Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
Genetic requirements for mycobacterial survival during infection.
Identification of inhibitors against Mycobacterium tuberculosis thiamin phosphate synthase, an important target for the development of anti-TB drugs.
Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis.
Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis.
Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes.
Rv0518, a nutritive stress inducible GDSL lipase of Mycobacterium tuberculosis, enhanced intracellular survival of bacteria by cell wall modulation.
Role of PPE18 protein in intracellular survival and pathogenicity of Mycobacterium tuberculosis in mice.
The PPE18 of Mycobacterium tuberculosis interacts with TLR2 and activates IL-10 induction in macrophage.
The PPE18 protein of Mycobacterium tuberculosis inhibits NF-kappaB/rel-mediated proinflammatory cytokine production by upregulating and phosphorylating suppressor of cytokine signaling 3 protein.
The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence.
Expression of the ompATb operon accelerates ammonia secretion and adaptation of Mycobacterium tuberculosis to acidic environments.
Assessing the essentiality of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants.
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.
Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose.
DprE1 is a vulnerable tuberculosis drug target due to its cell wall localization.
Genes required for mycobacterial growth defined by high density mutagenesis.
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.
Structure, dynamics, and interaction of Mycobacterium tuberculosis (Mtb) DprE1 and DprE2 examined by molecular modeling, simulation, and electrostatic studies.
Biochemical and physiological characterization of the GTP-binding protein Obg of Mycobacterium tuberculosis.
Cloning and characterization of GTP-binding proteins of Mycobacterium tuberculosis H37Rv.
Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition.
The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol.
Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis.
Identification of Nudix hydrolase family members with an antimutator role in Mycobacterium tuberculosis and Mycobacterium smegmatis.
Mce3R, a TetR-type transcriptional repressor, controls the expression of a regulon involved in lipid metabolism in Mycobacterium tuberculosis.
ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism.
Mycobacterium tuberculosis invasion and traversal across an in vitro human blood-brain barrier as a pathogenic mechanism for central nervous system tuberculosis.
Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages.
Identification of microbial dimethylarginine dimethylaminohydrolase enzymes.
Adenylylation and catalytic properties of Mycobacterium tuberculosis glutamine synthetase expressed in Escherichia coli versus mycobacteria.
Expression and efficient export of enzymatically active Mycobacterium tuberculosis glutamine synthetase in Mycobacterium smegmatis and evidence that the information for export is contained within the protein.
Glutamine synthetase GlnA1 is essential for growth of Mycobacterium tuberculosis in human THP-1 macrophages and guinea pigs.
Glutamine synthetase of Mycobacterium tuberculosis: extracellular release and characterization of its enzymatic activity.
Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo.
Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation.
Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors.
Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights.
Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly-L-glutamate/glutamine cell wall structure, and bacterial replication.
Trisubstituted imidazoles as Mycobacterium tuberculosis glutamine synthetase inhibitors.
Catabolism of the last two steroid rings in Mycobacterium tuberculosis and other bacteria.
Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase.
Purification and molecular characterization of a novel diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv.
Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv.
Structural insights into the novel diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv.
A novel lipase belonging to the hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in Mycobacterium tuberculosis.
Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection.
Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex.
Biochemical and transcription analysis of acetohydroxyacid synthase isoforms in Mycobacterium tuberculosis identifies these enzymes as potential targets for drug development.
Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence.
Systematic genetic nomenclature for type VII secretion systems.
Expression and characterization of Mycobacterium tuberculosis CYP144: common themes and lessons learned in the M. tuberculosis P450 enzyme family.
Proteasomal control of cytokinin synthesis protects Mycobacterium tuberculosis against nitric oxide.
Intra- and intermolecular domain interactions among novel two-component system proteins coded by Rv0600c, Rv0601c and Rv0602c of Mycobacterium tuberculosis.
Probing the nucleotide binding and phosphorylation by the histidine kinase of a novel three-protein two-component system from Mycobacterium tuberculosis.
Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria.
Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis.
Examination of Mycobacterium tuberculosis sigma factor mutants using low-dose aerosol infection of guinea pigs suggests a role for SigC in pathogenesis.
Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis.
WhiB5, a transcriptional regulator that contributes to Mycobacterium tuberculosis virulence and reactivation.
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.
Molecular basis for DarT ADP-ribosylation of a DNA base.
The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA.
Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution.
Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry.
Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG.
Cloning, sequence determination, and expression of a 32-kilodalton-protein gene of Mycobacterium tuberculosis.
Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis.
Evidence for three separate genes encoding the proteins of the mycobacterial antigen 85 complex.
Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity.
Novel insights into the genetics, biochemistry, and immunocytochemistry of the 30-kilodalton major extracellular protein of Mycobacterium tuberculosis.
Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis.
Single nucleotide polymorphisms in cell wall biosynthesis-associated genes and phylogeny of Mycobacterium tuberculosis lineages.
The Mycobacterium tuberculosis Ag85A is a novel diacylglycerol acyltransferase involved in lipid body formation.
A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism.
A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis.
Rv0802c acetyltransferase from Mycobacterium tuberculosis H37Rv.
Rv0802c from Mycobacterium tuberculosis: the first structure of a succinyltransferase with the GNAT fold.
Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis.
Selection of transposon mutants of Mycobacterium tuberculosis with increased macrophage infectivity identifies fadD23 to be involved in sulfolipid production and association with macrophages.
Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids.
Characterization of Mycobacterium tuberculosis diaminopimelic acid epimerase: paired cysteine residues are crucial for racemization.
Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis.
Use of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimerase.
A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor.
A mycobacterial operon essential for virulence in vivo and invasion and intracellular persistence in macrophages.
A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis.
Interaction and modulation of two antagonistic cell wall enzymes of mycobacteria.
Interaction of Mycobacterium tuberculosis virulence factor RipA with chaperone MoxR1 is required for transport through the TAT secretion system.
Peptidoglycan remodeling in Mycobacterium tuberculosis: comparison of structures and catalytic activities of RipA and RipB.
Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation.
Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis.
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis.
ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria.
A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications.
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors.
Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of riboflavin synthase and lumazine synthase.
Experimental determination of translational starts using peptide mass mapping and tandem mass spectrometry within the proteome of Mycobacterium tuberculosis.
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis.
Characterization of an aldolase-dehydrogenase complex from the cholesterol degradation pathway of Mycobacterium tuberculosis.
Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.
Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis.
Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program.
Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection.
Phosphofructokinases A and B from Mycobacterium tuberculosis display different catalytic properties and allosteric regulation.
Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin.
A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection.
Crystal structure of the 65-kilodalton heat shock protein, chaperonin 60.2, of Mycobacterium tuberculosis.
Detection and identification of mycobacteria by PCR-RFLP method.
GroEL2 of Mycobacterium tuberculosis reveals the importance of structural pliability in chaperonin function.
Mycobacterium tuberculosis Cpn60.2 (GroEL2) blocks macrophage apoptosis via interaction with mitochondrial mortalin.
Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages.
Mycobacterium tuberculosis GroEL homologues unusually exist as lower oligomers and retain the ability to suppress aggregation of substrate proteins.
Mycobacterium tuberculosis GroEL2 modulates dendritic cell responses.
Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.
Mycobacterium tuberculosis WhiB1 represses transcription of the essential chaperonin GroEL2.
Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface.
Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals.
Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing.
The 65-kilodalton antigen of Mycobacterium tuberculosis.
The dimeric structure of the Cpn60.2 chaperonin of Mycobacterium tuberculosis at 2.8 A reveals possible modes of function.
The unusual mycobacterial chaperonins: evidence for in vivo oligomerization and specialization of function.
Deep N-terminomics of Mycobacterium tuberculosis H37Rv extensively correct annotated encoding genes.
Characterization and transcriptome analysis of Mycobacterium tuberculosis persisters.
Characterization of a novel esterase Rv0045c from Mycobacterium tuberculosis.
Crystal structure of a novel esterase Rv0045c from Mycobacterium tuberculosis.
Crystallization and preliminary X-ray analysis of a novel esterase Rv0045c from Mycobacterium tuberculosis.
Distinct substrate selectivity of a metabolic hydrolase from Mycobacterium tuberculosis.
Transition metal cation inhibition of Mycobacterium tuberculosis esterase RV0045C.
Characterization of culture filtrate proteins Rv1197 and Rv1198 of ESAT-6 family from Mycobacterium tuberculosis H37Rv.
Comparative proteome analysis of culture supernatant proteins of Mycobacterium tuberculosis H37Rv and H37Ra.
Mycobacterium tuberculosis RNA expression patterns in sputum bacteria indicate secreted Esx factors contributing to growth are highly expressed in active disease.
Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis.
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling.
Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis.
Genomic organization of the mycobacterial sigma gene cluster.
MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis.
Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.
Role of the extracytoplasmic-function sigma factor sigma(H) in Mycobacterium tuberculosis global gene expression.
The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages.
The Mycobacterium tuberculosis sigma factor sigmaB is required for full response to cell envelope stress and hypoxia in vitro, but it is dispensable for in vivo growth.
The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase.
The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis.
Transcription of two sigma 70 homologue genes, sigA and sigB, in stationary-phase Mycobacterium tuberculosis.
Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferase.
Analyzing the regulatory role of the HigA antitoxin within Mycobacterium tuberculosis.
Experimental determination of translational start sites resolves uncertainties in genomic open reading frame predictions - application to Mycobacterium tuberculosis.
Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA.
Multiple toxin-antitoxin systems in Mycobacterium tuberculosis.
SecB-like chaperone controls a toxin-antitoxin stress-responsive system in Mycobacterium tuberculosis.
Redundant function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis cyclopropanation of oxygenated mycolates.
S-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases.
The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid.
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.
Biochemical characterization of a chromosomal toxin-antitoxin system in Mycobacterium tuberculosis.
Characterization of mRNA interferases from Mycobacterium tuberculosis.
Expression of Mycobacterium tuberculosis Rv1991c using an arabinose-inducible promoter demonstrates its role as a toxin.
MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs.
Noncognate Mycobacterium tuberculosis toxin-antitoxins can physically and functionally interact.
Formation of dTDP-rhamnose is essential for growth of mycobacteria.
The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD.
Enzymatic beta-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA.
High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism.
Siroheme- and [Fe4-S4]-dependent NirA from Mycobacterium tuberculosis is a sulfite reductase with a covalent Cys-Tyr bond in the active site.
Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis.
Interaction analysis of TcrX/Y two component system from Mycobacterium tuberculosis.
Purification and characterization of the acetyl-CoA synthetase from Mycobacterium tuberculosis.
Reversible acetylation and inactivation of Mycobacterium tuberculosis acetyl-CoA synthetase is dependent on cAMP.
The Mycobacterium tuberculosis purine biosynthetic pathway: isolation and characterization of the purC and purL genes.
Characterization of a two-component system, devR-devS, of Mycobacterium tuberculosis.
Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance.
Crystal structure of FadA2 thiolase from Mycobacterium tuberculosis and prediction of its substrate specificity and membrane-anchoring properties.
Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice.
Metabolic network for the biosynthesis of intra- and extracellular alpha-glucans required for virulence of Mycobacterium tuberculosis.
Acquired resistance of Mycobacterium tuberculosis to bedaquiline.
Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux system.
Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis.
PE_PGRS antigens of Mycobacterium tuberculosis induce maturation and activation of human dendritic cells.
The multifunctional PE_PGRS11 protein from Mycobacterium tuberculosis plays a role in regulating resistance to oxidative stress.
Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose.
Functional analysis and enzyme characterization of mannose-1-phosphate guanylyl transferase (ManB) from Mycobacterium tuberculosis.
A mycobacterium ESX-1-secreted virulence factor with unique requirements for export.
Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion.
Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence.
Mycobacterium tuberculosis EspB protein suppresses interferon-gamma-induced autophagy in murine macrophages.
Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence.
Serological expression cloning and immunological evaluation of MTB48, a novel Mycobacterium tuberculosis antigen.
Structure of EspB from the ESX-1 type VII secretion system and insights into its export mechanism.
Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis.
Structure of the mycosin-1 protease from the mycobacterial ESX-1 protein type VII secretion system.
The regulatory elements of the Mycobacterium tuberculosis gene Rv3881c function efficiently in Escherichia coli.
Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis.
Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas.
Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis.
Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampicin resistance, and pathogenesis.
Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis isolates from Brazil.
Mycobacterium tuberculosis RbpA protein is a new type of transcriptional activator that stabilizes the sigma A-containing RNA polymerase holoenzyme.
The rpoB gene of Mycobacterium tuberculosis.
Definition of the mycobacterial SOS box and use to identify LexA-regulated genes in Mycobacterium tuberculosis.
DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosis.
An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kDa major secretory protein (Antigen 85B), a mycolyl transferase.
Nucleotide sequence of the 85B-protein gene of Mycobacterium bovis BCG and Mycobacterium tuberculosis.
Cloning, expression, purification and preliminary crystallographic analysis of the RNase HI domain of the Mycobacterium tuberculosis protein Rv2228c as a maltose-binding protein fusion.
Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis.
Specific interaction between Mycobacterium tuberculosis lipoprotein-derived peptides and target cells inhibits mycobacterial entry in vitro.
Cloning, expression, purification, crystallization and preliminary crystallographic analysis of Rv1698, an outer membrane channel protein from Mycobacterium tuberculosis.
Copper resistance is essential for virulence of Mycobacterium tuberculosis.
Identification of outer membrane proteins of Mycobacterium tuberculosis.
Rv1698 of Mycobacterium tuberculosis represents a new class of channel-forming outer membrane proteins.
Investigating a putative transcriptional regulatory protein encoded by Rv1719 gene of Mycobacterium tuberculosis.
Organization of the origins of replication of the chromosomes of Mycobacterium smegmatis, Mycobacterium leprae and Mycobacterium tuberculosis and isolation of a functional origin from M. smegmatis.
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.
Validation of CoaBC as a bactericidal target in the coenzyme A pathway of Mycobacterium tuberculosis.
Aminopyrazinamides: novel and specific GyrB inhibitors that kill replicating and nonreplicating Mycobacterium tuberculosis.
Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations.
Crystal structure of DNA gyrase B' domain sheds lights on the mechanism for T-segment navigation.
First functional characterization of a singly expressed bacterial type II topoisomerase: the enzyme from Mycobacterium tuberculosis.
Mechanisms for defining supercoiling set point of DNA gyrase orthologs: II. The shape of the GyrA subunit C-terminal domain (CTD) is not a sole determinant for controlling supercoiling efficiency.
Mutagenesis in the alpha3alpha4 GyrA helix and in the Toprim domain of GyrB refines the contribution of Mycobacterium tuberculosis DNA gyrase to intrinsic resistance to quinolones.
Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion.
Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes.
Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.
Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes.
Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: structure-activity relationship and in vivo efficacy in a mouse model of tuberculosis.
Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
The pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex.
The role of Ca(2+) in the activity of Mycobacterium tuberculosis DNA gyrase.
The conserved hypothetical protein Rv0574c is required for cell wall integrity, stress tolerance, and virulence of Mycobacterium tuberculosis.
Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states.
Structural and functional characterization of Rv0792c from Mycobacterium tuberculosis: identifying small molecule inhibitor against HutC protein.
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.
Lansoprazole is an antituberculous prodrug targeting cytochrome bc1.
Biochemical and molecular analysis of phospholipase C and phospholipase D activity in mycobacteria.
Evidence for the cytotoxic effects of Mycobacterium tuberculosis phospholipase C towards macrophages.
Phospholipases C are involved in the virulence of Mycobacterium tuberculosis.
Effect of PstS sub-units or PknD deficiency on the survival of Mycobacterium tuberculosis.
Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter.
Structure of the Mycobacterium tuberculosis antigen 88, a protein related to the Escherichia coli PstA periplasmic phosphate permease subunit.
Crystal structure of the apo forms of psi 55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft.
PepD participates in the mycobacterial stress response mediated through MprAB and SigE.
Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis.
Targeting multidrug resistant Mycobacterium tuberculosis HtrA2 with identical chemical entities of fluoroquinolones.
The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein.
VapC20 of Mycobacterium tuberculosis cleaves the sarcin-ricin loop of 23S rRNA.
Purification, characterization, and genetic analysis of Mycobacterium tuberculosis urease, a potentially critical determinant of host-pathogen interaction.
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis.
In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems.
Inactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt(1) by carbapenems and cephalosporins.
Structures of free and inhibited forms of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis.
The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidation.
Arginine in the FARM and SARM: a role in chain-length determination for arginine in the aspartate-rich motifs of isoprenyl diphosphate synthases from Mycobacterium tuberculosis.
Insight into isoprenoid biosynthesis by functional analysis of isoprenyl diphosphate synthases from Mycobacterium vanbaalenii and Mycobacterium tuberculosis.
Functional characterization of PknI-Rv2159c interaction in redox homeostasis of Mycobacterium tuberculosis.
In silico and experimental validation of protein-protein interactions between PknI and Rv2159c from Mycobacterium tuberculosis.
Role of a putative alkylhydroperoxidase Rv2159c in the oxidative stress response and virulence of Mycobacterium tuberculosis.
Rv2358 and FurB: two transcriptional regulators from Mycobacterium tuberculosis which respond to zinc.
The Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc.
Biochemical evidence for relaxed substrate specificity of Nalpha-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis.
Stealth proteins: in silico identification of a novel protein family rendering bacterial pathogens invisible to host immune defense.
Structural insights into 3Fe-4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450.
Mycobacterium tuberculosis type III-A CRISPR/Cas system crRNA and its maturation have atypical features.
A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase.
Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase.
Synthesis of natural product-inspired inhibitors of Mycobacterium tuberculosis mycothiol-associated enzymes: the first inhibitors of GlcNAc-Ins deacetylase.
Crystallization and preliminary X-ray characterization of the glpX-encoded class II fructose-1,6-bisphosphatase from Mycobacterium tuberculosis.
The Mycobacterium tuberculosis Rv1099c gene encodes a GlpX-like class II fructose 1,6-bisphosphatase.
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.
glpX gene of Mycobacterium tuberculosis: heterologous expression, purification, and enzymatic characterization of the encoded fructose 1,6-bisphosphatase II.
glpx gene in Mycobacterium tuberculosis is required for in vitro gluconeogenic growth and in vivo survival.
Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.
Structural mechanics of the pH-dependent activity of beta-carbonic anhydrase from Mycobacterium tuberculosis.
Structure and function of carbonic anhydrases from Mycobacterium tuberculosis.
Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis.
Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis.
Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A.
Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III.
Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis.
Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates.
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH.
The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue.
Mycobacterium tuberculosis with disruption in genes encoding the phosphate binding proteins PstS1 and PstS2 is deficient in phosphate uptake and demonstrates reduced in vivo virulence.
Three different putative phosphate transport receptors are encoded by the Mycobacterium tuberculosis genome and are present at the surface of Mycobacterium bovis BCG.
Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 A resolution - a potential target for anti-tuberculosis drug discovery.
Acta Crystallogr. F Struct. Biol. Commun.
A structural characterization of the isoniazid Mycobacterium tuberculosis drug target, Rv2971, in its unliganded form.
Crystal structure and comparative functional analyses of a Mycobacterium aldo-keto reductase.
Recognition of specific immunogenic antigens with potential diagnostic value in multi-drug resistant Mycobacterium tuberculosis inducing humoral immunity in MDR-TB patients.
PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria.
A family of autocrine growth factors in Mycobacterium tuberculosis.
Global expression profiling of strains harbouring null mutations reveals that the five rpf-like genes of Mycobacterium tuberculosis show functional redundancy.
Proteins of the Rpf family: immune cell reactivity and vaccination efficacy against tuberculosis in mice.
The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro.
The Mycobacterium tuberculosis cysD and cysNC genes form a stress-induced operon that encodes a tri-functional sulfate-activating complex.
Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis.
The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-beta-synthase domain.
Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition.
Cloning and characterization of a novel PE_PGRS60 protein (Rv3652) of Mycobacterium tuberculosis H37 Rv exhibit fibronectin-binding property.
A novel copper-responsive regulon in Mycobacterium tuberculosis.
The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence.
pheA (Rv3838c) of Mycobacterium tuberculosis encodes an allosterically regulated monofunctional prephenate dehydratase that requires both catalytic and regulatory domains for optimum activity.
PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis.
Individual Mycobacterium tuberculosis universal stress protein homologues are dispensable in vitro.
3-Keto-5alpha-steroid Delta(1)-dehydrogenase from Rhodococcus erythropolis SQ1 and its orthologue in Mycobacterium tuberculosis H37Rv are highly specific enzymes that function in cholesterol catabolism.
Activity of 3-ketosteroid 9alpha-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis.
The role of 3-ketosteroid 1(2)-dehydrogenase in the pathogenicity of Mycobacterium tuberculosis.
Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner.
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes.
An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis.
Characterization of the phosphorylation sites of Mycobacterium tuberculosis serine/threonine protein kinases, PknA, PknD, PknE, and PknH by mass spectrometry.
Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis.
Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice.
EmbR, a regulatory protein with ATPase activity, is a substrate of multiple serine/threonine kinases and phosphatase in Mycobacterium tuberculosis.
Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase.
PknH, a transmembrane Hank's type serine/threonine kinase from Mycobacterium tuberculosis is differentially expressed under stress conditions.
Structure of the sensor domain of Mycobacterium tuberculosis PknH receptor kinase reveals a conserved binding cleft.
Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo.
Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
Characterization of a Mycobacterium tuberculosis ESX-3 conditional mutant: essentiality and rescue by iron and zinc.
Global analysis of the Mycobacterium tuberculosis Zur (FurB) regulon.
IdeR, an essential gene in Mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.
The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis.
Base excision and nucleotide excision repair pathways in mycobacteria.
Novel DNA glycosylases from Mycobacterium tuberculosis.
The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts.
Identification of operator sites within the upstream region of the putative mce2R gene from mycobacteria.
Mce2R from Mycobacterium tuberculosis represses the expression of the mce2 operon.
A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis.
A novel role of the PrpR as a transcription factor involved in the regulation of methylcitrate pathway in Mycobacterium tuberculosis.
Role of the transcriptional regulator RamB (Rv0465c) in the control of the glyoxylate cycle in Mycobacterium tuberculosis.
Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria.
Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice.
Advance in research on Mycobacterium tuberculosis FabG4 and its inhibitor.
Crystal structure of FabG4 from Mycobacterium tuberculosis reveals the importance of C-terminal residues in ketoreductase activity.
Crystal structure of hexanoyl-CoA bound to beta-ketoacyl reductase FabG4 of Mycobacterium tuberculosis.
Crystallization and preliminary X-ray diffraction analysis of the high molecular weight ketoacyl reductase FabG4 complexed with NADH.
Design, synthesis and characterization of novel inhibitors against mycobacterial beta-ketoacyl CoA reductase FabG4.
Inhibition of M. tuberculosis beta-ketoacyl CoA reductase FabG4 (Rv0242c) by triazole linked polyphenol-aminobenzene hybrids: comparison with the corresponding gallate counterparts.
The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2.
Expression, purification, crystallization and preliminary X-ray analysis of the acyl carrier protein synthase (acpS) from Mycobacterium tuberculosis.
Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations.
Structure-function analysis of the acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis.
The nonredundant roles of two 4'-phosphopantetheinyl transferases in vital processes of Mycobacteria.
A comparative biochemical and structural analysis of the intracellular chorismate mutase (Rv0948c) from Mycobacterium tuberculosis H(37)R(v) and the secreted chorismate mutase (y2828) from Yersinia pestis.
Purified recombinant hypothetical protein coded by open reading frame Rv1885c of Mycobacterium tuberculosis exhibits a monofunctional AroQ class of periplasmic chorismate mutase activity.
Characterization of FtsY, its interaction with Ffh, and proteomic identification of their potential substrates in Mycobacterium tuberculosis.
Essential biochemical, biophysical and computational inputs on efficient functioning of Mycobacterium tuberculosis H37Rv FtsY.
Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis.
Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains.
Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis.
Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism.
PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5.
Broad substrate stereospecificity of the Mycobacterium tuberculosis 7-keto-8-aminopelargonic acid synthase: Spectroscopic and kinetic studies.
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase.
Crystal structure of full-length Mycobacterium tuberculosis H37Rv glycogen branching enzyme: insights of N-terminal beta-sandwich in substrate specificity and enzymatic activity.
Expression and characterization of alpha-(1,4)-glucan branching enzyme Rv1326c of Mycobacterium tuberculosis H37Rv.
Redox biology of Mycobacterium tuberculosis H37Rv: protein-protein interaction between GlgB and WhiB1 involves exchange of thiol-disulfide.
jefA (Rv2459), a drug efflux gene in Mycobacterium tuberculosis confers resistance to isoniazid & ethambutol.
Atypical OmpR/PhoB subfamily response regulator GlnR of actinomycetes functions as a homodimer, stabilized by the unphosphorylated conserved Asp-focused charge interactions.
Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria.
IpdAB, a virulence factor in Mycobacterium tuberculosis, is a cholesterol ring-cleaving hydrolase.
Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners.
Proteomic profiling of Mycobacterium tuberculosis identifies nutrient-starvation-responsive toxin-antitoxin systems.
A genetic locus required for iron acquisition in Mycobacterium tuberculosis.
Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis.
Identification of a short (C15) chain Z-isoprenyl diphosphate synthase and a homologous long (C50) chain isoprenyl diphosphate synthase in Mycobacterium tuberculosis.
Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.
The structural basis of chain length control in Rv1086.
Mycobacterium tuberculosis PE13 (Rv1195) manipulates the host cell fate via p38-ERK-NF-kappaB axis and apoptosis.
Identification of a copper-binding metallothionein in pathogenic mycobacteria.
Lipoprotein LpqS deficient M. tuberculosis mutant is attenuated for virulence in vivo and shows protective efficacy better than BCG in guinea pigs.
The lpqS knockout mutant of Mycobacterium tuberculosis is attenuated in macrophages.
Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA.
EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity.
EspD is critical for the virulence-mediating ESX-1 secretion system in Mycobacterium tuberculosis.
EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the two-component systems MprAB and PhoPR.
Long-range transcriptional control of an operon necessary for virulence-critical ESX-1 secretion in Mycobacterium tuberculosis.
M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells.
MprAB regulates the espA operon in Mycobacterium tuberculosis and modulates ESX-1 function and host cytokine response.
Mutually dependent secretion of proteins required for mycobacterial virulence.
Mycobacterium tuberculosis differentially activates cGAS- and inflammasome-dependent intracellular immune responses through ESX-1.
Phenotypic profiling of Mycobacterium tuberculosis EspA point mutants reveals that blockage of ESAT-6 and CFP-10 secretion in vitro does not always correlate with attenuation of virulence.
Secreted transcription factor controls Mycobacterium tuberculosis virulence.
The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis.
Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules.
Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibit mycobacterial growth and are expressed in infected human macrophages.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of tetrahydrodipicolinate-N-succinyltransferase (Rv1201c) from Mycobacterium tuberculosis.
The three-dimensional structure of a mycobacterial DapD provides insights into DapD diversity and reveals unexpected particulars about the enzymatic mechanism.
Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis. Crystal structures of the enzyme alpha-aminoacrylate intermediate and an enzyme-inhibitor complex.
Identification of acidic, low molecular mass proteins of Mycobacterium tuberculosis strain H37Rv by matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry.
The mycosins of Mycobacterium tuberculosis H37Rv: a family of subtilisin-like serine proteases.
Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli.
Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action.
Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.
para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis.
Gene expression profiling analysis of Mycobacterium tuberculosis genes in response to salicylate.
The promoter of Rv0560c is induced by salicylate and structurally-related compounds in Mycobacterium tuberculosis.
Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions.
The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases.
The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction.
A newly identified 191A/C mutation in the Rv2629 gene that was significantly associated with rifampin resistance in Mycobacterium tuberculosis.
Comparative proteome analysis of Mycobacterium tuberculosis grown under aerobic and anaerobic conditions.
Rifampin resistance, Beijing-W clade-single nucleotide polymorphism cluster group 2 phylogeny, and the Rv2629 191-C allele in Mycobacterium tuberculosis strains.
Development of an unbiased antigen-mining approach to identify novel vaccine antigens and diagnostic reagents for bovine tuberculosis.
Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene.
Ergothioneine maintains redox and bioenergetic homeostasis essential for drug susceptibility and virulence of Mycobacterium tuberculosis.
Mycobacterium tuberculosis WhiB3 responds to vacuolar pH-induced changes in mycothiol redox potential to modulate phagosomal maturation and virulence.
The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).
A nickel-cobalt-sensing ArsR-SmtB family repressor. Contributions of cytosol and effector binding sites to metal selectivity.
Solution structure of Mycobacterium tuberculosis NmtR in the apo state: insights into Ni(II)-mediated allostery.
All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis.
An ArsR-like transcriptional factor recognizes a conserved sequence motif and positively regulates the expression of phoP in mycobacteria.
Characterization of a novel ArsR-like regulator encoded by Rv2034 in Mycobacterium tuberculosis.
Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.
Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
A TyrCD1/TrpG8 hydrogen bond network and a TyrB10TyrCD1 covalent link shape the heme distal site of Mycobacterium tuberculosis hemoglobin O.
