerating islet-derived protein 3-alpha 15 kDa form
Regenerating islet-derived protein 3-alpha 16.5 kDa form
Eukaryotic translation initiation factor 3 subunit J
Promotes stable association with the 40S ribosome
Ankyrin repeat and SAM domain-containing protein 6
Decreased NEK8-binding, but no effect on INVS-binding; when associated with A-129.
Decreased NEK8-binding, but no effect on INVS-binding; when associated with A-209.
In cy; loss of ability to self-associate, does not affect interaction with Bicc1; loss of interaction with ANKS3.
No effect on interaction with INVS, NEK8 ANDNPHP3, nor on ciliary localization. Unable to rescue ANKS6 knockout in a heterologous system.
ADP-ribosylation factor-like protein 2-binding protein
Translocon-associated protein subunit delta
Mothers against decapentaplegic homolog 2
Jupiter microtubule associated homolog 2
Fumarylacetoacetate hydrolase domain-containing protein 2
Abolishes interaction with DNM1, SYNJ1 and WASL.
No effect on membrane-binding. Reduces membrane tubulation.
Protein kinase C and casein kinase substrate in neurons protein 1
Reduces membrane tubulation; when associated with A-276.
Reduces membrane tubulation; when associated with A-280.
Reduces membrane-binding. Abolishes membrane tubulation.
Reduces membrane-binding. Abolishes membrane tubulation; when associated with Q-127.
Reduces membrane-binding; when associated with Q-130. Abolishes membrane tubulation.
Required for inhibition of CLOCK-BMAL1-mediated transcription
Important for formation of active hexamer structure
Interaction with the C-terminus of NDC80 and the SPBC24-SPBC25 subcomplex
Interaction with the N-terminus of NDC80
LHFPL tetraspan subfamily member 5 protein
Myelin-associated oligodendrocyte basic protein
28 kDa heat- and acid-stable phosphoprotein
Casein kinase substrate phosphoprotein PP28
N6-acetyllysine; by KAT2A and KAT2B; alternate
No effect on DNA-binding. Increases transactivation activity.
No effect on DNA-binding. Loss of transactivation activity. Loss of hepatocyte proliferation induction by TGFA.
Phosphothreonine; by RPS6KA1, CDK2 and MAPK
Required for MYC transcriptional repression
Essential for interaction with SGTA and TTC1
Essential for interaction with SMYD3, TSC1 and STIP1/HOP
Decreased activity for acidic amino acids at position P3, whereas the activity against basic amino is increased.
Decreased secretion without affecting the protease activity.
Mediates preference for Asp-containing substrates
CXXC motif containing zinc binding protein
Microtubule-associated serine/threonine-protein kinase 1
Guanine nucleotide-binding protein G(olf) subunit alpha
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Involved in sugar-binding/transport and inhibitor binding
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Voltage-dependent calcium channel alpha-1 subunit IQ
Ubiquitin-activating enzyme E1 C-terminal
Putative protein-lysine deacylase ABHD14B
Dendritic cell-specific transmembrane protein-like
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Transforming growth factor beta-1-induced transcript 1 protein
FAST kinase domain-containing protein 3, mitochondrial
cGMP-specific 3',5'-cyclic phosphodiesterase
Coiled-coil domain-containing protein 22
Sufficicient and required for interaction with CCDC93
Solute carrier organic anion transporter family member 1A5
MAP kinase-interacting serine/threonine-protein kinase 2
Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity
Zinc finger and BTB domain-containing protein 10
DNA-(apurinic or apyrimidinic site) endonuclease
DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial
Necessary for interaction with NPM1 and for efficient rRNA binding
Necessary for interaction with YBX1, binding to RNA, association together with NPM1 to rRNA, endoribonuclease activity on abasic RNA and localization in the nucleoli
Pericentrin/AKAP-450 centrosomal targeting
Abolishes expression at the cell membrane. Abolishes lactate transport across the cell membrane without affecting expression at the cell membrane; when associated with E-306.
Abolishes expression at the cell membrane. Abolishes lactate transport across the cell membrane without affecting expression at the cell membrane; when associated with R-302.
No effect on expression at the cell membrane, but abolishes lactate transport across the cell membrane.
No effect on expression at the cell membrane. No effect on lactate transport across the cell membrane.
Loss of magnesium-binding; when associated with A-73, A-109 and Q-120.
Loss of magnesium-binding; when associated with A-73, Q-84 and A-109.
Loss of magnesium-binding; when associated with A-73, Q-84 and Q-120.
Loss of magnesium-binding; when associated with Q-84, A-109 and Q-120.
Arf-GAP with dual PH domain-containing protein 2
No loss of InsP4 binding. Almost complete loss of InsP4 binding; when associated with C-151.
Nuclear receptor subfamily 2 group C member 1
Moderate decrease in ligand binding. 200-fold reduction of agonist-mediated cAMP inhibition.
Small decrease in agonist binding. 18-fold reduction of agonist-mediated cAMP inhibition.
Small decrease in agonist binding. Complete loss of agonist-mediated cAMP inhibition.
Heme-copper oxidase subunit III family profile
Impairs expression at the plasma membrane.
In microcytic anemia; impairs metal ion transport.
Loss of proton-coupled Fe(2+) transporter activity.
Natural resistance-associated macrophage protein 2
Reduces expression at the plasma membrane. Does not affect H(+)-coupled Fe(2+) transport.
Uncouples Fe(2+) and H(+) fluxes. Mediates facilitative Fe(2+) transport independently of pH gradient.
Tryptophan synthase beta chain-like PALP
Sodium/potassium-transporting ATPase subunit alpha-4
Polyunsaturated fatty acid lipoxygenase ALOX15B
Bipartite nuclear localization signal; in isoform 2
Required for association with membranes and function in neurite spine formation
Cation channel sperm-associated auxiliary subunit delta
N-acetyllactosaminide alpha-1,3-galactosyltransferase
Necessary for association with microtubules
Necessary for the microtubule-organizing center localization
Necessary for the mitochondrial aggregation and genome destruction
Membrane-associated progesterone receptor component 2
Zinc finger C2HC domain-containing protein 1C
Important for nucleosome binding properties
Exocyst complex subunit Sec15 C-terminal
Rho family-interacting cell polarization regulator 1
Platelet-activating factor acetylhydrolase IB subunit alpha
Required for self-association and interaction with PAFAH1B2 and PAFAH1B3
Cell division cycle-associated protein 7
Cilia- and flagella-associated protein 418
Spliceosome-associated protein CWC15 homolog
Oncostatin-M-specific receptor subunit beta
Prostaglandin F2 receptor negative regulator
Potassium voltage-gated channel subfamily A member 4
V-set domain-containing T-cell activation inhibitor 1
N-acetylserine; in WD40 repeat-containing protein SMU1, N-terminally processed
WD40 repeat-containing protein SMU1, N-terminally processed
Transcription elongation factor A protein-like 8
Solute carrier family 2, facilitated glucose transporter member 1
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Failed to protect against extrinsic and intrinsic apoptotic pathways; when associated with F-31. Not interferes with DISC assembly; when associated with F-31. Promotes BAX activation; when associated with F-31.
Failed to protect against extrinsic and intrinsic apoptotic pathways; when associated with R-69. Not interferes with death-inducing signaling complex (DISC) assembly; when associated with R-69. Promotes BAX activation; when associated with R-69.
Not phosphorylated by CK2. Loses the ability to block CASP8-, FAS-, or TNFRSF1A-induced apoptosis. Prevents translocation to mitochondria. Significantly decreases resistance to hydrogen peroxide-induced cell death. Doesn't interact with PPM1G, BAX and CASP2. Doesn't inhibit CASP2 and CASP3 activation. Doesn't was inhibit CASP8-induced apoptosis.
Significantly enhances resistance against hydrogen peroxide- and induced by isoproterenol or aldosterone-induced cell death.
Heat shock factor-binding protein 1-like protein 1
Mediator of RNA polymerase II transcription subunit 28
Strongly decreased ability to mediate rapid channel inactivation.
Gamma-aminobutyric acid type B receptor subunit 2
T-cell-specific surface glycoprotein CD28
Uncharacterized protein C1orf131 homolog
Regulatory factor X-associated protein RFXANK-binding
Abolishes inhibition by phosphorylation.
No current (homomultimers); one fourth of the WT current (heteromultimers).
Potassium voltage-gated channel subfamily E member 1
Effector domain involved in lipid-binding and calmodulin-binding
ATP-binding cassette sub-family C member 2
Recruits mitochondria at the lipid droplet surface
RNA 2-O ribose methyltransferase substrate binding
Complete loss of receptor functionality.
Histo-blood group ABO system transferase 2
Sperm mitochondrial-associated cysteine-rich protein
Heterogeneous nuclear ribonucleoprotein L
Glutamate receptor ionotropic, kainate 4
DNA-directed RNA polymerase III subunit RPC9
C-type lectin domain family 2 member D11
Tyrosine-protein phosphatase non-receptor type 7
Minimal region for the interaction with PKD2
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Structure-specific endonuclease subunit SLX1
ATP synthase membrane subunit K, mitochondrial
Does not alter sorting to large dense granules.
Impairs sorting to large dense granules. Delivered to the plasma membrane instead.
Impairs sorting to large dense granules. Delivered to the plasma membrane instead. Abolishes exocytosis in dendrites. Reduces exocytosis in axons.
Loss of activity. Abolishes histamine uptake.
Leukocyte-associated immunoglobulin-like receptor 1
EF-hand calcium-binding domain-containing protein 3
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Major antigenic determinant (of neutral salt-extracted rat skin collagen)
A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding
Transcription factor TFIIE alpha subunit C-terminal
Abolishes binding to and activation of GNAI3.
Abolishes binding to and activation of GNAI3; when associated with A-315.
Abolishes binding to and activation of GNAI3; when associated with A-319.
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Leucine-rich repeat transmembrane neuronal protein 1
Coiled-coil domain-containing protein 141
Heterogeneous nuclear ribonucleoprotein H2
Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed
N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed
Discoidin, CUB and LCCL domain-containing protein 2
Could be involved in the assembly of the multisynthetase complex
Conserved cysteine within steroid binding domain
Abolishes cleavage and shedding of ectodomain; when associated with A-94.
Abolishes cleavage and shedding of ectodomain; when associated with G-91.
Coxsackievirus and adenovirus receptor homolog
PHD and RING finger domain-containing protein 1
snRNA-activating protein complex subunit 3
Autoinhibitory acidic region; in absence of 7SK snRNA interacts with the basic region preventing interaction with P-TEFb and modulating subcellular localization
Basic region; mediates nuclear localization and interaction with 7SK snRNA and NR3C1
Required for inhibition of ESR1-dependent transcription
Eukaryotic translation initiation factor 2-alpha kinase 1
'Ionic lock' involved in activated form stabilization
Plays an important role in the conformation switch to the active conformation
Gamma tubulin complex component C-terminal
Gamma tubulin complex component protein N-terminal
Necessary for interaction with NR6A1 C-terminus
Necessary for interaction with NR6A1 N-terminus
Beclin 1-associated autophagy-related key regulator
Important for interaction with G proteins
Parathyroid hormone/parathyroid hormone-related peptide receptor
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Dual specificity testis-specific protein kinase 1
Loss of autophosphorylation site, loss of kinase activity.
