acyltransferase activity, transferring groups other than amino-acyl groups
4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity
glutamate synthase (ferredoxin) activity
hydrolase activity, acting on ester bonds
tyrosine-based site-specific recombinase activity
histidinol-phosphate transaminase activity
intracellular protein transmembrane transport
S-adenosylmethionine-dependent methyltransferase activity
DNA-binding transcription factor activity
Molybdenum cofactor biosynthetic process
Mo-molybdopterin cofactor biosynthetic process
glycerophosphodiester phosphodiesterase activity
pantetheine-phosphate adenylyltransferase activity
phosphate:acyl-[acyl carrier protein] acyltransferase activity
ATP-dependent DNA damage sensor activity
4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)
4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming)
regulation of DNA-templated transcription
Nicotinamide adenine dinucleotide phosphate
Nicotinic adenine dinucleotide phosphate
lysine biosynthetic process via diaminopimelate
L-methionine:thioredoxin-disulfide S-oxidoreductase activity
peptide-methionine (S)-S-oxide reductase activity
3-oxoacyl-[acyl-carrier-protein] synthase activity
RNA polymerase II transcription regulatory region sequence-specific DNA binding
purine-rich negative regulatory element binding
cell wall macromolecule biosynthetic process
negative regulation of ribosome biogenesis
UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
4-hydroxy-tetrahydrodipicolinate reductase
oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
guanosine tetraphosphate metabolic process
UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity
fructose 1,6-bisphosphate 1-phosphatase activity
glycine decarboxylation via glycine cleavage system
SRP-dependent cotranslational protein targeting to membrane
efflux transmembrane transporter activity
monoatomic cation transmembrane transporter activity
NAD+ synthase (glutamine-hydrolyzing) activity
adenylyl-sulfate reductase (thioredoxin) activity
phosphoadenylyl-sulfate reductase (thioredoxin) activity
sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
2-hydroxy-3-oxopropionate reductase activity
leukotriene C4 gamma-glutamyl transferase activity
metal ion transmembrane transporter activity
peptide transmembrane transporter activity
oxidoreductase activity, acting on metal ions
Proton-transporting ATP synthase complex catalytic core F(1)
proton-transporting ATP synthase activity, rotational mechanism
proton-transporting ATP synthase complex, catalytic core F(1)
protein serine/threonine kinase activity
protein transmembrane transporter activity
uroporphyrinogen III biosynthetic process
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity
phosphorelay response regulator activity
peptide-methionine (R)-S-oxide reductase activity
NADH dehydrogenase (ubiquinone) activity
trans-hexaprenyltranstransferase activity
N(6)-L-threonylcarbamoyladenine synthase activity
tRNA threonylcarbamoyladenosine modification
ubiquitin-like modifier activating enzyme activity
Pteroylglutamic acid biosynthetic process
acyl-L-homoserine-lactone lactonohydrolase activity
quinoprotein glucose dehydrogenase activity
anthranilate phosphoribosyltransferase activity
Guanosine 5'-monophosphate biosynthetic process
phosphopantothenate--cysteine ligase activity
phosphopantothenoylcysteine decarboxylase activity
thiamine diphosphate biosynthetic process
rRNA (cytosine-N4-)-methyltransferase activity
serine-type D-Ala-D-Ala carboxypeptidase activity
inorganic phosphate transmembrane transporter activity
UDP-4-amino-4-deoxy-L-arabinose aminotransferase
cellular aromatic compound metabolic process
DNA topoisomerase type I (single strand cut, ATP-independent) activity
imidazoleglycerol-phosphate dehydratase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
negative regulation of translational elongation
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
5-(carboxyamino)imidazole ribonucleotide mutase activity
L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
homoserine O-succinyltransferase activity
hydrolase activity, acting on glycosyl bonds
biotin-[acetyl-CoA-carboxylase] ligase activity
unsaturated rhamnogalacturonyl hydrolase activity
hydrolase activity, hydrolyzing O-glycosyl compounds
gluconate 2-dehydrogenase (acceptor) activity
'de novo' GDP-L-fucose biosynthetic process
enoyl-[acyl-carrier-protein] reductase (NADH) activity
trans-2-enoyl-CoA reductase (NAD+) activity
plasma membrane respiratory chain complex IV
arabinan endo-1,5-alpha-L-arabinosidase activity
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
extracellular polysaccharide biosynthetic process
glucose-1-phosphate thymidylyltransferase activity
UDP-N-acetylgalactosamine biosynthetic process
UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
lipopolysaccharide core region biosynthetic process
peptidyl-prolyl cis-trans isomerase activity
type II site-specific deoxyribonuclease activity
pyruvate dehydrogenase (quinone) activity
adenyl-nucleotide exchange factor activity
oxidoreductase activity, acting on the CH-CH group of donors
gluconate transmembrane transporter activity
Branched-chain amino acid biosynthetic process
L-leucine:2-oxoglutarate aminotransferase activity
5-formyltetrahydrofolate cyclo-ligase activity
Aromatic amino acid family biosynthetic process
3-phosphoshikimate 1-carboxyvinyltransferase activity
rhamnose transmembrane transporter activity
5-amino-6-(5-phosphoribosylamino)uracil reductase activity
ATP synthesis coupled electron transport
3-isopropylmalate dehydrogenase activity
glucose-fructose oxidoreductase activity
magnesium ion transmembrane transporter activity
diacetyl reductase ((S)-acetoin forming) activity
shikimate 3-dehydrogenase (NADP+) activity
[protein-PII] uridylyltransferase activity
racemase and epimerase activity, acting on amino acids and derivatives
mechanosensitive monoatomic ion channel activity
glycine biosynthetic process from serine
glycine hydroxymethyltransferase activity
ribonucleoside monophosphate biosynthetic process
ribose phosphate diphosphokinase activity
P-type potassium transmembrane transporter activity
S-adenosylhomocysteine deaminase activity
purine-nucleoside phosphorylase activity
oxoglutarate dehydrogenase (succinyl-transferring) activity
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity
initiator methionyl aminopeptidase activity
N-acetyl-gamma-glutamyl-phosphate reductase activity
obsolete ornithine(lysine) transaminase activity
holo-[acyl-carrier-protein] synthase activity
glucosylglycerol-phosphate synthase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
thiamine-phosphate diphosphorylase activity
phosphatidylcholine phospholipase C activity
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
4-hydroxybenzoate decarboxylase activity
glucose 1-dehydrogenase [NAD(P)] activity
arginine biosynthetic process via ornithine
O-phospho-L-serine:2-oxoglutarate aminotransferase activity
ATPase-coupled phosphate ion transmembrane transporter activity
negative regulation of DNA-templated transcription
acetolactate synthase regulator activity
acyl-[acyl-carrier-protein] desaturase activity
ligase activity, forming carbon-nitrogen bonds
formyltetrahydrofolate deformylase activity
ATP-binding cassette (ABC) transporter complex
double-strand break repair via nonhomologous end joining
adenine phosphoribosyltransferase activity
tRNA-guanosine(34) queuine transglycosylase activity
proton motive force-driven plasma membrane ATP synthesis
phosphoribosylformylglycinamidine synthase activity
histidine catabolic process to glutamate and formamide
histidine catabolic process to glutamate and formate
protein-disulfide reductase (NAD(P)) activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
acyl-[acyl-carrier-protein] hydrolase activity
oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
imidazoleglycerol-phosphate synthase activity
N-acetyl-beta-D-galactosaminidase activity
DNA-directed 5'-3' RNA polymerase activity
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
L-lysine catabolic process to acetyl-CoA via saccharopine
dihydrolipoyllysine-residue succinyltransferase activity
4-hydroxyphenylpyruvate dioxygenase activity
mannan endo-1,4-beta-mannosidase activity
peptidoglycan glycosyltransferase activity
acetyl-CoA biosynthetic process from pyruvate
intracellular membrane-bounded organelle
pyruvate dehydrogenase (acetyl-transferring) activity
ABC-type D-methionine transporter activity
exo-poly-alpha-galacturonosidase activity
thioredoxin-disulfide reductase (NADP) activity
methylated-DNA-[protein]-cysteine S-methyltransferase activity
galactose transmembrane transporter activity
glucose transmembrane transporter activity
beta-lactam antibiotic catabolic process
S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity
S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity
S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity
demethylmenaquinone methyltransferase activity
Adenosine 5'-triphosphate biosynthetic process
Adenosine triphosphate biosynthetic process
Proton-transporting ATP synthase complex coupling factor F(0)
proton-transporting ATP synthase complex, coupling factor F(o)
tetrahydrodipicolinate N-acetyltransferase activity
tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity
3-hydroxybenzoate 6-monooxygenase activity
nicotinamide riboside transmembrane transporter activity
double-stranded DNA 3'-5' DNA exonuclease activity
glucose-1-phosphate adenylyltransferase activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
negative regulation of DNA recombination
beta-maltose 4-alpha-glucanotransferase activity
4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity
dimethylallyl diphosphate biosynthetic process
NAD(P)H dehydrogenase (quinone) activity
N-acetylgalactosamine-6-phosphate deacetylase activity
N-acetylglucosamine-6-phosphate deacetylase activity
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
alpha-N-acetylgalactosaminidase activity
siderophore-iron transmembrane transporter activity
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
peptidoglycan beta-N-acetylmuramidase activity
L-aspartate:fumarate oxidoreductase activity
inorganic cation transmembrane transport
nicotinate phosphoribosyltransferase activity
1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
phosphotransferase activity, alcohol group as acceptor
beta-ketoacyl-acyl-carrier-protein synthase III activity
uroporphyrin-III C-methyltransferase activity
long-chain fatty acid-CoA ligase activity
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
prephenate dehydrogenase (NAD+) activity
prephenate dehydrogenase (NADP+) activity
deoxyribodipyrimidine photo-lyase activity
nucleobase-containing compound metabolic process
tRNA (guanine(37)-N1)-methyltransferase activity
phosphoribosyl-AMP cyclohydrolase activity
phosphoribosyl-ATP diphosphatase activity
electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
plasma membrane light-harvesting complex
inorganic anion transmembrane transporter activity
L-aspartate:2-oxoglutarate aminotransferase activity
oxidoreductase activity, acting on the CH-NH group of donors
tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
dolichyl-phosphate beta-D-mannosyltransferase activity
glutaminyl-peptide cyclotransferase activity
ATP-dependent diacylglycerol kinase activity
muramoyltetrapeptide carboxypeptidase activity
oxidative single-stranded DNA demethylation
sodium ion transmembrane transporter activity
purine-specific mismatch base pair DNA N-glycosylase activity
Deoxyribonucleotide biosynthetic process
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
glycine dehydrogenase (decarboxylating) activity
uracil phosphoribosyltransferase activity
1,4-alpha-glucan branching enzyme activity
1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)
enterobacterial common antigen biosynthetic process
phosphatidylethanolamine biosynthetic process
phosphatidylserine decarboxylase activity
glycerol-3-phosphate cytidylyltransferase activity
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
glycerol-3-phosphate dehydrogenase complex
phosphotransferase activity, for other substituted phosphate groups
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
dTDP-4-dehydrorhamnose reductase activity
L-arabinose catabolic process to xylulose 5-phosphate
carbon-nitrogen ligase activity, with glutamine as amido-N-donor
'de novo' pyrimidine nucleobase biosynthetic process
orotidine-5'-phosphate decarboxylase activity
protoporphyrinogen IX biosynthetic process
6,7-dimethyl-8-ribityllumazine synthase activity
nicotinate-nucleotide diphosphorylase (carboxylating) activity
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity
translation release factor activity, codon specific
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
'de novo' L-methionine biosynthetic process
aspartate-semialdehyde dehydrogenase activity
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
ammonium transmembrane transporter activity
6-aminohexanoate-dimer hydrolase activity
transcription-coupled nucleotide-excision repair, DNA damage recognition
pyrimidine nucleotide biosynthetic process
3-deoxy-7-phosphoheptulonate synthase activity
DNA replication, synthesis of RNA primer
ATPase-coupled monoatomic cation transmembrane transporter activity
phosphoribosylformylglycinamidine cyclo-ligase activity
tryptophan catabolic process to kynurenine
hydroxymethylglutaryl-CoA lyase activity
site-specific DNA-methyltransferase (adenine-specific) activity
regulation of DNA-templated transcription elongation
transcription elongation-coupled chromatin remodeling
carbohydrate derivative biosynthetic process
glutamine-fructose-6-phosphate transaminase (isomerizing) activity
pyrroline-5-carboxylate reductase activity
racemase and epimerase activity, acting on carbohydrates and derivatives
malate dehydrogenase (menaquinone) activity
phosphoribosylamine-glycine ligase activity
cyclic pyranopterin monophosphate synthase activity
isocitrate dehydrogenase (NADP+) activity
4-amino-4-deoxychorismate synthase activity
porphyrin-containing compound biosynthetic process
acyl-phosphate glycerol-3-phosphate acyltransferase activity
[acyl-carrier-protein] S-malonyltransferase activity
alkanal monooxygenase (FMN-linked) activity
asparagine synthase (glutamine-hydrolyzing) activity
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
4-hydroxy-tetrahydrodipicolinate synthase activity
4-amino-4-deoxychorismate lyase activity
3-hydroxyacyl-CoA dehydrogenase activity
protein-glutamate methylesterase activity
pyridoxine 5'-phosphate synthase activity
sulfate adenylyltransferase (ATP) activity
carboxyl- or carbamoyltransferase activity
1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity
methionyl-tRNA formyltransferase activity
chloramphenicol O-acetyltransferase activity
oxidoreductase activity, acting on NAD(P)H
glutamate-5-semialdehyde dehydrogenase activity
proton motive force-driven ATP synthesis
proton transmembrane transporter activity
(R)-limonene 1,2-monooxygenase NADH activity
(R)-limonene 1,2-monooxygenase NADPH activity
N-acetylmuramoyl-L-alanine amidase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
outer membrane-bounded periplasmic space
1-deoxy-D-xylulose-5-phosphate synthase activity
trans-aconitate 2-methyltransferase activity
UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
molybdopterin-synthase adenylyltransferase activity
1-deoxy-D-xylulose 5-phosphate biosynthetic process
protein-glutamate O-methyltransferase activity
malate dehydrogenase (decarboxylating) (NAD+) activity
malate dehydrogenase (decarboxylating) (NADP+) activity
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
phosphatidate cytidylyltransferase activity
3'-tRNA processing endoribonuclease activity
enzyme-directed rRNA pseudouridine synthesis
7,8-dihydroneopterin 3'-triphosphate biosynthetic process
Gram-negative-bacterium-type cell outer membrane assembly
3-deoxy-manno-octulosonate-8-phosphatase activity
DNA-3-methyladenine glycosylase activity
orotate phosphoribosyltransferase activity
methylenetetrahydrofolate reductase (NAD(P)H) activity
N-carbamoyl-D-amino acid hydrolase activity
glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity
type I site-specific deoxyribonuclease activity
dTDP-4-dehydrorhamnose 3,5-epimerase activity
xanthine phosphoribosyltransferase activity
cysteine biosynthetic process from serine
3-deoxy-manno-octulosonate cytidylyltransferase activity
CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
L-methionine-(R)-S-oxide reductase activity
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
cystathionine gamma-synthase activity (acts on O-phosphohomoserine)
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
monoatomic ion transmembrane transporter activity
organonitrogen compound biosynthetic process
phosphoenolpyruvate carboxykinase (ATP) activity
phosphatidylglycerol lysyltransferase activity
xenobiotic transmembrane transporter activity
UDP-N-acetylmuramate-L-alanine ligase activity
2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
gamma-aminobutyric acid catabolic process
succinate-semialdehyde dehydrogenase (NADP+) activity
ribonucleoside-diphosphate reductase complex
tetraacyldisaccharide 4'-kinase activity
phosphoribosylanthranilate isomerase activity
3-deoxy-8-phosphooctulonate synthase activity
carbohydrate derivative metabolic process
16S rRNA (guanine(966)-N(2))-methyltransferase activity
phosphoribosylglycinamide formyltransferase activity
galactoside 2-alpha-L-fucosyltransferase activity
glutamate-1-semialdehyde 2,1-aminomutase activity
succinyl-diaminopimelate desuccinylase activity
nucleoside transmembrane transporter activity
polysaccharide transmembrane transporter activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
phospho-N-acetylmuramoyl-pentapeptide-transferase activity
glycerol-3-phosphate biosynthetic process
crossover junction DNA endonuclease activity
leucyl-tRNA--protein transferase activity
23S rRNA (adenine(1618)-N(6))-methyltransferase activity
arabinogalactan endo-1,4-beta-galactosidase activity
obsolete sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
proton-transporting ATPase activity, rotational mechanism
ADP-glyceromanno-heptose 6-epimerase activity
rRNA (pseudouridine-N3-)-methyltransferase activity
protein quality control for misfolded or incompletely synthesized proteins
DNA unwinding involved in DNA replication
ADP-dependent NAD(P)H-hydrate dehydratase activity
nicotinamide nucleotide metabolic process
ATP-dependent chromatin remodeler activity
NAD-dependent protein deacetylase activity
protein-malonyllysine demalonylase activity
protein-succinyllysine desuccinylase activity
S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity
tRNA (adenine-N6)-methyltransferase activity
molybdenum cofactor guanylyltransferase activity
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
protein-(glutamine-N5) methyltransferase activity
propionate metabolic process, methylcitrate cycle
purine nucleoside triphosphate catabolic process
ribonucleoside triphosphate phosphatase activity
1-pyrroline-5-carboxylate dehydrogenase activity
polyribonucleotide nucleotidyltransferase activity
S-adenosylmethionine biosynthetic process
rRNA (guanine-N7-)-methyltransferase activity
DNA-binding transcription activator activity
3,4-dihydroxy-2-butanone-4-phosphate synthase activity
ferrous iron transmembrane transporter activity
phosphinothricin N-acetyltransferase activity
D-inositol-3-phosphate glycosyltransferase activity
glutamate dehydrogenase (NADP+) activity
phosphoribosylaminoimidazolecarboxamide formyltransferase activity
coproporphyrinogen dehydrogenase activity
arabinose-5-phosphate isomerase activity
sphingomyelin phosphodiesterase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
methylmalonyl-CoA carboxytransferase activity
L-threonine catabolic process to glycine
pentaerythritol trinitrate reductase activity
propionate catabolic process, 2-methylcitrate cycle
acetyl-CoA biosynthetic process from acetate
isopentenyl-diphosphate delta-isomerase activity
8-amino-7-oxononanoate synthase activity
glutamate dehydrogenase [NAD(P)+] activity
5-(carboxyamino)imidazole ribonucleotide synthase activity
phosphoribosylaminoimidazole carboxylase activity
UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
protoheme IX farnesyltransferase activity
guanine phosphoribosyltransferase activity
hypoxanthine phosphoribosyltransferase activity