Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima.
The genome organization of Thermotoga maritima reflects its lifestyle.
Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution.
Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima.
Homo-dimeric recombinant dihydrofolate reductase from Thermotoga maritima shows extreme intrinsic stability.
The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability.
The dihydrofolate reductase-encoding gene dyrA of the hyperthermophilic bacterium Thermotoga maritima.
Structure of PAS-linked histidine kinase and the response regulator complex.
Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643.
Active site metal occupancy and cyclic di-GMP phosphodiesterase activity of Thermotoga maritima HD-GYP.
Tagaturonate-fructuronate epimerase UxaE, a novel enzyme in the hexuronate catabolic network in Thermotoga maritima.
Both DNA gyrase and reverse gyrase are present in the hyperthermophilic bacterium Thermotoga maritima.
The DNA-dependent RNA-polymerase of Thermotoga maritima; characterisation of the enzyme and the DNA-sequence of the genes for the large subunits.
The organization and expression of essential transcription translation component genes in the extremely thermophilic eubacterium Thermotoga maritima.
Cryoelectron microscopy structure and mechanism of the membrane-associated electron-bifurcating flavoprotein Fix/EtfABCX.
Phylogenetic depth of S10 and spc operons: cloning and sequencing of a ribosomal protein gene cluster from the extremely thermophilic bacterium Thermotoga maritima.
Lactate dehydrogenase from the extreme thermophile Thermotoga maritima.
Lactate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima: the crystal structure at 2.1-A resolution reveals strategies for intrinsic protein stabilization.
The L-lactate dehydrogenase gene of the hyperthermophilic bacterium Thermotoga maritima cloned by complementation in Escherichia coli.
ATP-dependent 6-phosphofructokinase from the hyperthermophilic bacterium Thermotoga maritima: characterization of an extremely thermophilic, allosterically regulated enzyme.
Thermotoga maritima phosphofructokinases: expression and characterization of two unique enzymes.
Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV.
Acta Crystallogr. F Struct. Biol. Commun.
A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima.
Development of a Protein Scaffold for Arginine Sensing Generated through the Dissection of the Arginine-Binding Protein from Thermotoga maritima.
Domain communication in Thermotoga maritima Arginine Binding Protein unraveled through protein dissection.
Domain swapping dissection in Thermotoga maritima arginine binding protein: How structural flexibility may compensate destabilization.
Guanidinium binding to proteins: The intriguing effects on the D1 and D2 domains of Thermotoga maritima Arginine Binding Protein and a comprehensive analysis of the Protein Data Bank.
The characterization of Thermotoga maritima Arginine Binding Protein variants demonstrates that minimal local strains have an important impact on protein stability.
The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima.
Structure of the inositol-1-phosphate cytidylyltransferase from Thermotoga maritima.
An NMR approach to structural proteomics.
A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases.
Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases.
Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling.
Structural insight into partner specificity and phosphoryl transfer in two-component signal transduction.
Structure of the entire cytoplasmic portion of a sensor histidine-kinase protein.
Visualizing autophosphorylation in histidine kinases.
Properties of an alpha-galactosidase, and structure of its gene galA, within an alpha- and beta-galactoside utilization gene cluster of the hyperthermophilic bacterium Thermotoga maritima.
Structure of FliM provides insight into assembly of the switch complex in the bacterial flagella motor.
Structure of flagellar motor proteins in complex allows for insights into motor structure and switching.
Thermotoga maritima ribonuclease III. Characterization of thermostable biochemical behavior and analysis of conserved base pairs that function as reactivity epitopes for the Thermotoga 23S rRNA precursor.
The hyperthermophilic bacterium, Thermotoga maritima, contains an unusually complex iron-hydrogenase: amino acid sequence analyses versus biochemical characterization.
The iron-hydrogenase of Thermotoga maritima utilizes ferredoxin and NADH synergistically: a new perspective on anaerobic hydrogen production.
Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion.
Two (betaalpha)(8)-barrel enzymes of histidine and tryptophan biosynthesis have similar reaction mechanisms and common strategies for protecting their labile substrates.
Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima.
The structure of the TsaB/TsaD/TsaE complex reveals an unexpected mechanism for the bacterial t6A tRNA-modification.
Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima.
A novel amylolytic enzyme from Thermotoga maritima, resembling cyclodextrinase and alpha-glucosidase, that liberates glucose from the reducing end of the substrates.