Mycobacterium tuberculosis hemoglobin HbO associates with membranes and stimulates cellular respiration of recombinant Escherichia coli.
Novel role of phosphorylation-dependent interaction between FtsZ and FipA in mycobacterial cell division.
MMAS-1, the branch point between cis- and trans-cyclopropane-containing oxygenated mycolates in Mycobacterium tuberculosis.
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.
Crystal structure of the iron-dependent regulator (IdeR) from Mycobacterium tuberculosis shows both metal binding sites fully occupied.
The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages.
The evolution of SMC proteins: phylogenetic analysis and structural implications.
Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment.
Mycobacterium tuberculosis Hip1 dampens macrophage proinflammatory responses by limiting toll-like receptor 2 activation.
Mycobacterium tuberculosis Rv2224c modulates innate immune responses.
Mycobacterium tuberculosis impairs dendritic cell functions through the serine hydrolase Hip1.
Small-molecule probes reveal esterases with persistent activity in dormant and reactivating Mycobacterium tuberculosis.
Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).
Mycobacterium tuberculosis rv1400c encodes functional lipase/esterase.
Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase.
Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects.
Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis.
The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis.
The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions.
A new family of type III polyketide synthases in Mycobacterium tuberculosis.
A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites.
Promiscuous fatty acyl CoA ligases produce acyl-CoA and acyl-SNAC precursors for polyketide biosynthesis.
Characterization of a bifunctional beta-lactamase/ribonuclease and its interaction with a chaperone-like protein in the pathogen Mycobacterium tuberculosis H37Rv.
Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis.
A protein linkage map of the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis.
The ABC transporter Rv1272c of Mycobacterium tuberculosis enhances the import of long-chain fatty acids in Escherichia coli.
ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases.
Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier.
Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice.
Crystallization and preliminary X-ray crystallographic studies of the N-terminal domain of FadD28, a fatty-acyl AMP ligase from Mycobacterium tuberculosis.
Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria.
Expanding the chemical diversity of natural esters by engineering a polyketide-derived pathway into Escherichia coli.
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling.
Molecular basis of the functional divergence of fatty acyl-AMP ligase biosynthetic enzymes of Mycobacterium tuberculosis.
Functional analysis of the Mycobacterium tuberculosis MprAB two-component signal transduction system.
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
Mycobacterium tuberculosis signal transduction system required for persistent infections.
Cloning and sequencing of a unique antigen MPT70 from Mycobacterium tuberculosis H37Rv and expression in BCG using E. coli-mycobacteria shuttle vector.
Structural basis for the regulation of the MmpL transporters of Mycobacterium tuberculosis.
Transcription regulation by the Mycobacterium tuberculosis alternative sigma factor SigD and its role in virulence.
Identification of Rv3230c as the NADPH oxidoreductase of a two-protein DesA3 acyl-CoA desaturase in Mycobacterium tuberculosis H37Rv.
An M. tuberculosis DNA fragment contains genes encoding cell division proteins ftsX and ftsE, a basic protein and homologues of PemK and small protein B.
Mycobacterium tuberculosis possesses an unusual tmRNA rescue system.
Amino acids allosterically regulate the thiamine diphosphate-dependent alpha-keto acid decarboxylase from Mycobacterium tuberculosis.
Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic-type serine/threonine kinase from Mycobacterium tuberculosis.
Phosphorylation of Mycobacterium tuberculosis Ser/Thr phosphatase by PknA and PknB.
Phosphorylation regulates mycobacterial proteasome.
PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activity.
Protein kinase A (PknA) of Mycobacterium tuberculosis is independently activated and is critical for growth in vitro and survival of the pathogen in the host.
Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria.
The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.
The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.
The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization.
Polyphosphate kinase 2: a modulator of nucleoside diphosphate kinase activity in mycobacteria.
Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.
An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis.
An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis.
Functional plasticity and allosteric regulation of alpha-ketoglutarate decarboxylase in central mycobacterial metabolism.
Regulation of glutamate metabolism by protein kinases in mycobacteria.
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase.
Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis.
A mycobacterial extracytoplasmic function sigma factor involved in survival following stress.
Evidence of complex transcriptional, translational, and posttranslational regulation of the extracytoplasmic function sigma factor sigmaE in Mycobacterium tuberculosis.
Mycobacterium tuberculosis sigma factor E regulon modulates the host inflammatory response.
RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis.
The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice.
Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1beta immune pathway.
Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival.
The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defence.
Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis.
Mechanistic insights into a novel exporter-importer system of Mycobacterium tuberculosis unravel its role in trafficking of iron.
The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain.
Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.
M. tuberculosis Ser/Thr protein kinase D phosphorylates an anti-anti-sigma factor homolog.
Stress response of genes encoding putative stress signaling molecules of Mycobacterium tuberculosis.
Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) protein domains target LipY lipases of pathogenic mycobacteria to the cell surface via the ESX-5 pathway.
Delineating the physiological roles of the PE and catalytic domains of LipY in lipid consumption in Mycobacterium-infected foamy macrophages.
Dissecting the membrane lipid binding properties and lipase activity of Mycobacterium tuberculosis LipY domains.
Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY.
Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia.
Identification and characterization of lipase activity and immunogenicity of LipL from Mycobacterium tuberculosis.
Increased virulence of Mycobacterium tuberculosis H37Rv overexpressing LipY in a murine model.
Modulation of the activity of Mycobacterium tuberculosis LipY by its PE domain.
Type VII secretion substrates of pathogenic Mycobacteria are processed by a surface protease.
Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.
Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.
Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth.
Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms.
Sigma factor F does not prevent rifampin inhibition of RNA polymerase or cause rifampin tolerance in Mycobacterium tuberculosis.
The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster.
Differential B-cell responses are induced by Mycobacterium tuberculosis PE antigens Rv1169c, Rv0978c, and Rv1818c.
Down-regulation of PE11, a cell wall associated esterase, enhances the biofilm growth of Mycobacterium tuberculosis and reduces cell wall virulence lipid levels.
PE11 (Rv1169c) selectively alters fatty acid components of Mycobacterium smegmatis and host cell interleukin-6 level accompanied with cell death.
PE11, a PE/PPE family protein of Mycobacterium tuberculosis is involved in cell wall remodeling and virulence.
The PPE domain of PPE17 is responsible for its surface localization and can be used to express heterologous proteins on the mycobacterial surface.
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase.
Structural views of quinone oxidoreductase from Mycobacterium tuberculosis reveal large conformational changes induced by the co-factor.
Structural views of quinone oxidoreductase from Mycobacteriumtuberculosis reveal large conformational changes induced by the co-factor.
A preclinical candidate targeting Mycobacterium tuberculosis KasA.
Crystal structures of Mycobacterium tuberculosis KasA show mode of action within cell wall biosynthesis and its inhibition by thiolactomycin.
Exploring the SAR of the beta-ketoacyl-ACP synthase inhibitor GSK3011724A and optimization around a genotoxic metabolite.
Identification of KasA as the cellular target of an anti-tubercular scaffold.
KasA, another brick in the mycobacterial cell wall.
Molecular dynamics of Mycobacterium tuberculosis KasA: implications for inhibitor and substrate binding and consequences for drug design.
Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.
Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB.
Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis.
Substrate recognition by beta-ketoacyl-ACP synthases.
The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.
The protonation state of catalytic residues in the resting state of KasA revisited: detailed mechanism for the activation of KasA by its own substrate.
The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis.
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis.
Structural analysis of mycobacterial branched-chain aminotransferase: implications for inhibitor design.
The 1.9 A structure of the branched-chain amino-acid transaminase (IlvE) from Mycobacterium tuberculosis.
A Mycobacterium tuberculosis sigma factor network responds to cell-envelope damage by the promising anti-mycobacterial thioridazine.
ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage.
ClpR protein-like regulator specifically recognizes RecA protein-independent promoter motif and broadly regulates expression of DNA damage-inducible genes in mycobacteria.
Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities.
Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture.
Novel role of Wag31 in protection of mycobacteria under oxidative stress.
AcpM, the meromycolate extension acyl carrier protein of Mycobacterium tuberculosis, is activated by the 4'-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis.
Structural studies on Mycobacterium tuberculosis HddA enzyme using small angle X-ray scattering and dynamics simulation techniques.
Molecular characterization of MPT83: a seroreactive antigen of Mycobacterium tuberculosis with homology to MPT70.
Recombinant MPT83 derived from Mycobacterium tuberculosis induces cytokine production and upregulates the function of mouse macrophages through TLR2.
The secreted lipoprotein, MPT83, of Mycobacterium tuberculosis is recognized during human tuberculosis and stimulates protective immunity in mice.
Crystal structure of the transcription elongation/anti-termination factor NusA from Mycobacterium tuberculosis at 1.7 A resolution.
Structure of a Mycobacterium tuberculosis NusA-RNA complex.
AccD6, a member of the Fas II locus, is a functional carboxyltransferase subunit of the acyl-coenzyme A carboxylase in Mycobacterium tuberculosis.
High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme.
Identification and characterization of a unique adenosine kinase from Mycobacterium tuberculosis.
Overexpression, purification and crystallographic analysis of a unique adenosine kinase from Mycobacterium tuberculosis.
Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(het)aryl-7-deazaadenine ribonucleosides.
A novel two-component system found in Mycobacterium tuberculosis.
Cyclic di-GMP sensing histidine kinase PdtaS controls mycobacterial adaptation to carbon sources.
Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls M. tuberculosis acute lung infection.
The sensor region of the ubiquitous cytosolic sensor kinase, PdtaS, contains PAS and GAF domain sensing modules.
The hydrolase LpqI primes mycobacterial peptidoglycan recycling.
A stationary-phase stress-response sigma factor from Mycobacterium tuberculosis.
Genome-wide definition of the SigF regulon in Mycobacterium tuberculosis.
Interactions of the M. tuberculosis UsfX with the cognate sigma factor SigF and the anti-anti sigma factor RsfA.
Over-expression and purification strategies for recombinant multi-protein oligomers: a case study of Mycobacterium tuberculosis sigma/anti-sigma factor protein complexes.
Cloning, overexpression, purification, crystallization and preliminary X-ray diffraction analysis of Rv0241c (HtdX) from Mycobacterium tuberculosis H37Rv.
Heterologous expression of mycobacterial proteins in Saccharomyces cerevisiae reveals two physiologically functional 3-hydroxyacyl-thioester dehydratases, HtdX and HtdY, in addition to HadABC and HtdZ.
Revisiting the assignment of Rv0241c to fatty acid synthase type II of Mycobacterium tuberculosis.
Expression, characterization and subcellular localization of the Mycobacterium tuberculosis PPE gene Rv1917c.
Src homology 3-interacting domain of Rv1917c of Mycobacterium tuberculosis induces selective maturation of human dendritic cells by regulating PI3K-MAPK-NF-kappaB signaling and drives Th2 immune responses.
Nonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetases.
Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system.
C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis.
Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis.
Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria.
Substrates control multimerization and activation of the multi-domain ATPase motor of type VII secretion.
The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue.
Mycobacterium tuberculosis utilizes a unique heterotetrameric structure for dehydrogenation of the cholesterol side chain.
Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism.
Unraveling cholesterol catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 alpha2beta2 acyl-CoA dehydrogenase initiates beta-oxidation of 3-oxo-cholest-4-en-26-oyl CoA.
Kinetic, thermodynamic, and structural insight into the mechanism of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis.
Structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation.
Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase.
X-ray study of the conformational changes in the molecule of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis during the catalyzed reaction.
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.
Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis.
A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis.
Characterization of Mycobacterium tuberculosis NAD kinase: functional analysis of the full-length enzyme by site-directed mutagenesis.
Crystallization and preliminary X-ray analysis of NAD kinase from Mycobacterium tuberculosis H37Rv.
Crystallographic studies of Mycobacterium tuberculosis polyphosphate/ATP-NAD kinase complexed with NAD.
Inorganic polyphosphate / ATP-NAD kinase of Micrococcus flavus and Mycobacterium tuberculosis H37Rv.
NAD-binding mode and the significance of intersubunit contact revealed by the crystal structure of Mycobacterium tuberculosis NAD kinase-NAD complex.
Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis.
A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapA (Rv2753c) from Mycobacterium tuberculosis.
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.
Mycobacterium tuberculosis possesses a functional enzyme for the synthesis of vitamin C, L-gulono-1,4-lactone dehydrogenase.
Co-induction of methyltransferase Rv0560c by naphthoquinones and fibric acids suggests attenuation of isoprenoid quinone action in Mycobacterium tuberculosis.
Modification of the Pseudomonas aeruginosa toxin 2-heptyl-1-hydroxyquinolin-4(1H)-one and other secondary metabolites by methyltransferases from mycobacteria.
Mycobacterium tuberculosis Rv0560c is not essential for growth in vitro or in macrophages.
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
The inhibitory effect of GlmU acetyltransferase inhibitor TPSA on Mycobacterium tuberculosis may be affected due to its methylation by methyltransferase Rv0560c.
A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.
Mycobacterium tuberculosis serine/threonine kinases PknB, PknD, PknE, and PknF phosphorylate multiple FHA domains.
Structural and functional analysis of phosphothreonine-dependent FHA domain interactions.
Structural insight into the Mycobacterium tuberculosis Rv0020c protein and its interaction with the PknB kinase.
Interaction between FtsW and penicillin-binding protein 3 (PBP3) directs PBP3 to mid-cell, controls cell septation and mediates the formation of a trimeric complex involving FtsZ, FtsW and PBP3 in mycobacteria.
Interaction between FtsZ and FtsW of Mycobacterium tuberculosis.
Characterization of T-cell immunogenicity of two PE/PPE proteins of Mycobacterium tuberculosis.
Identification of the Mycobacterium tuberculosis protein PE-PGRS62 as a novel effector that functions to block phagosome maturation and inhibit iNOS expression.
Mycobacterium tuberculosis cell wall-associated Rv3812 protein induces strong dendritic cell-mediated interferon gamma responses and exhibits vaccine potential.
PE_PGRS62 promotes the survival of Mycobacterium smegmatis within macrophages via disrupting ER stress-mediated apoptosis.
The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg(2+) ion in the active site and a putative RNA-binding Site.
RecX protein abrogates ATP hydrolysis and strand exchange promoted by RecA: insights into negative regulation of homologous recombination.
Cloning of the dapB gene, encoding dihydrodipicolinate reductase, from Mycobacterium tuberculosis.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapB (Rv2773c) from Mycobacterium tuberculosis.
The structure of dihydrodipicolinate reductase (DapB) from Mycobacterium tuberculosis in three crystal forms.
The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity.
Engineering a change in metal-ion specificity of the iron-dependent superoxide dismutase from Mycobacterium tuberculosis -X-ray structure analysis of site-directed mutants.
