G-protein coupled receptors family 1 profile
Partial retention in the endoplasmic reticulum.
Partial retention in the endoplasmic reticulum; still forms homodimers.
Required for interaction with prenylated RAB3A and VAMP2
Retention in the endoplasmic reticulum; does not form homodimers.
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Inosine-5'-monophosphate dehydrogenase 2
Mitochondrial 2-oxoglutarate/malate carrier protein
N6,N6,N6-trimethyllysine; by METTL21A; alternate
Receptor-type tyrosine-protein phosphatase zeta
Abolished tyrosine carboxypeptidase activity.
Involved in heparin-binding and antiangiogenic activity
Inactive 2'-5' oligoadenylate synthetase 1C
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
FYVE, RhoGEF and PH domain-containing protein 4
Large ribosomal subunit protein uL30 N-terminal eukaryotes
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Cartilage intermediate layer protein 2 C1
Cartilage intermediate layer protein 2 C2
Major facilitator superfamily (MFS) profile
Destabilizes heterodimerization with ARNT. Compromises the transcriptional repression activity of heterodimer ARNT:NPAS1.
Neuronal PAS domain-containing protein 1
Helical; Signal-anchor for type II membrane protein
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Essential for transport from endoplasmic reticulum to Golgi apparatus and interaction with SAR1A
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
Interaction with galactose moiety of substrate glycoprotein
Ligand-dependent nuclear receptor corepressor-like protein
Essential for specifying alpha-elongation versus initiation step of the polyglutamylase activity
Abolished protease activity and ability to desumoylate CGAS.
Dephospho-CoA kinase domain-containing protein
Pyrroline-5-carboxylate reductase 1, mitochondrial
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Mitochondrial translation release factor in rescue
Ciliary microtubule associated protein 1B
Transcription and mRNA export factor ENY2
Calcium/calmodulin-dependent protein kinase type 1G
Centromere/kinetochore protein zw10 homolog
Loss of interaction with DDB1 and strong decrease in TET2 monoubiquitination; when associated with A-1246.
Loss of interaction with DDB1 and strong decrease in TET2 monoubiquitination; when associated with A-1282.
Pterin-4-alpha-carbinolamine dehydratase
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3
Calcium-activated potassium channel subunit beta-1
Abolished DNA-binding without affecting binding to poly-ADP-ribose chains; when associated with A-254.
Abolished DNA-binding without affecting binding to poly-ADP-ribose chains; when associated with A-264.
Abolished binding to poly-ADP-ribose chains, preventing induction of parthanatos.
Apoptosis-inducing factor 1, mitochondrial
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Increases catalytic efficiency 30-fold. Increases affinity for NADH 20-fold.
Increases redox potential, reacts faster to NADH and forms two-fold longer-lived CTC.
Mitochondrial apoptosis-inducing factor C-terminal
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
Leucine-rich repeat and IQ domain-containing protein 4
Ubiquitin carboxyl-terminal hydrolase 17-like protein D
Abolishes inhibition of retrotransposition.
Selection and upkeep of intraepithelial T-cells protein 1
Beta-hairpin required for oligomerization
Abolishes interaction with PEX6 and ubiquitin. Impairs interaction with PEX5.
Mesencephalic astrocyte-derived neurotrophic factor
Abolishes interaction with MYD88 and IL-1-dependent activation of NF-kappa-B.
Abolishes interaction with PTPRD; when associates with 69-A--A-71 Significantly reduces synaptogenesis; when associates with 82-A--A-85.
Abolishes interaction with PTPRD; when associates with 82-A--A-85. Significantly reduces synaptogenesis; when associates with 82-A--A-85.
Interleukin-1 receptor accessory protein
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
N6-(2-hydroxyisobutyryl)lysine; alternate
N6-(beta-hydroxybutyryl)lysine; alternate
Symmetric dimethylarginine; by PRMT5; alternate
Helical; Anchor for type IV membrane protein
Complex I intermediate-associated protein 30, mitochondrial
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Neurotransmitter-gated ion-channel ligand-binding
Neurotransmitter-gated ion-channel transmembrane
Ubiquitin-conjugating enzyme E2 variant 2
AMP-dependent synthetase/ligase domain-containing protein
Long-chain fatty acid transport protein 5
Cysteine sulfonic acid (-SO3H); alternate
Histo-blood group ABO system transferase
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction
Decreased nuclear import with localization in the nucleus but also in the cytoplasm
Repression domain; contains 3 sumoylation motifs and massively decrease transcription activity
BMP and activin membrane-bound inhibitor homolog
120 kDa linear IgA disease antigen homolog
Necessary for interaction with DST and for the recruitment of DST to hemidesmosome
Proton acceptor; for glutaminase activity
Eukaryotic translation initiation factor 2 subunit 1
Unique cartilage matrix-associated protein
Unique cartilage matrix-associated protein C-terminal fragment
Impaired interaction with DWORF and PLN; when associated with A-795 and A-809.
Impaired interaction with DWORF and PLN; when associated with A-796 and A-802.
Impaired interaction with DWORF and PLN; when associated with A-802 and A-809.
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
SH3 and multiple ankyrin repeat domains protein 1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
RNA 3'-terminal phosphate cyclase-like protein
Zinc finger and BTB domain-containing protein 14
Does not lead to glycosylation, suggesting that the non-cleavable signal sequence remains partly or entirely embedded in the membrane.
FXYD domain-containing ion transport regulator
FXYD domain-containing ion transport regulator 3
In strain: A/J, BALB/cJ, P/J, SODL/EI, SEA/GNJ, NZW/LACJ and VM/DK.
In strain: A/J, BALB/cJ, SODL/EI, SEA/GNJ, NZW/LACJ and VM/DK.
4 X 11 AA tandem repeats of VQLQP-[AL]-[QT]-[EG]-[VQ]-[ATV]-[ST]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase
Exocyst complex component 3-like protein 4
Patatin-like phospholipase domain-containing protein 5
NACHT, LRR and PYD domains-containing protein 12
Synaptonemal complex central element protein 3
Protein-S-isoprenylcysteine O-methyltransferase
Copper type II ascorbate-dependent monooxygenase C-terminal
Copper type II ascorbate-dependent monooxygenase N-terminal
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase
Peptidyl-glycine alpha-amidating monooxygenase
Peptidylglycine alpha-hydroxylating monooxygenase
Helical; Voltage-sensor; Name=Segment S4
Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin
Important for normal, slow channel gating
In Pgu; chronic motor incoordination; decreases the number of functional channels at the cell surface.
Potassium voltage-gated channel subfamily A member 2
Interacts with hydroxy-aryl-aldehyde inhibitors
Proton acceptor; for protein kinase activity
Serine/threonine-protein kinase/endoribonuclease IRE1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Tumor necrosis factor receptor superfamily member 19
BTB/POZ domain-containing protein KCTD20
Methyl-CpG binding protein 2/3 C-terminal
Methyl-CpG-binding domain protein 3-like 1
High affinity immunoglobulin epsilon receptor subunit gamma
Impairs IgE-induced mast cell activation in the presence of antigen; Impairs IgE-induced mast cell survival in the absence of antigen.
Impairs IgE-induced mast cell activation in the presence of antigen; Impairs IgE-induced mast cell survival in the absence of antigen; when associated with P-65. Impairs IL3-induced production of IL4 by basophils; when associated with P-65.
Impairs IgE-induced mast cell activation in the presence of antigen; Impairs IgE-induced mast cell survival in the absence of antigen; when associated with P-76. Impairs IL3-induced production of IL4 by basophils; when associated with P-76.
Impairs interaction with CSF2RB. Impairs IL3-induced production of IL4 by basophils.
Increases IL3-induced production of IL4 by basophils.
Rho guanine nucleotide exchange factor 4
Almost completely inactive UDP-GlcNAc transport activity.
Almost completely inactive UDP-GlcNAc transport activity. Does not affect membrane localization.
Completely abolishes the biosynthesis of GlcNAc glycoconjugates.
Decreases UDP-GlcNAc transport activity.
Does not affect UDP-GlcNAc transport activity.
Increases UDP-GlcNAc transport activity.
Severe impairment of UDP-GlcNAc transport activity.
Severe impairment of UDP-GlcNAc transport activity. Does not affect membrane localization.
In isoform 3, isoform 5, isoform 6, isoform 7, isoform 9 and isoform 8.
In isoform 4, isoform 5, isoform 7 and isoform 9.
Regulating synaptic membrane exocytosis protein 2
Serine/threonine-protein kinase MRCK beta
TD and POZ domain-containing protein 1-like
All-trans-retinol dehydrogenase [NAD(+)] ADH4
Strongly increases NAD-retinol dehydrogenase activity.
Strongly increases activity towards ethanol, increases KM for benzoquinone 10-fold.
Involved in interaction with pre-mRNA 5' splice site
Required for interaction with EFTUD2 and SNRNP200
Restriction endonuclease homology domain
Protein mono-ADP-ribosyltransferase PARP9
Neuronal acetylcholine receptor subunit alpha-6
DNA-directed RNA polymerase RBP11-like dimerisation
V-set and immunoglobulin domain-containing protein 1
G-protein coupled receptors family 2 profile 2
Ubiquitin carboxyl-terminal hydrolase 42
Probable tRNA (uracil-O(2)-)-methyltransferase
Mediates HDAC-dependent transcriptional repression
Polypeptide N-acetylgalactosaminyltransferase 3
Multiple inositol polyphosphate phosphatase 1
Receptor-type tyrosine-protein phosphatase C
Small ribosomal subunit protein uS17 N-terminal
Mitogen-activated protein kinase kinase kinase 4
Abolished activity without affecting avility to bind CX3CL1.
In DR/NN; abolished activity without affecting avility to bind CX3CL1.
Stabilizes the active site histidine for nucleophilic attack
RNA transcription, translation and transport factor protein
Abolishes inhibitory effect on FAS-mediated apoptosis. Does not change effect on TNFRSF1A-mediated apoptosis.
ER degradation-enhancing alpha-mannosidase-like protein 3
MKI67 FHA domain-interacting nucleolar phosphoprotein
Potassium channel domain-containing protein
Decreased cholesterol binding. Nearly abolishes cholesterol transport activity.
Decreased cholesterol binding. Strongly decreased cholesterol transport activity.
Loss of cholesterol binding. Abolishes cholesterol transport activity.
Loss of cholesterol binding. Abolishes cholesterol transport activity. Abolishes stimulation of biliary cholesterol secretion.
NPC intracellular cholesterol transporter 2
No effect on cholesterol binding. Strongly decreased cholesterol transport activity.
No significant effect on biliary cholesterol secretion.
Cilia- and flagella-associated protein 43
Immediate early response 3-interacting protein 1
In isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8.
In strain: 129/Sv; requires 2 nucleotide substitutions.
NACHT, LRR and PYD domains-containing protein 5
Carcinoembryonic antigen-related cell adhesion molecule 15
Abolishes Rac1 activation; when associated with A-1427.
Abolishes Rac1 activation; when associated with E-1435.
2 X 8 AA tandem repeats of A-X-A-K-A-P-A-[KQ]
Non-structural maintenance of chromosome element 4 C-terminal
G-protein coupled receptors family 3 profile
Cytoplasmic polyadenylation element-binding protein 4
Important for the positionning of RRM1 relative to RRM2
Abrogates transcriptional repression of MYOD1.
Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane
Impairs TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane.
Neuronal acetylcholine receptor subunit alpha-7
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1
Nonsense-mediated mRNA decay factor SMG9
U11/U12 small nuclear ribonucleoprotein 48 kDa protein
Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole
Succinate--hydroxymethylglutarate CoA-transferase
In ketu; homozygotes mice are both male- and female-sterile. In the testis, mutant germ cells carry out an abortive attempt at meiosis: They express hallmark meiotic proteins and initiate recombination, but fail to fully extinguish the spermatogonial mitotic division program, proceed prematurely to an aberrant metaphase-like state, and undergo apoptosis. The mutation probably causes misfolding or protein aggregation. Slightly reduced helicase activity.
Ergosterol biosynthetic protein 28 homolog
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Class E basic helix-loop-helix protein 41
Low-density lipoprotein receptor-related protein 2
PxLPxI/L motif 1; mediates interaction with ANKRA2
PxLPxI/L motif 2; mediates interaction with ANKRA2
Rhomboid-related protein 2, C-terminal fragment
Rhomboid-related protein 2, N-terminal fragment
O-linked (Xyl...) (chondroitin sulfate) serine
Pulmonary surfactant-associated protein B
Phosphoserine; by MAPKAPK2, MAPKAPK3, MAPKAPK5, PKA and PKC
Phosphoserine; by MAPKAPK2, MAPKAPK3, PKA and PKC
Sufficient for interaction with RAB11A and for guanine nucleotide exchange activity
Abolishes interaction with NHERF1 and effect on synapse formation.
Helical; Signal-anchor for type III membrane protein
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Sphingosine-1-phosphate transporter SPNS2
Platelet-derived growth factor receptor alpha
Disintegrin and metalloproteinase domain-containing protein 10
Loss of binding to AP2A1 and AP2A2. Decreased localization to the plasma membrane.
Ribose-phosphate pyrophosphokinase N-terminal
Anaphase-promoting complex subunit 4-like WD40
Doublecortin domain-containing protein 2C
Mutant male mice exhibit meiotic arrest, azoospermia and infertility. Females exhibit infertility or low reproductive capacity.
DNA-directed RNA polymerase III subunit RPC7
Ubiquitin carboxyl-terminal hydrolase 36
Band 4.1-like protein 3, N-terminally processed
In isoform 2, isoform 3, isoform 5, isoform 6 and isoform 7.
In isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8.
N-acetylthreonine; in Band 4.1-like protein 3, N-terminally processed
Neurogenic locus notch homolog protein 2
No effect on O-glycosylation by POGLUT1. Loss of O-xylosylation.
RNA binding motif protein, X-linked-like-1
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
Polypeptide N-acetylgalactosaminyltransferase 16
Does not inhibit cell survival upon DNA damage. Not phosphorylates p53/TP53.
Kelch repeat and BTB domain-containing protein 12
Ubiquitin carboxyl-terminal hydrolase 28
Selection and upkeep of intraepithelial T-cells protein 5
Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate
Schiff-base intermediate with dihydroxyacetone-P
Does not affect nuclear localization pattern
Required for correct nuclear localization and exclusion from the nucleoli
Guanine nucleotide-binding protein subunit beta-5
Involved in nuclear speckle localization
Region N; interaction with decapping machinery
Abolishes homodimerization. Loss of E3 ubiquitin ligase activity.
Abolishes homodimerization. Strongly reduced E3 ubiquitin ligase activity.
SUMO interaction motif 1; mediates the binding to polysumoylated substrates
SUMO interaction motif 2; mediates the binding to polysumoylated substrates
SUMO interaction motif 3; mediates the binding to polysumoylated substrates
SUMO interaction motif 4; mediates the binding to polysumoylated substrates
Thioredoxin-related transmembrane protein 1
Pyroglutamylated RF-amide peptide receptor
Mitochondrial calcium uniporter regulator 1
12 X 11 AA tandem repeats of [MV]-G-I-P-P-P-P-P-L-P-G
Strongly reduced interaction with SPIRE1.
Coiled-coil domain-containing protein 127
Cullin-associated NEDD8-dissociated protein 2
Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial
Diencephalon/mesencephalon homeobox protein 1
Interaction with OTX2 and is required for repressor activity
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Acetylserotonin O-methyltransferase dimerisation
In strain: C57BL/6J, 129/Sv, BALB/c, FVB/N and more; reduces protein expression.
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
TATA box binding protein associated factor (TAF) histone-like fold
Sodium-dependent phosphate transport protein 2B
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
Necessary for stimulating PAPOLA activity
Sufficient for interaction with CPSF1 and CSTF3
Abolished ubiquitination by the SCF(FBXL2) complex.
Abolishes inhibition of NFKB2 processing; when associated with A-52.
Abolishes inhibition of NFKB2 processing; when associated with A-55.
Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)
Reduces 'Lys-48'-linked polyubiquitination; when associated with R-106.
Reduces 'Lys-48'-linked polyubiquitination; when associated with R-155.
Strongly reduces 'Lys-63'-linked ubiquitination; when associated with A-69. Abolishes inhibition of NFKB2 processing; when associated with A-67.
Strongly reduces 'Lys-63'-linked ubiquitination; when associated with A-69. Abolishes inhibition of NFKB2 processing; when associated with A-69.
Oxysterol-binding protein-related protein 3
Maintains GTP-bound state, leading to activate mTORC1. Knockin mice develop normally, but die within 1 day postpartum because of constitutive activation of mTORC1 that prevents response to fasting. Inhibition of mTORC1 is required for neonatal autophagy and thus nutrient homeostasis.
Suppressor APC domain-containing protein 2
Loss of inhibition of SPI1-mediated transcriptional activation.
Complement C1q and tumor necrosis factor-related protein 9
No change in the interaction with ADIPOQ.
H-2 class I histocompatibility antigen, Q7 alpha chain
MHC class I-like antigen recognition-like
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Minimal loss of kinase activity; when associated with E-366.
Minimal loss of kinase activity; when associated with E-368.
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Proliferating cell nuclear antigen PCNA C-terminal
Proliferating cell nuclear antigen PCNA N-terminal
In isoform 2, isoform B2 and isoform C2.
Strongly reduced interaction with PCDH15.
V-type proton ATPase 116 kDa subunit a 2
Tumor necrosis factor ligand superfamily member 13
U6 snRNA-associated Sm-like protein LSm6
O-linked (Xyl...) (glycosaminoglycan) serine
Able to partially restore the interaction with the G-205 GATA1 mutant, which is usually unable to interact with ZFPM1.
Abolishes interaction with CTBP2; it however does not abolish the corepressor activity in erythropoiesis.
Does not affect the interaction with GATA1.
Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-612 and/or A-985.
Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-718 and/or A-985.
Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-612; A-718 and/or A-985.
Slightly affects the interaction with GATA1.
Slightly affects the interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-612 and/or A-718.
Transforms the C2HC-type zinc finger into a C2H2-type, leading to abolition of interaction with GATA1.
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Transcription factor CBF/NF-Y/archaeal histone
Ribosome-recycling factor, mitochondrial
Peroxisomal multifunctional enzyme type 2
von Willebrand factor A domain-containing protein 5A
Cytosolic arginine sensor for mTORC1 subunit 1
Potassium voltage-gated channel subfamily H member 3
Abolishes dimethylation. Impairs transcription coactivator activity and regulation of alternative splicing. No effect on methyltransferase activity.
Abolishes histone methyltransferase activity and coactivator activity.
Abolishes histone methyltransferase activity and reduces coactivator activity.
Histone-arginine methyltransferase CARM1
Loss of S-adenosyl-L-methionine binding. Loss of protein methyltransferase activity.
Loss of S-adenosyl-L-methionine binding. Loss of protein methyltransferase activity. Localized in the cytosol.
Loss of S-adenosyl-L-methionine binding. Loss of protein methyltransferase activity. Localized in the nucleus.
Loss of protein methyltransferase activity.
Reduces protein methyltransferase activity.
GPI ethanolamine phosphate transferase 1 C-terminal
Histone-lysine N-methyltransferase SETD5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Homeodomain-interacting protein kinase 4
Mitochondrial import receptor subunit TOM6 homolog
Adenosine 3'-phospho 5'-phosphosulfate transporter 2
FXYD domain-containing ion transport regulator 5
Amino acid transporter heavy chain SLC3A2
Interchain (with C-164 in SLC7A5; C-158 in SLC7A11 and C-153 in SLC7A8)
Loss of interchain disulfide bond. No effect on guidance of SLC7A5 to the plasma membrane.
Peptidase metallopeptidase domain-containing protein
Zinc finger and SCAN domain containing protein 4C
C; actin-binding and synaptic-vesicle binding
Zinc finger CCCH domain-containing protein 14
Regenerating islet-derived protein 3-alpha 15 kDa form
Regenerating islet-derived protein 3-alpha 16.5 kDa form
Class-II-associated invariant chain peptide
H-2 class II histocompatibility antigen gamma chain
MHC class II-associated invariant chain trimerisation
MHC class II-associated invariant chain/CLIP MHC II-interacting
No addition of glycosaminoglycan; no effect on the synthesis of the protein.
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Tectonin beta-propeller repeat-containing protein 1
NAD(P)(+)--arginine ADP-ribosyltransferase
Pre-rRNA-processing protein TSR2 homolog
Probable ATP-dependent RNA helicase DDX47
Disheveled-associated activator of morphogenesis 1
Galactoside alpha-(1,2)-fucosyltransferase 1
Receptor-type tyrosine-protein phosphatase kappa
Macrophage-stimulating protein receptor alpha chain
Macrophage-stimulating protein receptor beta chain
'Ionic lock' involved in activated form stabilization
Plays an important role in the conformation switch to the active conformation
N-linked (GlcNAc...) (high mannose) asparagine
Translocon-associated protein subunit beta
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Impaired 1-alpha hydroxylase activity toward 25-hydroxyvitamin D3.
Impaired 1-alpha hydroxylase activity toward 25-hydroxyvitamin D3. Impaired heme binding.
Homologous-pairing protein 2 winged helix
Ribosomal RNA small subunit methyltransferase NEP1
Bromodomain and WD repeat-containing protein 1
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
Proline-serine-threonine phosphatase-interacting protein 2
Iroquois-class homeodomain protein IRX-1
SH3 domain and tetratricopeptide repeat-containing protein 2
Mannose-1-phosphate guanyltransferase alpha
Huntingtin-interacting protein 1-related protein
Phosphotyrosine; by autocatalysis and SRC
Vascular endothelial growth factor receptor 3
Cilia- and flagella-associated protein 90
Interaction with the 5'-triphosphate group of PPP-RNA
Interferon-induced protein with tetratricopeptide repeats 1
Necessary for the nuclear export of the 60S ribosomal subunit
Nuclear and nucleolar localization signal
Fatty acid desaturase 2-like protein FADS2B
Mitochondrial import inner membrane translocase subunit Tim17-B
BRD4-interacting chromatin-remodeling complex-associated protein
Almost complete loss of 1-phosphatidylinositol-4-phosphate 5-kinase activity.
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Reduced 1-phosphatidylinositol-4-phosphate 5-kinase activity by 98%. Loss of actin-remodeling activity.
ADP-ribosylation factor-binding protein GGA3
U2 snRNP-associated SURP motif-containing protein
Translation machinery-associated protein 7
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Required for interaction with CBX5 and TBPL1
Zinc finger SWIM domain-containing protein 7
Pleckstrin homology-like domain family B member 2
Abrogates nuclear localization activity.
Clear and exclusive nuclear accumulation.
Significant loss of transactivation activity.
Slight reduction in transactivation activity.
Ciliary microtubule associated protein 1A
HA-stretch; determines single-channel conductance in 5-HT3 receptors
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
Mitochondrial import inner membrane translocase subunit Tim21
Cilia- and flagella-associated protein 44
Activating transcription factor 7-interacting protein 2
Leucine-rich repeat-containing protein 1
Essential for ATP binding and ATPase activity
Retinal-specific phospholipid-transporting ATPase ABCA4
Necessary for localization to the mitochondria
Ankyrin repeat domain-containing protein 13A
Isochorismatase domain-containing protein 2A
F-box and leucine-rich repeat protein 13
Pleckstrin homology domain-containing family G member 6
Calcium/calmodulin-dependent protein kinase type 1B
Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Ras association domain-containing protein 1
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Uncharacterized protein C11orf52 homolog
Acyl-coenzyme A synthetase ACSM4, mitochondrial
DNA replication complex GINS protein SLD5
DNA replication complex GINS protein SLD5, N-terminally processed
N-acetylthreonine; in DNA replication complex GINS protein SLD5, N-terminally processed
Interaction with NCK2 second and third SH3 domain (minor)
Interaction with NCK2 third SH3 domain (major)
In chato; probable null mutation. Almost abolishes transcriptional repression. No effect on interaction with THRIM28. Embryonic development arrests at stage 9 dpc. Widespread morphogenetic defects are found in all germ layers, associated with defective convergent extension movements. The anterior-posterior axis is abnormally shortened, somites are mediolaterally expanded, and the neural tube fails to close normally. Morphogenesis of most mesodermal tissues is also defective. The definitive endoderm fails to narrow and elongate leading to an open gut tube. Extraembryonic tissues are also abnormal with bubble-like protrusions in the yolk sac, aberrant migration of extraembryonic mesoderm, and incomplete placental development. Abolishes interaction with TRIM28; when associated with P-154.
Increases transcriptional repression. No effect on interaction with THRIM28.
No effect on transcriptional repression.
No effect on transcriptional repression. Abolishes interaction with TRIM28; when associated with P-64.
No effect on transcriptional repression. No effect on interaction with THRIM28.
Strongly decreases transcriptional repression. No effect on interaction with THRIM28. No effect on interaction with THRIM28.
Inactive carboxypeptidase-like protein X2
Ribonucleoside-diphosphate reductase large subunit
ADP-ribosylation factor-binding protein GGA1
Disintegrin and metalloproteinase domain-containing protein 24
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
In isoform Tau-A, isoform Tau-B, isoform Tau-C, isoform Tau-D and isoform Tau-E.
In isoform Tau-B, isoform Tau-C, isoform Tau-D and isoform Tau-E.
Phosphoserine; by MARK1, BRSK1, BRSK2 and PHK
Attenuates activation by MAPK1/ERK1 and MAPK3/ERK2.
Loss of interaction with PDPK1 and phosphorylation at S-227.
Loss of phosphorylation and activation by PDPK1.
Loss of phosphorylation by PDPK1; loss of activation by PDPK1 and EGF.
Phosphoserine; by autocatalysis and MAPKAPK2
Kinase-dead. Loss of autophosphorylation but has no effect on regulation of cell adhesion.
Mediates interaction with ANKS1A and ANKS1B
Mediates interaction with PIK3CG and required for endocytosis
Reduced phosphorylation and reduced association with FYN.
Constitutively active. Interacts with PARD6 proteins.
Polybasic region; required for nuclear import
Ras-related C3 botulinum toxin substrate 1
Ubiquitin carboxyl-terminal hydrolase 43
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Decreased affinity for NPC2. Loss of function in cholesterol transport. No effect on subcellular location. Strongly decreased affinity for NPC2; when associated with A-421.
Important for cholesterol binding and cholesterol transfer from NPC1 to liposomes
In Npc1-nmf164; strongly decreased protein levels. Causes abnormal lipid storage in the spleen and liver, loss of cerebellar Purkinje cells and age-dependent ataxia.
Loss of function giving rise to cholesterol accumulation in kidney, liver, lung and spleen. No effect on lysosomal location. Mice display age-dependent weight loss, neurodegeneration with loss of Purkinje cells, ataxia and premature death at a median age of 84 days.
NPC intracellular cholesterol transporter 1
Strongly decreased affinity for NPC2. No effect on lysosomal location.
Strongly decreased affinity for NPC2; when associated with 503-A-A-504.
Zinc finger protein with KRAB and SCAN domains 3
V-type proton ATPase 21 kDa proteolipid subunit c""" /id="PRO_0000071778
Signal recognition particle 9 kDa protein
Abolished inhibition by nitrofuran derivatives C-178 and C-176; abolished palmitoylation.
Abolished sumoylation by TRIM38, leading to decreased stability.
Cyclic dinucleotide-binding domain (CBD)
Decreased relocalization to autophagosomes and subsequent degradation.
Induces a decrease in phosphorylation by TBK1, leading to reduced ability to activate IRF3.
Mediates interaction with ZDHHC1 and ZDHHC11
Strongly decreases affinity for the synthetic compound 5,6-dimethylxanthenone 4-acetic acid (DMXAA).
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Important for apoenzyme conformational stability
Glucosamine/galactosamine-6-phosphate isomerase
Important for interaction with RAB9A and RAB9B
Required for interaction with RAP family members
Tumor necrosis factor receptor superfamily member 13B
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
WAP four-disulfide core domain protein 18
Histone RNA hairpin-binding protein RNA-binding
Melanocortin-2 receptor accessory protein
Keratinocyte-associated transmembrane protein 2
In isoform 3, isoform 4, isoform 6 and isoform 9.
Serine/threonine specific protein phosphatases
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Loss of palmitoylation; when associated with S-3.
Loss of palmitoylation; when associated with S-4.
Neuron-specific vesicular protein calcyon
ATP synthase membrane subunit K, mitochondrial
ATP-sensitive inward rectifier potassium channel 12
Inward rectifier potassium channel C-terminal
Potassium channel inwardly rectifying Kir N-terminal
Potassium channel inwardly rectifying transmembrane
Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium
Coiled-coil domain-containing protein 159
Necessary and sufficient for U6 snRNA binding
Squamous cell carcinoma antigen recognized by T-cells 3
Peptide chain release factor 1-like, mitochondrial
NKG2-D type II integral membrane protein
Carnitine O-palmitoyltransferase 1, muscle isoform
Hematopoietically-expressed homeobox protein Hhex
Does not alter dystroglycan processing in vitro.
Localized to the perinuclear region but not retained in or targeted to the medial part of the Golgi apparatus.
Not properly targeted to the Golgi apparatus; strongly reduced secretion to the medium; localizes mainly to the ER compartment. Strongly impaired glycosylation of alpha-dystroglycan in muscles and brain.
Reduced secretion to the medium; localizes mainly to the Golgi apparatus. Mild dystrophy with reduced alpha-dystroglycan glycosylation and no apparent brain defects.
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
In wpy; widespread embryonic dysmorphologies, including highly penetrant polydactyly of all four limbs as well as craniofacial defects. Mice develop cystic kidney disease.
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Beta-1,3-N-acetylglucosaminyltransferase manic fringe
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)
WD repeat domain phosphoinositide-interacting protein 2
Peptidyl-prolyl cis-trans isomerase FKBP11
Proprotein convertase subtilisin/kexin type 4
H/ACA ribonucleoprotein complex subunit 2
Caspase recruitment domain-containing protein 11
Phosphoserine; by PKC/PRKCB and PKC/PRKCQ
Slightly decreased interaction with BCL10.
Strongly decreased interaction with BCL10.
Speedy/Ringo box; Required for CDK-binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
CO dehydrogenase flavoprotein C-terminal
Loss of activity with different N-heterocyclic compounds as substrates. 60% reduction of activity with benzaldehyde.
No effect on kinetic constants with smaller substrates like benzaldehyde or phthalazine. Decreases substrate affinity and slightly increases catalytic efficiency for bulkier substrates like phenanthridine.
No effect on substrate affinity but decreases catalytic efficiency for smaller substrates like benzaldehyde or phthalazine. Increases substrate affinity and activity for bulkier substrates like phenanthridine.
Proton acceptor; for azaheterocycle hydroxylase activity
Slightly decreases substrate affinity but no effect on activity with smaller substrates like benzaldehyde or phthalazine. Increases catalytic efficiency with bulkier substrates like phenanthridine or more charged substrates like N1-methylnicotinamide.
Phosphatidylinositol 3-kinase regulatory subunit beta
Disintegrin and metalloproteinase domain-containing protein 8
N6,N6,N6-trimethyllysine; by METTL21A; in vitro
Important for surfactant activity and antibacterial properties
Pre-rRNA-processing protein RIX1 N-terminal
Proline-, glutamic acid- and leucine-rich protein 1
Required for modulation of ESR1 transcriptional activity
Localizes to cytoplasm; when associated with 22-QQQ-24.
Localizes to cytoplasm; when associated with 37-NNN-39.
Not exported to the cytoplasm; when associated with A-234.
Not exported to the cytoplasm; when associated with A-236.
Required for localization to the nucleolus and midbody
Dramatically decreased Th2 cell differentiation.
Fails to induce Th2 cytokine production.
Moderately decreased Th2 cell differentiation.
Trans-acting T-cell-specific transcription factor GATA-3
Abolishes expression at the cell membrane.
Interferon-induced transmembrane protein 5
No effect on location at the cell membrane. Abolishes palmitoylation; when associated with A-52 and A-53.
Strongly reduces expression at the cell membrane. Reduces palmitoylation; when associated with A-52. Abolishes palmitoylation; when associated with A-52 and A-86.
Strongly reduces expression at the cell membrane. Reduces palmitoylation; when associated with A-53. Abolishes palmitoylation; when associated with A-53 and A-86.
Transmembrane anterior posterior transformation protein 1
Serine/threonine-protein phosphatase 2A regulatory subunit B" subunit gamma
WD repeat beta-propeller B; Interaction with CUL4A
WW domain-containing adapter protein with coiled-coil
X-linked lymphocyte-regulated protein 3A
Tumor necrosis factor receptor superfamily member EDAR
VPS35 endosomal protein-sorting factor-like
In Rex wavy coat; mice exhibit curly hair and vibrissae. The diameter of the hair shaft is irregular due to morphological abnormalities in all three layers of the irs.
5-glutamyl coenzyme A thioester intermediate
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
Binds CBX1 and CBX3 chromo shadow domains
Necessary for homodimerization and competence for chromatin assembly
Sufficient for binding to RE2 sequence motifs
Putative sodium-coupled neutral amino acid transporter 11
Necessary for interaction with PPP2CA and PPP2R1A
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
Phosphoinositide 3-kinase regulatory subunit 4
High mobility group nucleosome-binding domain-containing protein 3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
Nuclear receptor subfamily 4 group A member 1
Phosphoserine; by PKA, RPS6KA1 and RPS6KA3
Required for binding NBRE-containing DNA
Peripheral-type benzodiazepine receptor-associated protein 1
Uncharacterized protein C14orf119 homolog
ZZ-type zinc finger-containing protein 3
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
CCR4-NOT transcription complex subunit 9
Abolishes enzyme activity. Abolishes autocatalytic processing.
Complete loss of activity. Abolishes autocatalytic processing.
Important for localization to the centrosome
FHF complex subunit HOOK-interacting protein 1A
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2
Matrix metalloproteinase-23, soluble form
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7
Protein transport protein Sec61 subunit alpha isoform 2
Dominant negative, severely disrupts circadian rhythmicity of transcription.
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
No effect on MAGED1 binding. Decrease in ubiquitination of MAGED1. No inhibition of DLX5-dependent transcriptional activity.
4-hydroxyphenylpyruvate dioxygenase-like protein
Ankyrin repeat and sterile alpha motif domain-containing protein 1B
R3H and coiled-coil domain-containing protein 1
Ubiquinol-cytochrome c reductase complex assembly factor 1
Chromatin accessibility complex protein 1
Echinoderm microtubule-associated protein-like 2
Abolishes PKA-mediated phosphorylation. No enhanced calcium release. Abolishes PKA-mediated phosphorylation: When associated with A-990; A-1190; A-1351 and A-1581.
Inositol 1,4,5-trisphosphate receptor type 2
No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-1190; A-1351 and A-1581.
No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1351.
No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1581.
No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1351 and A-1581.
No effect on PKA-mediated phosphorylation. Enhanced calcium release on PKA activation.
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Complete loss of TRAF7-mediated SUMOylatiom; when associated with R-499.
Complete loss of TRAF7-mediated SUMOylatiom; when associated with R-523.
Mas-related G-protein coupled receptor member B1
Cytochrome b-c1 complex subunit 1, mitochondrial
Guanine nucleotide-binding protein G(o) subunit alpha
Abolishes AMPK-mediated phosphorylation; when associated with A-177.
Abolishes AMPK-mediated phosphorylation; when associated with A-538.
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Strongly reduces coactivation of RORA activity.
Cysteine-rich hydrophobic domain-containing protein 2
Abolishes methylation, no effect on subcellular location.
Essential for stabilizing binding to COTL1
Responsible for the low discrimination between dNTP and rNTP
Abolished phosphorylation by GSK3 and decreased acetyltransferase activity. Impaired ability to activate the cGAS-STING antiviral response in knockin mice. Lean phenotype caused by impaired ability to promote the synthesis of diacylglycerol in knockin mice. Decreased ability to promote homologous recombination (HR)repair in response to DNA double-strand breaks (DSBs).
Impaired phosphorylation and decreased acetyltransferase activity, leading to decreased ability to promote homologous recombination (HR)repair in response to DNA double-strand breaks (DSBs).
Mimics phosphorylation; constitutively active mutant that shows constitutive protein acetyltransferase activity. Increased ability to promote homologous recombination (HR)repair in response to DNA double-strand breaks (DSBs).
Mimics phosphorylation; constitutively active mutant that shows constitutive protein acetyltransferase and acyltransferase activities in knockin mice. Increased ability to promote homologous recombination (HR)repair in response to DNA double-strand breaks (DSBs).
Abolishes interaction with integrins ITGB1 and ITGB3.
Interaction with membranes containing phosphatidylinositol phosphate
No effect on in vitro phosphorylation by PKC.
Phospholipid phosphatase-related protein type 1
T-cell-specific guanine nucleotide triphosphate-binding protein 1
T-cell-specific guanine nucleotide triphosphate-binding protein 2
Tumor necrosis factor receptor superfamily member 4
Zinc finger CCHC-type and RNA-binding motif-containing protein 1
Cilia- and flagella-associated protein 61 N-terminal
Transcription termination factor 1b, mitochondrial
Ionotropic glutamate receptor C-terminal
Ionotropic glutamate receptor L-glutamate and glycine-binding
Proheparin-binding EGF-like growth factor
IQ motif and SEC7 domain-containing protein 1
Ankyrin repeat domain-containing protein 23
Almost complete loss of interaction with MAPK8.
Greatly decreased interaction with MAPK8 and ligase activity.
Inhibits in vitro interaction between ITCHHECT domain and PRR/WW motifs. More sensitive to in vitro proteolysis.
Loss of ubiquitin protein ligase activity.
No loss of MAPK8-mediated phosphorylation and no effect on ligase activity. Almost complete inactivation of ligase activity; when associated with A-199. Greatly reduced MAPK8-mediated phosphorylation; when associated with A-199 or A-222. Completely abolishes MAPK8-mediated phosphorylation; when associated with A-199 and A-222.