NMR structure determination of the conserved hypothetical protein TM1816 from Thermotoga maritima.
Crystal structures of glycoside hydrolase family 51 alpha-L-arabinofuranosidase from Thermotoga maritima.
Structural analysis of alpha-L-arabinofuranosidase from Thermotoga maritima reveals characteristics for thermostability and substrate specificity.
High-resolution structure of RNase P protein from Thermotoga maritima.
Crystal structure of the SMC head domain: an ABC ATPase with 900 residues antiparallel coiled-coil inserted.
Molecular architecture of SMC proteins and the yeast cohesin complex.
MreB and MurG as scaffolds for the cytoplasmic steps of peptidoglycan biosynthesis.
The Crystal Structure of Thermotoga maritima Class III Ribonucleotide Reductase Lacks a Radical Cysteine Pre-Positioned in the Active Site.
The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant.
Novel inositol catabolic pathway in Thermotoga maritima.
Bacterial actin MreB assembles in complex with cell shape protein RodZ.
Fructose-6-phosphate aldolase is a novel class I aldolase from Escherichia coli and is related to a novel group of bacterial transaldolases.
Structure of the sodium-dependent phosphate transporter reveals insights into human solute carrier SLC20.
Primordial-like enzymes from bacteria with reduced genomes.
Structural basis of catalysis and substrate recognition by the NAD(H)-dependent alpha-d-glucuronidase from the glycoside hydrolase family 4.
Structure of an alpha-glucuronidase in complex with Co2+ and citrate provides insights into the mechanism and substrate recognition in the family 4 glycosyl hydrolases.
Structure of an alpha-glucuronidase in complex with Copisup>2+pi/sup> and citrate provides insights into the mechanism and substrate recognition in the family 4 glycosyl hydrolases.
Flexibility, conformational diversity and two dimerization modes in complexes of ribosomal protein L12.
Heptameric (L12)6/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria.
Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation.
Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima.
Hyperthermostable acetyl xylan esterase.
The structural basis for the narrow substrate specificity of an acetyl esterase from Thermotoga maritima.
Structure of a D-tagatose 3-epimerase-related protein from the hyperthermophilic bacterium Thermotoga maritima.
TM0416 is a hyperthermophilic promiscuous non-phosphorylated sugar isomerase that catalyzes various C5 and C6 epimerization reactions.
Crystal structure of the cytosolic domain of the cation diffusion facilitator family protein.
Structural and functional characterizations of the C-terminal domains of CzcD proteins.
A thermostable K(+)-stimulated vacuolar-type pyrophosphatase from the hyperthermophilic bacterium Thermotoga maritima.
Large-scale purification of the proton pumping pyrophosphatase from Thermotoga maritima: a 'Hot-Solve' method for isolation of recombinant thermophilic membrane proteins.
Membrane-bound pyrophosphatase of Thermotoga maritima requires sodium for activity.
Na+-pyrophosphatase: a novel primary sodium pump.
Reverse gyrase from the hyperthermophilic bacterium Thermotoga maritima: properties and gene structure.
The structure and catalytic cycle of a sodium-pumping pyrophosphatase.
Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2.85 A resolution.
ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex.
Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair.
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.
Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response.
Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.
Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities.
The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair.
Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme.
Mechanism of 3'-Matured tRNA Discrimination from 3'-Immature tRNA by Class-II CCA-Adding Enzyme.
Metal active site elasticity linked to activation of homocysteine in methionine synthases.
Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase.
Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution.
Discovery of a dipeptide epimerase enzymatic function guided by homology modeling and virtual screening.
Evolution of enzymatic activities in the enolase superfamily: functional assignment of unknown proteins in Bacillus subtilis and Escherichia coli as L-Ala-D/L-Glu epimerases.
Complete amino-acid sequence of glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic eubacterium Thermotoga maritima.
Extremely thermostable D-glyceraldehyde-3-phosphate dehydrogenase from the eubacterium Thermotoga maritima.
Functional expression of D-glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic eubacterium Thermotoga maritima in Escherichia coli. Authenticity and kinetic properties of the recombinant enzyme.
The crystal structure of holo-glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima at 2.5-A resolution.
TM0486 from the hyperthermophilic anaerobe Thermotoga maritima is a thiamin-binding protein involved in response of the cell to oxidative conditions.
