Major chimpanzee-specific structural changes in sperm development-associated genes.
DNA sequence and comparative analysis of chimpanzee chromosome 22.
Positive Selection and Multiple Losses of the LINE-1-Derived L1TD1 Gene in Mammals Suggest a Dual Role in Genome Defense and Pluripotency.
Emergence of primate genes by retrotransposon-mediated sequence transduction.
Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzee.
Primate evolution of an olfactory receptor cluster: diversification by gene conversion and recent emergence of pseudogenes.
MHC class I diversity in chimpanzees and bonobos.
Major histocompatibility complex class I diversity in a West African chimpanzee population: implications for HIV research.
Molecular and immunological significance of chimpanzee major histocompatibility complex haplotypes for hepatitis C virus immune response and vaccination studies.
Nucleotide sequences of chimpanzee MHC class I alleles: evidence for trans-species mode of evolution.
Population distribution of human flavin-containing monooxygenase form 3: gene polymorphisms.
Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence.
Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.
Adaptive selection of mitochondrial complex I subunits during primate radiation.
Diversification of bitter taste receptor gene family in western chimpanzees.
Eco-Geographical Diversification of Bitter Taste Receptor Genes (TAS2Rs) among Subspecies of Chimpanzees (Pan troglodytes).
Evolution of bitter taste receptors in humans and apes.
Curated eutherian third party data gene data sets.
Third party annotation gene data set of eutherian lysozyme genes.
Characterization of the genes encoding carbonic anhydrase I of chimpanzee and gorilla: comparative analysis of 5' flanking erythroid-specific promoter sequences.
Evolution of the mannose-binding lectin gene in primates.
Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.
Human-chimpanzee DNA sequence variation in the four major genes of the renin angiotensin system.
A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes.
Molecular cloning and characterization of EPI-1, the major protein in chimpanzee (Pan troglodytes) cauda epididymal fluid.
The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach.
Comparative genomic analysis of eutherian ribonuclease A genes.
Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.
Chimpanzee apolipoprotein H (beta2-glycoprotein I): report on the gene structure, a common polymorphism, and a high prevalence of antiphospholipid antibodies.
Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas.
Accelerated evolution of nervous system genes in the origin of Homo sapiens.
Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates.
Comparative sequence analyses reveal rapid and divergent evolutionary changes of the WFDC locus in the primate lineage.
Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Patterns of evolution of host proteins involved in retroviral pathogenesis.
Genomic analysis of common chimpanzee major histocompatibility complex class I genes.
Natural selection in the TLR-related genes in the course of primate evolution.
Contribution of a common single-nucleotide polymorphism to the genetic predisposition for erythropoietic protoporphyria.
Human-specific amino acid changes found in 103 protein-coding genes.
The Breadth of Antiviral Activity of Apobec3DE in Chimpanzees Has Been Driven by Positive Selection.
Adaptive evolution of SCML1 in primates, a gene involved in male reproduction.
Barth syndrome: TAZ gene mutations, mRNAs, and evolution.
Comparative analyses of multi-species sequences from targeted genomic regions.
Identification of Gasz, an evolutionarily conserved gene expressed exclusively in germ cells and encoding a protein with four ankyrin repeats, a sterile-alpha motif, and a basic leucine zipper.
Evolution of the relaxin-like peptide family.
Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes.
A potent neutralizing monoclonal antibody can discriminate amongst IFNgamma from various primates with greater specificity than can the human IFNgamma receptor complex.
Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans.
A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence.
Mapping of chimpanzee full-length cDNAs onto the human genome unveils large potential divergence of the transcriptome.
A unique amino acid deletion in the chimpanzee cyclin T1 does not affect Tat trans-activation of HIV.
Comparison of DNA and protein polymorphisms between humans and chimpanzees.
Evolution of the NANOG pseudogene family in the human and chimpanzee genomes.
Alu-mediated 100-kb deletion in the primate genome: the loss of the agouti signaling protein gene in the lesser apes.
Investigation of the role of the agouti signaling protein gene (ASIP) in coat color evolution in primates.
Comparison of chimpanzee and human leukocyte Ig-like receptor genes reveals framework and rapidly evolving genes.
Structure, gene expression, and evolution of primate copper chaperone for superoxide dismutase.
Evolution of pro-protamine P2 genes in primates.
Rapid evolution of male reproductive genes in the descent of man.
Comparative genomic analysis of eutherian adiponectin genes.
Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain.
The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs).
Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates.
Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.