No loss of MAPK8-mediated phosphorylation and no effect on ligase activity. Almost complete inactivation of ligase activity; when associated with A-232. Greatly reduced MAPK8-mediated phosphorylation; when associated with A-222 or A-232. Completely abolishes MAPK8-mediated phosphorylation; when associated with A-222 and A-232.
No loss of MAPK8-mediated phosphorylation. Greatly reduced MAPK8-mediated phosphorylation; when associated with A-199 or A-232. Completely abolishes MAPK8-mediated phosphorylation; when associated with A-199 and A-232.
In Past-time (Psttm) mutant; causes period shortening due to Cry1 and Cry2 destabilization.
Cell cycle checkpoint control protein RAD9A
Steroidogenic acute regulatory protein, mitochondrial
Disintegrin and metalloproteinase domain-containing protein 1a
Probable ATP-dependent RNA helicase DHX34
Condensin II complex subunit H2 N-terminal
Condensin-2 complex subunit H2 C-terminal
Patatin-like phospholipase domain-containing protein 6
Epididymal secretory glutathione peroxidase
In XID; prevents interaction with ARID3A.
Inositol-(1,3,4,5)-tetrakisphosphate 1-binding
Loss of activity and no phosphorylation.
(S/T)X(I/L)P motif 3; required for interaction with MAPRE1
Mediates interaction with CDK5RAP2 and is required for homodimerization and microtubule bundle formation
Mediates interaction with beta-tubulin and is required for microtubule bundle formation
Probable helicase with zinc finger domain
Reduces binding to phosphoinositide; when associated with Gln-109.
Reduces binding to phosphoinositide; when associated with Gln-33; Gln-34 and Gln-38.
Reduces binding to phosphoinositide; when associated with Gln-33; Gln-34 and Gln-42.
Reduces binding to phosphoinositide; when associated with Gln-33; Gln-38 and Gln-42.
Reduces binding to phosphoinositide; when associated with Gln-34; Gln-38 and Gln-42.
Reduces binding to phosphoinositide; when associated with Gln-93.
Tumor necrosis factor alpha-induced protein 8-like protein 3
11 X 7 AA tandem repeats of [DR]-P-Y-R-[LI][AG][QHP]
13 X 10 AA tandem repeats of L-A-[ST]-[NSG]-[TS]-MDSQM
2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-S
3 X 11 AA tandem repats of P-P-L-P-P-E-E-P-P-[TME]-[MTG]
3 X tandem repeats of [ST]-P-[VLI]-R-[RL]-[RK]-[RF]-S-R
Eukaryotic translation initiation factor 5A-1
Ornithine aminotransferase, mitochondrial
PC-esterase domain-containing protein 1B
FERM and PDZ domain-containing protein 1
ATP-dependent 6-phosphofructokinase, platelet type
5'-AMP-activated protein kinase subunit gamma-1
Migration and invasion-inhibitory protein
Cation-independent mannose-6-phosphate receptor
In ST; causes an absence of mature T-cells due to thymocyte development being arrested at the CD4+CD8+ stage.
DINNN-motif; mediates interaction with SPSB1, SPSB2 and SPSB4
Significant loss of interaction with SPSB2.
ATP-binding cassette sub-family D member 3
Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation)
Phosphotyrosine; by JAK1, JAK2 and PDGFR
Mediates heterotypic interactions between MLXIP and MLX and is required for cytoplasmic localization
No reduction of association with the recycling endosome membranes and does activate TNIK; when associated with G-176.
No reduction of association with the recycling endosome membranes and does activate TNIK; when associated with G-177.
Necessary for the association with the MRN complex
Serine/threonine-protein phosphatase 4 regulatory subunit 2
Abolished calmodulin-dependent protein kinase activity. Abolished ability to phosphorylate STAT1.
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Abolishes phosphorylation by PKA. No effect on ability to bind DNA nor on transactivation activity.
Loss of MAPK8-mediated phosphorylation and no protein degradation.
Loss of transactivation activity. No induction of histone H3 'K-4' acetylation.
Transcription factor NF-E2 45 kDa subunit
Zinc finger TRAF-type-containing protein 1
DNA-dependent protein kinase catalytic subunit
Lethal at 4-week-old; impaired hematopoiesis due to a decrease in hematopoietic stem and progenitor cells which causes a severe reduction in the numbers of erythrocytes, platelets, lymphocytes and neutrophils; reduced protein synthesis in bone marrow and fetal erythrocyte precursors; normal V(D)J recombination in B-cells; when associated with 2614-A--A-2616, A-2634 and A-2643.
Lethal at 4-week-old; impaired hematopoiesis due to a decrease in hematopoietic stem and progenitor cells which causes a severe reduction in the numbers of erythrocytes, platelets, lymphocytes and neutrophils; reduced protein synthesis in bone marrow and fetal erythrocyte precursors; normal V(D)J recombination in B-cells; when associated with A-2605, 2614-A--A-2616 and A-2634.
Lethal at 4-week-old; impaired hematopoiesis due to a decrease in hematopoietic stem and progenitor cells which causes a severe reduction in the numbers of erythrocytes, platelets, lymphocytes and neutrophils; reduced protein synthesis in bone marrow and fetal erythrocyte precursors; normal V(D)J recombination in B-cells; when associated with A-2605, 2614-A--A-2616 and A-2643.
Lethal at 4-week-old; impaired hematopoiesis due to a decrease in hematopoietic stem and progenitor cells which causes a severe reduction in the numbers of erythrocytes, platelets, lymphocytes and neutrophils; reduced protein synthesis in bone marrow and fetal erythrocyte precursors; normal V(D)J recombination in B-cells; when associated with A-2605, A-2634 and A-2643.
Normal erythrocyte and platelet numbers; when associated with A-2026 and 2050-A--A-2053.
Normal erythrocyte and platelet numbers; when associated with A-2026 and A-2038.
Normal erythrocyte and platelet numbers; when associated with A-2038 and 2050-A--A-2053.
Probable loss of catalytic activity. Severe reduction in the number of hematopoietic stem and progenitor cells in fetal liver. Slight reduction in translation during erythrocyte development in fetal liver.
Pro-neuregulin-4, membrane-bound isoform
Ribonucleoside-diphosphate reductase subunit M2 B
Uridine diphosphate glucose pyrophosphatase NUDT14
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Peroxisomal succinyl-coenzyme A thioesterase
Cysteine-rich secretory protein LCCL domain-containing 2
Hippocampus abundant transcript 1 protein
Abolishes lysosomal localization and results in mislocalization to the cell surface. Localizes to lysosomes when expressed with wild-type MFSD1.
In isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7.
Coiled-coil and C2 domain-containing protein 1B
Probable phospholipid-transporting ATPase IIA
V-set and transmembrane domain-containing protein 2-like protein
Involved in stabilization of the HSPB1:HSBP6 heterodimer
A disintegrin and metalloproteinase with thrombospondin motifs 15
Translocating chain-associated membrane protein 1-like 1
Myristoylated alanine-rich C-kinase substrate
tRNA (uracil-5-)-methyltransferase homolog A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial
Decrease in sensitivity to the scorpion toxin BMKM1.
Decreases interaction with CALM1 in the absence of calcium.
Decreases interaction with CALM1 in the presence and absence of calcium and reduces rate of channel inactivation.
Interchain; with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B; the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin)
Sodium channel protein type 8 subunit alpha
Voltage-gated Na+ ion channel cytoplasmic
Constitutively active. Dramatic reduction of the rate of GTP hydrolysis.
Dominant negative. Loss of interaction with AFDN, RLF and RALGDS.
Loss of interaction with AFDN, RLF and RALGDS; when associated with L-78.
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
Platelet-derived growth factor (PDGF) family profile
Platelet-derived growth factor (PDGF) family profile domain-containing protein
Dual specificity mitogen-activated protein kinase kinase 4
Delta and Notch-like epidermal growth factor-related receptor
Fails to be restricted to the somatodendritic compartment.
Interaction with AP1G1 and somatodendritic targeting
5-glutamyl glycerylphosphorylethanolamine
N6,N6,N6-trimethyllysine; alternate; by EEF1AKMT3
N6,N6-dimethyllysine; alternate; by EEF1AKMT3
N6-methyllysine; alternate; by EEF1AKMT3
ATP-binding cassette subfamily G member 4
ATP-binding cassette sub-family C member 2
Centrosomal protein of 170 kDa protein B
Ankyrin repeat and BTB/POZ domain-containing protein 2
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
In LCH mutant; abolishes formation of the tetramer and deoxynucleoside triphosphate (dNTPase) activity; when associated with C-112 and H-143.
In LCH mutant; abolishes formation of the tetramer and deoxynucleoside triphosphate (dNTPase) activity; when associated with L-109 and C-112.
In LCH mutant; abolishes formation of the tetramer and deoxynucleoside triphosphate (dNTPase) activity; when associated with L-109 and H-143.
Increased ability to restrict LINE-1 retrotransposon activity.
Mimicks phosphorylation state, reduced ability to restrict LINE-1 retrotransposon activity.
Acetylcholinesterase collagenic tail peptide
Tubulin polymerization-promoting protein family member 3
Mediates interaction with CSNK1A1 and is required for FAM83H activity in keratin cytoskeleton organization
Gamma-aminobutyric acid receptor subunit pi
Almost completely blocks the ability to traffic to cilia. Disrupts interaction with RAB8A. Disrupts interaction with ARF4.
Almost completely blocks the ability to traffic to the cilia; when associated with 3872-A-A-3873. Affects palmitoylation; when associated with 3872-A-A-3873. Disrupts interaction with RAB8A; when associated with 3872-A-A-3873. Disrupts interaction with ARF4; when associated with 3872-A-A-3873.
Almost completely blocks the ability to traffic to the cilia; when associated with A-3869. Affetcs palmitoylation; when associated with A-3869. Disrupts interaction with RAB8A; when associated with A-3869. Disrupts interaction with ARF4; when associated with A-3869.
Little affects the ability to traffic to the cilia. Does not affect interaction with RAB8A. Does not affect interaction with ARF4.
Reduces the ability to traffic to the cilia.
Reduces the ability to traffic to the cilia. Reduces interaction with RAB8A.
Reduces the ability to traffic to the cilia. Reduces interaction with RAB8A. Does not affect interaction with ARF4.
Sufficient for interaction with AKTIP and VPS18
Sufficient for interaction with microtubules
Accumulation in the nucleus due to defects in nuclear export.
Basic leucine zipper transcriptional factor ATF-like 2
Absence of sumoylation. Increased FGF4 activation. No effect on nuclear localization.
Cytochrome c oxidase subunit 7A1, mitochondrial
GDH/6PGL endoplasmic bifunctional protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Solute carrier organic anion transporter family member 1B2
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial
Gap junction alpha-1 protein (Cx43) C-terminal
Phosphoserine; by PKC/PRKCG and PKC/PRKCD
Uncharacterized serine/threonine-protein kinase SBK3
Decreased specific binding to triglyceride. Decreased lipid droplet size. No change in protein expression levels and subcellular localization to the ER.
Complete loss of STAT3 activation; in association with F-443.
Complete loss of STAT3 activation; in association with F-493.
Fibronectin type-III domain-containing protein
Post-GPI attachment to proteins factor 6
Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity
Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity
Required for binding the 'RVXF' binding groove of PPP1CC
CBY1-interacting BAR domain-containing protein 2
Mothers against decapentaplegic homolog 9
Complete loss of kinase activity. Phosphorylation is restored by co-transfection with wild-type protein.
Does not affect kinase activity nor secretion to the extracellular medium.
Extracellular tyrosine-protein kinase PKDCC
Most homozygous embryos are non-viable and show craniofacial, ophthalmologic, cardiac, visceral, and hemopoietic abnormalities.
Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recycling
Suppression of SIX3-binding to rhodopsin promoter. Impairs the ability of Six3 to stimulate RHO transcription.
Lipocalin/cytosolic fatty-acid binding domain-containing protein
Inositol polyphosphate-related phosphatase
Phosphatidylinositol polyphosphate 5-phosphatase type IV
Antiviral innate immune response receptor RIG-I
Greatly decreases 'K-48'-linked ubiquitination.
Hairy and enhancer of split-related protein HELT
Type 2 lactosamine alpha-2,3-sialyltransferase
No effect on interaction with PI3 kinase.
CCR4-NOT transcription complex subunit 3
Coiled-coil domain-containing protein 83
A-kinase anchor protein 1, mitochondrial
Gain of SCFA-independent constitutive G protein-coupled receptor activity.
Ral guanine nucleotide dissociation stimulator-like 2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
Killer cell lectin-like receptor subfamily B member 1A
7SK snRNA methylphosphate capping enzyme
Abolishes LPC transport. Abolishes LPC transport; when associated with A-92.
Significant reduction in LPC transport. Abolishes LPC transport; when associated with A-96.
Sodium-dependent lysophosphatidylcholine symporter 1
Almost complete loss of binding to G(o) alpha subunit. No inhibition of GTPase activity.
No MAPK8IP1 nor APBA1 nor APBB1 nor DAB1 binding.
No MAPK8IP1 nor APBA1 nor Dab1 binding. No effect on APBB1 binding.
Phosphothreonine; by CDK5 and MAPK10 and LRRK2
Required for the interaction with KIF5B and for anterograde transport in axons
YENPXY motif; contains endocytosis signal
RING-type E3 ubiquitin-protein ligase PPIL2
Chromatin modification-related protein MEAF6
Faster electrophoretic migration typical of a size reduction probably due to glycosylation loss.
Faster electrophoretic migration typical of a size reduction probably due to glycosylation loss. Abolishes proteolytic cleavage.
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Katanin p60 ATPase-containing subunit A-like 2
O-linked (Xyl...) (heparan sulfate) serine
Heterogeneous nuclear ribonucleoprotein D0
Fanconi anemia core complex-associated protein 100
Tumor necrosis factor ligand superfamily member 4
Loss of protein-cysteine S-palmitoyltransferase activity.
Abolishes localization to microtubules minus ends; decreases ASPM localization to microtubules minus ends; no enhancement of ASPM activity in blocking microtubule minus-end growth.
Disrupts KATNA1:KATNB1 interaction with ASPM.
Disrupts KATNA1:KATNB1 interaction with ASPM; abolishes localization to microtubules minus ends; decreases ASPM localization to microtubules minus ends; no enhancement of ASPM activity in blocking microtubule minus-end growth.
Katanin p80 WD40 repeat-containing subunit B1
Essential for specifying initiation versus elongation step of the polyglutamylase activity
Interchain (between heavy and light chains)
Mannan-binding lectin serine protease 1 heavy chain
Mannan-binding lectin serine protease 1 light chain
A-kinase anchor protein 10, mitochondrial
Homozygous mice have their visual function which is severely reduced, consistent with significant loss of retinal ganglion cells and degeneration of axons in the optic nerve. They also display a severe multi-systemic disease characterized by reduced lifespan (<4 months), decreased weight, dilated cardiomyopathy, extrapyramidal dysfunction and gross neuro-muscular defects.
External hydrophobic patch (EHP); regulates polymerization into filaments
Flexible ZP-N/ZP-C linker; important for secretion and polymerization into filaments
BAG family molecular chaperone regulator 3
Tyrosine-protein phosphatase non-receptor type substrate 1
Ral guanine nucleotide dissociation stimulator-like 3
Zinc finger MYND domain-containing protein 15
Required for suppression of NFATC1-mediated transcription
Abolishes localization to mitochondria in fat cells.
Does not inhibit interaction with PDE6D.
Does not reduce the interaction with RP2.
Inhibits RP2-dependent GTP-hydrolysis rate.
Reduces the interaction with RP2; when associated with A-164.
Reduces the interaction with RP2; when associated with A-168.
Nuclear export signal; masked by the interaction with BRCA2
Necessary and sufficient for inhibition of PRC2/EED-EZH1 and PRC2/EED-EZH2 complex activity
Pogo transposable element with KRAB domain
Transient receptor potential cation channel subfamily V member 3
Deubiquitinating enzyme MINDY-3/4 conserved
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
Formation of unusual long bridge-like intermediate filament structures between two daughter cells during cytokinesis; when associated with A-60. Increased formation of unusual long bridge-like intermediate filament structures between two daughter cells during cytokinesis; when associated with A-32 and A-60.
Formation of unusual long bridge-like intermediate filament structures between two daughter cells during cytokinesis; when associated with A-76. Increased formation of unusual long bridge-like intermediate filament structures between two daughter cells during cytokinesis; when associated with A-32 and A-76.
Increases protein decay. forms subsarcolemmal aggregates. Changes the subcellular localization and turnover of its direct, extrasarcomeric binding partners. Knockin mice develop age-dependent desmin-positive protein aggregation pathology, skeletal muscle weakness, dilated cardiomyopathy, as well as cardiac arrhythmias and conduction defects. Knockin mice exhibit altered axial myofibrillar lattice arrangement in fast- and slow-twitch muscle fibers, increased axial stiffness and stretch-induced vulnerability in soleus muscle fiber bundles, reduced Ca(2+)-sensitivity in heterozygous fiber bundles and increased Ca(2+)-sensitivity in homozygous fiber bundles.
Reduced phosphorylation and formation of unusual long bridge-like intermediate filament structures between two daughter cells during cytokinesis. Almost complete loss of phosphorylation; when associated with A-7 and A-28. Increased formation of unusual long bridge-like intermediate filament structures between two daughter cells during cytokinesis; when associated with A-60 and A-76.
Reduced phosphorylation. Almost complete loss of phosphorylation; when associated with A-28 and A-32.
Reduced phosphorylation. Almost complete loss of phosphorylation; when associated with A-7 and A-32.
Cyclic nucleotide-gated olfactory channel
Connector enhancer of kinase suppressor of ras 3
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
LHFPL tetraspan subfamily member 1 protein
Abolishes myristoylation and membrane association.
Abolishes tyrosine phosphorylation and interactions with GRB2 and PTPN11; when associated with F-196; F-306; F-349 and F-392.
Abolishes tyrosine phosphorylation and interactions with GRB2 and PTPN11; when associated with F-196; F-306; F-349 and F-436.
Abolishes tyrosine phosphorylation and interactions with GRB2 and PTPN11; when associated with F-196; F-306; F-392 and F-436.
Abolishes tyrosine phosphorylation and interactions with GRB2 and PTPN11; when associated with F-196; F-349; F-392 and F-436.
Abolishes tyrosine phosphorylation and interactions with GRB2 and PTPN11; when associated with F-306; F-349; F-392 and F-436.
Fibroblast growth factor receptor substrate 2
2-oxoglutarate dehydrogenase complex component E1
Recognized by alloreactive CD8 cytotoxic T-lymphocytes in association with a class I MHC protein
CKLF-like MARVEL transmembrane domain-containing protein 3
Inhibition of VEGF-induced VEGFR2 signaling. Inhibition of endothelial cell migration.
Cation channel sperm-associated protein 1
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Arf-GAP domain and FG repeat-containing protein 1
Zinc finger BED domain-containing protein 6
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
Pyrin and HIN domain-containing protein 1-like
SET and MYND domain-containing protein 4
Tumor necrosis factor receptor superfamily member 26
Palmitoyl-protein thioesterase ABHD10, mitochondrial
Abolishes nuclear localization; when associated with A-324.
Abolishes nuclear localization; when associated with A-330.
Abolishes phosphorylation and RNA-binding; when associated with F-285; F-288; F-290 and F-292.
Abolishes phosphorylation and RNA-binding; when associated with F-285; F-288; F-290 and F-303.
Abolishes phosphorylation and RNA-binding; when associated with F-285; F-288; F-292 and F-303.
Abolishes phosphorylation and RNA-binding; when associated with F-285; F-290; F-292 and F-303.
Abolishes phosphorylation and RNA-binding; when associated with F-288; F-290; F-292 and F-303.
Asymmetric dimethylarginine; by CARM1; alternate
In qk-Kt4; induces embryonic lethality possibly due to its inability to homodimerize.
In qk-k24; induces embryonic lethality possibly due to blood vessel defects; prevents RNA-binding but not homodimerization.
KH domain-containing RNA-binding protein QKI
Qua1 domain; involved in homodimerization
Abolishes enzyme activity; when associated with A-281.
Abolishes enzyme activity; when associated with M-287.
Long-chain-fatty-acid--CoA ligase ACSBG1
Leucine-rich repeat-containing protein 37 N-terminal
Necessary and sufficient for homooligomerization and localization to centrosomes and pericentriolar satellites
Cilia- and flagella-associated protein 221
Phosphatidylinositol-glycan biosynthesis class W protein
Glycosyltransferase 8 domain-containing protein 2
Granulocyte-macrophage colony-stimulating factor
Zinc finger FYVE domain-containing protein 26
Enhances pro-apoptotic activity; no phosphorylation.
Enhances pro-apoptotic activity; no phosphorylation; interacts with Bcl-X(L).
No pro-apoptotic activity, no interaction with Bcl-X(L).
No pro-apoptotic activity; even when associated with A-112.
Phosphoserine; by PKA, PKB, PAK1, RPS6KA1, RPS6KB1 and PKC/PRKCQ
Phosphoserine; by PKA, PKB, PIM2, PIM3, PAK1, PAK2, PAK4, PAK5, RPS6KA1 and RAF1
Required and sufficient for interaction with KDM1A
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial
Diphosphoinositol polyphosphate phosphohydrolase 1
Loss of diphosphoinositol polyphosphate phosphohydrolase activity, but retains ability to regulate the ERK1/2 pathway.
Sufficient for mitochondrial localization
Acyl-CoA-binding domain-containing protein 7
Interphotoreceptor matrix proteoglycan 1
Loss of E3 ubiquitin protein ligase activity.
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Important for the conversion from active R-state to inactive T-state in the presence of AMP
Abolishes phosphatidate phosphatase activity but does not prevent membrane association nor coactivator activity.
Abolishes phosphatidate phosphatase activity but does not prevent membrane association.
Abolishes nuclear localization. Inhibits development of ataxia.
Abolishes DNA-binding and transactivator/repressor activity; when associated with I-407.
Abolishes DNA-binding and transactivator/repressor activity; when associated with P-383.
26S proteasome non-ATPase regulatory subunit 10
Involved in the binding to lipid droplets
Patatin-like phospholipase domain-containing protein 7
SPRY domain-containing SOCS box protein 1
Binding to HIV-1 Tat similar to human CCNT1.
Electron transfer flavoprotein beta subunit lysine methyltransferase
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Epidermal growth factor receptor kinase substrate 8-like protein 2
Disruption of its microtubule-binding and microtubule bundling activities. Failure to rescue ciliary central apparatus formation in SPEF1-depleted ependymal cilia.
Essential for homodimerization and microtubule bundling activity
Eukaryotic translation initiation factor 3 subunit I
Mitogen-activated protein kinase kinase kinase 11
Phosphoserine; by autocatalysis and MAP4K1
Required for E3 UFM1-protein ligase activity
Signal peptide, CUB and EGF-like domain-containing protein 3
Binding of alpha-amino group of substrate
In isoform VEGF-1, isoform VEGF-2, isoform VEGF-3, isoform VEGF-4 and isoform VEGF-5.
Vascular endothelial growth factor A, long form
Zinc finger and BTB domain-containing protein 20
Histone-lysine N-methyltransferase SETD1A
Cytochrome c oxidase subunit 5A, mitochondrial
Glycine cleavage T-protein C-terminal barrel
Glucocorticoid-induced transcript 1 protein
NACHT, LRR and PYD domains-containing protein 4A
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Secretion-regulating guanine nucleotide exchange factor
Inositol 1,4,5-trisphosphate receptor type 3
Dyslexia-associated protein KIAA0319-like protein
Testicular spindle-associated protein SHCBP1L
Phosphothreonine; by MAPK1, MAPK3 and MAPK8
Transactivation domain C (highly charged)
Abolishes the interaction with RAP6A and localization to Golgi membrane.
Abolishes the interaction with RAP6A and localization to Golgi membrane; when associated with Ala-935.
Abolishes the interaction with RAP6A and localization to Golgi membrane; when associated with Ser-932.
Reduces GRIA1 recycling. Abolishes the increase of spine density and size, as well as reduces the increase of GRIA1 expression in surface associated with long-term potentiation.
Loss of SLC9A3R2 binding and reduced nuclear localization. Partial recovery of nuclear accumulation; when associated with A-89.
Loss of YWHAZ binding with increased nuclear localization. Partial recovery of nuclear accumulation; when associated with deletion of 392-L--L-395.
WW domain-containing transcription regulator protein 1
Decreased ability to promote PGE2-EP4-mediated inhibition of inflammation; when associated with A-108.
Decreased ability to promote PGE2-EP4-mediated inhibition of inflammation; when associated with A-608.
Rho guanine nucleotide exchange factor 9
Interacts with PDLIM4. Loss of interaction with PTPN13.
Transcription elongation factor A protein-like 9
Abolishes interaction with DOK proteins.
Extracellular cell-membrane anchored RET cadherin 120 kDa fragment
Proto-oncogene tyrosine-protein kinase receptor Ret
Actin-related protein 2/3 complex subunit 5
Zinc finger CCCH domain-containing protein 10
Germinal center-associated signaling and motility protein
Cartilage intermediate layer protein 1 C1
Cartilage intermediate layer protein 1 C2
Structural maintenance of chromosomes protein 3
Mimics phosphorylation, unable to incorporate into microtubules.
POU domain, class 3, transcription factor 2
Cysteine sulfenic acid (-SOH); alternate
Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin); alternate
Required for the recognition of 25-hydroxycholesterol
Transcription cofactor vestigial-like protein 4
Tyrosine-protein phosphatase non-receptor type 9
Mitotic interactor and substrate of PLK1
Biogenesis of lysosome-related organelles complex 1 subunit 3
C-terminal domain; mediates TORC1 regulation
Cysteine sulfenic acid (-SOH) intermediate
N-terminal domain; may mediate the alkylhydroperoxide reductase activity
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
Coiled-coil domain-containing protein 8 homolog
PxLPxI/L motif; mediates interaction with ANKRA2
Killer cell lectin-like receptor subfamily E member 1
Mitogen-activated protein kinase kinase kinase kinase 2
non-specific serine/threonine protein kinase
Glutathione S-transferase 3, mitochondrial
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)
Mediator of RNA polymerase II transcription subunit 13
Mothers against decapentaplegic homolog 2
Calcium ion selectivity and permeability
Voltage-dependent N-type calcium channel subunit alpha-1B
Loss of activity, but function in microtubule stability not affected; when associated with W-134 and P-139.
Loss of activity, but function in microtubule stability not affected; when associated with W-134 and W-136.
Loss of catalytic activity, but function in microtubule stability not affected; when associated with W-136 and P-139.
Strong reduction in tubulin acetylation, no effect on tubulin-binding; when associated with R-146; R-233 and R-244.
Strong reduction in tubulin acetylation, no effect on tubulin-binding; when associated with R-56; R-146 and R-233.
Strong reduction in tubulin acetylation, no effect on tubulin-binding; when associated with R-56; R-146 and R-244.
Strong reduction in tubulin acetylation, no effect on tubulin-binding; when associated with R-56; R-233 and R-244.
Abolishes N-terminal proteolytic processing.
Necessary for interaction with HDAC3 and transcriptional repression
Sodium-dependent phosphate transporter 1
Mediates the interaction with RAB13 and RAB35 and intramolecular interaction with the CH domain
Necessary and sufficient to associate with tubular recycling endosome membranes, mediate phosphatidic acid-binding and membrane tubulation
Fibronectin type III domain-containing protein 11
Urokinase plasminogen activator surface receptor
28S rRNA (cytosine-C(5))-methyltransferase
Voltage-dependent calcium channel gamma-4 subunit
Abolishes enzymatic activity and ubiquitin binding.
Abolishes enzymatic activity, but does not affect ubiquitin binding.
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Aldehyde dehydrogenase family 3 member B2
Trimeric intracellular cation channel type B
No effect on cooperative binding with PBX1 to CYP17.
Actin, cytoplasmic 2, N-terminally processed
N-acetylglutamate; in Actin, cytoplasmic 2, N-terminally processed
Nuclear protein localization protein 4 homolog
Phospho-regulated basic and hydrophobic (PRBH) motif
S-Lysyl-methionine sulfilimine (Lys-Met) (interchain with M-1533)
S-Lysyl-methionine sulfilimine (Met-Lys) (interchain with K-1651)
Bicarbonate transporter-like transmembrane
DRY motif; important for ligand-induced conformation changes
NPxxY motif; important for ligand-induced conformation changes and signaling
WD repeat domain phosphoinositide-interacting protein 3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Biopterin-dependent aromatic amino acid hydroxylase family profile
Loss of interaction with EGFR and FLT3. No effect on E3 ubiquitin protein ligase activity; when associated with A-22.
Loss of interaction with EGFR and FLT3. No effect on E3 ubiquitin protein ligase activity; when associated with A-25.
Nuclear envelope phosphatase-regulatory subunit 1
Phosphotyrosine; by FGFR1, ABL1, FLT3 and JAK2
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
Coiled-coil domain-containing protein 117
ATPase family AAA domain-containing protein 3
Required for interaction with the inner surface of the mitochondrial outer membrane
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
Peptide (Met-Gly) (interchain with G-Cter in ubiquitin)
Abolishes the decapping activity on both incomplete m7G cap and NAD-cap RNAs.
Abolishes the decapping activity on both incomplete m7G cap and NAD-cap RNAs. Abolishes the 5'-3' exoribonuclease activity.
Processed beta-1,4-galactosyltransferase 1
Gamma tubulin complex component C-terminal
Gamma tubulin complex component protein N-terminal
Serine/threonine-protein kinase greatwall
Hsp90 co-chaperone Cdc37, N-terminally processed
N-acetylvaline; in Hsp90 co-chaperone Cdc37, N-terminally processed
Mitochondrial carnitine/acylcarnitine carrier protein
Dehydrogenase/reductase SDR family member 13
Sterile alpha motif domain-containing protein 1
Essential for loading of BUBR1, MAD1L1 and MAD2L1 to kinetochores
Mitotic checkpoint serine/threonine-protein kinase BUB1
Abolishes the formation of a preferential cleavage product. Abolishes protein cleavage; when associated with G-579.
Abolishes the formation of an alternative cleavage product. Abolishes protein cleavage; when associated with G-510.
Decreases CDERNA-binding. Increases target-mRNA expression.
Failed to reduce poly(A) tailed ICOS mRNA. Failed to regulate the production of inflammatory cytokines.
In sanroque; partial loss of ICOS regulation, no effect on localization to stress granules, no effect on RNA-binding.
No effect on localization to stress granules, reduces RNA-binding.
No effect on localization to stress granules.
Slightly decreases CDE and ADERNA-binding.
Strongly decreases CDE and ADERNA-binding.
Strongly decreases CDE and ADERNA-binding. Increases target-mRNA expression. Abolishes CDERNA-binding and highly increases target-mRNA expression; when associated with A-239. Increases target-mRNA expression. Increases ICOS surface expression; when associated with A-220 and A-239.
Strongly decreases CDE and ADERNA-binding. Increases target-mRNA expression. Abolishes CDERNA-binding and highly increases target-mRNA expression; when associated with A-260. Increases target-mRNA expression. Increases ICOS surface expression; when associated with A-220 and A-260.
Strongly decreases CDE and ADERNA-binding. Increases target-mRNA expression. Increases ICOS surface expression; when associated with A-239 and A-260.
C-terminal inhibitory domain; interacts with PCSK1
Discoidin, CUB and LCCL domain-containing protein 1
Ankyrin repeat domain-containing protein 2
Neuronal acetylcholine receptor subunit alpha-3
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Galactose-1-phosphate uridylyltransferase
Inhibits lipid kinase activity. Mice are viable and fertile but display defective adaptive and innate immune responses Signaling defects in B-cells, T-cells, mast cells and natural killer cells. Reduced B and T-cell receptor signaling. Affects development and differentiation of B -ells. Reduced memory T-cell number. Affects B- and T-cell proliferation. Attenuates immune responses in vivo. Induces inflammatory bowel disease development. Lost TCR-induced migration and localization to antigenic tissue. Affects natural killer cell maturation and cytokine production.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Ubiquitin carboxyl-terminal hydrolase 32
Chromosome transmission fidelity protein 8 homolog
Decreased expression in renal and prostate cancer protein
SKI family transcriptional corepressor 2
Reduced sumoylation levels. No effect on DNA-binding and slight reduction of transcriptional repression. Abolishes sumoylation. No effect on DNA-binding but great reduction in transcriptional repression; when associated with A-197.
Reduced sumoylation levels. No effect on DNA-binding and slight reduction of transcriptional repression. Abolishes sumoylation. No effect on DNA-binding but great reduction of transcriptional repression; when associated with A-10.
Slight reduction of transcriptional repression. Great reduction of transcriptional repression; when associated with A-199.
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Necessary for tumor-suppressive function
Polypeptide N-acetylgalactosaminyltransferase 5
Constitutively active. Interacts with GARIN1B.
Constitutively inactive. Loss of Golgi apparatus location. Loss of interaction with GARIN1B.
Coiled-coil domain-containing protein 142
Abolishes DNA-binding and transcriptional activity.
Abolishes monomethylation by SETD6 and interaction with EHMT1.
Abolishes sulfhydration and impairs interaction with RPS3.
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3); alternate
N6-acetyllysine; by PCAF and EP300; alternate
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Rho guanine nucleotide exchange factor 37
Contributes to high-affinity binding to cocaine
Functional dopamine transporter with 4-fold decrease in cocaine sensitivity.
Retention of dopamine transporter activity and high sensitivity to cocaine.
Distal membrane-arm assembly complex protein 2
Oxysterol-binding protein-related protein 9
Double-stranded RNA-binding protein Staufen homolog 1
Gamma-aminobutyric acid receptor subunit rho-1
Leucine-rich PPR motif-containing protein, mitochondrial
Mediates interaction with STAT2 (and required for the recruitment of USP18)
Activation domain; required for transcription activation
Decreased phosphorylation, leading to decreased autoinhibition. Strongly decreased phosphorylation, leading to stongly decreased autoinhibition; when associated with 282-A--A-285.
Decreased phosphorylation, leading to decreased autoinhibition. Strongly decreased phosphorylation, leading to stongly decreased autoinhibition; when associated with A-251.
Does not affect phosphorylation and autoinhibition.
Pleckstrin homology domain-containing family J member 1
Rap guanine nucleotide exchange factor-like 1
PCNA-interaction protein motif (PIP box)
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
Leucine-rich repeat-containing protein 71
Loss of kinase activity and changed localization in the nucleus.
Elongation of very long chain fatty acids protein 7
Serologically defined colon cancer antigen 8 homolog
Impairs autoinhibition; when associated with A-385. Impairs translocation to the cell membrane.
Impairs autoinhibition; when associated with A-389. Impairs translocation to the cell membrane.
Increases guanine exchange factor activity.
Necessary for localization at adherens junction
G-protein coupled receptors family 1 profile domain-containing protein
Ribonuclease A-domain domain-containing protein
Class E basic helix-loop-helix protein 22
Lipolysis-stimulated lipoprotein receptor
Glutathione S-transferase C-terminal domain-containing protein
Rho family-interacting cell polarization regulator 1
NACHT, LRR and PYD domains-containing protein 9A
Membrane-spanning 4-domains subfamily A member 4D
Asymmetric dimethylarginine; by PRMT6; alternate
Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5
Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
Mimics phosphorylation; knockin mice show a significant level of resistance to PIM1 inhibitors.
Cystic fibrosis transmembrane conductance regulator
Impairs protein folding, due to small local changes that probably disrupt crucial interactions with the transmembrane domain. Abolishes normal maturation. Impairs trafficking to the apical cell membrane.
Abolished ability to acylate ghrelin. Does not affect proteic cleavage. loss of serine O-acyltransferase activity.
No effect on ability to acylate ghrelin.
Mitogen-activated protein kinase kinase kinase 19
Caspase recruitment domain-containing protein 19
Phosphorylase b kinase regulatory subunit alpha, liver isoform
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
Zinc finger SWIM domain-containing protein 8
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
Synapse differentiation-inducing gene protein 1
Important for interaction with G proteins
Parathyroid hormone/parathyroid hormone-related peptide receptor
In knockin mouse model, decreases protein levels. Mice exhibit a short sleep phenotype. Changes the electrophysiological properties of dorsal pons neurons.
Pituitary tumor-transforming gene 1 protein-interacting protein
Abolishes histone methyltransferase activity and subsequent repression. In GM3; does not form heterodimer with EHMT1 and is defective in mediating both H3K9me and DNA methylation.
Histone-lysine N-methyltransferase EHMT2
In GM4; defective in methyltransferase activity without affecting DNA methylation.
In GM6; does not form heterodimer with EHMT1 and is defective in mediating H3K9me.
In GM7; defective in methyltransferase activity without affecting DNA methylation; when associated with F-1207.
In GM7; defective in methyltransferase activity without affecting DNA methylation; when associated with V-1120.
N6,N6,N6-trimethyllysine; by EHMT2; alternate
N6,N6-dimethyllysine; by EHMT2; alternate
Strongly reduces histone methyltransferase activity.
Low affinity immunoglobulin epsilon Fc receptor
CD2 antigen cytoplasmic tail-binding protein 2
Modulates macrophage cytokine secretion.
No effect on macrophage cytokine secretion.
N-acetylthreonine; in Histone H1.0, N-terminally processed
Transcription elongation factor A protein 3
V-set domain containing T-cell activation inhibitor 1
Interleukin-3 receptor class 2 subunit beta
Inhibits receptor signaling in absence of type IV collagen
Mediates interaction with type IV collagen
tRNA-splicing endonuclease subunit Sen15
Inositol polyphosphate 5-phosphatase OCRL
G-protein coupled receptor family C group 5 member C
Loss of interaction with EGFR and FLT3. No effect on E3 ubiquitin protein ligase activity but alters specificity for 'Lys-48'-linked chains; when associated with A-13.