Loss of autophosphorylation site, no effect on kinase activity.
Loss of kinase and autophosphorylating activity. Abolishes TESK1-induced actin stress fiber formation. No effect on interaction with YWHAB, SPRY2 or SPRED1. No effect on TESK1-mediated dephosphorylation of SPRY2.
Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation
ATP-sensitive inward rectifier potassium channel 10
Ubiquitin carboxyl-terminal hydrolase 46
Important for autoinhibition of adenylyltransferase activity
Leucine-rich repeat-containing G-protein coupled receptor 4
Selenocysteine insertion sequence-binding protein 2
Zinc finger and BTB domain-containing protein 38
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Mitochondrial import receptor subunit TOM40B
Nuclear distribution protein nudE-like 1
Required for localization to the centrosome and interaction with dynein, dynactin, tubulin gamma, PCM1 and PCNT
Abolishes phosphorylation by MAPK, increases functional activity and enhances retention in peripheral membranes; when associated with 1476-A--A-1483.
Abolishes phosphorylation by MAPK, increases functional activity and enhances retention in peripheral membranes; when associated with A-1451.
Disrupts GTP-binding. No direct effect on GAP activity 'in vitro' but affects the activity regulation 'in vivo'.
Has GTPase activity, required for proper localization
Required for phospholipid binding and regulation of the substrate preference
No effect on activation by PKA. Abolishes activation by PKA; when associated with A-959.
Slightly decreases activation by PKA. Abolishes activation by PKA; when associated with A-960.
Reduced interaction with RELA. Reduced translocation to the nucleus. Reduced activation of NF-kappa-B transcription factor activity.
C-terminal transmembrane transporter domain
Mitochondrial adenyl nucleotide antiporter SLC25A25
Alanine--glyoxylate aminotransferase 2, mitochondrial
Mas-related G-protein coupled receptor member X1
Isochorismatase domain-containing protein 2
Abolishes interaction with FLRT2; when associated with N-89.
Abolishes interaction with FLRT2; when associated with T-91.
Large ribosomal subunit protein uL6 alpha-beta
Tumor necrosis factor receptor superfamily member 21
Phosphotyrosine; by autocatalysis and SRC
Vascular endothelial growth factor receptor 3
Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
Important for CDC42-dependent filopodia induction
Natural killer cell receptor 2B4 immunoglobulin
V-set and transmembrane domain-containing protein 5
Histo-blood group ABO system transferase 1
Calmodulin-regulated spectrin-associated protein 2
Vitamin K epoxide reductase complex subunit 1-like protein 1
Required for response to bacterial lipopolysaccharide (LPS)
Functional determinant of NMDA receptors
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Abolishes affinity for POPC/POPS in the absence of Ca(2+); when associated with E-714.
Abolishes affinity for POPC/POPS in the absence of Ca(2+); when associated with E-718.
Only retains weak enzyme activity and abolishes the ability of isoform 4 to act as a negative regulator.
Abolishes targeting to the basolateral plasma membrane.
Dopamine fails to increase phosphoinositide-3 kinase activity and to promote its interaction with Na(+)/K(+) ATPase.
Results in altered sodium and potassium transport.
Sodium/potassium-transporting ATPase subunit alpha-1
Strong loss of GKAP ubiquitination; when associated with S-22.
Strong loss of GKAP ubiquitination; when associated with S-25.
Protein phosphatase 1 regulatory subunit 15B N-terminal
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
DET1- and DDB1-associated protein 1 N-terminal
RNA 3'-terminal phosphate cyclase insert
Alpha-ketoglutarate-dependent dioxygenase FTO
Alpha-ketoglutarate-dependent dioxygenase FTO catalytic
Loop L1; predicted to block binding of double-stranded DNA or RNA
Dynein regulatory complex protein 1/2 N-terminal
Cytochrome c oxidase subunit 5A, mitochondrial
Leucine-rich repeat transmembrane protein FLRT3
Cellular retinoic acid-binding protein 1
Methionyl-tRNA synthetase anticodon-binding
Endothelial cell-selective adhesion molecule
Found in WKY/NCrl rat, a rat model of attention deficit hyperactive disorder. Always found associated with G-512. 2-fold increase in binding CHP1; when associated with G-512.
Found in WKY/NCrl rat, a rat model of attention deficit hyperactive disorder. Always found associated with R-534. 2-fold increase in binding CHP1; when associated with R-534.
Vacuolar protein sorting-associated protein 13 DH-like
Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding
Vacuolar protein sorting-associated protein 13 extended chorein
UbiA prenyltransferase domain-containing protein 1
Breast cancer anti-estrogen resistance protein 1
Saccharopine dehydrogenase-like C-terminal
Saccharopine dehydrogenase-like oxidoreductase
Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Tetratricopeptide repeat protein 7 N-terminal
Signal recognition particle subunit SRP54
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
Mitochondrial proton/calcium exchanger protein
Required for binding to the neuron-restrictive silencer element
Necessary for poly U RNA-binding and snRNA export
Phosphorylated adapter RNA export protein
Phosphorylated adapter RNA export protein RNA-binding
Polypeptide N-acetylgalactosaminyltransferase 10
Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum
Interaction with the K-D-E-L motif on target proteins
In isoform 2, isoform 5, isoform 7 and isoform 8.
In isoform 3, isoform 5, isoform 6 and isoform 8.
In isoform 4, isoform 6, isoform 7 and isoform 8.
Proline-rich nuclear receptor coactivator 1
Calcium/calmodulin-dependent protein kinase type 1G
Alpha-aminoadipic semialdehyde synthase, mitochondrial
Guanine nucleotide exchange factor C9orf72 homolog
Required for the homodimerization of the C9orf72-SMCR8 complex
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Apolipoprotein L domain-containing protein 1
CDGSH iron-sulfur domain-containing protein 1
Schiff-base intermediate with pyridoxal 5'-phosphate
Meiosis-specific nuclear structural protein 1
Binding site for the uncoating ATPase, involved in lattice disassembly
Involved in binding clathrin light chain
U3 small nucleolar RNA-associated protein 20 C-terminal
U3 small nucleolar RNA-associated protein 20 N-terminal
Constitutively activates downstream transcription factor function.
Fails to activate downstream transcription factor function.
Low-density lipoprotein receptor-related protein 2
PxLPxI/L motif 1; mediates interaction with ANKRA2
PxLPxI/L motif 2; mediates interaction with ANKRA2
Reduced interaction with ARH and dynein.
Voltage-dependent calcium channel gamma-like subunit
Abolishes regulation of calcium mobilization.
Highly reduces thioredoxin reductase activity.
Thioredoxin reductase-like selenoprotein T
Aryl-hydrocarbon-interacting protein-like 1
Involved in condensin complex recruitment
N-linked (GlcNAc...) (keratan sulfate) asparagine
Abolishes interaction with APP and impairs the function in DNA repair.
Amyloid beta precursor protein binding family B member 1
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
Loss of zinc export across plasma membrane and no effect on localization to the plasma membrane; when associated with A-254.
Loss of zinc export across plasma membrane and no effect on localization to the plasma membrane; when associated with A-43.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
Voltage-dependent L-type calcium channel subunit beta-2
Leucine-rich PPR motif-containing protein, mitochondrial
Sperm microtubule associated protein 2-like
Nuclear-interacting partner of ALK/Rsm1-like C-terminal
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Rad21/Rec8-like protein C-terminal eukaryotic
Transcription elongation factor, mitochondrial
Collagen triple helix repeat-containing protein 1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Myb/SANT-like DNA-binding domain-containing protein
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Induces a strong decrease in activity; loss of function; when associated with A-484 and A-525.
Loss of enzyme activity due to absence of interaction between UDP moiety and UDP-GalNAC.
Loss of enzyme activity; when associated with A-444 and A-484.
Loss of enzyme activity; when associated with A-444 and A-525.
Polypeptide N-acetylgalactosaminyltransferase 1
Polypeptide N-acetylgalactosaminyltransferase 1 soluble form
Loss of enzymatic activity; when associated with T-636 change in subcellular location, loss of PMA-induced down-regulation and loss of enzymatic activity.
Loss of enzymatic activity; when associated with T-643 change in subcellular location, loss of PMA-induced down-regulation and loss of enzymatic activity.
Required for interaction with F-actin-capping protein subunit alpha (CAPZA1 or CAPZA2 or CAPZA3)
Sufficient for interaction with WASHC3, WASHC4 and WASHC5; required for interaction with WASHC1
Glycylpeptide N-tetradecanoyltransferase C-terminal
Glycylpeptide N-tetradecanoyltransferase N-terminal
Sodium/potassium-transporting ATPase subunit beta-3
Phosphothreonine; by ROCK1, ROCK2, CDC42BP, ZIPK/DAPK3 and RAF1
Protein phosphatase 1 regulatory subunit 12A
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Ribose-phosphate pyrophosphokinase N-terminal
Lysosomal-associated transmembrane protein 4A
Post-GPI attachment to proteins factor 3
Calcium/calmodulin-dependent protein kinase type 1
Loss of activation by CaMKK1 and CaMKK2.
Partially excluded from the nucleus; when associated with 319-AQA-321.
Retention in the nucleus. Partially excluded from the nucleus; when associated with 263-AA-264.
ATP synthase-coupling factor 6, mitochondrial
Protein phosphatase 1 regulatory subunit 7
U2A'/phosphoprotein 32 family A C-terminal
Iron-sulfur clusters transporter ABCB7, mitochondrial
Malonyl-CoA decarboxylase, mitochondrial
SAM-dependent methyltransferase TRM5/TYW2-type
tRNA wybutosine-synthesizing protein 2 homolog
Diphosphoinositol polyphosphate phosphohydrolase 1
Electrogenic sodium bicarbonate cotransporter 1
No effect on N-glycosylation. Complete loss of N-glycosylation without effect on transporter basic function; when associated with Q-597 and Q-617.
Reduces the extent of N-glycosylation. Complete loss of N-glycosylation without effect on transporter basic function; when associated with Q-592 and Q-597.
Reduces the extent of N-glycosylation. Complete loss of N-glycosylation without effect on transporter basic function; when associated with Q-592 and Q-617.
Ubiquitin-like domain-containing CTD phosphatase 1
Disintegrin and metalloproteinase domain-containing protein 17
Secretory calcium-binding phosphoprotein proline-glutamine-rich protein 1
Pseudouridine synthase I TruA alpha/beta
Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction
Decreased nuclear import with localization in the nucleus but also in the cytoplasm
Repression domain; contains 3 sumoylation motifs and massively decrease transcription activity
Increased microtubule stability but no effect on neurite length; when associated with A-62.
