Aromatic amino acid family biosynthetic process
D-arabinono-1,4-lactone oxidase activity
nucleobase transmembrane transporter activity
purine nucleobase transmembrane transport
DNA-binding transcription factor activity
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
acyltransferase activity, transferring groups other than amino-acyl groups
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
DNA-(apurinic or apyrimidinic site) endonuclease activity
oxidized purine nucleobase lesion DNA N-glycosylase activity
hydrolase activity, hydrolyzing O-glycosyl compounds
pyridoxine 5'-phosphate synthase activity
5-amino-6-(5-phosphoribosylamino)uracil reductase activity
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
regulation of DNA-templated transcription
5-oxoprolinase (ATP-hydrolyzing) activity
oxidoreductase activity, acting on CH-OH group of donors
mannose-1-phosphate guanylyltransferase (GTP) activity
proteolysis involved in protein catabolic process
N-acetyl-beta-D-galactosaminidase activity
translation release factor activity, codon specific
[acyl-carrier-protein] S-malonyltransferase activity
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
phosphate-containing compound metabolic process
RNA polymerase II transcription regulatory region sequence-specific DNA binding
purine-rich negative regulatory element binding
negative regulation of ribosome biogenesis
glycine decarboxylation via glycine cleavage system
histidinol-phosphate transaminase activity
ATPase-coupled monoatomic cation transmembrane transporter activity
glucose-fructose oxidoreductase activity
S-adenosylmethionine-dependent methyltransferase activity
tRNA-guanosine(34) queuine transglycosylase activity
cellular aromatic compound metabolic process
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
efflux transmembrane transporter activity
oxidoreductase activity, acting on the CH-CH group of donors
vinylacetyl-CoA delta-isomerase activity
lysine biosynthetic process via diaminopimelate
succinate-CoA ligase (ADP-forming) activity
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
rRNA (cytosine-2'-O-)-methyltransferase activity
protoporphyrinogen IX biosynthetic process
5-(carboxyamino)imidazole ribonucleotide mutase activity
5-amino-4-imidazole carboxylate lyase activity
phosphoribosylaminoimidazole carboxylase activity
1,4-alpha-glucan branching enzyme activity
1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)
alpha-N-acetylgalactosaminidase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
7,8-dihydroneopterin 3'-triphosphate biosynthetic process
Nicotinamide adenine dinucleotide phosphate
Nicotinic adenine dinucleotide phosphate
4-hydroxy-tetrahydrodipicolinate reductase
oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
phosphorelay response regulator activity
phosphoadenylyl-sulfate reductase (thioredoxin) activity
sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
O-phospho-L-serine:2-oxoglutarate aminotransferase activity
glucomannan 4-beta-mannosyltransferase activity
uroporphyrin-III C-methyltransferase activity
N-acylneuraminate cytidylyltransferase activity
monoatomic anion transmembrane transporter activity
mechanosensitive monoatomic ion channel activity
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
di-trans,poly-cis-decaprenylcistransferase activity
protein transmembrane transporter activity
negative regulation of DNA-templated transcription
cytosine transmembrane transporter activity
sugar transmembrane transporter activity
P450-containing electron transport chain
uroporphyrinogen III biosynthetic process
ATP synthesis coupled electron transport
NADH dehydrogenase (ubiquinone) activity
site-specific DNA-methyltransferase (adenine-specific) activity
Adenosine 5'-triphosphate biosynthetic process
Adenosine triphosphate biosynthetic process
Proton-transporting ATP synthase complex coupling factor F(0)
proton-transporting ATP synthase activity, rotational mechanism
proton-transporting ATP synthase complex, coupling factor F(o)
nicotinate-nucleotide diphosphorylase (carboxylating) activity
polysaccharide transmembrane transporter activity
oligopeptide transmembrane transporter activity
extracellular polysaccharide biosynthetic process