Engineering of an intersubunit disulfide bridge in the iron-superoxide dismutase of Mycobacterium tuberculosis.
Export of recombinant Mycobacterium tuberculosis superoxide dismutase is dependent upon both information in the protein and mycobacterial export machinery. A model for studying export of leaderless proteins by pathogenic mycobacteria.
Genetic analysis of superoxide dismutase, the 23 kilodalton antigen of Mycobacterium tuberculosis.
X-ray structure analysis of an engineered Fe-superoxide dismutase Gly-Ala mutant with significantly reduced stability to denaturant.
X-ray structure analysis of the iron-dependent superoxide dismutase from Mycobacterium tuberculosis at 2.0-A resolution reveals novel dimer-dimer interactions.
Characterization of acetohydroxyacid synthase from Mycobacterium tuberculosis and the identification of its new inhibitor from the screening of a chemical library.
In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria.
Inactivation of the ilvB1 gene in Mycobacterium tuberculosis leads to branched-chain amino acid auxotrophy and attenuation of virulence in mice.
Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I.
Mycobacterium tuberculosis efpA encodes an efflux protein of the QacA transporter family.
Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-10/ESAT-6 protein family: towards an understanding of the rules governing complex formation and thereby functional flexibility.
The crystal structure of the Mycobacterium tuberculosis Rv3019c-Rv3020c ESX complex reveals a domain-swapped heterotetramer.
Cloning, expression and significance of MPT53 for identification of secreted proteins of Mycobacterium tuberculosis.
Gram-positive DsbE proteins function differently from Gram-negative DsbE homologs. A structure to function analysis of DsbE from Mycobacterium tuberculosis.
The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor.
Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor.
Overexpression, purification and biochemical characterization of a class A high-molecular-mass penicillin-binding protein (PBP), PBP1* and its soluble derivative from Mycobacterium tuberculosis.
Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis.
Cloning and characterization of the aroA gene from Mycobacterium tuberculosis.
Cloning and overexpression in soluble form of functional shikimate kinase and 5-enolpyruvylshikimate 3-phosphate synthase enzymes from Mycobacterium tuberculosis.
Structural basis of the PE-PPE protein interaction in Mycobacterium tuberculosis.
A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis.
Biosynthesis and regulation of sulfomenaquinone, a metabolite associated with virulence in Mycobacterium tuberculosis.
Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis.
Sulfotransferases and sulfatases in mycobacteria.
Expression and characterization of the protein Rv1399c from Mycobacterium tuberculosis. A novel carboxyl esterase structurally related to the HSL family.
Mycobacterial and Human Nitrobindins: Structure and Function.
A novel firefly luciferase biosensor enhances the detection of apoptosis induced by ESAT-6 family proteins of Mycobacterium tuberculosis.
Biophysical and immunological characterization of the ESX-4 system ESAT-6 family proteins Rv3444c and Rv3445c from Mycobacterium tuberculosis H37Rv.
Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure.
Biochemical and biophysical characterization of nucleotide binding domain of Trehalose transporter from Mycobacterium tuberculosis.
Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis.
Composition of the type VII secretion system membrane complex.
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.
Cloning of the lysA gene from Mycobacterium tuberculosis.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of LysA (Rv1293) from Mycobacterium tuberculosis.
Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis.
The three-dimensional structure of diaminopimelate decarboxylase from Mycobacterium tuberculosis reveals a tetrameric enzyme organisation.
IpdE1-IpdE2 is a heterotetrameric acyl coenzyme A dehydrogenase that is widely distributed in steroid-degrading bacteria.
Partial saturation of menaquinone in Mycobacterium tuberculosis: function and essentiality of a novel reductase, MenJ.
Cloning and expression of an acyl-CoA dehydrogenase from Mycobacterium tuberculosis.
An NAD+ phosphorylase toxin triggers Mycobacterium tuberculosis cell death.
Co-expression network analysis of toxin-antitoxin loci in Mycobacterium tuberculosis reveals key modulators of cellular stress.
Comprehensive essentiality analysis of the Mycobacterium tuberculosis genome via saturating transposon mutagenesis.
Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival.
The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+.
The enduring hypoxic response of Mycobacterium tuberculosis.
Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis.
A family of cross-reacting proteins secreted by Mycobacterium tuberculosis.
Cloning and B-cell-epitope mapping of MPT64 from Mycobacterium tuberculosis H37Rv.
High-level heterologous expression and secretion in rapidly growing nonpathogenic mycobacteria of four major Mycobacterium tuberculosis extracellular proteins considered to be leading vaccine candidates and drug targets.
Structural and functional characterization of the transcriptional regulator Rv3488 of Mycobacterium tuberculosis H37Rv.
A revised biosynthetic pathway for the cofactor F420 in prokaryotes.
An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice.
Forkhead-associated (FHA) domain containing ABC transporter Rv1747 is positively regulated by Ser/Thr phosphorylation in Mycobacterium tuberculosis.
Two FHA domains on an ABC transporter, Rv1747, mediate its phosphorylation by PknF, a Ser/Thr protein kinase from Mycobacterium tuberculosis.
Crystal structure of DNA polymerase III beta sliding clamp from Mycobacterium tuberculosis.
Activation of the pro-drug ethionamide is regulated in mycobacteria.
Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistance.
Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis.
Synthetic EthR inhibitors boost antituberculous activity of ethionamide.
Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF.
Inhibition of the plasma-membrane-associated serine protease cathepsin G by Mycobacterium tuberculosis Rv3364c suppresses caspase-1 and pyroptosis in macrophages.
Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis.
Structure-function analysis of VapB4 antitoxin identifies critical features of a minimal VapC4 toxin-binding module.
Actinobacterial acyl coenzyme A synthetases involved in steroid side-chain catabolism.
A novel F(420)-dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents.
Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics.
Cyclic GMP-AMP synthase is an innate immune DNA sensor for Mycobacterium tuberculosis.
Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Mycobacterium tuberculosis PE_PGRS17 promotes the death of host cell and cytokines secretion via Erk kinase accompanying with enhanced survival of recombinant Mycobacterium smegmatis.
The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase.
Rv2131c from Mycobacterium tuberculosis is a CysQ 3'-phosphoadenosine-5'-phosphatase.
Rv2131c gene product: an unconventional enzyme that is both inositol monophosphatase and fructose-1,6-bisphosphatase.
A tethering mechanism for length control in a processive carbohydrate polymerization.
Biosynthesis of the galactan component of the mycobacterial cell wall.
Development of a coupled spectrophotometric assay for GlfT2, a bifunctional mycobacterial galactofuranosyltransferase.
Expression, purification, and characterization of a galactofuranosyltransferase involved in Mycobacterium tuberculosis arabinogalactan biosynthesis.
Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase.
Galactosyl transferases in mycobacterial cell wall synthesis.
Tetrameric structure of the GlfT2 galactofuranosyltransferase reveals a scaffold for the assembly of mycobacterial arabinogalactan.
Overexpression, purification, crystallization and preliminary X-ray analysis of putative molybdenum cofactor biosynthesis protein C (MoaC2) from Mycobacterium tuberculosis H37Rv.
Crystal structure of ArgP from Mycobacterium tuberculosis confirms two distinct conformations of full-length LysR transcriptional regulators and reveals its function in DNA binding and transcriptional regulation.
Mycobacterium tuberculosis region of difference (RD) 2 antigen Rv1985c and RD11 antigen Rv3425 have the promising potential to distinguish patients with active tuberculosis from M. bovis BCG-vaccinated individuals.
The transcriptional regulator LysG (Rv1985c) of Mycobacterium tuberculosis activates lysE (Rv1986) in a lysine-dependent manner.
Identification of a novel peptidoglycan hydrolase CwlM in Mycobacterium tuberculosis.
A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin.
Analyzing the catalytic mechanism of MPtpA: a low molecular weight protein tyrosine phosphatase from Mycobacterium tuberculosis through site-directed mutagenesis.
Backbone NMR assignment of the low-molecular-weight protein tyrosine phosphatase (MPtpA) from Mycobacterium tuberculosis.
Cloning and characterization of secretory tyrosine phosphatases of Mycobacterium tuberculosis.
Crystal structure of low-molecular-weight protein tyrosine phosphatase from Mycobacterium tuberculosis at 1.9-A resolution.
Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach.
Expression and localization of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.
Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA.
Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3alpha.
Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification.
Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system.
Mycobacterium tuberculosis tyrosine phosphatase A (PtpA) activity is modulated by S-nitrosylation.
Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B.
Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development.
New potential eukaryotic substrates of the mycobacterial protein tyrosine phosphatase PtpA: hints of a bacterial modulation of macrophage bioenergetics state.
Phosphorylation control of protein tyrosine phosphatase A activity in Mycobacterium tuberculosis.
Protein tyrosine phosphatase PtpA is not required for Mycobacterium tuberculosis growth in mice.
S-nitrosylation of Mycobacterium tuberculosis tyrosine phosphatase A (PtpA) induces its structural instability.
Substrate activation of the low-molecular weight protein tyrosine phosphatase from Mycobacterium tuberculosis.
Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB).
The apo-structure of the low molecular weight protein-tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development.
The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation.
The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by Mycobacterium tuberculosis PtpA during mycobacterial infection.
Tyrosine phosphatase MptpA of Mycobacterium tuberculosis inhibits phagocytosis and increases actin polymerization in macrophages.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapC (Rv0858c) from Mycobacterium tuberculosis.
The three-dimensional structure of N-succinyldiaminopimelate aminotransferase from Mycobacterium tuberculosis.
Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.
Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2.
Cytokinin Signaling in Mycobacterium tuberculosis.
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.
Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis.
Lsr2 of Mycobacterium tuberculosis is a DNA-bridging protein.
Mycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulence.
Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins.
The multifunctional histone-like protein Lsr2 protects mycobacteria against reactive oxygen intermediates.
The structure of the oligomerization domain of Lsr2 from Mycobacterium tuberculosis reveals a mechanism for chromosome organization and protection.
Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis.
Profiling of Mycobacterium tuberculosis gene expression during human macrophage infection: upregulation of the alternative sigma factor G, a group of transcriptional regulators, and proteins with unknown function.
SigG does not control gene expression in response to DNA damage in Mycobacterium tuberculosis H37Rv.
Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes.
Characterization of the proteasome accessory factor (paf) operon in Mycobacterium tuberculosis.
Identification of substrates of the Mycobacterium tuberculosis proteasome.
Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis.
Prokaryotic ubiquitin-like protein (Pup) is coupled to substrates via the side chain of its C-terminal glutamate.
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide.
Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis.
Crystal structure of Mycobacterium tuberculosis YefM antitoxin reveals that it is not an intrinsically unstructured protein.
The three RelE homologs of Mycobacterium tuberculosis have individual, drug-specific effects on bacterial antibiotic tolerance.
Dual phosphorylation in response regulator protein PrrA is crucial for intracellular survival of mycobacteria consequent upon transcriptional activation.
Intracellular autoregulation of the Mycobacterium tuberculosis PrrA response regulator.
The prrAB two-component system is essential for Mycobacterium tuberculosis viability and is induced under nitrogen-limiting conditions.
Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis.
Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis.
Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin.
Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis.
Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI).
Roles of trpE2, entC and entD in salicylic acid biosynthesis in Mycobacterium smegmatis.
Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis.
The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase.
Important role for Mycobacterium tuberculosis UvrD1 in pathogenesis and persistence apart from its function in nucleotide excision repair.
Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and noncognate RecA proteins.
Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery.
FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation.
Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.
CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.
CtpV: a putative copper exporter required for full virulence of Mycobacterium tuberculosis.
Identification of Mycobacterium tuberculosis H37Rv integral membrane proteins by one-dimensional gel electrophoresis and liquid chromatography electrospray ionization tandem mass spectrometry.
The crystal structure of NusB from Mycobacterium tuberculosis.
Cloning and characterization of aspartate-beta-semialdehyde dehydrogenase from Mycobacterium tuberculosis H37 Rv.
Identification and validation of aspartic acid semialdehyde dehydrogenase as a new anti-Mycobacterium tuberculosis target.
Molecular modelling and comparative structural account of aspartyl beta-semialdehyde dehydrogenase of Mycobacterium tuberculosis (H37Rv).
Pharmacoinformatics analysis to identify inhibitors of Mtb-ASADH.
Purification, crystallization and preliminary X-ray diffraction analysis of aspartate semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis.
Shape-based virtual screening, docking, and molecular dynamics simulations to identify Mtb-ASADH inhibitors.
Structures of ternary complexes of aspartate-semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis H37Rv.
Rv1288, a two domain, cell wall anchored, nutrient stress inducible carboxyl-esterase of Mycobacterium tuberculosis, modulates cell wall lipid.
Biochemical investigation of Rv3404c from Mycobacterium tuberculosis.
Characterization of a Mycobacterium tuberculosis H37Rv transposon library reveals insertions in 351 ORFs and mutants with altered virulence.
Identification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis.
Identification of Rv0535 as methylthioadenosine phosphorylase from Mycobacterium tuberculosis.
Further insight into S-adenosylmethionine-dependent methyltransferases: structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis.
Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis.
Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.
Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice.
Tracking the putative biosynthetic precursors of oxygenated mycolates of Mycobacterium tuberculosis. Structural analysis of fatty acids of a mutant strain deviod of methoxy- and ketomycolates.
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.
Solution structure and refolding of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA.
Stability, denaturation and refolding of Mycobacterium tuberculosis MfpA, a DNA mimicking protein that confers antibiotic resistance.
Molecular cloning of the leuB genes from Mycobacterium bovis BCG and Mycobacterium tuberculosis.
The high-resolution Structure of LeuB (Rv2995c) from Mycobacterium tuberculosis.
The mRNA interferases, MazF-mt3 and MazF-mt7 from Mycobacterium tuberculosis target unique pentad sequences in single-stranded RNA.
A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems.
Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance.
Discovery and characterization of a unique mycobacterial heme acquisition system.
MmpL11 protein transports mycolic acid-containing lipids to the mycobacterial cell wall and contributes to biofilm formation in Mycobacterium smegmatis.
The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11.
A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor.
Characterization of Mycobacterium tuberculosis WhiB1/Rv3219 as a protein disulfide reductase.
Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins.
Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster.
Mycobacterium tuberculosis cAMP receptor protein (Rv3676) differs from the Escherichia coli paradigm in its cAMP binding and DNA binding properties and transcription activation properties.
Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1.
Studies on structural and functional divergence among seven WhiB proteins of Mycobacterium tuberculosis H37Rv.
Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis.
The ATP binding cassette (ABC) transport systems of Mycobacterium tuberculosis.
The expression of ABC efflux pump, Rv1217c-Rv1218c, and its association with multidrug resistance of Mycobacterium tuberculosis in China.