Increased microtubule stability but no effect on neurite length; when associated with A-73.
Partial loss of phosphorylation. Complete loss of phosphorylation by MAPK8, increased microtubule solubility, and reduced neurite length; when associated with A-62.
Partial loss of phosphorylation. Complete loss of phosphorylation by MAPK8, increased microtubule solubility, and reduced neurite length; when associated with A-73.
5'-AMP-activated protein kinase subunit beta-2
Interaction with NR3C1 decreased when missing
Interaction with NR3C1, homodimerization and transcriptional activation almost abolished when missing
Cyclin-D-binding Myb-like transcription factor 1
In isoform 1, isoform 2, isoform 3, isoform 5 and isoform 6.
DNA-directed RNA polymerase III subunit RPC5 C-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Reduces affinity for substrate 20-fold, and decreases affinity for the competitive inhibitor fructose 2,6-bisphosphate 500-fold.
Eukaryotic translation initiation factor 3 subunit D
Activator of Hsp90 ATPase AHSA1-like N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Impairs receptor-mediated endocytosis. Increases the stability of focal adhesion and decreases their turnover; when associated with F-384 and F-429.
Impairs receptor-mediated endocytosis. Increases the stability of focal adhesion and decreases their turnover; when associated with F-384 and F-445.
Impairs receptor-mediated endocytosis. Increases the stability of focal adhesion and decreases their turnover; when associated with F-429 and F-445.
Inhibits actin polymerization; when associated with A-368.
Inhibits actin polymerization; when associated with A-381.
Promotes reorganization of the actin cytoskeleton and cell motility; when associated with E-384 and E-429.
Promotes reorganization of the actin cytoskeleton and cell motility; when associated with E-384 and E-445.
Promotes reorganization of the actin cytoskeleton and cell motility; when associated with E-429 and E-445.
Ubiquitin carboxyl-terminal hydrolase 30
Cyclin-dependent kinase 5 activator 1, p25
Cyclin-dependent kinase 5 activator 1, p35
Decreased susceptibility to calpain cleavage.
Increased susceptibility to calpain cleavage.
Epithelial-stromal interaction protein 1
Heat shock protein 75 kDa, mitochondrial
Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion
Dominant negative mutant; abolishes ERG current.
Potassium voltage-gated channel subfamily H member 2
Amino acid transporter heavy chain SLC3A1
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Sodium-dependent neutral amino acid transporter B(0)AT3
Mediates interaction with the alpha subunit
Voltage-dependent L-type calcium channel subunit beta-3
Calcium/calmodulin-dependent protein kinase type 1B
Interaction with PxVP motif in substrates of the catalytic subunit
POU domain, class 4, transcription factor 3
Leucine-rich repeat-containing protein 66
SUMO-activating enzyme subunit 2 C-terminal
Ubiquitin/SUMO-activating enzyme ubiquitin-like
Beta-hairpin required for oligomerization
Glutamate receptor ionotropic, kainate 3
Zinc finger CCHC domain-containing protein 2
Myelin-associated neurite-outgrowth inhibitor
Disintegrin and metalloproteinase domain-containing protein 15
Arginine amide; in CCB peptide short form
CCB peptide long form without any modifications.
CCB peptide short form without any modifications.
Sulfated and phosphorylated CCB peptide long form.
Sulfated and phosphorylated CCB peptide short form.
Sulfated or phosphorylated CCB peptide long form.
Sulfated or phosphorylated CCB peptide short form.
Ubiquitin carboxyl-terminal hydrolase 11
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Primary cilium assembly protein FAM149B1
Abolishes phospholipase activity, but does not impair lipid binding.
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Required and sufficient for targeting to lysosomes and lamellar bodies
Linker for activation of T-cells family member 1
N-acetylmethionine; in peptidyl-prolyl cis-trans isomerase FKBP4; alternate
N-acetylthreonine; in peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; partial
Peptidyl-prolyl cis-trans isomerase FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed
Cytosolic arginine sensor for mTORC1 subunit 1
Peptide (Met-Gly) (interchain with G-Cter in ubiquitin)
Testis-specific protein 10-interacting protein
Dimeric form; when associated with E-349. Does not form the high-order complex with SHANK1; when associated with E-349. Does not change its interaction with STX12; when associated with E-349. Reduces localization to the spine; when associated with E-349. Affects dendritic spine structure; when associated with E-349. Decreases synaptic transmission; when associated with E-349. Does not affect glutamate receptors ratio; when associated with E-349.
Dimeric form; when associated with R-344. Does not form the high-order complex with SHANK1; when associated with R-344. Does not change its interaction with STX12; when associated with R-344. Reduces localization to the spine; when associated with R-344. Affects dendritic spine structure; when associated with R-344. Decreases synaptic transmission; when associated with R-344. Does not affect glutamate receptors ratio; when associated with R-344.
Disrupts binding to both GRM1 and SHANK3. Does not form the high-order complex with SHANK1.
Eliminates binding to both GRM1 and SHANK3.
Multiple coagulation factor deficiency protein 2 homolog
Cytoplasmic dynein 1 light intermediate chain 1
N-terminal EF-hand calcium-binding protein 1
Microphthalmia-associated transcription factor
14-3-3 protein gamma, N-terminally processed
N-acetylvaline; in 14-3-3 protein gamma, N-terminally processed
Important for dimerization and interaction with PSMF1
MHC class I-like antigen recognition-like
Essential for high affinity interaction with RPL23A
Microfibrillar-associated protein 3-like
Abolishes nuclear localization; when associated with A-231.
Abolishes nuclear localization; when associated with A-233.
Fails to enhance GH-induced membrane ruffling; when associated with F-439.
Fails to enhance GH-induced membrane ruffling; when associated with F-494.
Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation)
Phosphoserine; by MAPK1 or MAPK3; in vitro
Phosphotyrosine; by JAK1, JAK2 and PDGFR
Reduces in vitro phosphorylation by MAPK1 and/or MAPK3.
Reduces interaction with JAK2 and abolishes JAK2 kinase activity; reduces GH-stimulated cell motility; abolishes interaction with PDGFRA.
Reduces phosphorylation by JAK1 and JAK2.
Reduces phosphorylation by JAK1, JAK2 and PDGFRA.
Mothers against decapentaplegic homolog 9
Transcription initiation factor TFIID subunit 9B
Isovaleryl-CoA dehydrogenase, mitochondrial
ATP synthase subunit C lysine N-methyltransferase
Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recycling
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Basic leucine zipper transcriptional factor ATF-like 3
Store-operated calcium entry regulator STIMATE
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Vacuolar protein-sorting-associated protein 25
ATP-binding cassette sub-family C member 3
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Ethanolamine-phosphate cytidylyltransferase
Zinc finger and BTB domain-containing protein 18
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Abolishes association with the Golgi apparatus.
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Abolishes cleavage by caspase-3 and subsequent induction of apoptosis.
Abolishes palmitoylation. Impairs interaction with DAPK1. No effect on location on lipid rafts.
No change in secretion; when associated with S-297.
No change in secretion; when associated with T-186.
GDP-fucose protein O-fucosyltransferase 1
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure
Necessary for nuclear and nucleolar caps localizations
Required for recruitment to cytoplasmic stress granules
Voltage-gated potassium channel subunit beta-3
Dolichol-phosphate mannosyltransferase subunit 3
Does not affect phosphorylation by MAPKAPK2.
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
NAD-dependent protein deacetylase sirtuin-7
Rate of phosphorylation by an insect Pink1 is increased.
Rate of phosphorylation by an insect Pink1 is slightly decreased.
Rate of phosphorylation by an insect Pink1 is very slightly increased.
Armadillo repeat-containing X-linked protein 3
Sodium-dependent neutral amino acid transporter SLC6A17
BoNT/E not taken up by mouse SV2A/SV2B knockout neurons, decreased uptake of BoNT/A; SV2A apparent molecular weight decreases. No change in uptake of BoNT/D.
N-linked (HexNAc...) asparagine; alternate
No change in uptake of BoNT/D or BoNT/E.
No change in uptake of BoNT/E or BoNT/A by mouse SV2A/SV2B knockout neurons; SV2A apparent molecular weight decreases. No change in uptake of BoNT/E; when associated with Q-498. No change in uptake of BoNT/D.
No change in uptake of BoNT/E or C.botulinum neurotoxin type A (BoNT/A, botA) by mouse SV2A/SV2B knockout neurons; SV2A apparent molecular weight decreases. No change in uptake of BoNT/E; when associated with Q-548. No change in uptake of BoNT/D.
No change in uptake of C.botulinum neurotoxin type D (BoNT/D, botD) or C.botulinum neurotoxin type E (BoNT/E).
Restores apparent molecular weight to wild-type, does not restore uptake of BoNT/E.
Coiled-coil domain-containing glutamate-rich protein 1
50% loss of zinc binding and loss of nucleolar localization; when associated with A-29; A-31 and A-35.
50% loss of zinc binding and loss of nucleolar localization; when associated with A-29; A-31 and A-38.
50% loss of zinc binding and loss of nucleolar localization; when associated with A-29; A-35 and A-38.
50% loss of zinc binding and loss of nucleolar localization; when associated with A-31; A-35 and A-38.
50% loss of zinc binding; when associated with Q-12; Q-14 and Q-16.
50% loss of zinc binding; when associated with Q-12; Q-14 and Q-24.
50% loss of zinc binding; when associated with Q-12; Q-16 and Q-24.
50% loss of zinc binding; when associated with Q-14; Q-16 and Q-24.
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Phenylalanine--tRNA ligase alpha subunit
Sodium- and chloride-dependent creatine transporter 1
Prolactin regulatory element-binding protein
Markedly reduced phosphorylation, 70% loss of CNP-dependent activity.
Markedly reduced phosphorylation, 80% loss of CNP-dependent activity.
No effect on phosphorylation, 30% loss of CNP-dependent activity.
Reduced phosphorylation, 30% loss of CNP-dependent activity.
Reduced phosphorylation, 50% loss of CNP-dependent activity.
