Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.
Fungal isocyanide synthases and xanthocillin biosynthesis in Aspergillus fumigatus.
A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.
A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus.
An improved model of the Aspergillus fumigatus CYP51A protein.
Detection of Aspergillus fumigatus and a mutation that confers reduced susceptibility to itraconazole and posaconazole by real-time PCR and pyrosequencing.
Differences in interactions between azole drugs related to modifications in the 14-alpha sterol demethylase gene (cyp51A) of Aspergillus fumigatus.
Ergosterol biosynthesis pathway in Aspergillus fumigatus.
Identification of two different 14-alpha sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species.
In Vitro biochemical study of CYP51-mediated azole resistance in Aspergillus fumigatus.
In vitro and in vivo efficacy of a novel and long-acting fungicidal azole, PC1244, on Aspergillus fumigatus infection.
Modeling and interactions of Aspergillus fumigatus lanosterol 14-alpha demethylase 'A' with azole antifungals.
Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.
Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase.
Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma.
Rapid, high-throughput, multiplex, real-time PCR for identification of mutations in the cyp51A gene of Aspergillus fumigatus that confer resistance to itraconazole.
SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus.
SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).
SreA-mediated iron regulation in Aspergillus fumigatus.
Stereoselective interaction of SCH 39304, a triazole, with sterol 14alpha-demethylase of Aspergillus fumigatus.
Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs.
Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility.
The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus.
The structure-function relationship of the Aspergillus fumigatus cyp51A L98H conversion by site-directed mutagenesis: the mechanism of L98H azole resistance.
Three-dimensional models of 14alpha-sterol demethylase (Cyp51A) from Aspergillus lentulus and Aspergillus fumigatus: an insight into differences in voriconazole interaction.
Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole.
Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus.
Aflavinines and other antiinsectan metabolites from the ascostromata of Eupenicillium crustaceum and related species.
Characterization of two acetyltransferase genes in the pyripyropene biosynthetic gene cluster from Penicillium coprobium.
Characterization of two cytochrome P450 monooxygenase genes of the pyripyropene biosynthetic gene cluster from Penicillium coprobium.
Pyripyropenes, fungal sesquiterpenes conjugated with alpha-pyrone and pyridine moieties, exhibits anti-angiogenic activity against human umbilical vein endothelial cells.
Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases.
Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:cholesterol acyltransferase 2 isozyme.
Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection.
Fungal siderophore biosynthesis is partially localized in peroxisomes.
SidL, an Aspergillus fumigatus transacetylase involved in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin.
Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence.
The Aspergillus fumigatus siderophore biosynthetic gene sidA, encoding L-ornithine N(5)-oxygenase, is required for virulence.
Aspergillus fumigatus Hsp90 interacts with the main components of the cell wall integrity pathway and cooperates in heat shock and cell wall stress adaptation.
The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus.
The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus.
The cell wall integrity pathway contributes to the early stages of Aspergillus fumigatus asexual development.
Cloning and characterization of a sialidase from the filamentous fungus, Aspergillus fumigatus.
The Aspergillus fumigatus sialidase is a 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase (KDNase): structural and mechanistic insights.
The Aspergillus fumigatus sitA phosphatase homologue is important for adhesion, cell wall integrity, biofilm formation, and virulence.
Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family.
Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus.
Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus.
Functional coupling between the unfolded protein response and endoplasmic reticulum/Golgi Ca2+-ATPases promotes stress tolerance, cell wall biosynthesis, and virulence of Aspergillus fumigatus.
The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis.
Transcription factor somA is required for adhesion, development and virulence of the human pathogen Aspergillus fumigatus.
Role of trehalose biosynthesis in Aspergillus fumigatus development, stress response, and virulence.
Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
Erg4A and Erg4B are required for conidiation and azole resistance via regulation of ergosterol biosynthesis in Aspergillus fumigatus.
Identification of Aspergillus fumigatus multidrug transporter genes and their potential involvement in antifungal resistance.
Characterization of the efflux capability and substrate specificity of Aspergillus fumigatus PDR5-like ABC transporters expressed in Saccharomyces cerevisiae.
Contributions of Aspergillus fumigatus ATP-binding cassette transporter proteins to drug resistance and virulence.
Functional analysis of an ATP-binding cassette transporter protein from Aspergillus fumigatus by heterologous expression in Saccharomyces cerevisiae.