Kinetic and mechanistic characterization of the glyceraldehyde 3-phosphate dehydrogenase from Mycobacterium tuberculosis.
Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv.
Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase.
Post-translational Succinylation of Mycobacterium tuberculosis Enoyl-CoA Hydratase EchA19 Slows Catalytic Hydration of Cholesterol Catabolite 3-Oxo-chol-4,22-diene-24-oyl-CoA.
Succinylome analysis reveals the involvement of lysine succinylation in metabolism in pathogenic Mycobacterium tuberculosis.
DNA-dependent ATPase activity of bacterial XPB helicases.
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB.
A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.
FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosis.
Mycobacterium tuberculosis Rv2179c establishes a new exoribonuclease family with broad phylogenetic distribution.
A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties.
Bacterial glycoproteins: a link between glycosylation and proteolytic cleavage of a 19 kDa antigen from Mycobacterium tuberculosis.
Effect of deletion or overexpression of the 19-kilodalton lipoprotein Rv3763 on the innate response to Mycobacterium tuberculosis.
Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors.
Lipoprotein access to MHC class I presentation during infection of murine macrophages with live mycobacteria.
Lipoprotein antigens of Mycobacterium tuberculosis.
Lipoproteins of slow-growing Mycobacteria carry three fatty acids and are N-acylated by apolipoprotein N-acyltransferase BCG_2070c.
Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2.
Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.
Mycobacterium tuberculosis 19-kDa lipoprotein induces Toll-like receptor 2-dependent peroxisome proliferator-activated receptor gamma expression and promotes inflammatory responses in human macrophages.
Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2.
Nucleotide sequence of the 19 kDa antigen gene from Mycobacterium tuberculosis.
PstS-1, the 38-kDa Mycobacterium tuberculosis glycoprotein, is an adhesin, which binds the macrophage mannose receptor and promotes phagocytosis.
Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors.
Stress proteins are immune targets in leprosy and tuberculosis.
The 19 kDa Mycobacterium tuberculosis lipoprotein (LpqH) induces macrophage apoptosis through extrinsic and intrinsic pathways: a role for the mitochondrial apoptosis-inducing factor.
The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through Toll-like receptor-2.
The 19-kDa antigen of Mycobacterium tuberculosis is a major adhesin that binds the mannose receptor of THP-1 monocytic cells and promotes phagocytosis of mycobacteria.
The Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits gamma interferon-regulated HLA-DR and Fc gamma R1 on human macrophages through Toll-like receptor 2.
The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes.
Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis.
Identification and architecture of a putative secretion tube across mycobacterial outer envelope.
Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis.
Mycobacterium tuberculosis IMPDH in complexes with substrates, products and antitubercular compounds.
Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis.
Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis.
Mycobacterium tuberculosis Rv3034c regulates mTORC1 and PPAR-gamma dependant pexophagy mechanism to control redox levels in macrophages.
A variable number of tandem repeats result in polymorphic alpha-isopropylmalate synthase in Mycobacterium tuberculosis.
Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis.
Kinetic and chemical mechanism of alpha-isopropylmalate synthase from Mycobacterium tuberculosis.
Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding.
Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs.
The acid-induced operon Rv3083-Rv3089 is required for growth of Mycobacterium tuberculosis in macrophages.
mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope.
Crystal structure of a putative methyltransferase from Mycobacterium tuberculosis: misannotation of a genome clarified by protein structural analysis.
A Mycobacterium tuberculosis gene cluster encoding proteins of a phosphate transporter homologous to the Escherichia coli Pst system.
Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1.
Mycobacterium tuberculosis RsdA provides a conformational rationale for selective regulation of sigma-factor activity by proteolysis.
Cloning and characterization of a bifunctional RelA/SpoT homologue from Mycobacterium tuberculosis.
Differential regulation of opposing RelMtb activities by the aminoacylation state of a tRNA.ribosome.mRNA.RelMtb complex.
Functional regulation of the opposing (p)ppGpp synthetase/hydrolase activities of RelMtb from Mycobacterium tuberculosis.
Mycobacterial MazG is a novel NTP pyrophosphohydrolase involved in oxidative stress response.
The stringent response of Mycobacterium tuberculosis is required for long-term survival.
Characterization of Ffh of Mycobacterium tuberculosis and its interaction with 4.5S RNA.
Characterization of heme ligation properties of Rv0203, a secreted heme binding protein involved in Mycobacterium tuberculosis heme uptake.
A bacterial transcription terminator with inefficient molecular motor action but with a robust transcription termination function.
Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages.
Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase.
Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase.
Molecular function of WhiB4/Rv3681c of Mycobacterium tuberculosis H37Rv: a [4Fe-4S] cluster co-ordinating protein disulphide reductase.
Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo.
Expression and purification of a functionally active recombinant GDP-mannosyltransferase (PimA) from Mycobacterium tuberculosis H37Rv.
The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo.
Expression and characterization of Mycobacterium tuberculosis methionine aminopeptidase type 1a.
Expression and characterization of two functional methionine aminopeptidases from Mycobacterium tuberculosis H37Rv.
Structural and functional characterization of Rv2966c protein reveals an RsmD-like methyltransferase from Mycobacterium tuberculosis and the role of its N-terminal domain in target recognition.
Structural and thermodynamic characterization of a highly stable conformation of Rv2966c, a 16S rRNA methyltransferase, at low pH.
The interaction of mycobacterial protein Rv2966c with host chromatin is mediated through non-CpG methylation and histone H3/H4 binding.
Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis.
The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis.
Purification and characterization of a functionally active Mycobacterium tuberculosis prephenate dehydrogenase.
A green fluorescent protein-based assay for high-throughput ligand-binding studies of a mycobacterial biotin protein ligase.
Active site conformational changes upon reaction intermediate biotinyl-5'-AMP binding in biotin protein ligase from Mycobacterium tuberculosis.
Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis.
Crystallization and preliminary X-ray diffraction analysis of biotin acetyl-CoA carboxylase ligase (BirA) from Mycobacterium tuberculosis.
Ligand specificity of group I biotin protein ligase of Mycobacterium tuberculosis.
Structural ordering of disordered ligand-binding loops of biotin protein ligase into active conformations as a consequence of dehydration.
Targeting Mycobacterium tuberculosis biotin protein ligase (MtBPL) with nucleoside-based bisubstrate adenylation inhibitors.
Crystal structure and function of the zinc uptake regulator FurB from Mycobacterium tuberculosis.
The structure and computational analysis of Mycobacterium tuberculosis protein CitE suggest a novel enzymatic function.
Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa.
A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.
Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.
Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase.
Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein.
Mapping conformational transitions in cyclic AMP receptor protein: crystal structure and normal-mode analysis of Mycobacterium tuberculosis apo-cAMP receptor protein.
Profound asymmetry in the structure of the cAMP-free cAMP receptor protein (CRP) from Mycobacterium tuberculosis.
Solution NMR evidence for symmetry in functionally or crystallographically asymmetric homodimers.
Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein.
Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis.
Expression, autoregulation, and DNA binding properties of the Mycobacterium tuberculosis TrcR response regulator.
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
The Mycobacterium tuberculosis TrcR response regulator represses transcription of the intracellularly expressed Rv1057 gene, encoding a seven-bladed beta-propeller.
The beta-propeller gene Rv1057 of Mycobacterium tuberculosis has a complex promoter directly regulated by both the MprAB and TrcRS two-component systems.
B cells response directed against Cut4 and CFP21 lipolytic enzymes in active and latent tuberculosis infections.
Cutinase-like proteins of Mycobacterium tuberculosis: characterization of their variable enzymatic functions and active site identification.
Expression and purification of the Mycobacterium tuberculosis complex-restricted antigen CFP21 to study its immunoprophylactic potential in mouse model.
Identification of residues involved in substrate specificity and cytotoxicity of two closely related cutinases from Mycobacterium tuberculosis.
Immunological evaluation of novel Mycobacterium tuberculosis culture filtrate proteins.
Two cutinase-like proteins secreted by Mycobacterium tuberculosis show very different lipolytic activities reflecting their physiological function.
Two-dimensional electrophoresis for analysis of Mycobacterium tuberculosis culture filtrate and purification and characterization of six novel proteins.
A distinct MaoC-like enoyl-CoA hydratase architecture mediates cholesterol catabolism in Mycobacterium tuberculosis.
Characterization of an aldolase involved in cholesterol side chain degradation in Mycobacterium tuberculosis.
Mycobacterium tuberculosis exploits a heterohexameric enoyl-CoA hydratase retro-aldolase complex for cholesterol catabolism.
Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL.
Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability.
Cyclosporin A binding to Mycobacterium tuberculosis peptidyl-prolyl cis-trans isomerase A--investigation by CD, FTIR and fluorescence spectroscopy.
X-ray structure of peptidyl-prolyl cis-trans isomerase A from Mycobacterium tuberculosis.
2-Carboxyquinoxalines kill Mycobacterium tuberculosis through noncovalent inhibition of DprE1.
Biophysical and biochemical characterization of Rv3405c, a tetracycline repressor protein from Mycobacterium tuberculosis.
Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis.
Structures of native, substrate-bound and inhibited forms of Mycobacterium tuberculosis imidazoleglycerol-phosphate dehydratase.
Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid.
Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: implication in the induction of DevR target genes.
Crystal structures of the response regulator DosR from Mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activation.
DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.
Mycobacterium tuberculosis response regulators, DevR and NarL, interact in vivo and co-regulate gene expression during aerobic nitrate metabolism.
Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models.
Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis.
Structures of Mycobacterium tuberculosis DosR and DosR-DNA complex involved in gene activation during adaptation to hypoxic latency.
Target DNA stabilizes Mycobacterium tuberculosis DevR/DosR phosphorylation by the full-length oxygen sensors DevS/DosS and DosT.
The DosS-DosT/DosR mycobacterial sensor system.
The residue threonine 82 of DevR (DosR) is essential for DevR activation and function in Mycobacterium tuberculosis despite its atypical location.
Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis.
Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy.
A novel vaccine p846 encoding Rv3615c, Mtb10.4, and Rv2660c elicits robust immune response and alleviates lung injury induced by Mycobacterium infection.
Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection.
Biochemical studies on Mycobacterium tuberculosis UreG and comparative modeling reveal structural and functional conservation among the bacterial UreG family.
Biochemical and structural characterization of TesA, a major thioesterase required for outer-envelope lipid biosynthesis in Mycobacterium tuberculosis.
Interaction studies on proteins encoded by the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis.
Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility.
Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars.
Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages.
Rv3737 is required for Mycobacterium tuberculosis growth in vitro and in vivo and correlates with bacterial load and disease severity in human tuberculosis.
Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis.
X-ray structure of putative acyl-ACP desaturase DesA2 from Mycobacterium tuberculosis H37Rv.
Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.
Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ.
Understanding the role of PknJ in Mycobacterium tuberculosis: biochemical characterization and identification of novel substrate pyruvate kinase A.
Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv.
Identification of cell cycle regulators in Mycobacterium tuberculosis by inhibition of septum formation and global transcriptional analysis.
Mycobacterium tuberculosis FurA autoregulates its own expression.
Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis.
A comparative study of host response to three Mycobacterium tuberculosis PE_PGRS proteins.
Crystal structure of a putative aspartic proteinase domain of the Mycobacterium tuberculosis cell surface antigen PE_PGRS16.
Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo.
Molecular characterization of secretory proteins Rv3619c and Rv3620c from Mycobacterium tuberculosis H37Rv.
Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis.
Crystallization of a protein using dehydration without a precipitant.
Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence.
Hypoxic response of Mycobacterium tuberculosis studied by metabolic labeling and proteome analysis of cellular and extracellular proteins.
Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice.
The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis.
Increasing the structural coverage of tuberculosis drug targets.
Mycobacterial 3-hydroxyacyl-l-thioester dehydratase Y derived from Mycobacterium tuberculosis induces COX-2 expression in mouse macrophages through MAPK-NF-kappaB pathway.
Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family.
Identification of a diacylglycerol acyltransferase gene involved in accumulation of triacylglycerol in Mycobacterium tuberculosis under stress.
Massive gene duplication event among clinical isolates of the Mycobacterium tuberculosis W/Beijing family.
Characterization of the major membrane protein of virulent Mycobacterium tuberculosis.
Deletion of the Mycobacterium tuberculosis alpha-crystallin-like hspX gene causes increased bacterial growth in vivo.
Response to reactive nitrogen intermediates in Mycobacterium tuberculosis: induction of the 16-kilodalton alpha-crystallin homolog by exposure to nitric oxide donors.
Stationary phase-associated protein expression in Mycobacterium tuberculosis: function of the mycobacterial alpha-crystallin homolog.
The 14,000-molecular-weight antigen of Mycobacterium tuberculosis is related to the alpha-crystallin family of low-molecular-weight heat shock proteins.
Construction and characterization of the Mycobacterium tuberculosis sigE fadD26 unmarked double mutant as a vaccine candidate.
Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis.
Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid.
Immunogenicity and protective efficacy of the Mycobacterium tuberculosis fadD26 mutant.
Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with shikimic acid and an ATP analogue.
Crystal structure of shikimate kinase from Mycobacterium tuberculosis reveals the dynamic role of the LID domain in catalysis.
Crystallization and preliminary X-ray diffraction analysis of shikimate kinase from Mycobacterium tuberculosis in complex with MgADP.
Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase.
Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis.
Mechanism of phosphoryl transfer catalyzed by shikimate kinase from Mycobacterium tuberculosis.
Structure of shikimate kinase from Mycobacterium tuberculosis reveals the binding of shikimic acid.
Disruption of the gene homologous to mammalian Nramp1 in Mycobacterium tuberculosis does not affect virulence in mice.
Mycobacterium tuberculosis expresses a novel pH-dependent divalent cation transporter belonging to the Nramp family.
A PE_PGRS33 protein of Mycobacterium tuberculosis: an ideal target for future tuberculosis vaccine design.
Apoptosis triggered by Rv1818c, a PE family gene from Mycobacterium tuberculosis is regulated by mitochondrial intermediates in T cells.
Are the PE-PGRS proteins of Mycobacterium tuberculosis variable surface antigens?
Comparative immune response to PE and PE_PGRS antigens of Mycobacterium tuberculosis.
Execution of macrophage apoptosis by PE_PGRS33 of Mycobacterium tuberculosis is mediated by Toll-like receptor 2-dependent release of tumor necrosis factor-alpha.
Expression of Mycobacterium tuberculosis pe_pgrs33 is repressed during stationary phase and stress conditions, and its transcription is mediated by sigma factor A.
Functional dissection of protein domains involved in the immunomodulatory properties of PE_PGRS33 of Mycobacterium tuberculosis.
Functional dissection of the PE domain responsible for translocation of PE_PGRS33 across the mycobacterial cell wall.