Loss of interaction with EGFR and FLT3. No effect on E3 ubiquitin protein ligase activity but alters specificity for 'Lys-48'-linked chains; when associated with A-16.
Aminoacyl-transfer RNA synthetases class-II family profile
Phenylalanine--tRNA ligase, mitochondrial
26S proteasome non-ATPase regulatory subunit 7
SH2-like; required for interaction with growth factor receptors
Abolishes downstream phosphorylation of CBL and VAV1; when associated with F-266, F-325 and F-344.
Abolishes downstream phosphorylation of CBL and VAV1; when associated with F-266, F-325 and F-369.
Abolishes downstream phosphorylation of CBL and VAV1; when associated with F-266, F-344 and F-369.
Abolishes downstream phosphorylation of CBL and VAV1; when associated with F-325, F-344 and F-369.
Decreases downstream phosphorylation of CBL and VAV1.
Weakly decreases downstream phosphorylation of CBL and VAV1; when associated with F-325 and F-344.
Weakly decreases downstream phosphorylation of CBL and VAV1; when associated with F-325 and F-369.
Weakly decreases downstream phosphorylation of CBL and VAV1; when associated with F-344 and F-369.
Important for C5-methylcytosine-recognition
5-demethoxyubiquinone hydroxylase, mitochondrial
Loss of interaction with clathrin heavy chains.
Alanine and arginine-rich domain-containing protein
Serine/threonine-protein kinase receptor R3
Dephenylalaninated tubulin alpha-8 chain
Does not affect transcription factor activity.
In Mut1; reduced transcription factor activity.
In Mut2; strongly reduced transcription factor activity.
Knockin mice are significantly smaller and die immediately after birth. They show a partially truncated mandible and fusion of the upper and lower jaws (syngnathia) and anomalies of various bones of the ear.
Knockin mice hemizygous for L-218 mutant and a deletion of the wild-type Foxi3 allele fail to thrive after birth, are underweight, display respiratory abnormalities and die between birth and day 5.
Reduced endocytosis; when associated with F-783.
Reduced endocytosis; when associated with F-795.
Signal for sorting from recycling endosomes; interaction with ACAP1
Cyclic AMP-dependent transcription factor ATF-6 alpha
Processed cyclic AMP-dependent transcription factor ATF-6 alpha
Required for inhibition of CAPN3 protease activity
SUMO interaction motif 1 (SIM); mediates the binding to polysumoylated substrates
SUMO interaction motif 2 (SIM); mediates the binding to polysumoylated substrates
SUMO-interacting motif-containing protein 1
In isoform 3, isoform 4, isoform 5 and isoform 6.
In strain: C57BL/6J, A/HeJ and SPRET/Ei.
In strain: SWR/J, AKR/J, RBF/DNJ and P/J.
Small conductance calcium-activated potassium channel protein 1
Geranylgeranyl transferase type-2 subunit alpha
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
In wim; embryos arrest at 10.5-11.5 dpc and display an open neural tube in the head that lack the normal groove on the ventral midline. They lack ventral neural cell types and display other phenotypes characteristic of defects in Sonic hedgehog signaling.
Intraflagellar transport protein 172 homolog
Disruption of phosphorylation by MAPK and GSK3B, acquisition of DNA-binding activity and transactivation function; when associated with A-179 and A-184.
Disruption of phosphorylation by MAPK and GSK3B, acquisition of DNA-binding activity and transactivation function; when associated with A-179 and A-188.
Disruption of phosphorylation by MAPK and GSK3B, acquisition of DNA-binding activity and transactivation function; when associated with A-184 and A-188.
Dominant negative. Loss of transactivation activity. No effect on interaction with EP300.
Highly increases transactivation activity; when associated with A-180.
Highly increases transactivation activity; when associated with A-181.
Loss of hepatocyte proliferation induction by TGFA.
N6-acetyllysine; by KAT2A and KAT2B; alternate
No effect on transactivation activity. Not acetylated after glucocorticoid-stimulation and no increase of transactivation activity; when associated with R-101 and R-102.
Not acetylated after glucocorticoid-stimulation and no increase of transactivation activity; when associated with R-98 and R-102.
Not acetylated and no increase of transactivation activity after glucocorticoid-stimulation; when associated with R-98 and R-101.
Not sumoylated. Decreases ubiquitination and increases stability. Loss of proliferation inhibition in T cells. No effect on transactivation activity.
Phosphothreonine; by RPS6KA1 and PKC/PRKCA
Phosphothreonine; by RPS6KA1, CDK2 and MAPK
Reduces phosphorylation in response to calcium.
Required for MYC transcriptional repression
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
RUN and FYVE domain-containing protein 2
Cleavage and polyadenylation specificity factor subunit 2
Large ribosomal subunit protein uL3-like
Baculoviral IAP repeat-containing protein 2
Important for formation of active hexamer structure
In lzme; causes arrest of embryonic development during gastrulation due to chondroitin sulfate and heparan sulfate deficiency, impaired FGF signaling and impaired migration of mesoderm and endoderm.
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Serine/threonine-protein phosphatase CPPED1
Uncharacterized protein C14orf93 homolog
Inositol polyphosphate-4-phosphatase type I A
Immediate early response gene 5-like protein
Ubiquitin-activating enzyme E1 C-terminal
Ubiquitin-like modifier-activating enzyme 1
No effect on homodimerization. Abolishes homodimerization; when associated with E-444.
Reduced phosphorylation. No nuclear entry PER1, CRY1 nor CKSN1E; when associated with A-661.
Reduced phosphorylation. No nuclear entry of PER1, CRY1 nor CKSN1E; when associated with A-663.
Reduces homodimerization. Abolishes homodimerization; when associated with E-267.
Mitochondrial genome maintenance exonuclease 1
Guanine nucleotide-binding protein G(i) subunit alpha-1
Abolishes interaction with the elongin BC complex.
Elongin BC and Polycomb repressive complex 2-associated protein
Golgi associated RAB2 interactor protein-like Rab2B-binding
ATP synthase subunit beta, mitochondrial
Leucine-rich repeat-containing protein 19
Ubiquitin-conjugating enzyme E2Q-like protein 1
ATP-binding cassette sub-family C member 5
His-rich loop; required for zinc transport
Eukaryotic translation initiation factor 3 subunit E
Sprouty-related, EVH1 domain-containing protein 1
Loss of ability to regulate activity of mitochondrial respiratory chain complexes.
Abolishes production of IL1B in response to bacterial flagellin.
Baculoviral IAP repeat-containing protein 1e
Mildly reduced interaction with flagellin.
Nearly abolishes interaction with flagellin.
No effect on production of IL1B in response to bacterial flagellin.
Strongly reduced interaction with flagellin.
Strongly reduces production of IL1B in response to bacterial flagellin.
Strongly reduces production of IL1B in response to bacterial flagellin; then associated with F-15.
Strongly reduces production of IL1B in response to bacterial flagellin; then associated with I-11.
Immunoglobulin V-set domain-containing protein
Metallophosphoesterase domain-containing protein 1
A disintegrin and metalloproteinase with thrombospondin motifs 1
Spermatogenesis-associated protein 2-like protein
Double-strand-break repair protein rad21 homolog
Rad21/Rec8-like protein C-terminal eukaryotic
Transmembrane emp24 domain-containing protein 4
No loss of interaction with SPSB4; when associated with F-596.
No loss of interaction with SPSB4; when associated with F-602.
RCC1 and BTB domain-containing protein 1
Ankyrin repeat and SAM domain-containing protein 3
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Suppressor of tumorigenicity 14 protein homolog
Intramolecular interaction with C-terminus
Intramolecular interaction with N-terminus
Voltage-gated potassium channel subunit beta-1
Serine/threonine-protein kinase 3 20kDa subunit
Serine/threonine-protein kinase 3 36kDa subunit
Recombining binding protein suppressor of hairless-like protein
Ubiquitin carboxyl-terminal hydrolase 37
Double C2-like domain-containing protein gamma
Large ribosomal subunit protein uL4 C-terminal
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Lysosomal cobalamin transport escort protein LMBD1
Significantly reduced interaction with adapter protein complex 2 and disruption of its function in clathrin-mediated endocytosis of INSR.
WTKF motif; mediates interaction with adapter protein complex 2 and is essential for its function in clathrin-mediated endocytosis of INSR
YERL motif; mediates interaction with adapter protein complex 2 and is essential for its function in clathrin-mediated endocytosis of INSR
In strain: DBA/2, NZB and NZW, in vitro decreases nuclease activity against free DNA by approximately twofold and decreases activity to establish a barrier to liposomal gene transfection by eightfold.
Not required for free DNA-nuclease activity but required for activity towards liposome-coated DNA
Ubiquitin carboxyl-terminal hydrolase 48
Abolishes the nuclear speckle localization but not the nuclear localization.
Does not affect the subcellular localization.
Natural resistance-associated macrophage protein 2
Glycerol-3-phosphate dehydrogenase, mitochondrial
Cyclin-D-binding Myb-like transcription factor 1
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
GTP cyclohydrolase 1 feedback regulatory protein
Transport and Golgi organization 2 homolog
G protein-activated inward rectifier potassium channel 4
Coiled-coil domain-containing protein 167
Trafficking protein particle complex subunit 13
Meiotic recombination protein DMC1/LIM15 homolog
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Amyloid beta precursor protein binding family B member 2
Abolished ubiquitination by the BCR(KLHL25)complex, leading to imapired differentiation of inducible regulatory T (iTreg) cells; when associated with R-530 and R-536.
Abolished ubiquitination by the BCR(KLHL25)complex, leading to imapired differentiation of inducible regulatory T (iTreg) cells; when associated with R-530 and R-544.
Abolished ubiquitination by the BCR(KLHL25)complex, leading to imapired differentiation of inducible regulatory T (iTreg) cells; when associated with R-536 and R-544.
Phosphoserine; by PKA and PKB/AKT1 or PKB/AKT2
Trafficking kinesin-binding protein C-terminal
Platelet-derived growth factor subunit A
Required for association with membranes and function in neurite spine formation
Abolishes IFNB1 production upon infection with various viruses.
U3 small nucleolar ribonucleoprotein protein IMP4
U6 snRNA-associated Sm-like protein LSm1
Allows binding to CUL1 and RBX1 and formation of an authentic SCF (SKP1-CUL1-F-box protein) complex.
Peptidyl-prolyl cis-trans isomerase FKBP2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Amyloid-beta A4 precursor protein-binding family A member 3
Required for interaction with NRXN1 (via C-terminal tail)
Biogenesis of lysosome-related organelles complex 1 subunit 6
In strain: BALB/c, CBA and C57BL/6J-pa mutants.
Interchain (with C-33 in TGFB1); in linked form
Latent-transforming growth factor beta-binding protein 4
Abolishes the binding to CDK5RAP1, CDK5RAP2, CDKRAP3, but not to CDK5.
Cyclin-dependent kinase 5 activator 1, p25
Cyclin-dependent kinase 5 activator 1, p35
Required for TMED10 and TMED2 cis-Golgi network localization
Transmembrane emp24 domain-containing protein 10
Loss of activity. Does not affect the interaction with SBF2/MTMR13.
Loss of interaction with SBF2/MTMR13 which results in a decrease in SBF2/MTMR13 localization to membranes.
Severely impaired interaction with membranes and strongly reduced catalytic activity.
Normal response to light but reduced retinal electrical activity in response to light in dark adapted retinas. Gross morphology is normal.
Ankyrin repeat and EF-hand domain-containing protein 1
Mediator of RNA polymerase II transcription subunit 11
in ADMIDAS binding site and liganded-open conformation
in ADMIDAS binding site and unliganded-closed conformation
Loss of function in histone modification.
Loss of function in histone modification. Loss of nuclear localization.
Putative histone-lysine N-methyltransferase PRDM6
Cell division cycle and apoptosis regulator protein 1
von Willebrand factor A domain-containing protein 8
Conserved oligomeric Golgi complex subunit 5
Coiled-coil-helix-coiled-coil-helix domain-containing protein 5
IMS import disulfide relay-system CHCH-CHCH-like Cx9C
Zinc finger Ran-binding domain-containing protein 2
Thymocyte selection-associated high mobility group box protein TOX
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
Ras GTPase-activating protein-binding protein 2
10 X 4 AA tandem repeats of S-P-[RGMKC]-[RK]
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3
Required for interaction with PFN1, HER2, and ATG12
Prolyl-tRNA synthetase associated domain-containing protein 1
Necessary for binding to the m3G-cap structure
Necessary for interaction with KPNB1 and m3G-cap U1 and U5 snRNP import receptor activity
Decreased MCM complex DNA helicase activity. Loss of ATP-binding. Decreased MCM complex ATPase activity. No effect on MCM complex formation.
Loss of MCM complex DNA helicase activity. Loss of ATP-binding. No effect on MCM complex formation. No effect on MCM complex ATPase activity and ssDNA binding.
DAP3-binding cell death enhancer 1 short form
Interchain (with C-577 in SUN2); alternate
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Zinc finger CCHC domain-containing protein 18
O-glycosylated at seven sites with GalNAc
Does not abolish interaction with RXRIP110.
Nuclear receptor subfamily 6 group A member 1
Does not inhibit interaction with TTI1 or TTI2. Inhibits weakly interaction with TTI1 or TTI2; when associated with E-407 or R-424. Inhibits interaction with TTI1 or TTI2; when associated with E-407 and R-424.
Does not inhibit interaction with TTI1 or TTI2. Inhibits weakly interaction with TTI1 or TTI2; when associated with Q-395 or E-407. Inhibits interaction with TTI1 or TTI2; when associated with Q-395 and E-407.
Does not inhibit interaction with TTI1 or TTI2. Inhibits weakly interaction with TTI1 or TTI2; when associated with Q-395 or R-424. Inhibits interaction with TTI1 or TTI2; when associated with Q-395 and R-424.
Telomere length regulation protein TEL2 homolog
von Willebrand factor A domain-containing protein 5B2
Hydroxyacid-oxoacid transhydrogenase, mitochondrial
Reduces transcriptional activation; when associated with A-53.
Reduces transcriptional activation; when associated with A-56.
RNA-binding motif, single-stranded-interacting protein 1
2-oxoadipate dehydrogenase complex component E1
Isopentenyl-diphosphate Delta-isomerase 1
Inhibits DNA-binding activity and transcriptional activation of NEUROD1 expression.
Interaction with phosphoserine on interacting protein
Protein mono-ADP-ribosyltransferase PARP10
Keratinocyte differentiation-associated protein
Rho guanine nucleotide exchange factor 25
Chromodomain-helicase-DNA-binding protein 7
Aspartate 1-(chondroitin 4-sulfate)-ester
Inter-alpha-trypsin inhibitor heavy chain H3
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins); alternate
Guanine nucleotide-binding protein subunit beta-like protein 1
Structural maintenance of chromosomes protein 6
Intraflagellar transport protein 57 homolog
Cilia- and flagella-associated protein 69
Histone deacetylase glutamine rich N-terminal
Tyrosine-protein phosphatase non-receptor type 22
Abolishes RNA binding; when associated with L-63 and L-65.
Abolishes RNA binding; when associated with L-63 and L-68.
Abolishes RNA binding; when associated with L-65 and L-68.
Loss of interaction with EZR, MSN and RDX and co-localization to microvilli with EZR, MSN and RDX.
Required for interaction with EZR, MSN and RDX and for the co-localization to microvilli
tRNA-splicing endonuclease subunit Sen34
Ubiquitin-associated domain-containing protein 1
Cell cycle exit and neuronal differentiation protein 1
Interleukin-1 receptor-associated kinase 1-binding protein 1
Transmembrane protein TMEM132 C-terminal
Transmembrane protein TMEM132 N-terminal
In isoform PLEC-0,1C, isoform PLEC-0,1C,2A and isoform PLEC-0,1C,2A,3A.
In isoform PLEC-0,1C, isoform PLEC-0,1C,2A,3A and isoform PLEC-0,1C,2A.
In isoform PLEC-1, isoform PLEC-1A, isoform PLEC-1B, isoform PLEC-1D, isoform PLEC-1E, isoform PLEC-1G, isoform PLEC-1F and isoform PLEC-0,1C.
In isoform PLEC-1A, isoform PLEC-1B and isoform PLEC-1B,2A.
In isoform PLEC-1B and isoform PLEC-1B,2A.
In isoform PLEC-1D and isoform PLEC-1D,2A.
In isoform PLEC-1E and isoform PLEC-1E,2A.
Required for efficient interaction with KRT5 and KRT14 heterodimers
Required for interaction with intermediate filament proteins
Required for interaction with type2 keratins, DES and VIM
Class E basic helix-loop-helix protein 23
Essential for ESRRB transcriptional activity and interaction with NCOA3
Loss of self-renewal in embryonic stem cells in absence of LIF. Does not interact with NCOA3.
Loss of self-renewal in embryonic stem cells in absence of LIF; when associated with A-424. Does not interact with NCOA3; when associated with A-424.
Loss of self-renewal in embryonic stem cells in absence of LIF; when associated with A-425. Does not interact with NCOA3; when associated with A-425.
Calcium/calmodulin-dependent protein kinase type 1D
Constitutively active form; when associated with 289-A--A-292.
Constitutively active form; when associated with A-301.
Cilia- and flagella-associated protein 74
Required for nuclear location and interaction with MOV10
N-acetyllactosaminide alpha-1,3-galactosyltransferase
Does not affect autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part.
Does not affect subcellular location. Impaired DNA-binding.
Loss of trimerization; when associated with 439-E--L-441 DEL.
Loss of trimerization; when associated with R-469.
Prevents autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part.
2'-5'-oligoadenylate synthase-like protein 2
Interchain (with KASH domain-containing nesprins)
Sufficient for interaction with SYNE1 and SYNE2
Loss of in vitro ubiquitin-conjugating activity.
TPA-induced transmembrane protein homolog
Integrin alpha-2 domain-containing protein
In Jeff mutant; heterozygotes are deaf with chronic proliferative otitis media, have a shortened snout and occipital region, and are smaller than wild-type littermates. Homozygotes demonstrate perinatal lethality due to respiratory problems, are born with upper eyelids open and show clefting of the hard or soft palate as well as facial clefting.
In Mutt mutant; 13% of heterozygotes show a reduced startle response to a toneburst of 24 kHz and a mild craniofacial abnormality. 17% of homozygotes show perinatal lethality. Surviving homozygotes demonstrate a marked craniofacial abnormality and reduced hearing.
5'-AMP-activated protein kinase subunit beta-2
Leucine-rich repeat-containing protein 51
H/ACA ribonucleoprotein complex subunit 3
A disintegrin and metalloproteinase with thrombospondin motifs 16
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Abolishes interaction with MUSK and function; when associated with A-158 and A-159.
Abolishes interaction with MUSK and function; when associated with A-174.
Abolishes interaction and stabilization of BUB3.
BUB3-interacting and GLEBS motif-containing protein ZNF207
Abolishes dimerization. Weakly interacts with C1q domain of CBLN1.
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Glycylpeptide N-tetradecanoyltransferase 1
Glycylpeptide N-tetradecanoyltransferase C-terminal
Glycylpeptide N-tetradecanoyltransferase N-terminal
Mediates interaction with the P-TEFb complex
All-trans-retinol dehydrogenase [NAD(+)] ADH7
Tumor necrosis factor receptor superfamily member 22
4 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-C
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Probable E3 ubiquitin-protein ligase HECTD2
Insulin-like growth factor-binding protein 6
In prebycusis phenotype; when associated with waltzer cadherin 23 mutant.
Mediator of RNA polymerase II transcription subunit 26
Important for normal N-type inactivation
Loss of channel activity. Functions as dominant negative mutation that impairs function of wild-type channel subunits. Causes impaired Purkinje cell dendrite growth and premature death of cerebellar Purkinje cells.
No effect on voltage-dependent channel opening or current amplitude, but decreased rate of inactivation during prolonged depolarization.
Potassium voltage-gated channel subfamily C member 3
Cytoplasmic dynein 1 light intermediate chain 1
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4
Uncharacterized protein KIAA0930 homolog
Endonuclease/exonuclease/phosphatase family domain-containing protein 1
Phosphoserine; by CDC42BP, CIT, MLCK, PAK1, ROCK1, ROCK2, DAPK1, DAPK2 and ZIPK/DAPK3
Phosphothreonine; by MLCK, CIT and ROCK2
Prevents aberrant myotube formation in PIEZO1-deficient myoblast; when associated with D-19.
Prevents aberrant myotube formation in PIEZO1-deficient myoblast; when associated with D-20.
In C47 mutant; does not affect ability to mediate inflammatory response and cell death; when associated with N-296.
In C47 mutant; does not affect ability to mediate inflammatory response; when associated with 313-N-N-314.
In C60 mutant; impaired cleavage and ability to generate caspase-1 subunits p10 and p20; abolished ability to process inflammatory cytokine interleukin-1 beta (IL1B) without affecting ability to induce programmed cell death.
In C71 mutant; abolished cleavage and ability to generate caspase-1 subunits; abolished ability to process inflammatory cytokine interleukin-1 beta (IL1B) and ability to induce programmed cell death; when associated with N-103 and 296-N--N-314.
In C71 mutant; abolished cleavage and ability to generate caspase-1 subunits; abolished ability to process inflammatory cytokine interleukin-1 beta (IL1B) and ability to induce programmed cell death; when associated with N-103 and N-122.
In C71 mutant; abolished cleavage and ability to generate caspase-1 subunits; abolished ability to process inflammatory cytokine interleukin-1 beta (IL1B) and ability to induce programmed cell death; when associated with N-122 and 296-N--N-314.
Mediates autoprocessing but are unable to mediate cleavage of Gasdermin-D (GSDMD).
Abolished potassium-chloride cotransport.
Constitutively enhanced potassium-chloride cotransport activity. Significant locomotor deficits.
Loss of potassium-chloride cotransport activity in Xenopus laevis oocytes.
Reduced potassium-chloride cotransport activity in Xenopus laevis oocytes.
RCC1-like G exchanging factor-like protein
Specifically androgen-regulated gene protein
Increased autophosphorylation in the absence of PDGFB binding. Increased autophosphorylation in response to PDGFB binding. Constitutive interaction with PIK3R1, and constitutive AKT1 activation.
Platelet-derived growth factor receptor beta
Strongly reduced levels of vascular smooth muscle cells and pericytes in developing blood vessels; when associated with F-578; F-715; F-739; F-750; F-1008 and F-1020.
Strongly reduced levels of vascular smooth muscle cells and pericytes in developing blood vessels; when associated with F-578; F-715; F-739; F-750; F-770 and F-1008.
Strongly reduced levels of vascular smooth muscle cells and pericytes in developing blood vessels; when associated with F-578; F-715; F-739; F-750; F-770 and F-1020.
Strongly reduced levels of vascular smooth muscle cells and pericytes in developing blood vessels; when associated with F-578; F-715; F-739; F-770; F-1008 and F-1020.
Strongly reduced levels of vascular smooth muscle cells and pericytes in developing blood vessels; when associated with F-578; F-715; F-750; F-770; F-1008 and F-1020.
Strongly reduced levels of vascular smooth muscle cells and pericytes in developing blood vessels; when associated with F-578; F-739; F-750; F-770; F-1008 and F-1020.
Strongly reduced levels of vascular smooth muscle cells and pericytes in developing blood vessels; when associated with F-715; F-739; F-750; F-770; F-1008 and F-1020.
Mediates interaction with ESR1 and STUB1
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Protein N-lysine methyltransferase METTL21A
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
G-protein coupled receptors family 2 profile 1
Important for allosteric inhibitor binding
Results in impaired glucagon binding and glucagon-mediated signaling. Homozygous mice show hyperglucagonemia with alpha-cell hyperplasia and enlargement of the pancreas.
Calmodulin-regulated spectrin-associated protein 1
Sufficient for interaction with calmodulin
Carcinoembryonic antigen-related cell adhesion molecule 5
Trafficking protein particle complex subunit 6B
Coiled-coil domain-containing protein 171
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51
Phosphofurin acidic cluster sorting protein 2
Myb/SANT-like DNA-binding domain-containing protein 2
4 X 11 AA tandem repeats of [EGSA]-K-T-K-[EQ]-[GQ]-V-X(4)
Sodium/potassium-transporting ATPase subunit beta-1
Mitochondrial sodium/calcium exchanger protein
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
DCB; DCB:DCB domain and DCB:HUS domain interaction
Filamin 20; mediates interaction with XIRP1
Intradomain insert; mediate targeting to Z lines
tRNA wybutosine-synthesizing protein 3 homolog
PH domain leucine-rich repeat-containing protein phosphatase 1
Lysosomal amino acid transporter 1 homolog
PRELI domain-containing protein 1, mitochondrial
Required and sufficient for interaction with POMGNT1
Ribitol-5-phosphate transferase FKTN N-terminal
Oxidized purine nucleoside triphosphate hydrolase
Acetyl-CoA acetyltransferase, mitochondrial
Increases nucleophilicity of active site Cys
Platelet-activating factor acetylhydrolase
O-linked (Gal...) hydroxylysine; alternate
Sperm microtubule associated protein 2-like
C-terminal tail; required for its localization to cytoplasmic vesicle
Loss of catalytic activity and localization to cytoplasmic vesicle.
Loss of localization to cytoplasmic vesicle.
When expressed in constitutive LMOD2 knockout mice, the mutant reduces onset of cardiac dilation and dysfunction.
Sodium- and chloride-dependent GABA transporter 3
Histone acetyltransferase type B catalytic subunit
Epithelial discoidin domain-containing receptor 1
Abolishes phosphorylation. Protein preferentially localized in nucleus.
No effect on phosphorylation. Protein preferentially localized in cytoplasm.
Coiled-coil domain-containing protein 124
Zinc finger and SCAN domain-containing protein 21
For hydroxyacyl-coenzyme A dehydrogenase activity
Important for hydroxyacyl-coenzyme A dehydrogenase activity
Important for long-chain enoyl-CoA hydratase activity
Trifunctional enzyme subunit alpha, mitochondrial
RNA polymerase II-associated factor 1 homolog
Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA
Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding site
Neuronal acetylcholine receptor subunit beta-2
Coiled-coil domain-containing protein 183
Gamma-aminobutyric acid type B receptor subunit 1
Decreases sedoheptulose kinase activity.
Decreases sedoheptulose kinase activity; when associated with K-15.
Decreases sedoheptulose kinase activity; when associated with M-14.
Ankyrin repeat domain-containing protein SOWAHA
MAPK regulated corepressor interacting protein 2
Solute carrier organic anion transporter family member 1A4
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1
Knockin mice show impaired spermatogenesis, loss of histone H3K4me3 binding, severe disruption of chromosomal synapsis and DNA double-strand breaks repair in spermatocytes; when associated with I-247 and P-294.
Knockin mice show impaired spermatogenesis, loss of histone H3K4me3 binding, severe disruption of chromosomal synapsis and DNA double-strand breaks repair in spermatocytes; when associated with I-247 and R-292.
Knockin mice show impaired spermatogenesis, loss of histone H3K4me3 binding, severe disruption of chromosomal synapsis and DNA double-strand breaks repair in spermatocytes; when associated with R-292 and P-294.
Zinc finger CW-type PWWP domain protein 1
Decreased activity; when associated with A-422 and A-429.
Decreased activity; when associated with A-422 and A-436.
Decreased activity; when associated with A-429 and A-436.
Phosphoserine; by autocatalysis and DAPK1
Cytochrome c oxidase assembly protein COX11, mitochondrial
Postacrosomal sheath WW domain-binding protein
Abolished phosphorylation by MAPK1/MAPK3.
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Putative uncharacterized protein C19orf81 homolog
Elongation of very long chain fatty acids protein 2
28 kDa heat- and acid-stable phosphoprotein
Casein kinase substrate phosphoprotein PP28
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Mitogen-activated protein kinase kinase kinase kinase 5
CDK5 regulatory subunit-associated protein 2
Required for centrosomal attachment, Golgi localization and CALM1 interaction
Required for centrosomal attachment, Golgi targeting and CALM1 interaction
Glucosamine 6-phosphate N-acetyltransferase
Important for selectivity toward medium-length fatty acids
Abolishes binding to RAR, RXR and RAR/RXR.
Ligand-dependent nuclear receptor binding
Reduces binding to RAR, RXR and RAR/RXR.
Required for targeting to small nuclear foci
Fibronectin type III domain-containing protein 9
Meiosis-specific nuclear structural protein 1
Tetratricopeptide repeat protein 23-like
Cysteinyl-selenocysteine (Cys-Sec); redox-active
Acyl-CoA dehydrogenase/oxidase C-terminal
Protein phosphatase 1 regulatory subunit 7
Abolishes amino-acid binding without affecting interaction with the translating ribosome.
Abolishes pyruvate kinase activity without affecting interaction with the ribosome.
Tubulin--tyrosine ligase-like protein 12
Found in strains resistant to unrelated intracellular parasites, such as Mycobacterium bovis, Salmonella typhimurium and Leishmania donovani; highly glycosylated; locates properly to macrophage late endosome/lysosome membranes; has divalent transition metal transporter activity.
Natural resistance-associated macrophage protein 1
CUB and sushi domain-containing protein 1
Mediates preference for acidic residues at subsite P1'
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Tyrosine-protein phosphatase non-receptor type 13
Cytochrome c oxidase assembly protein COX15 homolog
Calcium homeostasis endoplasmic reticulum protein
Translin-associated factor X-interacting protein 1 N-terminal
PKA-RI and PKA-RII subunit binding domain
Loss of catalytic activity. No effect on BCL2L11-binding, BCL2L11 stabilization, nor on apoptosis.
Ubiquitin carboxyl-terminal hydrolase 27
Partially rescue the unresponsiveness of osteoblasts and fibroblasts lacking Slc39a13 against BMP4 and TGFB1.
Does not affect ability to promote H3K27me3 methylation; when associated with S-75.
Does not affect ability to promote H3K27me3 methylation; when associated with S-78.
Impairs ability to promote H3K27me3 methylation without affecting ability to associate with the PRC2 complex; when associated with A-48.
Impairs ability to promote H3K27me3 methylation without affecting ability to associate with the PRC2 complex; when associated with A-54.
Impairs ability to promote H3K27me3 methylation without affecting ability to associate with the PRC2 complex; when associated with A-72.
Impairs ability to promote H3K27me3 methylation without affecting ability to associate with the PRC2 complex; when associated with A-74.
Probable ATP-dependent RNA helicase DDX10
Mitochondrial import inner membrane translocase subunit Tim10
Tyrosine-protein phosphatase non-receptor type 7
Formyl peptide receptor-related sequence 4
DNA-directed RNA polymerase III subunit RPC10
Kelch repeat and BTB domain-containing protein 2
Impairs DNA-binding and phosphorylation by MAPK1.
Required for DNA-binding and interaction with NFKBIA
Small nuclear ribonucleoprotein-associated protein N
Nuclear envelope pore membrane protein POM 121
Low-density lipoprotein receptor-related protein 11
Serine/threonine-protein kinase 4 18kDa subunit
Serine/threonine-protein kinase 4 37kDa subunit
Gypsy retrotransposon integrase-like protein 1
Retinoblastoma-associated protein C-terminal
Retinoblastoma-associated protein N-terminal
Abolishes nuclear pore localization; when associated with 272-GSGSGSGSG-280.
Abolishes nuclear pore localization; when associated with S-284.
Important for nuclear localization and chromatin binding
Potassium voltage-gated channel subfamily D member 1
Methenyltetrahydrofolate synthase domain-containing protein
Methionine adenosyltransferase 2 subunit beta
Fanconi anemia core complex-associated protein 24
Required for meiotic nuclear division protein 1 homolog
Alpha/beta-tubulin-N-acetyltransferase 9
CUB and zona pellucida-like domain-containing protein 1
Reduced autocatalytic cleavage. Strongly reduced autocatalytic cleavage; when associated with A-196. Strongly reduced autocatalytic cleavage; when associated with A-196 and 190-A-A-191.
Strongly reduced autocatalytic cleavage; when associated with A-196 and A-199. Slightly reduced autocatalytic cleavage; when associated with A-196.
Strongly reduced autocatalytic cleavage; when associated with A-199. Strongly reduced autocatalytic cleavage; when associated with A-199 and 190-A-A-191. Slightly reduced autocatalytic cleavage; when associated with 190-A-A-191.
Transmembrane protease serine 11C catalytic chain
Transmembrane protease serine 11C non-catalytic chain
Soluble calcium-activated nucleotidase 1
Could be involved in the assembly of the multisynthetase complex
Leucine-rich repeat-containing protein 61
Abolished ADP-ribosyltransferase activity in vitro without affecting the NAD-dependent protein deacetylase activity.
Abolishes in vitro phosphorylation by CaMK2; when associated with A-154; A-649 and A-651.
Abolishes in vitro phosphorylation by CaMK2; when associated with A-154; A-649 and A-683.
Abolishes in vitro phosphorylation by CaMK2; when associated with A-154; A-651 and A-683.
Abolishes in vitro phosphorylation by CaMK2; when associated with A-649; A-651 and A-683.
Abolishes nuclear export; when associated with A-138; A-139; A-140; A-144 and A-145.
Abolishes nuclear export; when associated with A-425; A-427; A-428; A-429; A-430 and A-431.
Abolishes nuclear localization; when associated with A-227; A-228; A-229 and A-230.
Abolishes nuclear localization; when associated with A-37 and A-38.
Decreased acetylation, leading to increased protein deacetylase activity.
Does not affect protein deacetylase activity.
Impairs S-nitrosylation. Abolishes S-nitrosylation; when associated with S-387.
Impairs S-nitrosylation. Abolishes S-nitrosylation; when associated with S-390.
Increased deacetylase activity toward p53/TP53 and increases resistance to genotoxic stress (mimicks residue phosphorylation).
Loss of deacetylation activity. Loss of inhibition of E2F1 and loss of coactivation of FOXO1-mediated transcription.
NAD-dependent protein deacetylase sirtuin-1
Phosphothreonine; by DYRK1A, DYRK3 and MAPK8
Reduces phosphorylation. Impairs deacetylase activity toward p53/TP53 and decreases resistance to genotoxic stress. Does not change nuclear localization.
Required for interaction with the sumoylated form of CCAR2
Functional determinant of NMDA receptors
Important for association with membranes
Detected in mice with the buff mutation; leads to melanocytes with a reduced number of undermelanized melanosomes.
Vacuolar protein sorting-associated protein 33A
Complement C1q tumor necrosis factor-related protein 4
Natural cytotoxicity triggering receptor 1
MAP/microtubule affinity-regulating kinase 3
No impact on substrate affinity of SLC6A19-mediated amino acid transport.
Reduces substrate affinity of SLC6A19-mediated amino acid transport.
Higher IL17A, IL1B, IL6, CXCL1 and TREM1 expression in bone marrow-derived macrophages from mutant mice compared to wild-type, after LPS stimulation. CD8+ T cells from mutant mice have reduced PRF1 expression when activated with IL-2 compared to cells from wild-type littermates.
Higher TNFA, IL1B and IL6 expression in bone marrow-derived and peritoneal macrophages from mutant mice compared to wild-type, after VSV infection. Decreased viral clearance in mutant mice compared to wild-type. Loss of transcriptional activity shown in IFNB1 promoter-driven luciferase assay.
Vasoactive intestinal polypeptide receptor 2
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2
Fibronectin type III and SPRY domain-containing protein 1
Protein phosphatase 1 regulatory subunit 3B
Leucine-rich glioma-inactivated protein 1
Glycoprotein endo-alpha-1,2-mannosidase-like protein
Vacuolar protein sorting-associated protein 45
Cysteine-rich perinuclear theca protein 1
Abolishes production of active form of enzyme.
snRNA-activating protein complex subunit 1
Interferon-induced helicase C domain-containing protein 1
Required for its localization in the mitotic spindle and interaction with alpha-tubulin
N-linked (GlcNAc...) asparagine; partial
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
In plt1; loss of function inducing thrombocytopenia and kidney disease.
Interferon-stimulated 20 kDa exonuclease-like 2
N(6)-adenine-specific methyltransferase METTL4
100-fold decreased affinity for L-rhamnose.
Necessary and sufficient for interaction with IDAS and CDT1
Required for drug-induced death protein 1
Zinc finger CCCH-type with G patch domain-containing protein
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2
17-beta-hydroxysteroid dehydrogenase type 6
KH homology domain-containing protein 1C
Platelet-activating factor acetylhydrolase IB subunit alpha1
Peptide chain release factor 1, mitochondrial
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
Interaction with the C-terminus of NDC80 and the SPBC24-SPBC25 subcomplex
Interaction with the N-terminus of NDC80
Hydroxysteroid dehydrogenase-like protein 2
Thymidylate synthase/dCMP hydroxymethylase
Necessary to inhibit MRTFA-induced SRF transcriptional activity
Important for selectivity against fructose
Solute carrier family 2, facilitated glucose transporter member 3
Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1
Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2
Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D
N-alpha-acetyltransferase 25, NatB auxiliary subunit
Important for integrin interaction and activation
Decreases autophosphorylation, binding to tRNA and Sindbis virus genomic RNA and eIF-2-alpha phosphorylation in amino acid-starved cells; when associated with I-1143.
Decreases autophosphorylation, binding to tRNA and Sindbis virus genomic RNA and eIF-2-alpha phosphorylation in amino acid-starved cells; when associated with L-1142.
Inhibits autophosphorylation, eIF-2-alpha phosphorylation and antiviral activity against Sindbis virus.
Lipopolysaccharide-responsive and beige-like anchor protein
Coiled-coil domain-containing protein 187
Malonate--CoA ligase ACSF3, mitochondrial
POU domain, class 4, transcription factor 2
Required for DNA-binding and transcriptional repression
Stimulates induction of neurite outgrowth and expression of synaptic genes. Abolishes the inhibitory effect on basal transcription and on gene activation by POU4F1.
