Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.
Amplification of the entire kanamycin biosynthetic gene cluster during empirical strain improvement of Streptomyces kanamyceticus.
The kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus.
The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the alpha-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK.
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
Cloning of antibiotic-resistance genes in Streptomyces.
Mechanisms of aminoglycoside-resistance of Streptomyces harboring resistant genes obtained from antibiotic-producers.
Functional characterization of kanB by complementing in engineered Streptomyces fradiae Deltaneo6::tsr.
Biochemical and Structural Analysis of a Dehydrogenase, KanD2, and an Aminotransferase, KanS2, That Are Responsible for the Construction of the Kanosamine Moiety in Kanamycin Biosynthesis.