Hydroxysteroid dehydrogenase-like protein 2
Interchain (between alpha and beta chains)
BMP/retinoic acid-inducible neural-specific protein 3
Mediator of RNA polymerase II transcription subunit 22
Tumor necrosis factor receptor superfamily member 11B
Insulin-like growth factor-binding protein 6
Involved in CX3CL1-, NRG1-, FGF1- and IGF1-binding
in ADMIDAS binding site and liganded-open conformation
Soluble interleukin-11 receptor subunit alpha
C-Jun-amino-terminal kinase-interacting protein 3
JNK-binding domain (JBD); essential for its function in axon elongation
Kinesin-binding domain (KBD); essential for its function in axon elongation
Leucine zipper-like domain (LZ); essential for its function in axon elongation
Coiled-coil SMC6 And NSE5 INteracting (CANIN)
Ubiquitin carboxyl-terminal hydrolase 19
Ankyrin repeat domain-containing protein 1
Pyroglutamylated RF-amide peptide receptor
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
Ankyrin repeat and BTB/POZ domain-containing protein 1
Coiled-coil domain-containing protein 172
Putative divalent cation/proton antiporter TMEM165
Thioredoxin domain-containing protein 15
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Carnitine O-palmitoyltransferase 2, mitochondrial
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Translation initiation factor 3 N-terminal
Nonsense-mediated mRNA decay factor SMG9
Cytochrome c oxidase subunit 5B, mitochondrial
N-acetylthreonine; in WD repeat-containing protein 61, N-terminally processed
Superkiller complex protein 8, N-terminally processed
Translation initiation factor beta propellor-like
Sodium-dependent phosphate transporter 2
Proto-oncogene tyrosine-protein kinase LCK
Ral GTPase-activating protein subunit alpha-1
Probable inactive tRNA-specific adenosine deaminase-like protein 3
Vacuolar protein sorting-associated protein 29
CLK4-associating serine/arginine rich protein
Phosphoserine; by PKC/PRKCG and PKC/PRKCD
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
Alters interaction with COPB1 but not with SEC24C.
Necessary and sufficient for localization to autophagosome
Prevents phosphorylation by ABL1 and impairs transport from the endoplasmic reticulum to the endoplasmic reticulum-Golgi intermediate compartment.
Required for interaction with COPB1, TMED9 and TMED10
Eukaryotic translation initiation factor 5B
Glycoside hydrolase family 31 N-terminal
Protein disulfide-isomerase-like protein of the testis
Cytochrome c oxidase subunit 8A, mitochondrial
Growth hormone-inducible transmembrane protein
Interaction with the other subunit in the homodimer
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Dimethylaniline monooxygenase [N-oxide-forming] 4
Mitogen-activated protein kinase kinase kinase 7
Signal transducer and activator of transcription 5A
Aryl hydrocarbon receptor nuclear translocator 2
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Sufficient for self-association and interaction with HD
RecQ mediated genome instability protein 1-like N-terminal helical
Required for interaction with TESK1 and ILK
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Increases the C23:C24 hydroxylation ratio from 0.01 to 0.08.
Increases the C23:C24 hydroxylation ratio from 0.01 to 0.12.
Increases the C23:C24 hydroxylation ratio from 0.01 to 0.13.
Increases the C23:C24 hydroxylation ratio from 0.01 to 0.15.
Increases the C23:C24 hydroxylation ratio from 0.01 to 0.16.
Increases the C23:C24 hydroxylation ratio from 0.01 to 0.19.
Uso1/p115-like vesicle tethering protein C-terminal
Vesicle tethering protein Uso1/P115-like head
Glycine amidinotransferase, mitochondrial
Loss of nuclear localization and loss of apoptosis induction.
Required for interaction with NMDA receptors
N-acetylserine; in Prothymosin alpha, N-terminally processed
Prothymosin alpha, N-terminally processed
Distal membrane-arm assembly complex protein 2
Death effector domain-containing protein
Leucine-rich repeat-containing protein 39
Developmental pluripotency-associated protein 3
Platelet-derived growth factor D, latent form
Platelet-derived growth factor D, receptor-binding form
Origin recognition complex subunit 5 C-terminal
ATP-sensitive inward rectifier potassium channel 8
Phosphoserine; by autocatalysis, PKA, PKC/PRKCZ and RPS6KA1
Phosphothreonine; by ATM and autocatalysis
Pleckstrin homology domain-containing family H member 3
Zinc finger and BTB domain-containing protein 42
Decreases phosphorylation by MAPK1 and MAPK3.
Eukaryotic translation initiation factor 4E-binding protein 1
Phosphoserine; by DYRK2, MAPK1, MAPK3 and MTOR
60S ribosome subunit biogenesis protein NIP7 homolog
Arginine vasopressin-induced protein 1/transcriptional and immune response regulator
Ig-like V-type domain-containing protein FAM187A
Leucine zipper transcription factor-like protein 1
Glutathione-specific gamma-glutamylcyclotransferase 1
Platelet-derived growth factor receptor-like protein
Transcription termination factor 3, mitochondrial
Essential for mediating its function in dendritic development; may contribute to neuronal-specific targeting
ATP-sensitive inward rectifier potassium channel 14
Proline-, glutamic acid- and leucine-rich protein 1
Required for modulation of ESR1 transcriptional activity
Resistance to inhibitors of cholinesterase protein 3 N-terminal
Required for IL4-induced gene expression
Required for IRS1 activation and IL4-induced cell growth
Increased localization to Golgi apparatus. Has no effect on cell migration.
2'-5'-oligoadenylate synthase-like protein 1
RCC1 and BTB domain-containing protein 2
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Epithelial splicing regulatory protein 1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Is directly targeted by the spider protoxin-II
Sodium channel protein type 9 subunit alpha
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Staphylococcal nuclease domain-containing protein 1
Nuclear receptor-interacting protein 1 repression
L-serine dehydratase/L-threonine deaminase
U3 small nucleolar ribonucleoprotein protein IMP4
CUB and zona pellucida-like domain-containing protein 1
Protein phosphatase 1 regulatory subunit 14A
Hydroxyacylglutathione hydrolase, mitochondrial
Coiled-coil domain-containing protein 181
Corticotropin-releasing factor receptor 2
C-tail signal; necessary for mitochondrion outer membrane localization and integration in the TOM complex
Import sequence; necessary for mitochondrion outer membrane localization and integration in the TOM complex
Inhibits localization to the mitochondrion outer membrane.
Mitochondrial import receptor subunit TOM22 homolog
TMD; necessary for mitochondrion outer membrane localization and integration in the TOM complex
Abrogates CRM1-independent nuclear export.
Double-stranded RNA-binding protein Staufen homolog 2
Protein phosphatase 1 regulatory subunit 21 N-terminal
Tumor-associated calcium signal transducer 2
Glycosyltransferase subfamily 4-like N-terminal
Reduced affinity for DCC. Strongly reduced affinity for DCC; when associated with A-117.
Reduced affinity for DCC. Strongly reduced affinity for DCC; when associated with A-123.
EGF domain-specific O-linked N-acetylglucosamine transferase
Complex I assembly factor ACAD9, mitochondrial
Spermatogenesis-associated serine-rich protein 1
Intercalates between bases and promotes DNA bending
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Transcription factor IIIC 90kDa subunit N-terminal
Transcription factor IIIC putative zinc-finger
60 kDa heat shock protein, mitochondrial
Phosphatidylinositol 3-kinase regulatory subunit gamma
Clathrin/coatomer adaptor adaptin-like N-terminal
Coatomer gamma subunit appendage Ig-like subdomain
15% of wild-type lysophospholipase D activity.
20% of wild-type lysophospholipase D activity.
Abolishes secretion. Strongly reduced lysophospholipase activity.
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Impaired secretion. No effect on lysophospholipase activity.
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)
Interchain (with C-46 or C-53); in multimeric form
Receptor-type tyrosine-protein phosphatase-like N
Sufficient for dimerization of proICA512
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Glycine cleavage system H protein, mitochondrial
2-oxoadipate dehydrogenase complex component E1
Probable inactive ribonuclease-like protein 12
TATA box-binding protein-associated factor RNA polymerase I subunit A
Nuclear receptor subfamily 1 group I member 3
BH3-interacting domain death agonist p11
BH3-interacting domain death agonist p13
BH3-interacting domain death agonist p15
Glutamate--cysteine ligase catalytic subunit
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
Required for glycosyltransferase activity
Receptor-type tyrosine-protein phosphatase alpha
Loss of GTPase activity. No effect on oligomerization.
Required for interaction with GRIP1, GRIP2 and PICK1
Involved in ceramide and phosphatidylcholine binding
Voltage-dependent anion-selective channel protein 2
Calcium-activated potassium channel subunit beta-1
Gamma-aminobutyric acid receptor-associated protein
Cilia- and flagella-associated protein 206
Leucine zipper putative tumor suppressor 1
Cyclic nucleotide-gated olfactory channel
Abolishes interaction with TJP1; when associated with Q-952.
Abolishes interaction with TJP1; when associated with Q-954.
Abolishes interaction with TJP1; when associated with Q-964.
Abolishes interaction with TJP1; when associated with Q-966.
Serine/threonine-protein kinase MRCK beta
Gamma-glutamylcyclotransferase AIG2-like
Damage-control phosphatase ARMT1-like metal-binding
Sodium-dependent neutral amino acid transporter B(0)AT2
Tubulointerstitial nephritis antigen-like
Abolishes interaction with TTGN1 and EGFR.
Inhibits endocytosis by AP-2; no effect on membrane association of AP-2.
V-type proton ATPase subunit B, brain isoform
Meiosis-specific with OB domain-containing protein
Transmembrane emp24 domain-containing protein 5
Mediates head to head self-assembly of N-terminal ends
Required for pH-induced assembly of C-terminal ends into antiparallel tetramers
Spermatid-specific linker histone H1-like protein
Phorbol-12-myristate-13-acetate-induced protein 1
Phosphotyrosine; by PKMYT1, WEE1, WEE2 and PKC/PRKCD
Amiloride-sensitive sodium channel subunit beta
Loss of kinase activity and reduction in oligodendrocyte process extension and myelin membrane formation.
Angiotensin-converting enzyme, soluble form
LHFPL tetraspan subfamily member 6 protein
Actin, aortic smooth muscle, intermediate form
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Superoxide dismutase [Mn], mitochondrial
Vacuolar protein sorting-associated protein 45
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Xin actin-binding repeat-containing protein 2
Mitochondrial tRNA methylthiotransferase CDK5RAP1
ATP synthase subunit alpha, mitochondrial
E3 ubiquitin-protein ligase Arkadia N-terminal
Microtubule-associated tumor suppressor 1 homolog
Abolishes phosphorylation and insulin-induced nuclear location, but no effect on insulin-induced 'S-727' phosphorylation of STAT3 nor on MAPK1 phosphorylation. Completely abolishes insulin-induced phosphorylation, nuclear location, nuclear translocation of MAPK1 and STAT3 and 'S-727' phosphorylation of STAT3 and MAPK1 phosphorylation; when associated with A-19.
Abolishes phosphorylation, insulin-stimulated interaction with phosphorylated MAPK1, MAPK1 nuclear translocation and activation, reduction of insulin-induced DNA binding of STAT3 but no effect on 'S-727' phosphorylation of STAT3. Completely abolishes phosphorylation, decreases insulin-induced DNA binding and impairs nuclear location of STAT3, inhibits insulin-induced 'S-727' phosphorylation of STAT3, and eliminates binding to RASA1, SRC and NCK1; when associated with A-27.
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Required for homotrimerization and induction of pyroptosomes
Major determinant of CYP1B1 17beta-estradiol hydroxylation regiospecificity
Shifts the 4OHE2:2OHE2 hydroxylation ratio from 0.38 to 1.8. Has the 4OH-hydroxylation specificity of the human enzyme.
