99287:STM0109
gene id: 99287:STM0109
uniprot id: Q8ZRV0
names: Function
messages: Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain.

99287:STM3863
gene id: 99287:STM3863
uniprot id: Q8ZKW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

99287:STM3968
gene id: 99287:STM3968
uniprot id: P0A1F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate.
messages: Cytoplasm
messages: Homohexamer.

99287:STM1976
gene id: 99287:STM1976
uniprot id: P26418
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).

99287:STM0400
gene id: 99287:STM0400
uniprot id: P37460
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Cell inner membrane
messages: Permease that is involved in the transport across the cytoplasmic membrane of proline.

99287:STM3284
gene id: 99287:STM3284
uniprot id: Q8ZLT2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

99287:STM1286
gene id: 99287:STM1286
uniprot id: Q7CQP6
names: Similarity
messages: Belongs to the MipA/OmpV family.

99287:STM0073
gene id: 99287:STM0073
uniprot id: Q8ZRX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA.
messages: Cytoplasm
messages: Homotetramer.

99287:STM3727
gene id: 99287:STM3727
uniprot id: P0A7P2
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL33 family.
messages: Part of the 50S ribosomal subunit. Cross-links to the P and E site tRNAs (By similarity).
messages: Surface exposed on the 50S subunit.

99287:STM1388
gene id: 99287:STM1388
uniprot id: P0A1T4
names: Function
names: Similarity
messages: Belongs to the FumD family.
messages: In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate.

99287:STM4532
gene id: 99287:STM4532
uniprot id: Q8ZJY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

99287:STM1583
gene id: 99287:STM1583
uniprot id: Q8ZPD7
names: Function
names: Subcellular Location Annotation
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.
messages: Host cytoplasm
messages: Secreted

99287:STM0360
gene id: 99287:STM0360
uniprot id: Q8ZRG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

99287:STM2083
gene id: 99287:STM2083
uniprot id: P26405
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cell membrane
messages: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group B O antigen.

99287:STM0141
gene id: 99287:STM0141
uniprot id: Q8ZRT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

99287:STM3518
gene id: 99287:STM3518
uniprot id: Q8ZLI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

99287:STM2466
gene id: 99287:STM2466
uniprot id: P41790
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: Can use ethanolamine (EA) as a nitrogen source but not as a carbon source (PubMed:2656649, PubMed:23585538). Not required for aerobic growth on EA supplemented with cobalamin (vitamin B12); deletions and mutations in this gene probably have polar effects on downstream gene expression. A double eutD-eutM and a quadruple eutP-eutQ-eutT-eutD deletion are not required for growth in the above conditions (PubMed:10464203). Somewhat reduced growth on EA, no excretion of acetate from cells. Reduced growth is due to residual nutrients from rich medium (PubMed:16272400, PubMed:23585538). A non-polar deletion mutant does not grow on EA between pH 5.5 and pH 8.5, releases slightly increased amounts of acetaldehyde on EA plus vitamin B12 (PubMed:16585748).
messages: Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Homodimer.
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).
messages: Required for the use of ethanolamide (EA) as carbon, but not nitrogen, source (Probable). Involved in acetate metabolism during growth on EA, when expressed independently of the eut operon it can restore growth to a double pta-acs deletion mutant (PubMed:14996820). Required for acetate excretion during growth on EA (PubMed:16272400).

99287:STM1506
gene id: 99287:STM1506
uniprot id: Q8ZPJ0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

99287:STM3865
gene id: 99287:STM3865
uniprot id: Q7CPE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

99287:STM0578
gene id: 99287:STM0578
uniprot id: P15888
names: Function
names: Similarity
names: Subunit
messages: Belongs to the nitroreductase family.
messages: Homodimer.
messages: Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity).

99287:STM0075
gene id: 99287:STM0075
uniprot id: Q8ZRX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of FixA and FixB.
messages: Required for anaerobic carnitine reduction. May bring reductant to CaiA.

99287:STM4464
gene id: 99287:STM4464
uniprot id: Q8ZK36
names: Subcellular Location Annotation
messages: Membrane

99287:STM2350
gene id: 99287:STM2350
uniprot id: Q8ZNC8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

99287:STM3615
gene id: 99287:STM3615
uniprot id: Q8ZLB9
names: Similarity
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.

99287:STM4172
gene id: 99287:STM4172
uniprot id: Q9L9I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZraP family.
messages: Binds zinc. Could be an important component of the zinc-balancing mechanism (By similarity).
messages: Periplasm

99287:STM4065
gene id: 99287:STM4065
uniprot id: Q8ZKR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

99287:STM0703
gene id: 99287:STM0703
uniprot id: Q8ZQW4
names: Subcellular Location Annotation
messages: Membrane

99287:STM4240
gene id: 99287:STM4240
uniprot id: Q7CPB2
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

99287:STM0343
gene id: 99287:STM0343
uniprot id: Q8ZRH6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.
messages: Membrane

99287:STM1986
gene id: 99287:STM1986
uniprot id: P65417
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. MPGP family.
messages: Cytoplasm

99287:STM0204
gene id: 99287:STM0204
uniprot id: Q7CR66
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

99287:STM1517
gene id: 99287:STM1517
uniprot id: Q56072
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Cell inner membrane
messages: May be an export pump for several amino acids and their metabolites, including cysteine.

99287:STM4045
gene id: 99287:STM4045
uniprot id: Q8ZKS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. RhaD subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
messages: Cytoplasm
messages: Homotetramer.

99287:STM0441
gene id: 99287:STM0441
uniprot id: Q8ZRC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

99287:STM1653
gene id: 99287:STM1653
uniprot id: Q7CQH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

99287:STM4062
gene id: 99287:STM4062
uniprot id: P65692
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

99287:STM4105
gene id: 99287:STM4105
uniprot id: P11003
names: Function
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.
messages: Catalyzes the NADH-dependent reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. Is required to provide the methyl group necessary for methionine synthetase to convert homocysteine to methionine; the methyl group is given by 5-methyltetrahydrofolate.

99287:STM3929
gene id: 99287:STM3929
uniprot id: P37457
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family.
messages: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.

99287:STM1180
gene id: 99287:STM1180
uniprot id: P0A1N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

99287:STM2284
gene id: 99287:STM2284
uniprot id: Q8ZNG5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

99287:STM3112
gene id: 99287:STM3112
uniprot id: Q8ZM39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase Slt family.
messages: Cell outer membrane
messages: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.

99287:STM0146
gene id: 99287:STM0146
uniprot id: P0CL03
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Cytoplasm
messages: Involved in cell wall peptidoglycan recycling. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety.
messages: Zn(2+) is required for amidase activity.

99287:STM4466
gene id: 99287:STM4466
uniprot id: Q8ZK34
names: Similarity
messages: Belongs to the carbamate kinase family.

99287:STM3269
gene id: 99287:STM3269
uniprot id: Q7CPQ5
names: Similarity
messages: Belongs to the peptidase C56 family.

99287:STM1062
gene id: 99287:STM1062
uniprot id: Q8ZQ72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

99287:STM0999
gene id: 99287:STM0999
uniprot id: P37432
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2 (By similarity).
messages: Homotrimer.