Can cooperate with an activated Ras to transform fibroblasts.
N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate
Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM
Important for interaction with SUMO1 and SUMO2
Lamina-associated polypeptide 2 alpha C-terminal
Sufficient for E3 SUMO-protein ligase activity
In Jll; dominant allele that increases enzyme activity, and decreases fasting insulin levels, fasting leptin levels, weight gain and fat accumulation when mice are kept on a high fat diet.
Eukaryotic translation initiation factor 1
Centrosomal protein Cep63/Deup1 N-terminal
MORC family CW-type zinc finger protein 4
Disrupts LDB1-binding; when associated with G-28.
Disrupts LDB1-binding; when associated with G-88.
Coiled-coil domain-containing protein 43
Interaction with RAD52, TIPIN, UNG and XPA
Abolishes homodimerization. Strongly decreases affinity for pyridoxal phosphate.
Cytochrome c oxidase subunit 7C, mitochondrial
In A1, B(A) and B(C); requires 2 nucleotide substitutions.
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
Solute carrier organic anion transporter family member 3A1
Abolishes interaction with AP-2 complex.
Abolishes lipid kinase activity. Does not affect targeting of TLN1 to plasma membrane. Affects assembly of TLN1 into focal adhesions. Affects uropodium formation and retraction of the cell rear.
Cannot rescue the effect PIP5K1C knockdown on EGF-stimulated cell migration. Decreased tailin assembly into focal adhesions.
Cannot rescue the effect PIP5K1C knockdown on EGF-stimulated cell migration. Does not affect lipid kinase activity. Does not alter binding to tailin. Decreased tailin assembly into focal adhesions. Increased interaction with PLCG1.
Loss of phosphorylation by CSK. Abolishes interaction with AP-2 complex. Cannot rescue the effect PIP5K1C knockdown on EGF-stimulated cell migration.
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Phosphoribosyl pyrophosphate synthase-associated protein 2
Multiple myeloma tumor-associated protein 2 homolog
Xin actin-binding repeat-containing protein 2
Spermatogenesis-associated serine-rich protein 2
Lysosomal protective protein 20 kDa chain
Lysosomal protective protein 32 kDa chain
In isoform 2, isoform 3, isoform 4 and isoform 6.
In isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6.
Soluble interleukin-15 receptor subunit alpha
In isoform Alpha-1 and isoform Alpha-deltaE6.
Protein interaction domain; mediates interaction with DNA polymerase zeta
Membrane-associated progesterone receptor component 2
Interchain (between light and heavy chains)
Interaction with PxVP motif in substrates of the catalytic subunit
Cytokine-inducible SH2-containing protein
Strongly reduces the interaction with MLPH.
Sodium-dependent phosphate transporter 2
Leucine-rich repeat-containing protein 3B
Probable ATP-dependent RNA helicase DDX46
POU domain, class 2, transcription factor 2
Epidermal growth factor receptor substrate 15-like 1
Leucine zipper putative tumor suppressor 3
Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7
SH3 and cysteine-rich domain-containing protein
Sperm-associated microtubule inner protein 4
Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding
Required for TBK1 and IKBKE-dependent IFNB1 activation
Uncharacterized protein C16orf74 homolog
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
Loss of Rho GAP activity. Enhances cell spreading.
Strongly reduces phosphorylation by CSK; when associated with F-1399.
Strongly reduces phosphorylation by CSK; when associated with F-1404.
cGMP-dependent protein kinase interacting
Mediator of RNA polymerase II transcription subunit 17
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Disintegrin and metalloproteinase domain-containing protein 21
Induces aberrant nuclear localization of the phosphorylated form.
No change in binding to DNA and confers DNA-binding sensitivity to sulfhydryl modifications.
Nuclear factor of activated T-cells, cytoplasmic 2
Required for cytoplasmic retention of the phosphorylated form
Heterogeneous nuclear ribonucleoprotein U-like protein 1
Necessary for interaction with BRD7 and transcriptional activation
Uncharacterized protein C21orf62 homolog
Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cations
Fails to bind to NIH-3T3 fibroblast cells; when associated with 273-A--A-276.
Fails to bind to NIH-3T3 fibroblast cells; when associated with A-291.
Fails to bind to heparan sulfate or to NIH-3T3 fibroblast cells; when associated with A-238 and A-244.
Fails to bind to heparan sulfate or to NIH-3T3 fibroblast cells; when associated with A-238 and A-295.
Fails to bind to heparan sulfate or to NIH-3T3 fibroblast cells; when associated with A-244 and A-295.
No effect on binding to NIH-3T3 fibroblast cells.
No effect on binding to NIH-3T3 fibroblast cells; when associated with A-109.
No effect on binding to NIH-3T3 fibroblast cells; when associated with A-216.
3-hydroxyisobutyrate dehydrogenase, mitochondrial
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
Beta-hexosaminidase eukaryotic type N-terminal
Abolishes ubiquitin binding and localization to nuclear foci after UV-induced DNA damage.
Impairs ubiquitin binding and post-translation modification via ubiquitination; when associated with A-508. Abolishes ubiquitin binding and localization to nuclear foci after UV-induced DNA damage but does not affect catalytic activity; when associated with A-509, A-693 and A-694.
Impairs ubiquitin binding and post-translation modification via ubiquitination; when associated with A-509. Abolishes ubiquitin binding and localization to nuclear foci after UV-induced DNA damage but does not affect catalytic activity; when associated with A-508, A-693 and A-694.
Impairs ubiquitin binding and post-translation modification via ubiquitination; when associated with A-693. Abolishes ubiquitin binding and localization to nuclear foci after UV-induced DNA damage but does not affect catalytic activity; when associated with A-508, A-509 and A-693.
Impairs ubiquitin binding and post-translation modification via ubiquitination; when associated with A-694. Abolishes ubiquitin binding and localization to nuclear foci after UV-induced DNA damage but does not affect catalytic activity; when associated with A-508, A-509 and A-694.
Coiled-coil domain-containing protein 77
Neuroblastoma-amplified sequence N-terminal
Cytochrome b-c1 complex subunit 2, mitochondrial
Reduced tyrosine phosphorylation. Abolished ability to mediate recruitment of PTPN11/SHP-2.
Reduced tyrosine phosphorylation. Decreased ability to mediate recruitment of PTPN11/SHP-2.
Cell growth regulator with RING finger domain protein 1
Loss of phosphorylation. Unable to suppress apoptosis.
KAT8 regulatory NSL complex subunit 1-like protein
Cilia-and flagella-associated protein 96
Abolishes deacylase and deacetylase activities. Reduced interaction with SIRT1, without abolishing it.
NAD-dependent protein deacetylase sirtuin-7
Impaired enzyme activity and polyuridylated RNA-binding.
Loss of enzyme activity and polyuridylated RNA-binding; when associated with A-612.
Loss of enzyme activity and polyuridylated RNA-binding; when associated with A-74.
Ankyrin repeat domain-containing protein 61
Loss of function and transforming activity.
PT region; mediates the BCR-dependent translocation to plasma membrane
Ras exchanger motif region; required for transforming activity
Suppress the PT region-mediated translocation to plasma membrane
No chondroitin sulfate attachment. no effect on transport to the cell surface.
No effect on chondroitin sulfate attachment.
Monoacylglycerol/Diacylglycerol O-acyltransferase
Abolishes export from nucleus; when associated with A-67 and A-87.
Abolishes export from nucleus; when associated with A-67 and A-92.
Abolishes export from nucleus; when associated with A-87 and A-92.
Abolishes ligand-induced translocation to the nucleus.
Abolishes ligand-induced translocation to the nucleus; when associated with A-22 and A-31.
Abolishes ligand-induced translocation to the nucleus; when associated with A-22 and A-32.
Abolishes ligand-induced translocation to the nucleus; when associated with A-31 and A-32.
Abolishes homodimerization; when associated with A-1024.
Abolishes homodimerization; when associated with A-1030.
Required for interaction with TGFBR1 and promotion of TGF-beta signaling
Loss of kinase activity; when associated with T-209.
Loss of kinase activity; when associated with T-214.
MAP kinase-interacting serine/threonine-protein kinase 1
N-acetylthreonine; in WD repeat-containing protein 61, N-terminally processed
Superkiller complex protein 8, N-terminally processed
Translation initiation factor beta propellor-like
Probable inactive ribonuclease-like protein 13
Ciliary-associated calcium-binding coiled-coil protein 1
NADPH-dependent diflavin oxidoreductase 1
Critical for hydrolysis GM2 gangliosides
Abolishes catalytic activity on phthalazine and acetaldehyde. Decreases catalytic efficiency on benzaldehyde and retinal. Abolishes catalytic activity; when associated with E-806.
Decreases substrate affinity and activity on benzaldehyde, phthalazine and acetaldehyde, while increases affinity for more hydrophobic aldehydes like retinal. Abolishes catalytic activity; when associated with R-884.
In strain: C57BL/6 XCBA, requires 2 nucleotide substitutions.
L-serine dehydratase/L-threonine deaminase
Tryptophan synthase beta chain-like PALP
FGGY carbohydrate kinase domain-containing protein
Peptidyl-prolyl cis-trans isomerase FKBP9
Sterile alpha motif domain-containing protein 15
Involved in pH-sensing to the transport activity regulation
Sodium-coupled neutral amino acid transporter 5
Tumor necrosis factor alpha-induced protein 2
CBP80/20-dependent translation initiation factor
Abolishes ability to rescue Purkinje cell degeneration in pcd mice when expressed in a transgene.
Abolishes deglutamylase activity; when associated with Q-915.
Abolishes deglutamylase activity; when associated with S-912.
Solute carrier family 52, riboflavin transporter, member 3
Abolished both phosphorylation and pyrophosphorylation.
Cytoplasmic dynein 1 intermediate chain 2
Low-density lipoprotein receptor class A domain-containing protein 3
Interferon-induced transmembrane protein 1
Mice bearing this mutation exhibit several retinal pigment epithelium (RPE) anomalies, including pigmentary abnormalities, focal thickening, elevated lesions, and decreased light-activated responses. Mutant animals show dysmorphology in the form of RPE cell shedding and accumulation of large multinucleated RPE cells.
No effect on cell aggregation or E-cadherin/catenin complex assembly. Decreases strength of cell-cell adhesion.
No effect on cell aggregation or E-cadherin/catenin complex assembly. Increases strength of cell-cell adhesion.
B-cell scaffold protein with ankyrin repeats
Necessary for interaction with NR6A1 C-terminus
Necessary for interaction with NR6A1 N-terminus
Necessary for transcriptional repression
Polypeptide N-acetylgalactosaminyltransferase 18
Transmembrane and ubiquitin-like domain-containing protein 2
N-acetylthreonine; in 40S ribosomal protein S5, N-terminally processed
Small ribosomal subunit protein uS7, N-terminally processed
FAST kinase domain-containing protein 2, mitochondrial
T-cell surface glycoprotein CD3 gamma chain
Abolishes phosphatase activity and abolishes coactivation of the SIX1-DACH1 complex.
Diminishes phosphatase activity by 24-fold.
Required for targeting to the endoplasmic reticulum
Phosphoinositide 3-kinase regulatory subunit 6
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
U6 snRNA-associated Sm-like protein LSm7
Dipeptidyl aminopeptidase-like protein 6
Peptidase S9 prolyl oligopeptidase catalytic
V-type proton ATPase subunit S1/VOA1 transmembrane
Inactive serine/threonine-protein kinase VRK3
Interleukin-1 receptor-associated kinase 4
Tumor protein p53-inducible nuclear protein 2
Nuclear pore membrane glycoprotein 210-like
EEF1AKMT4-ECE2 readthrough transcript protein
Disintegrin and metalloproteinase domain-containing protein 5
Activation by thioester intermediate formation with UBA6
Impaired conjugation of target proteins.
Leucine-rich repeat-containing protein 47
Actin, aortic smooth muscle, intermediate form
N-acetylglutamate; in Actin, aortic smooth muscle
Solute carrier family 2, facilitated glucose transporter member 9
Stress-associated endoplasmic reticulum protein 1
Eukaryotic translation initiation factor 2 subunit 3, Y-linked
Cytochrome c1, heme protein, mitochondrial
Lipid droplet-regulating VLDL assembly factor AUP1
Abolishes RNA-binding activity but not AR-mediated transcription coactivation; when associated with A-118; A-120 and A-197.
Abolishes RNA-binding activity but not AR-mediated transcription coactivation; when associated with A-118; A-120 and A-199.
Abolishes RNA-binding activity but not AR-mediated transcription coactivation; when associated with A-118; A-197 and A-199.
Abolishes RNA-binding activity but not AR-mediated transcription coactivation; when associated with A-120; A-197 and A-199.
Sufficient for paraspeckles localization
Sufficient for perinucleolar caps localization and interaction with NONO
Protein phosphatase 1 regulatory subunit 15B
Zinc finger and BTB domain-containing protein 41
Abolished oligomerization without affecting interaction with KEAP1; when associated with A-69.
Abolished oligomerization without affecting interaction with KEAP1; when associated with A-7.
Does not affect interaction with KEAP1. Decreased phosphorylation by MTOR.
Greatly decreases interaction with MAP1LC3B.
Phosphomimetic mutant; promotes interaction with KEAP1 and nuclear accumulation of NFE2L2/NRF2.
Strongly decreased interaction with KEAP1.
Serine-rich coiled-coil domain-containing protein 2
Leucine-rich repeat-containing protein 34
In explorer; no obvious external deformities but mutants are 40% smaller than wild-type litter mates and show reduced frequency of CD3+ T cells, CD4+ T cells and CD8+ T cells which all display elevated CD44 expression.
Intraflagellar transport protein 43 homolog
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Glucose-dependent insulinotropic receptor
DNA-directed RNA polymerases I, II, and III subunit RPABC1
RNA polymerase subunit H/Rpb5 C-terminal
Essential for autoinhibition maintenance
Essential for autoinhibition maintenance by promoting interaction of the N and C termini
Involved in AKAP5 and PRKAR2A interaction
Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction
Required for both calcium stimulation and maintenance of autoinhibition
Eliminates potentiation of glycine-mediated currents by Zn(2+) and causes neuromotor defects similar to human startle disease.
Important for obstruction of the ion pore in the closed conformation
Reduces the increase of channel activity in response to ethanol and improves tolerance of intoxicating levels of alcohol.
Lysosomal targeting motif. Required for AP1G1, AP2A2 and AP3D1 interaction
Does not inhibit lysosomal/late endosomal targeting.
Inhibits lysosomal/late endosomal targeting.
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Rap guanine nucleotide exchange factor 3
Phosphomimetic mutant that lead to increased centrosome number.
Weak effect possibly due to low expression of this mutant.
Cleavage; by factor Xa, factor XIIa, factor IXa, or thrombin
Rho guanine nucleotide exchange factor 10-like protein
Choline/ethanolaminephosphotransferase 1
Transmembrane and coiled-coil domains protein 2
8 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-P
IQ motif and SEC7 domain-containing protein 2
N-terminal EF-hand calcium-binding protein 2
Cyclic nucleotide-binding domain-containing protein 2
DET1- and DDB1-associated protein 1 N-terminal
SAM pointed domain-containing Ets transcription factor
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form
Interaction with 5' end of substrate DNA
Mitogen-activated protein kinase kinase kinase 8
Decreased ability to bind heterodimeric capping protein (CP) and to inhibit the actin-capping activity of CP.
Loss of ability to bind heterodimeric capping protein (CP) and to inhibit the actin-capping activity of CP.
Necessary for localization at the cell membrane
Thrombospondin type-1 domain-containing protein 7A
Thrombospondin type-1 domain-containing protein 7A, soluble form
Pyridoxal phosphate phosphatase PHOSPHO2
Loss of phosphorylation. Loss of nuclear localization.
Pentatricopeptide repeat-containing protein 2, mitochondrial
Pleckstrin homology domain-containing family H member 2
U6 snRNA-associated Sm-like protein LSm8
Probable ATP-dependent RNA helicase DDX56
Peroxisome proliferator-activated receptor delta
Required for interaction with KPNB1 and EEA1
C5a anaphylatoxin chemotactic receptor 2
Vimentin-type intermediate filament-associated coiled-coil protein
Linker for activation of T-cells family member 1
Voltage-dependent L-type calcium channel subunit beta-1
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Required for correct folding and localization
Transcription elongation factor A N-terminal and central domain-containing protein 2
Decreases expression; No reduction of cAMP upon induction.
Isocitrate dehydrogenase [NADP], mitochondrial
FAST kinase domain-containing protein 5, mitochondrial
Coiled-coil domain-containing protein 91
Putative RNA polymerase II subunit B1 CTD phosphatase Rpap2
No effect on palmitoylation. No change in subcellular location; when associated with C-129.
No effect on palmitoylation. No change in subcellular location; when associated with G-118 and F-121.
No effect on palmitoylation. No change in subcellular location; when associated with H-135.
No effect on palmitoylation. No change in subcellular location; when associated with V-113 and F-121.
No effect on palmitoylation. No change in subcellular location; when associated with V-113 and G-118.
Reduced interaction with SYT9, but no effect on the interaction with HSC70.
Histone-lysine N-methyltransferase KMT5B
Loss of methyltransferase activity for H4K20me1 peptide.
Protein phosphatase 1 regulatory subunit 16A
Mediator complex subunit Med25 synapsin 1
Mediator of RNA polymerase II transcription subunit 25
Mediator of RNA polymerase II transcription subunit 25 von Willebrand factor type A
ATP-binding cassette sub-family A member 9
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
(Microbial infection) N-beta-linked (GlcNAc) arginine
Tumor necrosis factor receptor superfamily member 1A
Abolishes ubiquitination and degradation by the SCF(BTRC) complex.
Cholesterol recognition/amino acid consensus (CRAC) region
Endoplasmic reticulum membrane sensor NFE2L1
Homeobox and leucine zipper protein Homez
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Potassium voltage-gated channel subfamily KQT member 4
Important for interaction with ATG13 and for autophagosome formation
Microtubule-associated proteins 1A/1B light chain 3A
Phosphatidylethanolamine amidated glycine; alternate
Phosphatidylserine amidated glycine; alternate
Necessary and sufficient for CEP20-binding
Regulation of nuclear pre-mRNA domain-containing protein 1B
Calcium/calmodulin-dependent protein kinase II inhibitor 2
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
No effect on enzyme activity against dopamine.
Reduces enzyme activity against dopamine.
Myeloid-associated differentiation marker
EF-hand calcium-binding domain-containing protein 6
Absence of proteolytic activity. Loss of its processing into the mature form.
Cation-transporting P-type ATPase N-terminal
In dfw; results in impaired long-term Ca2+ export at stereocilia.
Plasma membrane calcium-transporting ATPase 2
Tubulin-specific chaperone cofactor E-like protein
Necessary for cell membrane association (isoform 2)
Abrogates Malassezia recognition; when associated with D-171.
Abrogates Malassezia recognition; when associated with Q-169.
Confers specificity for glucose/mannose-type carbohydrates
FXYD domain-containing ion transport regulator 6
Mice develop an age- and gene dosage-dependent hypertrophic cardiomyopathy and heart failure phenotype, characterized by almost complete loss of contractile reserve under catecholamine induced stress. They display increased in septum wall thickness, fractional shortening, and wall thickness per diameter (h/r). There is also evidence for skeletal muscle pathology. In addition, homozygous mutants show increased left ventricle (LC) mass per body weight (BW) and significantly reduced body weight. An increased nuclear localization of Csrp3 is also observed. Decreases interaction with TCAP.
Ankyrin repeat and BTB/POZ domain-containing protein 1
Selection and upkeep of intraepithelial T-cells protein 3
General transcription factor 3C polypeptide 5
Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel
COX assembly mitochondrial protein homolog
Actin-related protein 2/3 complex subunit 5-like protein
Increased mobility in differentiating cells. Greatly reduced DNA binding.
Reduced acetylation by 30%. Some loss of DNA binding and transactivation activity.
PWWP domain-containing DNA repair factor 3B
Tumor protein p63-regulated gene 1 protein
N-terminal domain; mediates the alkylhydroperoxide reductase activity
Unable to inhibit TORC1 signaling; when associated with A-419 and A-422.
Unable to inhibit TORC1 signaling; when associated with A-419 and A-426.
Unable to inhibit TORC1 signaling; when associated with A-422 and A-426.
Zinc finger and BTB domain-containing protein 46
Coiled-coil domain-containing protein 125
S100/CaBP-9k-type calcium binding subdomain
Significant reduction in interaction with EIF4E.
Mas-related G-protein coupled receptor member A1
Decreases surface expression in transfected pro-B cells and impairs interaction with FCER1G.
Important for maintaining surface expression and for interaction with FCER1G
Increases surface expression in transfected pro-B cells and impairs interaction with FCER1G.
May play an important role in murine norovirus (MNV) binding
Does not inhibit interaction with ITPR1.
Inhibits SLC4A4 dephosphorylation by PP1 phosphatase and activity.
S-adenosylhomocysteine hydrolase-like protein 1
Piezo non-specific cation channel R-Ras-binding
Piezo-type mechanosensitive ion channel component 2
Neuroblastoma suppressor of tumorigenicity 1
Stress-associated endoplasmic reticulum protein 2
Does not affect ceramide synthase activity.
In toppler (to) mice; impairs ceramide synthase activity.
Putative E3 ubiquitin-protein ligase UBR7
Sufficient to mediate interaction with PAXBP1
Cell division cycle-associated protein 2
Immunoglobulin-like domain-containing receptor 1
Complement C1q tumor necrosis factor-related protein 3
Impaired phosphorylation by MTOR, leading to constitutive nuclear localization.
MiT/TFE transcription factors N-terminal
Golgi-associated RAB2 interactor protein 1B
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Dolichol-phosphate mannosyltransferase subunit 3
KN motif and ankyrin repeat domain-containing protein 2
Dendritic cell-specific transmembrane protein
Dendritic cell-specific transmembrane protein-like
Important for enzyme activity, localization to cytoplasmic vesicles, and protein stability
Interchain (between small and large subunit)
Non-POU domain-containing octamer-binding protein
Submaxillary gland androgen-regulated protein 2, isoform delta
Submaxillary gland androgen-regulated protein 2, isoform gamma
Signal recognition particle receptor subunit alpha
Eukaryotic translation initiation factor 4 gamma 3
Necessary but not sufficient for MKNK1-binding
No effect on anion channel activity. Impairs channel selectivity, so that the channel is also permeable to Na(+) ions.
Volume-regulated anion channel subunit LRRC8A
Arginine-glutamic acid dipeptide repeats protein
Mothers against decapentaplegic homolog 6
Abnormal spindle-like microcephaly-associated protein homolog
Disrupts interaction with KATNA1:KATNB1.
Disrupts interaction with KATNA1:KATNB1; when associated with A-302.
Disrupts interaction with KATNA1:KATNB1; when associated with A-377.
Sufficient for interaction with KATNA1:KATNB1
Does not affect formation of a heterodimer with TCF3 and ability to bind DNA.
Impaired formation of a heterodimer with TCF3 and decreased ability to bind DNA.
Doublesex- and mab-3-related transcription factor C1
Doublesex- and mab-3-related transcription factor C1/C2 C-terminal
Low density lipoprotein receptor adapter protein 1
Abolishes AMPK-mediated phosphorylation.
Does not affect AMPK-mediated phosphorylation.
In isoform SREBP-1A-W42 and isoform SREBP-1C-W42.
In isoform SREBP-1C and isoform SREBP-1C-W42.
Processed sterol regulatory element-binding protein 1
Sterol regulatory element-binding protein 1
Strongly impairs affects phosphorylation by SIK1.
Chloride intracellular channel protein 6
Helical; Note=After insertion into the membrane
Ankyrin repeat and death domain-containing protein 1B
Intraflagellar transport protein 88 homolog
Transmembrane emp24 domain-containing protein 9
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Biorientation of chromosomes in cell division protein 1
T-cell receptor-associated transmembrane adapter 1
EBM motif; may mediate interaction with the EJC
Ankyrin repeat domain-containing protein 34C
Latent-transforming growth factor beta-binding protein 3
Loss of autocatalytic cleavage; when associated with A-212; A-218 and A-225.
Loss of autocatalytic cleavage; when associated with A-212; A-218 and A-387.
Loss of autocatalytic cleavage; when associated with A-212; A-225 and A-387.
Loss of autocatalytic cleavage; when associated with A-218; A-225 and A-387.
Loss of kinase ativity. Knockin mice show embryonic lethality caused by endothelial cell necroptosis leading to cardiovascular defects. Mlkl deficiency rescues the cardiovascular phenotype of knockin mice, but causes perinatal lethality caused by induction of pyroptosis.
8 X 6 AA tandem repeats of P-S-[VSG]-S-[VIAG]-[HDRL]
Present at mitochondrial membrane. Impairs interaction with HMOX1. Abolishes the response to heme.
D-2-hydroxyglutarate dehydrogenase, mitochondrial
Loss of enzyme activity. Abolishes ubiquitination in response to VEGFA binding.
Strongly reduces internalization and down-regulation of the activated receptor; when associated with A-1188.
Strongly reduces internalization and down-regulation of the activated receptor; when associated with A-1191.
Vascular endothelial growth factor receptor 2
Phosphotyrosine; by SRC and autocatalysis
Rho guanine nucleotide exchange factor 17
Volume-regulated anion channel subunit LRRC8E
Involved in binding clathrin heavy chain
ATP-binding site mutant; unable to activate MAPKAPK5.
Kinase defective mutant, abolishes activity.
Unable to activate MAPKAPK5 promote MAPKAPK5 localization to the cytoplasm.
Zinc finger FYVE domain-containing protein 16
Regulates protein turnover upon amino acid deprivation
Sodium-coupled neutral amino acid symporter 2
Transmembrane and coiled-coil domain-containing protein 4
Important for activation of transcription
Transcription initiation factor IIA gamma subunit C-terminal
Transcription initiation factor IIA gamma subunit N-terminal
Transcription initiation factor IIA subunit 2
Nuclear localization signal; in isoform 6
Prevents isoform 6 from localizing to the nucleus; when associated with A-1385.
Prevents isoform 6 from localizing to the nucleus; when associated with A-1386.
Asymmetric dimethylarginine; by PRMT1; alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate
Omega-N-methylarginine; by PRMT1; alternate
Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate
N6-(pyridoxal phosphate)lysine; alternate
Serine hydroxymethyltransferase, mitochondrial
Necessary for interaction with RAB11A and function in neurite outgrowth
Sufficient for localization to endoplasmic reticulum tubular network and for interactions with REEP1, REEP5, ATL1, ATL2, ATL3 and SPAST
Diacylglycerol O-acyltransferase 2-like protein 6
Rab proteins geranylgeranyltransferase component A 2
CREB-regulated transcription coactivator 1
No effect on interaction with 14-3-3 proteins.
Required for ubiquitination and degradation
Up-regulates CREB transcription factor activity.
Up-regulates CREB transcription factor activity. Reduces interaction with 14-3-3 proteins.
Mitochondrial potassium channel ATP-binding subunit
4-aminobutyrate aminotransferase, mitochondrial
Constitutive active mutant. In a knockin model, mouse display increased amounts of head dips and open arm time on the maze, compared to littermate controls. In addition, they also explore further into the open arm on the elevated plus maze and are less active in the closed arm compared to littermate controls. Male knockin mice display no differences in anxiety, but their locomotor activity increases compared to non-transgenic littermates.
Impairs protein kinase activity and shuttling to the cytoplasm.
Mimicks phosphorylation state, leading to localization to the cytoplasm.
No p38-alpha/MAPK14-, p38-beta/MAPK11-, ERK3/MAPK6-, ERK4/MAPK4-induced activation.
Phosphothreonine; by MAPK11, MAPK14, MAPK4, MAPK6 and PKA
Tyrosine-protein phosphatase non-receptor type 11
Ras-related C3 botulinum toxin substrate 3
Abolishes interaction with HSP70 and TNFRSF1A.
BAG family molecular chaperone regulator 4
Essential for protaglandin-E synthase activity
Interaction with ATM, CKIP, IFP35 and NMI
Pleckstrin homology domain-containing family O member 1
Homozygotes are born at Mendelian ratios and have no phenotypic abnormalities from birth to adulthood. Increased ERN1 activity.
Lowers pKa of C-terminal Cys of first active site
Lowers pKa of C-terminal Cys of second active site
Abolishes phosphoinositide-binding and ability to activate TRPV1 without affecting the interaction with TRPV1.
Abolishes phosphoinositide-binding but does not affect the interaction with TRPV1.
V-type proton ATPase subunit B, kidney isoform
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
Activity-dependent neuroprotector homeobox protein
Neuroprotective peptide; contributes to CTNNB1-binding, but less effective than whole N-terminal region
N-acetylated-alpha-linked acidic dipeptidase 2
Abolished serotonylation by TGM2. Reduced neurite length.
Spermatid perinuclear RNA-binding protein
SURP and G-patch domain-containing protein 1
Tetratricopeptide repeat protein 19, mitochondrial
Abolishes phosphorylation and prevents activation of caspase-1 and pyroptosis in response to S.typhimurium.
Mimics phosphorylation; causes rapid macrophage pyroptosis without infection.
NLR family CARD domain-containing protein 4
Increases surface expression in transfected pro-B cells and enhances interaction with FCER1G. Slightly increases surface expression and enhances interaction with FCER1G; when associated with 189-Y--L-198.
Reduces surface expression in transfected pro-B cells and enhances interaction with FCER1G. Slightly increases surface expression in transfected pro-B cells and enhances interaction with FCER1G; when associated with 177-S--R-182.
Coiled-coil domain-containing protein 9B
Constitutively active. Disrupts general recycling of receptors in embryonic fibroblasts.
3 X 7 AA tandem repeats of [PT]-[AT]-A-[ENT]-[PT]-[PTS]-[AG]
Uncharacterized protein C11orf96 homolog
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Protein mono-ADP-ribosyltransferase PARP6
CPX chromosomal region candidate gene 1 protein homolog
Rho guanine nucleotide exchange factor 38
Introduces an N-glycosylation site and disrupts interaction with NGF and BDNF.
Loss of activity and phosphorylation. Unable to rescue aberrant mitochondrial fission in PINK1 null mutant neurons.
Abolishes ATG12 conjugation, leading to an expansion in mitochondrial mass and fragmented mitochondrial morphology. Does not affect PE-conjugation to ATG8-like proteins.
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)
Guanine nucleotide-binding protein-like 1
Calcium-activated potassium channel BK alpha subunit
Loss of nuclear localization. Reduces DNA binding.
Voltage-gated monoatomic cation channel TMEM109
EJC-binding motif 1; mediates interaction with the EJC
EJC-binding motif 2; mediates interaction with the EJC
Doublesex- and mab-3-related transcription factor A2
Kinase non-catalytic C-lobe domain-containing protein 1
Abolishes interaction with FBXW11. Prevents interalization from the cell membrane and lysosomal degradation.
Ubiquitin carboxyl-terminal hydrolase 12
Cytokine-dependent hematopoietic cell linker
Increases natural killer cell activation and interferon-gamma production. Loss of FGR binding.
Loss of binding to FYB1 and MAP4K1. Reduced tyrosine phosphorylation. No effect on the suppression of natural killer cell activation and suppression of interferon-gamma production.
Loss of phosphorylation and loss of interaction with PLCG1, PLCG2 and VAV. No effect on the suppression of natural killer cell activation and suppression of interferon-gamma production; when associated with F-69, F-101, F-153, F-174 and F-188.
Loss of phosphorylation and loss of interaction with PLCG1, PLCG2 and VAV. No effect on the suppression of natural killer cell activation and suppression of interferon-gamma production; when associated with F-69, F-96, F-101, F-153 and F-174.
Loss of phosphorylation and loss of interaction with PLCG1, PLCG2 and VAV. No effect on the suppression of natural killer cell activation and suppression of interferon-gamma production; when associated with F-69, F-96, F-101, F-153 and F-188.
Loss of phosphorylation and loss of interaction with PLCG1, PLCG2 and VAV. No effect on the suppression of natural killer cell activation and suppression of interferon-gamma production; when associated with F-69, F-96, F-101, F-174 and F-188.
Loss of phosphorylation and loss of interaction with PLCG1, PLCG2 and VAV. No effect on the suppression of natural killer cell activation and suppression of interferon-gamma production; when associated with F-69, F-96, F-153, F-174 and F-188.
Loss of phosphorylation and loss of interaction with PLCG1, PLCG2 and VAV. No effect on the suppression of natural killer cell activation and suppression of interferon-gamma production; when associated with F-96, F-101, F-153, F-174 and F-188.
Mediates interaction with LAT, GRB2, and FGR; involved in translocation to the glycolipid-enriched microdomain and restoration of BCR-induced calcium response in BLNK-deficient DT40 cells expressing LAT
Mediates interaction with PLCG1; essential for BCR signaling; involved in restoration of BCR-induced calcium response and ERK2 and JNK2 activation in BLNK-deficient cells expressing LAT
Slightly increases natural killer cell activation and interferon-gamma production.
Loss of dimerization. Almost complete loss of DNA-binding. Reduced transcriptional repression activity.
Ubiquitin-associated and SH3 domain-containing protein B
Docking to the peroxisome membrane and binding to PEX3
Necessary for PEX19 function on peroxisome biogenesis
G-protein coupled receptor-associated protein LMBRD2
3 X 7 AA tandem repeats of A-[GR]-T-S-T-A-Q
ATP synthase subunit gamma, mitochondrial
Putative transferase CAF17 homolog, mitochondrial
Endoplasmic reticulum resident protein 44
Glycolipid transfer protein homology domain
Pleckstrin homology domain-containing family A member 8
Low-density lipoprotein receptor-related protein
Low-density lipoprotein receptor-related protein 6
Interaction with the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex
Interaction with the N-terminus of CDCA1
Growth hormone-releasing hormone receptor
Large ribosomal subunit protein uL6 alpha-beta
Cyclin-dependent kinase 2-associated protein 2
Abrogates tetramerization, reduces dimerization, does not affect binding to microtubules and to phosphorylated light-activated rhodopsin; when associated with A-198, or with A-198 and V-349.
Abrogates tetramerization, reduces dimerization, does not affect binding to microtubules and to phosphorylated light-activated rhodopsin; when associated with A-86 and A-198.
Abrogates tetramerization, reduces dimerization, does not affect binding to microtubules and to phosphorylated light-activated rhodopsin; when associated with A-86, or with A-86 and V-349.
In strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
In strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf.
In strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
In strain: C57BL/10SnJ, HMI/Msf, MSM/Msf and SWN/Msf.
CKLF-like MARVEL transmembrane domain-containing protein 2A
Cationic amino acid transporter C-terminal
High affinity cationic amino acid transporter 1
Zinc finger CCCH domain-containing protein 8
Abolishes the formation of KLRG1/PTPN11 and KLRG1/INPP5D.
Abrogates completely INPP5D recruitment.
Killer cell lectin-like receptor subfamily G member 1
Heterochromatin protein 1-binding protein 3
Pyridoxal-dependent decarboxylase domain-containing protein 1
Mas-related G-protein coupled receptor member E
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Increases pain sensitivity; reduces threshold for induction of cortical spreading depression; increases arterial dilation during cortical spreading depression and increases spontaneous and evoked calcium signaling in astrocytes.
Sprouty-related, EVH1 domain-containing protein 3
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Mitochondrial intermembrane space import and assembly protein 40
26S proteasome non-ATPase regulatory subunit 1
WAP four-disulfide core domain protein 2
Sperm acrosome membrane-associated protein 3, membrane form
Sperm acrosome membrane-associated protein 3, processed form
Spermatogenesis associated 6-like protein
Spermatogenesis-associated protein 6 N-terminal
Transcription initiation factor TFIID subunit 12
Pituitary-specific positive transcription factor 1
DNA repair and recombination protein RAD54-like
Required for chromatin remodeling, strand pairing activities and coupling of ATPase activity
Identified in warfarin-resistant animals.
Vitamin K epoxide reductase complex subunit 1
Fertilization-influencing membrane protein
GTPase-activating Rap/Ran-GAP domain-like protein 3
Mediator of RNA polymerase II transcription subunit 4
Potassium voltage-gated channel subfamily E member 3
Serine/threonine kinase-like domain-containing protein STKLD1
ER degradation-enhancing alpha-mannosidase-like protein 2
Cardiac-enriched FHL2-interacting protein
Impairs cysteinyl leukotrienes synthesis and phagocytosis of IgG immune complexes by synovial fluid monocyte/macrophage cells.
Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum
Interaction with the K-D-E-L motif on target proteins
MAM and LDL-receptor class A domain-containing protein 1
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Important for homomultimer formation and localization to presynaptic regions
Tumor protein p63-regulated gene 1-like protein
Probable U3 small nucleolar RNA-associated protein 11
Complement C1s-A subcomponent heavy chain
Complement C1s-A subcomponent light chain
Necessary for interaction with TCEA1 and transactivation activity
Transcription elongation factor Eaf N-terminal
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
N-end rule aminoacyl transferase C-terminal
3 X 12 AA tandem repeats of G-P-G-I-G-R-P-[HP]-P-P-P-[PF]
Submaxillary gland androgen-regulated protein 3A
AF1; mediates transcriptional activation
AF2; mediates transcriptional activation
AF3; mediates transcriptional activation (in isoform B)
Mediates transcriptional transrepression (in isoform A)
Leucine-rich repeat transmembrane neuronal protein 1
Mice have normal brain size at 6 months of age and do not show cerebellar degeneration or defective neuronal arborization. Neurons from male mice also do not demonstrate an abnormality in intraendosomal pH compared with controls.
In Schlei; decreases cilium assembly; loss of protein localization to cilium.