Cloning and expression of GH11 xylanase gene from Aspergillus fumigatus MKU1 in Pichia pastoris.
Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-alpha-1,4-galactosaminidase that disrupts microbial biofilms.
Ega3 from the fungal pathogen pii>Aspergillus fumigatuspi/i> is an endo-alpha-1,4-galactosaminidase that disrupts microbial biofilms.
Characterization of recombinant Aspergillus fumigatus mannitol-1-phosphate 5-dehydrogenase and its application for the stereoselective synthesis of protio and deuterio forms of D-mannitol 1-phosphate.
Polyol-specific long-chain dehydrogenases/reductases of mannitol metabolism in Aspergillus fumigatus: biochemical characterization and pH studies of mannitol 2-dehydrogenase and mannitol-1-phosphate 5-dehydrogenase.
Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatus.
Pyomelanin formation in Aspergillus fumigatus requires HmgX and the transcriptional activator HmgR but is dispensable for virulence.
Insight into the genome of Aspergillus fumigatus: analysis of a 922 kb region encompassing the nitrate assimilation gene cluster.
The role of the sakA (Hog1) and tcsB (sln1) genes in the oxidant adaptation of Aspergillus fumigatus.
Characterization of a cell-wall acid phosphatase (PhoAp) in Aspergillus fumigatus.
Proteome analysis of Aspergillus fumigatus identifies glycosylphosphatidylinositol-anchored proteins associated to the cell wall biosynthesis.
Structures of the glycosylphosphatidylinositol membrane anchors from Aspergillus fumigatus membrane proteins.
A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis.
Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus.
Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges.
Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway.
GliP, a multimodular nonribosomal peptide synthetase in Aspergillus fumigatus, makes the diketopiperazine scaffold of gliotoxin.
Gliotoxin is a virulence factor of Aspergillus fumigatus: gliP deletion attenuates virulence in mice immunosuppressed with hydrocortisone.
Gliotoxin production in Aspergillus fumigatus contributes to host-specific differences in virulence.
Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.
Interplay between gliotoxin resistance, secretion, and the methyl/methionine cycle in Aspergillus fumigatus.
Opposed effects of enzymatic gliotoxin N- and S-methylations.
Reconstitution of the early steps of gliotoxin biosynthesis in Aspergillus nidulans reveals the role of the monooxygenase GliC.
RsmA regulates Aspergillus fumigatus gliotoxin cluster metabolites including cyclo(L-Phe-L-Ser), a potential new diagnostic marker for invasive aspergillosis.
Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin.
The Aspergillus fumigatus protein GliK protects against oxidative stress and is essential for gliotoxin biosynthesis.
The role of glutathione S-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus.
An ergot alkaloid biosynthesis gene and clustered hypothetical genes from Aspergillus fumigatus.
Chemotypic and genotypic diversity in the ergot alkaloid pathway of Aspergillus fumigatus.
Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3.
Ergot alkaloid biosynthesis in Aspergillus fumigatus: FgaAT catalyses the acetylation of fumigaclavine B.
Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH.
Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus.
Ergot: from witchcraft to biotechnology.
Functional analysis of the gene controlling hydroxylation of festuclavine in the ergot alkaloid pathway of Neosartorya fumigata.
Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus.
Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus.
Crystallographic snapshots of Aspergillus fumigatus phytase, revealing its enzymatic dynamics.
Gene cloning, purification, and characterization of a heat-stable phytase from the fungus Aspergillus fumigatus.
Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatus.
The three Aspergillus fumigatus CFEM-domain GPI-anchored proteins (CfmA-C) affect cell-wall stability but do not play a role in fungal virulence.
Partial reconstruction of the ergot alkaloid pathway by heterologous gene expression in Aspergillus nidulans.
Aspergillus fumigatus MADS-Box transcription factor rlmA is required for regulation of the cell wall integrity and virulence.
The Aspergillus fumigatus pkcA G579R mutant is Defective in the activation of the cell wall integrity pathway but is dispensable for virulence in a neutropenic mouse infection model.
Transcriptional control of the production of Aspergillus fumigatus conidia-borne secondary metabolite fumiquinazoline C important for phagocytosis protection.
NosA, a transcription factor important in Aspergillus fumigatus stress and developmental response, rescues the germination defect of a laeA deletion.
Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA.
Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans.
Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi.
The structural basis of the low catalytic activities of the two minor beta-carbonic anhydrases of the filamentous fungus Aspergillus fumigatus.