99287:STM0458
gene id: 99287:STM0458
uniprot id: Q8ZRB5
names: Function
names: Similarity
messages: A cysteine desulfhydrase that generates hydrogen sulfide, H(2)S. The H(2)S produced by this enzyme may modulate central metabolism.
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family. Cds1 subfamily.

99287:STM4047
gene id: 99287:STM4047
uniprot id: P27030
names: Function
names: Similarity
messages: Belongs to the rhamnulokinase family.
messages: Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate.

99287:STM1565
gene id: 99287:STM1565
uniprot id: Q7CQJ0
names: Function
names: Similarity
names: Subunit
messages: Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein.
messages: Associates exclusively with the 30S subunit; there is 0.1 copy per ribosome in the exponential phase and 0.4 copies per ribosome in the stationary phase.
messages: Belongs to the SRA family.

99287:STM2032
gene id: 99287:STM2032
uniprot id: Q05628
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

99287:PSLT055
gene id: 99287:PSLT055
uniprot id: P23831
names: Function
names: Similarity
messages: Belongs to the peptidase S24 family.
messages: Involved in UV protection and mutation.

99287:STM4233
gene id: 99287:STM4233
uniprot id: Q8ZKI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiC family.
messages: Cytoplasm
messages: Monomer.
messages: Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.

99287:STM3225
gene id: 99287:STM3225
uniprot id: Q8ZLX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell inner membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).

99287:STM2691
gene id: 99287:STM2691
uniprot id: Q8ZMV8
names: Subcellular Location Annotation
messages: Membrane

99287:STM0812
gene id: 99287:STM0812
uniprot id: Q8ZQP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily.
messages: Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane

99287:STM4525
gene id: 99287:STM4525
uniprot id: P40813
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the N(4)/N(6)-methyltransferase family.
messages: The subtype gamma methyltransferase (M) subunit of a type I restriction enzyme. The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues of the sequence 5'-GAGN(6)GTRC-3'. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S; the restriction enzyme has stoichiometry R(2)M(2)S(1) while the methyltransferase is M(2)S(1).
messages: Type I restriction and modification enzymes are complex, multifunctional systems which require ATP, S-adenosyl methionine and Mg(2+) as cofactors and, in addition to their endonucleolytic and methylase activities, are potent DNA-dependent ATPases.

99287:STM3812
gene id: 99287:STM3812
uniprot id: Q8ZL00
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

99287:STM0615
gene id: 99287:STM0615
uniprot id: Q8ZR17
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

99287:STM2030
gene id: 99287:STM2030
uniprot id: Q05632
names: Caution
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Bacterial-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
messages: Was originally thought to be a precorrin-8w decarboxylase.

99287:STM0985
gene id: 99287:STM0985
uniprot id: Q8ZQC2
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

99287:STM2109
gene id: 99287:STM2109
uniprot id: H9L499
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM0151
gene id: 99287:STM0151
uniprot id: P0CL10
names: Function
messages: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd.

99287:STM1626
gene id: 99287:STM1626
uniprot id: Q8ZPA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane
messages: Membrane

99287:STM3816
gene id: 99287:STM3816
uniprot id: Q7CQ65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

99287:STM3185
gene id: 99287:STM3185
uniprot id: Q7CPS2
names: Function
names: Similarity
names: Subunit
messages: Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.
messages: Belongs to the Nudix hydrolase family. NudF subfamily.
messages: Homodimer.

99287:STM0454
gene id: 99287:STM0454
uniprot id: Q7CR23
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

99287:STM1773
gene id: 99287:STM1773
uniprot id: P0A2L9
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the UPF0162 family.
messages: Not essential for the ability to invade cultured HeLa cells (the invasive phenotype).
messages: Required for maximal expression of sirC, not required to invade host cells.

99287:STM3599
gene id: 99287:STM3599
uniprot id: Q8ZLD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

99287:STM3448
gene id: 99287:STM3448
uniprot id: P0A7S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex (By similarity).
messages: With S4 and S5 plays an important role in translational accuracy.

99287:STM3660
gene id: 99287:STM3660
uniprot id: Q8ZL91
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

99287:STM3338
gene id: 99287:STM3338
uniprot id: P0A2G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
messages: Catalyzes the proton-dependent transport of sialic acid.
messages: Cell inner membrane

99287:STM1233
gene id: 99287:STM1233
uniprot id: Q8ZPZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell inner membrane
messages: Cytoplasm

99287:STM1332
gene id: 99287:STM1332
uniprot id: P0A235
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS.

99287:STM0941
gene id: 99287:STM0941
uniprot id: Q8ZQE5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

99287:STM2222
gene id: 99287:STM2222
uniprot id: P65840
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine synthase RsuA family.
messages: Monomer.
messages: Responsible for synthesis of pseudouridine from uracil-516 in 16S ribosomal RNA.

99287:STM1139
gene id: 99287:STM1139
uniprot id: P0A204
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgG family.
messages: Cell membrane
messages: May be involved in the biogenesis of curli organelles.

99287:STM2328
gene id: 99287:STM2328
uniprot id: Q7CQ49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

99287:STM4147
gene id: 99287:STM4147
uniprot id: P0A2D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

99287:STM2482
gene id: 99287:STM2482
uniprot id: Q8ZN76
names: Similarity
messages: Belongs to the ArsC family.

99287:STM2146
gene id: 99287:STM2146
uniprot id: P55882
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiD family.
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
messages: Homodimer.

99287:PSLT046
gene id: 99287:PSLT046
uniprot id: Q7DAP2
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

99287:STM3881
gene id: 99287:STM3881
uniprot id: Q8ZKW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

99287:STM0131
gene id: 99287:STM0131
uniprot id: Q7CR81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

99287:STM0199
gene id: 99287:STM0199
uniprot id: H9L4A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM2031
gene id: 99287:STM2031
uniprot id: P0A2H1
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8.

99287:STM2298
gene id: 99287:STM2298
uniprot id: O52324
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Plays an important role in pathogenesis by providing resistance to antimicrobial peptides within macrophages or at other anatomic sites encountered during infection.
messages: Cell inner membrane
messages: Induced by BasR.

99287:STM2982
gene id: 99287:STM2982
uniprot id: Q7CPV9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM1628
gene id: 99287:STM1628
uniprot id: Q8ZPA7
names: Similarity
messages: Belongs to the FrmR/RcnR family.

99287:STM3027
gene id: 99287:STM3027
uniprot id: Q8ZM91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

99287:STM1820
gene id: 99287:STM1820
uniprot id: Q7CQE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.
messages: Cytoplasm
messages: Has been identified as the first Gram-negative bacterial RPF (Resuscitation-Promoting Factor) capable of reviving VNC (viable but non-culturable) cells when added externally, but the million-fold lower activity as compared to Gram-positive bacterial RPFs may indicate a lack of physiological relevance.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE; this reaction does not require ATP in vitro. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity). Neither binds polyphosphates nor a wide range of nucleotides on its own. Does not show O-sialoglycoprotein endopeptidase activity.

99287:STM0039
gene id: 99287:STM0039
uniprot id: Q8ZRZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

99287:STM3923
gene id: 99287:STM3923
uniprot id: Q9L6R2
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

99287:STM4343
gene id: 99287:STM4343
uniprot id: Q7CP97
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).