non-membrane spanning protein tyrosine kinase activity
L-glutamine:2-oxoglutarate aminotransferase activity
glutamine-scyllo-inositol transaminase activity
peptidoglycan beta-N-acetylmuramidase activity
nucleoside triphosphate diphosphatase activity
long-chain fatty acid luciferin component ligase activity
leukotriene C4 gamma-glutamyl transferase activity
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
glycine dehydrogenase (decarboxylating) activity
UDP-N-acetylmuramate-L-alanine ligase activity
carbohydrate derivative metabolic process
caffeoyl-CoA O-methyltransferase activity
DNA-directed 5'-3' RNA polymerase activity
3-carboxy-cis,cis-muconate cycloisomerase activity
crossover junction DNA endonuclease activity
long-chain fatty acid-CoA ligase activity
L-threonine catabolic process to glycine
(R)-benzylsuccinyl-CoA dehydrogenase activity
pyrroline-5-carboxylate reductase activity
hydrolase activity, acting on glycosyl bonds
malate dehydrogenase (decarboxylating) (NAD+) activity
phosphoribosylformylglycinamidine synthase activity
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
hydrolase activity, acting on ester bonds
tRNA threonylcarbamoyladenosine modification
phosphotransferase activity, for other substituted phosphate groups
P-type potassium transmembrane transporter activity
pantetheine-phosphate adenylyltransferase activity
type I site-specific deoxyribonuclease activity
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
glycerol-3-phosphate dehydrogenase complex
monoatomic cation transmembrane transporter activity
asparagine synthase (glutamine-hydrolyzing) activity
Molybdenum cofactor biosynthetic process
Mo-molybdopterin cofactor biosynthetic process
enzyme-directed rRNA pseudouridine synthesis
Proton-transporting ATP synthase complex catalytic core F(1)
proton-transporting ATP synthase complex, catalytic core F(1)
inositol monophosphate 1-phosphatase activity
phosphatidylinositol phosphate biosynthetic process
tetraacyldisaccharide 4'-kinase activity
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity
nicotinate-nucleotide adenylyltransferase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
estradiol 17-beta-dehydrogenase [NAD(P)] activity
indole-3-acetonitrile nitrilase activity
'de novo' L-methionine biosynthetic process
aspartate-semialdehyde dehydrogenase activity
peptidyl-prolyl cis-trans isomerase activity
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
3-methyl-2-oxobutanoate hydroxymethyltransferase activity
beta-lactam antibiotic catabolic process
'de novo' pyrimidine nucleobase biosynthetic process
dihydroorotate dehydrogenase (fumarate) activity
1-pyrroline-5-carboxylate dehydrogenase activity
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
3,4-dihydroxy-2-butanone-4-phosphate synthase activity
succinyl-diaminopimelate desuccinylase activity
xenobiotic detoxification by transmembrane export across the plasma membrane
xenobiotic transmembrane transporter activity
shikimate 3-dehydrogenase (NADP+) activity
glutamate synthase (ferredoxin) activity
D-lactate dehydrogenase (cytochrome) activity
DNA replication, synthesis of RNA primer
DNA unwinding involved in DNA replication
phosphoribosylamine-glycine ligase activity
glucosamine-6-phosphate deaminase activity
ribose phosphate diphosphokinase activity
ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ADP-glyceromanno-heptose 6-epimerase activity
carbamoyl-phosphate synthase (ammonia) activity
racemase and epimerase activity, acting on amino acids and derivatives
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
negative regulation of translational elongation
rRNA (guanine-N7-)-methyltransferase activity
Glc3Man9GlcNAc2 oligosaccharide glucosidase activity
positive regulation of cell cycle G2/M phase transition
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
L-aminoadipate-semialdehyde dehydrogenase activity
DNA topoisomerase type I (single strand cut, ATP-independent) activity
NAD(P)+ transhydrogenase (AB-specific) activity
dihydrolipoyllysine-residue succinyltransferase activity
deoxyribonucleotide biosynthetic process
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
pyridoxine:NADP 4-dehydrogenase activity
glucose 1-dehydrogenase [NAD(P)] activity
tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity
orotate phosphoribosyltransferase activity
4-hydroxy-tetrahydrodipicolinate synthase activity
Branched-chain amino acid biosynthetic process
peptidoglycan glycosyltransferase activity
N-sulfoglucosamine sulfohydrolase activity
outer membrane-bounded periplasmic space
mercury ion transmembrane transporter activity
'de novo' GDP-L-fucose biosynthetic process
ABC-type bacteriocin transporter activity
ATP-binding cassette (ABC) transporter complex
transferase activity, transferring phosphorus-containing groups
gluconate transmembrane transporter activity
thioredoxin-disulfide reductase (NADP) activity
initiator methionyl aminopeptidase activity
protein quality control for misfolded or incompletely synthesized proteins
diphosphate hydrolysis-driven proton transmembrane transporter activity
inorganic diphosphate phosphatase activity
cysteine biosynthetic process from serine
ATP-dependent chromatin remodeler activity
sulfate adenylyltransferase (ATP) activity
acetyl-CoA biosynthetic process from acetate
siderophore-iron transmembrane transporter activity
phosphoribosylglycinamide formyltransferase activity
5-carboxymethyl-2-hydroxymuconate delta-isomerase activity
UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
sodium ion transmembrane transporter activity
biphenyl-2,3-diol 1,2-dioxygenase activity
plasma membrane light-harvesting complex
phosphate:acyl-[acyl carrier protein] acyltransferase activity
imidazoleglycerol-phosphate dehydratase activity
potassium ion transmembrane transporter activity
plasma membrane respiratory chain complex IV
trans-hexaprenyltranstransferase activity
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DNA-binding transcription activator activity
cobalt ion transmembrane transporter activity
magnesium ion transmembrane transporter activity
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
UDP-N-acetylmuramate dehydrogenase activity
4-hydroxythreonine-4-phosphate dehydrogenase activity
L-lactate dehydrogenase (cytochrome) activity
3-oxoacyl-[acyl-carrier-protein] synthase activity
beta-ketoacyl-acyl-carrier-protein synthase III activity
phosphotransferase activity, alcohol group as acceptor
transferase activity, transferring alkyl or aryl (other than methyl) groups
double-stranded DNA 3'-5' DNA exonuclease activity
uracil phosphoribosyltransferase activity
L-aspartate:fumarate oxidoreductase activity
ammonium transmembrane transporter activity
glutaryl-7-aminocephalosporanic-acid acylase activity
calmodulin-dependent protein kinase activity
methylenetetrahydrofolate reductase (NAD(P)H) activity
L-arabinose catabolic process to xylulose 5-phosphate
rRNA (adenine-N6-)-methyltransferase activity
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
N-acetyldiaminopimelate deacetylase activity
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
L-cystine L-cysteine-lyase (deaminating)
protein-glutamate methylesterase activity
N-acetylglucosamine-6-sulfatase activity
holo-[acyl-carrier-protein] synthase activity
SRP-dependent cotranslational protein targeting to membrane
acetyl-CoA biosynthetic process from pyruvate
intracellular membrane-bounded organelle
pyruvate dehydrogenase (acetyl-transferring) activity
phosphoribosylanthranilate isomerase activity
type II site-specific deoxyribonuclease activity
3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
purine nucleoside triphosphate catabolic process
ribonucleoside triphosphate phosphatase activity
anthranilate phosphoribosyltransferase activity
S-adenosylmethionine biosynthetic process
ATP-dependent DNA damage sensor activity
nucleoside transmembrane transporter activity
4-hydroxyphenylpyruvate dioxygenase activity
4-hydroxy-2-oxovalerate aldolase activity
tRNA (guanine(46)-N7)-methyltransferase activity
methylglyoxal reductase (NADPH-dependent) activity
arginine biosynthetic process via ornithine
UDP-N-acetylglucosamine 2-epimerase activity
L,L-diaminopimelate aminotransferase activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
glucose-1-phosphate thymidylyltransferase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
dolichyl-phosphate beta-D-mannosyltransferase activity
rRNA (adenine(2503)-C2-)-methyltransferase activity
tRNA (adenine(37)-C2)-methyltransferase activity