Arginine biosynthesis in Thermotoga maritima: characterization of the arginine-sensitive N-acetyl-L-glutamate kinase.
Structural bases of feed-back control of arginine biosynthesis, revealed by the structures of two hexameric N-acetylglutamate kinases, from Thermotoga maritima and Pseudomonas aeruginosa.
(Beta alpha)8-barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritima.
Characterization of dihydrodipicolinate reductase from Thermotoga maritima reveals evolution of substrate binding kinetics.
Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain.
Differential Substrate Recognition by Maltose Binding Proteins Influenced by Structure and Dynamics.
Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 A resolution.
Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation.
Systematic discovery of analogous enzymes in thiamin biosynthesis.
Structure of an iminosugar complex of a glycoside hydrolase family 5 lichenase provides insights into the active site.
How metal cofactors drive dimer-dodecamer transition of the M42 aminopeptidase TmPep1050 of Thermotoga maritima.
M42 aminopeptidase catalytic site: the structural and functional role of a strictly conserved aspartate residue.
X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050.
Structure and function of an unusual family of protein phosphatases: the bacterial chemotaxis proteins CheC and CheX.
Characterization and structural modeling of a new type of thermostable esterase from Thermotoga maritima.
Identification of methylation sites in Thermotoga maritima chemotaxis receptors.
Crystal structure of YlqF, a circularly permuted GTPase: implications for its GTPase activation in 50 S ribosomal subunit assembly.
Structural characterization of the putative ABC-type 2 transporter from Thermotoga maritima MSB8.
Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold.
Crystal structure of Thermotoga maritima 0065, a member of the IclR transcriptional factor family.
Importance of hydrogen bonding in fine tuning the [2Fe-2S] cluster redox potential of HydC from Thermotoga maritima.
NMR structure determination of the hypothetical protein TM1290 from Thermotoga maritima using automated NOESY analysis.
Isolation and analysis of genes for amylolytic enzymes of the hyperthermophilic bacterium Thermotoga maritima.
Assembly and mechanism of a group II ECF transporter.
The crystal structure of a hyperthermostable subfamily II isocitrate dehydrogenase from Thermotoga maritima.
Characterization of an ancestral type of pyruvate ferredoxin oxidoreductase from the hyperthermophilic bacterium, Thermotoga maritima.
Purification and characterization of Thermotoga maritima homoserine transsuccinylase indicates it is a transacetylase.
Structural basis of the substrate subsite and the highly thermal stability of xylanase 10B from Thermotoga maritima MSB8.
The crystal structure of apo-FtsH reveals domain movements necessary for substrate unfolding and translocation.
The molecular architecture of the metalloprotease FtsH.
Cloning, overexpression, purification, and physicochemical characterization of a cold shock protein homolog from the hyperthermophilic bacterium Thermotoga maritima.
Does the elimination of ion pairs affect the thermal stability of cold shock protein from the hyperthermophilic bacterium Thermotoga maritima?
Solution NMR structure of the cold-shock protein from the hyperthermophilic bacterium Thermotoga maritima.
Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77-A resolution.
Analysis of the gene for beta-fructosidase (invertase, inulinase) of the hyperthermophilic bacterium Thermotoga maritima, and characterisation of the enzyme expressed in Escherichia coli.
Crystal structure of inactivated Thermotoga maritima invertase in complex with the trisaccharide substrate raffinose.
The three-dimensional structure of invertase (beta-fructosidase) from Thermotoga maritima reveals a bimodular arrangement and an evolutionary relationship between retaining and inverting glycosidases.
Characterization of multi-functional properties and conformational analysis of MutS2 from Thermotoga maritima MSB8.
Cloning, sequencing, and expression of RecA proteins from three distantly related thermophilic eubacteria.
Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 A resolution.
Crystal structure of a PhoU protein homologue: a new class of metalloprotein containing multinuclear iron clusters.
Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase.
Isolation and cloning of Omp alpha, a coiled-coil protein spanning the periplasmic space of the ancestral eubacterium Thermotoga maritima.
Improved interface packing and design opportunities revealed by CryoEM analysis of a designed protein nanocage.
A novel member of the YchN-like fold: solution structure of the hypothetical protein Tm0979 from Thermotoga maritima.
NMR structure of the conserved hypothetical protein TM0979 from Thermotoga maritima.
