Genome sequence of the human malaria parasite Plasmodium falciparum.
Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development.
Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.
Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif.
Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.
A Plasmodium falciparum dipeptidyl aminopeptidase I participates in vacuolar hemoglobin degradation.
Biochemical characterization of Plasmodium falciparum dipeptidyl aminopeptidase 1.
O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes.
The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Dynamical features of the Plasmodium falciparum ribosome during translation.
Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum.
Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum.
Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum.
A Hetero-Multimeric Chitinase-Containing Plasmodium falciparum and Plasmodium gallinaceum Ookinete-Secreted Protein Complex Involved in Mosquito Midgut Invasion.
An anti-Chitinase malaria transmission-blocking single-chain antibody as an effector molecule for creating a Plasmodium falciparum-refractory mosquito.
Disruption of Plasmodium falciparum chitinase markedly impairs parasite invasion of mosquito midgut.
Micronemal transport of Plasmodium ookinete chitinases to the electron-dense area of the apical complex for extracellular secretion.
Structure-function analysis of cysteine residues in the plasmodium falciparum chitinase, PfCHT1.
The chitinase PfCHT1 from the human malaria parasite Plasmodium falciparum lacks proenzyme and chitin-binding domains and displays unique substrate preferences.
The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum.
Evidence for catalytic roles for Plasmodium falciparum aminopeptidase P in the food vacuole and cytosol.
Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum.
Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.
Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum.
Nedd8 hydrolysis by UCH proteases in Plasmodium parasites.
Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes.
Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design.
Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers.
Characterisation of the Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop).
Plasmodium falciparum Hop (PfHop) Interacts with the Hsp70 Chaperone in a Nucleotide-Dependent Fashion and Exhibits Ligand Selectivity.
Structural studies of the Hsp70/Hsp90 organizing protein of Plasmodium falciparum and its modulation of Hsp70 and Hsp90 ATPase activities.
Atomic resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other glutaredoxins.
The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei.
Male-specific expression of the paralog of malaria transmission-blocking target antigen Pfs230, PfB0400w.
The Plasmodium falciparum male gametocyte protein P230p, a paralog of P230, is vital for ookinete formation and mosquito transmission.
Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum.
P113 is a merozoite surface protein that binds the N terminus of Plasmodium falciparum RH5.
Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
New insights of falcipain 2 structure from Plasmodium falciparum 3D7 strain.
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Structure- and function-based design of Plasmodium-selective proteasome inhibitors.
The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.
An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum.
Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes.
Identification of Plasmodium falciparum reticulocyte binding protein homologue 5-interacting protein, PfRipr, as a highly conserved blood-stage malaria vaccine candidate.
Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial for Plasmodium falciparum erythrocyte invasion.
Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.
Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum.
Nuclease activity of Plasmodium falciparum Alba family protein PfAlba3.
PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malaria parasites.
A putative Sec23 homologue of Plasmodium falciparum is located in Maurer's clefts.
Crystal structure of S-adenosyl-L-homocysteine hydrolase from the human malaria parasite Plasmodium falciparum.
Plasmodium falciparum S-adenosylhomocysteine hydrolase. cDNA identification, predicted protein sequence, and expression in Escherichia coli.
Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral membrane protein.
PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum.
Structural characterization and inhibition of the Plasmodium Atg8-Atg3 interaction.
Cloning and characterization of ferredoxin and ferredoxin-NADP+ reductase from human malaria parasite.
Ferredoxin-NADP+ reductase from Plasmodium falciparum undergoes NADP+-dependent dimerization and inactivation: functional and crystallographic analysis.
Plasmodium falciparum ferredoxin-NADP+ reductase His286 plays a dual role in NADP(H) binding and catalysis.
Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum.
The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.
X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP.
Compartmentation of redox metabolism in malaria parasites.
Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development.
Adenylate kinase and GTP:AMP phosphotransferase of the malarial parasite Plasmodium falciparum. Central players in cellular energy metabolism.
Subcellular localization of adenylate kinases in Plasmodium falciparum.
Structure of a putative ClpS N-end rule adaptor protein from the malaria pathogen Plasmodium falciparum.
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Histone lysine methyltransferases and demethylases in Plasmodium falciparum.
Targeting malaria virulence and remodeling proteins to the host erythrocyte.