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Coiled-coil domain-containing protein 91
BAG-similar domain, required and sufficient for interaction with UBL4A
Sufficient for the delivery of client proteins to the endoplasmic reticulum
Cyclic AMP-responsive element-binding protein 3-like protein 3
Processed cyclic AMP-responsive element-binding protein 3-like protein 3
Cleavage; by thrombin; to produce active factor XIII-A
Adaptin ear-binding coat-associated protein 1
Solute carrier family 52, riboflavin transporter, member 2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Does not affect Vmax for phenylalanine. Increases KM for phenylalanine.
Does not affect Vmax for phenylalaninet. Increases KM for phenylalanine.
Shifts substrate specificity from tyrosine to phenylalanine.
Differentially expressed in FDCP 8 homolog
Reduces catalytic activity about 100-fold.
Sodium- and chloride-dependent glycine transporter 1
INO80 complex subunit B-like conserved region
Tartrate-resistant acid phosphatase type 5
Alpha/beta hydrolase domain-containing protein 17C
Signal for sorting from recycling endosomes; interaction with ACAP1
Increased localization to the plasma membrane.
Abolishes localization at trans-Golgi network (TGN) and affects the integrity of the TGN. Inhibits retrograde trafficking of M6PR-associated vesicles.
Hepatitis A virus cellular receptor 1 homolog
Loss of phosphorylation, no effect on DNA-binding.
Leucine-rich repeat transmembrane neuronal protein 4
Di-leucine internalization motif; mediates targeting to late endosome and lysosome membranes
IQ motif and SEC7 domain-containing protein 3
Pre-mRNA processing factor 4 (PRP4)-like
Formamidopyrimidine-DNA glycosylase catalytic
Splicing factor, suppressor of white-apricot homolog
Tumor necrosis factor ligand superfamily member 15
Phosphoserine; by autocatalysis and TRPM7
GPI ethanolamine phosphate transferase 1 C-terminal
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
Intron-binding protein aquarius N-terminal
Trimeric intracellular cation channel type A
Implicated in catechol agonist binding and receptor activation
2-iminobutanoate/2-iminopropanoate deaminase
Oxidized low-density lipoprotein receptor 1
Oxidized low-density lipoprotein receptor 1, soluble form
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Presenilin-associated rhomboid-like protein, mitochondrial
Coiled-coil domain-containing protein 153
Katanin p60 ATPase-containing subunit A1
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Loss of aldehyde dehydrogenase activity.
Loss of formyltetrahydrofolate dehydrogenase activity. Loss of formyltetrahydrofolate hydrolase activity. No effect on aldehyde dehydrogenase activity.
Loss of formyltetrahydrofolate dehydrogenase activity. No effect on formyltetrahydrofolate hydrolase activity. No effect on NADP binding. No effect on homotetramerization.
Loss of phosphopantetheinylation. Loss of formyltetrahydrofolate dehydrogenase activity. No effect on hydrolase and aldehyde dehydrogenase activities in vitro.
Constitutive interaction with p115/USO1; under mitotic as well as interphase conditions.
Does not affect interaction with p115/USO1.
Impairs interaction with GORASP1/GRASP65.
Phosphomimetic mutant that strongly reduces interaction with p115/USO1.
Strongly impairs interaction with GORASP1/GRASP65.
Narpin; mediates binding with FGFR1 and has antidepressant-like activity
Translation initiation factor eIF-2B subunit gamma
Decreases phosphorylation-dependent actin binding.
Decreases strongly phosphorylation-dependent actin binding.
Does not decrease phosphorylation-dependent actin binding.
DNA damage-inducible transcript 4 protein
AID/alpha-interaction domain; mediates interaction with the beta subunit
Important for interaction with STAC1, STAC2 and STAC3
Important for localization in at the junctional membrane
Voltage-dependent L-type calcium channel subunit alpha-1C
Abolishes H(+)-coupled sialic acid transporter activity.
Decreases H(+)-coupled sialic acid transporter activity; when associated with C-171.
Decreases H(+)-coupled sialic acid transporter activity; when associated with C-175.
Decreases protein levels and alters subcellular localization.
Decreases the affinity and transport rate for D-glucuronate. Does not affect H(+)-coupled sialic acid transporter activity.
Markedly decreases H(+)-coupled sialic acid transporter activity.
Targeted to plasma membrane; sialic acid uptake strongly activated at acidic pH.
Interchain (with C-608 or C-609 in GP1BA)
Cytoplasmic polyadenylation element-binding protein 1
Important for the positionning of RRM1 relative to RRM2
Necessary for stress granule assembly and correct localization in dcp1 bodies
Aspartate dehydrogenase domain-containing protein
Aspartate/homoserine dehydrogenase NAD-binding
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
YbaK/aminoacyl-tRNA synthetase-associated
Abolishes F-actin binding and the inhibitory function on Arp2/3 complex-mediated actin nucleation, impairs lipid vesicle interaction, no effect on Arp2/3 complex association.
Abolishes association with Arp2/3 complex and the inhibitory function on Arp2/3 complex-mediated actin nucleation.
Abolishes interaction with other proteins, but not with itself.
Decreased lipid membrane binding, but no effect on peptide ligand recognition.
Aspartate beta-hydroxylase domain-containing protein 2
Platelet endothelial cell adhesion molecule
Ribosome biogenesis regulatory protein homolog
Zinc finger CCHC-type and RNA-binding motif-containing protein 1
Decreases interaction with KIF1A. Inhibits neuronal dense core vesicles mobility.
Increases interaction with KIF1A. Abolishes neuronal dense core vesicles mobility inhibition.
V-type proton ATPase 116 kDa subunit a 1
Glycoside hydrolase family 65 central catalytic
in ADMIDAS binding site and unliganded-closed conformation
Neuron-specific calcium-binding protein hippocalcin
Ubiquitin carboxyl-terminal hydrolase BAP1
Myelin transcription factor 1-like protein
Translation initiation factor eIF-2B subunit alpha
Microtubule-associated protein RP/EB family member 1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Transcription initiation factor IIA alpha chain
Transcription initiation factor IIA beta chain
Transcription initiation factor IIA subunit 1
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Dipeptidyl peptidase 1 exclusion domain chain
Acyl-CoA synthetase short-chain family member 3, mitochondrial
Necessary for PINK1-dependent localization to mitochondria
Constitutively active. Increases PAK1 and LIMK1 phosphorylation and NR3C2 nuclear localization in podocytes. In hippocampal neurons, increases the amount of dendritic protrusions and decreases the number of normal spines and synapses.
Constitutively active. Interacts with PPP5C.
Dominant negative. Reduces NMDA receptor-mediated synaptic currents.
Polybasic region; required for nuclear import
Ras-related C3 botulinum toxin substrate 1
Anaphase-promoting complex subunit 1 C-terminal
Anaphase-promoting complex subunit 1 middle
Phosphoserine; by RPS6KA1, RPS6KA3, DAPK1 and PASK
Sodium channel protein type 10 subunit alpha
Heterogeneous nuclear ribonucleoprotein D-like
Fibrinogen alpha/beta/gamma chain coiled coil
Receptor-type tyrosine-protein phosphatase zeta
DXXLL motif involved in the interaction with GGA1
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1
Required for efficient Golgi apparatus - endosome sorting
Required for interaction with GGA1 and GGA2
ST]-E-Y-X(3)-F motif 1; required for efficient microtubule binding and stabilization
ST]-E-Y-X(3)-F motif 2; required for efficient microtubule binding and stabilization
ST]-E-Y-X(3)-F motif 3; required for efficient microtubule binding and stabilization
ST]-E-Y-X(3)-F motif 4; required for efficient microtubule binding and stabilization
Interaction with ARHGAP33, ANKRA2, CDC42, PRDX3, RAD26L, RBBP6, RPS7 and TRIP4
TOX high mobility group box family member 2
Cytoplasmic dynein 1 light intermediate chain 2
Important for the stable binding to the membranes
Protein-S-isoprenylcysteine O-methyltransferase
Decreased interaction with GDP-bound RAN. No effect on interaction with nucleoporins. No effect on proteins nuclear import.
Loss of homodimerization. Decreased interaction with GDP-bound RAN. Decreased interaction with nucleoporins. Decreased localization to the nuclear pore complex.
Loss of interaction with GDP-bound RAN. Loss of GDP-bound RAN nuclear import.
Loss of interaction with GDP-bound RAN. No effect on interaction with nucleoporins. Decreased proteins nuclear import.
Loss of interaction with GDP-bound RAN. No effect on interaction with nucleoporins. Loss of GDP-bound RAN and other proteins nuclear import.
Loss of interaction with GDP-bound RAN. No effect on interaction with nucleoporins. Loss of proteins nuclear import.
No effect on homodimerization. Decreased interaction with GDP-bound RAN. Loss of interaction with nucleoporins and localization to the nuclear pore complex.
No effect on homodimerization. Loss of interaction with GDP-bound RAN. Decreased interaction with nucleoporins and localization to the nuclear pore complex.
No effect on interaction with GDP-bound RAN. Decreased interaction with nucleoporins. Decreased localization to the nuclear pore complex. Decreased GDP-bound RAN and other proteins nuclear import.
No effect on interaction with GDP-bound RAN. Increases GDP-bound RAN nuclear import. Increased interaction with nucleoporins and localization to the nuclear pore complex. Inhibits the nuclear import of nuclear localization signal-containing proteins.
No effect on interaction with GDP-bound RAN. No effect on interaction with nucleoporins. No effect on proteins nuclear import.
General transcription factor IIH subunit 2
Volume-regulated anion channel subunit LRRC8E
Interaction with NCOA1, NCOA2, NCOA3 and KAT2B
Nuclear receptor subfamily 4 group A member 3
Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membrane
Reduces sensitivity to alterations in external pH.
Choline-phosphate cytidylyltransferase B
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Required for ubiquitin ligase activity and protection against ER stress-induced cell death
Cytosolic carboxypeptidase-like protein 5
Abolishes palmitoylation and weakens membrane association; when associated with A-240.
Abolishes palmitoylation and weakens membrane association; when associated with A-241.
Essential for pH-sensitivity of estrone 3-sulfate transport
Loss of pH-sensitivity of estrone 3-sulfate transport.
Solute carrier organic anion transporter family member 1A1
Calcium/calmodulin-dependent protein kinase type II subunit delta
In isoform Delta 5, isoform Delta 6 and isoform Delta 7.
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
Voltage-dependent calcium channel gamma-1 subunit
Loss of interaction with GNAI2 and GNAI3.
EF-hand calcium-binding domain-containing protein 4A
Pancreatic progenitor cell differentiation and proliferation factor
Phosphatidylinositol transfer protein beta isoform
Stabilizes the active site histidine for nucleophilic attack
Mas-related G-protein coupled receptor member B8
2 X 7 AA tandem repeats of [PT]-[AT]-A-[ENT]-[PT]-[PTS]-[AG]
Important for FDH activity and activation by fatty acids
CHRNA9-CHRNA10 receptor is 25-fold less potently inhibited by the alpha-conotoxin RgIA.