Cryo-EM Structure of Heterologous Protein Complex Loaded Thermotoga Maritima Encapsulin Capsid.
Identification of a Minimal Peptide Tag for in Vivo and in Vitro Loading of Encapsulin.
Pore Engineering for Enhanced Mass Transport in Encapsulin Nanocompartments.
Structural basis of enzyme encapsulation into a bacterial nanocompartment.
The encapsulin from Thermotoga maritima is a flavoprotein with a symmetry matched ferritin-like cargo protein.
Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold.
A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation.
Elucidation of the D-lysine biosynthetic pathway in the hyperthermophile Thermotoga maritima.
Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains.
Ligands of Thermophilic ABC Transporters Encoded in a Newly Sequenced Genomic Region of Thermotoga maritima MSB8 Screened by Differential Scanning Fluorimetry.
A survey of polypeptide deformylase function throughout the eubacterial lineage.
Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family.
Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity.
Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase.
Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima.
Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotogamaritima.
Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution.
Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis.
Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 A resolution reveals a new fold.
Molecular identification of pseudouridine-metabolizing enzymes.
The hyperthermophilic bacterium Thermotoga maritima has two different classes of family C DNA polymerases: evolutionary implications.
MiaB protein from Thermotoga maritima. Characterization of an extremely thermophilic tRNA-methylthiotransferase.
MiaB protein is a bifunctional radical-S-adenosylmethionine enzyme involved in thiolation and methylation of tRNA.
MiaB, a bifunctional radical-S-adenosylmethionine enzyme involved in the thiolation and methylation of tRNA, contains two essential [4Fe-4S] clusters.
A unique beta-1,2-mannosyltransferase of Thermotoga maritima that uses di-myo-inositol phosphate as the mannosyl acceptor.
Preparative enzymatic synthesis of polyprenyl-pyrophosphoryl-Nacetylglucosamine, an essential lipid intermediate for the biosynthesis of various bacterial cell envelope polymers.
Purification and characterization of the bacterial UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase WecA.
Mutational analysis of endonuclease V from Thermotoga maritima.
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair.
The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway.
Acta Crystallogr Sect F Struct Biol Cryst Commun
Crystal structure of the tRNA 3' processing endoribonuclease tRNase Z from Thermotoga maritima.
The structure of the flexible arm of Thermotoga maritima tRNase Z differs from those of homologous enzymes.
Crystal structure of the middle and C-terminal domains of the flagellar rotor protein FliG.
Structural insight into the rotational switching mechanism of the bacterial flagellar motor.
Structural insights into the interaction between the bacterial flagellar motor proteins FliF and FliG.
Structure of the C-terminal domain of FliG, a component of the rotor in the bacterial flagellar motor.
Crystal structures of the antitermination factor NusB from Thermotoga maritima and implications for RNA binding.
Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution.
Structure of a complex of the ATPase SecA and the protein-translocation channel.
Isolation and analysis of a gene encoding alpha-glucuronidase, an enzyme with a novel primary structure involved in the breakdown of xylan.
Identification of an intermediate methyl carrier in the radical S-adenosylmethionine methylthiotransferases RimO and MiaB.
Post-translational modification of ribosomal proteins: structural and functional characterization of RimO from Thermotoga maritima, a radical S-adenosylmethionine methylthiotransferase.
Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases.
Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1.7 A resolution.
Structure-based activity prediction for an enzyme of unknown function.
The 1.59 A resolution crystal structure of TM0096, a flavin mononucleotide binding protein from Thermotoga maritima.
Sequence, assembly and evolution of a primordial ferredoxin from Thermotoga maritima.
Phylogenetic analysis of sequences from diverse bacteria with homology to the Escherichia coli rho gene.
The structure of RNA-free Rho termination factor indicates a dynamic mechanism of transcript capture.
Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria.
An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA.
Crystal structure of NusA from Thermotoga maritima and functional implication of the N-terminal domain.
NMR solution structure of Thermotoga maritima protein TM1509 reveals a Zn-metalloprotease-like tertiary structure.
Comparison of NMR and crystal structures for the proteins TM1112 and TM1367.
Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold.
On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171.
Insights into Flavin-based Electron Bifurcation via the NADH-dependent Reduced Ferredoxin:NADP Oxidoreductase Structure.
Comparative analysis of pyruvate kinases from the hyperthermophilic archaea Archaeoglobus fulgidus, Aeropyrum pernix, and Pyrobaculum aerophilum and the hyperthermophilic bacterium Thermotoga maritima: unusual regulatory properties in hyperthermophilic archaea.
Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily.
Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution.
Structure and activity of the flagellar rotor protein FliY: a member of the CheC phosphatase family.
The crystal structure of a hyperthermoactive exopolygalacturonase from Thermotoga maritima reveals a unique tetramer.
Co-Folding of a FliF-FliG Split Domain Forms the Basis of the MS:C Ring Interface within the Bacterial Flagellar Motor.
A highly active protein repair enzyme from an extreme thermophile: the L-isoaspartyl methyltransferase from Thermotoga maritima.
Crystal structure of protein isoaspartyl methyltransferase. A catalyst for protein repair.
Thermostable chemotaxis proteins from the hyperthermophilic bacterium Thermotoga maritima.
Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution.
Structural analysis of a set of proteins resulting from a bacterial genomics project.
The 3.2 A resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays.
The structure of a soluble chemoreceptor suggests a mechanism for propagating conformational signals.
Crystal structure of TM1030 from Thermotoga maritima at 2.3 A resolution reveals molecular details of its transcription repressor function.
Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment.
In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima?
Purification, crystallization and preliminary X-ray diffraction analysis of the putative ABC transporter ATP-binding protein from Thermotoga maritima.
Comparative anatomy of a regulatory ribosomal protein.
Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon.
Evolutionary relationship of two ancient protein superfolds.
A structural basis for Mg2+ homeostasis and the CorA translocation cycle.
Co2+ selectivity of Thermotoga maritima CorA and its inability to regulate Mg2+ homeostasis present a new class of CorA proteins.
Cryo-EM Structures of the magnesium channel CorA reveal symmetry break upon gating.
Crystal structure of a divalent metal ion transporter CorA at 2.9 Angstrom resolution.
Crystal structure of the CorA Mg2+ transporter.
Exploring the structure and function of Thermotoga maritima CorA reveals the mechanism of gating and ion selectivity in Co2+/Mg2+ transport.
Probing structure-function relationships and gating mechanisms in the CorA Mg2+ transport system.
Structural asymmetry in the magnesium channel CorA points to sequential allosteric regulation.
Structural insights into the mechanisms of Mg2+ uptake, transport, and gating by CorA.
The periplasmic loop provides stability to the open state of the CorA magnesium channel.
Why is the GMN motif conserved in the CorA/Mrs2/Alr1 superfamily of magnesium transport proteins?
Nucleotide sequence of the gene coding for the elongation factor Tu from the extremely thermophilic eubacterium Thermotoga maritima.
Phylogenetic depth of Thermotoga maritima inferred from analysis of the fus gene: amino acid sequence of elongation factor G and organization of the Thermotoga str operon.
Characterization of the full length uracil-DNA glycosylase in the extreme thermophile Thermotoga maritima.
Thermostable uracil-DNA glycosylase from Thermotoga maritima a member of a novel class of DNA repair enzymes.
Structure and mechanism of the RuvB Holliday junction branch migration motor.
Cloning and sequencing of the gene coding for topoisomerase I from the extremely thermophilic eubacterium, Thermotoga maritima.
Crystal structure of the cell division protein FtsA from Thermotoga maritima.
Structural insights into the mechanism of the PLP synthase holoenzyme from Thermotoga maritima.
Cryo-EM structure of a thermostable bacterial nanocompartment.
Encapsulin Nanocontainers as Versatile Scaffolds for the Development of Artificial Metabolons.
Homomultimeric protease and putative bacteriocin homolog from Thermotoga maritima.
Homomultimeric protease in the hyperthermophilic bacterium Thermotoga maritima has structural and amino acid sequence homology to bacteriocins in mesophilic bacteria.
Large-scale computational discovery and analysis of virus-derived microbial nanocompartments.
Pore structure controls stability and molecular flux in engineered protein cages.
Duplication of genes in an ATP-binding cassette transport system increases dynamic range while maintaining ligand specificity.
Crystal structure of Thermotoga maritima 4-alpha-glucanotransferase and its acarbose complex: implications for substrate specificity and catalysis.
Purification and characterization of a novel thermostable 4-alpha-glucanotransferase of Thermotoga maritima cloned in Escherichia coli.