Emergence of young human genes after a burst of retroposition in primates.
Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.
Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.
Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.
Evolution of the human ASPM gene, a major determinant of brain size.
A CD4 domain important for HIV-mediated syncytium formation lies outside the virus binding site.
Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus.
Genetic subspecies diversity of the chimpanzee CD4 virus-receptor gene.
Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.
Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
Comparative genomic analysis of the MHC: the evolution of class I duplication blocks, diversity and complexity from shark to man.
Evolution of a pigmentation gene, the melanocortin-1 receptor, in primates.
Variation of the melanocortin 1 receptor gene in the macaques.
The identification and functional implications of human-specific "fixed" amino acid substitutions in the glutamate receptor family.
Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition.
Evolutionary sequence comparisons using high-density oligonucleotide arrays.
Genomics, evolution, and expression of TBPL2, a member of the TBP family.
Beta-defensin 1 gene variability among non-human primates.
Expression of beta-defensin-1 in chimpanzee (Pan troglodytes) airways.
Evolutionary conservation and diversification of Rh family genes and proteins.
New insights into the Rh superfamily of genes and proteins in erythroid cells and nonerythroid tissues.
Cloning and expression of interleukin-3 genes of chimpanzee and New World monkeys.
Differential NKp30 inducibility in chimpanzee NK cells and conserved NK cell phenotype and function in long-term HIV-1-infected animals.
The chimpanzee GH locus: composition, organization, and evolution.
Third party data gene data set of eutherian growth hormone genes.
Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity.
Expression, candidate gene, and population studies of the melanocortin 5 receptor.
A history of recurrent positive selection at the toll-like receptor 5 in primates.
Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene.
Sequence variation and haplotype structure at the Human HFE Locus.
Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees.
Increased constraints on MC4R during primate and human evolution.
Elevated gene expression levels distinguish human from non-human primate brains.
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family.
CYP3 phylogenomics: evidence for positive selection of CYP3A4 and CYP3A7.
Human adaptive evolution at myostatin (GDF8), a regulator of muscle growth.
Characterization of interleukin-8 receptors in non-human primates.
Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils.
Infectious amyloid precursor gene sequences in primates used for experimental transmission of human spongiform encephalopathy.
Prion protein gene variation among primates.
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus.
Chimpanzee CXCR4 and CCR5 act as coreceptors for HIV type 1.
Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains.
HIV type 1 subtypes, coreceptor usage, and CCR5 polymorphism.
Sequence evolution of the CCR5 chemokine receptor gene in primates.
Sequence of chemokine receptor gene CCR5 in chimpanzees, a natural HIV type 1 host.
Evolution of fucosyltransferase genes in vertebrates.
Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.
The structural evolution of a P2Y-like G-protein-coupled receptor.
The evolution and genomic landscape of CGB1 and CGB2 genes.
Comparative genomic analysis of eutherian kallikrein genes.
Analysis of variation in the human beta-globin gene cluster using a novel DHPLC technique.
Primate hemoglobins: some sequences and some proposals concerning the character of evolution and mutation.
Structure of the delta-chain of chimpanzee haemoglobin A 2.
Interspecies subtractive hybridization of cDNA from human and chimpanzee brains.
Identification of conserved potentially regulatory sequences of the SRY gene from 10 different species of mammals.
Nuclear versus Mitochondrial DNA: Evidence for Hybridization in Colobine Monkeys.
Rapid sequence evolution of the mammalian sex-determining gene SRY.
Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4.
Molecular evolution of the primate developmental genes MSX1 and PAX9.
Sequences and predicted structures of chimpanzee STRL33 (Bonzo) and gpr15 (BOB).
Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4).
The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor.
Molecular evolution of adrenarche: structural and functional analysis of p450c17 from four primate species.
Comparative genomic analysis of eutherian interferon-gamma-inducible GTPases.
Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans.
MEPE evolution in mammals reveals regions and residues of prime functional importance.
Cloning of interleukin-4 delta2 splice variant (IL-4delta2) in chimpanzee and cynomolgus macaque: phylogenetic analysis of delta2 splice variant appearance, and implications for the study of IL-4-driven immune processes.
Primate DAX1, SRY, and SOX9: evolutionary stratification of sex-determination pathway.
Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution.
A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes.
Prevention of rhinovirus infection in chimpanzees by soluble intercellular adhesion molecule-1.
A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state.
Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon.
Diverse fates of paralogs following segmental duplication of telomeric genes.