An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis.
Fumagillin treatment of intestinal microsporidiosis.
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
Prototype of an intertwined secondary-metabolite supercluster.
The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2.
The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of beta-trans-bergamotene.
The fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatus.
The treatment of amebiasis with fumagillin.
Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus.
Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters in Aspergillus fumigatus.
Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cells.
Anti-inflammatory, cyclooxygenase (COX)-2, COX-1 inhibitory, and free radical scavenging effects of Rumex nepalensis.
Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus.
Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites.
Nonribosomal peptide synthesis in Aspergillus fumigatus and other fungi.
Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus.
Crystallographic characterization of the (R)-selective amine transaminase from Aspergillus fumigatus.
Structural and biochemical characterization of the dual substrate recognition of the (R)-selective amine transaminase from Aspergillus fumigatus.
Evolution of cross-resistance to medical triazoles in Aspergillus fumigatus through selection pressure of environmental fungicides.
Mutations in hmg1, challenging the paradigm of clinical triazole resistance in Aspergillus fumigatus.
A human IRE1 inhibitor blocks the unfolded protein response in the pathogenic fungus Aspergillus fumigatus and suggests noncanonical functions within the pathway.
HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus.
Identification of high-affinity copper transporters in Aspergillus fumigatus.
Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin.
Regulation of nonribosomal peptide synthesis: bis-thiomethylation attenuates gliotoxin biosynthesis in Aspergillus fumigatus.
Sequential inactivation of gliotoxin by the S-methyltransferase TmtA.
Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus.
A structural model of the Sgt2 protein and its interactions with chaperones and the Get4/Get5 complex.
The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro.
The Aspergillus fumigatus cellobiohydrolase B (cbhB) promoter is tightly regulated and can be exploited for controlled protein expression and RNAi.
Genes differentially expressed in conidia and hyphae of Aspergillus fumigatus upon exposure to human neutrophils.
A developmentally regulated gene cluster involved in conidial pigment biosynthesis in Aspergillus fumigatus.
Agrobacterium tumefaciens-mediated transformation of Aspergillus fumigatus: an efficient tool for insertional mutagenesis and targeted gene disruption.
Aspergillus fumigatus alb1 encodes naphthopyrone synthase when expressed in Aspergillus oryzae.
Aspergillus fumigatus conidial pigment and cAMP signal transduction: significance for virulence.
Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus.
Conidial dihydroxynaphthalene melanin of the human pathogenic fungus Aspergillus fumigatus interferes with the host endocytosis pathway.
Conidiation color mutants of Aspergillus fumigatus are highly pathogenic to the heterologous insect host Galleria mellonella.
Cutaneous model of invasive aspergillosis.
Efficient downregulation of alb1 gene using an AMA1-based episomal expression of RNAi construct in Aspergillus fumigatus.
Gene silencing with RNA interference in the human pathogenic fungus Aspergillus fumigatus.
Highly efficient CRISPR mutagenesis by microhomology-mediated end joining in Aspergillus fumigatus.
Identification of Aspergillus fumigatus surface components that mediate interaction of conidia and hyphae with human platelets.
Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence.
Melanin dependent survival of Apergillus fumigatus conidia in lung epithelial cells.
Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidia.
PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus conidia by human monocyte-derived macrophages.
Pentaketide melanin biosynthesis in Aspergillus fumigatus requires chain-length shortening of a heptaketide precursor.
Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling.
Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus.
Role of laeA in the regulation of alb1, gliP, conidial morphology, and virulence in Aspergillus fumigatus.
Subcellular compartmentalization and trafficking of the biosynthetic machinery for fungal melanin.
Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response.
The developmentally regulated alb1 gene of Aspergillus fumigatus: its role in modulation of conidial morphology and virulence.
Virulence determinants of the human pathogenic fungus Aspergillus fumigatus protect against soil amoeba predation.
Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer.
Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites.
LaeA, a regulator of morphogenetic fungal virulence factors.
LaeA, a regulator of secondary metabolism in Aspergillus spp.
Transcriptomic and morphological profiling of Aspergillus fumigatus Af293 in response to antifungal activity produced by Lactobacillus plantarum 16.
Woronin bodies, their impact on stress resistance and virulence of the pathogenic mould Aspergillus fumigatus and their anchoring at the septal pore of filamentous Ascomycota.
Recombinant Aspergillus fumigatus allergens: from the nucleotide sequences to clinical applications.