Comparative amino acid sequence analysis of Thermotoga maritima beta-glucosidase (BglA) deduced from the nucleotide sequence of the gene indicates distant relationship between beta-glucosidases of the BGA family and other families of beta-1,4-glycosyl hydrolases.
A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products.
Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination.
Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures.
Crystal structure of a flavin-binding protein from Thermotoga maritima.
Crystal structure of flavin binding to FAD synthetase of Thermotoga maritima.
An NMR-derived model for the solution structure of oxidized Thermotoga maritima 1[Fe4-S4] ferredoxin.
Small structural changes account for the high thermostability of 1[4Fe-4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima.
Structure of CheA, a signal-transducing histidine kinase.
Crystal structure of an ADP-ribosylated protein with a cytidine deaminase-like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 A resolution.
An essential GTPase, der, containing double GTP-binding domains from Escherichia coli and Thermotoga maritima.
Domain arrangement of Der, a switch protein containing two GTPase domains.
Structural and functional characterization of the hydrogenase-maturation HydF protein.
A gyrB-like gene from the hyperthermophilic bacterion Thermotoga maritima.
Glycerate 2-kinase of Thermotoga maritima and genomic reconstruction of related metabolic pathways.
Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p.
An autoinhibited state in the structure of Thermotoga maritima NusG.
Synthetic symmetrization in the crystallization and structure determination of CelA from Thermotoga maritima.
Histidine ligand variants of a flavo-diiron protein: effects on structure and activities.
A novel mode of dimerization via formation of a glutamate anhydride crosslink in a protein crystal structure.
Structures along the catalytic pathway of PrmC/HemK, an N5-glutamine AdoMet-dependent methyltransferase.
X-ray crystallographic studies of HemK from Thermotoga maritima, an N5-glutamine methyltransferase.
Imidazole glycerol phosphate synthase from Thermotoga maritima. Quaternary structure, steady-state kinetics, and reaction mechanism of the bienzyme complex.
Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex.
The structural basis of substrate promiscuity in UDP-hexose 4-epimerase from the hyperthermophilic Eubacterium Thermotoga maritima.
Crystal structure of the protease domain of a heat-shock protein HtrA from Thermotoga maritima.
Characterization of GTPase activity of TrmE, a member of a novel GTPase superfamily, from Thermotoga maritima.
The structure of the TrmE GTP-binding protein and its implications for tRNA modification.
Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634.
NMR assignments of the cold-shock protein ribosome-binding factor A (RbfA) from Thermotoga maritima.
Identification and biochemical characterization of threonine dehydratase from the hyperthermophile Thermotoga maritima.
Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron sulphur cluster assembly.
A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer.
The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity.
Structure of a NAD kinase from Thermotoga maritima at 2.3 A resolution.
Preliminary X-ray crystallographic analysis of tRNA pseudouridine 55 synthase from the thermophilic eubacterium Thermotoga maritima.
Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit.
Octameric enolase from the hyperthermophilic bacterium Thermotoga maritima: purification, characterization, and image processing.
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline.
A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats.
TM1385 from Thermotoga maritima functions as a phosphoglucose isomerase via cis-enediol-based mechanism with active site redundancy.
Biochemical analysis of Thermotoga maritima GH36 alpha-galactosidase (TmGalA) confirms the mechanistic commonality of clan GH-D glycoside hydrolases.
Improvement of the efficiency of transglycosylation catalyzed by alpha-galactosidase from Thermotoga maritima by protein engineering.
Structural snapshots for mechanism-based inactivation of a glycoside hydrolase by cyclopropyl carbasugars.
The method of integrated kinetics and its applicability to the exo-glycosidase-catalyzed hydrolysis of p-nitrophenyl glycosides.
alpha-Galactobiosyl units: thermodynamics and kinetics of their formation by transglycosylations catalysed by the GH36 alpha-galactosidase from Thermotoga maritima.
Phylogenetic analyses of two 'archaeal' genes in thermotoga maritima reveal multiple transfers between archaea and bacteria.
Predicted role for the archease protein family based on structural and sequence analysis of TM1083 and MTH1598, two proteins structurally characterized through structural genomics efforts.
Ligand-induced conformational changes in a thermophilic ribose-binding protein.
Structures of permuted halves of a modern ribose-binding protein.
Identification of a novel cellulose-binding domain within the multidomain 120 kDa xylanase XynA of the hyperthermophilic bacterium Thermotoga maritima.