A system for receptor functional analysis based on c-fos mRNA expression: analysis of GnRH receptors as a test system.
Tau gene (MAPT) sequence variation among primates.
A new superfamily of protein-O-fucosyltransferases, alpha2-fucosyltransferases, and alpha6-fucosyltransferases: phylogeny and identification of conserved peptide motifs.
Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene.
Evidence on human origins from haemoglobins of African apes.
Structural and evolutionary analysis of the two chimpanzee alpha-globin mRNAs.
The characterization of the tryptic peptides from the hemoglobin of the chimpanzee (Pan troglodytes).
Identification of two novel primate-specific genes in DSCR.
Initial description of primate-specific cystine-knot Prometheus genes and differential gene expansions of D-dopachrome tautomerase genes.
The evolutionary history of the CD209 (DC-SIGN) family in humans and non-human primates.
Contrasting levels of DNA polymorphism at the autosomal and X-linked visual color pigment loci in humans and squirrel monkeys.
The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids.
Evolution of the cystatin B gene: implications for the origin of its variable dodecamer tandem repeat in humans.
Origin of INSL3-mediated testicular descent in therian mammals.
Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates.
Multiple promoter and splicing mRNA variants of the epididymis-specific gene EP2.
Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood.
NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.
NEDD8nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.
Accelerated protein evolution and origins of human-specific features: Foxp2 as an example.
No Distinction of Orthology/Paralogy between Human and Chimpanzee Rh Blood Group Genes.
Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception.
Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.
Antiretroelement activity of APOBEC3H was lost twice in recent human evolution.
Structural basis of chimpanzee APOBEC3H dimerization stabilized by double-stranded RNA.
Rapid evolution of a unique family of primate ribonuclease genes.
Sequence variation at two eosinophil-associated ribonuclease loci in humans.
Comparison of class I MHC alleles in humans and apes.
Expansion and divergence of the GH locus between spider monkey and chimpanzee.
Analysis of evolutionary conservation in CD1d molecules among primates.
Neuroglobin and cytoglobin: genes, proteins and evolution.
Evolution of alpha 2-fucosyltransferase genes in primates: relation between an intronic Alu-Y element and red cell expression of ABH antigens.
A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas.
Cloning and nucleotide sequence of the chimpanzee c-myc gene.
The effects of sequence length and oligonucleotide mismatches on 5' exonuclease assay efficiency.
Novel member of the CD209 (DC-SIGN) gene family in primates.
Rhesus and chimpanzee DC-SIGN act as HIV/SIV gp120 trans-receptors, similar as human DC-SIGN.
Common chimpanzees have greater diversity than humans at two of the three highly polymorphic MHC class I genes.
Patr-A and B, the orthologues of HLA-A and B, present hepatitis C virus epitopes to CD8+ cytotoxic T cells from two chronically infected chimpanzees.
Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity.
Evolution of the hepcidin gene in primates.
Primate-specific spliced PMCHL RNAs are non-protein coding in human and macaque tissues.
Protein kinase R reveals an evolutionary model for defeating viral mimicry.
Restriction of foamy viruses by APOBEC cytidine deaminases.
Molecular genetics of chimpanzee Rh-related genes: their relationship with the R-C-E-F blood group system, the chimpanzee counterpart of the human rhesus system.
The complexity of selection at the major primate beta-defensin locus.
Molecular evolution of the N-formyl peptide and C5a receptors in non-human primates.
Nucleotide sequence of a chimpanzee DOB cDNA clone.
Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family.
Detection of two distinct forms of apoC-I in great apes.
Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes.
Proteogenomic Review of the Changes in Primate apoC-I during Evolution.
Structure, molecular evolution, and gene expression of primate superoxide dismutases.
Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene.
Rejection of the 'flying primate' hypothesis by phylogenetic evidence from the epsilon-globin gene.
Death and resurrection of the human IRGM gene.
RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta.
Loss of N-glycolylneuraminic acid in human evolution: implications for sialic acid recognition by siglecs.
Differential L1 regulation in pluripotent stem cells of humans and apes.
Analysis of the reticulon gene family demonstrates the absence of the neurite growth inhibitor Nogo-A in fish.
Human glycolipid transfer protein (GLTP) genes: organization, transcriptional status and evolution.
A gene recently inactivated in human defines a new olfactory receptor family in mammals.
Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins.
Characterization of the transcription unit and two processed pseudogenes of chimpanzee triosephosphate isomerase (TPI).
Episodic adaptive evolution of primate lysozymes.