Glutaredoxin domain-containing cysteine-rich protein 2
Dehydrodolichyl diphosphate synthase complex subunit Dhdds
C-terminal conserved inhibitory domain (CCID)
Chorion-specific transcription factor GCMb
Peptidase M1 membrane alanine aminopeptidase
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8
70% reduction of GAP activity; when associated with A-56.
70% reduction of GAP activity; when associated with V-169.
Constitutively active channel that is targeted to the cell membrane.
Dileucine internalization motif; mediates AP2 complex-dependent internalization
Dileucine motif; mediates targeting to lysosomes
Required for palmitoylation and association with membranes
Beta-adaptin appendage C-terminal subdomain
Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain
General transcription factor IIH subunit 1
Enhances basal channel activity and abolishes stimulation by calcineurin.
Loss of interaction with calcineurin and activation by elevated intracellular calcium; when associated with A-214.
Strongly reduced activation by elevated intracellular calcium. Loss of interaction with calcineurin and activation by elevated intracellular calcium; when associated with A-212.
Strongly reduced current amplitude and localization to cell membrane.
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2
Cleavage; by subtilisin-like proprotein convertase 4
Cleaved by subtilisin-like proprotein convertase 4.
Cleaved by subtilisin-like proprotein convertase.
Not cleaved by subtilisin-like proprotein convertase 4.
Not cleaved by subtilisin-like proprotein convertase 4. Not cleaved by subtilisin-like proprotein convertase; when associated with A-795.
Not cleaved by subtilisin-like proprotein convertase. Not cleaved by subtilisin-like proprotein convertase; when associated with A-1053.
WD repeat and FYVE domain-containing protein 1
Coiled-coil domain-containing protein 178
Collagen-like Alzheimer amyloid plaque component
FYVE, RhoGEF and PH domain-containing protein 1
Almost abolishes MCM complex DNA helicase activity. Strongly decreases MCM complex ATPase activity. No effect on MCM complex formation. No effect on ATP and ssDNA binding.
Strongly decreases MCM complex ATPase and DNA helicase activities. No effect on MCM complex formation. No effect on ATP and ssDNA binding.
In Rex mutant M100573; mice exhibit curly hair and vibrissae. The diameter of the hair shaft is irregular due to morphological abnormalities in all three layers of the irs.
In Rex mutant Re; mice exhibit curly hair and vibrissae. The diameter of the hair shaft is irregular due to morphological abnormalities in all three layers of the irs.
ATP-binding cassette sub-family A member 6
Activating signal cointegrator 1 complex subunit 1
Gamma-aminobutyric acid receptor subunit alpha-3
Spindle and kinetochore-associated protein 2
Mediates preference for Asp-containing substrates
Calcium uniporter protein, mitochondrial
Strongly reduces calcium channel activity; when associated with V-256.
Strongly reduces calcium channel activity; when associated with W-251.
21 X 2 AA approximate tandem repeats of P-Q
Tyrosine-protein phosphatase non-receptor type 23
Proline-rich nuclear receptor coactivator 2
Abolishes RNA-binding but not homodimerization; when associated with D-43; D-82 and D-84.
Abolishes RNA-binding but not homodimerization; when associated with D-43; D-82 and D-87.
Abolishes RNA-binding but not homodimerization; when associated with D-43; D-84 and D-87.
Abolishes RNA-binding but not homodimerization; when associated with D-82; D-84 and D-87.
Ras association domain-containing protein 9
Nuclear respiratory factor 1 NLS/DNA-binding dimerisation
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
In wobbly mutant; destabilization of the elongator complex and reduced tRNA wobble base modification leading to protein misfolding and aggregation in Purkinje neurons (PN), PN degeneration, microgliosis triggered by the NLPR3 inflammasome and an ataxia-like phenotype.
Abolishes magnesium and calcium-binding to the EF-hand 5 domain (EF5).
Microtubule-associated serine/threonine-protein kinase 4
Endothelial cell-selective adhesion molecule
T-cell-specific surface glycoprotein CD28
Serine-rich and transmembrane domain-containing protein 1
Myelin-associated oligodendrocyte basic protein
Secretory carrier-associated membrane protein 4
Basic leucine zipper transcriptional factor ATF-like
Decreased phosphorylation; when associated with A-43.
Decreased phosphorylation; when associated with A-48.
Does not affect interaction with IRF4 and ability to mediate differentiation of Th17 cells. Retains 50% of activity; when associated with D63 and 69-Q-T-70. Loss of function; when associated with Q-55; A-56 and D-63.
Impairs interaction with IRF4 and the recruitment of IRF4 to AICE motifs, leading to defects in mediate differentiation of Th17 cells. Loss of function; when associated with A-56; D-63 and K-77.
Loss of function; when associated with Q-55; D-63 and K-77.
Retains 50% of activity; when associated with 69-Q-T-70 and K-77. Loss of function; when associated with Q-55; A-56 and K-77.
Retains 50% of activity; when associated with D-63 and K-77.
Retains the ability to dimerize with JUNB and localization in the nucleus but abolishes DNA-binding.
Glycosyl transferase CAP10 domain-containing protein
Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substrates
Significantly more secreted than wild-type.
Abolished GTP-binding leading tand GTPase activity without affecting localizatiom to the endoplasmic reticulum.
Immunity-related GTPase family M protein 3
Lethal(3)malignant brain tumor-like protein 2
Transcription elongation factor A protein 2
Rho guanine nucleotide exchange factor 6
Impairs localization to secretory granules, promotes location at the TGN, decreases interaction with alpha- and gamma-type adaptin subunits.
Impairs localization to secretory granules, promotes location at the plasma membrane, defective ind gamma endocytosis, highly decreases interaction with alpha- and gamma-type adaptin subunits.
Involved in localization to secretory granules; interaction with CPE
Receptor-type tyrosine-protein phosphatase N2
Necessary for synergistic transcriptional activity with SMAD3
Decreased METTL9-mediated methylation; when associated with A-204.
Decreased METTL9-mediated methylation; when associated with A-216.
Decreased METTL9-mediated methylation; when associated with A-254.
Decreased METTL9-mediated methylation; when associated with A-262.
Homozygous mice have profound B cell immunodeficiency and impaired transition from late pre-B to immature B cell. B cells from mutant mice exhibit a diminished concentration of cytoplasmic free zinc and decreased phosphorylation of signaling molecules downstream of the pre-B cell and B cell receptors.
NACHT and WD repeat domain-containing protein 2
NACHT, LRR and PYD domains-containing protein 1b allele 2
NACHT, LRR and PYD domains-containing protein 1b, C-terminus
NACHT, LRR and PYD domains-containing protein 1b, N-terminus
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Decreased receptor activity in response to MTMT binding, even in the presence of copper.
Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper.
Decreased receptor activity in response to MTMT binding, even in the presence of copper. Shows low constitutive activity in the presence of copper. MTMT binding in the absence of copper results in an inverse agonist effect.
No change in receptor activity in response to MTMT binding in the presence of copper. Complete loss of receptor activity in the absence of copper.
No change in receptor activity in response to MTMT binding in the presence of copper. Decreased receptor activity in the absence of copper.
No change in receptor activity in response to MTMT binding. No change in the copper-induced enhancement of receptor activity.
No receptor activity in response to MTMT binding, even in the presence of copper.
No receptor activity in response to MTMT binding, even in the presence of copper. Little to no expression detected on plasma membrane.
Pleckstrin homology domain-containing family G member 2
Abolishes interaction with WWP2; if associated with F-174.
Abolishes interaction with WWP2; if associated with F-208.
Reduces transcriptional regulatory activity.
Receptor-type tyrosine-protein phosphatase gamma
Interferon-related developmental regulator 1
Phosphoserine; by PAK1, PAK2, PAK3 and PAK5
RAF proto-oncogene serine/threonine-protein kinase
Uncharacterized protein C11orf91 homolog
Almost loss of glycerophosphocholine cholinephosphodiesterase activity. Loss of choline metabolism.
Does not affect Glycerophosphocholine cholinephosphodiesterase activity; when associated withA-393. Does not affect choline metabolism; when associated with A-393.
Does not affect glycerophosphocholine cholinephosphodiesterase activity; when associated with S-412. Does not affect choline metabolism; when associated with S-412.
Glycerophosphocholine cholinephosphodiesterase ENPP6
Highly decreases glycerophosphocholine cholinephosphodiesterase activity. Loss of choline metabolism.
Fails to induce myogenic differentiation in C2C12 cells.
Fails to form disulfide bonds and to induce filopodia-like protrusions.
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Asymmetric dimethylarginine; alternate; by PRMT1
Omega-N-methylarginine; alternate; by PRMT1
Almost complete loss of CTTN-binding and loss of regulation of spine density; when associated with A-540.
Almost complete loss of CTTN-binding and loss of regulation of spine density; when associated with A-543.
Reduced CTTN-binding; when associated with A-599.
Reduced CTTN-binding; when associated with A-602.
Constitutive coactivator of PPAR-gamma-like protein 2
Abolishes phosphorylation, disrupts interaction with PIK3R1 and PIK3R2, no LGALS9-mediated disruption of interaction with BAG6; when associated with F-256.
Abolishes phosphorylation, disrupts interaction with PIK3R1 and PIK3R2, no LGALS9-mediated disruption of interaction with BAG6; when associated with F-263.
Decreases phosphatidylserine binding, abolishes phagocytic activity.
Greatly decreases phosphatidylserine binding.
Hepatitis A virus cellular receptor 2 homolog
Actin, alpha cardiac muscle 1, intermediate form
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
Brefeldin A-inhibited guanine nucleotide-exchange protein 2
Necessary for heme-binding and pri-miRNA processing
Necessary for nuclear localization and retention
Disintegrin and metalloproteinase domain-containing protein 2
Zinc finger and SCAN domain-containing protein 12
Cytosolic Fe-S cluster assembly factor NUBP2
Neuronal PAS domain-containing protein 2
Significant decrease in DNA binding affinity resulting in a loss of the transcriptional activity.
Sufficient for heterodimer formation with BMAL1, E-box binding and for the effect of NADPH
Isoamyl acetate-hydrolyzing esterase 1 homolog
Alanyl-transfer RNA synthetases family profile
Decreases misincorporation of Cys instead of Ala.
Homozygous embryos die at midgestation. Defects are caused by a dramatic increase in production of Ser-mischarged tRNA(Ala).
In sti; homozygous mice display an unkempt sticky appearance of fur and show cerebellar Purkinje cell loss and ataxia; defects are caused by impaired ability to edit incorrectly charged tRNA, resulting in formation of ubiquitinated protein aggregates in cerebellar Purkinje cells and degeneration of these neurons.
26S proteasome non-ATPase regulatory subunit 9
Misfolded, leading to the interaction with TOR1A, ubiquitination and a decrease of the half-life. Impairs intracellular transport. No effect on glycosylation.
LIM homeobox transcription factor 1-alpha
Abolished GTPase activity, promoting localization to lipid droplets.
Abolished localization to pathogen-containing vacuoles.
Does not affect formation of a head-to-head homodimer in presence of GDP.
Impaired formation of a head-to-head homodimer in presence of GDP.
Does not affect binding to diterpenoid derivative 15-oxospiramilactone (S3) inhibitor.
Loss of deubiquitinase activity and binding to diterpenoid derivative 15-oxospiramilactone (S3) inhibitor.
Ubiquitin carboxyl-terminal hydrolase 30
Transcription initiation factor TFIID subunit 3
Maestro heat-like repeat-containing protein family member 2B
Interchain (with C-608 or C-609 in GP1BA)
Polypeptide N-acetylgalactosaminyltransferase 12
Histone-arginine methyltransferase METTL23
Dual specificity mitogen-activated protein kinase kinase 1
Results in hyperphosphorylation of the RAF-dependent sites and prolonged ERK phosphorylation.
Results in hypophosphorylation of the RAF-dependent sites and faster ERK inactivation.
Calcium-binding and coiled-coil domain-containing protein 2
Abolishes ubiquitin phosphorylation; when associated with A-218 and A-361.
Abolishes ubiquitin phosphorylation; when associated with A-218 and A-383.
Abolishes ubiquitin phosphorylation; when associated with A-361 and A-383.
Required for outer membrane localization
Serine/threonine-protein kinase PINK1, mitochondrial
Potassium voltage-gated channel subfamily H member 2
Cyclic AMP-dependent transcription factor ATF-5
Decreases acetylation levels and interaction with CEBPB.
Required for protein stabilization induced by IL1B
Eukaryotic translation initiation factor 3 subunit B
Strongly reduces affinity for MLPH and SYTL4.
RNA-binding motif protein, Y chromosome, family 1 member A1
Trafficking protein particle complex subunit 2-like protein
ATP-sensitive inward rectifier potassium channel 10
Converts the coenzyme specificity from NADP to NAD.
Probable ribosome biogenesis protein RLP24
61 X 10 AA tandem repeats of [NSQ]-[NKQVGA]-[GSAQKRT]-[ASGDTK]-[KGTQSAV]-[KGAED]-[EQVGIPTDMA]-[EGVAS]-[AGVPETNS]-[AQNGPTVS]
In isoform RRp61, isoform RRp1.8, isoform RRp0, isoform RRp2, isoform RRp16.8, isoform RRp15b, isoform RRp10, isoform RRp5.4, isoform RRp15a, isoform RRp47 and isoform RRp41.
Rho-related BTB domain-containing protein 1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
Pleckstrin homology-like domain family A member 1
3 beta-hydroxysteroid dehydrogenase type 7
Polyadenylate-binding protein-interacting protein 2
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Myb-related transcription factor, partner of profilin
Reduction in homodimerization. Abolishes homodimerization; when associated with A-281.
Reduction in homodimerization. Abolishes homodimerization; when associated with P-281.
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Reverses IR-Induced increases in superoxide and genomic Instability in SIRT3-deficient mice.
Superoxide dismutase [Mn], mitochondrial
Low molecular weight phosphotyrosine protein phosphatase
Higher level of processed SREBF1 and SREBF2 when expressed in liver.
Loss of ubiquitination; when associated with R-454.
Loss of ubiquitination; when associated with R-466.
Sterol regulatory element-binding protein cleavage-activating protein
No effect on protein abundance. Decreased reduction by ascorbate.
No effect on protein abundance. Decreased reduction by ascorbate; when associated with A-159.
No effect on protein abundance. Decreased reduction by ascorbate; when associated with A-86.
Transmembrane ascorbate-dependent reductase CYB561
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
ADP-ribosylation factor-like protein 13B
Abolishes palmitoylation and localization to the cilium membrane.
Coiled-coil domain-containing protein 69
Loss of lysyl hydroxylase activity. No effect on glycosyltransferase activity. Mutant mice are born at the expected Mendelian rate and have no visible phenotype, excepting decreased hydroxylysine modifications in type IV collagens in the skin.
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
Required for glycosyltransferase activity
NADPH-dependent 3-keto-steroid reductase Hsd3b5
Abolishes disulfide reductase activity; when associated with A-158; A-161; A-480; A-483; A-588; A-591 and A-700.
Abolishes disulfide reductase activity; when associated with A-158; A-161; A-480; A-483; A-588; A-591 and A-703.
Abolishes disulfide reductase activity; when associated with A-158; A-161; A-480; A-483; A-588; A-700 and A-703.
Abolishes disulfide reductase activity; when associated with A-158; A-161; A-480; A-483; A-591; A-700 and A-703.
Abolishes disulfide reductase activity; when associated with A-158; A-161; A-480; A-588; A-591; A-700 and A-703.
Abolishes disulfide reductase activity; when associated with A-158; A-161; A-483; A-588; A-591; A-700 and A-703.
Abolishes disulfide reductase activity; when associated with A-158; A-480; A-483; A-588; A-591; A-700 and A-703.
Abolishes disulfide reductase activity; when associated with A-161; A-480; A-483; A-588; A-591; A-700 and A-703.
Signal transducer and activator of transcription 5A
O-(3'-phospho-DNA)-tyrosine intermediate
Heparan-alpha-glucosaminide N-acetyltransferase
Abolishes sialic acid transporter activity. Does not affect L-aspartate and L-glutamate transporter activity.
Completely abolishes L-aspartate and L-glutamate transporter activity. Retains appreciable H(+)-coupled sialic acid transporter activity.
cGMP-specific 3',5'-cyclic phosphodiesterase
Eukaryotic translation initiation factor 4E-binding protein 1
In grizzled (gr), mice show a uniformly gray coat color, rather than the expected agouti coat color.
Major facilitator superfamily domain-containing protein 12
Nuclear envelope integral membrane protein 2
Uncharacterized protein C19orf47 homolog
Uncharacterized protein C9orf131 homolog
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
Abrogates ubiquitination activity and the ability to promote DR4- and Fas-induced apoptosis.
Coiled-coil domain-containing protein 50
Gamma-aminobutyric acid receptor subunit delta
Coiled-coil domain-containing protein 80
Gamma-aminobutyric acid receptor subunit beta-2
Cyclic AMP-responsive element-binding protein 3-like protein 2
Loss of S1P cleavage; when associated with A-427.
Loss of S1P cleavage; when associated with V-430.
Processed cyclic AMP-responsive element-binding protein 3-like protein 2
Abolishes channel activity. Alters potassium channel kinetics in heart myocytes. Abolishes the fast component of I(to) in heart ventricle.
Abolishes regulation of neuronal A-type current in response to activation of metabotropic glutamate receptors.
Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well
Interaction with KCNIP1, KCNIP2, and other family members
No effect on the regulation of neuronal A-type current in response to activation of metabotropic glutamate receptors.
Potassium voltage-gated channel subfamily D member 2
Transcription initiation factor TFIID subunit 9
Abolishes interaction with HOMER1. Does not affect enzymatic activity. Fails to associate with the plasma membrane.
Ubiquitin carboxyl-terminal hydrolase 10
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Abolishes formation of a disulfide-linked heterodimer with KCNK2.
Important for increased permeability to Na(+) when K(+) levels are subphysiological
Important for intracellular retention in recycling endosomes
Increases channel expression at the cell membrane, resulting in higher channel activity.
Part of a hydrophobic barrier that is stochastically dewetted and limits ion permeability
Does not affect protein expression and abundance. No effect on cell surface localization and secretion. No effect on interaction with GATA2.
MyoD family inhibitor domain-containing protein
In strain: 020, BALB/c, BALB/cJ, C3H/21BG, C3H/HeJ, CBA/J, MA/M4J and PL/J.
In strain: BALB/cJ, C57BL/6J and MOLF/Ei.
26S proteasome non-ATPase regulatory subunit 13
Abolishes heparan sulfate attachment. Does not affect cell surface location.
Essential for interaction with CBLN1; modulates interaction affinity with NLGN1, NLGN2 and NLGN3; prevents interaction with DAG1/alpha-dystroglycan; modulates interaction with alpha-latrotoxin
Loss of NLGN1-binding. No effect on CBLN1-binding.
No effect on heparan sulfate attachment.
Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding
Soluble lamin-associated protein of 75 kDa
Breast cancer anti-estrogen resistance protein 1
Interchain (with C-92 in IL12A and C-74 in IL23A)
Conserved oligomeric Golgi complex subunit 7
Necessary for targeting to peroxisomes and interaction with PEX19
(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O
Important for metal ion-dependent interaction with integrin
60% of ENPP1 redirected to apical surface in epithelial cells. 75% of ENPP1 redirected to apical surface in epithelial cells; abrogation of increased NPP activity in oestoblastic matrix vesicles; when associated with A-32.
70% of ENPP1 redirected to apical surface in epithelial cells; abrogation of increased NPP activity in oestoblastic matrix vesicles. 75% of ENPP1 redirected to apical surface in epithelial cells; abrogation of increased NPP activity in oestoblastic matrix vesicles; when associated with A-31.
Abolished ability to hydrolyze 2',3'-cGAMP without affecting ability to hydrolyze ATP.
Abolishes all phosphodiesterase activity. 10% activity can be restored by addition of Zn(2+) ions. Abolishes formation of nucleotidylated intermediate.
Abolishes all phosphodiesterase activity. 15% activity can be restored by addition of Zn(2+) ions. Abolishes formation of nucleotidylated intermediate.
Abolishes all phosphodiesterase activity. 60% activity can be restored by addition of Zn(2+) ions. Abolishes formation of nucleotidylated intermediate.
Abolishes all phosphodiesterase activity. Abolishes formation of nucleotidylated intermediate.
Decreases phosphodiesterase activity by 40%. Decreased formation of nucleotidylated intermediate.
Decreases phosphodiesterase activity by 50%. Decreased formation of nucleotidylated intermediate.
Decreases phosphodiesterase activity by 90%. Accumulates nucleotidylated intermediate.
Decreases phosphodiesterase activity by 95%. 65% activity can be restored by addition of Zn(2+) ions. Accumulates nucleotidylated intermediate.
Decreases phosphodiesterase activity by 95%. Abolishes formation of nucleotidylated intermediate.
Decreases phosphodiesterase activity by 95%. Accumulates nucleotidylated intermediate.
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form
Little change in baolateral sorting in epithelial cells.
Mice display a low bone mass density and show a striking joint disease and calcification of blood vessels. Probably affects protein stability.
Nearly abolishes activity with nucleotide phosphates. Confers very low activity with lysophospholipids.
No change in increased NPP activity in oestoblastic matrix vesicles.
No effect on basolateral sorting in epithelial cells.
Strongly decreased phosphodiesterase activity.
No effect on predominant location in the cytosol.
Strongly increased location in the nucleus.
Loss of interaction with UBQLN1; when associated with A-176.
Loss of interaction with UBQLN1; when associated with A-177.
In isoform 5, isoform 8, isoform 9 and isoform 10.
Constitutively active mutant locked in the active GTP-bound form; alters endocytic recycling.
Dominant negative mutant locked in the inactive GDP-bound form; partially relocalizes to the Golgi and alters endocytic recycling.
Abolishes interaction with PIK3R1. Strongly reduced phosphorylation of PLCG2. No effect on binding to THOC5.
Loss of kinase activity. Abolishes binding to THOC5.
Macrophage colony-stimulating factor 1 receptor
May alter protein folding or stability. Loss of kinase activity. No effect on interaction with PIK3R1.
No effect on binding to THOC5. Slightly reduced enhancement of cell proliferation.
Reduced interaction with CBL. Prolonged signaling, due to reduced internalization and degradation. Reduced interaction with FYN. Promotes cell proliferation. Reduced autophosphorylation at Tyr-807.
Reduced kinase activity. Strongly reduced phosphorylation of PLCG2. Diminishes binding to THOC5.
4 X 7 AA tandem repeats of T-S-T-A-Q-A-[GR]
Abolishes proteolytic processing. Gain of function mutant.
Impaired recycling affecting its internalization, leading to decreased activity on the plasma surface.
Loss of function. Does not prevent proteolytic processing.
Enhanced surface expression and a lower localization to endosomal vesicles.
Large neutral amino acids transporter small subunit 4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Can mediate pyridoxine transport; when associated with G-88; I-92; T-94; W-95; S-169 and N-174.
Can mediate pyridoxine transport; when associated with Q-87; G-88; I-92; T-94; S-169 and N-174.
Can mediate pyridoxine transport; when associated with Q-87; G-88; I-92; T-94; W-95 and N-174.
Can mediate pyridoxine transport; when associated with Q-87; G-88; I-92; T-94; W-95 and S-169.
Can mediate pyridoxine transport; when associated with Q-87; G-88; I-92; W-95; S-169 and N-174.
Can mediate pyridoxine transport; when associated with Q-87; G-88; T-94; W-95; S-169 and N-174.
Can mediate pyridoxine transport; when associated with Q-87; I-92; T-94; W-95; S-169 and N-174.
Abolishes MYD88-binding and response to microbial cell wall components.
Loss of tyrosine phosphorylation. Abolishes interaction with FYN and GRB2.
Receptor-type tyrosine-protein phosphatase O
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3); alternate
RAB7A-interacting MON1-CCZ1 complex subunit 1
Decreases the interaction with AXIN1, GSK3B-mediated beta-catenin phosphorylation, cytoplasmic beta-catenin accumulation and Wnt-mediated transcription activation.
PPPSP motif; required for interaction with AXIN1
Zinc finger BED domain-containing protein 3
Loss of interaction with CALM1. No effect on desumoylase activity.
Significanly reduced interaction with SUMO2.
Significanly reduced interaction with SUMO2. Loss of desumoylase activity.
Abolished interaction witzh STK39/SPAK and subsequent phosphorylatuon and activation.
Reduced potassium ion transmembrane transport.
Causes obesity in mice. Obesity develops with normal food intake and reduced energy expenditure. Mice are cold intolerant with defective brown/beige adipose tissues. Reduces interaction with CEBPA.
Outer dynein arm-docking complex subunit 3
Does not affect core iron sulfur assembly complex formation. Abolishes sulhydratation.
Iron-sulfur cluster assembly enzyme ISCU
Mediates ISCU dimerization and de novo [2Fe-2S] cluster assembly
Protein-arginine deiminase (PAD) N-terminal
Protein-arginine deiminase (PAD) central
Proline, histidine and glycine-rich protein 1
Required for interaction with TLK1 and DYNLL1/LC8
Serine/threonine-protein kinase tousled-like 2
Leucine-rich repeat-containing protein 14B
Guanine nucleotide-binding protein subunit alpha-13
Necessary for nuclear speckle localization
Alters RRM 1 stability. Abolishes regulation of alternative splicing.
Heterogeneous nuclear ribonucleoprotein L-like
DNA-directed RNA polymerase I subunit RPA49
MTRF1L release factor glutamine methyltransferase
UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Inter-alpha-trypsin inhibitor heavy chain H1
Accumulation within the nucleus; when associated with A-289.
Accumulation within the nucleus; when associated with A-291.
Ankyrin repeat domain-containing protein 54
Increases the cytoplasmic protein content; when associated with A-98.
Increases the cytoplasmic protein content; when associated with A-99.
Cation-dependent mannose-6-phosphate receptor
Loss of SAMM50-binding. Reduced affinity toward OPA1. No effect on IMMT-binding.
Interchain (between alpha and beta chains)
Volume-regulated anion channel subunit LRRC8D
Spindle and kinetochore-associated protein 3
DNA annealing helicase and endonuclease ZRANB3
Leucine-rich repeat-containing protein 24
Abolishes interaction with APBA1. Abolishes transport of vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.
Solute carrier family 2, facilitated glucose transporter member 4
Ankyrin repeat domain-containing protein 9
Important role in both nutrient sensing and binding/regulation of IMPDH2
Somatostatin/Cortistatin C-terminal domain-containing protein
Affects the subcellular localization. Detected in the nucleus.
Factor associated with metabolism and energy
Dolichol-phosphate mannosyltransferase subunit 1
70% reduction in binding to YWHAZ and increased nuclear localization.
Coiled-coil domain-containing protein 103
Vacuolar protein sorting-associated protein 8 homolog
Abolishes maturation and cleavage by CORIN.
Does not affect maturation and cleavage by CORIN.
Important for degradation of atrial natriuretic peptide by IDE
CCR4-NOT transcription complex subunit 4
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
Phosphatidylcholine:ceramide cholinephosphotransferase 1
In Mot; male sterility characterized by reduced sperm output, and sperm with aberrant motility and short tails.
Almost no EGF-mediated phosphorylation, greatly reduced cellular transformation, and reduced AP1 activity by 20%; when associated with A-325. No effect on PDGF-stimulated enhancement of transcriptional activity. Completely abolishes PDGF-stimulated enhancement of transcriptional activity; when associated with A-232; A-325;and A-374.
Almost no EGF-mediated phosphorylation, greatly reduced cellular transformation, and reduced AP1 activity by 20%; when associated with A-331. No effect on PDGF-stimulated enhancement of transcriptional activity. Completely abolishes PDGF-stimulated enhancement of transcriptional activity; when associated with A-232; A-331 and A-374.
Basic motif; required for the activation of phospholipid synthesis, but not for CDS1-binding
Complete loss of activation of phospholipid synthesis. No effect on CDS1-binding.
Disrupts interaction with SMARCB1, SMARCD1, ARID1A and JUN.
Enhanced EGF- and RSK-mediated transformation; when associated with D-362.
Enhanced EGF- and RSK-mediated transformation; when associated with D-374.
Enhanced EGF- and RSK-mediated transformation; when associated with E-362.
Increased enhancement of EGF- and RSK-mediated transformation; when associated with E-374.
No effect on PDGF-stimulated enhancement of transcriptional activity. Completely abolishes PDGF-stimulated enhancement of transcriptional activity; when associated with A-232; A-325 and A-331.
No effect on PDGF-stimulated enhancement of transcriptional activity. Completely abolishes PDGF-stimulated enhancement of transcriptional activity; when associated with A-325; A-331 and A-374.
No effect on activation of phospholipid synthesis, nor on CDS1-binding.
No effect on activation of phospholipid synthesis.
Phosphoserine; by MAPK1, MAPK3 and RPS6KA3
Reduced phosphorylation by ERK. Reduced AP1 activity by 65%.
Abolishes interaction with PTPN11/SHP-2.
Important for interaction with phosphotyrosine-binding proteins
In W37; impaired protein stability and loss of kinase activity.
In W42; loss of kinase activity and impaired internalization after exposure to KITLG/SCF.
Loss-of-function mutation abolishing ligand binding.
Mast/stem cell growth factor receptor Kit
Mice display white fur, hearing loss, anemia and mast cell deficiency, plus sterility in both males and females.
Armadillo repeat-containing X-linked protein 5
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Di-leucine motif; mediates lysosomal localization
Vesicular integral-membrane protein VIP36
Decreases interaction with SCN8A in the absence of calcium.
Necessary and sufficient for interaction with PCP4
Abolishes phosphatidylinositol 3,4,5-trisphosphate binding.
Increased phosphatidylinositol 3,4,5-trisphosphate binding.
Strongly reduces phosphatidylinositol 3,4,5-trisphosphate binding.
Improved binding of dioxygen and carbon monoxide to the iron atom.
Isoglutamyl cysteine thioester (Cys-Gln)
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4
KN motif and ankyrin repeat domain-containing protein 4
Loss of deubiquitinating activity, does not disassemble TRAF6:UBE2N ubiquitin ligase complex, abolioshes TAX1BP1 interaction with UBE2N.
Required for lysosomal localization and for TRAF2 lysosomal degradation
Required for proteasomal degradation of UBE2N and UBE2D3, TRAF6 deubiquitination, and TAX1BP1 interaction with UBE2N
Sufficient for inhibitory activity of TNF-induced NF-kappa-B activity
Tumor necrosis factor alpha-induced protein 3
Phosphothreonine; by MTOR, NEK6 and NEK7
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
Cyclic AMP-responsive element-binding protein 3-like protein 4
Processed cyclic AMP-responsive element-binding protein 3-like protein 4
Mitochondrial import inner membrane translocase subunit Tim8 A
Dual specificity mitogen-activated protein kinase kinase 7
In isoform 2, isoform 4, isoform 5 and isoform 6.
ATP-dependent 6-phosphofructokinase, liver type
Essential for interaction with GOLGA2/GM130
Cleavage; by caspase-3, caspase-6 and caspase-7
Displays constitutive phospholipid scramblase activity.
In 1DA mutant; abolished cleavage by caspase, preventing phospholipid scramblase activity.
Calcineurin-binding protein cabin-1 MEF2-binding
Developmental pluripotency-associated protein 2/4 C-terminal
Developmental pluripotency-associated protein 4
Reduces the interaction with CRYAB and MTOR.
Significant loss in AMPK-mediated phosphorylation.
V-type proton ATPase catalytic subunit A
Almost complete loss in cinnamaldehyde or cold-evoked response.
Alternate; transient; in hyperoxia; unknown whether inter- or intrachain
Cysteine sulfenic acid (-SOH); transient; in hyperoxia
Important decrease in cinnamaldehyde or cold-evoked response.
Important residue for activation by the scorpion wasabi receptor toxin
Key residue for activation by the scorpion wasabi receptor toxin
Transient receptor potential cation channel subfamily A member 1
Very important decrease in cinnamaldehyde or cold-evoked response.
Abolishes one phosphorylation site. Decreases phosphorylation by PKA.
Associates almost exclusively with the membrane. Loss of MAP2K2 and MAP2K2 binding and recruitment to the membrane. Loss of MAP kinase-mediated inhibition of ELK1 phosphorylation. No effect on the interaction with YWHAE.
Constitutive targeting to the plasma membrane; when associated with A-297. No effect on interaction with MARK3. Abolishes phosphorylation by MARK3.
Constitutive targeting to the plasma membrane; when associated with A-392.
Decrease in MARK3 binding; when associated with A-397. No effect on interaction with MARK3.
Decrease in MARK3 binding; when associated with A-401. Abolishes interaction with MARK3. Reduces phosphorylation of S-392 by MARK3.
Impairs interaction with BRAF and association with membrane ruffles; when associated with A-78.
Loss of ATP binding and reduces MAPK1 and MAPK3 phosphorylation levels. Loss of kinase activity towards MAP2K1 in vitro. Abnormal constitutive interaction with CRAF. No effect on the interaction with BRAF and MAP2K1.
No effect on ATP binding and MAPK1 and MAPK3 phosphorylation levels. No effect on the interaction with MAP2K1.
No effect on phosphorylation of S-392 by MARK3.
No effect on the interaction with MAP2K1, MAP2K2 and YWHAE. Abolishes interaction with BRAF. Abolishes location at membrane ruffles.
Partial decrease in MAP2K1 and MAP2K2 binding. No effect on the interaction with YWHAE.
Reduces interaction with MARK3. Reduces phosphorylation of S-392 by MARK3.
Reduces phosphorylation of S-392 by MARK3.
Severe decrease in MAP2K1 and MAP2K2 binding. No effect on the interaction with YWHAE.
A disintegrin and metalloproteinase with thrombospondin motifs 13
Eukaryotic translation initiation factor 4E-binding protein 3
Ubiquitin/ISG15-conjugating enzyme E2 L6
POU domain, class 4, transcription factor 3
In dyl; negative regulation of lens epithelial cell proliferation; positive regulation of lens fiber cell differentiation; positive regulation of epithelial cell apoptotic process; loss of sequence-specific DNA binding.
Cytochrome b5 domain-containing protein 1
Essential to induce neural progenitor proliferation
Leucine-rich repeats and immunoglobulin-like domains protein 1
Mitochondrial coenzyme A diphosphatase NUDT8
WAS/WASL-interacting protein family member 2
Decrease in ACHE tetramer recruitment to membrane rafts.
Does not abolish the localization of ACHE.
No effect on ACHE tetramer recruitment to membrane rafts.
No effect on ACHE tetramer recruitment to membrane rafts; when associated with 138-A--A-142.
No effect on ACHE tetramer recruitment to membrane rafts; when associated with A-131.
Histidine kinase/HSP90-like ATPase domain-containing protein
Loss of interaction with YWHAB and defects in the completion of cytokinesis.
Loss of localization to the perinuclear region. Loss of translocation to the nucleus upon PMA stimulation.
G-protein coupled receptor family C group 5 member D
SPARC-related modular calcium-binding protein 1
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
Tumor necrosis factor receptor superfamily member 16
In a mouse model for harlequin ichthyosis (HI), homozygous mice are embryonic lethal but occasionally pups are found in the first few hours after birth but die and are severely dehydrated and fail to suckle normally. Homozygous pups show hallmarks of HI desease including hyperkeratosis, abnormal extracellular lipid lamellae and defects in cornified envelope processing. At 14.5 dpc and 15.5 dpc homozygous embryos appear normal; however from 16.5 dpc onwards they are characterized by an absence of normal skin folds around the trunk and limbs. As development progressed, embryos develop a taut, thick epidermis and multiple contractures affecting the limbs. Late stage embryos are smaller.
In a mouse model for harlequin ichthyosis (HI), smooth skin (smsk) mutant mice show a pronounced perinatal lethal skin phenotype in 25% of the offspring and newborn mutant pups die within a few hours after birth, and appear severely dehydrated with dry cracking skin. Smsk homozygous mutants embryos show a normal appearance at 14.5 dpc, but at 16.5 dpc develop a partial absence of normal skin folds around the trunk and limbs, and by 18.5 dpc develop a taut, thick skin and limb contractures.
Motile sperm domain-containing protein 3
Coiled-coil domain-containing protein 62
Loss of interaction with GOPC. Does not localize to the acrosome. Homozygous mutant mice are infertile and show deformed sperm with reduced motility.
Abolishes ligand binding and reduces transactivation; when associated with W-270.
In strain: C3H/HeJ and DBA/2J; does not change transcriptional activity.
Reduced lipid binding and transactivation. Abolishes ligand binding and reduces transactivation; when associated with F-345.
Strongly reduced transactivation; when associated with D-440.
Strongly reduced transactivation; when associated with D-442.
Coiled-coil domain-containing protein 96
Large ribosomal subunit protein uL6 N-terminal
Increases activity towards short-chain fatty acids.
Lowers activity towards short-chain fatty acids.
Lowers activity towards short-chain fatty acids. Strong increase in activity towards medium chain fatty acids.
Actin, alpha skeletal muscle, intermediate form
Membrane-associated phosphatidylinositol transfer protein 2
Partial inhibition of BMP2-induced cytodifferentiation; when associated with E-170.
Partial inhibition of BMP2-induced cytodifferentiation; when associated with E-219.
Rescues the inhibitory effects of ASPN on BMP2-induced cytodifferentiation.
Remains stable, even in the face of severe hypoxia.
T-cell acute lymphocytic leukemia protein 1 homolog
Abolishes FGF2-induced lens fiber differentiation via inhibition of FGF-mediated ERK1/2 phosphorylation.
Decreased selectivity for monovalent cations and increased permeability for Ca(2+).
Decreases channel sensitivity to inhibition by ATP.
Mediates modulation by decavanadate and PIP2-binding
Near loss of channel sensitivity to inhibition by ATP.