Structural analysis of a periplasmic binding protein in the tripartite ATP-independent transporter family reveals a tetrameric assembly that may have a role in ligand transport.
Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure.
Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes.
Conformational flexibility and peptide interaction of the translocation ATPase SecA.
Sequential aldol condensation catalyzed by hyperthermophilic 2-deoxy-d-ribose-5-phosphate aldolase.
Evidence of intradomain and interdomain flexibility in an OmpR/PhoB homolog from Thermotoga maritima.
Regulation of response regulator autophosphorylation through interdomain contacts.
Structural and biochemical characterization of FabK from Thermotoga maritima.
A di-iron protein recruited as an Fe[II] and oxygen sensor for bacterial chemotaxis functions by stabilizing an iron-peroxy species.
X-ray structures of threonine aldolase complexes: structural basis of substrate recognition.
Crystal structure of a hypothetical protein, TM841 of Thermotoga maritima, reveals its function as a fatty acid-binding protein.
Crystal structure of glutamine amidotransferase from Thermotoga maritima.
Identification of genes encoding ribosomal protein L33 from Bacillus licheniformis, Thermus thermophilus and Thermotoga maritima.
Cloning, sequencing, and expression of ruvB and characterization of RuvB proteins from two distantly related thermophilic eubacteria.
Characterization of glycosyl hydrolase family 3 beta-N-acetylglucosaminidases from Thermotoga maritima and Thermotoga neapolitana.
The structure of hyperthermophilic beta-N-acetylglucosaminidase reveals a novel dimer architecture associated with the active site.
Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold.
Crystal structure of Thermotoga maritima alpha-glucosidase AglA defines a new clan of NAD+-dependent glycosidases.
Identification of residues important for NAD+ binding by the Thermotoga maritima alpha-glucosidase AglA, a member of glycoside hydrolase family 4.
Thermotoga maritima AglA, an extremely thermostable NAD+-, Mn2+-, and thiol-dependent alpha-glucosidase.
A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter.
Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation.
Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.
The extracellular gate shapes the energy profile of an ABC exporter.
Enzyme genomics: application of general enzymatic screens to discover new enzymes.
Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5 A resolution.
Structural and biochemical characterization of the beta-N-acetylglucosaminidase from Thermotoga maritima: toward rationalization of mechanistic knowledge in the GH73 family.
Altering the Phosphorylation Position of Pyrophosphate-Dependent myo-Inositol-1-Kinase Based on Its Crystal Structure.
Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants.
Crystal structure of TM1457 from Thermotoga maritima.
Bacterial phylogeny based on comparative sequence analysis.
Reconstruction of the chemotaxis receptor-kinase assembly.
A detailed view of a ribosomal active site: the structure of the L11-RNA complex.
Crystallization and preliminary X-ray crystallographic characterization of TrmFO, a folate-dependent tRNA methyltransferase from Thermotoga maritima.
Crystal structures of quinolinate synthase in complex with a substrate analogue, the condensation intermediate, and substrate-derived product.
Crystallographic trapping of reaction intermediates in quinolinic acid synthesis by NadA.
Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.
The crystal structure of FeS quinolinate synthase unravels an enzymatic dehydration mechanism that uses tyrosine and a hydrolase-type triad.
Crystal structure of Thermotoga maritima ribosome recycling factor: a tRNA mimic.
Thermostability, oligomerization and DNA-binding properties of the regulatory protein ArgR from the hyperthermophilic bacterium Thermotoga neapolitana.
Biochemical characterization of the HydE and HydG iron-only hydrogenase maturation enzymes from Thermatoga maritima.
Unexpected electron transfer mechanism upon AdoMet cleavage in radical SAM proteins.
X-ray snapshots of possible intermediates in the time course of synthesis and degradation of protein-bound Fe4S4 clusters.
X-ray structure of the [FeFe]-hydrogenase maturase HydE from Thermotoga maritima.
Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold.
Crystal structure at 2.0-A resolution of phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga maritima: possible determinants of protein stability.
Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.05 A resolution.
An unusual mechanism of glycoside hydrolysis involving redox and elimination steps by a family 4 beta-glycosidase from Thermotoga maritima.
NAD(+) and metal-ion dependent hydrolysis by family 4 glycosidases: structural insight into specificity for phospho-beta-D-glucosides.
Root of the universal tree of life based on ancient aminoacyl-tRNA synthetase gene duplications.
Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization.
Dihydrodipicolinate synthase from Thermotoga maritima.
Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 A resolution.
X-ray crystal structure of CutA from Thermotoga maritima at 1.4 A resolution.
Structural studies of the catalytic reaction pathway of a hyperthermophilic histidinol-phosphate aminotransferase.
Conformational communication mediates the reset step in t6A biosynthesis.
Assembly and stoichiometry of the core structure of the bacterial flagellar type III export gate complex.
Characterization of a [2Fe-2S] protein encoded in the iron-hydrogenase operon of Thermotoga maritima.
Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 A resolution reveals a new fold.
Crystal structures of TM0549 and NE1324--two orthologs of E. coli AHAS isozyme III small regulatory subunit.
Crystal structure of full length topoisomerase I from Thermotoga maritima.
Prokaryotic origin of the actin cytoskeleton.
PDB-UF: database of predicted enzymatic functions for unannotated protein structures from structural genomics.
Crystal structures of CheY from Thermotoga maritima do not support conventional explanations for the structural basis of enhanced thermostability.
Crystal structure of a transcription regulator (TM1602) from Thermotoga maritima at 2.3 A resolution.
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon.
Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication.
Crystal structure of YjeQ from Thermotoga maritima contains a circularly permuted GTPase domain.
Structural basis for dimer formation of the CRISPR-associated protein Csm2 of Thermotoga maritima.
Biochemical characterization and crystal structure of endoglucanase Cel5A from the hyperthermophilic Thermotoga maritima.
Diverse substrate recognition mechanism revealed by Thermotoga maritima Cel5A structures in complex with cellotetraose, cellobiose and mannotriose.
Thermotoga maritima MazG protein has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities.
Crystal structure of an UDP-N-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3-A resolution.
Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase: the ancestral eubacterial DAHP synthase?
An enzymatic activation of formaldehyde for nucleotide methylation.
An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution.
Deprotonations in the reaction of flavin-dependent thymidylate synthase.
Diffraction study of protein crystals grown in cryoloops and micromounts.
Flavin-dependent thymidylate synthase as a drug target for deadly microbes: mutational study and a strategy for inhibitor design.
Folate binding site of flavin-dependent thymidylate synthase.
Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein.
The glnA gene of the extremely thermophilic eubacterium Thermotoga maritima: cloning, primary structure, and expression in Escherichia coli.
Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 A resolution.
Molecular and biochemical characterization of the thermoactive family 1 pectate lyase from the hyperthermophilic bacterium Thermotoga maritima.
Closed structure of phosphoglycerate kinase from Thermotoga maritima reveals the catalytic mechanism and determinants of thermal stability.
Phosphoglycerate kinase and triosephosphate isomerase from the hyperthermophilic bacterium Thermotoga maritima form a covalent bifunctional enzyme complex.
The crystal structure of triosephosphate isomerase (TIM) from Thermotoga maritima: a comparative thermostability structural analysis of ten different TIM structures.
Identification and sequencing of the Thermotoga maritima lacZ gene, part of a divergently transcribed operon.
FtsZ from Escherichia coli, Azotobacter vinelandii, and Thermotoga maritima -- quantitation, GTP hydrolysis, and assembly.
Structural insights into FtsZ protofilament formation.
Characterization of a tetrameric inositol monophosphatase from the hyperthermophilic bacterium Thermotoga maritima.
Crystal structure of the tetrameric inositol 1-phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima.
MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase.
Discovery of a new prokaryotic type I GTP cyclohydrolase family.
Crystal structure of glutamate dehydrogenase from the hyperthermophilic eubacterium Thermotoga maritima at 3.0-A resolution.
Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. I. Introduction of a six-residue ion-pair network in the hinge region.
Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. II: construction of a 16-residue ion-pair network at the subunit interface.
Glutamate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima: molecular characterization and phylogenetic implications.
Structural basis of novel interactions between the small-GTPase and GDI-like domains in prokaryotic FeoB iron transporter.
Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 A resolution.
A Well-Defined Osmium-Cupin Complex: Hyperstable Artificial Osmium Peroxygenase.
An artificial metallolyase with pliable 2-His-1-carboxylate facial triad for stereoselective Michael addition.
Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 A resolution.
Cupin Variants as a Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes.
Nonredox thiolation in tRNA occurring via sulfur activation by a [4Fe-4S] cluster.