Characterization of the ornithine aminotransferase from Plasmodium falciparum.
Redox regulation of Plasmodium falciparum ornithine delta-aminotransferase.
Tic22 is an essential chaperone required for protein import into the apicoplast.
PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum.
Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum.
A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites.
Cap-domain closure enables diverse substrate recognition by the C2-type haloacid dehalogenase-like sugar phosphatase Plasmodium falciparum HAD1.
Direct tests of cytochrome c and c1 functions in the electron transport chain of malaria parasites.
A fourth family of the Plasmodium falciparum S-antigen.
Malaria parasite translocon structure and mechanism of effector export.
Structural determinants of DNA binding by a P. falciparum ApiAP2 transcriptional regulator.
Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats.
Structural and functional insights into the malaria parasite moving junction complex.
Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction.
Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity.
Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism.
Plasmodium pseudo-Tyrosine Kinase-like binds PP1 and SERA5 and is exported to host erythrocytes.
Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis.
The crystal structure of superoxide dismutase from Plasmodium falciparum.
Features of apoptosis in Plasmodium falciparum erythrocytic stage through a putative role of PfMCA1 metacaspase-like protein.
Plasmodium falciparum metacaspase PfMCA-1 triggers a z-VAD-fmk inhibitable protease to promote cell death.
Inhibiting the Plasmodium eIF2alpha Kinase PK4 Prevents Artemisinin-Induced Latency.
PK4, a eukaryotic initiation factor 2alpha(eIF2alpha) kinase, is essential for the development of the erythrocytic cycle of Plasmodium.
Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum.
The human malaria parasite Plasmodium falciparum has distinct organelle-specific lipoylation pathways.
Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte.
Plasmodium falciparum signal peptidase is regulated by phosphorylation and required for intra-erythrocytic growth.
Acta Crystallogr Sect F Struct Biol Cryst Commun
Acta Crystallogr. F Struct. Biol. Commun.
Structure of the catalytic domain of Plasmodium falciparum ARF GTPase-activating protein (ARFGAP).
PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum.
Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein.
Structure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum.
Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design.
PfeIK1, a eukaryotic initiation factor 2alpha kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation.
UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages.
Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen.
Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA.
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody.
A central role for P48/45 in malaria parasite male gamete fertility.
Pfs47, paralog of the male fertility factor Pfs48/45, is a female specific surface protein in Plasmodium falciparum.
The human malaria parasite Pfs47 gene mediates evasion of the mosquito immune system.
Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum.
Plasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes.
Dual acylation of the 45 kDa gliding-associated protein (GAP45) in Plasmodium falciparum merozoites.
Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion.
Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.
A nonpeptidyl molecule modulates apoptosis-like cell death by inhibiting P. falciparum metacaspase-2.
Biochemical characterization of unusual cysteine protease of P. falciparum, metacaspase-2 (MCA-2).
A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites.
Binding of aldolase and glyceraldehyde-3-phosphate dehydrogenase to the cytoplasmic tails of Plasmodium falciparum merozoite duffy binding-like and reticulocyte homology ligands.
Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.
Plasmodium falciparum aldolase and the C-terminal cytoplasmic domain of certain apical organellar proteins promote actin polymerization.
The Binding of Plasmodium falciparum Adhesins and Erythrocyte Invasion Proteins to Aldolase Is Enhanced by Phosphorylation.
A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites.
PfCERLI1 is a conserved rhoptry associated protein essential for Plasmodium falciparum merozoite invasion of erythrocytes.
Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer's clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1.
Structural basis for RIFIN-mediated activation of LILRB1 in malaria.
Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum.
Effects of calcium signaling on Plasmodium falciparum erythrocyte invasion and post-translational modification of gliding-associated protein 45 (PfGAP45).
Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut.
Plasmodium falciparum erythrocyte invasion: a conserved myosin associated complex.
Secretion of an acid phosphatase provides a possible mechanism to acquire host nutrients by Plasmodium falciparum.
Tracking Glideosome-associated protein 50 reveals the development and organization of the inner membrane complex of Plasmodium falciparum.
Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen 5 triggers merozoite egress.
Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5.
Molecular Camouflage of Plasmodium falciparum Merozoites by Binding of Host Vitronectin to P47 Fragment of SERA5.
Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.
Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine.
Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes.
Synthetic peptides derived from the C-terminal 6kDa region of Plasmodium falciparum SERA5 inhibit the enzyme activity and malaria parasite development.
The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes.
Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.
A newly discovered protein export machine in malaria parasites.
Crystal structure and solution characterization of the thioredoxin-2 from Plasmodium falciparum, a constituent of an essential parasitic protein export complex.
Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery.
Thioredoxin networks in the malarial parasite Plasmodium falciparum.
Biochemical and functional analysis of two Plasmodium falciparum blood-stage 6-cys proteins: P12 and P41.
Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum.
Predicted disulfide-bonded structures for three uniquely related proteins of Plasmodium falciparum, Pfs230, Pfs48/45 and Pf12.
Structural and biochemical characterization of Plasmodium falciparum 12 (Pf12) reveals a unique interdomain organization and the potential for an antiparallel arrangement with Pf41.
Plasmodium falciparum SSB tetramer wraps single-stranded DNA with similar topology but opposite polarity to E. coli SSB.
GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli.
Structure of the (E)-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase from Plasmodium falciparum.
A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase.
Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases.
Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (PfM1AAP) and M17 leucyl aminopeptidase (PfM17LAP).
Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development.
Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.
Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases.
Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.
Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from Plasmodium falciparum.
The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors.
Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.
X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17.
Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum.
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase.
Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis.
A secretory multifunctional serine protease, DegP of Plasmodium falciparum, plays an important role in thermo-oxidative stress, parasite growth and development.
Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection.
An essential pentatricopeptide repeat protein in the apicomplexan remnant chloroplast.
Crystal structure of malaria parasite nucleosome assembly protein: distinct modes of protein localization and histone recognition.
Iodide-SAD, SIR and SIRAS phasing for structure solution of a nucleosome assembly protein.
A Plasmodium falciparum aminopeptidase gene belonging to the M1 family of zinc-metallopeptidases is expressed in erythrocytic stages.
A naturally variable residue in the S1 subsite of M1 family aminopeptidases modulates catalytic properties and promotes functional specialization.
Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation.
Distribution and biochemical properties of an M1-family aminopeptidase in Plasmodium falciparum indicate a role in vacuolar hemoglobin catabolism.
Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.
Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.
Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole.
Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.
Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase.
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.
Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the s1 pocket of the essential malaria m1 metalloaminopeptidase.
Activation of a Plasmodium falciparum cdc2-related kinase by heterologous p25 and cyclin H. Functional characterization of a P. falciparum cyclin homologue.
Identification and initial characterization of three novel cyclin-related proteins of the human malaria parasite Plasmodium falciparum.
Regulation of Plasmodium falciparum Origin Recognition Complex subunit 1 (PfORC1) function through phosphorylation mediated by CDK-like kinase PK5.
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum.
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum.
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum.
Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes.
Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.
One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen.
P. falciparum RH5-Basigin interaction induces changes in the cytoskeleton of the host RBC.
PfRH5: a novel reticulocyte-binding family homolog of plasmodium falciparum that binds to the erythrocyte, and an investigation of its receptor.
RH5-Basigin interaction plays a major role in the host tropism of Plasmodium falciparum.
Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum.
Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and fragmentation.
Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development.
Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability.
Rapid cadmium SAD phasing at the standard wavelength (1 A).
Structural differences explain diverse functions of Plasmodium actins.
The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity.
Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamer.
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes.
Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum.
Influence of Plasmodium falciparum Calcium-Dependent Protein Kinase 5 (PfCDPK5) on the Late Schizont Stage Phosphoproteome.
Crystal structure of Plasmodium falciparum adenosine deaminase reveals a novel binding pocket for inosine.
Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases.
Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights.
Plasmodium food vacuole plasmepsins are activated by falcipains.
Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum.
The role of Plasmodium falciparum food vacuole plasmepsins.
Trafficking of plasmepsin II to the food vacuole of the malaria parasite Plasmodium falciparum.
Binding of alpha,alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design.
Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection.
Structural metal dependency of the arginase from the human malaria parasite Plasmodium falciparum.
The activity of Plasmodium falciparum arginase is mediated by a novel inter-monomer salt-bridge between Glu295-Arg404.