Strongly decreased selectivity for monovalent cations and increased permeability for Ca(2+).
Strongly decreases channel sensitivity to inhibition by ATP.
Transient receptor potential cation channel subfamily M member 4
Rab3 GTPase-activating protein non-catalytic subunit
Rab3GAP regulatory subunit C-terminal domain-containing protein
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ubiquitin carboxyl-terminal hydrolase 17-like protein B
Aldehyde dehydrogenase, dimeric NADP-preferring
Axonemal dynein light intermediate polypeptide 1
Phosphatidylinositol transfer protein alpha isoform
Cell adhesion molecule-related/down-regulated by oncogenes
Guanine nucleotide-binding protein G(i) subunit alpha-3
Ubiquinone biosynthesis protein COQ9, mitochondrial
Interleukin-1 receptor type 2, membrane form
Interleukin-1 receptor type 2, soluble form
With pyrrolidone carboxylic acid at Gln-438.
Fails to interacts with AGO2. Decreases nuclear localization.
Abolishes thioredoxin reductase, glutaredoxin and gluthioine reductase activities.
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Thioredoxin reductase activity reduced to 21%. Glutaredoxin activity reduced to 14%. Glutathione reductase activity reduced to 18%.
Branched-chain-amino-acid aminotransferase, cytosolic
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2
EF-hand calcium-binding domain-containing protein 10
Long-chain fatty acid transport protein 4
Death effector domain-containing protein
Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix
N-terminal domain; essential for its chromatin remodeling activity
Mitotic spindle assembly checkpoint protein MAD2A
Required for assuming the closed conformation and for interaction with CDC20
Fibronectin type III and SPRY domain-containing protein 2
Neutrophil gelatinase-associated lipocalin
CDK2-associated and cullin domain-containing protein 1
Interaction with histone H3, CHAF1B, and HIRA
CDK-activating kinase assembly factor MAT1
Calcium-activated chloride channel regulator 2
Complete loss of PAH transport activity.
Decreased cell surface expression level and PAH transport activity. 80% decrease of PAH transport activity; when associated with A-49; A-122 and A-183. Complete loss of PAH transport activity; when associated with A-49; A-78; A-99; A-122; A-172; A-183; A-200; A-362; A-335; A-379; A-402 and A-427.
Decreased cell surface expression level and PAH transport activity. Complete loss of PAH transport activity; when associated with A-49; A-78; A-99; A-122; A-172; A-200; A-362; A-335; A-379; A-402; A-427 and A-434.
Decreased cell surface expression level and PAH transport activity. Complete loss of PAH transport activity; when associated with A-49; A-78; A-99; A-172; A-183; A-200; A-362; A-335; A-379; A-402; A-427 and A-434.
Decreased cell surface expression level and PAH transport activity. Complete loss of PAH transport activity; when associated with A-78; A-99; A-122; A-172; A-183; A-200; A-362; A-335; A-379; A-402; A-427 and A-434.
Tumor necrosis factor-inducible gene 6 protein
Vacuolar protein sorting-associated protein VTA1 homolog
Important for autoinhibition of adenylyltransferase activity
Myb/SANT-like DNA-binding domain-containing protein 4
Protein phosphatase 1 regulatory subunit 26
Glycine N-acyltransferase-like protein Keg1
Mesenteric estrogen-dependent adipogenesis protein
Echinoderm microtubule-associated protein-like 5
Required for microtubule binding and for localization to the centrosomes
Tumor necrosis factor ligand superfamily member 11, membrane form
Tumor necrosis factor ligand superfamily member 11, soluble form
LHFPL tetraspan subfamily member 3 protein
Mas-related G-protein coupled receptor member B5
Guanine nucleotide-binding protein G(z) subunit alpha
Abolishes interaction with elongin BC complex; when associated with F-179.
Abolishes interaction with elongin BC complex; when associated with P-175.
Loss of IL-6 signal transduction suppression. No effect on binding to TYK2.
Loss of JAK signal transduction suppression.
Loss of JAK signal transduction suppression. Destabilization of SOCS1.
Loss of JAK signal transduction suppression. Reduced binding to JH1.
Loss of LIF signal transduction suppression. Loss of binding to KIT. No effect on binding to VAV.
Loss of binding to JH1/Y-1007 of JAK2 and loss of signal transduction suppression.
No effect on JAK signal transduction inhibition nor on binding to JH1.
No effect on JAK signal transduction suppression nor on binding to JH1.
No effect on JAK signal transduction suppression.
No effect on LIF signal transduction suppression.
Some loss of JAK signal transduction signaling. Reduced binding to JH1.
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Histone-lysine N-methyltransferase SUV39H2
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Loss of isomerase activity. No phenotype when introduced in mice, animals are viable and fertile with no microcephaly or defective cortical lamination; no splicing defect.
Peptidyl-prolyl cis-trans isomerase-like 1
Does not phosphorylated by MAPK14/p38-alpha-activated MAPKAPK2/MK2. Does not affect localization. Does not affect interaction with ZCCHC8.
Chromodomain-helicase-DNA-binding protein 4
Causes a failure of Shh processing leading to retention of the immature glycosylated protein within the endoplasmic reticulum of transfected cells; causes a temperature-dependent conformational change that allows Shh to bind Ptch1 at 4 or 32 degrees Celsius but not at 37 degrees Celsius; drastically reduces signaling potency in chicken embryo neural plate explant assays.
Does not affect signaling activity in any of Shh signaling assays and causes no apparent defects in cholesterol-mediated autoprocessing reactions.
Introduces a cleavage site for a furin-like protease resulting in abnormal protein processing; cleavage at this site removes 11 amino acids from the N-terminal domain and reduces affinity of Shh for Ptch1 and signaling potency in assays using chicken embryo neural plate explants and mouse C3H10T1/2 stem cells.
Moderately reduces Ptch1 binding in vitro and signaling potency in chicken embryo neural plate explant assays compared with wild-type sequence.
Shows no change in activities at different temperatures.
Strongly reduces effects of in vivo overexpression; impairs multimer formation; does not affect subcellular location to lipid rafts. Homozygous mice are characterized by a smaller size and holoprosencephaly at 10.5 dpc, and shortening of limbs at 13.5 dpc. They die soon after birth.
HERV-H LTR-associating protein 1 homolog
Fasciculation and elongation protein zeta-1
Leucine-rich repeat-containing protein 4B
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Mice carrying this mutant show narrowed dental pulp cavities, increased dentin thickness, and abnormal tooth attrition, as well as anomalies in the number and organization of dentinal tubules, indicating dysplasia of the mineralized dentin; the width of the predentin zone is reduced in heterozygous animals or null in homozygotes, with significantly increased numbers of odontoblasts in the pulp cavity compared to wild-type mice.
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial
Transactivation AF-1; required for ligand-independent transactivation function
Transactivation AF-2; required for ligand-dependent transactivation function; mediates interaction with CCAR2
Transcription initiation factor IIA alpha chain
Transcription initiation factor IIA beta chain
Transcription initiation factor IIA subunit 1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
Selection and upkeep of intraepithelial T-cells protein 8
Coiled-coil domain-containing protein 116
Highly decreases Notch signaling pathway. Multi-ubiquitination pattern is reduced, although it does appear to be mono-ubiquitinated. Interacts with MIB1. Loss of cis and trans interaction with NOTCH1. Increases its association with lipid raft microdomains.
Highly decreases Notch signaling pathway. Multi-ubiquitination pattern is reduced, although it does appear to be mono-ubiquitinated. Interacts with MIB1. Loss of cis interaction with NOTCH1.
Not phosphorylated; when associated with A-693 and A-696. Not phosphorylated and doesn't prevent phosphorylation at S-693 and S-696. Reduces NOTCH1 transactivation; when associated with A-693 and A-696. Reduces cell surface levels of proteins; when associated with A-693 and A-696. Increases ectodomain shedding; when associated with A-693 and A-696.
Not phosphorylated; when associated with V-638 and A-693. Not phosphorylated and doesn't prevent phosphorylation at T-638 and S-693, Reduces NOTCH1 transactivation; when associated with V-638 and A-693. Reduces cell surface levels of proteins; when associated with V-638 and A-693. Increases ectodomain shedding; when associated with V-638 and A-693.
Not phosphorylated; when associated with V-638 and A-696. Not phosphorylated and prevents phosphorylation at S-696. Reduces NOTCH1 transactivation; when associated with V-638 and A-696. Reduces cell surface levels of proteins; when associated with V-638 and A-696. Increases ectodomain shedding; when associated with V-638 and A-696.
Abolishes conductivity; when associated with A-349 and A-350.
Abolishes conductivity; when associated with A-349 and A-351.
Abolishes conductivity; when associated with A-350 and A-351.
Abolishes sensitivity to sulfhydryl modification.
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Reduces affinity for cAMP and impairs tetramerization.
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Cyclic nucleotide phosphodiesterase catalytic
TATA box-binding protein-associated factor RNA polymerase I subunit C
Translocating chain-associated membrane protein 2
Methylmalonic aciduria type A homolog, mitochondrial
Strain BALB/c. Without methionine sulfoxide.
Strain C57BL/6. With 1 methionine sulfoxide.
Strain C57BL/6. Without methionine sulfoxide.
Coiled-coil domain-containing protein 138
Inhibits interaction with GLI2. Decreased nuclear colocalization with GLI2. No effect on DNA-binding. Decreased Ihh-induced transcriptional activity and transcription coactivator activity with GLI2.
No effect on protein stability, inhibited sumoylation, increased transcriptional activity; when associated with R-229.
No effect on protein stability, inhibited sumoylation, increased transcriptional activity; when associated with R-258.
No effect on sumoylation; when associated with 6-A--A-9; A-237; A-243 and A-320.
No effect on sumoylation; when associated with 6-A--A-9; A-237; A-243 and A-521.
No effect on sumoylation; when associated with 6-A--A-9; A-237; A-320 and A-521.
No effect on sumoylation; when associated with 6-A--A-9; A-243; A-320 and A-521.
No effect on sumoylation; when associated with A-237; A-243; A-320 and A-521.
Aryl hydrocarbon receptor nuclear translocator
Decreases heterodimer formation with EPAS1. Decreases heterodimer formation with HIF1A. Impairs heterodimer formation with EPAS1; when associated with A-366. Impairs heterodimer formation with HIF1A; when associated with A-366. Significantly destabilizes ARNT?s heterodimeric interactions with both NPAS1 and NPAS3. Compromises SIM1:ARNT heterodimer stability. Does not compromise NPAS4:ARNT heterodimer stability. Does not compromise AHR:ARNT heterodimer stability.
Decreases heterodimer formation with EPAS1. Decreases heterodimer formation with HIF1A. Significantly destabilizes ARNT?s heterodimeric interactions with both NPAS1 and NPAS3. Compromises SIM1:ARNT heterodimer stability. Does not compromise NPAS4:ARNT heterodimer stability. Does not compromise AHR:ARNT heterodimer stability.
Highly reduces transcription activity. Impairs interaction with AHR. Impairs heterodimer formation with EPAS1. Impairs heterodimer formation with HIF1A. Significantly destabilizes ARNT?s heterodimeric interactions with both NPAS1 and NPAS3. Compromises SIM1:ARNT heterodimer stability. Compromise NPAS4:ARNT heterodimer stability. Compromise AHR:ARNT heterodimer stability.
Impairs heterodimer formation with EPAS1. Impairs heterodimer formation with HIF1A. Significantly destabilizes ARNT?s heterodimeric interactions with both NPAS1 and NPAS3. Compromises SIM1:ARNT heterodimer stability. Compromise NPAS4:ARNT heterodimer stability. Compromise AHR:ARNT heterodimer stability.
Impairs heterodimer formation with EPAS1. Markedly decreases heterodimer formation with HIF1A. Significantly destabilizes ARNT?s heterodimeric interactions with both NPAS1 and NPAS3. Compromises SIM1:ARNT heterodimer stability. Does not compromise NPAS4:ARNT heterodimer stability. Does not compromise AHR:ARNT heterodimer stability.
Interfers with transcription factor activity.
Markedly decreases heterodimer formation with EPAS1. Decreases heterodimer formation with HIF1A. Significantly destabilizes ARNT?s heterodimeric interactions with both NPAS1 and NPAS3. Compromises SIM1:ARNT heterodimer stability. Does not compromise NPAS4:ARNT heterodimer stability. Does not compromise AHR:ARNT heterodimer stability.
Markedly decreases heterodimer formation with EPAS1. Markedly decreases heterodimer formation with HIF1A. Impairs heterodimer formation with EPAS1; when associated with N-448. Impairs heterodimer formation with HIF1A; when associated with N-448. Significantly destabilizes ARNT?s heterodimeric interactions with both NPAS1 and NPAS3. Compromises SIM1:ARNT heterodimer stability. Does not compromise NPAS4:ARNT heterodimer stability. Does not compromise AHR:ARNT heterodimer stability.
Markedly decreases heterodimer formation with EPAS1. Markedly decreases heterodimer formation with HIF1A. Significantly destabilizes ARNT?s heterodimeric interactions with both NPAS1 and NPAS3. Compromises SIM1:ARNT heterodimer stability. Does not compromise NPAS4:ARNT heterodimer stability. Does not compromise AHR:ARNT heterodimer stability.
Mediates the transcription activity and dimerization of the AHR:ARNT complex
Reduces DNA binding. Decreases transcription factor activity.
Reduces transcription activity. Markedly reduces interaction with AHR. Impairs heterodimer formation with EPAS1. Markedly decreases heterodimer formation with HIF1A. Significantly destabilizes ARNT?s heterodimeric interactions with both NPAS1 and NPAS3. Compromises SIM1:ARNT heterodimer stability. Compromise NPAS4:ARNT heterodimer stability. Compromise AHR:ARNT heterodimer stability.
Required for heterodimer formation with EPAS1
Required for heterodimer formation with HIF1A
Far upstream element-binding protein C-terminal
SANT and BTB domain regulator of class switch recombination
Abolished cystine transport. Abolished interaction with components of the v-ATPase and Ragulator complexes. Does not affect ability to lysosomal localization of LAMP2A.
protonated residue following cystine-binding
O-linked (Xyl...) (keratan sulfate) threonine
Decreases protein abundance. Strong decreases of cell surface localization. Strong decreases on alanine uptake activity.
No effect on protein abundance. Almost complete loss of cell surface localization. Decreases alanine uptake activity.
No effect on protein abundance. Increases localization to the cell membrane. Increases alanine uptake activity.
No effect on protein abundance. No effect on cell surface expression. Decreases alanine uptake activity.
No effect on protein abundance. No effect on cell surface localization. Decreases alanine uptake activity.
No effect on protein abundance. No effect on cell surface localization. Increases alanine uptake activity.
No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity.
No effect on protein abundance. Strong decrease of cell surface localization. Decreases alanine uptake.
No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake activity.
No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake.
Sodium-dependent neutral amino acid transporter B(0)AT3
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
Requires 2 nucleotide substitutions; in T-haplotype.
Chemokine and involved in interaction with ITGAV:ITGB3 and ITGA4:ITGB1
Inactive C-alpha-formylglycine-generating enzyme 2
Almost abolishes cAMP-binding. Interaction with KCNK2 is not inhibited by cAMP.
Insulin receptor-related protein alpha chain
Insulin receptor-related protein beta chain
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)
Essential for TNFSF13B/TALL1/BAFF/BLyS binding
Tumor necrosis factor receptor superfamily member 13C
Tumour necrosis factor receptor 13C TALL-1 binding
Mitochondrial mRNA pseudouridine synthase Rpusd3
E3 ubiquitin-protein ligase RBX1, N-terminally processed
N-acetylalanine; in E3 ubiquitin-protein ligase RBX1, N-terminally processed
T-cell surface glycoprotein CD8 beta chain
Mitochondrial outer membrane protein SLC25A46
10-fold less potently activated by the Scolopendra mutilans RhTx toxin.
13-fold less potently activated by the Scolopendra mutilans RhTx toxin.
17-fold less potently activated by the Scolopendra mutilans RhTx toxin.
8-fold less potently activated by the Scolopendra mutilans RhTx toxin.
Phosphoserine; by PKC/PRKCE and PKC/PRKCZ
Required for PIP2-mediated channel inhibition
Transient receptor potential cation channel subfamily V member 1
Sufficient for transactivation activity; sufficient for interaction with NOTCH1
Zinc finger MIZ domain-containing protein 1
General transcription factor IIH subunit 3
Has no effect on trafficking from endosome to TGN.
Impaired endocytosis associated with retention at the plasma membrane.
Impaired trafficking from endosome to TGN.
Protein-glucosylgalactosylhydroxylysine glucosidase
Results in exclusive localization to early endosomes and no effect on ability to promote LPS-induced IL6 and CCL5 production; when associated with E-15 and E-17.
Results in exclusive localization to early endosomes and no effect on ability to promote LPS-induced IL6 and CCL5 production; when associated with E-7 and E-15.
Results in exclusive localization to early endosomes and no effect on ability to promote LPS-induced IL6 and CCL5 production; when associated with E-7 and E-17.
Results in relocalization from membrane to cytosol; impairs ability to promote LPS-induced IL6 and CCL5 production.
TIR domain-containing adapter molecule 2
Major facilitator superfamily domain-containing protein 4A
Abolishes enzyme activity. Unable to mediate serine depalmitoleoylation of WNT proteins.
Palmitoleoyl-protein carboxylesterase NOTUM
V-set and transmembrane domain-containing protein 4
Short transient receptor potential channel 4-associated protein
ATP-binding cassette sub-family G member 3
Hypoxia-inducible lipid droplet-associated protein
Required for targeting to lipid droplets
Cilia- and flagella-associated protein 418
10 X 13 AA approximate tandem repeats, RPT domain
Cleavage; by furin-like proprotein convertase
Forms abnormal block-like assemblies devoid of fibrillar sheet structure. Does not affect protein maturation. Does not affect fibril formation.
Forms abnormal block-like assemblies devoid of fibrillar sheet structure; when associated with 304-P--T-429 del.
Corticotropin-releasing factor receptor 2
Disrupts internal salt bridge and abrogates ligand recognition.
A disintegrin and metalloproteinase with thrombospondin motifs 20
Elongation of very long chain fatty acids protein 4
Loss of N-glycosylation. No effect on fatty acid elongase activity.
Loss of localization to the endoplasmic reticulum. Loss of fatty acid elongase activity.
Ubiquitin-like domain-containing CTD phosphatase 1
Leucine-rich repeat and transmembrane domain-containing protein 1
Alpha-carbonic anhydrase domain-containing protein
In ingls; loss of interaction with Pikfyve but not with Fig4.
Mediates interaction with the PDZ domain of NOS1
N-terminal EF-hand calcium-binding protein 1
Cilia- and flagella-associated protein 206
Amiloride-sensitive sodium channel subunit beta
Eukaryotic translation initiation factor 4E type 2
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15); alternate
Low-density lipoprotein receptor-related protein 12
Glucose-fructose oxidoreductase domain-containing protein 2
Alpha-ketoglutarate dehydrogenase component 4
Zinc finger and BTB domain-containing protein 7C
Uncharacterized protein KIAA1755 homolog
CKLF-like MARVEL transmembrane domain-containing protein 4
Abolished RAC1 GTPase activity. Abolished ability to induce neurite branching. No effect on filopodia biogenesis and neurite outgrowth.
Loss of the ability to induce filopodia and to initiate neurite outgrowth. Abolished interaction with GPHN.
SLIT-ROBO Rho GTPase-activating protein 2
Ankyrin repeat and LEM domain-containing protein 2
Involved in the ligation of specific target proteins
Endosome/lysosome-associated apoptosis and autophagy regulator 1
Acidic leucine-rich nuclear phosphoprotein 32 family member B
NF-kappa-B inhibitor-interacting Ras-like protein 2
Does not regulate formation of MARDO membraneless compartment; when associated with A-154.
Does not regulate formation of MARDO membraneless compartment; when associated with A-161.
In 4CS mutant; abolished binding to the 3'-UTR of maternal mRNAs; when associated with S-269, S-296 and S-313.
In 4CS mutant; abolished binding to the 3'-UTR of maternal mRNAs; when associated with S-269, S-296 and S-341.
In 4CS mutant; abolished binding to the 3'-UTR of maternal mRNAs; when associated with S-269, S-313 and S-341.
In 4CS mutant; abolished binding to the 3'-UTR of maternal mRNAs; when associated with S-296, S-313 and S-341.
Mimics phosphorylation state; does not regulate formation of MARDO membraneless compartment; when associated with D-154.
Mimics phosphorylation state; does not regulate formation of MARDO membraneless compartment; when associated with D-161.
Tuberoinfundibular peptide of 39 residues
Loss of phosphorylation but no loss of autophagic function; when associated with A-163.
Loss of phosphorylation but no loss of autophagic function; when associated with A-165.
Phosphatidylinositol 3-kinase catalytic subunit type 3
Glycosyltransferase 8 domain-containing protein 1
Almost completely abolishes KLC1-binding.
Marked reduction in KLC1-binding; when associated with A-903. Marked alteration in anterograde axonal transport.
Marked reduction in KLC1-binding; when associated with A-972. Marked alteration in anterograde axonal transport.
Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site
Ubiquitin carboxyl-terminal hydrolase isozyme L4
Central conserved domain (CCD); required for localization to endoplasmic reticulum exit sites
Polypeptide N-acetylgalactosaminyltransferase 2
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form
Abolishes glycosylation; when associated with Q-114, Q-120 and Q-312.
Abolishes glycosylation; when associated with Q-114, Q-120 and Q-326.
Abolishes glycosylation; when associated with Q-114, Q-312 and Q-326.
Abolishes glycosylation; when associated with Q-120, Q-312 and Q-326.
Fibrillin unique N-terminal (FUN) domain
Abolishes DNA double-strand break repair and subsequent regulation of apoptosis. Abolishes localization to the mitochondrion. No effect on localization to centrosomes or centrosome integrity.
Abolishes localization to the nucleus and enhances localization to the mitochondrion. Reduces stalled replication fork restart. Abolishes ATR-mediated phosphorylation of S-151. No effect on phosphorylation and activation of ATR. No effect on localization to centrosomes or centrosome integrity.
No effect on localization at replication forks, nascent DNA degradation following DNA damage, restart of stalled replication forks or levels of DNA damage.
Reduces restart of stalled replication forks and cells show an increase in DNA double strand breaks. Decreases phosphorylation of ATR at 'S-428'. Reduces TRIM25 ubiquitination of BLM and subsequent localization to DNA replication forks. Reduces phosphorylation and activation of ATR. No effect on Filia distribution at replication forks or nascent DNA degradation following DNA damage. Not effect on interaction with OOEP.
Required for interaction with NUMA1 and regulation of apoptosis in response to DNA damage
Does not inhibit interaction with ZNF473 and histone 3'-end processing.
Does not inhibit interaction with ZNF473. Reduces weakly histone 3' end processing.
Does not inhibit interaction with ZNF473. Strongly reduces histone 3' end processing.
U7 snRNA-associated Sm-like protein LSm11
Breast cancer metastasis-suppressor 1-like protein
Loss of interaction with ANK2. Loss of colocalization and cotransportation on motile vesicles with ANK2.
Impairs protection against hydrogen peroxide-induced toxicity.
Increased sensitivity to hydrogen peroxide-induced toxicity.
U5 small nuclear ribonucleoprotein 40 kDa protein
Protein mono-ADP-ribosyltransferase PARP11
4-trimethylaminobutyraldehyde dehydrogenase
Aldehyde dehydrogenase domain-containing protein
Mothers against decapentaplegic homolog 7
No effect on stability, nuclear localization or inhibitory function in TGFB signaling. Abolishes transcriptional activity.
cAMP-dependent protein kinase inhibitor gamma
Decreased localization of SQSTM1/p62 to damaged mitochondria; when associated with R-25; R-33 and 122-R-R-123.
Decreased localization of SQSTM1/p62 to damaged mitochondria; when associated with R-25; R-33 and R-66.
Decreased localization of SQSTM1/p62 to damaged mitochondria; when associated with R-25; R-66 and 122-R-R-123.
Decreased localization of SQSTM1/p62 to damaged mitochondria; when associated with R-33; R-66 and 122-R-R-123.
Involved in ceramide and phosphatidylcholine binding. Critical for channel structural stability and gating
No effect on localization of SQSTM1/p62 to damaged mitochondria.
Voltage-dependent anion-selective channel protein 1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
ATP-binding cassette sub-family E member 1
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1 and SUMO2)
Repressor of RNA polymerase III transcription MAF1 homolog
Tigger transposable element-derived protein 3
Leucine-rich region; critical for dimer formation and for interaction with RFXAP
PxLPxI/L motif; mediates interaction with RFXANK
U3 small nucleolar ribonucleoprotein protein MPP10
Peroxisomal leader peptide-processing protease
Peroxisomal leader peptide-processing protease, 10 kDa form
Peroxisomal leader peptide-processing protease, 49 kDa form
Carcinoembryonic antigen-related cell adhesion molecule 2
Does not affect mitochondrion localization.
Fails to dephosphorylate PGP in vitro. Does not affect level of Akt phosphorylation.
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
Necessary for mitochondria recruitment at the lipid droplet surface
Multiple coagulation factor deficiency protein 2 homolog
Required for interaction with INCENP and BIRC5
Required to form a minimal CPC core complex that localizes to the central spindle and midbody and properly executes the role of the CPC during cytokinesis
Thioredoxin-dependent peroxide reductase, mitochondrial
Interaction with 7-methylguanosine mRNA cap structure
Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motif
von Willebrand factor A domain-containing protein 3A
Gamma-aminobutyric acid receptor-associated protein-like 2
Abolishes phosphorylation by PKA. No change in protein levels. Loss of protein stability on PKA stimulation mediated repression. No change in interaction with HDAC4 in response to PKA; when associated with A-121.
Abolishes phosphorylation by PKA. No change in protein levels. Loss of protein stability on PKA stimulation. Loss of PKA-mediated repression. No change in interaction with HDAC4 in response to PKA; when associated with A-190.
Loss of calpain/Cdk5-mediated neuron apoptosis.
Caspase activity and apoptosis inhibitor 1
Mitochondrial 2-oxodicarboxylate carrier
Mediates targeting and association with DCVs
Isoaspartyl peptidase/L-asparaginase alpha chain
Isoaspartyl peptidase/L-asparaginase beta chain
Loss of phosphorylation by PKG (in vitro). No effect on location at cell membrane.
Abolishes outwardly-rectifying currents.
Di-leucine internalization motif; mediates targeting to late endosome and lysosome membranes
IP motif; mediates targeting to recycling endosomes
Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Mediates proton transfer from the protein to the inner aqueous phase
Polyadenylate-binding protein-interacting protein 2B
rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1
Calcium permeable stress-gated cation channel 1
Does not affect interaction with ATG16L1. Induces lipidation of LC3.
Abolishes binding to PP1 but has no effect on binding to glycogen synthase, glycogen phosphorylase or glycogen; when associated with A-85.
Abolishes binding to PP1 but has no effect on binding to glycogen synthase, glycogen phosphorylase or glycogen; when associated with A-87.
Abolishes binding to glycogen synthase and glycogen phosphorylase but has no effect on binding to PP1 or glycogen; when associated with A-247.
Abolishes binding to glycogen synthase and glycogen phosphorylase but has no effect on binding to PP1 or glycogen; when associated with A-250.
Protein phosphatase 1 regulatory subunit 3C
Bone morphogenetic protein receptor type-1A
Reduced glycosylation and increased protein stability; when associated with Q-314 and Q-373.
Reduced glycosylation and increased protein stability; when associated with Q-373 and Q-373.
Reduced glycosylation and increased protein stability; when associated with Q-73 and Q-314.
receptor protein serine/threonine kinase
Single-pass membrane and coiled-coil domain-containing protein 3
Acyl-CoA dehydrogenase/oxidase N-terminal
Disintegrin and metalloproteinase domain-containing protein 32
Troponin C, slow skeletal and cardiac muscles
Interaction with the PRC2/EED-EZH2 complex
Loss of activity due to the incapacity to bind the regulatory subunit DNMT3L.
Loss of activity. Strongly reduces substrate binding.
Prevents accumulation in pericentric heterochromatin.
Reduces DNA-binding capacity. No effect on activity.
Reduces activity about 15-fold. Loss of substrate binding.
Reduces activity about 2-fold. Reduces DNA-binding capacity.
Reduces activity about 20-fold. Loss of substrate binding.
Reduces activity about 3-fold. Reduces DNA-binding capacity.
Reduces activity about 30-fold. Reduces DNA-binding capacity.
Reduces activity about 5-fold. Reduces DNA-binding capacity. Abolished cysteine-methylation.
Reduces activity about 6-fold. Reduces DNA-binding capacity.
Strongly reduces substrate binding. No effect on activity.
Instead of the formation of an intermediate complex with a thiol ester bond between ATG7 (E1-like enzyme) and GABARAPL1 (MAP1LC3, GABARAP or GABARAPL; substrates), a stable complex with an O-ester bond is formed.
Ubiquitin-like modifier-activating enzyme ATG7
Ubiquitin-like modifier-activating enzyme Atg7 N-terminal
Abolished guanosine exchange factor (GEF) activity for Ran.
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Abolishes E3 ubiquitin-protein ligase activity; when associated with A-15.
Abolishes E3 ubiquitin-protein ligase activity; when associated with L-12.
Abolished cleavage and activation; when associated with A-198.
Abolished cleavage and activation; when associated with A-23.
Required for SUMO paralog-specific binding
Ubiquitin carboxyl-terminal hydrolase 25
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
ATP synthase-coupling factor 6, mitochondrial
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
NEDD4-like E3 ubiquitin-protein ligase WWP2
FYVE, RhoGEF and PH domain-containing protein 2
Loss of early endosome localization; when associated with K-454.
Loss of early endosome localization; when associated with T-455.
No effect on early endosome localization and reduced JNK1 activation; when associated with A-287.
No effect on early endosome localization and reduced JNK1 activation; when associated with A-288.
Rho-related BTB domain-containing protein 2
Sufficient for inhibiting alpha-7 nAChR currents
4 X 5 AA tandem repeats of Q-K-A-[APS]-X
COX assembly mitochondrial protein 2 homolog
Enhanced transcriptional activation; Greatly enhanced transcriptional activation; when associated with A-15.
Enhanced transcriptional activation; Greatly enhanced transcriptional activation; when associated with A-68.
No effect on transcriptional activation.
Nuclear receptor subfamily 2 group C member 2
Some repression of transcriptional activation; Repressed transcriptional activity by about 10-fold; when associated with E-19.
Some repression of transcriptional activation; Repressed transcriptional activity by about 10-fold; when associated with E-68.
Required to release iHOPS from membranes
Transmembrane and ubiquitin-like domain-containing protein 1
Abolishes interaction with ZAP70, and its inhibitory function.
Does not affect its inhibitory function.
Guanylate cyclase soluble subunit beta-1
Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization
Decreased monoglycylation activity; when associated with E-104.
Decreased monoglycylation activity; when associated with E-106.
Decreased monoglycylation activity; when associated with E-93.
Decreased monoglycylation activity; when associated with E-96.
Decreased monoglycylation activity; when associated with N-328.
Decreased monoglycylation activity; when associated with N-330.
Essential for specifying initiation versus elongation step of the polyglycylase activity
Deleted in malignant brain tumors 1 protein
Impairs S-nitrosylation. Abolishes S-nitrosylation; when associated with A-262.
Impairs S-nitrosylation. Abolishes S-nitrosylation; when associated with A-274.
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Uncharacterized protein C11orf16 homolog
Meiosis-specific coiled-coil domain-containing protein MEIOC
Transcription initiation factor TFIID subunit 6
Heterogeneous nuclear ribonucleoprotein H
Heterogeneous nuclear ribonucleoprotein H, N-terminally processed
N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H, N-terminally processed
Coiled-coil domain-containing protein 15
Almost abolishes interaction with BIRC2; when associated with A-292.
Almost abolishes interaction with BIRC2; when associated with A-294.
Important for interaction with BIRC2 and BIRC3
Significant reduction of apoptotic activity.
Interchain (between non-catalytic and catalytic chains)
Serine protease hepsin non-catalytic chain
Pre-B-cell leukemia transcription factor 2
Dipeptidyl peptidase 1 exclusion domain chain
Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
Sodium- and chloride-dependent taurine transporter
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
No effect on RANBP10-binding. Loss of interaction with NEMP1.
Strongly decreases interaction with RANGRF. Partial decrease in RANBP10-binding. No effect on interaction with NEMP1 and KPNB1.
Neuronal acetylcholine receptor subunit alpha-5
N-terminal auto-inhibitory domain; necessary for interaction with SMARCA4/BRG1
Necessary for interaction with CREBBP and for the recruitment of CREBBP to the nuclear bodies
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Doublesex- and mab-3-related transcription factor C2
Mediates endoplasmic reticulum retention
Thioredoxin domain-containing protein 16
In L-5178-Y cell line; methotrexate-resistant, requires 2 nucleotide substitutions.
In a form with an abnormally low affinity for methotrexate.
In isoform 1b, isoform 1d, isoform 2b, isoform 2d, isoform 3b and isoform 3d.
In isoform 1c, isoform 1d, isoform 2c, isoform 2d, isoform 3c and isoform 3d.
In isoform 2a, isoform 2b, isoform 2c and isoform 2d.
In isoform 3a, isoform 3b, isoform 3c and isoform 3d.
No effect on interaction with histone H3.
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Geminin coiled-coil domain-containing protein 1
Inosine-5'-monophosphate dehydrogenase 1
Absence of phosphorylation. Reduced protein degradation. Reduced self-renewal ability in ES cells. No change in FBXW4 binding. Loss of FBXW8 binding.
Absence of sumoylation. Enhanced protein degradation. Reduced self-renewal ability in ES cells. 55% lower expression of YES1.
Absence of sumoylation. Enhanced protein degradation. Reduced self-renewal ability in ES cells. 70% lower expression of YES1. Reduced DNA binding. No change in nuclear location. No change in nuclear localization. Absence of sumoylation; when associated with R-215 and R-244.
Loss of MAPK9 binding. Absence of Ser-347 phosphorylation.
Loss of self-renewal ability in iPS cells.
No change in DNA binding. Loss of self-renewal ability in iPS cells. No change in nuclear location.
No change in DNA binding. Loss of self-renewal ability in iPS cells. No change in nuclear location. No loss of ability to bind SOX2. Reduced levels of CHD4 and SMARCA4 in a POU5F1 pulldown assay.
No change in DNA binding. No change in nuclear location.
No change in DNA binding. No loss of self-renewal ability in iPS cells. No change in nuclear location.
No change in DNA binding. Reduced self-renewal ability in iPS cells. No change in nuclear location.
No change in sumoylation. No change in sumoylation; when associated with R-215. Loss of sumoylation; when associated with R-118 and R-215. No change in nuclear localization; when associated with R-118 and R-215.
No change in sumoylation; when associated with R-244. Loss of sumoylation. No change in nuclear localization; when associated with R-118 and R-244.
POU domain, class 5, transcription factor 1
Reduced DNA binding. Loss of self-renewal ability in iPS cells. No change in nuclear location.
Abolishes barbed-end actin-binding without affecting actin bundling activity.
Does not detach from actin following BDNF treatment; when associated with A-624.
Does not detach from actin following BDNF treatment; when associated with A-628.
Epidermal growth factor receptor kinase substrate 8
Impairs both actin capping and bundling activities.
Mimicks phosphorylation state; promotes detachment from actin in absence of BDNF treatment; when associated with E-624.
Mimicks phosphorylation state; promotes detachment from actin in absence of BDNF treatment; when associated with E-628.
Transforming growth factor beta-2 proprotein
Odontogenic ameloblast-associated protein
Zinc finger SWIM domain-containing protein 4
Adheres to and takes up L.monocytogenes InlA coated beads.
Increased affinity for L.monocytogenes InlA. Greatly increased affinity; when associated with P-172.
Required for binding alpha, beta and gamma catenins
Signal peptidase complex catalytic subunit SEC11C
Beta-1,3-N-acetylglucosaminyltransferase radical fringe
Pulmonary surfactant-associated protein D
Spermatid-specific linker histone H1-like protein
Proline-rich region; mediates mutually exclusive interactions with itself and NOXA1
Homeodomain-interacting protein kinase 3
Impairs catalytic activity and abolishes interaction with DAXX.
Loss of kinase activity and impaired activation of SF1.
Required for localization to nuclear speckles
SUMO interaction motifs (SIM); required for nuclear localization and kinase activity
Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of ligand binding
Loss of kinase activity; no effect on FIZ1-binding.
Receptor-type tyrosine-protein kinase FLT3
Zinc finger HIT domain-containing protein 1
C2 calcium-dependent domain-containing protein 4C
Phosphotyrosine; by autocatalysis, LYN and JAK2
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
FXYD domain-containing ion transport regulator 4
Pseudouridylate synthase TRUB2, mitochondrial
Cilia- and flagella-associated protein 300
Secreted frizzled-related sequence protein 4
Abolishes binding to TELO2-phosphopeptide.
No effect on binding to TELO2-phosphopeptide.
Confers cellular localization similar to full-length form
Zinc finger CCCH domain-containing protein 13
Leydig cell tumor 10 kDa protein homolog
Signal recognition particle subunit SRP54
BAG-similar domain, required and sufficient for interaction with UBL4A
Sufficient for the delivery of client proteins to the endoplasmic reticulum
Insulin growth factor-like family member
Lipid-binding serum glycoprotein N-terminal
SH3 domain-binding glutamic acid-rich-like protein 3
Regulating synaptic membrane exocytosis protein 1
Inactive glycosyltransferase 25 family member 3
Dehydrogenase/reductase SDR family member 7C
Zinc finger CCHC domain-containing protein 14
Serine/arginine repetitive matrix protein 3
Cell growth-regulating nucleolar protein
Binding site for the uncoating ATPase, involved in lattice disassembly
Involved in binding clathrin light chain
Sodium/potassium-transporting ATPase subunit beta-2
May mediate active transcriptional repression
Cation channel sperm-associated auxiliary subunit delta
BMP/retinoic acid-inducible neural-specific protein 1
Rho guanine nucleotide exchange factor 39
High affinity immunoglobulin epsilon receptor subunit alpha
Microtubule-associated protein RP/EB family member 3
Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal
In lst; abolishes DNA binding and transcriptional activation.