Induction of cell death after localization to the host cell mitochondria by the Mycobacterium tuberculosis PE_PGRS33 protein.
PE is a functional domain responsible for protein translocation and localization on mycobacterial cell wall.
PE_PGRS33 contributes to Mycobacterium tuberculosis entry in macrophages through interaction with TLR2.
Rv1818c-encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structure.
The PE_PGRS proteins of Mycobacterium tuberculosis are Ca(2+) binding mediators of host-pathogen interaction.
The PGRS domain from PE_PGRS33 of Mycobacterium tuberculosis is target of humoral immune response in mice and humans.
Characterization of three glycosyltransferases involved in the biosynthesis of the phenolic glycolipid antigens from the Mycobacterium tuberculosis complex.
Interaction between polyketide synthase and transporter suggests coupled synthesis and export of virulence lipid in M. tuberculosis.
Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids.
Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue.
Gene expression profile of Mycobacterium tuberculosis in a non-replicating state.
Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis.
Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria.
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages.
O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis.
The C-terminal of CysM from Mycobacterium tuberculosis protects the aminoacrylate intermediate and is involved in sulfur donor selectivity.
Mycobacterium tuberculosis UsfX (Rv3287c) exhibits novel nucleotide binding and hydrolysis properties.
Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase.
Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis.
Mycobacterium tuberculosis strains possess functional cellulases.
Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis.
Elongation of the Poly-gamma-glutamate Tail of F420 Requires Both Domains of the F420:gamma-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis.
Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations.
Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids.
The rpsL gene and streptomycin resistance in single and multiple drug-resistant strains of Mycobacterium tuberculosis.
Glutamine amidotransferase activity of NAD+ synthetase from Mycobacterium tuberculosis depends on an amino-terminal nitrilase domain.
Regulation of active site coupling in glutamine-dependent NAD(+) synthetase.
Regulation of the intersubunit ammonia tunnel in Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase.
The MTCY428.08 gene of Mycobacterium tuberculosis codes for NAD+ synthetase.
HemQ: An iron-coproporphyrin oxidative decarboxylase for protoheme synthesis in Firmicutes and Actinobacteria.
Prokaryotic heme biosynthesis: multiple pathways to a common essential product.
Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging.
Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin.
Mycothiol/mycoredoxin 1-dependent reduction of the peroxiredoxin AhpE from Mycobacterium tuberculosis.
Redox chemistry of Mycobacterium tuberculosis alkylhydroperoxide reductase E (AhpE): Structural and mechanistic insight into a mycoredoxin-1 independent reductive pathway of AhpE via mycothiol.
Revisiting sulfur H-bonds in proteins: The example of peroxiredoxin AhpE.
The active site architecture in peroxiredoxins: a case study on Mycobacterium tuberculosis AhpE.
Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics.
Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.
Structural and functional characterization of M. tuberculosis sedoheptulose-7-phosphate isomerase, a critical enzyme involved in lipopolysaccharide biosynthetic pathway.
Discovery and characterization of HemQ: an essential heme biosynthetic pathway component.
Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin.
In vivo inactivation of the mycobacterial integral membrane stearoyl coenzyme A desaturase DesA3 by a C-terminus-specific degradation process.
p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis.
MTC28, a novel 28-kilodalton proline-rich secreted antigen specific for the Mycobacterium tuberculosis complex.
Rv0901 from Mycobacterium tuberculosis, a possible novel virulent gene proved through the recombinant Mycobacterium smegmatis.
An unusual, His-dependent family I pyrophosphatase from Mycobacterium tuberculosis.
Analysis of stress- and host cell-induced expression of the Mycobacterium tuberculosis inorganic pyrophosphatase.
Mycobacterium tuberculosis Rv3628 drives Th1-type T cell immunity via TLR2-mediated activation of dendritic cells and displays vaccine potential against the hyper-virulent Beijing K strain.
Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis.
Structure of the Mycobacterium tuberculosis soluble inorganic pyrophosphatase Rv3628 at pH 7.0.
Identification of novel efflux proteins Rv0191, Rv3756c, Rv3008, and Rv1667c involved in pyrazinamide resistance in Mycobacterium tuberculosis.
Mycobacterium tuberculosis Rv0191 is an efflux pump of major facilitator superfamily transporter regulated by Rv1353c.
Biochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosis.
Functional reconstitution of the Mycobacterium tuberculosis long-chain acyl-CoA carboxylase from multiple acyl-CoA subunits.
Identification and characterization of Rv3281 as a novel subunit of a biotin-dependent acyl-CoA carboxylase in Mycobacterium tuberculosis H37Rv.
Rv2744c is a PspA ortholog that regulates lipid droplet homeostasis and nonreplicating persistence in Mycobacterium tuberculosis.
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.
Chemical shift assignments for Rv0577, a putative glyoxylase associated with virulence from Mycobacterium tuberculosis.
Mycobacterium tuberculosis Rv0577, a novel TLR2 agonist, induces maturation of dendritic cells and drives Th1 immune response.
The Mycobacterium tuberculosis complex-restricted gene cfp32 encodes an expressed protein that is detectable in tuberculosis patients and is positively correlated with pulmonary interleukin-10.
Disruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregation.
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.
Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs.
Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence.
Roles of the two type II NADH dehydrogenases in the survival of Mycobacterium tuberculosis in vitro.
The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis.
A cooperative oxygen binding hemoglobin from Mycobacterium tuberculosis. Stabilization of heme ligands by a distal tyrosine residue.
Cyanide binding to truncated hemoglobins: a crystallographic and kinetic study.
Heme-ligand tunneling in group I truncated hemoglobins.
Ligand interactions in the distal heme pocket of Mycobacterium tuberculosis truncated hemoglobin N: roles of TyrB10 and GlnE11 residues.
Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme.
Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates.
Aminoglycoside 2'-N-acetyltransferase genes are universally present in mycobacteria: characterization of the aac(2')-Ic gene from Mycobacterium tuberculosis and the aac(2')-Id gene from Mycobacterium smegmatis.
Distinct functional properties of secretory L-asparaginase Rv1538c involved in phagosomal survival of Mycobacterium tuberculosis.
Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis.
The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol.
A multicopper oxidase is required for copper resistance in Mycobacterium tuberculosis.
Mycobacterium tuberculosis Des protein: an immunodominant target for the humoral response of tuberculous patients.
Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD.
mmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis.
A nanocompartment system contributes to defense against oxidative stress in Mycobacterium tuberculosis.
Characterization of a Mycobacterium tuberculosis nanocompartment and its potential cargo proteins.
Identification and characterization of a 29-kilodalton protein from Mycobacterium tuberculosis culture filtrate recognized by mouse memory effector cells.
Large-scale computational discovery and analysis of virus-derived microbial nanocompartments.
Proteomic analysis identifies highly antigenic proteins in exosomes from M. tuberculosis-infected and culture filtrate protein-treated macrophages.
Mutations in Mycobacterium tuberculosis Rv0444c, the gene encoding anti-sigK, explain high level expression of MPB70 and MPB83 in Mycobacterium bovis.
Biochemical characterization of recombinant guaA-encoded guanosine monophosphate synthetase (EC 6.3.5.2) from Mycobacterium tuberculosis H37Rv strain.
Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats.
Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase.
Crystallographic observation of the movement of the membrane-distal domain of the T7SS core component EccB1 from Mycobacterium tuberculosis.
LppM impact on the colonization of macrophages by Mycobacterium tuberculosis.
Mycobacterium tuberculosis LppM displays an original structure and domain composition linked to a dual localization.
The urease locus of Mycobacterium tuberculosis and its utilization for the demonstration of allelic exchange in Mycobacterium bovis bacillus Calmette-Guerin.
Discovery of a siderophore export system essential for virulence of Mycobacterium tuberculosis.
Interdomain communication in the Mycobacterium tuberculosis environmental phosphatase Rv1364c.
Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c.
Role of a PAS sensor domain in the Mycobacterium tuberculosis transcription regulator Rv1364c.
Structural characterization of the multidomain regulatory protein Rv1364c from Mycobacterium tuberculosis.
Tuning the Mycobacterium tuberculosis alternative sigma factor SigF through the multidomain regulator Rv1364c and osmosensory kinase protein kinase D.
Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis.
NMR assignment and secondary structure of the STAS domain of Rv1739c, a putative sulfate transporter of Mycobacterium tuberculosis.
Mycobacterium tuberculosis CwsA interacts with CrgA and Wag31, and the CrgA-CwsA complex is involved in peptidoglycan synthesis and cell shape determination.
PPE26 induces TLR2-dependent activation of macrophages and drives Th1-type T-cell immunity by triggering the cross-talk of multiple pathways involved in the host response.
Mycobacterium tuberculosis Rv1474c is a TetR-like transcriptional repressor that regulates aconitase, an essential enzyme and RNA-binding protein, in an iron-responsive manner.
The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases.
Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant.
Structural, biochemical, and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis.
Molecular and immunological characterization of the highly conserved antigen 84 from Mycobacterium tuberculosis and Mycobacterium leprae.
The wag31 gene of Mycobacterium tuberculosis is positively regulated by the stringent response.
Wag31, a homologue of the cell division protein DivIVA, regulates growth, morphology and polar cell wall synthesis in mycobacteria.
Structural basis of DNA sequence recognition by the response regulator PhoP in Mycobacterium tuberculosis.
Structure of the response regulator PhoP from Mycobacterium tuberculosis reveals a dimer through the receiver domain.
Biochemical characterization of recombinant phosphoglucose isomerase of Mycobacterium tuberculosis.
Crystallization and preliminary X-ray characterization of phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv.
Functional phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv: rapid purification with high yield and purity.
Structural studies of phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv.
Characterization of a novel exported esterase Rv3036c from Mycobacterium tuberculosis.
CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence.
Mycobacterium tuberculosis PPE51 Inhibits Autophagy by Suppressing Toll-Like Receptor 2-Dependent Signaling.
PPE51 Is Involved in the Uptake of Disaccharides by Mycobacterium tuberculosis.
PPE51 mediates uptake of trehalose across the mycomembrane of Mycobacterium tuberculosis.
Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases.
Role of Mycobacterium tuberculosis Ser/Thr kinase PknF: implications in glucose transport and cell division.
Serine/threonine protein kinases PknF and PknG of Mycobacterium tuberculosis: characterization and localization.
The Mycobacterium tuberculosis GroEL1 chaperone is a substrate of Ser/Thr protein kinases.
Crystal structures of the Mycobacterium tuberculosis secretory antigen alanine dehydrogenase (Rv2780) in apo and ternary complex forms captures 'open' and 'closed' enzyme conformations.
Isolation of a 43 kDa protein from Mycobacterium tuberculosis H37Rv and its identification as a pyridine nucleotide transhydrogenase.
Properties of the 40 kDa antigen of Mycobacterium tuberculosis, a functional L-alanine dehydrogenase.
Structure and function of a 40,000-molecular-weight protein antigen of Mycobacterium tuberculosis.
Three-dimensional structures of apo- and holo-L-alanine dehydrogenase from Mycobacterium tuberculosis reveal conformational changes upon coenzyme binding.
Identification and functional characterization of thioredoxin of Mycobacterium tuberculosis.
Structure of Mycobacterium tuberculosis thioredoxin C.
Purification and characterization of mycobacterial phospholipase A: an activity associated with mycobacterial cutinase.
A Sir2-like protein participates in mycobacterial NHEJ.
Domain structure of a NHEJ DNA repair ligase from Mycobacterium tuberculosis.
Identification of a DNA nonhomologous end-joining complex in bacteria.
Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C.
Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine.
Interaction of Mycobacterium tuberculosis RshA and SigH is mediated by salt bridges.
Regulation of the SigH stress response regulon by an essential protein kinase in Mycobacterium tuberculosis.
RshA mimetic peptides inhibiting the transcription driven by a Mycobacterium tuberculosis sigma factor SigH.
RshA, an anti-sigma factor that regulates the activity of the mycobacterial stress response sigma factor SigH.
Cloning, expression, purification, crystallization and preliminary X-ray studies of epoxide hydrolases A and B from Mycobacterium tuberculosis.
Characterization of two genes encoding the Mycobacterium tuberculosis ribonucleotide reductase small subunit.
Ribonucleotide reduction in Mycobacterium tuberculosis: function and expression of genes encoding class Ib and class II ribonucleotide reductases.
Cloning of a gene from Mycobacterium tuberculosis coding for a hypothetical 27 kDa protein and its use for the specific PCR identification of these mycobacteria.
Expression, immunochemical characterization and localization of the Mycobacterium tuberculosis protein p27.
Flagellin as a good carrier and potent adjuvant for Th1 response: study of mice immune response to the p27 (Rv2108) Mycobacterium tuberculosis antigen.
RNase E and HupB dynamics foster mycobacterial cell homeostasis and fitness.
A PCR method for the sequence analysis of the gyrA, polA and rnhA gene segments from mycobacteria.
Crystal structure of the DNA gyrase GyrA N-terminal domain from Mycobacterium tuberculosis.
Functional analysis of DNA gyrase mutant enzymes carrying mutations at position 88 in the A subunit found in clinical strains of Mycobacterium tuberculosis resistant to fluoroquinolones.
Next-generation ion torrent sequencing of drug resistance mutations in Mycobacterium tuberculosis strains.
Selection of a gyrA mutant of Mycobacterium tuberculosis resistant to fluoroquinolones during treatment with ofloxacin.
Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-binding: requirement for establishing chronic persistent infection.
Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) are dominant positive repressors of IdeR-regulated genes in M. tuberculosis.
Propionate represses the dnaA gene via the methylcitrate pathway-regulating transcription factor, PrpR, in Mycobacterium tuberculosis.
Molecular characterization of Mycobacterium tuberculosis cystathionine gamma synthase--apo- and holoforms.
Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis.
Identification of a cadmium-induced gene in Mycobacterium bovis and Mycobacterium tuberculosis.
Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.
Indoleamides are active against drug-resistant Mycobacterium tuberculosis.
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane.
MmpL3 a potential new target for development of novel anti-tuberculosis drugs.
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212.
Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis.
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.
Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3.
Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies.
Use of a "silver bullet" to resolve crystal lattice dislocation disorder: a cobalamin complex of 1-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis.
Use of a "silver bullet" to resolve crystal lattice dislocation disorder: a cobalamin complex of Delta1-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis.
Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens.
Product chain-length determination mechanism of Z,E-farnesyl diphosphate synthase.
Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis.
An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses.
Bacterial protein reshapes host defense toward antiviral responses.
Structural and functional evidence that lipoprotein LpqN supports cell envelope biogenesis in Mycobacterium tuberculosis.