CHRNA9-CHRNA10 receptor is 300-fold less potently inhibited by the alpha-conotoxin RgIA.
Involved in the interaction with the conotoxin GeXXA
Neuronal acetylcholine receptor subunit alpha-10
Potassium voltage-gated channel subfamily G member 3
Guanine nucleotide-binding protein-like 1
Guanine nucleotide-binding protein subunit alpha-11
Arginine/serine-rich coiled-coil protein 2
Dyslexia-associated protein KIAA0319 homolog
Pancreas transcription factor 1 subunit alpha
Abolishes ubiquitin ligase activity; when associated with S-169 and C-182.
Abolishes ubiquitin ligase activity; when associated with S-169 and C-184.
Abolishes ubiquitin ligase activity; when associated with S-182 and S-184.
Actin filament-associated protein 1-like 1
Metallo-beta-lactamase domain-containing protein 1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
Moderate reduction of protein expression levels. Abolishes both prostaglandin D synthase and glutathione-conjugating activities.
Moderate reduction of protein expression levels. No significant effect on catalytic activities.
No significant effect on protein expression levels. Abolishes both prostaglandin D synthase and glutathione-conjugating activities.
No significant effect on protein expression levels. Abolishes prostaglandin D synthase and significantly reduces glutathione-conjugating activities.
Significant reduction of protein expression levels. Abolishes prostaglandin D synthase and significantly reduces glutathione-conjugating activities.
Significant reduction of protein expression levels. Moderately reduces prostaglandin D synthase activity.
Significant reduction of protein expression levels. Significantly reduces prostaglandin D synthase and moderately reduces glutathione-conjugating activities.
Important for metal ion-dependent interaction with integrin
Impairs translocation from the cytoplasm to the nucleus upon glucose stimulation.
High affinity immunoglobulin epsilon receptor subunit gamma
Acid sphingomyelinase-like phosphodiesterase
Acid sphingomyelinase-like phosphodiesterase 3a
Sphingomyelin phosphodiesterase C-terminal
Oxidative stress-responsive serine-rich protein 1
Abolishes phosphorylation by PKA and PKA-mediated down-regulation of enzyme activity.
Reduces phosphorylation by PKC and PKC-mediated inhibition.
Reduces phosphorylation by PKC, abolishes PKC-mediated inhibition.
Transmembrane protease serine 11G catalytic chain
Transmembrane protease serine 11G non-catalytic chain
Intraflagellar transport protein 22 homolog
Small ribosomal subunit protein uS2 C-terminal
Uncharacterized protein C12orf60 homolog
Abolishes interaction with KCNAB2 and strongly reduces cell surface expression. No effect phosphorylation in response to increased cAMP levels.
Alters voltage-sensitive channel opening.
Changes channel gating from a predominantly slow mode to a much more rapid mode.
Confers sensitivity to inhibition by tetraethylammonium (TEA).
Impairs N-glycosylation and abolishes expression at the cell surface.
Impairs protein folding. Loss of tetramerization.
Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin
Important for normal, slow channel gating
In paddle chimera; changes channel activation to less negative voltage values and renders the channel susceptible to inhibition by the spider toxin VsTx1.
Nearly abolishes interaction with CTTN; when associated with F-415. Strongly reduces channel activity.
Nearly abolishes interaction with CTTN; when associated with F-417.
No effect on N-glycosylation. Abolishes channel activity of the homotetramer, but retains channel activity in the presence of a beta subunit.
No effect on tetramerization. Alters voltage-sensitive channel opening.
Potassium voltage-gated channel subfamily A member 2
Strongly reduces cell surface expression. Abolishes phosphorylation in response to increased cAMP levels.
SNARE-complex protein Syntaxin-18 N-terminal
Voltage-dependent L-type calcium channel subunit beta-4
10-fold decrease in activity of the spider RTX-VII toxin.
12-fold decrease in activity of the spider RTX-VII toxin.
2-fold decrease in activity of the spider RTX-VII toxin.
20-fold decrease in activity of the spider RTX-VII toxin.
4.5-fold decrease in activity of the spider RTX-VII toxin.
5.5-fold decrease in activity of the spider RTX-VII toxin.
6-fold decrease in activity of the spider RTX-VII toxin.
Important residue that permits the spider RTX-VII toxin to inhibit fast inactivation of the channel
Increase in sensitivity to the scorpion toxin BMKM1.
Key residue that permits the spider beta/delta-theraphotoxin-Pre1a to inhibit fast inactivation of the channel
Sodium channel protein type 3 subunit alpha
Voltage-gated Na+ ion channel cytoplasmic
Beta-adaptin appendage C-terminal subdomain
Abolishes interaction with AP2B1; no effect on interaction with clathrin.
Abolishes interaction with CLTC; reduces interaction with AP2B1.
Almost abolishes phosphorylation; inhibits internalization of ADRB2; when associated with D-361.
Almost abolishes phosphorylation; inhibits internalization of ADRB2; when associated with D-383.
Greatly reduces interaction with MAPK10.
Inhibits internalization of EDNRA and EDNRB.
Promotes agonist-stimulated down-regulation of CHRM2 and CHRM1; no effect on internalization of CHRM2; when associated with R-107, R-108, R-207 and R-296.
Promotes agonist-stimulated down-regulation of CHRM2 and CHRM1; no effect on internalization of CHRM2; when associated with R-18, R-107, R-108 and R-207.
Promotes agonist-stimulated down-regulation of CHRM2 and CHRM1; no effect on internalization of CHRM2; when associated with R-18, R-107, R-108 and R-296.
Promotes agonist-stimulated down-regulation of CHRM2 and CHRM1; no effect on internalization of CHRM2; when associated with R-18, R-107, R-207 and R-296.
Promotes agonist-stimulated down-regulation of CHRM2 and CHRM1; no effect on internalization of CHRM2; when associated with R-18, R-108, R-207 and R-296.
Transient ubiquitination; no stable endocytic complexes with AGTR1; impaired in scaffolding-activated ERK1/2.
High mobility group nucleosome-binding domain-containing protein 5
Protein inscuteable homologue C-terminal
Protein inscuteable homologue LGN-binding
Serine/threonine-protein kinase 3 20kDa subunit
Serine/threonine-protein kinase 3 36kDa subunit
Splicing regulatory glutamine/lysine-rich protein 1
Decrease in the level of phosphorylation. Strong decrease in the level of phosphorylation; when associated with D-1392.
Leucine-rich repeat-containing protein 7
Strong decrease in the level of phosphorylation; when associated with D-1288.
No effect on oxidant-mediated disulfide bond formation nor on in vitro PKC-mediated phosphorylation. No effect on oxidant-mediated disulfide bond formation; when associated with G-4 or S-9.
No effect on oxidant-mediated disulfide bond formation nor on in vitro PKC-mediated phosphorylation. No effect on oxidant-mediated disulfide bond formation; when associated with S-3 or G-4.
No effect on oxidant-mediated disulfide bond formation nor on in vitro PKC-mediated phosphorylation. No effect on oxidant-mediated disulfide bond formation; when associated with S-3 or S-9.
No oxidant-mediated disulfide bond formation. No effect on in vitro PKC-mediated phosphorylation. No oxidant-mediated disulfide bond formation; when associated with S-3; G-4 and S-9.
Required to promote KDM1B demethylase activity toward histone H3K4me1 and H3K4me2
Transcription factor NF-E2 45 kDa subunit
Tubulin polymerization-promoting protein
Diphosphoinositol polyphosphate phosphohydrolase 2
Required for dimerization and maintaining endoplasmic reticulum morphology
Essential for heterodimerization with RXRA
Peroxisome proliferator-activated receptor alpha
Required for heterodimerization with RXRA
Myosin light chain 1/3, skeletal muscle isoform
Ubiquitin-conjugating enzyme E2 variant 2
Complement C1q tumor necrosis factor-related protein 5
Clathrin heavy chain linker domain-containing protein 1
Nuclear protein localization protein 4 homolog
Mas-related G-protein coupled receptor member E
Interchain (between alpha-2-2 and delta-2 chains)
Voltage-dependent calcium channel subunit alpha-2-2
Voltage-dependent calcium channel subunit alpha-2/delta-2
Voltage-dependent calcium channel subunit delta-2
Acyl-coenzyme A synthetase ACSM2, mitochondrial
Fibronectin type 3 and ankyrin repeat domains 1 protein
Interphotoreceptor matrix proteoglycan 1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Essential for binding to the MRN complex and for RPA focus formation on DNA damage
Required for interaction with LMO4, probably by making physical contact with LMO4
Required for interaction with LMO4, probably by stabilizing the interaction through RPPB8 dimerization
Flexible linker region involved in nuclear import of HSP70 proteins
Required for F-X-F-G repeats-nucleoporins recognition and nuclear import
Pyrimidine nucleoside phosphorylase C-terminal
PTB domain-containing engulfment adapter protein 1
Guanine nucleotide-binding protein G(q) subunit alpha
Beta-1,3-galactosyltransferase 2 N-terminal
Abolishes interaction with PPP1CA and PPP1CA inhibition.
Does not abolish interaction with PPP1CA and does not reduce PPP1CA inhibition.
Does not abolish interaction with PPP1CA and reduces a little PPP1CA inhibition.
Reduces interaction with PPP1CA and reduces strongly PPP1CA inhibition.
Serine/threonine-protein phosphatase 1 regulatory subunit 10
Glycylpeptide N-tetradecanoyltransferase 1
Lowers activity towards medium and long chain fatty acids. Increases activity towards short chain fatty acids.
Peroxisomal carnitine O-octanoyltransferase
Reduces activity by 80%. No effect on inhibition by malonyl-coenzyme A.
Important for interaction with transmembrane receptors
TYRO protein tyrosine kinase-binding protein
Double C2-like domain-containing protein alpha
KA1; binds the bulging loops of U6 snRNA but is dispensable for terminal uridylyltransferase activity
Speckle targeted PIP5K1A-regulated poly(A) polymerase
Important for allosteric inhibitor binding
Interaction with the endogenous ligand GLP-1
Ras association domain-containing protein 5
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
2-oxoglutarate dehydrogenase complex component E1
Loss of transcriptional repressor activity. Loss of interaction with TRIM28.
Required for transcriptional repression activity; probably mediates sequence-specific DNA-binding
Interchain (with C-1359 or C-1384 in LTBP1); in inactive form
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Zinc finger-containing ubiquitin peptidase 1
Nuclear envelope pore membrane protein POM 121
ABC-type uncharacterised transport system
Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2
Mediates end-to-end attachment of dimers
Required for self-association and induction of membrane tubulation
Voltage-dependent L-type calcium channel subunit alpha-1S
Proline-rich nuclear receptor coactivator 2
Loss of serine/threonine-protein kinase without affecting interaction with SPRED1.
In isoform 2, isoform 6, isoform 7 and isoform 8.
In isoform 4, isoform 5, isoform 7 and isoform 8.