99287:STM3340
gene id: 99287:STM3340
uniprot id: P67735
names: Function
names: Similarity
messages: Belongs to the NanR family.
messages: Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids.

99287:STM4439
gene id: 99287:STM4439
uniprot id: P63727
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b562 family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule.
messages: Electron-transport protein of unknown function.
messages: Periplasm

99287:STM4005
gene id: 99287:STM4005
uniprot id: P41789
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
messages: Phosphorylated and dephosphorylated by NtrB.

99287:STM3515
gene id: 99287:STM3515
uniprot id: Q8ZLI3
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by ATP and maltotriose, which are both required for DNA binding.
messages: Belongs to the MalT family.
messages: Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.
messages: Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.

99287:STM3377
gene id: 99287:STM3377
uniprot id: P67347
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

99287:STM2025
gene id: 99287:STM2025
uniprot id: Q05592
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiK family.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
messages: Homotrimer.

99287:STM0137
gene id: 99287:STM0137
uniprot id: Q8ZRT6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

99287:STM4236
gene id: 99287:STM4236
uniprot id: Q7CPB3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

99287:STM1957
gene id: 99287:STM1957
uniprot id: P59696
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the IS200/IS605 insertion sequence (IS) element family.
messages: Belongs to the transposase 17 family.
messages: Homodimer.
messages: Transposase responsible for transposition of the IS200 insertion sequence (IS) element. Transposition occurs in 2 main steps, excision from the donor DNA 'top strand' into a single strand circle and its subsequent reinsertion into the DNA target. This increases the copy number of the IS.

99287:STM0025
gene id: 99287:STM0025
uniprot id: H9L408
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM3303
gene id: 99287:STM3303
uniprot id: P66131
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

99287:STM2815
gene id: 99287:STM2815
uniprot id: Q8ZMK8
names: Subcellular Location Annotation
messages: Membrane

99287:STM2199
gene id: 99287:STM2199
uniprot id: Q8ZNL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

99287:STM1337
gene id: 99287:STM1337
uniprot id: P67038
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

99287:STM4538
gene id: 99287:STM4538
uniprot id: Q8ZJX9
names: Subcellular Location Annotation
messages: Membrane

99287:STM1445
gene id: 99287:STM1445
uniprot id: P0A1X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Pcp/SlyB lipoprotein family.
messages: Cell outer membrane

99287:STM0987
gene id: 99287:STM0987
uniprot id: Q7CQT7
names: Similarity
messages: Belongs to the UPF0434 family.

99287:STM0336
gene id: 99287:STM0336
uniprot id: Q8ZRI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

99287:STM0768
gene id: 99287:STM0768
uniprot id: Q8ZQS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcdB/MmdB/OadB family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.
messages: Membrane

99287:STM1422
gene id: 99287:STM1422
uniprot id: P96069
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Part of a type III secretion system.

99287:STM1230
gene id: 99287:STM1230
uniprot id: P0DM80
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: 10,000-fold reduction in virulence in male BALB/c mice (for strain ATCC 14028). Decreased tolerance to acid stress.
messages: Autokinase and kinase activities depend on low (uM range) Mg(2+) concentrations. Phosphatase activity is stimulated by high (mM range) Mg(2+) concentrations and ADP at 1 mM. Autokinase inhibited by radicicol.
messages: Binds up to 3 divalent cations (Ca(2+) or Mg(2+)); increasing concentrations of divalent cations allows better binding to phospholipids.
messages: Cell inner membrane
messages: Homodimer (Probable); probably dimerizes via the cytoplasmic domain. Interacts with MgrB in the periplasm, altering its activity and that of downstream effector PhoP (By similarity).
messages: Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Essential for transcription of spiC inside macrophages by controlling the expression of the two-component regulatory system SsrB/SpiR (SsrA) and Pir at transcriptional and post-transcriptional levels respectively. Promotes expression of the two-component regulatory system PmrA/PmrB via activation of pmrD gene. Is required to attenuate bacterial growth within fibroblast cells and to enhance bacterial resistance to bile in intestinal cells. Negatively regulates prgH, which is required for invasion of epithelial cells. Involved in acid tolerance.
messages: Substitutions experiments show that amino acid Thr-48 may be involved in the conformational changes responsible for the balance between kinase-dominant state and phosphatase-dominant state.
messages: The PhoP/PhoQ-signaling cascade, which activates virulence membrane genes (pagC, pagO, pagD, pagK, pgtE and phoN), is induced by cationic antimicrobial peptides (CAMP) (polymyxin, alpha-helical peptide C18G and sheet peptide protegrin-1) at sublethal concentrations.
messages: The phoP/phoQ operon is positively autoregulated by both PhoP and PhoQ in a Mg(2+)-dependent manner. Repressed by RcsB via sigma factor RpoS.

99287:STM0391
gene id: 99287:STM0391
uniprot id: Q8ZRE7
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

99287:STM2065
gene id: 99287:STM2065
uniprot id: P37600
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Component of the PhsABC thiosulfate reductase that catalyzes the reduction of thiosulfate to sulfite and hydrogen sulfide, with menaquinol as the sole electron donor. Proton motive force (PMF) is required to drive transmembrane electron transfer within the reductase. The PhsA subunit contains the active site molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor.
messages: Composed of three subunits: PhsA, PhsB and PhsC.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

99287:STM2388
gene id: 99287:STM2388
uniprot id: Q8ZNA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

99287:STM1088
gene id: 99287:STM1088
uniprot id: Q8ZQ59
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Does not appear to be required for the formation or the maintenance of either Salmonella-containing vacuole (SCV) or the Salmonella-induced filaments (Sifs). Not required for intracellular replication in phagocytic cells.
messages: Expression is regulated by the two-component regulatory system SsrA/SsrB. Induced after bacterial entry into host cell.
messages: Host membrane
messages: Secreted

99287:STM4129
gene id: 99287:STM4129
uniprot id: P22038
names: Function
names: Induction
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs.
messages: Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
messages: Growth rate-dependent regulation of transcription. Is a novel example of a mRNA regulated through a mechanism similar to that of a stable RNA (rRNA).

99287:STM2389
gene id: 99287:STM2389
uniprot id: Q8ZNA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).

99287:STM2335
gene id: 99287:STM2335
uniprot id: P60817
names: Similarity
messages: Belongs to the UPF0304 family.

99287:STM1058
gene id: 99287:STM1058
uniprot id: P25468
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

99287:STM2366
gene id: 99287:STM2366
uniprot id: Q7CQ41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

99287:STM1746
gene id: 99287:STM1746
uniprot id: P06202
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm
messages: This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity.

99287:STM1343
gene id: 99287:STM1343
uniprot id: Q8ZPS7
names: Similarity
messages: Belongs to the peptidase C40 family.

99287:STM4163
gene id: 99287:STM4163
uniprot id: Q9L9I8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

99287:STM3565
gene id: 99287:STM3565
uniprot id: Q7CPJ9
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PanZ/PanM family.
messages: Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion (By similarity). Binding of CoA or a derivative to PanM leads to interaction with PanD, which promotes the processing and activation of pro-PanD, and subsequent substrate-mediated inhibition of the active form of PanD (By similarity) (PubMed:22497218, PubMed:22782525). Lacks acetyltransferase activity (PubMed:22782525).
messages: Deletion results in a pantothenate auxotrophy. Deletion mutant accumulates pro-PanD.
messages: Interacts with PanD in the presence of CoA (PubMed:22497218, PubMed:22782525). Monomer (PubMed:22497218).
messages: Lacks the conserved catalytic glutamate found in many enzymatically active members of the Gcn5-like N-acetyltransferase (GNAT) family.