3-isopropylmalate dehydrogenase activity
racemase and epimerase activity, acting on carbohydrates and derivatives
carbohydrate derivative biosynthetic process
glutamine-fructose-6-phosphate transaminase (isomerizing) activity
purine-nucleoside phosphorylase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
inward rectifier potassium channel activity
regulation of monoatomic ion transmembrane transport
isocitrate dehydrogenase (NADP+) activity
galactose transmembrane transporter activity
glucose transmembrane transporter activity
prephenate dehydrogenase (NAD+) activity
prephenate dehydrogenase (NADP+) activity
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
rRNA (cytosine-N4-)-methyltransferase activity
protoheme IX farnesyltransferase activity
carboxyl- or carbamoyltransferase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
glutamate-1-semialdehyde 2,1-aminomutase activity
'de novo' NAD biosynthetic process from tryptophan
dTDP-4-dehydrorhamnose 3,5-epimerase activity
NAD-dependent protein deacetylase activity
protein-malonyllysine demalonylase activity
protein-succinyllysine desuccinylase activity
non-membrane spanning protein tyrosine phosphatase activity
quinoprotein glucose dehydrogenase activity
intracellular protein transmembrane transport
hydroxymethylglutaryl-CoA lyase activity
6,7-dimethyl-8-ribityllumazine synthase activity
protein-glutamate O-methyltransferase activity
thiamine diphosphate biosynthetic process
tetrahydrofolylpolyglutamate synthase activity
phosphoenolpyruvate carboxylase activity
nitrate transmembrane transporter activity
ubiquitin-like modifier activating enzyme activity
guanosine tetraphosphate metabolic process
inorganic phosphate transmembrane transporter activity
linear malto-oligosaccharide phosphorylase activity
glutamate-5-semialdehyde dehydrogenase activity
UDP-N-acetylgalactosamine biosynthetic process
UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
protein-glutamine N-methyltransferase activity
UTP:glucose-1-phosphate uridylyltransferase activity
carbon-nitrogen ligase activity, with glutamine as amido-N-donor
type VI protein secretion system complex
L-lysine catabolic process to acetyl-CoA via saccharopine
protein-disulfide reductase (NAD(P)) activity
tRNA (guanine(37)-N1)-methyltransferase activity
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
methylated-DNA-[protein]-cysteine S-methyltransferase activity
folic acid-containing compound biosynthetic process
2-deoxy-D-gluconate 3-dehydrogenase activity
phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity
pentaerythritol trinitrate reductase activity
methylcrotonoyl-CoA carboxylase activity
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity
4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
negative regulation of DNA recombination
proton motive force-driven plasma membrane ATP synthesis
N-acetylgalactosamine-6-sulfatase activity
enoyl-[acyl-carrier-protein] reductase (NADH) activity
metal ion transmembrane transporter activity
3-deoxy-7-phosphoheptulonate synthase activity
peptide transmembrane transporter activity
imidazoleglycerol-phosphate synthase activity
phosphoenolpyruvate carboxykinase (ATP) activity
ATP-dependent polynucleotide 5'-hydroxyl-kinase activity
deoxyribodipyrimidine photo-lyase activity
nucleobase-containing compound metabolic process
phosphatidylethanolamine biosynthetic process
phosphatidylserine decarboxylase activity
dTDP-4-dehydrorhamnose reductase activity
pteridine-containing compound metabolic process
serine-type D-Ala-D-Ala carboxypeptidase activity
tryptophan catabolic process to kynurenine
1,4-dihydroxy-2-naphthoyl-CoA synthase activity
molybdopterin molybdotransferase activity
diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
pyrimidine nucleotide biosynthetic process
inorganic anion transmembrane transporter activity
NAD+ synthase (glutamine-hydrolyzing) activity
ferrous iron transmembrane transporter activity
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
guanine phosphoribosyltransferase activity
hypoxanthine phosphoribosyltransferase activity
oxidoreductase activity, acting on the CH-NH group of donors
tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