Gypsy retrotransposon integrase-like protein 1
C-1-tetrahydrofolate synthase, cytoplasmic
Formyltetrahydrofolate synthetase domain
Methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase (D/C) domain
10-fold decrease in inhibition by the spider pi-theraphotoxin-Hm3a.
18-fold decrease in inhibition by the spider pi-theraphotoxin-Hm3a.
37-fold decrease in inbibition by the snake mambalgin-1 toxin. Very high decrease in inhibition by the snake mambalgin-2 toxin.
Complete loss in inhibition by 200 nM of the snake mambalgin-2 toxin.
Complete loss of inhibition by the spider Pi-hexatoxin-Hi1a, and by the snake mambalgin-2 toxin. Potentiated by the spider pi-theraphotoxin-Hm3a (at both pH 7.35 and 7.45) and inhibited at higher toxin concentration at pH 7.35. Complete loss in the shift of pH for both activation and desensitization by the spider venom psalmotoxin-1.
High decrease in inhibition by the snake mambalgin-2 toxin.
Important for interaction with the snake venom mambalgin-1 and mambalgin-2 toxins, probably binds to its residue L-53; Important for interaction with the spider venom Pi-hexatoxin-Hi1a and psalmotoxin-1
Important for interaction with the snake venom mambalgin-2
Important residue for interaction with the spider venom Pi-theraphotoxin-Hm3a, which can explain functional difference between ASIC1a and ASIC1b
Important residue in interaction with the spider venom Pi-theraphotoxin-Hm3a, which can explain functional difference between ASIC1a and ASIC1b
Involved in divalent cations permeability
Moderate decrease in inhibition by the snake mambalgin-2 toxin.
No change in the shift of pH for both activation and desensitization by the spider venom psalmotoxin-1.
No effect on channel activation and inactivation.
No effect. Increases desensitization rates; when associated with L-84 and M-85.
No effect. Increases desensitization rates; when associated with P-83 and L-84.
No effect. Increases desensitization rates; when associated with P-83 and M-85.
No significant decrease in inhibition by the spider pi-theraphotoxin-Hm3a.
Reduction of Ca(2+) block. Loss of Ca(2+) block; when associated with C-432.
Reduction of Ca(2+) block. Loss of Ca(2+) block; when associated with G-425.
Small decrease in inhibition by the snake mambalgin-2 toxin; RDQ-KQE mutant.
DNA-directed RNA polymerases I, II, and III subunit RPABC1
RNA polymerase subunit H/Rpb5 C-terminal
Spermatogenesis associated 6-like protein
Spermatogenesis-associated protein 6 N-terminal
Glycerophosphodiester phosphodiesterase 1
Strongly reduced activity; when associated with A-97.
Strongly reduced activity; when associated with A-99.
von Hippel-Lindau disease tumor suppressor
von Hippel-Lindau disease tumour suppressor alpha
von Hippel-Lindau disease tumour suppressor beta
Eukaryotic translation initiation factor 2 subunit 3, Y-linked
Important for binding to glycosaminoglycan chains
Receptor-type tyrosine-protein phosphatase S
Thioredoxin-related transmembrane protein 2
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Abolishes heme-binding but does not affect reductase activity.
Vasoactive intestinal polypeptide receptor 1
Potassium voltage-gated channel subfamily H member 8
Potassium voltage-gated channel subfamily KQT member 3
Platelet-activating factor acetylhydrolase IB subunit alpha1
Cilia- and flagella-associated protein 36
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Death domain-containing membrane protein NRADD
Pulmonary surfactant-associated protein B
TRAF-interacting protein with FHA domain-containing protein B
TATA element modulatory factor 1 TATA binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
IMS import disulfide relay-system CHCH-CHCH-like Cx9C
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For hydroxyacyl-coenzyme A dehydrogenase activity
Important for hydroxyacyl-coenzyme A dehydrogenase activity
Important for long-chain enoyl-CoA hydratase activity
Trifunctional enzyme subunit alpha, mitochondrial
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter C-terminal
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter N-terminal
CAP-Gly domain-containing linker protein 1
Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-309; A-311; A-313 and A-319.
Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-309; A-311; A-313 and A-320.
Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-309; A-311; A-319 and A-320.
Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-309; A-313; A-319 and A-320.
Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-311; A-313; A-319 and A-320.
Phosphomimetic mutant which exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-309; E-311; E-319 and E-320.
Phosphomimetic mutant which exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-309; E-313; E-319 and E-320.
Phosphomimetic mutant which exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-30; E-311; E-313 and E-320.
Phosphomimetic mutant which exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-311; E-313; E-319 and E-320.
Phosphomimetic mutant, exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-309; E-311; E-313 and E-319.
Cell adhesion molecule-related/down-regulated by oncogenes
Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with GAS1.
Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with PTCH1 or GAS1. The mutation protein has a shorted half-life compared to wild-type and may have an altered conformation resulting in destabilization.
Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with PTCH1. The mutation protein has a shorted half-life compared to wild-type and may have an altered conformation resulting in destabilization.
Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains very little residual activity even during overexpression and interacts with SHH, but does not interact with PTCH1, BOC, or GAS1.
Alpha/beta hydrolase domain-containing protein 17A
In isoform 2, isoform 4, isoform 5 and isoform 6.
Turns CAST from an inhibitor into a substrate.
Uncharacterized protein C11orf87 homolog
Uncharacterized protein C16orf46 homolog
RING-finger and WD40-associated ubiquitin-like domain (RAWUL); sufficient for interaction with BCOR and BCORL1
Required for the interaction with the KDM2B-SKP1 heterodimeric complex
Doublesex- and mab-3-related transcription factor C1/C2 C-terminal
Neuronal vesicle trafficking-associated protein 2
Confers inhibition of transferrin uptake comparable to Sh3gl3 upon overexpression.
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Lysosomal-associated transmembrane protein 4B
Loss of phosphorylation and strong reduction of activity.
Loss of phosphorylation; No inhibition of activity.
Phosphoserine; by PKB/AKT1, RPS6KA3 and SGK3
Mitochondrial import inner membrane translocase subunit Tim9
Strongly reduces binding to PtdIns(3,5)P2.
Interferon-related developmental regulator 1
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Polyribonucleotide 5'-hydroxyl-kinase Clp1
Serine/threonine-protein phosphatase 6 catalytic subunit
Mediates preference for acidic residues at subsite P1'
Predominantly occurs as a monomer, less than 10% occurs as dimer.
Meiotic recombination protein REC8 homolog
Suppression of tumorigenicity 18 protein
Isoaspartyl glycine isopeptide (Asn-Gly); alternate
Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
HCH Motif; seals regulatory zinc-binding pocket
Endoribonuclease Regnase 1/ZC3H12 C-terminal
Plasma membrane calcium-transporting ATPase 4
Ras-specific guanine nucleotide-releasing factor 2
Responsible of the affinity for farnesylated versus geranylgeranylated Ras
Ubiquitin carboxyl-terminal hydrolase CYLD
DNA-directed RNA polymerase subunit 2 hybrid-binding
Hepatoma-derived growth factor-related protein 3
Cation-transporting P-type ATPase C-terminal
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
Nuclear respiratory factor 1 NLS/DNA-binding dimerisation
Important for Na(+)-selective paracellular ion transport
Important for the formation of tight-junction strand-like structures
Secreted lymphocyte activation gene 3 protein
Important for homodimerization and interaction with FBXO7
Vacuolar protein sorting-associated protein 52 homolog
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Mannan-binding lectin serine protease 2 A chain
Mannan-binding lectin serine protease 2 B chain
Actin, cytoplasmic 1, N-terminally processed
N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed
Methyl-CpG binding and interaction with HDAC1
Required for affinity and specificity for 5-mCpG sequence
Required for formation of a 5-methylcytosine-binding pocket
Required to confer preferential recognition of cytosine over thymine
Required to discriminate between hemimethylated DNA versus symmetrically methylated DNA
Critical for hydrolysis GM2 gangliosides
Abolishes interaction with HOMER1 isoform 3.
Disrupts postsynaptic AMPA and NMDA receptor-mediated synaptic transmission as well as transsynaptic signaling and spine maturation.
Disrupts postsynaptic AMPA and NMDA receptor-mediated synaptic transmission as well as transsynaptic signaling and spine maturation. Disrupts axonal growth cone motility. Slightly increases interaction with SHARPIN and SPTAN1. No effect on localization.
Disrupts postsynaptic AMPA and NMDA receptor-mediated synaptic transmission as well as transsynaptic signaling and spine maturation. Slightly decreases interaction with SHARPIN and SPTAN1. No effect on localization.
Intramolecular interaction with the ANK repeats
SH3 and multiple ankyrin repeat domains protein 3
Slightly increases interaction with SHARPIN and SPTAN1. No effect on localization.
Strongly decreases interaction with ABI1.
Cysteine sulfenic acid (-SOH); alternate
Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin); alternate
Required for reduction of TSC22D1 protein stability
Translationally-controlled tumor protein
Interactions with ZNF403/GGNBP2 and OAZ3
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Synapse differentiation-inducing gene protein 1
Plasma membrane calcium-transporting ATPase 1
Required for basolateral membrane targeting
Chromodomain-helicase-DNA-binding protein 6
Required for DNA-dependent ATPase activity
Voltage-dependent calcium channel gamma-4 subunit
Potassium voltage-gated channel subfamily C member 4
Cytochrome b-c1 complex subunit 1, mitochondrial
CCR4-NOT transcription complex subunit 10
Spindle and centriole-associated protein 1
Isoamyl acetate-hydrolyzing esterase 1 homolog
UDP-glucose:glycoprotein glucosyltransferase 1
UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like
Causes dissociation from promyelocytic leukemia oncogenic bodies and increased blebbing-inducing potency; when associated with T-299.
Causes dissociation from promyelocytic leukemia oncogenic bodies and increased blebbing-inducing potency; when associated with T-300.
Loss of kinase activity, loss of PAWR-linked translocation into the cytoplasm; maintains nuclear localization but loss of localization to PML-NB.
Phosphoserine; by autocatalysis and DAPK1
Required for interaction with ATF4 but not with PAWR
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Amyloid-beta A4 precursor protein-binding family B member 3
Gamma-aminobutyric acid receptor subunit alpha-6
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Serine/threonine-protein kinase receptor R3
Sodium-dependent phosphate transport protein 2C
V-type proton ATPase 16 kDa proteolipid subunit c
Mediator of RNA polymerase II transcription subunit 20
Chromosome segregation in meiosis protein 3
X-ray repair cross-complementing protein 5
LKB1 serine/threonine kinase interacting protein 1 N-terminal
Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization
Switch II region; involved in RAP1GDS1 binding
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Decreased localization to the cell membrane. Decreased interaction with DLG3 and DLG4. No effect on glutamate-gated calcium ion channel activity.
No effect on localizationto the cell membrane. Decreased interaction with DLG3 and DLG4. No effect on glutamate-gated calcium ion channel activity.