99287:STM3057
gene id: 99287:STM3057
uniprot id: Q8ZM73
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

99287:STM0196
gene id: 99287:STM0196
uniprot id: H9L4A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

99287:STM3178
gene id: 99287:STM3178
uniprot id: Q8ZLZ9
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation (By similarity).

99287:STM2433
gene id: 99287:STM2433
uniprot id: P0A283
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per glycerol kinase EIIA-Glc dimer. The zinc ion is important for dimerization.
messages: Cytoplasm
messages: Heterodimer with glycerol kinase (glpk).
messages: In mutants defective in enzyme I and histidine-containing phosphate carrier protein (HPr), cells lacking this gene are able to grow on the non-PTS compounds such as glycerol, maltose, melibiose, mannose 6-phosphate, and alpha-glycerol phosphate.
messages: The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport (PubMed:6754734, PubMed:6292227). It can also phosphorylate mannose, methyl alpha-glucoside and 2-deoxy-glucose (PubMed:6292227). The non-phosphorylated EIII-Glc is an inhibitor for uptake of certain sugars such as maltose, melibiose, lactose, and glycerol. Phosphorylated EIII-Glc, however, may be an activator for adenylate cyclase (PubMed:789369).
messages: Two forms of III-Glc (called IIIGlc Slow and IIIGlc Fast) are present in living cells. IIIGlc Fast, derived from IIIGlc Slow by cleavage of the seven NH2-terminal amino acids, is present only in trace quantities and has slight activity (only 2-3% of phospho-IIIGlc Slow) in the phosphorylation of sugar. Both forms accept phosphate from phosphoenolpyruvate via Enzyme I and HPr, however only IIIGlc Slow participates in the phosphorylation of glucose or methyl alpha-D-glucoside. IIIGlc Fast may play a role in the regulation of non-PTS sugar transport systems.

99287:STM1185
gene id: 99287:STM1185
uniprot id: Q8ZQ17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Belongs to the RNase E/G family. RNase G subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

99287:STM4053
gene id: 99287:STM4053
uniprot id: Q8ZKR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

99287:STM4101
gene id: 99287:STM4101
uniprot id: Q8ZKN4
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

99287:STM2692
gene id: 99287:STM2692
uniprot id: Q8ZMV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

99287:STM1964
gene id: 99287:STM1964
uniprot id: Q06399
names: Subcellular Location Annotation
messages: Cell membrane

99287:STM3203
gene id: 99287:STM3203
uniprot id: Q7CPR8
names: Subcellular Location Annotation
messages: Membrane

99287:STM0650
gene id: 99287:STM0650
uniprot id: Q8ZQZ5
names: Similarity
messages: Belongs to the UxaA family.

99287:STM2355
gene id: 99287:STM2355
uniprot id: P02911
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Has a bi-lobal structure (PubMed:1748660, PubMed:8496186, PubMed:7929349). Contains two globular domains separated by a deep cleft wherein the ligand-binding site is located (PubMed:1748660, PubMed:8496186).
messages: Part of the ABC transporter complex HisPMQ-ArgT involved in lysine/arginine/ornithine transport (PubMed:24021237). Binds lysine, arginine and ornithine (PubMed:6273842, PubMed:1400387, PubMed:8496186, PubMed:7929349). Can also bind histidine, with much lower affinity (PubMed:1400387, PubMed:7929349). Stimulates ATPase activity of HisP (PubMed:24021237).
messages: Periplasm
messages: The 30-fold reduced affinity of the protein for histidine is primarily due to unavailability of one ionic interaction of the histidine side chain with the protein which is present in the other three complexes.
messages: The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (ArgT).

99287:STM1136
gene id: 99287:STM1136
uniprot id: Q7CQR9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the PHP family.
messages: Binds 3 Zn(2+) ions per subunit.
messages: Homotrimer.

99287:STM3441
gene id: 99287:STM3441
uniprot id: P67904
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

99287:STM1587
gene id: 99287:STM1587
uniprot id: Q8ZPD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

99287:STM1168
gene id: 99287:STM1168
uniprot id: Q7CQR2
names: Similarity
messages: Belongs to the UPF0502 family.

99287:STM2930
gene id: 99287:STM2930
uniprot id: Q8ZMF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Homodimer.

99287:STM2114
gene id: 99287:STM2114
uniprot id: H9L4C3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

99287:STM1799
gene id: 99287:STM1799
uniprot id: Q7CQE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase Slt family.
messages: Cell outer membrane
messages: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.

99287:STM1885
gene id: 99287:STM1885
uniprot id: Q8ZNW3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

99287:STM2662
gene id: 99287:STM2662
uniprot id: P65836
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine synthase RluA family.
messages: Binds Obg/YhbZ (AC Q8ZLS5).
messages: Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA.

99287:STM1761
gene id: 99287:STM1761
uniprot id: Q8ZP40
names: Subcellular Location Annotation
messages: Membrane

99287:STM1392
gene id: 99287:STM1392
uniprot id: Q8ZPP5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM3320
gene id: 99287:STM3320
uniprot id: P26979
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein GlnG(NtrC).

99287:STM1220
gene id: 99287:STM1220
uniprot id: Q8ZPZ9
names: Function
names: Induction
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family. NagK subfamily.
messages: Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.
messages: Expressed in mid-log phase, part of the nagK-cobB operon (PubMed:20889757).

99287:STM2647
gene id: 99287:STM2647
uniprot id: P67073
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Monomer.

99287:STM1453
gene id: 99287:STM1453
uniprot id: Q8ZPM5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

99287:STM1149
gene id: 99287:STM1149
uniprot id: Q8ZQ27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyltransferase 3 family. OpgC subfamily.
messages: Cell membrane
messages: Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.

99287:STM3048
gene id: 99287:STM3048
uniprot id: Q8ZM80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-modifying YgfZ family.
messages: Cytoplasm
messages: Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.

99287:STM1336
gene id: 99287:STM1336
uniprot id: P0A7L6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).

99287:STM0757
gene id: 99287:STM0757
uniprot id: P24520
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Cell inner membrane
messages: Repressed by NadR.
messages: Required for nicotinamide riboside transport across the inner membrane.

99287:STM3096
gene id: 99287:STM3096
uniprot id: Q8ZM51
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

99287:STM4583
gene id: 99287:STM4583
uniprot id: P37444
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TrpR family.
messages: Cytoplasm
messages: Homodimer.
messages: This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity).

99287:STM0169
gene id: 99287:STM0169
uniprot id: Q8ZRS1
names: Similarity
messages: Belongs to the bacterial PQQ dehydrogenase family.

99287:STM0207
gene id: 99287:STM0207
uniprot id: P60217
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
messages: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
messages: Homodimer.

99287:STM4121
gene id: 99287:STM4121
uniprot id: Q8ZKL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

99287:STM2158
gene id: 99287:STM2158
uniprot id: Q8ZNN2
names: Function
names: PTM
messages: Member of the two-component regulatory system BtsS/BtsR. BtsR regulates expression of btsT by binding to its promoter region.
messages: Phosphorylated by BtsS.