obsolete nucleic acid phosphodiester bond hydrolysis
chromate transmembrane transporter activity
2,4-dienoyl-CoA reductase (NADPH) activity
N-acetylgalactosamine-6-phosphate deacetylase activity
N-acetylglucosamine-6-phosphate deacetylase activity
regulation of DNA-templated transcription elongation
transcription elongation-coupled chromatin remodeling
cyanophycin synthetase activity (L-aspartate-adding)
coproporphyrinogen dehydrogenase activity
porphyrin-containing compound biosynthetic process
indole-3-glycerol-phosphate synthase activity
4-alpha-hydroxytetrahydrobiopterin dehydratase activity
tetrahydrobiopterin biosynthetic process
rhamnose transmembrane transporter activity
3-deoxy-8-phosphooctulonate synthase activity
aryl-alcohol dehydrogenase (NADP+) activity
UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity
1-alkyl-2-acetylglycerophosphocholine esterase activity
DNA-3-methyladenine glycosylase activity
DNA-3-methylguanine glycosylase activity
DNA-7-methyladenine glycosylase activity
DNA-7-methylguanine glycosylase activity
phosphoribosyl-AMP cyclohydrolase activity
phosphoribosyl-ATP diphosphatase activity
4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity
dimethylallyl diphosphate biosynthetic process
ligase activity, forming carbon-nitrogen bonds
tRNA splicing, via endonucleolytic cleavage and ligation
Pteroylglutamic acid biosynthetic process
2-hydroxy-3-oxopropionate reductase activity
oxoglutarate dehydrogenase (succinyl-transferring) activity
galactoside 2-alpha-L-fucosyltransferase activity
protocatechuate 3,4-dioxygenase activity
D-ribulose-phosphate 3-epimerase activity
3-hydroxyacyl-CoA dehydrogenase activity
biotin-[acetyl-CoA-carboxylase] ligase activity
intramolecular phosphotransferase activity
mannosylglycoprotein endo-beta-mannosidase activity
nicotinamide riboside transmembrane transporter activity
cyclic pyranopterin monophosphate synthase activity
arginyl-tRNA--protein transferase activity
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
acetolactate synthase regulator activity
N-acetyl-gamma-glutamyl-phosphate reductase activity
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
4-carboxymuconolactone decarboxylase activity
phosphatidylcholine phospholipase C activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
carbohydrate transmembrane transporter activity
transcription-coupled nucleotide-excision repair, DNA damage recognition
orotidine-5'-phosphate decarboxylase activity
1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
glycerophospholipid biosynthetic process
phosphoglycerol geranylgeranyltransferase activity
UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
tyrosine-based site-specific recombinase activity
trans-2-enoyl-CoA reductase (NADPH) activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
L-aspartate:2-oxoglutarate aminotransferase activity
mannan endo-1,4-beta-mannosidase activity
acyl-phosphate glycerol-3-phosphate acyltransferase activity
obsolete sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
phosphoribosylformylglycinamidine cyclo-ligase activity
2-phosphosulfolactate phosphatase activity
protein secretion by the type VI secretion system
3'-tRNA processing endoribonuclease activity
3-deoxy-manno-octulosonate cytidylyltransferase activity
CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
3-phosphoshikimate 1-carboxyvinyltransferase activity
carbon-monoxide dehydrogenase (acceptor) activity
carbon-monoxide dehydrogenase (ferredoxin) activity
cellular modified amino acid biosynthetic process
hydrolase activity, hydrolyzing N-glycosyl compounds
obsolete ornithine(lysine) transaminase activity
phosphopantothenate--cysteine ligase activity
phosphopantothenoylcysteine decarboxylase activity
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
kynurenine-oxoglutarate transaminase activity
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity
exo-poly-alpha-galacturonosidase activity
D-alanine:2-oxoglutarate aminotransferase activity
lipopolysaccharide core region biosynthetic process
glycine biosynthetic process from serine
glycine hydroxymethyltransferase activity
Guanosine 5'-monophosphate biosynthetic process
N-acetylornithine carbamoyltransferase activity
[acyl-carrier-protein] phosphodiesterase activity