Chimpanzee fetal G gamma and A gamma globin gene nucleotide sequences provide further evidence of gene conversions in hominine evolution.
Chimpanzee foetal haemoglobin: structure and heterogeneity of the gamma chain.
Reexamination of the African hominoid trichotomy with additional sequences from the primate beta-globin gene cluster.
Sequence, organization, and evolution of Rh50 glycoprotein genes in nonhuman primates.
A genomic region evolving toward different GC contents in humans and chimpanzees indicates a recent and regionally limited shift in the mutation pattern.
Mobilization of an ERV9 human endogenous retroviral element during primate evolution.
Diversifying selection of the tumor-growth promoter angiogenin in primate evolution.
Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12.
Interferon-inducible gene expression in chimpanzee liver infected with hepatitis C virus.
Search for genes positively selected during primate evolution by 5'-end-sequence screening of cynomolgus monkey cDNAs.
Evolution of the primate androgen receptor: a structural basis for disease.
Recognition and accommodation at the androgen receptor coactivator binding interface.
The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility.
A second uniquely human mutation affecting sialic acid biology.
Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates.
Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in Mammals.
Primary sequence of an alternatively spliced form of CR1. Candidate for the 75,000 M(r) complement receptor expressed on chimpanzee erythrocytes.
The rise and fall of the chemoattractant receptor GPR33.
Comparative genomics reveals gene-specific and shared regulatory sequences in the spermatid-expressed mammalian Odf1, Prm1, Prm2, Tnp1, and Tnp2 genes.
Evolution of protamine P1 genes in primates.
Characterization of a nuclear deformed epidermal autoregulatory factor-1 (DEAF-1)-related (NUDR) transcriptional regulator protein.
Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ.
Lineage-specific homogenization of the polyubiquitin gene among human and great apes.
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.
Evolution-Guided Identification of Antiviral Specificity Determinants in the Broadly Acting Interferon-Induced Innate Immunity Factor MxA.
Divergent evolution of the prolactin-inducible protein gene and related genes in the mouse genome.
Origin and evolution of gene for prolactin-induced protein.
Evolution of the primate beta-globin gene region. High rate of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee.
Cloning, sequencing and expression in Escherichia coli of cDNA for a non-A, non-B hepatitis-associated microtubular aggregates protein.
Isolation and purification of a non-A, non-B hepatitis-associated microtubular aggregates protein.
Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics.
A candidate prostate cancer susceptibility gene at chromosome 17p.
HLA-A and B polymorphisms predate the divergence of humans and chimpanzees.
MHC-F DNA sequences in bonobo, gorilla and orangutan.
Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily.
Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species.
Co-Evolution of Primate SAMHD1 and Lentivirus Vpx Leads to the Loss of the vpx Gene in HIV-1 Ancestor.
Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein.
The Ability of Primate Lentiviruses to Degrade the Monocyte Restriction Factor SAMHD1 Preceded the Birth of the Viral Accessory Protein Vpx.
An evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene family.
Differential Evolutionary Fate of an Ancestral Primate Endogenous Retrovirus Envelope Gene, the EnvV Syncytin, Captured for a Function in Placentation.
Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.
Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia.
Osteocalcin protein sequences of Neanderthals and modern primates.
Differential binding of urokinase and peptide antagonists to the urokinase receptor: evidence from characterization of the receptor in four primate species.
Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.
Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians.
Comprehensive search for intra- and inter-specific sequence polymorphisms among coding envelope genes of retroviral origin found in the human genome: genes and pseudogenes.
Evolutionary variability of cytochrome c primary structures.
Implications of natural selection in shaping 99.4% nonsynonymous DNA identity between humans and chimpanzees: enlarging genus Homo.
Conversion and compensatory evolution of the gamma-crystallin genes and identification of a cataractogenic mutation that reverses the sequence of the human CRYGD gene to an ancestral state.
Genetic evidence of a strong functional constraint of neurotrypsin during primate evolution.
Analysis of human and primate CD2 molecules by protein sequence and epitope mapping with anti-human CD2 antibodies.
Adaptive evolution of primate TRIM5alpha, a gene restricting HIV-1 infection.
All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction.
High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans.
Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain.
The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates.
Molecular evolution of FOXP2, a gene involved in speech and language.
Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses.
Characterization of the MHC class I-related MR1 locus in nonhuman primates.
Alpha-synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates.
Mass spectral analyses of the two major apolipoproteins of great ape high density lipoproteins.
Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample.