initiator methionyl aminopeptidase activity
ATP synthesis coupled electron transport
5-phosphoribose 1-diphosphate biosynthetic process
ribonucleoside monophosphate biosynthetic process
ribose phosphate diphosphokinase activity
nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
monoatomic cation transmembrane transporter activity
crossover junction DNA endonuclease activity
DNA (cytosine-5-)-methyltransferase activity
ATP-dependent DNA damage sensor activity
bacterial-type flagellum-dependent swarming motility
intracellular protein transmembrane transport
protein transmembrane transporter activity
electron transport coupled proton transport
acyltransferase activity, transferring groups other than amino-acyl groups
DNA-binding transcription factor activity
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Pteroylglutamic acid biosynthetic process
DNA replication, Okazaki fragment processing
regulation of DNA-templated transcription
methionyl-tRNA formyltransferase activity
tetrahydrofolylpolyglutamate synthase activity
Nicotinamide adenine dinucleotide phosphate
Nicotinic adenine dinucleotide phosphate
phosphogluconate dehydrogenase (decarboxylating) activity
S-adenosylmethionine-dependent methyltransferase activity
protoporphyrinogen IX biosynthetic process
Two-component sensory transduction system
Two-component signal transduction system
hydrolase activity, acting on glycosyl bonds
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
4-hydroxy-tetrahydrodipicolinate synthase activity
lysine biosynthetic process via diaminopimelate
xenobiotic transmembrane transporter activity
L-methionine salvage from S-adenosylmethionine
L-methionine salvage from methylthioadenosine
adenyl-nucleotide exchange factor activity
DNA-directed 5'-3' RNA polymerase activity
1-deoxy-D-xylulose 5-phosphate biosynthetic process
1-deoxy-D-xylulose-5-phosphate synthase activity
Branched-chain amino acid biosynthetic process
peptidyl-prolyl cis-trans isomerase activity
translation release factor activity, codon specific
negative regulation of DNA-templated transcription
negative regulation of purine nucleobase metabolic process
serine-type D-Ala-D-Ala carboxypeptidase activity
purine-nucleoside phosphorylase activity
carboxyl- or carbamoyltransferase activity
oxidoreductase activity, acting on the CH-CH group of donors
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
peptide transmembrane transporter activity
N-acetyl-gamma-glutamyl-phosphate reductase activity
glutamate-1-semialdehyde 2,1-aminomutase activity
Phosphoenolpyruvate-dependent sugar phosphotransferase system
phosphoenolpyruvate-protein phosphotransferase activity
phosphatidylinositol phospholipase C activity
arginine biosynthetic process via ornithine
ATP-binding cassette (ABC) transporter complex
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NAD+ synthase (glutamine-hydrolyzing) activity
transmembrane signaling receptor activity
obsolete tRNA (adenine-N1)-methyltransferase activity
peptidoglycan glycosyltransferase activity
intracellular membrane-bounded organelle
leukotriene C4 gamma-glutamyl transferase activity
2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity
ribulose-bisphosphate carboxylase activity
ligase activity, forming carbon-nitrogen bonds
ABC-type amino acid transporter activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
organonitrogen compound metabolic process
branched-chain amino acid transmembrane transporter activity
N-acetylglucosamine-6-phosphate deacetylase activity
anthranilate phosphoribosyltransferase activity
phosphatidylglycerol lysyltransferase activity
porphyrin-containing compound biosynthetic process
ATPase-coupled monoatomic cation transmembrane transporter activity
cysteine biosynthetic process from serine
transferase activity, transferring alkyl or aryl (other than methyl) groups
intramolecular oxidoreductase activity, interconverting aldoses and ketoses
carbohydrate derivative metabolic process
P-type potassium transmembrane transporter activity
S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity
SRP-dependent cotranslational protein targeting to membrane
Molybdenum cofactor biosynthetic process
Mo-molybdopterin cofactor biosynthetic process
molybdopterin molybdotransferase activity
2-deoxy-D-gluconate 3-dehydrogenase activity
Adenosine 5'-triphosphate biosynthetic process
Adenosine triphosphate biosynthetic process
Proton-transporting ATP synthase complex coupling factor F(0)
proton-transporting ATP synthase activity, rotational mechanism
proton-transporting ATP synthase complex, coupling factor F(o)
lactate transmembrane transporter activity
tRNA (guanine(46)-N7)-methyltransferase activity
nicotinate phosphoribosyltransferase activity
4-hydroxy-tetrahydrodipicolinate reductase
oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
L-ribulose-phosphate 4-epimerase activity
UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
adenine phosphoribosyltransferase activity
UDP-N-acetylglucosamine 2-epimerase activity
ATPase-coupled transmembrane transporter activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
P450-containing electron transport chain
nucleobase-containing compound metabolic process
thiamine diphosphate biosynthetic process
bacterial-type flagellum basal body, rod
bacterial-type flagellum-dependent cell motility
dTDP-4-dehydrorhamnose reductase activity
sporulation resulting in formation of a cellular spore
protein serine/threonine kinase activity
pantetheine-phosphate adenylyltransferase activity
extracellular polysaccharide biosynthetic process
glucose-1-phosphate thymidylyltransferase activity
sulfate adenylyltransferase (ATP) activity
metal ion transmembrane transporter activity
phosphoribosylformylglycinamidine synthase activity
phosphotransferase activity, for other substituted phosphate groups
double-stranded DNA 3'-5' DNA exonuclease activity
Bacterial flagellar apparatus biogenesis
Bacterial flagellar apparatus protein export
S-methyl-5-thioadenosine phosphorylase activity
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Proton-transporting ATP synthase complex catalytic core F(1)
proton-transporting ATP synthase complex, catalytic core F(1)
pentaerythritol trinitrate reductase activity
Deoxyribonucleotide biosynthetic process
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
S-adenosylmethionine biosynthetic process
N-acylglucosamine-6-phosphate 2-epimerase activity
N-acylmannosamine-6-phosphate 2-epimerase activity
succinate-CoA ligase (ADP-forming) activity
succinate-CoA ligase (GDP-forming) activity
carbohydrate transmembrane transporter activity
histone H3K37 methyltransferase activity
threonine-phosphate decarboxylase activity
transcription-coupled nucleotide-excision repair, DNA damage recognition
Aromatic amino acid family biosynthetic process
bacterial-type flagellum basal body, MS ring
1,4-alpha-glucan branching enzyme activity
1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)
hydrolase activity, hydrolyzing O-glycosyl compounds
glucose-1-phosphate adenylyltransferase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
ATP-dependent chromatin remodeler activity
DNA-binding transcription activator activity
intramolecular phosphotransferase activity
rRNA (adenine(2503)-C2-)-methyltransferase activity
tRNA (adenine(37)-C2)-methyltransferase activity
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
'de novo' pyrimidine nucleobase biosynthetic process
formaldehyde assimilation via ribulose monophosphate cycle
orotidine-5'-phosphate decarboxylase activity
ammonium transmembrane transporter activity
L-aspartate:fumarate oxidoreductase activity
orotate phosphoribosyltransferase activity
5-amino-6-(5-phosphoribosylamino)uracil reductase activity
nitrate transmembrane transporter activity
UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
non-membrane spanning protein tyrosine kinase activity
UDP-N-acetylgalactosamine biosynthetic process
UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
dihydroorotate dehydrogenase (NADH) activity
dihydroorotate dehydrogenase (quinone) activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
phosphate-containing compound metabolic process
protein quality control for misfolded or incompletely synthesized proteins
enzyme-directed rRNA pseudouridine synthesis
N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity
pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
pyridoxal phosphate biosynthetic process
obsolete ornithine(lysine) transaminase activity
thioredoxin-disulfide reductase (NADP) activity
phosphoribosylformylglycinamidine cyclo-ligase activity
adenylyl-sulfate reductase (thioredoxin) activity
phosphoadenylyl-sulfate reductase (thioredoxin) activity
sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
N-acylphosphatidylethanolamine-specific phospholipase D activity
pyrroline-5-carboxylate reductase activity
acireductone dioxygenase (Ni2+-requiring) activity
acireductone dioxygenase [iron(II)-requiring] activity
arsenate reductase (thioredoxin) activity
response to arsenic-containing substance
negative regulation of DNA recombination
2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
positive regulation of sporulation resulting in formation of a cellular spore
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
glutamyl-tRNA(Gln) amidotransferase complex
cobalt ion transmembrane transporter activity
magnesium ion transmembrane transporter activity
protein serine/threonine phosphatase activity
adenosylmethionine decarboxylase activity
cytochrome bo3 ubiquinol oxidase activity
oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
tyrosine-based site-specific recombinase activity
NADH dehydrogenase (ubiquinone) activity
[protein-PII] uridylyltransferase activity
3-oxoacyl-[acyl-carrier-protein] synthase activity
UTP:glucose-1-phosphate uridylyltransferase activity
phosphotransferase activity, alcohol group as acceptor
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
carbon-nitrogen ligase activity, with glutamine as amido-N-donor
phosphoribosylamine-glycine ligase activity
L-arabinose catabolic process to xylulose 5-phosphate
(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
fructose 1,6-bisphosphate metabolic process
4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity
dimethylallyl diphosphate biosynthetic process
DNA replication, synthesis of RNA primer
DNA unwinding involved in DNA replication
UDP-glucose:hexose-1-phosphate uridylyltransferase activity
oxygen-dependent protoporphyrinogen oxidase activity
guanosine tetraphosphate biosynthetic process
5-(carboxyamino)imidazole ribonucleotide mutase activity
diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
1-acylglycerol-3-phosphate O-acyltransferase activity
negative regulation of translational initiation
regulation of bacterial-type flagellum assembly
regulation of carbohydrate metabolic process
glycerol-3-phosphate dehydrogenase complex
obsolete sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor
acyl-phosphate glycerol-3-phosphate acyltransferase activity
3-hydroxyacyl-CoA dehydrogenase activity
asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity
[acyl-carrier-protein] S-malonyltransferase activity
D-ribulose-phosphate 3-epimerase activity
ubiquitin-like modifier activating enzyme activity
thiamine-phosphate diphosphorylase activity
L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
homoserine O-succinyltransferase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidized purine nucleobase lesion DNA N-glycosylase activity
oxidoreductase activity, acting on metal ions
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Carbon utilization by fixation of carbon dioxide
phosphoenolpyruvate carboxylase activity
beta-ketoacyl-acyl-carrier-protein synthase III activity
inorganic phosphate transmembrane transporter activity
negative regulation of fatty acid biosynthetic process
mechanosensitive monoatomic ion channel activity
nucleoside transmembrane transporter activity
xenobiotic detoxification by transmembrane export across the plasma membrane
hydrolase activity, acting on ester bonds
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
phosphatidylglycerol biosynthetic process
rRNA (guanine-N7-)-methyltransferase activity
methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
phosphotransferase activity, phosphate group as acceptor
uracil phosphoribosyltransferase activity
glycine biosynthetic process from serine
glycine hydroxymethyltransferase activity
cobinamide phosphate guanylyltransferase activity
proton-transporting ATPase activity, rotational mechanism
phosphoribosyl-AMP cyclohydrolase activity
phosphoribosyl-ATP diphosphatase activity
ABC-type phosphonate transporter activity
peptidoglycan beta-N-acetylmuramidase activity
biotin transmembrane transporter activity
negative regulation of ribosome biogenesis
3-deoxy-7-phosphoheptulonate synthase activity
manganese ion transmembrane transporter activity
oxoglutarate dehydrogenase (succinyl-transferring) activity
histidinol-phosphate transaminase activity
nicotinate-nucleotide diphosphorylase (carboxylating) activity
5-(carboxyamino)imidazole ribonucleotide synthase activity
phosphoribosylaminoimidazole carboxylase activity
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Guanosine 5'-monophosphate biosynthetic process
formyltetrahydrofolate deformylase activity
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
glycerol-3-phosphate biosynthetic process
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
2-phosphosulfolactate phosphatase activity
1-pyrroline-5-carboxylate dehydrogenase activity
imidazoleglycerol-phosphate synthase activity
ABC-type vitamin B12 transporter activity
UDP-N-acetylglucosamine biosynthetic process
UDP-N-acetylglucosamine diphosphorylase activity
glucosamine-1-phosphate N-acetyltransferase activity
ABC-type D-methionine transporter activity
generation of precursor metabolites and energy
phosphoribosylglycinamide formyltransferase activity
LPPG:FO 2-phospho-L-lactate transferase activity
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
uroporphyrin-III C-methyltransferase activity
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
pteridine-containing compound metabolic process
ligand-gated monoatomic ion channel activity
cystathionine gamma-synthase activity (acts on O-phosphohomoserine)
xanthine phosphoribosyltransferase activity
3-phosphoshikimate 1-carboxyvinyltransferase activity
protein-glutamine gamma-glutamyltransferase activity
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
phosphorelay response regulator activity
protein-glutamate methylesterase activity
arsenite transmembrane transporter activity
N-acetylmuramoyl-L-alanine amidase activity
holo-[acyl-carrier-protein] synthase activity
CDP-diacylglycerol-serine O-phosphatidyltransferase activity
chromate transmembrane transporter activity
carbohydrate derivative biosynthetic process
glutamine-fructose-6-phosphate transaminase (isomerizing) activity
6-carboxy-5,6,7,8-tetrahydropterin synthase activity
inorganic diphosphate phosphatase activity
methylthioribulose 1-phosphate dehydratase activity
aminoglycoside 3-N-acetyltransferase activity
negative regulation of sporulation resulting in formation of a cellular spore
enoyl-[acyl-carrier-protein] reductase (NADH) activity
5'-methylthioadenosine deaminase activity
S-adenosylhomocysteine deaminase activity
phosphopantothenate--cysteine ligase activity
phosphopantothenoylcysteine decarboxylase activity
regulation of DNA-templated transcription elongation
malate dehydrogenase (menaquinone) activity
asparagine synthase (glutamine-hydrolyzing) activity
3,4-dihydroxy-2-butanone-4-phosphate synthase activity
protein tyrosine/serine/threonine phosphatase activity
dTDP-4-dehydrorhamnose 3,5-epimerase activity
molybdate ion transmembrane transporter activity
3-isopropylmalate dehydrogenase activity
guanine phosphoribosyltransferase activity
hypoxanthine phosphoribosyltransferase activity
acetolactate synthase regulator activity
1,4-alpha-oligoglucan phosphorylase activity
pyrimidine-nucleoside phosphorylase activity
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
L-leucine:2-oxoglutarate aminotransferase activity
S-methyl-5-thioribose-1-phosphate isomerase activity
imidazoleglycerol-phosphate dehydratase activity
acetyl-CoA:L-glutamate N-acetyltransferase activity
ABC-type carbohydrate transporter activity
inositol monophosphate 1-phosphatase activity
inositol monophosphate 3-phosphatase activity
inositol monophosphate 4-phosphatase activity
phosphatidylinositol phosphate biosynthetic process
N6-threonylcarbomyladenosine methylthiotransferase activity
7,8-dihydroneopterin 3'-triphosphate biosynthetic process
iron ion transmembrane transporter activity
rRNA (cytosine-N4-)-methyltransferase activity
biotin-[acetyl-CoA-carboxylase] ligase activity
methylenetetrahydrofolate reductase (NAD(P)H) activity
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
double-strand break repair via homologous recombination
NAD(P)H dehydrogenase (quinone) activity
purine-specific mismatch base pair DNA N-glycosylase activity
adenosylcobinamide-GDP ribazoletransferase activity
cobalamin 5'-phosphate synthase activity
rRNA (cytosine-2'-O-)-methyltransferase activity
pyruvate dehydrogenase (acetyl-transferring) activity
UDP-N-acetylmuramate dehydrogenase activity
obsolete 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity
tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent
prephenate dehydrogenase (NAD+) activity
prephenate dehydrogenase (NADP+) activity
N-acetylglucosamine transmembrane transporter activity
L-lysine catabolic process to acetyl-CoA via saccharopine
dihydrolipoyllysine-residue succinyltransferase activity
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
regulation of sporulation resulting in formation of a cellular spore
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity
DNA topoisomerase type I (single strand cut, ATP-independent) activity
tRNA-guanosine(34) queuine transglycosylase activity
transcription elongation-coupled chromatin remodeling
ABC-type putrescine transporter activity
nucleobase transmembrane transporter activity
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity
cyclic-di-AMP phosphodiesterase activity
UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
L-methionine:thioredoxin-disulfide S-oxidoreductase activity
peptide-methionine (R)-S-oxide reductase activity
peptide-methionine (S)-S-oxide reductase activity
double-strand break repair via nonhomologous end joining
glucosamine-6-phosphate deaminase activity
proteolysis involved in protein catabolic process
tRNA wobble adenosine to inosine editing
tRNA-specific adenosine-34 deaminase activity
deoxyribonuclease IV (phage-T4-induced) activity
triphosphoric monoester hydrolase activity
glutamate-5-semialdehyde dehydrogenase activity
phosphoribosylaminoimidazolecarboxamide formyltransferase activity
phosphate:acyl-[acyl carrier protein] acyltransferase activity
purine nucleobase transmembrane transport
protein serine/threonine/tyrosine kinase activity
3'-tRNA processing endoribonuclease activity
O-acetylhomoserine aminocarboxypropyltransferase activity
UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity
3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ethanolamine degradation polyhedral organelle
phosphoribosylglycinamide formyltransferase 2 activity
tRNA (guanine(37)-N1)-methyltransferase activity
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
proton motive force-driven plasma membrane ATP synthesis
isocitrate dehydrogenase (NADP+) activity
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity
isopentenyl-diphosphate delta-isomerase activity
UDP-N-acetylmuramate-L-alanine ligase activity
ATPase-coupled phosphate ion transmembrane transporter activity
nicotinate-nucleotide adenylyltransferase activity
6,7-dimethyl-8-ribityllumazine synthase activity
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
indole-3-glycerol-phosphate synthase activity
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
purine nucleoside triphosphate catabolic process
ribonucleoside triphosphate phosphatase activity
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
phospho-N-acetylmuramoyl-pentapeptide-transferase activity
oxidoreductase activity, acting on NAD(P)H
rRNA (pseudouridine-N3-)-methyltransferase activity
polyribonucleotide nucleotidyltransferase activity
phosphatidylethanolamine biosynthetic process
phosphatidylserine decarboxylase activity
O-phospho-L-serine:2-oxoglutarate aminotransferase activity
adenosylhomocysteine nucleosidase activity
methylthioadenosine nucleosidase activity
racemase and epimerase activity, acting on amino acids and derivatives
N(6)-L-threonylcarbamoyladenine synthase activity
tRNA threonylcarbamoyladenosine modification
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
glucose transmembrane transporter activity
malate dehydrogenase (decarboxylating) (NAD+) activity