99287:STM1002
gene id: 99287:STM1002
uniprot id: P40817
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the diaminopropionate ammonia-lyase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: By DL-DAP (at protein level).
messages: Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate (DAP) to form pyruvate and ammonia. In vitro L- and D-isomers of serine are also degraded, though slowly; it is the only serine dehydratase which can eliminate an amino group at the beta-carbon position. In vivo L-, D- and a mixure of DL-DAP allow growth. DL-DAP is toxic in the absence of this enzyme, it may inhibit enzymes involved in the synthesis of pyruvate and aspartate, as well as amino acids derived from them.
messages: Competitively inhibited by L- and D-alanine.
messages: Homodimer.
messages: No growth on minimal medium plus DL-DAP; growth can be restored by a mix of 8 amino acids (Arg, Asn, Cys, Glu, Ile, Leu, Met and Thr).

99287:STM3547
gene id: 99287:STM3547
uniprot id: Q8ZLG0
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

99287:STM3434
gene id: 99287:STM3434
uniprot id: P0A7V6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity).
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. Some nascent polypeptide chains are able to cross-link to this protein in situ (By similarity).

99287:STM1098
gene id: 99287:STM1098
uniprot id: Q8ZQ51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily.
messages: Catalyzes the reduction of free flavins (FMN, FAD and riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the large HpaB component or to other electron acceptors such as cytochrome c and Fe(3+) ion (By similarity).
messages: Homodimer. 4-HPA 3-monooxygenase consists of a reductase component HpaC and an oxygenase component HpaB (By similarity).

99287:STM1490
gene id: 99287:STM1490
uniprot id: Q8ZPK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily.
messages: Cell inner membrane
messages: Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.

99287:STM3973
gene id: 99287:STM3973
uniprot id: P0A2H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

99287:STM2168
gene id: 99287:STM2168
uniprot id: Q8ZNM6
names: Similarity
messages: Belongs to the peptidase S11 family.

99287:STM2271
gene id: 99287:STM2271
uniprot id: P58662
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Activation probably requires a transfer of a phosphate group from a His in the transmitter domain to an Asp in the receiver domain.
messages: Belongs to the RcsC family.
messages: Cell inner membrane
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane-associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB.
messages: Interacts with RcsD.

99287:STM3915
gene id: 99287:STM3915
uniprot id: P0AA28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thioredoxin family.
messages: Monomer.
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

99287:STM2917
gene id: 99287:STM2917
uniprot id: Q8ZMG5
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of 3-oxo-tetronate to 3-oxo-tetronate 4-phosphate.
messages: Deletion mutant is unable to use L-threonate or D-erythronate as a carbon source.

99287:STM1997
gene id: 99287:STM1997
uniprot id: P22494
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.
messages: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template.

99287:STM0429
gene id: 99287:STM0429
uniprot id: P96062
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Induced when inorganic phosphate is limiting; this is controlled by PhoB.
messages: Maps to a phosphate-starvation-inducible locus previously known as psiC.
messages: Periplasm
messages: Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import.

99287:STM0470
gene id: 99287:STM0470
uniprot id: P66296
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

99287:STM3578
gene id: 99287:STM3578
uniprot id: P67100
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfur carrier protein TusA family.
messages: Cytoplasm
messages: Interacts with IscS.
messages: Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.

99287:STM3103
gene id: 99287:STM3103
uniprot id: Q8ZM45
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

99287:STM4437
gene id: 99287:STM4437
uniprot id: P60829
names: Similarity
messages: Belongs to the UPF0307 family.

99287:STM3946
gene id: 99287:STM3946
uniprot id: P0A1T6
names: Subcellular Location Annotation
messages: Cell membrane

99287:STM0240
gene id: 99287:STM0240
uniprot id: Q8ZRN3
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

99287:STM0857
gene id: 99287:STM0857
uniprot id: Q8ZQL7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

99287:STM3708
gene id: 99287:STM3708
uniprot id: Q8ZL52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

99287:STM0945
gene id: 99287:STM0945
uniprot id: Q8ZQE3
names: Similarity
messages: Belongs to the ClpA/ClpB family.

99287:STM1196
gene id: 99287:STM1196
uniprot id: P0A6B1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

99287:STM3439
gene id: 99287:STM3439
uniprot id: P60726
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
messages: Part of the 50S ribosomal subunit.
messages: Protein L4 is a both a transcriptional repressor and a translational repressor protein. It regulates transcription of the S10 operon (to which L4 belongs) by causing premature termination of transcription within the S10 leader. L4 controls the translation of the S10 operon by binding to its mRNA.

99287:STM0969
gene id: 99287:STM0969
uniprot id: Q8ZQD1
names: Subcellular Location Annotation
messages: Membrane

99287:STM3884
gene id: 99287:STM3884
uniprot id: P0A2C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose.
messages: Periplasm
messages: The complex is composed of an ATP-binding protein (RbsA), two transmembrane proteins (RbsC) and a solute-binding protein (RbsB).

99287:STM0315
gene id: 99287:STM0315
uniprot id: Q7CR53
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

99287:STM2886
gene id: 99287:STM2886
uniprot id: P69066
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LcrH/SycD chaperone family.
messages: Cytoplasm
messages: Dimer or higher-order oligomers.
messages: Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE.

99287:STM4009
gene id: 99287:STM4009
uniprot id: H9L427
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA (By similarity). A ribosome-stimulated GTPase, GTPase activity increases 4 fold in the presence of 70S ribosomes. Binds 70S ribosomes in the presence of GTP or its non-hydrolyzable analog GMPPNP; in the presence of ppGpp or under stress conditions it binds to 30S ribosomal subunits (PubMed:18621905, PubMed:19803466).
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Has 5 domains; domain I (residues 1-202, also called the G domain), II (203-305, also called the beta barrel domain), III (306-386) V (387-479) and the C-terminal domain (CTD 480-607) which is BipA-specific. Domains I-V are homologous to domains in EF-G and LepA; although the domains are similar, their relative arrangement among these proteins is different. Domains I and II are not required for ribosome binding, although in their absence no 30S binding under stress is seen, whereas domains III, V and the CTD are required to bind both 70S and 30S ribosomes. The data suggests interdomain communication modulates GTPase and ribosome binding.
messages: Induced 7-fold when cells are treated with human bactericidal permeability-increasing protein (BPI, AC P17213) (at protein level).
messages: Monomer.
messages: Ribosome-associated GTPase is not affected by low levels of ppGpp, >40 uM ppGpp and >50 uM GDP inhibit GTPase (PubMed:18621905). The C-terminus (residues 387-607 or 481-607) inhibits GTPase activity, in its absence kcat increases, but GTPase is no longer stimulated by 70S ribosome or 30S or 50S subunits (PubMed:19803466).

99287:STM2855
gene id: 99287:STM2855
uniprot id: Q8ZMI7
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

99287:STM3129
gene id: 99287:STM3129
uniprot id: Q8ZM28
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

99287:STM3983
gene id: 99287:STM3983
uniprot id: Q9L6L5
names: Function
names: Similarity
names: Subunit
messages: Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).
messages: In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
messages: Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.