Transient receptor potential cation channel subfamily M member 2
Heterogeneous nuclear ribonucleoprotein K
Induces partial mitochondria fragmentation; when overexpressed.
Part of a helix bundle domain, formed by helices from N-terminal and C-terminal regions
Killer cell lectin-like receptor subfamily B member 1
Mitochondrial import inner membrane translocase subunit Tim23
Transforming growth factor beta regulator 1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Guanine nucleotide-binding protein G(t) subunit alpha-3
Loss of activation by both bitter and sweet compounds due to disruption of interaction with taste receptors.
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Glutamate receptor-interacting protein 2
Abolishes microtubules binding when missing
Regulator of microtubule dynamics protein 2
Heterochromatin protein 1-binding protein 3
Probable proline--tRNA ligase, mitochondrial
Sodium-dependent neutral amino acid transporter B(0)AT1
Coordinates Mg2+ for interaction with Complement factor B Bb fragment
Interchain (between beta and alpha chains)
Major intrinsically disordered Notch2-binding receptor 1-like C-terminal
Essential for determining substrate specificity
Important for interaction with lipoprotein particles
Ras association domain-containing protein 6
Ventricular zone-expressed PH domain-containing protein homolog 1
DBC1/CARP1 catalytically inactive NUDIX hydrolase
ATP-dependent 6-phosphofructokinase, platelet type
Hereditary hemochromatosis protein homolog
Sigma non-opioid intracellular receptor 1
Targeting to endoplasmic reticulum-associated lipid droplets
Biogenesis of lysosome-related organelles complex-1 subunit 2
Lactosylceramide alpha-2,3-sialyltransferase
Serine protease inhibitor Kazal-type 1-like
Protein kinase C and casein kinase substrate in neurons 2 protein
Exocyst complex subunit Exo70 C-terminal
Glutamate--cysteine ligase regulatory subunit
Microtubule-associated proteins 1A/1B light chain 3B
Calcium/calmodulin-dependent protein kinase type II subunit beta
Mediates localization to plasma membrane and recycling endosomes
Non-canonical dileucine endocytic signal
Abolishes the inositol deacylation of GPI-anchor proteins.
Nucleolar pre-ribosomal-associated protein 1 C-terminal
Nucleolar pre-ribosomal-associated protein 1 N-terminal
Essential for stabilizing binding to COTL1
Polyunsaturated fatty acid 5-lipoxygenase
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
CREB-regulated transcription coactivator 2
Phosphoserine; by AMPK, MARK2, SIK1 and SIK2
Required for ubiquitination and degradation
Transducer of regulated CREB activity C-terminal
Transducer of regulated CREB activity N-terminal
Transducer of regulated CREB activity middle
14-3-3 protein beta/alpha, N-terminally processed
N-acetylthreonine; in 14-3-3 protein beta/alpha, N-terminally processed
von Willebrand factor A domain-containing protein 1
Decreases nuclear expression; when associated with A-104 and A-108.
Decreases nuclear expression; when associated with A-104 and A-109.
Decreases nuclear expression; when associated with A-108 and A-109.
Enhances nuclear expression; when associated with A-66 and A-67.
Enhances nuclear expression; when associated with A-66 and A-70.
Enhances nuclear expression; when associated with A-67 and A-70.
tRNA-uridine aminocarboxypropyltransferase 1
Gamma-aminobutyric acid receptor subunit alpha-1
Strongly decreases the affinity for GABA-dependent channel gating.
Nuclear receptor subfamily 2 group C member 2
Ral guanine nucleotide dissociation stimulator
Leucine-rich repeat-containing protein 41
Histone-arginine methyltransferase CARM1
Histone-arginine methyltransferase CARM1 N-terminal
May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate
Phytanoyl-CoA hydroxylase-interacting protein
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
V-type proton ATPase subunit S1/VOA1 transmembrane
Mitochondrial thiamine pyrophosphate carrier
Ankyrin repeat and SAM domain-containing protein 3
Interleukin-1 receptor accessory protein
Neuroblastoma suppressor of tumorigenicity 1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
ATPase family AAA domain-containing protein 3
Required for interaction with the inner surface of the mitochondrial outer membrane
LysM and putative peptidoglycan-binding domain-containing protein 3
BMP and activin membrane-bound inhibitor C-terminal
BMP and activin membrane-bound inhibitor N-terminal
BMP and activin membrane-bound inhibitor homolog
Has negligible effect on ATPase activity.
12-fold increase in affinity to the conotoxin BuIA (11-fold decrease in K(off)).
19-fold increase in affinity to the conotoxin BuIA (7-fold decrease in K(off)).
20-fold increase in affinity to the conotoxin BuIA (37-fold decrease in K(off)); 2-fold decrease in affinity to the conotoxin MII (no change in K(off), but 2-fold decrease in K(on)).
3-fold increase in affinity to the conotoxin BuIA (2-fold decrease in K(off)).
40-fold, 165-fold, and 300-fold decrease in inhibition of alpha-3-beta-2(L118Q) nAChR by alpha-conotoxins PnIA, GID and MII, respectively.
6.6-fold increase in affinity to the conotoxin BuIA (7-fold decrease in K(off)).
8.3-fold decrease in affinity to the conotoxin BuIA (4-fold increase in K(off) and a 2-fold decrease in K(on)).
9-fold increase in affinity to the conotoxin BuIA (15-fold decrease in K(off)).
Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA
Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding site
Key residue that may play an important stabilizing role for the interaction with alpha-conotoxins PnIA, GID and MII, allowing them to bind deep into the nAChR cleft
Neuronal acetylcholine receptor subunit beta-2
No change in inhibition of alpha-3-beta-2(F143A) nAChR by alpha-conotoxins PnIA, GID and MII. 12-fold and 6.6-fold increase in inhibition of alpha-4-beta-2(F143A) nAChR by alpha-conotoxins GID and MII, respectively, but no change in inhibition of the same receptor by alpha-conotoxin PnIA.
No change in inhibition of alpha-3-beta-2(V135G) nAChR by alpha-conotoxins GID and MII. 4.4-fold decrease in inhibition of alpha-3-beta-2(V135G) nAChR by alpha-conotoxins PnIA.
Very small decrease or no change in inhibition of alpha-3-beta-2(V135A) nAChR by alpha-conotoxins PnIA, GID and MII.
Required for complex formation with BFSP1 and BFSP2
10 X 4 AA tandem repeats of S-P-[RGMKC]-[RK]
Human immunodeficiency virus type I enhancer-binding protein 2 homolog
Ribosome biogenesis protein BMS1/TSR1 C-terminal
Does not affect PRAG1-CSK complex formation. Does not affect PRAG1-induced protein tyrosine phosphorylation.
Does not affect cytoplasmic localization.
Strong reduction of homodimerization; Does not affect PRAG1-CSK complex formation. Reduces CSK activation.
Na(+)/H(+) exchange regulatory cofactor NHE-RF2
Nitric oxide synthase-interacting protein zinc-finger
Electron transfer flavoprotein beta subunit lysine methyltransferase
Centrosomal protein Cep63/Deup1 N-terminal
Branched-chain-amino-acid aminotransferase, cytosolic
Translocon-associated protein subunit gamma
Killer cell lectin-like receptor subfamily E member 1
Phosphoserine; by PKA and PKB/AKT1 or PKB/AKT2
Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2
Fibronectin type III domain-containing protein 1
Protein phosphatase 1 regulatory subunit 3C
Completely abolishes catalytic activity.
Inhibits activity to about 20%. Insensitive to the inhibitors DEPC and PDMP.
Inhibits activity to about 30%. Decreased sensitivity to PDMP.
Inhibits activity to about 30%. Insensitive to the inhibitors DEPC and PDMP.
Leads to near complete loss of activity.
May play an important role in binding to the inhibitors DEPC and PDMP
No effect on activity. Decreased sensitivity to the inhibitor PDMP.
NLR family CARD domain-containing protein 4
ATP-binding cassette sub-family A member 2
Necessary for synergistic transcriptional activity with SMAD3
Loss of binding to STX1B and priming activity.
Loss of binding to STX1B and priming activity; when associated with P-1279 and E-1655.
Loss of binding to STX1B and priming activity; when associated with R-1190 and E-1655.
Loss of binding to STX1B and priming activity; when associated with R-1190 and P-1279.
Cholesterol side-chain cleavage enzyme, mitochondrial
Constitutively GTP-bound and constitutively active.
Loss of subcellular location to plasma and endosomal membrane.
Loss of subcellular location to plasma and endosomal membranes.
Loss of subcellular location to plasma membrane, decreased association with endomembranes.
Loss of subcellular location to plasma membrane.
Voltage-gated potassium channel subunit beta-1
Nuclear envelope integral membrane protein 2
Amiloride-sensitive sodium channel subunit gamma
Interferes with ubiquitination and increases amiloride-sensitive current and the number of active channels; when associated with R-13.
Interferes with ubiquitination and increases amiloride-sensitive current and the number of active channels; when associated with R-6.
Actin-related protein 2/3 complex subunit 1A
Solute carrier organic anion transporter family member 1B2
Adipocyte plasma membrane-associated protein
Cytochrome c oxidase subunit 8B, mitochondrial
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Transcriptional activator protein Pur-beta
DNA mismatch repair proteins mutS family
Spermatogenesis-defective protein 39 homolog
Dominant negative; secreted and retains ability to homooligomerize.
X-box-binding protein 1, cytoplasmic form
Lipolysis-stimulated lipoprotein receptor
Serine/threonine-protein phosphatase CPPED1
Neuronal vesicle trafficking-associated protein 1
No effect on protein expression and transport activity.
No effect on protein expression and transport activity. Reduced protein expression and loss of transport activity; when associated with S-306.
No effect on protein expression but reduced transport activity.
No effect on protein expression but reduced transport activity. Reduced protein expression and loss of transport activity; when associated with S-225 or S-520. No effect on protein expression and reduced transport activity; when associated with S-334.
No effect on protein expression but reduced transport activity. Reduced protein expression and loss of transport activity; when associated with S-225. No effect on protein expression and reduced transport activity; when associated with S-306.
No effect on protein expression but reduced transport activity. Reduced protein expression and loss of transport activity; when associated with S-306 or S-334.
Reduced protein expression and transport activity.
Sodium-dependent phosphate transport protein 2A
Hyaluronan-binding protein 2 27 kDa light chain
Hyaluronan-binding protein 2 27 kDa light chain alternate form
Hyaluronan-binding protein 2 50 kDa heavy chain
Hyaluronan-binding protein 2 50 kDa heavy chain alternate form
DDB1- and CUL4-associated factor 15 WD40 repeat-containing
Guanine nucleotide-binding protein subunit beta-5
Pleckstrin homology domain-containing family A member 4
Coatomer beta subunit appendage platform
MAP kinase-interacting serine/threonine-protein kinase 1
Ribosyldihydronicotinamide dehydrogenase [quinone]
Mothers against decapentaplegic homolog 4
Nuclear receptor subfamily 5 group A member 2
Phosphatidylinositol 4-kinase type 2-beta