Characterization of Rv3868, an essential hypothetical protein of the ESX-1 secretion system in Mycobacterium tuberculosis.
Crystal structure of the N-terminal domain of EccA ATPase from the ESX-1 secretion system of Mycobacterium tuberculosis.
The AraC family transcriptional regulator Rv1931c plays a role in the virulence of Mycobacterium tuberculosis.
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.
A vitamin B12 transporter in Mycobacterium tuberculosis.
BacA, an ABC transporter involved in maintenance of chronic murine infections with Mycobacterium tuberculosis.
A bicarbonate cofactor modulates 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase in menaquinone biosynthesis of Escherichia coli.
Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis.
Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member.
Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms.
A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis in Mycobacterium.
An essential two-component signal transduction system in Mycobacterium tuberculosis.
Elements of signal transduction in Mycobacterium tuberculosis: in vitro phosphorylation and in vivo expression of the response regulator MtrA.
Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator.
Mycobacterium tuberculosis mtrA merodiploid strains with point mutations in the signal-receiving domain of MtrA exhibit growth defects in nutrient broth.
Septal localization of the Mycobacterium tuberculosis MtrB sensor kinase promotes MtrA regulon expression.
Association of strong immune responses to PPE protein Rv1168c with active tuberculosis.
Cloning, expression, and refolding of PPE17 protein of Mycobacterium tuberculosis as a promising vaccine candidate.
PPE17 (Rv1168c) protein of Mycobacterium tuberculosis detects individuals with latent TB infection.
Proline-proline-glutamic acid (PPE) protein Rv1168c of Mycobacterium tuberculosis augments transcription from HIV-1 long terminal repeat promoter.
The Mycobacterium tuberculosis PPE protein Rv1168c induces stronger B cell response than Rv0256c in active TB patients.
The N-terminal domain of Mycobacterium tuberculosis PPE17 (Rv1168c) protein plays a dominant role in inducing antibody responses in active TB patients.
Transduction of functionally contrasting signals by two Mycobacterial PPE proteins downstream of TLR2 receptors.
Deletion and overexpression studies on DacB2, a putative low molecular mass penicillin binding protein from Mycobacterium tuberculosis H(37)Rv.
Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis.
Phenotypic characterization of a novel double knockout PknI/DacB2 from Mycobacterium tuberculosis.
Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis.
A structural basis for the role of nucleotide specifying residues in regulating the oligomerization of the Rv1625c adenylyl cyclase from M. tuberculosis.
Adenylyl cyclase Rv1625c of Mycobacterium tuberculosis: a progenitor of mammalian adenylyl cyclases.
Eukaryotic-like adenylyl cyclases in Mycobacterium tuberculosis H37Rv: cloning and characterization.
New structural forms of a mycobacterial adenylyl cyclase Rv1625c.
PhoY2 but not PhoY1 is the PhoU homologue involved in persisters in Mycobacterium tuberculosis.
Lipoprotein LprI of Mycobacterium tuberculosis acts as a lysozyme inhibitor.
Structure of translation initiation factor 1 from Mycobacterium tuberculosis and inferred binding to the 30S ribosomal subunit.
Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by the antibiotic D-cycloserine.
Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine.
Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids.
Hemolytic phospholipase Rv0183 of Mycobacterium tuberculosis induces inflammatory response and apoptosis in alveolar macrophage RAW264.7 cells.
IL-6 release of Rv0183 antigen-stimulated whole blood is a potential biomarker for active tuberculosis patients.
Potential selective inhibitors against Rv0183 of Mycobacterium tuberculosis targeting host lipid metabolism.
The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition.
Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.
CYP51-like gene of Mycobacterium tuberculosis actually encodes a P450 similar to eukaryotic CYP51.
Characterization and catalytic properties of the sterol 14 alpha-demethylase from Mycobacterium tuberculosis.
Crystal structure of cytochrome P450 14 alpha-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors.
Estriol bound and ligand-free structures of sterol 14alpha-demethylase.
Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
Structural requirements for substrate recognition of Mycobacterium tuberculosis 14alpha-demethylase: implications for sterol biosynthesis.
Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.
X-ray structure of 4,4'-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14alpha-demethylase (CYP51).
M. tuberculosis sliding beta-clamp does not interact directly with the NAD+-dependent DNA ligase.
Redox homeostasis in Mycobacterium tuberculosis is modulated by a novel actinomycete-specific transcription factor.
Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2.
Crystal structure of the large subunit of cobaltochelatase from Mycobacterium tuberculosis.
Long-range replica exchange molecular dynamics guided drug repurposing against tyrosine kinase PtkA of Mycobacterium tuberculosis.
Mycobacterial protein tyrosine kinase, PtkA phosphorylates PtpA at tyrosine residues and the mechanism is stalled by the novel series of inhibitors.
Phosphorylation of Mycobacterium tuberculosis protein tyrosine kinase A PtkA by Ser/Thr protein kinases.
Protein tyrosine kinase, PtkA, is required for Mycobacterium tuberculosis growth in macrophages.
Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A.
The domain architecture of PtkA, the first tyrosine kinase from Mycobacterium tuberculosis, differs from the conventional kinase architecture.
Cyclodipeptide synthases arec a family of tRNA-dependent peptide bond-forming enzymes.
The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase.
Role of narK2X and narGHJI in hypoxic upregulation of nitrate reduction by Mycobacterium tuberculosis.
The structural basis of signal transduction for the response regulator PrrA from Mycobacterium tuberculosis.
An RNA-seq method for defining endoribonuclease cleavage specificity identifies dual rRNA substrates for toxin MazF-mt3.
Host-mediated ubiquitination of a mycobacterial protein suppresses immunity.
Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome.
Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c.
Mycobacterium tuberculosis releases an antacid that remodels phagosomes.
Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis.
Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis.
Expression, purification, crystallization and preliminary X-ray analysis of two arginine-biosynthetic enzymes from Mycobacterium tuberculosis.
The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism.
Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+.
Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis.
Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases.
Structural and biochemical characterization of the essential DsbA-like disulfide bond forming protein from Mycobacterium tuberculosis.
Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c.
Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.
Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids.
Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one.
Reverse type I inhibitor of Mycobacteriumtuberculosis CYP125A1.
The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis.
Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide.
Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis.
Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis.
A cadmium-lead-sensing ArsR-SmtB repressor with novel sensory sites. Complementary metal discrimination by NmtR and CmtR in a common cytosol.
NMR structural analysis of cadmium sensing by winged helix repressor CmtR.
Structural and functional characterization of Mycobacterium tuberculosis CmtR, a PbII/CdII-sensing SmtB/ArsR metalloregulatory repressor.
Characterization of Mycobacterium tuberculosis LexA: recognition of a Cheo (Bacillus-type SOS) box.
Isolation, purification and immunological characterization of novel low molecular weight protein antigen CFP 6 from culture filtrate of M. tuberculosis.
Bacterial proteasome activator Bpa (Rv3780) is a novel ring-shaped interactor of the mycobacterial proteasome.
Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome.
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice.
Inhibitors selective for mycobacterial versus human proteasomes.
Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity.
Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome.
Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate.
The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide.
Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Unusual structural, functional, and stability properties of serine hydroxymethyltransferase from Mycobacterium tuberculosis.
Intranasal delivery of DNA encoding antigens of Mycobacterium tuberculosis by non-pathogenic invasive Escherichia coli.
Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation.
Functional characterization of the precursor and spliced forms of RecA protein of Mycobacterium tuberculosis.
Novel structure of the recA locus of Mycobacterium tuberculosis implies processing of the gene product.
Protein splicing in the maturation of M. tuberculosis recA protein: a mechanism for tolerating a novel class of intervening sequence.
M. tuberculosis AlkX encoded by rv3249c regulates a conserved alkane hydroxylase system that is important for replication in macrophages and biofilm formation.
M.tb-Rv2462c of Mycobacterium tuberculosis Shows Chaperone-like Activity and Plays a Role in Stress Adaptation and Immunomodulation.
Crystal structures of manganese-dependent transcriptional repressor MntR (Rv2788) from Mycobacterium tuberculosis in apo and manganese bound forms.
Functional analysis of DNA replication fork reversal catalyzed by Mycobacterium tuberculosis RuvAB proteins.
Characterization of Guided Entry of Tail-Anchored Proteins 3 Homologues in Mycobacterium tuberculosis.
Substrate specificities and conformational flexibility of 3-ketosteroid 9alpha-hydroxylases.
Rv1075c of Mycobacterium tuberculosis is a GDSL-like esterase and is important for intracellular survival.
The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP.
Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis.
Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis.
Structure of the inactive variant C60S of Mycobacterium tuberculosis thiol peroxidase.
Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.
Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations.
Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics.
Directed evolution of Mycobacterium tuberculosis beta-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency.
Fluorogenic probes with substitutions at the 2 and 7 positions of cephalosporin are highly BlaC-specific for rapid Mycobacterium tuberculosis detection.
Genetic analysis of the beta-lactamases of Mycobacterium tuberculosis and Mycobacterium smegmatis and susceptibility to beta-lactam antibiotics.
Irreversible inhibition of the Mycobacterium tuberculosis beta-lactamase by clavulanate.
Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis.
NXL104 irreversibly inhibits the beta-lactamase from Mycobacterium tuberculosis.
Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe.
Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate.
Structures of the Michaelis complex (1.2 A) and the covalent acyl intermediate (2.0 A) of cefamandole bound in the active sites of the Mycobacterium tuberculosis beta-lactamase K73A and E166A mutants.
The twin-arginine translocation pathway of Mycobacterium smegmatis is functional and required for the export of mycobacterial beta-lactamases.
A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haem.
A distal tyrosine residue is required for ligand discrimination in DevS from Mycobacterium tuberculosis.
Activation of ATP binding for the autophosphorylation of DosS, a Mycobacterium tuberculosis histidine kinase lacking an ATP lid motif.
Blockage of the channel to heme by the E87 side chain in the GAF domain of Mycobacterium tuberculosis DosS confers the unique sensitivity of DosS to oxygen.
Crystal structures of the CO- and NO-bound DosS GAF-A domain and implications for DosS signaling in Mycobacterium tuberculosis.
DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy.
DevS, a heme-containing two-component oxygen sensor of Mycobacterium tuberculosis.
Distal hydrogen-bonding interactions in ligand sensing and signaling by Mycobacterium tuberculosis DosS.
DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis.
Structural insight into the heme-based redox sensing by DosS from Mycobacterium tuberculosis.
Structural and biochemical analyses of Mycobacterium tuberculosis N-acetylmuramyl-L-alanine amidase Rv3717 point to a role in peptidoglycan fragment recycling.
The structure of Rv3717 reveals a novel amidase from Mycobacterium tuberculosis.
Regions of high antigenicity within the hypothetical PPE major polymorphic tandem repeat open-reading frame, Rv2608, show a differential humoral response and a low T cell response in various categories of patients with tuberculosis.
Dissecting the role of critical residues and substrate preference of a fatty acyl-CoA synthetase (FadD13) of Mycobacterium tuberculosis.
Molecular modeling studies of Fatty acyl-CoA synthetase (FadD13) from Mycobacterium tuberculosis--a potential target for the development of antitubercular drugs.
The Mycobacterium tuberculosis very-long-chain fatty acyl-CoA synthetase: structural basis for housing lipid substrates longer than the enzyme.
Functional characterization delineates that a Mycobacterium tuberculosis specific protein kinase (Rv3080c) is responsible for the growth, phagocytosis and intracellular survival of avirulent mycobacteria.
Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation.
Mycobacterium tuberculosis protein kinase K enables growth adaptation through translation control.
The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS.
Peptides derived from Mycobacterium tuberculosis Rv2301 protein are involved in invasion to human epithelial cells and macrophages.
Crystal structure of the biologically active form of class Ib ribonucleotide reductase small subunit from Mycobacterium tuberculosis.
Molecular cloning and biochemical characterization of a serine threonine protein kinase, PknL, from Mycobacterium tuberculosis.
The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated by phosphorylation.
The Mycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c.
Functional characterization of a novel ArgA from Mycobacterium tuberculosis.
Mycobacterium tuberculosis H2S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility.
Three pathways for trehalose biosynthesis in mycobacteria.
Crystal structure of M tuberculosis ABC phosphate transport receptor: specificity and charge compensation dominated by ion-dipole interactions.
Mycobacterium tuberculosis 38-kDa antigen induces endoplasmic reticulum stress-mediated apoptosis via toll-like receptor 2/4.
Mycobacterium tuberculosis 38-kDa lipoprotein is apoptogenic for human monocyte-derived macrophages.
Mycobacterium tuberculosis PstS1 amplifies IFN-gamma and induces IL-17/IL-22 responses by unrelated memory CD4+ T cells via dendritic cell activation.
Phosphate starvation enhances expression of the immunodominant 38-kilodalton protein antigen of Mycobacterium tuberculosis: demonstration by immunogold electron microscopy.
Structure and mapping of antigenic domains of protein antigen b, a 38,000-molecular-weight protein of Mycobacterium tuberculosis.
TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
The immunodominant 38-kDa lipoprotein antigen of Mycobacterium tuberculosis is a phosphate-binding protein.
Cloning, overexpression, and characterization of a serine/threonine protein kinase pknI from Mycobacterium tuberculosis H37Rv.
Protein kinase I of Mycobacterium tuberculosis: cellular localization and expression during infection of macrophage-like cells.
Structural insight into the activation of PknI kinase from M.tuberculosis via dimerization of the extracellular sensor domain.
The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.
The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection.
Cascade of extracytoplasmic function sigma factors in Mycobacterium tuberculosis: identification of a sigmaJ-dependent promoter upstream of sigI.
A species-specific nucleotide sequence of Mycobacterium tuberculosis encodes a protein that exhibits hemolytic activity when expressed in Escherichia coli.
Analysis of genetic polymorphism in the phospholipase region of Mycobacterium tuberculosis.
Evidence for the expression of native Mycobacterium tuberculosis phospholipase C: recognition by immune sera and detection of promoter activity.
Isolation, characterization, and molecular cloning of a specific Mycobacterium tuberculosis antigen gene: identification of a species-specific sequence.
Tuberculosis: new strategies for the development of diagnostic tests and vaccines.
Substrate specificities and functional characterization of a thermo-tolerant uracil DNA glycosylase (UdgB) from Mycobacterium tuberculosis.
Mycobacterium tuberculosis protein MoxR1 enhances virulence by inhibiting host cell death pathways and disrupting cellular bioenergetics.
Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.
A systems approach to decipher a role of transcription factor RegX3 in the adaptation of Mycobacterium tuberculosis to hypoxic stress.
Control of CydB and GltA1 expression by the SenX3 RegX3 two component regulatory system of Mycobacterium tuberculosis.
Dual control of RegX3 transcriptional activity by SenX3 and PknB.