99287:STM0077
gene id: 99287:STM0077
uniprot id: Q8ZRW9
names: Function
names: Similarity
messages: Belongs to the ETF-QO/FixC family.
messages: Could be part of an electron transfer system required for anaerobic carnitine reduction.

99287:STM0666
gene id: 99287:STM0666
uniprot id: O87576
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane

99287:STM3598
gene id: 99287:STM3598
uniprot id: Q8ZLD3
names: Similarity
messages: Belongs to the asparaginase 1 family.

99287:STM2688
gene id: 99287:STM2688
uniprot id: P0A2G1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Not essential, it has a diminished capacity to survive in murine macrophages.
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

99287:STM3957
gene id: 99287:STM3957
uniprot id: P0A231
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase A1 family.
messages: Binds 1 Ca(2+) ion per monomer. In the dimeric form the Ca(2+) is bound by different amino acids with binding of each Ca(2+) shared with ligands coming from each monomer. The Ca(2+) ion may have a role in catalysis.
messages: Cell outer membrane
messages: Homodimer; dimerization is reversible, and the dimeric form is the active one.
messages: Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.

99287:STM2519
gene id: 99287:STM2519
uniprot id: Q9XCI8
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

99287:STM2027
gene id: 99287:STM2027
uniprot id: Q05590
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4.

99287:STM1735
gene id: 99287:STM1735
uniprot id: P65197
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

99287:STM0187
gene id: 99287:STM0187
uniprot id: Q8ZRQ6
names: Function
names: Similarity
messages: Belongs to the SfsA family.
messages: Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism.

99287:STM3409
gene id: 99287:STM3409
uniprot id: P0A2J9
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the constitutive potassium transport systems TrkG and TrkH. May regulate the transport activity of TrkG and TrkH systems. Binds to NAD(+) and NADH. In Salmonella it is required for resistance to antimicrobial peptides.
messages: The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport (By similarity).

99287:STM0346
gene id: 99287:STM0346
uniprot id: Q8ZRH3
names: Similarity
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpX family.

99287:STM1995
gene id: 99287:STM1995
uniprot id: Q8ZNS7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Membrane

99287:STM0733
gene id: 99287:STM0733
uniprot id: Q7CQX5
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

99287:STM1341
gene id: 99287:STM1341
uniprot id: Q7CQN7
names: Function
names: Similarity
messages: Belongs to the glutathione peroxidase family. BtuE subfamily.
messages: Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.

99287:STM3408
gene id: 99287:STM3408
uniprot id: Q8ZLM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

99287:STM0793
gene id: 99287:STM0793
uniprot id: P12677
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

99287:STM4127
gene id: 99287:STM4127
uniprot id: Q7CPB8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.

99287:STM3073
gene id: 99287:STM3073
uniprot id: Q8ZM66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiQ family.
messages: Membrane

99287:STM3351
gene id: 99287:STM3351
uniprot id: Q03031
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcdB/MmdB/OadB family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.

99287:STM4357
gene id: 99287:STM4357
uniprot id: Q8ZKA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

99287:STM0126
gene id: 99287:STM0126
uniprot id: Q8ZRU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

99287:STM3001
gene id: 99287:STM3001
uniprot id: Q8ZMA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

99287:STM2227
gene id: 99287:STM2227
uniprot id: Q7CQ70
names: Similarity
messages: Belongs to the UPF0352 family.

99287:STM0487
gene id: 99287:STM0487
uniprot id: P58480
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone. Has ATPase activity.

99287:STM2784
gene id: 99287:STM2784
uniprot id: Q8ZMM5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM2116
gene id: 99287:STM2116
uniprot id: Q9F7B1
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated. Seems to be phosphorylated through a cooperative two-step mechanism. First, Tyr-568 is phosphorylated in an intramolecular reaction that generates a significant increase of protein kinase activity. Then Tyr-707, Tyr-709, Tyr-710, Tyr-712 and Tyr-714 are phosphorylated in an intermolecular Tyr-568-dependent reaction (By similarity).
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Dephosphorylated and activated by wzb.
messages: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium (By similarity).

99287:STM0627
gene id: 99287:STM0627
uniprot id: Q8ZR07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuC/DcuD transporter (TC 2.A.61) family.
messages: Membrane

99287:STM0992
gene id: 99287:STM0992
uniprot id: Q8ZQB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MukF family.
messages: Interacts, and probably forms a ternary complex, with MukE and MukB via its C-terminal region. The complex formation is stimulated by calcium or magnesium. It is required for an interaction between MukE and MukB.
messages: Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.
messages: nucleoid

99287:STM2517
gene id: 99287:STM2517
uniprot id: H9L456
names: Similarity
messages: Belongs to the intimin/invasin family.

99287:STM3300
gene id: 99287:STM3300
uniprot id: Q8ZLS6
names: Similarity
messages: Belongs to the peptidase S13 family.

99287:STM4415
gene id: 99287:STM4415
uniprot id: Q8ZK67
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

99287:STM3657
gene id: 99287:STM3657
uniprot id: Q8ZL94
names: Subcellular Location Annotation
messages: Cell membrane

99287:STM3559
gene id: 99287:STM3559
uniprot id: P40819
names: Caution
names: Function
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.
messages: Putative antitoxin component of a toxin-antitoxin (TA) system; its cognate toxin is unknown.
messages: YoeB, the specific toxin against which this antitoxin acts in E.coli, is not encoded in this genome.

99287:STM1956
gene id: 99287:STM1956
uniprot id: P0A2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sigma-70 factor family. FliA subfamily.
messages: Cytoplasm
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes. May regulate the expression of genes involved in virulence.

99287:STM0683
gene id: 99287:STM0683
uniprot id: Q8ZQX8
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

99287:STM4510
gene id: 99287:STM4510
uniprot id: Q8ZJZ9
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

99287:STM3551
gene id: 99287:STM3551
uniprot id: Q8ZLF7
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

99287:STM3440
gene id: 99287:STM3440
uniprot id: P60446
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

99287:STM1360
gene id: 99287:STM1360
uniprot id: Q8ZPR3
names: Subcellular Location Annotation
messages: Membrane

99287:STM0468
gene id: 99287:STM0468
uniprot id: Q8ZRB0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.
messages: Membrane

99287:STM3407
gene id: 99287:STM3407
uniprot id: Q8ZLM6
names: Domain
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.
messages: Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-binding site and the C-terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction.

99287:STM2899
gene id: 99287:STM2899
uniprot id: P69343
names: Function
names: Induction
messages: Transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE.
messages: Transcriptionally activated by HilA.

99287:PSLT045
gene id: 99287:PSLT045
uniprot id: H9L467
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

99287:STM1786
gene id: 99287:STM1786
uniprot id: Q8ZP28
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

99287:STM3619
gene id: 99287:STM3619
uniprot id: Q93IN2
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated by bis-(3'-5') cyclic diguanylic acid (c-di-GMP).
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix.
messages: Cell inner membrane
messages: There are two conserved domains in the globular part of the protein: the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site.

99287:STM3199
gene id: 99287:STM3199
uniprot id: Q8ZLY7
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

99287:STM3908
gene id: 99287:STM3908
uniprot id: P0A2Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm
messages: This protein activates the transcription of the IlvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression.

99287:STM2649
gene id: 99287:STM2649
uniprot id: Q8ZMX4
names: Similarity
messages: Belongs to the thioredoxin family.

99287:STM4425
gene id: 99287:STM4425
uniprot id: Q8ZK57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family.
messages: Homotetramer.
messages: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).

99287:STM4459
gene id: 99287:STM4459
uniprot id: P08421
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

99287:STM0101
gene id: 99287:STM0101
uniprot id: P06190
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldolase class II family. AraD/FucA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction).

99287:PSLT067
gene id: 99287:PSLT067
uniprot id: Q93GP6
names: Similarity
messages: Belongs to the UPF0401 family.

99287:STM1800
gene id: 99287:STM1800
uniprot id: Q8ZP18
names: Similarity
messages: Belongs to the peptidase S66 family.

99287:STM4169
gene id: 99287:STM4169
uniprot id: P0A1U4
names: Similarity
messages: To H.influenzae HI_0431.

99287:STM2029
gene id: 99287:STM2029
uniprot id: P0A2G9
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A.

99287:STM4130
gene id: 99287:STM4130
uniprot id: P37409
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
messages: Cell outer membrane
messages: Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.

99287:STM3200
gene id: 99287:STM3200
uniprot id: Q7CPR9
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

99287:STM1430
gene id: 99287:STM1430
uniprot id: O68446
names: Domain
names: Function
names: Subunit
messages: Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.
messages: Homodimer.
messages: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.

99287:STM4361
gene id: 99287:STM4361
uniprot id: P0A1R0
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Cells display drastically reduced virulence in vitro and in vivo. Mice infected with the deletion mutant show no signs of illness during the course of the experiment. This suggests that the mutation results in defects in either invasion of intestinal epithelial cells, macrophage survival, or both.
messages: Hfq expression was decreased during the space flight and expression of 64 genes of the hfq regulon was altered. Likewise, several small RNAs that interact with hfq were differentially regulated during the flight (PubMed:17901201).
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Plays a central regulatory role in the microbial response to space flight conditions. Is essential for virulence and is required for efficient invasion of non-phagocytic cells.

99287:STM0431
gene id: 99287:STM0431
uniprot id: P96060
names: Caution
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
messages: Homodimer.
messages: Induced when inorganic phosphate is limiting; this is controlled by PhoB.
messages: Involved in phosphonate degradation.
messages: Maps to a phosphate-starvation-inducible locus previously known as psiC.
messages: The crystal structure does not show the Schiff base that is expected to form between Lys-194 and the pyridoxal phosphate cofactor.
messages: Thr-243 of one partner binds the pyridoxal phosphate moiety of the other.

99287:STM2095
gene id: 99287:STM2095
uniprot id: P26393
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Is the first of four enzymes commited to biosynthesis of dTDP-L-rhamnose in S.typhimurium LT2. Is also able to convert non natural substrates such as a wide array of alpha-D-hexopyranosyl, deoxy-alpha-D-glucopyranosyl, aminodeoxy-alpha-D-hexopyranosyl and acetamidodeoxy-alpha-D-hexopyranosyl phosphates to their corresponding dTDP- and UDP-nucleotide sugars.
messages: Homotetramer.
messages: The position of the magnesium ion observed in the crystallographic structure is different from that observed in the structure of E.coli RmlA2 (RffH) and does not seem to correspond to the binding site for the catalytically essential magnesium ion. Therefore, we choose to propagate in the feature lines the positions found in the E.coli structure.

99287:STM2299
gene id: 99287:STM2299
uniprot id: O52325
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity).
messages: Homohexamer, formed by a dimer of trimers.
messages: In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: In the N-terminal section; belongs to the Fmt family. UDP-L-Ara4N formyltransferase subfamily.
messages: Induced by BasR.

99287:STM1111
gene id: 99287:STM1111
uniprot id: Q7CQS3
names: Function
names: Similarity
messages: Belongs to the CbpM family.
messages: Interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ.

99287:STM4275
gene id: 99287:STM4275
uniprot id: Q8ZKF6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Required for acetate recapture but not for acetate excretion when this organism is grown on ethanolamine (PubMed:16272400).
messages: Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.
messages: Monomer.

99287:STM2863
gene id: 99287:STM2863
uniprot id: H9L4A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

99287:STM3636
gene id: 99287:STM3636
uniprot id: P43664
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM0808
gene id: 99287:STM0808
uniprot id: Q8ZQP8
names: Subcellular Location Annotation
messages: Membrane

99287:STM1545
gene id: 99287:STM1545
uniprot id: Q8ZPG4
names: Subcellular Location Annotation
messages: Membrane

99287:STM2818
gene id: 99287:STM2818
uniprot id: O68838
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

99287:STM3194
gene id: 99287:STM3194
uniprot id: P0A1H1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DsbB family. DsbI subfamily.
messages: Cell inner membrane
messages: Interacts with DsbL.
messages: Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT.
messages: Was originally given the gene name dsbB; however another gene encoding a dsbB more closely related to that of the characterized E.coli protein bears this gene name (DSBB_SALTY, AC Q8XG65).

99287:STM3428
gene id: 99287:STM3428
uniprot id: P62405
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

99287:STM3511
gene id: 99287:STM3511
uniprot id: Q8ZLI7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NfuA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.
messages: Homodimer.
messages: Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.

99287:STM3353
gene id: 99287:STM3353
uniprot id: Q03032
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.

99287:STM2957
gene id: 99287:STM2957
uniprot id: Q8ZME1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

99287:STM0120
gene id: 99287:STM0120
uniprot id: Q8ZRU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

99287:STM2993
gene id: 99287:STM2993
uniprot id: Q8ZMB7
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

99287:STM2126
gene id: 99287:STM2126
uniprot id: Q8ZNQ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane
messages: Part of a tripartite efflux system composed of MdtA, MdtB and MdtC.

99287:STM4348
gene id: 99287:STM4348
uniprot id: Q8ZKB1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

99287:STM0937
gene id: 99287:STM0937
uniprot id: Q8ZQE8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

99287:STM1458
gene id: 99287:STM1458
uniprot id: Q8ZPM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.
messages: The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.

99287:STM1996
gene id: 99287:STM1996
uniprot id: P0CL01
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM1189
gene id: 99287:STM1189
uniprot id: P58627
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP) (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219).

99287:STM1533
gene id: 99287:STM1533
uniprot id: Q8ZPH4
names: Similarity
messages: Belongs to the HupH/HyaF family.

99287:STM1084
gene id: 99287:STM1084
uniprot id: Q7CQS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm
messages: Interacts with the TusBCD complex. Interacts with MnmA (By similarity).
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could accept sulfur from TusD (By similarity).

99287:STM2001
gene id: 99287:STM2001
uniprot id: Q8ZNS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtfA family.
messages: Cytoplasm
messages: Interacts with Mlc.
messages: Involved in the regulation of ptsG expression by binding and inactivating Mlc.