When overexpressed ubiquitously in conditional knockin mice, perinatally lethal; when overexpressed in osteoblasts in conditional knockin mice, produces a severe skeletal phenotype marked by a drastic increase in cortical thickness due to an enhanced endosteal bone formation; when overexpressed in osteoclasts in conditional knockin mice, no effect on bone hemostasis.
ATP-binding cassette sub-family C member 10
Prevents phosphorylation and activation by STK11/LKB1 complex.
General transcription factor II-I repeat domain-containing protein 1
In isoform 1, isoform 3, isoform 7, isoform 9 and isoform 10.
In isoform 3, isoform 4, isoform 8 and isoform 10.
Probable E3 ubiquitin-protein ligase DTX3
AT-rich interactive domain-containing protein 3A
Synaptonemal complex central element protein 2
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
Almost no change in fusion-facilitating activity.
Confers ability to bind ferric iron and carbonate; when associated with R-143.
Confers ability to bind ferric iron and carbonate; when associated with Y-207.
S-acyl fatty acid synthase thioesterase, medium chain
Mainly expressed in the cytoplasm; when associated with A-7 and A-10.
Mainly expressed in the cytoplasm; when associated with A-7 and A-8.
Mainly expressed in the cytoplasm; when associated with A-8 and A-10.
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
Abolishes binding of PIAS1 and PIAS2. Dramatically reduces sumoylation and abolishes AXIN1-mediated JNK activation. No effect on homodimerization nor on Wnt-signaling.
Decreased sumoylation followed by increased ubiquitination; when associated with A-858.
Decreased sumoylation followed by increased ubiquitination; when associated with A-861.
Greatly reduced GSK3B-mediated phosphorylation and large effect on the inhibitory activity in Wnt-signaling; when associated with A-480 and A-492.
Greatly reduced GSK3B-mediated phosphorylation; when associated with A-480 and A-485.
Greatly reduced GSK3B-mediated phosphorylation; when associated with A-485 and A-492.
Little effect on inhibitory activity on Wnt-signaling.
No effect on phosphorylation. Little effect on inhibitory activity on Wnt-signaling.
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Pleckstrin homology domain-containing family F member 2
Mitochondrial tRNA methylthiotransferase CDK5RAP1
Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membrane
Sufficient for translocalization to p62 bodies/ALIS
WD repeat and FYVE domain-containing protein 3
Cytoplasmic polyadenylation element-binding protein 3
Polypeptide N-acetylgalactosaminyltransferase 15
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
BTB/POZ domain-containing protein KCTD19
Significantly impaired guanine nucleotide exchange factor activity on ARF6 in PC12 cells.
Abolishes protein-kinase activity. Does not affect ubiquitination by PELI3.
Does not prevent polyubiquitination by PELI3.
Mimics phosphorylation; does not promote stabilization of RIPK2.
Receptor-interacting serine/threonine-protein kinase 2
Propionyl-CoA carboxylase alpha chain, mitochondrial
X-linked interleukin-1 receptor accessory protein-like 2
Increased mechanosensitive channel activity in Tmem87a-expressing cells; when associated with G-292.
Increased mechanosensitive channel activity in Tmem87a-expressing cells; when associated with L-271.
Prostate and testis expressed protein 14
Transcription elongation factor A protein-like 8
Fibronectin type III domain-containing protein 4
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Knockin mice display compromised mucus barriers, dysbiosis with reduced bacterial diversity, as well as susceptibility to intestinal inflammation.
Medium-chain acyl-CoA ligase ACSF2, mitochondrial
DNA replication complex GINS protein PSF3
Not essential for folding and stability of GINS complex, but may regulate accessibility to the central complex pore
tRNA (guanine(26)-N(2))-dimethyltransferase
Double C2-like domain-containing protein alpha
V-type proton ATPase 116 kDa subunit a 1
Zinc finger HIT domain-containing protein 2
Transport and Golgi organization protein 6 homolog
Pleckstrin homology domain-containing family H member 3
Bone morphogenetic protein receptor type-1B
Loss of kinase activity. No effect on cell membrane location.
No effect on kinase activity. No effect on cell membrane location.
Ral GTPase-activating protein subunit alpha-1
(Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)
ATP-binding cassette sub-family B member 10, mitochondrial
Does not affect ABCB10 glutathionylation.
Nuclear envelope abnormalities specific to neurons.
Phosphoserine; by RPS6KA1, RPS6KA3, DAPK1 and PASK
Loss of enzymatic activity, interaction with IPO11, nuclear import, and effect on cell growth.
Trafficking protein particle complex subunit 4
Involved in ceramide and phosphatidylcholine binding
Voltage-dependent anion-selective channel protein 2
Abolished binding to N6-methyladenosine (m6A)-containing RNAs; when associated with A-378.
Abolished binding to N6-methyladenosine (m6A)-containing RNAs; when associated with A-429.
Loss of phosphorylation, interaction with EZR and localization to the uropodium.
No loss of phosphorylation or localization to the uropodium. Loss of interaction with EZR.
Reduced phosphorylation. Significant loss of phosphorylation; when associated with A-343.
Reduced phosphorylation. Significant loss of phosphorylation; when associated with A-347.
Required for interaction with EZR, MSN and RDX and for co-localization to microvilli
Significant reduction in interaction with RDX.
DNA-directed RNA polymerase II subunit RPB3
27 X 6 AA repeats of [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV]
Heterogeneous nuclear ribonucleoprotein M
Insulin-like growth factor-binding protein 4
Nucleoporin Nup133/Nup155-like C-terminal
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Glycoprotein integral membrane protein 1
Cell death-inducing p53-target protein 1
Adenosine deaminase domain-containing protein 1
CCR4-NOT transcription complex subunit 11
Interaction with U4 snRNA and U4atac snRNA
N-acetylthreonine; in NHP2-like protein 1, N-terminally processed
NHP2-like protein 1, N-terminally processed
Maternal embryonic leucine zipper kinase
C-Jun-amino-terminal kinase-interacting protein 4
S-adenosylmethionine sensor upstream of mTORC1
Solute carrier organic anion transporter family member 2A1
N-linked (GlcNAc...) (keratan sulfate) asparagine
Pre-mRNA cleavage complex 2 protein Pcf11
Loss of cell membrane recruitment following EGF stimulation.
Killer cell lectin-like receptor subfamily I member 1
Polypeptide N-acetylgalactosaminyltransferase 11
Queuine tRNA-ribosyltransferase accessory subunit 2
Sodium-coupled monocarboxylate transporter 1
Dexamethasone-induced Ras-related protein 1
Cholesterol side-chain cleavage enzyme, mitochondrial
Abolishes interaction with ATP2A1/SERCA1.
Does not affect interaction with ATP2A1.
Homozygous mutant mice exhibit retinal degeneration.
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
GTP:AMP phosphotransferase AK3, mitochondrial
G protein-coupled receptor associated sorting protein 3
Interaction with CCNA1 and CCNA1/CDK2 complex; essential for CDK2 inhibitory activity
Impairs post-transfer editing activity but no effect on aminoacylation activity; when associated with A-154.
Impairs post-transfer editing activity but no effect on aminoacylation activity; when associated with A-158.
Disrupts interaction with VPS35:VPS29 dimer; no endosomal localization.
Disrupts interaction with VPS35:VPS29 dimer; no endosomal localization; when associated with S-245.
Disrupts interaction with VPS35:VPS29 dimer; no endosomal localization; when associated with S-247.
No endosomal localization; no effect on interaction with VPS35:VPS29 dimer.
No endosomal localization; no effect on interaction with VPS35:VPS29 dimer; when associated with E-199.
No endosomal localization; no effect on interaction with VPS35:VPS29 dimer; when associated with S-197.
Vacuolar protein sorting-associated protein 26B
Maestro heat-like repeat-containing protein family member 7
Uncharacterized protein C10orf120 homolog
Does not affect ability to promote piRNA biosynthesis.
Glycerol-3-phosphate acyltransferase 2, mitochondrial
Glycoside hydrolase family 31 N-terminal
Eukaryotic initiation factor 4A-III, N-terminally processed
N-acetylalanine; in Eukaryotic initiation factor 4A-III, N-terminally processed
Oxysterol-binding protein-related protein 1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Protein mono-ADP-ribosyltransferase PARP16
Mice develop hair and nail defects resembling pachyonychia congenita.
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
Enoyl-CoA delta isomerase 1, mitochondrial
May be protonated during monocarboxylate transport
Keratin, type II cytoskeletal 2 epidermal
Sterile alpha motif domain-containing protein 13
LysM and putative peptidoglycan-binding domain-containing protein 3
Abolishes the binding to PDCD1. Costimulates proliferation and IFNG production of T-cells.
Significantly reduces the binding to PDCD1.
Ankyrin repeat domain-containing protein 40
Coiled-coil domain-containing protein 33
DNA polymerase subunit gamma-2, mitochondrial
Phosphatidylinositol 3-kinase regulatory subunit gamma
U6 snRNA-associated Sm-like protein LSm4
DnaJ homolog subfamily C member 30, mitochondrial
Barrier-to-autointegration factor, N-terminally processed
N-acetylthreonine; in Barrier-to-autointegration factor, N-terminally processed
Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2
Abolishes binding to histone H3K9me3 and ability to repress transcription of target genes.
Required for affinity and specificity for 5-mCpG sequence
Required for formation of a 5-methylcytosine-binding pocket
Required to confer preferential recognition of cytosine over thymine
Required to discriminate between hemimethylated DNA versus symmetrically methylated DNA
Myeloid differentiation primary response protein MyD88
Prevents dimerization of death domains and activation of JNK and NF-kappa-B.
Inhibits interaction with AXIN1 and ZBED3.
Loss of phosphorylation; No inhibition of activity and constitutively active.
Phosphoserine; by PKB/AKT1, RPS6KA3 and SGK3
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
rRNA N6-adenosine-methyltransferase ZCCHC4
Abolishes retention in the endoplasmic reticulum so that the protein is secreted.
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
Interaction with TSG101, VPS37B and VPS28
Forkhead-associated domain-containing protein 1
Inhibitor of nuclear factor kappa-B kinase subunit beta
Phosphoserine; by TBK1, PKC/PRKCZ and PDPK1
cAMP-dependent protein kinase catalytic subunit beta
Markedly reduced sumoylation; when associated with R-43.
Markedly reduced sumoylation; when associated with R-459.
Fails to assemble into disulfide-bonded multimers, while still exhibiting non-covalently associated high molecular weight oligomeric states in solution; retains binding to LRP8 and VLDR receptors but fails to show signaling activity.
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Does not affect interaction with ADGRA2.
Reversion-inducing cysteine-rich protein with Kazal motifs
Necessary and sufficient for the interaction with SQSTM1
Progressive ataxia associated with Purkinje cell death. Retinal thinning due to photoreceptor cell death.
Mitochondrial import receptor subunit TOM5 homolog
Interacts with SPRY1, SPRY2, SPRY3 and SPRY4
Cytosolic iron-sulfur assembly component 2A
CKLF-like MARVEL transmembrane domain-containing protein 7
Oxidative stress-responsive serine-rich protein 1
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase 2 alpha chain
S-adenosylmethionine decarboxylase 2 beta chain
Schiff-base intermediate with substrate; via pyruvic acid
ATP-binding cassette sub-family D member 2
Amyloid-beta A4 precursor protein-binding family A member 2
In fragile-red; loss of endosomal membrane localization; 2-fold decrease in ferric-chelate reductase activity.
Loss of ferric-chelate reductase activity.
Nonsense-mediated mRNA decay factor SMG5
Torsin-1A-interacting protein 2, isoform IFRG15
Membrane-bound transcription factor site-1 protease
General transcription factor 3C polypeptide 6
17-beta-hydroxysteroid dehydrogenase type 3
Beta/gamma crystallin domain-containing protein 3
Attenuated repression of Adam10 transcription.
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
Phosphodiesterase 4 upstream conserved regions (UCR)
Trans-Golgi network integral membrane protein 1
Growth arrest and DNA damage-inducible protein GADD45 alpha
Potassium ion selectivity and permeability
Cytidine and dCMP deaminase domain-containing protein 1
Testis-specific Y-encoded-like protein 5
Glycyl serine ester (Ser-Gly) (interchain with G-Cter in ubiquitin); alternate
H-2 class I histocompatibility antigen, D-B alpha chain
In K-less, no effect on ubiquitination; when associated with R-55, R-155, R-170, R-197, R-210, R-220, R-267 and R-277.
In K-less, no effect on ubiquitination; when associated with R-55, R-92, R-155, R-170, R-197, R-210, R-220 and R-267.
In K-less, no effect on ubiquitination; when associated with R-55, R-92, R-155, R-170, R-197, R-210, R-220 and R-277.
In K-less, no effect on ubiquitination; when associated with R-55, R-92, R-155, R-170, R-197, R-210, R-267 and R-277.
In K-less, no effect on ubiquitination; when associated with R-55, R-92, R-155, R-170, R-197, R-220, R-267 and R-277.
In K-less, no effect on ubiquitination; when associated with R-55, R-92, R-155, R-170, R-210, R-220, R-267 and R-277.
In K-less, no effect on ubiquitination; when associated with R-55, R-92, R-155, R-197, R-210, R-220, R-267 and R-277.
In K-less, no effect on ubiquitination; when associated with R-55, R-92, R-170, R-197, R-210, R-220, R-267 and R-277.
In K-less, no effect on ubiquitination; when associated with R-92, R-155, R-170, R-197, R-210, R-220, R-267 and R-277.
In Ld KCST-less, strongly impairs ubiquitination; when associated with I-337; R-340; 350-A--A-356 and 360-R-R-361. In Ld tail 1S, restores ubiquitination; when associated I-337; R-340; 350-A--A-352; A-356 and 360-R-R-361.
In Ld KCST-less, strongly impairs ubiquitination; when associated with R-332; I-337 and 360-R-R-361.
In Ld KCST-less, strongly impairs ubiquitination; when associated with R-332; I-337; 350-A--A-356 and 360-R-R-361. In Ld tail 1S, restores ubiquitination; when associated R-332; I-337; 350-A--A-352; A-356 and 360-R-R-361.
In Ld KCST-less, strongly impairs ubiquitination; when associated with R-332; I-337; R-340 and 350-A--A-356. In Ld tail 1S, restores ubiquitination; when associated R-332; I-337; R-340; 350-A--A-352; A-356 and 360-R-R-361.
In Ld KCST-less, strongly impairs ubiquitination; when associated with R-332; R-340; 350-A--A-356 and 360-R-R-361. In Ld tail 1S, restores ubiquitination; when associated R-332; R-340; 350-A--A-352; A-356 and 360-R-R-361.
In Ld tail 1S, restores ubiquitination; when associated R-332; I-337; R-340 and A-356.
In Ld tail 1S, restores ubiquitination; when associated R-332; I-337; R-340; A-356 and 360-R-R-361.
Does not inhibit interaction with OAZ1. Reduces interaction with OAZ1; when associated with A-116. Strongly reduces interaction with OAZ1 and unable to abrogate the inhibitory effect of OAZ1 on ornithine decarboxylase (ODC) activity and polyamine uptake; when associated with A-139 and A-140.
Does not inhibit interaction with OAZ1. Reduces interaction with OAZ1; when associated with A-142.
Necessary for polyamine uptake stimulation
Strongly reduces interaction with OAZ1 and unable to abrogate both the inhibitory effect of OAZ1 on ornithine decarboxylase (ODC) activity and polyamine uptake; when associated with A-139 and A-142.
Strongly reduces interaction with OAZ1 and unable to abrogate both the inhibitory effect of OAZ1 on ornithine decarboxylase (ODC) activity and polyamine uptake; when associated with A-140 and A-142.
ST]-E-Y-X(3)-F motif 1; required for efficient microtubule binding and stabilization
ST]-E-Y-X(3)-F motif 2; required for efficient microtubule binding and stabilization
ST]-E-Y-X(3)-F motif 3; required for efficient microtubule binding
ST]-E-Y-X(3)-F motif 4; required for efficient microtubule binding and stabilization
A disintegrin and metalloproteinase with thrombospondin motifs 4
Heterogeneous nuclear ribonucleoprotein A1
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
N-acetylserine; in Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
Probable crossover junction endonuclease EME2
Zinc finger translocation-associated protein
Abolishes phosphorylation, abolishes CD44 splicing regulation; when associated with A-58 and A-71.
Abolishes phosphorylation, abolishes CD44 splicing regulation; when associated with A-58 and A-84.
Abolishes phosphorylation, abolishes CD44 splicing regulation; when associated with A-71 and A-84.
KH domain-containing, RNA-binding, signal transduction-associated protein 1
Necessary for TATA box-bound TBP complex formation
Putative glutathione-specific gamma-glutamylcyclotransferase 2
Leucine-rich repeat-containing protein 2
Retinoid-inducible serine carboxypeptidase
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Impairs interaction with F-actin; when assocoated with A-128.
Impairs interaction with F-actin; when assocoated with A-131.
Interchain (with C-759 in SUN1); alternate
Increase in the kinase activation level.
Eukaryotic translation initiation factor 1A
Notch-regulated ankyrin repeat-containing protein
Reduced Lemd2 protein levels. Disorganization of heterochromatin associated with the nuclear envelope in cardiomyocytes. Increased DNA double-strand breaks in the heart. Dilation of the atrial and ventricular chambers, severe systolic dysfunction and cardiac fibrosis leading to premature death. No defects in skeletal muscle observed.
Required for nuclear retention and interaction with LMNA isoform C
Serine beta-lactamase-like protein LACTB, mitochondrial
Calcium and integrin-binding family member 2
Causes deafness; decreases interaction with TMC1 and TMC2; abolishes localization of TMC1 to stereocilia; reduces localization of TMC2 to stereocilia; reduces calcium permeability and conductance of MET channels in hair cells.
Causes deafness; decreases interaction with TMC1 and TMC2; reduces MET currents.
Causes deafness; disrupts interaction with TMC1 and TMC2; abolishes MET currents; abolishes localization of TMC1 and TMC2 to stereocilia.
Causes profound deafness. Does not disrupt localization in hair cell stereocilia. No obvious indications of vestibular dysfunction.
Disrupts interaction with TMC1. Disrupts mechanoelectrical transduction (MET) in hair cells.
Loss of N-terminal lipidation. Fails to localize to the photoreceptor outer segment.
Loss of catalytic activity. Slows down degradation of misfolded proteins from the ER.
Chondroitin sulfate N-acetylgalactosaminyltransferase 2
Important for FDH activity and activation by fatty acids
Sodium channel protein type 5 subunit alpha
Zinc finger SWIM domain-containing protein 1
Vitelline membrane outer layer protein 1 homolog
In Aey12; dominant negative mutation. Viable and fertile with a small eye phenotype. The lens is absent and only the lens envelope remains. The retina is misfolded and poorly differentiated. Heterozygotes show variable degrees of lens opacity and abnormal primary lens fiber elongation. Defects are apparent from embryonic stage 12.5 dpc onwards.
Pleckstrin homology domain-containing family S member 1
Receptor-type tyrosine-protein phosphatase U
Transmembrane protease serine 11G catalytic chain
Transmembrane protease serine 11G non-catalytic chain
Biorientation of chromosomes in cell division protein 1-like 1
Loss of interaction with RNF4; when associated with S-1702; R-1736 and V-1737.
Loss of interaction with RNF4; when associated with T-1629 and S-1702.
Loss of interaction with RNF4; when associated with T-1629; R-1736 and V-1737.
Reduces the inhibitory effect of the atypical PHD domain.
Ras-specific guanine nucleotide-releasing factor RalGPS2
Required for stimulation of nucleotide exchange by RALA
Abolishes glycosylation. Abolishes secretion; when associated with Q-229.
Abolishes glycosylation. Abolishes secretion; when associated with Q-281.
Abolishes secretion as a result of protein misfolding, protein is retained in the endoplasmic reticulum.
Enhances secretion and favors trimer formation.
Enhances secretion and reduces the formation of higher molecular weight oligomers.
No effect on secretion or protein folding.
Required for correct protein folding in the endoplasmic reticulum
22 X 12 AA approximate tandem repeats of Q-K-G-R-Q-D-Q-S-P-H-Q-G
48 X 12 AA approximate tandem repeats of Q-[KT]-[GD]-[RS]-Q-[DG]-Q-S-[PS]-H-X-G
Calcium/calmodulin-dependent protein kinase type 1
Abolishes deglutamylase activity; when associated with Q-806.
Abolishes deglutamylase activity; when associated with S-803.
Pleckstrin homology-like domain family B member 1
Serine/threonine-protein phosphatase 6 regulatory subunit 1
In kika; mice develop autoimmunity with splenomegaly, multiple autoantibodies, and increased total and activated B cells, germinal centers, plasma cells and memory CD4+ T cells.
Leucine-rich repeat-containing protein 30
Phosphoserine; by CaMK2, PKA, PKC and ROCK2
Phosphoserine; by PKA and PKC; alternate
Important for binding substrate proteins
Beta-like import receptor binding (BIB) domain
Large ribosomal subunit protein uL23 N-terminal
SH3 domain-containing YSC84-like protein 1
7-methylguanosine phosphate-specific 5'-nucleotidase
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Disintegrin and metalloproteinase domain-containing protein 23
Ankyrin repeat domain-containing protein 63
Thioredoxin-related transmembrane protein 2
GRIP and coiled-coil domain-containing protein 1
Lethal giant larvae (Lgl)-like C-terminal
Lethal(2) giant larvae protein homolog 1
Leucine-rich repeat and IQ domain-containing protein 1
Cation-transporting P-type ATPase C-terminal
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Ubiquinol-cytochrome c reductase complex assembly factor 4
Abolishes sumoylation. Abolishes sumoylation; when associated with R-868 and R-872.
No change in sumoylation. Abolishes sumoylation; when associated with R-868 and R-882.
No change in sumoylation. Abolishes sumoylation; when associated with R-872 and R-882.
NAD(P)H pyrophosphatase NUDT13, mitochondrial
Acyl-coenzyme A thioesterase 2, mitochondrial
Ubiquitin-conjugating enzyme E2 variant 1
Ubiquitin carboxyl-terminal hydrolase 40
CBY1-interacting BAR domain-containing protein 1
N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1
V-set and immunoglobulin domain-containing protein 8
Greatly reduces inhibition of calcineurin phosphatase activity.
Increases basal catalytic activity. Does not affect interaction with PPP3R1/calreticulin B and calmodulin.
Increases catalytic activity independently of calmodulin. Does not affect interaction with PPP3R1/calreticulin B and calmodulin.
Increases catalytic activity independently of calmodulin. Loss of interaction with calmodulin. Does not affect interaction with PPP3R1/calreticulin B.
Interaction with PxIxIF motif in substrate
Interaction with PxVP motif in substrate
Loss of catalytic activity. Loss of interaction with PPP3R1/calreticulin B and calmodulin.
Protein phosphatase 3 catalytic subunit alpha
Epithelial splicing regulatory protein 1
In isoform 2, isoform 3, isoform 4 and isoform 5.
TERF1-interacting nuclear factor 2 N-terminal
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Strongly impairs function, tyrosine phosphorylation, subcellular location and interaction with DOK1; when associated with F-1021.
Strongly impairs function, tyrosine phosphorylation, subcellular location and interaction with DOK1; when associated with F-918.
ER membrane protein complex subunit 7 beta-sandwich
Deficient in binding to RAN-GTP and in GTP release activity.
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Coiled-coil domain-containing protein 57
Does not affect association with Fc receptor gamma chain.
Fails to interact with DLG1. No effect on cell surface localization.
No effect on potentiation of WNT7A signaling.
HUWE1-associated protein modifying stress responses
Eukaryotic translation initiation factor 1b
Potassium voltage-gated channel subfamily H member 5
G protein-activated inward rectifier potassium channel 3
Eukaryotic peptide chain release factor subunit 1
NIKS motif; plays an important role in translational termination
Interaction with TAX1BP1 and CALCOCO2/NDP52
Zinc finger and BTB domain-containing protein 22
65% decrease in cross-linking efficiency; when associated with L-35.
65% decrease in cross-linking efficiency; when associated with L-36.
99% decrease in cross-linking efficiency; when associated with A-35 and A-36.
99% decrease in cross-linking efficiency; when associated with A-35 and A-48.
99% decrease in cross-linking efficiency; when associated with A-36 and A-48.
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)
V region (type III connecting segment, IIICS)
Causes a split-hand/split-foot phenotype in knockin mice. Gain-of-function mutant that cases a constitutive ribotoxic stress response (RSR).
Mitogen-activated protein kinase kinase kinase 20
ATP-sensitive inward rectifier potassium channel 11
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Abolishes binding to HRAS and KRAS; does not affect kinase activity; displays defective development of the lymphatic vasculature, resulting in perinatal appearance of chylous ascites and is highly resistant to endogenous Ras oncogene-induced tumorigenesis; when associated with A-227.
Abolishes binding to HRAS and KRAS; does not affect kinase activity; displays defective development of the lymphatic vasculature, resulting in perinatal appearance of chylous ascites and is highly resistant to endogenous Ras oncogene-induced tumorigenesis; when associated with D-208.
Loss of kinase activity; displays early embryonic lethality at 10-11 dpc and severe defects in angiogenic sprouting and vascular remodeling. Heterozygous mice yield adult mice with markedly impaired insulin signaling and reduced activation of effector pathways such as Akt/PKB.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Fails to inhibit LPS-induced cytokine production.
May mediate the interaction with C17orf75, FAM91A1 and WDR11
May mediate the interaction with FKBP15 and WASHC2; required for endosome to Golgi trafficking
Important for transcriptional activation
2-oxoglutarate and iron-dependent oxygenase JMJD4
Part of a helix bundle domain, formed by helices from N-terminal and C-terminal regions
F-box-like/WD repeat-containing protein TBL1XR1
Significantly decreases interaction with MECP2.
Substantially reduces interaction with MECP2.
Weakly decreases interaction with MECP2.
RalBP1-associated Eps domain-containing protein 2
N-terminal EF-hand calcium-binding protein 3
Armadillo-like helical domain-containing protein 3
Fibronectin type III domain-containing protein 8
Coiled-coil domain-containing protein 12
Adenomatous polyposis coli N-terminal dimerisation
Adenomatous polyposis coli protein basic
Failure to localize to primary cilia. Loss of cholesterol-induced activity.
Loss of activity and cilium localization.
Loss of cholesterol binding and reduced SHH-induced activation. No effect on basal signaling.
Loss of sterol binding and reduced response to SHH.
Reduced protein levels, reduced activity and loss of localization to cilia.
Remains responsive to SHH and 20S-hydroxycholesterol. Reduced basal signaling.
Methylmalonyl-CoA epimerase, mitochondrial
tRNA:m(4)X modification enzyme TRM13 homolog
Does not affect homo-, nor heterooligomerization with C1QL1, C1QL2 and C1QL3; when associated with A-28. Increased secretion; when associated with A-28. Does not impair inhibition of adipocyte differentiation; when associated with A-28.
Does not affect homo-, nor heterooligomerization with C1QL1, C1QL2 and C1QL3; when associated with A-32. Increased secretion; when associated with A-32. Does not impair inhibition of adipocyte differentiation; when associated with A-32.
Interaction with IGF2R cytoplasmic domain
Vacuolar protein sorting-associated protein 35
Platelet-derived growth factor D, latent form
Platelet-derived growth factor D, receptor-binding form
Mesoderm induction early response protein 3
In mouse mutant radical; reduced circulating B cells.
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Leads to enhanced neuronal differentiation of stem cells; when associated with E-96.
Leads to enhanced neuronal differentiation of stem cells; when associated with N-98.
In isoform 2, isoform 3, isoform 5, isoform 7 and isoform 9.
In isoform 3, isoform 4, isoform 7 and isoform 8.
In isoform 5, isoform 6, isoform 7, isoform 8, isoform 9 and isoform 10.
Reduced recovery of intracellular sodium-dependent pH.
Sodium-driven chloride bicarbonate exchanger
Zinc finger ZZ-type and EF-hand domain-containing protein 1
Peptidyl-prolyl cis-trans isomerase FKBP8
Abolishes ubiquitination and antibacterial activity and results in diffuse perinuclear distribution.
Macrophage-expressed gene 1 protein, processed form
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Large ribosomal subunit protein uL30-like 1
Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
Necessary for interaction with PNN and exon-skipping
Necessary for interaction with SRP54, nuclear localization and exon-skipping
Necessary for interaction with TRA2B, nuclear localization and exon-skipping
Necessary for interaction with the cleaved p110 isoform of CDC2L1
Necessary for interactions with UPF2 and UPF3B and UPF2-dependent NMD
RNA-binding protein with serine-rich domain 1
Killer cell lectin-like receptor subfamily B member 1
Large ribosomal subunit protein uL10-like insertion
Cell division cycle protein 20 homolog B
Acyl-coenzyme A amino acid N-acyltransferase 2
Interleukin-1 receptor antagonist protein
Shows less organization of the circumferential actin-filament network compared to controls.
Loss of antimicrobial activity; when associated with A-92.
Loss of antimicrobial activity; when associated with A-96.
Reactive bond for chymotrypsin, trypsin and elastase
Lysosomal-associated transmembrane protein 4B
PxLPxI/L motif; mediates interaction with ANKRA2 and 14-3-3 proteins
Methionine-R-sulfoxide reductase B2, mitochondrial
Heterogeneous nuclear ribonucleoproteins C1/C2
Echinoderm microtubule-associated protein-like 1
Myeloid-associated differentiation marker-like protein 2
Ubiquitin carboxyl-terminal hydrolase 22
Cysteine-rich hydrophobic domain-containing protein 1
Cytochrome c oxidase subunit 7B, mitochondrial
Loss of enzyme activity. No effect on ligand binding.
Reduces enzyme activity by about half. Reduces enzyme activity tenfold; when associated with A-45 and A-81.
Reduces enzyme activity by about half. Reduces enzyme activity tenfold; when associated with A-67 and A-81.
Slightly reduced enzyme activity. half. Reduces enzyme activity tenfold; when associated with A-45 and A-67.
Affects N-glycosylation. Abolishes Nglycosylation; when associated with Q-251 and Q-310. Does not affect cell membrane localization. Abolishes L-glutamine transport activity; when associated with Q-251.
Affects N-glycosylation. Abolishes Nglycosylation; when associated with Q-257 and Q-310. Does not affect cell membrane localization. Abolishes L-glutamine transport activity; when associated with Q-257.
Does not affect N-glycosylation. Abolishes Nglycosylation; when associated with Q-251 and Q-257. Does not affect cell membrane localization.
Does not affect N-glycosylation. Does not affect cell membrane localization.
Sodium-coupled neutral amino acid symporter 1
Essential for determining substrate specificity
Serine/threonine-protein phosphatase 2A activator
Mediates interaction with CDHR2, CDHR5 and USH1C
Golgi-associated PDZ and coiled-coil motif-containing protein
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Required for CTNNB1 accumulation and TCF transcription factor activity
Required for Wnt-activated receptor activity
Sodium/potassium-transporting ATPase subunit alpha-1
Interferon-induced protein with tetratricopeptide repeats 2
Pre-B-cell leukemia transcription factor 4
Xylosyl- and glucuronyltransferase LARGE1
Abolishes homodimerization; when associated with 515-A-A-516.
Abolishes homodimerization; when associated with A-519.
Important for homodimerization and oligomerization
Mediates retention in the endoplasmic reticulum
Mitochondrial inner membrane protein OXA1L
Tumor necrosis factor receptor superfamily member 1B
Required for interaction with F-actin-capping protein subunit alpha (CAPZA1 or CAPZA2 or CAPZA3)
Sufficient for interaction with WASHC3, WASHC4 and WASHC5; required for interaction with WASHC1
Strongly reduces transactivation and transforming capability.
Tumor necrosis factor receptor superfamily member 21
1-acylglycerol-3-phosphate O-acyltransferase Pnpla3
Increases 1-acylglycerol-3-phosphate O-acyltransferase activity 2-fold; promotes hepatic lipid synthesis.
7 X 5 AA tandem repeats of [LM]-E-[QR]-[EQ]-[QR]
No change in subcellular location nor colocalization with vinculin at focal adhesions nor with N-WASP at the leading edge. Loss of cell mobility function; when associated with A-637.
No change in subcellular location nor colocalization with vinculin at focal adhesions nor with N-WASP at the leading edge. No loss of cell mobility function. when associated with A-255.
No change in subcellular location nor colocalization with vinculin at focal adhesions nor with N-WASP at the leading edge. No loss of cell mobility function. when associated with D-255.
No change in subcellular location nor colocalization with vinculin at focal adhesions nor with N-WASP at the leading edge. No loss of cell mobility function; when associated with D-637.
Leucine-rich repeat and fibronectin type-III domain-containing protein 2
2-fold decrease in substrate affinity and 96% reduction in O-GlcNAcase activity. Regains appreciable level of catalytic efficiency in the acidic pH range. 40% recovery of activity in the presence of sodium azide.
2-fold increase in substrate affinity and 77% reduction in O-GlcNAcase activity. Regains appreciable level of catalytic efficiency in the acidic pH range. No recovery of activity in the presence of sodium azide.
3-fold increase in substrate affinity and 90% reduction in O-GlcNAcase activity. Regains appreciable level of catalytic efficiency in the acidic pH range. 70% recovery of activity in the presence of sodium azide.
No change in substrate affinity but 60% reduction in O-GlcNAcase activity.
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
Necessary for RNA-binding, interaction with MAGOH and localization in nucleus speckles
Necessary for localization in cytoplasmic stress granules
Advanced glycosylation end product-specific receptor
PHD and RING finger domain-containing protein 1
Leucine-rich repeat-containing protein 39
Uracil phosphoribosyltransferase homolog
Leucine-rich repeat transmembrane neuronal protein 4
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Ankyrin repeat domain-containing protein 33B
Transcription termination factor 1a, mitochondrial
Almost abolishes interaction with SHANK3.
In isoform 2, isoform 3, isoform 5 and isoform 6.
Sorbin and SH3 domain-containing protein 2
Mitogen-activated protein kinase kinase kinase 14
Asymmetric dimethylarginine; by autocatalysis
DNA-directed RNA polymerase III subunit RPC5
DNA-directed RNA polymerase III subunit RPC5 C-terminal
In strain: 129/SvEv; requires 2 nucleotide substitutions.
No change of phosphorylation implicated in interaction with PTPN6 and PTPN11. Severe reduction of phosphorylation; when associated with F-245 and/or F-274.
No change of phosphorylation implicated in interaction with PTPN6 and PTPN11. Severe reduction of phosphorylation; when associated with F-245 and/or F-299.
No change of phosphorylation implicated in interaction with PTPN6 and PTPN11. Severe reduction of phosphorylation; when associated with F-274 and/or F-299.
N-acetylvaline; in RNA-binding motif protein, X chromosome, N-terminally processed
RNA-binding motif protein, X chromosome, N-terminally processed
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha
Diphosphoinositol polyphosphate phosphohydrolase 3-beta
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
Tumor necrosis factor alpha-induced protein 8
10-fold loss in affinity to sialic acid.
Promotes mono and/or diubiquitination and nuclear exclusion. Reduces phosphorylation at S-345.
HIG1 domain family member 1A, mitochondrial
Uncharacterized protein KIAA0825 homolog
Selection and upkeep of intraepithelial T-cells protein 4
Leucine-rich repeat and death domain-containing protein 1
Interferon alpha-inducible protein 27-like protein 2B
Pleckstrin homology domain-containing family A member 6
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Required for activation by RHOA, RHOB, GNA12, GNA13 and G-beta gamma
V-type immunoglobulin domain-containing suppressor of T-cell activation
Greatly reduced levels of PIAS3-mediated sumoylation. Completely abolishes sumoylation; when associated with R-315 and R-322.
Little change in sumoylation. Completely abolishes sumoylation; when associated with R-178 and R-315.
Little change in sumoylation. Completely abolishes sumoylation; when associated with R-178 and R-322.
Loss of mitochondrial localization. Loss of cannabinoid-induced reduction of respiration, mitochondrial mobility, synaptic transmission and memory formation. No effect on MAPK/ERK signaling, nor on G protein activation.
Myelin transcription factor 1-like protein
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
PC-esterase domain-containing protein 1A
Loss of affinity for GTP and loss of interaction with RUNDC3A.
Loss of association with the recycling endosome membranes and loss of TNIK activation; when associated with C-176.
Loss of association with the recycling endosome membranes and loss of TNIK activation; when associated with C-177.
Serine/threonine-protein phosphatase 4 regulatory subunit 1
Sterile alpha motif domain-containing protein 12
Ewing's tumor-associated antigen 1 homolog
Abolishes interaction with CTNNB1. No effect on nuclear localization.
Progestin and adipoQ receptor family member 3
Required for endocytosis and down-regulation
Mediates interaction with CDKN2A/isoform tumor suppressor ARF
Mediates interaction with human herpesvirus 8 protein ORF16
Basic leucine zipper transcriptional factor ATF-like 3
Rho guanine nucleotide exchange factor 1
Clathrin heavy chain linker domain-containing protein 1
Small glutamine-rich tetratricopeptide repeat-containing protein beta
Eukaryotic translation initiation factor 3 subunit G
Tumor necrosis factor receptor superfamily member 9
Abolished E3 ubiquitin-protein activity and ability to inhibit type I interferon IFN-beta production.
Abolished E3 ubiquitin-protein activity and ability to ubiquitinate TICAM1. Abolished E3 SUMO-protein activity and ability to sumoylate CGAS.
SEC14 domain and spectrin repeat-containing protein 1
Loss of kinase activity and ability to activate JNK family. Inhibits the ability of CLNK to up-regulate CD3-triggered activation of the IL2 promoter.
Mitogen-activated protein kinase kinase kinase kinase 1
Calcium/calmodulin-dependent protein kinase type II subunit delta
Glutamate receptor ionotropic, kainate 5
6-phosphogluconate dehydrogenase, decarboxylating
DNA damage-regulated autophagy modulator protein 2
Corresponds to C-356 variant associated with SPGF16 in human. Impairs nuclear inner membrane location and decreases interaction with DNAJB13.
Corresponds to I-348 variant associated with SPGF16 in human. Impairs nuclear inner membrane location and increases interaction with DNAJB13.
Corresponds to M-261 variant associated with SPGF16 in human. Decreases protein solubility, impairs nuclear inner membrane location and decreases interaction with DNAJB13.
Corresponds to M-275 variant associated with SPGF16 in human. Impairs nuclear inner membrane location and decreases interaction with DNAJB13.
Corresponds to R-114 variant associated with SPGF16 in human. Impairs nuclear inner membrane location, expressed in the cytosol with some protein aggregation near the nuclear envelope.
Corresponds to variant K-162 associated with SPGF16 in human. Increases interaction with DNAJB13. Impairs nuclear inner membrane location, expressed in the cytosol with some protein aggregation near the nuclear envelope.
BTB/POZ domain-containing protein KCTD12
Abolishes lowering of temperature threshold for activation in response to reactive oxygen species.
Transient receptor potential cation channel subfamily M member 2
Cilia- and flagella-associated protein 57
Binds urokinase plasminogen activator surface receptor
Urokinase-type plasminogen activator chain B
Urokinase-type plasminogen activator long chain A
Urokinase-type plasminogen activator short chain A
Cysteine-rich secretory protein LCCL domain-containing 1
Ectonucleoside triphosphate diphosphohydrolase 3
ADAMTS/ADAMTS-like cysteine-rich domain-containing protein
Does not affect ability to promote ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis).
Ferritin heavy chain, N-terminally processed
N-acetylthreonine; in Ferritin heavy chain, N-terminally processed
Eukaryotic translation initiation factor 4H
Golgi-associated olfactory signaling regulator
Membrane-spanning 4-domains subfamily A member 10
Protein mono-ADP-ribosyltransferase TIPARP
Coiled-coil domain-containing protein 150
Nucleolar and spindle-associated protein 1
Abolishes binding of FBXL3 and SKP1. Strongly decreases CRY2 degradation.
Decreases FBXL3 binding. Strongly decreases CRY2 degradation.
Impairs protein folding. Abolishes binding of BMAL1, PER1 and FBXL3. Strongly reduces SKP1 binding.
Inhibits interaction with PER2. Does not suppress its nuclear localization. Inhibits its repression activity on CLOCK|NPAS2-BMAL1-driven transcription.
Loss of ability to inhibit CLOCK-BMAL1-mediated transcriptional activity. No loss of ability to inhibit NR1I2 transcriptional activity.
Reduced in vitro MAPK-catalyzed phosphorylation. No effect on inhibition of CLOCK-BMAL1-mediated transcriptional activity. Very little in vitro MAPK-catalyzed phosphorylation; when associated with A-265. Shorter circadian rhythm; when associated with A-553.
Reduced in vitro MAPK-catalyzed phosphorylation. No effect on inhibition of CLOCK-BMAL1-mediated transcriptional activity. Very little in vitro MAPK-catalyzed phosphorylation; when associated with A-557.
Reduced inhibition of CLOCK-BMAL1-mediated transcriptional activity. No effect on nuclear localization nor on protein stability.
Reduced interaction with NR1I2 and NR1I3. Significant decrease in interaction with NR1I2 and NR1I3; when associated with E-394 and K-397.
Reduced interaction with NR1I2 and NR1I3. Significant decrease in interaction with NR1I2 and NR1I3; when associated with E-394 and M-396.
Reduced interaction with NR1I2 and NR1I3. Significant decrease in interaction with NR1I2 and NR1I3; when associated with M-396 and K-397.
Required for inhibition of CLOCK-BMAL1-mediated transcription
Shorter circadian rhythm; when associated with A-557.
Essential for binding to NHERF1 PDZ domain
Short transient receptor potential channel 5
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Involved in proton transfer during cleavage
Abolished ability to activate SLC12A2/NKCC1.
Impaired phosphorylation by WNK4 and activation. Abolished ability to activate SLC12A2/NKCC1. Knockin mice are unable to activate SLC12A3/NCC.
Increased kinase activity and autophosphorylation.
Loss of kinase activity but no loss of interaction with RELT.
STE20/SPS1-related proline-alanine-rich protein kinase
U4/U6 small nuclear ribonucleoprotein Prp3
Ankyrin repeat domain-containing protein SOWAHD
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
Signal recognition particle 14 kDa protein
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
4 X 15 AA tandem repeats of A-A-A-A-A-P-E-A-A-A-S-[PL]-E-S-S
Transmembrane gamma-carboxyglutamic acid protein 3
Essential for GTPase activation (GAP) activity
Necessary for binding to phosphoinositide-3-P; not sufficient for targeting to endosomes
Necessary for homooligomerization and targeting to endosomes
Coiled-coil domain-containing protein 184
Increased targeting to the endosomal/lysosomal compartment and reduced myotube formation.
Inefficient targeting to the endosomal/lysosomal compartment and enhanced myotube formation.
Required for endosomal and lysosomal localization
Necessary and sufficient for interaction with PCGF1
Drastic decrease in GRB2-binding, but no effect on VAV-binding; when associated with A-552. Partial loss of enhancement of LPS-induced TNF production; when associated with A-552.
Drastic decrease in GRB2-binding, but no effect on VAV-binding; when associated with A-555. Partial loss of enhancement of LPS-induced TNF production; when associated with A-555.
Loss of phosphorylation. Loss of LYN-binding. Slight decrease in GRB2-binding. No effect on VAV-binding. Partial loss of enhancement of LPS-induced TNF production.
Mothers against decapentaplegic homolog 3
Phosphothreonine; by CDK2, CDK4 and MAPK
Required for interaction with DNA and JUN and for functional cooperation with JUN
ATPase family AAA domain-containing protein 5
Probable ATP-dependent RNA helicase DDX17
Reduces phosphorylation by PIM2 by 60%, and decreases the transcriptional activity of MYC.
Dihydropyrimidine dehydrogenase [NADP(+)]
Necessary for interaction with SS18L1/CREST
RNA-binding region which is sufficient for binding to lncRNA Evf2
Required for binding to 'Lys-15'-acetylated histone 3
Carcinoembryonic antigen-related cell adhesion molecule 10
5-methylcytosine rRNA methyltransferase NSUN4
Mitochondrial import inner membrane translocase subunit Tim17-A
Ral guanine nucleotide dissociation stimulator-like 1
Abolished localization to lipid droplets.
Does not affect localization to lipid droplets but prevents lipid droplet fusion.
Does not affect localization to lipid droplets or ability to mediate lipid droplet fusion.
Sustantial reduction in nuclear localization and loss of XDH induction; when associated with A-23.
Sustantial reduction in nuclear localization and loss of XDH induction; when associated with A-24.
Aldehyde dehydrogenase family 3 member A2
Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner
Changes the function in transcription regulation.
Changes the specificity for binding motifs in promoters. Recognizes the PITX1 consensus DNA-binding sites and triggers the expression of a gene pattern similar to PITX1.
Interaction with DPF motifs-containing proteins
Necessary and sufficient to mediate interaction with CANX
SH3-containing GRB2-like protein 3-interacting protein 1
Sodium-dependent noradrenaline transporter
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Significant hearing impairment, associated with loss or degeneration of cochlear outer hair cells.
Gamma-aminobutyric acid receptor subunit gamma-3
Leucine-rich repeat-containing G-protein coupled receptor 5
Does not affect polynucleotide adenylyltransferase activity. Increases cell apoptosis.
Increases polynucleotide adenylyltransferase activity.
Loss of polynucleotide adenylyltransferase activity.
Significantly increases polynucleotide adenylyltransferase activity.
Significantly reduces polynucleotide adenylyltransferase activity.
DNA mismatch repair proteins mutS family
Thioredoxin reductase-like selenoprotein T
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Peptidyl-prolyl cis-trans isomerase FKBP10
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Phosphoserine; by IKKA, IKKB, IKKE and TBK1
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Translation initiation factor IF-3, mitochondrial
Ankyrin repeat domain-containing protein 13D
Important for AKT1 activation and IL8 production
No effect on chiting-binding. No restoration of chitinase activity.
Ubiquinol-cytochrome c reductase complex assembly factor 6
Dehydrogenase/reductase SDR family member 1
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Necessary for interaction with USP7 and ATRX
Phosphopantetheine adenylyltransferase activity abolished.
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
Protein phosphatase 1 regulatory subunit 1A
RNA-binding protein with multiple splicing
Required for interaction with RNA-binding proteins DDX5, HNRNPH2 and SRSF1 and with mRNAs
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Required for activation of histone H4 transcription and contributes to DNA-binding
Interaction with POLR2A; SFRS1; SFRS9 and SFRS10
Lactosylceramide alpha-2,3-sialyltransferase
HCH Motif; seals regulatory zinc-binding pocket
Tumor necrosis factor receptor superfamily member 10B
Mimics the charge change that accompanies citrullination, resulting in impaired nucleosome-binding.
Retains the positive charge, resulting in slightly decreased nucleosome-binding.
Disrupts interaction with SH2D1B, abolishes NK cell activation in presence of SH2D1B, no effect on NK cell inhibition in absence of SH2D1B.
Interaction with FYN when phosphorylated at Tyr-282
No effect on interaction with SH2D1, no effect on NK cell activation in presence of SH2D1B, no effect on NK cell inhibition in absence of SH2D1B.
No effect on interaction with SH2D1B, increases NK cell activation in presence of SH2D1B, abolishes NK cell inhibition in absence of SH2D1B.
Does not affect guanylate cyclase activity; when associated with S-458.
Does not affect guanylate cyclase activity; when associated with S-465.
Gives susceptibility to xenotropic murine leukemia retroviruses infection.
Important for inositol polyphosphate binding
Changed cilium assembly. Adult animals develop myxomatous mitral valves and functional mitral valve prolapse.
Loss of phosphorylation by GSK3-beta. Decreased interaction with GDI2.
Loss of phosphorylation by PLK1. Increased interaction with PCM1.
Mediates interaction with GDI2 and RAB8A
Mediates interaction with GLI3 and localization to the cilium basal body
Phosphorylation mimicking mutant. Increased interaction with GDI2.
Transcription initiation factor TFIID subunit 9B
Embryos have congenital heart defects with transposition of the great artery, 61% exhibiting situs inversus or heterotaxy and 39% exhibiting situs solitus. This mutation corresponds to the pathological variant 'T-226' identified in humans.
Koli mutant, animals exhibit visceral heterotaxy, with heart defects commonly associated with heterotaxy.
Miri mutant, animals exhibit visceral heterotaxy, with heart defects commonly associated with heterotaxy.
Coiled-coil domain-containing protein 158
Loss of localization to the cell membrane.
Mitochondrial import inner membrane translocase subunit Tim8 B
Glutaredoxin-related protein 5, mitochondrial
Inhibits Schwann cell peripheral myelination; when associated with A-831; A-848 and A-1327.
Inhibits Schwann cell peripheral myelination; when associated with A-831; A-848 and A-881.
Inhibits Schwann cell peripheral myelination; when associated with A-831; A-881 and A-1327.
Inhibits Schwann cell peripheral myelination; when associated with A-848; A-881 and A-1327.
Strongly reduces phosphorylation by PRKCZ and abolishes interaction with PKRCI.
Impairs RHOA activation; when associated with 566-A-A-567.
Impairs RHOA activation; when associated with A-562.
No effect on RHOA activation; when associated with 547-A-A-548.
No effect on RHOA activation; when associated with 554-A-A-555.
Rho guanine nucleotide exchange factor 15
Glutaredoxin-like protein C5orf63 homolog
Abolishes interaction with polyubiquitinated IRAK1.
Abolishes ubiquitin binding; loss of inhibitory activity on NF-kappa-B activation.
Abolishes ubiquitin binding; loss of inhibitory activity on TNF-induced NF-kappa-B activation; no effect on interaction with TNFAIP3.
Loss of inhibitory activity on TNF-induced NF-kappa-B activation; no effect on interaction with TNFAIP3.
Required for inhibitory activity of TNF-induced NF-kappa-B activation
Ribosomal RNA-processing protein 7 homolog A
26S proteasome non-ATPase regulatory subunit 3
Long-chain fatty acid transport protein 6
Peptidoglycan recognition protein family
Important for ABL1-mediated Tyr-718 phosphorylation
Strong decrease in catalytic activity; when associated with A-707.
Strong decrease in catalytic activity; when associated with A-711.
ATP synthase subunit C lysine N-methyltransferase
von Willebrand factor D and EGF domain-containing protein
4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)
Necessary for poly U RNA-binding and snRNA export
Partially reduces its import in the nucleus.
Phosphorylated adapter RNA export protein
Phosphorylated adapter RNA export protein RNA-binding
Reduces U snRNA export. Strongly abolishes the U snRNA export complex formation. Does not abolish the pre-complex formation.
Strongly reduces its import in the nucleus. Abolishes its import in the nucleus, does not change its export to the cytoplasm and the export of U snRNA complex; when associated with 190-AA-191.
Strongly reduces its import in the nucleus. Abolishes its import in the nucleus, does not change its export to the cytoplasm and the export of the U snRNA complex; when associated with 71-ARAA-74.
Transient receptor potential cation channel subfamily V member 2
Interaction with ANLN and localization to the midbody
(Lyso)-N-acylphosphatidylethanolamine lipase
Interaction with Complement C3 beta chain
Abolishes proteolytic cleavage of the propeptide.
Processed zona pellucida sperm-binding protein 2
Abolishes protease activity. No inhibition of BMP4-mediated signaling.
Abolishes active hydrolase probe binding in serine hydrolase assays.
Reduced levels of autophosphorylation. Abolishes interaction with GRB2 and GRB7. Abolishes phosphorylation of GRB7 and PIK3R1.
Ras association domain-containing protein 6
Abolishes interaction with ZAP70, but does not affect interaction with SLA.
Abolishes myristoylation and palmitoylation.
Abolishes palmitoylation and plasma membrane association; when associated with A-3.
Abolishes palmitoylation and plasma membrane association; when associated with A-6.
Abolishes palmitoylation and plasma membrane association; when associated with S-3.
Abolishes palmitoylation and plasma membrane association; when associated with S-6. Abolishes plasma membrane association.
Cilia- and flagella-associated protein 58
Signal peptide, CUB and EGF-like domain-containing protein 1
Endosome/lysosome-associated apoptosis and autophagy regulator family member 2
Glycolipid transfer protein domain-containing protein 2
Zinc finger CCCH-type antiviral protein 1
Prostate tumor-overexpressed gene 1 protein homolog
Impairs ATP-binding inducing a 80% decrease in enzyme activity.
Cytochrome c oxidase assembly factor 6 homolog
Ankyrin repeat domain-containing protein 17
Phosphatidic acid phosphatase type 2/haloperoxidase
Shows no significant DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to approximately 34% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells.
Shows very weak DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to 43% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells.
Protein phosphatase 1 regulatory subunit 29
Abolishes inositol 1,4,5-triphosphate binding.
Complete loss of channel activity. Significant decrease of interaction with ERP44.
Decreases interaction with AHCYL1; when associated with A-1588.
Decreases interaction with AHCYL1; when associated with A-1755.
In isoform 2, isoform 4, isoform 6 and isoform 8.
In isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8.
In isoform 5, isoform 6, isoform 7 and isoform 8.
Increases interaction with AHCYL1; when associated with A-1588.
Increases interaction with AHCYL1; when associated with A-1755.
Inositol 1,4,5-trisphosphate receptor type 1
No effect on channel activity. Significant decrease of interaction with ERP44. Complete loss of channel inhibition by ERP44.
Strongly reduced palmitoylation; when associated with A-56 and A-2215.
Strongly reduced palmitoylation; when associated with A-56 and A-849.
Strongly reduced palmitoylation; when associated with A-849 and A-2215.
ADP-ribosylation factor-like protein 6-interacting protein 4
Loss of MALT1-dependent cleavage and degradation in T-cells.
Loss of RNase activity and no loss of protein deubiquitination; when associated with A-226.
Loss of RNase activity, no loss of protein deubiquitination and ability to inhibit stress granule (SG) formation under stress; when associated with A-226.
Loss of RNase activity. Loss of mRNAs and miRNAs degradation. Loss of protein deubiquitination and suppression of inhibition on JNK and NF-kappa-B signaling pathway activation. Inhibits induction of angiogenesis and macrophage M2 polarization. Mislocalized in stress granule (SG). Loss of the ability to inhibit SG formation under stress. Does not inhibit binding to IL6 mRNA. Increases ICOS surface expression.
Loss of inhibition on JNK and NF-kappa-B signaling pathway activation; when associated with A-278.
Loss of inhibition on JNK and NF-kappa-B signaling pathway activation; when associated with A-279.
Loss of protein deubiquitination and suppression of inhibition on JNK and NF-kappa-B signaling pathway activation. Loss of the ability to inhibit stress granule (SG) formation. No loss of RNase activity. No effect on ICOS surface expression.
Loss of protein deubiquitination and suppression of inhibition on JNK and NF-kappa-B signaling pathway activations. No loss of RNase activity.
Reduces MALT1-dependent cleavage and degradation in T-cells.
Reduces its phosphorylation status, does not interact with IKBKB/IKKB and BTRC, inhibits IL6 mRNA instability and IKK-mediated degradation of ZC3H12A; when associated with A-435.
Reduces its phosphorylation status, does not interact with IKBKB/IKKB and BTRC, inhibits IL6 mRNA instability and IKK-mediated degradation of ZC3H12A; when associated with A-439.
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Drastic decrease in basal cAMP production.
Drastic reduction in basal cAMP production.
Small reduction in basal cAMP production.
Ubiquitin-fold modifier-conjugating enzyme 1
Structural maintenance of chromosomes protein 1A
Secretory carrier-associated membrane protein 3
Does not act as a substrate-trapping mutant.
Glutamate-rich WD repeat-containing protein 1
Histone-binding protein RBBP4 N-terminal
Loss of catalytic activity. No effect on RNF11-binding. No effect on KLF2 ubiquitination. Abolishes ubiquitination of KLF5.
NEDD4-like E3 ubiquitin-protein ligase WWP1
Required for ubiquitin-thioester formation
NADPH:adrenodoxin oxidoreductase, mitochondrial
Coiled-coil domain-containing protein 66
Forms homodimers processed at L-112 that seem more stable than the wild-type.
Reduced hippocampal volume, dendritic complexity and context-dependent memory. Decreased density of dendritic mushroom spines and synapses. Impaired fear extinction. Increased anxiety-related behaviors.
Decreased MCM complex DNA helicase activity. Reduced ssDNA binding. No effect on MCM complex formation. No effect on MCM complex ATP binding and ATPase activity.
Results in unstable hexamers. Increased MCM complex DNA helicase activity.
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7
Uncharacterized membrane protein C3orf80 homolog
Probable ATP-dependent RNA helicase DDX31
Dual serine/threonine and tyrosine protein kinase
Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4
Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin; required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3
3-beta hydroxysteroid dehydrogenase/isomerase
Calcium release-activated calcium channel protein 1
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Cleavage; by MMP2, MMP3, MMP7, MMP9, MMP12
EGF-containing fibulin-like extracellular matrix protein 2
Knockin mutant mice are viable and survive into adulthood. Mice display abnormalities in multiple organ systems, including loose skin, bent forelimb, aortic aneurysm, tortuous artery, and pulmonary emphysema. In addition to elastic fiber abnormalities in the skin and large arteries, collagen fibrils are irregularly shaped, with many large fibrils in the dermis. Mice have large artery stiffness and systolic hypertension. Reduces protein secretion.
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Voltage-dependent calcium channel alpha-1 subunit IQ
Alpha-D-phosphohexomutase alpha/beta/alpha
Actin-related protein 2/3 complex subunit 3
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
Sufficient for RNA-binding and MSE-dependent splicing activity
Changes the stereoselectivity of the oxygenation reaction to produce (15S)-HPETE instead of (8S)-HPETE. Completely changes the stereoselectivity; when associated with D-603.
Changes the stereoselectivity of the oxygenation reaction to produce (15S)-HPETE instead of (8S)-HPETE. Completely changes the stereoselectivity; when associated with V-604.
Polyunsaturated fatty acid lipoxygenase ALOX8
Retains catalytic activity indicating it is not required for iron ligand-binding.
IQCJ-SCHIP1 readthrough transcript protein
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Apoptosis-associated speck-like protein containing a CARD
Does not significantly affect kinase activity.
In DN mutant; Loss of kinase activity; leading to disrupted Ras and Rap protein signaling, altered spine morphology and aberrant memory formation in mice.
Mimicks phosphorylation state, leading to increased activity.
Decreased sumoylation; when associated with E-361; E-573; E-664; E-935 and E-1013.
Decreased sumoylation; when associated with E-361; E-573; E-664; E-935 and E-961.
Decreased sumoylation; when associated with E-361; E-573; E-664; E-961 and E-1013.
Decreased sumoylation; when associated with E-361; E-573; E-935; E-961 and E-1013.
Decreased sumoylation; when associated with E-361; E-664; E-935; E-961 and E-1013.
Decreased sumoylation; when associated with E-573; E-664; E-935; E-961 and E-1013.
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
Abolishes sphingosine kinase activity. Decreases apoptosis induction. Abolishes sphingosine kinase activity. No effect on endoplasmic reticulum location increase upon serum starvation. Abolishes sphingosine kinase activity and decreases apoptosis induction; when associated with A-219.
Loss of nuclear location. Loss of DNA synthesis inhibition.
Required for binding to sulfatide and phosphoinositides and for membrane localization
Strongly decreases sphingosine kinase activity. Decreases apoptosis induction. No effect on endoplasmic reticulum location increase upon serum starvation. Abolishes sphingosine kinase activity and decreases apoptosis induction; when associated with E-213.
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
H/ACA ribonucleoprotein complex subunit 1
Baculoviral IAP repeat-containing protein 1b
Important for the stable binding to the membranes
Catechol O-methyltransferase domain-containing protein 1
G-patch domain and KOW motifs-containing protein
Loss of interferon-gamma induced phosphorylation.
Multidrug resistance-associated protein 1
Loss of plasmanylethanolamine desaturase activity. Does not affect endoplasmic reticulum membrane localization.
Strongly reduces plasmanylethanolamine desaturase activity. Does not affect endoplasmic reticulum membrane localization.
Strongly inhibits the recognition of non-methylated CpGs.
Preferentially expressed antigen in melanoma-like protein 1
21 X 10 AA approximate tandem repeats of [DA]-[DE]-[ED]-R-[PLIGFSV]-[RPS]-[RW]-[RL]-[GNIHT]-[DGLPTAM]
Eukaryotic translation initiation factor 3 subunit A
Peptidyl-prolyl cis-trans isomerase FKBP1B
Cyclic AMP-responsive element-binding protein 5
Mitochondrial coenzyme A transporter SLC25A42
PH-like; mediates interaction with TGFB1I1
Cerebral cavernous malformations 2 protein-like
Insulin-like growth factor-binding protein 3 receptor
Required for ubiquitin ligase activity and protection against ER stress-induced cell death
Conserved oligomeric Golgi complex subunit 4
E domain; essential for proper cell surface glycosylation
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
Loss of function; when associated with A-268; A-320; A-322; A-400 and A-454.
Loss of function; when associated with A-268; A-320; A-322; A-400 and A-456.
Loss of function; when associated with A-268; A-320; A-322; A-454 and A-456.
Loss of function; when associated with A-268; A-320; A-400; A-454 and A-456.
Loss of function; when associated with A-268; A-322; A-400; A-454 and A-456.
Loss of function; when associated with A-320; A-322; A-400; A-454 and A-456.
In isoform 2, isoform 4, isoform 6, isoform 8, isoform 10, isoform 12 and isoform 14.
In isoform 3, isoform 4, isoform 7, isoform 8 and isoform 16.
Protein phosphatase 1 regulatory subunit 14A
Mediator of RNA polymerase II transcription subunit 23
Insulin-like growth factor 1 receptor alpha chain
Insulin-like growth factor 1 receptor beta chain
Formyl peptide receptor-related sequence 6
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Potassium voltage-gated channel subfamily A member 6
POU domain, class 3, transcription factor 1
Required for interaction with beta- and gamma-catenins
Trafficking protein particle complex subunit 12
Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA2
Transforming acidic coiled-coil-containing protein C-terminal
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Nuclear receptor subfamily 5 group A member 2
MEF2-activating motif and SAP domain-containing transcriptional regulator
Uncharacterized protein KIAA1958 homolog
LHFPL tetraspan subfamily member 7 protein
BAH and coiled-coil domain-containing protein 1
Hairy/enhancer-of-split related with YRPW motif-like protein
Transcriptional repression and interaction with NCOR1 and SIN3A
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Methionine aminopeptidase 1D, mitochondrial
Important for interaction with CD80 and CD86
Nuclear factor of activated T-cells, cytoplasmic 4
Decreased microtubule severing activity.
Required for interaction with SSNA1 and microtubules
Required for interaction with microtubules
Required for interaction with microtubules and microtubule severing
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Retains genomic stability and cell cycle checkpoint correction and kinase activity towards downstream targets; when associated with A-1987. Retains genomic stability, cell cycle checkpoint correction and kinase activity on downstream targets; when associated with A-1899 and A-1987.
Retains genomic stability and cell cycle checkpoint correction and kinase activity towards downstream targets; when associated with A-367. Retains genomic stability, cell cycle checkpoint correction and kinase activity on downstream targets; when associated with A-367 and A-1987.
Retains genomic stability, cell cycle checkpoint correction and kinase activity on downstream targets; when associated with A-367 and A-1987.
Probable RNA polymerase II nuclear localization protein SLC7A6OS
Chloride intracellular channel protein 1
Required for insertion into the membrane
Loss of interaction with clathrin heavy chains; when associated with 187-AAAAA-191.
Loss of interaction with clathrin heavy chains; when associated with 212-AAA-214.
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
22 X 6 AA tandem repeats of W-[PQ]-X-P-X-X
Abolishes the interaction with many chromatin regulators but not that with KMT5B and KMT5C; when associated with A-746 and A-750.
Abolishes the interaction with many chromatin regulators but not that with KMT5B and KMT5C; when associated with A-746 and A-754.
Abolishes the interaction with many chromatin regulators but not that with KMT5B and KMT5C; when associated with A-750 and A-754.
Loss of exclusive nuclear localization and loss of growth inhibition, when transfected in Saos-2 cells. No effect on the interaction with SV40 large T antigen.
Loss of exclusive nuclear localization, no effect on the interaction with SV40 large T antigen, adenovirus E1a, nor E2F1. Decreased growth inhibition activity, when transfected in Saos-2 cells. Complete loss of nuclear localization, loss of growth inhibition, when transfected in Saos-2 cells and loss of interaction with SV40 large T antigen, adenovirus E1a and E2F1; when associated with 733-K--P-769.
Loss of exclusive nuclear localization. Complete loss of nuclear localization, loss of growth inhibition, when transfected in Saos-2 cells and loss of interaction with SV40 large T antigen, adenovirus E1a and E2F1; when associated with 866-N--Q-869.
Loss of exclusive nuclear localization. Decreased growth inhibition activity, when transfected in Saos-2 cells. No effect on the interaction with SV40 large T antigen, adenovirus E1a, nor E2F1.
Increases T2 import. Does not affect T3 import. Does not affect L-leucine and L-phenylalanine uptake.
Increases T2 import. Does not affect T3 import. Does not affect L-leucine and L-phenylalanine uptake. Increases the export of both L-leucine and L-phenylalanine.
Increases T2 import. Increases T3 and enables T4 import. Does not affect L-leucine and L-phenylalanine uptake.
Large neutral amino acids transporter small subunit 2
Loss of kinase activity. No effect on colocalization with microtubules.
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
Organic solute transporter subunit alpha
Vacuolar protein sorting-associated protein 53 homolog
Dehydrogenase/reductase SDR family member 11
Decreased interaction with AP4M1. Has no effect on interaction with GRIA1. Dominant negative mutant which alters AMPARs localization to the somatodendritic compartment.
Voltage-dependent calcium channel gamma-3 subunit
Nucleolar pre-ribosomal-associated protein 1
Nucleolar pre-ribosomal-associated protein 1 C-terminal
Nucleolar pre-ribosomal-associated protein 1 N-terminal
Hereditary hemochromatosis protein homolog
Leucine-rich repeats and immunoglobulin-like domains protein 3
Loss of tyrosine phosphorylations by CABLES1 and ABL1; decreased activity.
Essential for receptor binding and receptor activation
Serine hydroxymethyltransferase, cytosolic
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2
Sufficient for basal bodies localization
Eukaryotic translation initiation factor 3 subunit J-B
Promotes stable association with the 40S ribosome
Required for localization in the endoplasmic reticulum
Store-operated calcium entry regulator STIMATE
T-cell leukemia translocation-altered gene protein homolog
RanBP-type and C3HC4-type zinc finger-containing protein 1
Sphingomyelin synthase-related protein 1
Abolished phosphorylation by GSK3B, preventing ubiquitination by the SCF(FBXO3) complex.
Ras GTPase-activating protein-binding protein 1
Extracellular and involved in cell to cell contact
No loss of interaction with PDCD6IP. Loss of interaction with PDCD6IP; when associated with 4-A--A-5 and 47-A--A-48.
No loss of interaction with PDCD6IP. Loss of interaction with PDCD6IP; when associated with 4-A--A-5 and 51-A--A-52.
No loss of interaction with PDCD6IP. Loss of interaction with PDCD6IP; when associated with 46-A--A-47 and 50-A--A-51.
SH3 domain-binding glutamic acid-rich protein
Interaction with DNMT1, DNMT3A and DNMT3B
DNA-directed RNA polymerase II subunit RPB9
Loss of autophosphorylation and kinase activity.
Complete loss of phosphorylation by MAPKAPK2, partial loss of phosphorylation by PKA, no effect on phosphorylation by PKC and CaMK2.
No effect on phosphorylation by PKC, PKA, MAPKAPK2 and CaMK2.
Zinc finger CCHC domain-containing protein 17
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Serine/arginine repetitive matrix protein 4
Serine/arginine repetitive matrix protein C-terminal
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
Janus kinase and microtubule-interacting protein 3
Signal-induced proliferation-associated 1-like protein 3
Jupiter microtubule associated homolog 1
Jupiter microtubule associated homolog 1, N-terminally processed
N-acetylthreonine; in Hematological and neurological expressed 1 protein, N-terminally processed
Dual specificity tyrosine-phosphorylation-regulated kinase 4
Zinc finger CCHC domain-containing protein 3
Cilia- and flagella-associated protein 73
Fibrinogen C domain-containing protein 1
Alanine--glyoxylate aminotransferase 2, mitochondrial
High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
Mediates immunoglobulin Fc fragment-binding
cAMP-dependent protein kinase type II-beta regulatory subunit
O-(5'-phospho-DNA)-tyrosine intermediate
Nervy homology region 2 (NHR2); essential for down-regulation of PFKFB3, PFKFB4 and PDK1 expression
Nervy homology region 3 (NHR3); essential for down-regulation of PFKFB3, PFKFB4 and PDK1 expression
ATP-binding cassette sub-family G member 8
Abolishes cholesterol transport activity, and nearly abolishes plant sterol transport.
Abolishes expression at the apical cell membrane. Strongly decreases cholesterol secretion into bile.
Mildly decreases cholesterol transport. No effect on plant sterol transport.
No effect on ATP-binding and on expression of both ABCG5 and ABCG8. No effect on sterol transport.
No effect on sterol transport; when associated with I-214.
No effect on sterol transport; when associated with S-216.
G2 and S phase-expressed protein 1 N-terminal
Heterogeneous nuclear ribonucleoprotein Q
Janus kinase and microtubule-interacting protein C-terminal
Sufficient for RNA-binding, interaction with NXF1-NXT1 heterodimer
N-acetyltransferase ESCO acetyl-transferase
Localizes in nucleus and cytoplasm. Localizes mainly in cytoplasm; when associated with 145-A--A-150.
Localizes in nucleus and cytoplasm. Localizes mainly in cytoplasm; when associated with 70-A--A-73.
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Loss of promotion of EKLF sumoylation; when associated with G-346 and A-356.
Loss of promotion of EKLF sumoylation; when associated with G-346 and G-351.
Loss of promotion of EKLF sumoylation; when associated with G-351 and A-356.
Loss of promotion of NCOA2 sumoylation. No effect on interaction with MSX1 or localization of either protein at the nuclear periphery.
No effect on interaction with MSX1 or localization of either protein at the nuclear periphery.
Neuronal PAS domain-containing protein 4
Reduces affinity for substrate and catalytic activity by about 50%.
Spermatogenesis-defective protein 39 homolog
Abolishes phosphorylation by GSK3B. Reduces phosphorylation by MAPK. Affects polarized cell migration. Increases RhoGAP catalytic activity.
Abolishes phosphorylation by GSK3B. Reduces phosphorylation by MAPK. No effect on polarized cell migration.
Has GTPase activity, required for proper localization
In ENU mutant Arhgap35-D34; mutant animals show hypodysplastic kidneys and neural tube closure defects; the number of ciliated cells and cilia average length are drastically reduced in the proximal tubules. Results in loss of activation of GTP hydrolysis.
Reduces phosphorylation by GSK3B by 50%. No effect on polarized cell migration.
Required for phospholipid binding and regulation of the substrate preference
Lysophosphatidic acid phosphatase type 6
Protein-lysine N-methyltransferase EEF2KMT
Interaction with coactivator LXXLL motif
Mice carrying this mutation show atrophic ovaries without oocytes, but no other visible phenotype.
tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
In strain: NJL/Msf, BLG2/Msf, MSM/Msf and SWN/Msf.
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
EF-hand domain-containing family member B
Results in attenuation of insulin secretion; increased protein stability.
Abolishes surface expression and channel activity.
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Reduces surface expression and abolishes channel activity.
Reduces surface expression and decreases current amplitude.
Reduces surface expression and disrupts channel closure.
Shifts channel activation to more negative voltage, slows channel opening and speeds up channel closure. Reduces sensitivity to activation by cAMP.
Shifts voltage dependence of activation to more negative values.
Shifts voltage dependence of activation to more positive values and abolishes pH-sensitivity.
Interleukin-1 receptor-associated kinase 1
Uncharacterized aarF domain-containing protein kinase 5
Leucine-rich repeat and guanylate kinase domain-containing protein
Sufficient for interaction with SHLD3 and MAD2L2
Zinc finger FYVE domain-containing protein 21
Not detected in nucleus. Redistributed in cytoplasm.
Glycine amidinotransferase, mitochondrial
Leucine-rich repeat-containing protein 69
A disintegrin and metalloproteinase with thrombospondin motifs 12
Peptidase M12B propeptide domain-containing protein
G-protein coupled receptor family C group 5 member B
Putative tyrosine-protein phosphatase auxilin
In mouse mutant chicory (ccy); reduced proportion of B cells in peripheral blood.
In mouse mutant endive (en); reduced proportion of B cells in peripheral blood.
Phosphofurin acidic cluster sorting protein 1
Membrane-spanning 4-domains subfamily A member 3
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
Succinate dehydrogenase assembly factor 4, mitochondrial
ADP-ribosylation factor GTPase-activating protein 3
Guanine nucleotide-binding protein subunit alpha-15
Histidine protein methyltransferase 1 homolog
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
Necessary for centriole targeting and microtubule association
Mitochondrial inner membrane protease subunit 1
Transmembrane domain-containing protein TMIGD3
Ribosome biogenesis protein NSA2 homolog
No loss of its ability to regulate TBX21-dependent gene expression or its ability to interact with SMARCA4; when associated with A-1388 and A-1390.
No loss of its ability to regulate TBX21-dependent gene expression or its ability to interact with SMARCA4; when associated with A-1388 and A-1468.
No loss of its ability to regulate TBX21-dependent gene expression or its ability to interact with SMARCA4; when associated with A-1390 and A-1468.
Protein phosphatase 1 regulatory subunit 15A
Protein phosphatase 1 regulatory subunit 15A/B C-terminal
Sodium/potassium-transporting ATPase subunit beta-3
Ubiquitin carboxyl-terminal hydrolase MINDY-3
Knockin mice hearts exhibit a severe combined COX and copper deficiency and a mislocalization of copper transporter protein CTR1 to the cytoplasm.
No effect on dimerization. No effect on inhibition of BMP signaling.
Reduces affinity for BMP2 and BMP4. Reduces inhibition of BMP2 signaling.
Reduces affinity for BMP2 and BMP4. Strongly reduces inhibition of BMP2 signaling.
Slightly reduces affinity for BMP2 and BMP4. No effect on inhibition of BMP2 signaling.
Strongly reduces affinity for BMP2 and BMP4. Reduces inhibition of BMP2 signaling.
Strongly reduces affinity for BMP2 and BMP4. Strongly reduces inhibition of BMP2 signaling.
Heat shock protein 75 kDa, mitochondrial
Constitutively nuclear. Strongly reduced interaction with FBXO4. Strongly reduced ubiquitination.
Promotes location to the nucleus. Reduces proteasomal degradation, but does not prevent ubiquitination.
Pyrin and HIN domain-containing protein 1