Identification of novel intergenic repetitive units in a mycobacterial two-component system operon.
Mycobacterium tuberculosis PhoY proteins promote persister formation by mediating Pst/SenX3-RegX3 phosphate sensing.
The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence.
The structure of a full-length response regulator from Mycobacterium tuberculosis in a stabilized three-dimensional domain-swapped, activated state.
Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells.
Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells.
The type I NADH dehydrogenase of Mycobacterium tuberculosis counters phagosomal NOX2 activity to inhibit TNF-alpha-mediated host cell apoptosis.
Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin-antitoxin assembly.
Identification of critical residues of the mycobacterial dephosphocoenzyme a kinase by site-directed mutagenesis.
Insights into the regulatory characteristics of the mycobacterial dephosphocoenzyme A kinase: implications for the universal CoA biosynthesis pathway.
The role of UPF0157 in the folding of M. tuberculosis dephosphocoenzyme A kinase and the regulation of the latter by CTP.
Identification of a novel mycobacterial 3-hydroxyacyl-thioester dehydratase, HtdZ (Rv0130), by functional complementation in yeast.
Structure and function of Rv0130, a conserved hypothetical protein from Mycobacterium tuberculosis.
AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strain.
Expression, purification and preliminary crystallographic analysis of Rv2247, the beta subunit of acyl-CoA carboxylase (ACCD6) from Mycobacterium tuberculosis.
Structure, activity, and inhibition of the carboxyltransferase beta-subunit of acetyl coenzyme A carboxylase (AccD6) from Mycobacterium tuberculosis.
Molecular features governing the stability and specificity of functional complex formation by Mycobacterium tuberculosis CFP-10/ESAT-6 family proteins.
Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking.
Solution structure of the Mycobacterium tuberculosis EsxG.EsxH complex: functional implications and comparisons with other M. tuberculosis Esx family complexes.
7,8-Diaminoperlargonic acid aminotransferase from Mycobacterium tuberculosis, a potential therapeutic target. Characterization and inhibition studies.
Mycobacterium tuberculosis PE25/PPE41 protein complex induces activation and maturation of dendritic cells and drives Th2-biased immune responses.
Mycobacterium tuberculosis PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation?
Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion.
Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer.
The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response.
Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis.
Binding pocket alterations in dihydrofolate synthase confer resistance to para-aminosalicylic acid in clinical isolates of Mycobacterium tuberculosis.
Purification, crystallization and preliminary X-ray analysis of Mycobacterium tuberculosis folylpolyglutamate synthase (MtbFPGS).
Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP.
Biochemical and genetic analysis of the four DNA ligases of mycobacteria.
Expression and purification of SenX3 from the Mycobacterium tuberculosis strain H37Rv in Escherichia coli.
Virulence factor SenX3 is the oxygen-controlled replication switch of Mycobacterium tuberculosis.
Backbone structure of a small helical integral membrane protein: A unique structural characterization.
Amplification and cloning of the Mycobacterium tuberculosis dnaA gene.
Attenuation of Mycobacterium tuberculosis by disruption of a mas-like gene or a chalcone synthase-like gene, which causes deficiency in dimycocerosyl phthiocerol synthesis.
Differential fadE28 expression associated with phenotypic virulence of Mycobacterium tuberculosis.
Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis.
Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.
Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes.
Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase.
1.9 A structure of the signal receiver domain of the putative response regulator NarL from Mycobacterium tuberculosis.
EspI regulates the ESX-1 secretion system in response to ATP levels in Mycobacterium tuberculosis.
Recombinant preparation and functional studies of EspI ATP binding domain from Mycobacterium tuberculosis.
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase.
Expression and characterization of the carboxyl esterase Rv3487c from Mycobacterium tuberculosis.
Functional characterization of the phospholipase C activity of Rv3487c and its localization on the cell wall of Mycobacterium tuberculosis.
Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis.
High throughput screen identifies small molecule inhibitors specific for Mycobacterium tuberculosis phosphoserine phosphatase.
Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.
Design, synthesis and biological evaluation of sugar-derived esters, alpha-ketoesters and alpha-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85C.
Genetic and immunological analysis of Mycobacterium tuberculosis fibronectin-binding proteins.
Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelope.
The genes coding for the antigen 85 complexes of Mycobacterium tuberculosis and Mycobacterium bovis BCG are members of a gene family: cloning, sequence determination, and genomic organization of the gene coding for antigen 85-C of M. tuberculosis.
Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis.
Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis.
Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function.
Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing.
Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.
Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae.
The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.
Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis.
Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence.
Insights into the substrate specificity of a thioesterase Rv0098 of Mycobacterium tuberculosis through X-ray crystallographic and molecular dynamics studies.
Trehalose-phosphate synthase of Mycobacterium tuberculosis. Cloning, expression and properties of the recombinant enzyme.
Cloning, expression, purification, crystallization and X-ray crystallographic analysis of Rv3168 from Mycobacterium tuberculosis H37Rv.
Crystal structure of Mycobacterium tuberculosis Rv3168: a putative aminoglycoside antibiotics resistance enzyme.
Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity.
An Aspartate-Specific Solute-Binding Protein Regulates Protein Kinase G Activity To Control Glutamate Metabolism in Mycobacteria.
Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway.
Trehalose synthase converts glycogen to trehalose.
The PGRS domain of Mycobacterium tuberculosis PE_PGRS protein Rv0297 is involved in endoplasmic reticulum stress-mediated apoptosis through Toll-like receptor 4.
Characterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis.
Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis.
GtrA protein Rv3789 is required for arabinosylation of arabinogalactan in Mycobacterium tuberculosis.
Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis.
Transfer of the first arabinofuranose residue to galactan is essential for Mycobacterium smegmatis viability.
Cloning, expression, and characterization of polyphosphate glucokinase from Mycobacterium tuberculosis.
A new family of phosphoinositide phosphatases in microorganisms: identification and biochemical analysis.
Deciphering the genes involved in pathogenesis of Mycobacterium tuberculosis.
Disruption of mptpB impairs the ability of Mycobacterium tuberculosis to survive in guinea pigs.
Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.
Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.
Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).
Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages.
MptpB promotes mycobacteria survival by inhibiting the expression of inflammatory mediators and cell apoptosis in macrophages.
MptpB, a virulence factor from Mycobacterium tuberculosis, exhibits triple-specificity phosphatase activity.
Mycobacterium tuberculosis protein tyrosine phosphatase PtpB structure reveals a diverged fold and a buried active site.
Structural basis for selective inhibition of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB.
Structural insights into mode of actions of novel natural Mycobacterium protein tyrosine phosphatase B inhibitors.
Structure-based design of MptpB inhibitors that reduce multidrug-resistant Mycobacterium tuberculosis survival and infection burden in vivo.
Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents.
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy.
The crystal structure of Mycobacterium tuberculosis high-temperature requirement A protein reveals an autoregulatory mechanism.
The crystal structure of an essential high-temperature requirement protein HtrA1 (Rv1223) from Mycobacterium tuberculosis reveals its unique features.
Attenuation of virulence by disruption of the Mycobacterium tuberculosis erp gene.
Characterization of the Mycobacterium tuberculosis erp gene encoding a potential cell surface protein with repetitive structures.
Identification of Mycobacterium tuberculosis DNA sequences encoding exported proteins by using phoA gene fusions.
Expression and characterization of Rv0447c product, potentially the methyltransferase involved in tuberculostearic acid biosynthesis in Mycobacterium tuberculosis.
Characterization of lipoyl synthase from Mycobacterium tuberculosis.
Crystallographic snapshots of sulfur insertion by lipoyl synthase.
Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway.
Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery.
The Mycobacterium tuberculosis ORF Rv0654 encodes a carotenoid oxygenase mediating central and excentric cleavage of conventional and aromatic carotenoids.
PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis.
Characterization of novel acyl coenzyme A dehydrogenases involved in bacterial steroid degradation.
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase.
The prodrug activator EtaA from Mycobacterium tuberculosis is a Baeyer-Villiger monooxygenase.
5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins.
Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain.
Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis.
Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of Mycobacterium tuberculosis.
A phagosomally expressed gene, rv0428c, of Mycobacterium tuberculosis demonstrates acetyl transferase activity and plays a protective role under stress conditions.
Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin.
The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination.
Dormancy associated translation inhibitor (DATIN/Rv0079) of Mycobacterium tuberculosis interacts with TLR2 and induces proinflammatory cytokine expression.
Function prediction of Rv0079, a hypothetical Mycobacterium tuberculosis DosR regulon protein.
Mycobacterium tuberculosis DosR regulon gene Rv0079 encodes a putative, 'dormancy associated translation inhibitor (DATIN)'.
Targeting DnaN for tuberculosis therapy using novel griselimycins.
A major antigen from Mycobacterium tuberculosis which is homologous to the heat shock proteins groES from E. coli and the htpA gene product of Coxiella burneti.
Cloning and sequence analysis of the 10 kDa antigen gene of Mycobacterium tuberculosis.
Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis.
Mycobacterium tuberculosis chaperonin 10 heptamers self-associate through their biologically active loops.
Mycobacterium tuberculosis expresses two chaperonin-60 homologs.
The Mycobacterium tuberculosis BCG-a protein has homology with the Escherichia coli GroES protein.
Detection of embB codon 306 mutations in ethambutol resistant Mycobacterium tuberculosis directly from sputum samples: a low-cost, rapid approach.
Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations.
2.3 A X-ray structure of the heme-bound GAF domain of sensory histidine kinase DosT of Mycobacterium tuberculosis.
Cross talk between DevS sensor kinase homologue, Rv2027c, and DevR response regulator of Mycobacterium tuberculosis.
A novel function of Mycobacterium tuberculosis chaperonin paralog GroEL1 in copper homeostasis.
Facilitated oligomerization of mycobacterial GroEL: evidence for phosphorylation-mediated oligomerization.
Interplays between copper and Mycobacterium tuberculosis GroEL1.
Structural and functional conservation of Mycobacterium tuberculosis GroEL paralogs suggests that GroEL1 is a chaperonin.
Towards understanding the biological function of the unusual chaperonin Cpn60.1 (GroEL1) of Mycobacterium tuberculosis.
Structural characterization of glycinamide-RNase-transformylase T from Mycobacterium tuberculosis.
Atypical DNA recognition mechanism used by the EspR virulence regulator of Mycobacterium tuberculosis.
Cloning, purification, crystallization and preliminary X-ray analysis of ESX-1-secreted protein regulator (EspR) from Mycobacterium tuberculosis.
Comparison of four different crystal forms of the Mycobacterium tuberculosis ESX-1 secreted protein regulator EspR.
EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins.
Functional analysis of the EspR binding sites upstream of espR in Mycobacterium tuberculosis.
Functional dissection of intersubunit interactions in the EspR virulence regulator of Mycobacterium tuberculosis.
Virulence regulator EspR of Mycobacterium tuberculosis is a nucleoid-associated protein.
HemZ is essential for heme biosynthesis in Mycobacterium tuberculosis.
Identification of [2Fe-2S] clusters in microbial ferrochelatases.
MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence.
The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis.
Rv3272 encodes a novel family III CoA transferase that alters the cell wall lipid profile and protects mycobacteria from acidic and oxidative stress.
Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis.
Mycobacterium tuberculosis Rv3586 (DacA) is a diadenylate cyclase that converts ATP or ADP into c-di-AMP.
Radiation-sensitive gene A (RadA) targets DisA, DNA integrity scanning protein A, to negatively affect cyclic di-AMP synthesis activity in Mycobacterium smegmatis.
Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.
ChiZ levels modulate cell division process in mycobacteria.
Interference of Mycobacterium tuberculosis cell division by Rv2719c, a cell wall hydrolase.
The mycobacterium-specific gene Rv2719c is DNA damage inducible independently of RecA.
A specific secretion system mediates PPE41 transport in pathogenic mycobacteria.
Mycobacterium tuberculosis PE9 protein has high activity binding peptides which inhibit target cell invasion.
The Mycobacterium tuberculosis protein pair PE9 (Rv1088)-PE10 (Rv1089) forms heterodimers and induces macrophage apoptosis through Toll-like receptor 4.
Insights into the function of the WhiB-like protein of mycobacteriophage TM4--a transcriptional inhibitor of WhiB2.
WhiB2/Rv3260c, a cell division-associated protein of Mycobacterium tuberculosis H37Rv, has properties of a chaperone.
Intermolecular interactions in the AhpC/AhpD antioxidant defense system of Mycobacterium tuberculosis.
The AhpC and AhpD antioxidant defense system of Mycobacterium tuberculosis.
The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design.
The mechanism of Mycobacterium tuberculosis alkylhydroperoxidase AhpD as defined by mutagenesis, crystallography, and kinetics.
CtpA, a putative Mycobacterium tuberculosis P-type ATPase, is stimulated by copper (I) in the mycobacterial plasma membrane.
Identification of Mycobacterium tuberculosis genes preferentially expressed during human infection.
Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis.
Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302.
The crystal structure of AcrR from Mycobacterium tuberculosis reveals a one-component transcriptional regulation mechanism.
The crystal structure of AcrR from Mycobacteriumtuberculosis reveals a one-component transcriptional regulation mechanism.
Characterization of a chromosomal toxin-antitoxin, Rv1102c-Rv1103c system in Mycobacterium tuberculosis.
Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site.
Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.
Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13.
Crystallization and structure analysis of the core motif of the Pks13 acyltransferase domain from Mycobacterium tuberculosis.
Development of a novel lead that targets M.tuberculosis polyketide synthase 13.
Identification of novel coumestan derivatives as polyketide synthase 13 inhibitors against Mycobacterium tuberculosis.
Identification of novel coumestan derivatives as polyketide synthase 13 inhibitors against Mycobacterium tuberculosis. Part II.
The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis.
The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis.
The polyketide synthase Pks13 catalyzes a novel mechanism of lipid transfer in mycobacteria.
Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species.
The phosphatidyl-myo-inositol dimannoside acyltransferase PatA is essential for Mycobacterium tuberculosis growth in vitro and in vivo.
Thiophenecarboxamide derivatives activated by EthA kill Mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG.
Rv1027c-Rv1028c encode functional KdpDE two--component system in Mycobacterium tuberculosis.
Functional genomics reveals the sole sulphate transporter of the Mycobacterium tuberculosis complex and its relevance to the acquisition of sulphur in vivo.
A Mycobacterium tuberculosis ligand-binding Mn/Fe protein reveals a new cofactor in a remodeled R2-protein scaffold.
A dynamic C-terminal segment in the Mycobacterium tuberculosis Mn/Fe R2lox protein can adopt a helical structure with possible functional consequences.
Rv0233 is not essential for the survival of Mycobacterium tuberculosis in stress conditions.
Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions.
Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria.
Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis.