Phosphoribosylformylglycinamidine synthase subunit PurL
Formylglycinamide ribonucleotide amidotransferase subunit II
Phosphoribosylformylglycinamidine synthase subunit II
Helicase HerA central domain-containing protein
NADPH-dependent 7-cyano-7-deazaguanine reductase
Cupin 2 conserved barrel domain-containing protein
D-malate dehydrogenase [decarboxylating]
ATP-dependent dethiobiotin synthetase BioD
Phosphatidylserine decarboxylase proenzyme
Ferric reductase like transmembrane component
Pyruvate dehydrogenase E1 component subunit alpha
Succinate dehydrogenase iron-sulfur subunit
DNA-directed RNA polymerase subunit omega
Right handed beta helix domain-containing protein
Putative membrane protein insertion efficiency factor
Amidohydrolase-related domain-containing protein
Phosphoribosylformylglycinamidine synthase subunit PurQ
Formylglycinamide ribonucleotide amidotransferase subunit I
Phosphoribosylformylglycinamidine synthase subunit I
serine-type D-Ala-D-Ala carboxypeptidase
Core-binding (CB) domain-containing protein
Apea-like HEPN domain-containing protein
RNA signal recognition particle 4.5S RNA
Peptidase M15A C-terminal domain-containing protein
BioF2-like acetyltransferase domain-containing protein
Glucose-1-phosphate thymidylyltransferase
Glycosyltransferase RgtA/B/C/D-like domain-containing protein
Cyclic pyranopterin monophosphate synthase
Molybdenum cofactor biosynthesis protein C
NADPH-dependent FMN reductase-like domain-containing protein
Calcineurin-like phosphoesterase domain-containing protein
Pyridoxine/pyridoxamine 5'-phosphate oxidase
S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase
Bacterial dipeptidyl-peptidase SH3 domain-containing protein
Uracil-DNA glycosylase-like domain-containing protein
5-bromo-4-chloroindolyl phosphate hydrolysis protein
Diaminobutyrate--2-oxoglutarate transaminase
Blue (type 1) copper domain-containing protein
Fimbrial biogenesis outer membrane usher protein
Histidine kinase/HSP90-like ATPase domain-containing protein
Sec-independent protein translocase protein TatC
Bacterial surface antigen (D15) domain-containing protein
Alpha/beta hydrolase fold-3 domain-containing protein
Phosphoribosylformylglycinamidine cyclo-ligase
Phosphoribosyl-aminoimidazole synthetase
Nucleotidyl transferase AbiEii toxin, Type IV TA system
Phosphoribosylformylglycinamidine synthase subunit PurS
Formylglycinamide ribonucleotide amidotransferase subunit III
Phosphoribosylformylglycinamidine synthase subunit III
Large ribosomal subunit assembly factor BipA
Glycosyl transferase family 1 domain-containing protein
Helix-turn-helix domain-containing protein
Tyr recombinase domain-containing protein
NIF system FeS cluster assembly NifU N-terminal domain-containing protein
Phosphoribosylglycinamide formyltransferase
5'-phosphoribosylglycinamide transformylase
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
Colanic acid biosynthesis glycosyltransferase WcaL
ATP-dependent Clp protease adapter protein ClpS
Succinate--CoA ligase [ADP-forming] subunit alpha
Two component regulator three Y domain-containing protein
NAD-dependent epimerase/dehydratase domain-containing protein
Putative zinc-finger domain-containing protein
Succinate dehydrogenase flavoprotein subunit
Activator of Hsp90 ATPase 1 family protein
Cytochrome b561 bacterial/Ni-hydrogenase domain-containing protein
Nicotinamide nucleotide transhydrogenase subunit beta
Resolvase/invertase-type recombinase catalytic domain-containing protein
Bifunctional NAD(P)H-hydrate repair enzyme
Bacterial HORMA domain-containing protein
Terminase large subunit gp17-like C-terminal domain-containing protein
Dihydroneopterin aldolase/epimerase domain-containing protein
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Conjugal transfer pilus assembly protein TraV
Polyribonucleotide nucleotidyltransferase
K(+)-insensitive pyrophosphate-energized proton pump
Membrane-bound proton-translocating pyrophosphatase
Pyrophosphate-energized inorganic pyrophosphatase
Putative Flp pilus-assembly TadG-like N-terminal domain-containing protein
Nucleotidyl transferase domain-containing protein
Peptide methionine sulfoxide reductase MsrA
Peptide-methionine (S)-S-oxide reductase
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
7,8-diamino-pelargonic acid aminotransferase
Crossover junction endodeoxyribonuclease RuvC
Conjugal transfer pilus assembly protein TraK
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO
Folate-dependent tRNA (uracil-5-)-methyltransferase
Folate-dependent tRNA(M-5-U54)-methyltransferase
Glycerophosphoryl diester phosphodiesterase membrane domain-containing protein
Ribbon-helix-helix protein CopG domain-containing protein
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Luciferase-like domain-containing protein
Amidohydrolase 3 domain-containing protein
ATP-dependent Clp protease proteolytic subunit
Flagella basal body P-ring formation protein FlgA C-terminal domain-containing protein
Bifunctional adenosylcobalamin biosynthesis protein
Phosphate transport system permease protein
Cytochrome oxidase maturation protein, cbb3-type
4-hydroxy-tetrahydrodipicolinate synthase
Dimethylallyl diphosphate:tRNA dimethylallyltransferase
Isopentenyl-diphosphate:tRNA isopentenyltransferase
Aminoglycoside phosphotransferase domain-containing protein
Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein
Sulfatase N-terminal domain-containing protein
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
Succinate--CoA ligase [ADP-forming] subunit beta
CHK kinase-like domain-containing protein
Release factor glutamine methyltransferase
Protein-glutamine N-methyltransferase PrmC
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
Flagellar hook-basal body complex protein FliE
Periplasmic sensor diguanylate cyclase/phosphodiesterase
Probable queuosine precursor transporter
TonB-dependent receptor-like beta-barrel domain-containing protein
Ribbon-helix-helix domain-containing protein
Chromosomal replication initiator protein DnaA
Non-discriminating aspartyl-tRNA synthetase
T6SS immunity protein Tdi1 C-terminal domain-containing protein
HTH cro/C1-type domain-containing protein
Type IV secretion system coupling protein TraD DNA-binding domain-containing protein
Phosphodiester glycosidase domain-containing protein
N-terminal of MaoC-like dehydratase domain-containing protein
3-keto-5-aminohexanoate cleavage protein
N-acetylmuramidase domain-containing protein
4-hydroxy-tetrahydrodipicolinate reductase
RNA polymerase-binding transcription factor DksA
Ribosomal RNA small subunit methyltransferase G
16S rRNA 7-methylguanosine methyltransferase
N-acetyl-gamma-glutamyl-phosphate reductase
N-acetyl-glutamate semialdehyde dehydrogenase
Holliday junction branch migration complex subunit RuvB
Pantetheine-phosphate adenylyltransferase
Glutamyl-gamma-semialdehyde dehydrogenase
Peptide methionine sulfoxide reductase MsrB
Peptide-methionine (R)-S-oxide reductase
Dihydrofolate synthase/folylpolyglutamate synthase
Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase
Enoyl-[acyl-carrier-protein] reductase [NADH]
FAD/NAD(P)-binding domain-containing protein
Bacteriophage tail tape measure C-terminal domain-containing protein
proton-translocating NAD(P)(+) transhydrogenase
Acetyltransferase component of pyruvate dehydrogenase complex
DNA methylase adenine-specific domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III
3-oxoacyl-[acyl-carrier-protein] synthase 3
3-oxoacyl-[acyl-carrier-protein] synthase III
MalT-like TPR region domain-containing protein
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
2-oxoglutarate dehydrogenase complex component E2
Sec-independent protein translocase protein TatA
Copper resistance protein D domain-containing protein
Transposase IS200-like domain-containing protein
Ribosomal RNA large subunit methyltransferase E
GapR-like DNA-binding domain-containing protein
N-acetyltransferase domain-containing protein
Cell wall hydrolase SleB domain-containing protein
Molybdopterin synthase catalytic subunit
Molybdenum cofactor biosynthesis protein E
Molybdopterin-converting factor large subunit
Molybdopterin-converting factor subunit 2
3-methyl-2-oxobutanoate hydroxymethyltransferase
Lipopolysaccharide assembly protein A domain-containing protein
ADP/GDP-polyphosphate phosphotransferase
Phosphate regulon transcriptional regulatory protein PhoB
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein
Acyl-phosphate--glycerol-3-phosphate acyltransferase
Metallo-beta-lactamase domain-containing protein
ATP-dependent Clp protease ATP-binding subunit ClpX
4Fe-4S Mo/W bis-MGD-type domain-containing protein
uroporphyrinogen-III C-methyltransferase
Phosphatidylglycerol lysyltransferase C-terminal domain-containing protein
Cytokinin riboside 5'-monophosphate phosphoribohydrolase
IrrE N-terminal-like domain-containing protein
Major facilitator superfamily (MFS) profile domain-containing protein
N5-carboxyaminoimidazole ribonucleotide synthase
5-(carboxyamino)imidazole ribonucleotide synthetase
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Extradiol ring-cleavage dioxygenase LigAB LigA subunit domain-containing protein
KfrA N-terminal DNA-binding domain-containing protein
Thioredoxin-dependent 5'-adenylylsulfate reductase
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Ribosomal RNA small subunit methyltransferase H
rRNA (cytosine-N(4)-)-methyltransferase RsmH
biotin--[biotin carboxyl-carrier protein] ligase
SGNH hydrolase-type esterase domain-containing protein
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
Holin of 3TMs, for gene-transfer release
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Beta-lactamase hydrolase-like protein phosphatase-like domain-containing protein
NADH:ubiquinone reductase (H(+)-translocating)
RiboL-PSP-HEPN domain-containing protein
Non-canonical purine NTP pyrophosphatase
MobA/MobL protein domain-containing protein
Limonene-1,2-epoxide hydrolase domain-containing protein
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Electron transfer flavoprotein alpha/beta-subunit N-terminal domain-containing protein
Ribosomal protein uS12 methylthiotransferase RimO
Ribosomal protein uS12 (aspartate-C(3))-methylthiotransferase
Phenylalanyl-tRNA synthetase beta subunit
Bifunctional purine biosynthesis protein PurH
Endonuclease/exonuclease/phosphatase domain-containing protein
UDP-N-acetylmuramoylalanine--D-glutamate ligase
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Enoyl reductase (ER) domain-containing protein
2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase
Histidine phosphotransferase ChpT C-terminal domain-containing protein
3-isopropylmalate dehydratase small subunit
Outer membrane protein beta-barrel domain-containing protein
Carbamoyl-phosphate synthase small chain
Carbamoyl-phosphate synthetase glutamine chain
Stress-response A/B barrel domain-containing protein
Branched-chain-amino-acid aminotransferase
Spore coat protein U domain-containing protein
Succinate dehydrogenase hydrophobic membrane anchor subunit
tRNA N6-adenosine threonylcarbamoyltransferase
t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
2-oxoisovalerate dehydrogenase subunit alpha
Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain
Fumarylacetoacetase-like C-terminal domain-containing protein
Signal transduction histidine kinase internal region domain-containing protein
Alginate export domain-containing protein
S-adenosylmethionine:tRNA ribosyltransferase-isomerase
Cob(II)yrinic acid a,c-diamide adenosyltransferase
Cobinamide/cobalamin adenosyltransferase
Type I restriction enzyme R protein N-terminal domain-containing protein
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
TIGR02281 family clan AA aspartic protease
UDP-MurNAc-pentapeptide phosphotransferase
Methyltransferase type 11 domain-containing protein
Transcription termination/antitermination protein NusG
Phosphate transport system permease protein PstA
CDP-diacylglycerol--serine O-phosphatidyltransferase
Lipopolysaccharide export system permease protein LptF
NAD(P)-binding domain-containing protein
Regulatory protein FmdB Zinc ribbon domain-containing protein
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Peptidase S24/S26A/S26B/S26C domain-containing protein
Acetyl-coenzyme A carboxylase biotin carboxylase subunit A
GntR C-terminal domain-containing protein
Phosphate-specific transport system accessory protein PhoU
Ribosomal RNA small subunit methyltransferase E
Tip attachment protein J domain-containing protein
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Signal recognition particle receptor FtsY
Energy-dependent translational throttle protein EttA
Sec-independent protein translocase protein TatB
Protein-glutamate methylesterase/protein-glutamine glutaminase
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
UDP-N-acetylglucosamine enolpyruvyl transferase
5-phospho-D-ribosyl alpha-1-diphosphate synthase
Putative auto-transporter adhesin head GIN domain-containing protein
1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase
N5-carboxyaminoimidazole ribonucleotide mutase
5-(carboxyamino)imidazole ribonucleotide mutase
Thymidine diphospho-4-keto-rhamnose 3,5-epimerase
Flagellar assembly protein FliH/Type III secretion system HrpE domain-containing protein
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
ABC transporter domain-containing protein
Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase
Dienelactone hydrolase domain-containing protein
Electron transfer flavoprotein-ubiquinone oxidoreductase
YubB ferredoxin-like domain-containing protein
Acyl-[acyl-carrier-protein]--phosphate acyltransferase
phosphoenolpyruvate--protein phosphotransferase
Ribonucleoside-diphosphate reductase subunit beta
Transcription antitermination protein NusB
2-dehydro-3-deoxy-phosphogluconate aldolase
Putative pyruvate, phosphate dikinase regulatory protein
Outer membrane protein assembly factor BamD
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 7
Acetaldehyde dehydrogenase [acetylating]
Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Bifunctional uridylyltransferase/uridylyl-removing enzyme
Bifunctional [protein-PII] modification enzyme
Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein
DNA-directed RNA polymerase subunit beta
Probable potassium transport system protein Kup
LexA repressor DNA-binding domain-containing protein
CobQ/CobB/MinD/ParA nucleotide binding domain-containing protein
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Imidazole glycerol phosphate synthase subunit HisF
UDP-N-acetylmuramoyl-L-alanine synthetase
tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ
tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase
Pyruvate dehydrogenase E1 component subunit beta
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)
Autotransporter domain-containing protein
Nudix hydrolase domain-containing protein
MotA/TolQ/ExbB proton channel domain-containing protein
DNA-directed RNA polymerase subunit beta'
NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein
Antitoxin Xre/MbcA/ParS-like toxin-binding domain-containing protein
PepSY-associated TM helix domain-containing protein
Nucleotide modification associated domain-containing protein
2-hydroxychromene-2-carboxylate isomerase
NfeD-like C-terminal domain-containing protein
Leucyl/phenylalanyl-tRNA--protein transferase
MIP18 family-like domain-containing protein
Holliday junction branch migration complex subunit RuvA
Cytochrome c-type biogenesis protein CcmE
Guanylate cyclase domain-containing protein
3-isopropylmalate dehydratase large subunit
Phosphohydroxythreonine aminotransferase
Serine aminopeptidase S33 domain-containing protein
3-oxoacyl-[acyl-carrier-protein] synthase 2
Dolichyl-phosphate-mannose--protein mannosyltransferase
AB hydrolase-1 domain-containing protein
3-oxoacyl-[acyl-carrier-protein] reductase
Circularly permuted ATPgrasp domain-containing protein
Putative phage metallopeptidase domain-containing protein
Basal-body rod modification protein FlgD
Hydroxymethylpyrimidine phosphate synthase
Aldehyde dehydrogenase domain-containing protein
Activator of Hsp90 ATPase homologue 1-like C-terminal domain-containing protein
glycine dehydrogenase (aminomethyl-transferring)
Large-conductance mechanosensitive channel
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C
Glyceraldehyde-3-phosphate dehydrogenase
Phospho-2-dehydro-3-deoxyheptonate aldolase
Imidazole glycerol phosphate synthase subunit HisH
Oxidoreductase probably involved in sulfite reduction
Cytochrome bo(3) ubiquinol oxidase subunit 3
Cytochrome o ubiquinol oxidase subunit 3
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
GlsB/YeaQ/YmgE family stress response membrane protein
4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase
Ubiquinol-cytochrome c reductase iron-sulfur subunit
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Histidine-specific methyltransferase SAM-dependent domain-containing protein
DNA-(apurinic or apyrimidinic site) lyase
Aspartate-beta-semialdehyde dehydrogenase
Nucleoside 5'-monophosphate phosphohydrolase
Conjugal transfer pilus assembly protein TraA
Abortive infection protein-like C-terminal domain-containing protein
Molybdenum cofactor biosynthesis protein A
Probable transcriptional regulatory protein NSU_1993
TauD/TfdA-like domain-containing protein
Probable nicotinate-nucleotide adenylyltransferase
Nicotinate mononucleotide adenylyltransferase
CMP/dCMP-type deaminase domain-containing protein
Osmoregulatory trehalose synthesis protein A
UDP-glucose-glucosephosphate glucosyltransferase
(S)-ureidoglycine aminohydrolase cupin domain-containing protein
Transcription termination/antitermination protein NusA
Lycopene cyclase domain-containing protein
Small-conductance mechanosensitive channel
Probable glycine dehydrogenase (decarboxylating) subunit 1
Glycine cleavage system P-protein subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Secondary thiamine-phosphate synthase enzyme
PEP-CTERM protein-sorting domain-containing protein
Type IV conjugative transfer system protein TraL
HpcH/HpaI aldolase/citrate lyase domain-containing protein
Pili assembly chaperone N-terminal domain-containing protein
DNA-directed RNA polymerase subunit alpha
Carbamoyl-phosphate synthase large chain
Carbamoyl-phosphate synthetase ammonia chain
Lysozyme inhibitor LprI N-terminal domain-containing protein
Glutamyl-tRNA(Gln) amidotransferase subunit A
Two-component system, LytT family, response regulator
Molybdenum cofactor biosynthesis protein B
N-acetyl-L-glutamate 5-phosphotransferase
CD-NTase-associated protein 12/Pycsar effector protein TIR domain-containing protein
Probable chemoreceptor glutamine deamidase CheD
Cytochrome c oxidase assembly protein CtaG
Mycothiol-dependent maleylpyruvate isomerase metal-binding domain-containing protein
5-enolpyruvylshikimate-3-phosphate phospholyase
UTP--glucose-1-phosphate uridylyltransferase
Alpha-D-glucosyl-1-phosphate uridylyltransferase
Uridine diphosphoglucose pyrophosphorylase
Peptidase S8/S53 domain-containing protein
4-hydroxythreonine-4-phosphate dehydrogenase
4-(phosphohydroxy)-L-threonine dehydrogenase
Heavy-metal-associated domain-containing protein
Probable branched-chain-amino-acid aminotransferase
Phospholipase D-like domain-containing protein
Probable multidrug resistance protein NorM
Ferritin/DPS protein domain-containing protein
Phenylalanine--tRNA ligase alpha subunit
Phenylalanyl-tRNA synthetase alpha subunit
Elp3/MiaA/NifB-like radical SAM core domain-containing protein
Glutamine phosphoribosylpyrophosphate amidotransferase
ABC3 transporter permease protein domain-containing protein
S-(hydroxymethyl)glutathione dehydrogenase
Bacterial mobilisation domain-containing protein
MobA-like NTP transferase domain-containing protein
Alpha-keto-beta-hydroxylacyl reductoisomerase
Lipocalin-like domain-containing protein
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Endolytic peptidoglycan transglycosylase RlpA
Transporter (Formate/nitrite transporter family protein)
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
L-glutamine--D-fructose-6-phosphate amidotransferase
site-specific DNA-methyltransferase (adenine-specific)
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase
UDP-N-acetylmuramyl-tripeptide synthetase
Urate oxidase N-terminal domain-containing protein
LPS export ABC transporter periplasmic protein LptC
Sulphur transport domain-containing protein
Malonyl CoA-acyl carrier protein transacylase
Phosphoribosylaminoimidazole-succinocarboxamide synthase
Replication-associated recombination protein A
Molybdopterin synthase sulfur carrier subunit
4-hydroxy-2-keto-pentanoic acid aldolase
Transglycosylase SLT domain-containing protein