99287:STM1721
gene id: 99287:STM1721
uniprot id: O54453
names: Function
names: Similarity
messages: Belongs to the PHP family. TrpH/YciV subfamily.
messages: Exoribonuclease that catalyzes the last steps of 5S, 16S and 23S rRNA 5'-end maturation. Removes 3 nucleotides (nt) from the 5' end of 5S, 16S and 23S rRNA precursors to generate the mature 5' ends. 5S and 23S rRNA maturation occurs more efficiently and accurately on ribosomal particles as compared to free RNA. Efficiently catalyzes the hydrolysis of the 3'-phosphate from 3',5'-bis-phosphonucleotides as well as the successive hydrolysis of 5'-phosphomononucleotides from the 5'-end of short pieces of RNA and DNA, with no specificity toward the identity of the nucleotide base. Is more efficient at hydrolyzing RNA oligonucleotides than DNA oligonucleotides. This enzyme can also hydrolyze annealed DNA duplexes, albeit at a catalytic efficiency lower than that of the corresponding single-stranded oligonucleotides.

99287:STM4232
gene id: 99287:STM4232
uniprot id: P26478
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Not yet known. Might function in the uptake of a still unidentified substrate.
messages: Periplasm
messages: To E.coli MalM.

99287:STM3656
gene id: 99287:STM3656
uniprot id: Q8ZL95
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

99287:STM3804
gene id: 99287:STM3804
uniprot id: Q8ZL06
names: Subcellular Location Annotation
messages: Membrane

99287:STM2488
gene id: 99287:STM2488
uniprot id: Q8ZN72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamC family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

99287:STM3087
gene id: 99287:STM3087
uniprot id: Q7CPU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgB family.
messages: Cytoplasm

99287:STM3571
gene id: 99287:STM3571
uniprot id: Q8ZLE9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Contains an acidic N-terminal A domain, a central N domain and a C-terminal GTPase G domain that can bind and hydrolyze GTP. Contains at least two lipid-binding sites. The first site contains the first 14 amino acids (helix 1) and the second binding site is an amphipathic alpha-helix located at the interface between the A- and the N-domain (helix 2).
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

99287:STM1143
gene id: 99287:STM1143
uniprot id: P0A1E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgA/CsgB family.
messages: Curlin is the structural subunit of the curli. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers.
messages: Fimbrium

99287:STM0574
gene id: 99287:STM0574
uniprot id: Q8ZR48
names: Subcellular Location Annotation
messages: Membrane

99287:STM2037
gene id: 99287:STM2037
uniprot id: P37451
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: By propanediol aerobically and anaerobically, under control of PocR, Arc and Crp. Has 2 promoters.
messages: Cell inner membrane
messages: No visible phenotype, not required for BMC formation (PubMed:8071226, PubMed:9352910). Reduced levels of PocR protein; pocR is transcribed in part from the pduF promoters (PubMed:7559322).
messages: Probably facilitates diffusion of 1,2-propanediol (1,2-PD) into the cell (Probable). Modeling suggests active transport of 1,2-PD is required at low extracellular concentrations to allow maximal growth and saturation of PduP/PduQ within the bacterial microcompartment (BMC); this protein may be the cellular transporter (Probable).
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.

99287:STM0165
gene id: 99287:STM0165
uniprot id: Q8ZRS4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

99287:STM1924
gene id: 99287:STM1924
uniprot id: O52222
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FlhC family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (Probable).
messages: Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers (Probable). YdiV binds to FlhD which inhibits the ability of FlhC(2)FlhD(4) to bind DNA.

99287:STM2567
gene id: 99287:STM2567
uniprot id: Q8ZN28
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: In the C-terminal section; belongs to the transglycosylase Slt family.
messages: In the N-terminal section; belongs to the bacterial solute-binding protein 3 family.
messages: Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
messages: The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.

99287:STM1193
gene id: 99287:STM1193
uniprot id: O85139
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

99287:STM2912
gene id: 99287:STM2912
uniprot id: Q8ZMG9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM1164
gene id: 99287:STM1164
uniprot id: P40822
names: Subcellular Location Annotation
messages: Cell membrane

99287:STM3608
gene id: 99287:STM3608
uniprot id: Q7CPJ0
names: Subcellular Location Annotation
messages: Membrane

99287:STM1446
gene id: 99287:STM1446
uniprot id: Q8ZPN1
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

99287:STM0403
gene id: 99287:STM0403
uniprot id: Q7CR41
names: Function
names: Similarity
messages: Belongs to the AcpH family.
messages: Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.

99287:STM4184
gene id: 99287:STM4184
uniprot id: P51066
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: Homotetramer.
messages: Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.

99287:STM1063
gene id: 99287:STM1063
uniprot id: Q7CQT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PqiA family.
messages: Component of a transport pathway that contributes to membrane integrity.
messages: Membrane

99287:STM1269
gene id: 99287:STM1269
uniprot id: H9L410
names: Function
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate.

99287:STM0434
gene id: 99287:STM0434
uniprot id: P37402
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. Has a strong preference for NADPH over NADH as the electron acceptor. Pantoate, ketoisovalerate, oxaloacetate, pyruvate, 3-hydroxypyruvate, alpha-ketoglutarate, alpha-ketobutyrate, and acetaldehyde cannot serve as substrates for reduction.
messages: Cytoplasm
messages: Monomer.

99287:STM0209
gene id: 99287:STM0209
uniprot id: P26982
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1C family.
messages: Cell inner membrane
messages: DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP) (By similarity).
messages: DegP can reversibly switch between different oligomeric forms that represent inactive (6-mer) and active (12- and 24-mer) protease states. Substrate binding triggers the conversion of the resting DegP trimer and hexamer into catalytically active 12- and 24-mers. The conversion of 6-mer (DegP6) into 12-mer (DegP12) or 24-mer (DegP24) is crucial in regulating protease activity (By similarity).
messages: DegP is indispensable for bacterial survival at temperatures above 42 degrees Celsius, however is also able to digest its natural substrates in a reducing environment at temperatures as low as 20 degrees Celsius.

99287:STM0974
gene id: 99287:STM0974
uniprot id: Q7CQU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

99287:STM1284
gene id: 99287:STM1284
uniprot id: Q8ZPW3
names: Similarity
messages: Belongs to the UPF0229 family.

99287:STM2104
gene id: 99287:STM2104
uniprot id: P26341
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Involved in the biosynthesis of the capsular polysaccharide colanic acid.

99287:STM3406
gene id: 99287:STM3406
uniprot id: Q8ZLM7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

99287:STM0646
gene id: 99287:STM0646
uniprot id: Q7CQZ1
names: Similarity
messages: Belongs to the DNA polymerase HolA subunit family.

99287:STM3454
gene id: 99287:STM3454
uniprot id: Q8ZLL5
names: Similarity
messages: Belongs to the SlyX family.

99287:STM2347
gene id: 99287:STM2347
uniprot id: Q7CQ43
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

99287:STM0524
gene id: 99287:STM0524
uniprot id: Q8ZR79
names: Subcellular Location Annotation
messages: Membrane

99287:STM3205
gene id: 99287:STM3205
uniprot id: P67388
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

99287:STM3930
gene id: 99287:STM3930
uniprot id: P0A189
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily.
messages: Cell inner membrane
messages: Probable amino-acid or metabolite transport protein.

99287:STM4149
gene id: 99287:STM4149
uniprot id: P0A7K0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

99287:STM2933
gene id: 99287:STM2933
uniprot id: P63889
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

99287:STM0076
gene id: 99287:STM0076
uniprot id: P64095
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Heterodimer of FixA and FixB.
messages: Required for anaerobic carnitine reduction. May bring reductant to CaiA.

99287:STM0984
gene id: 99287:STM0984
uniprot id: P63359
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
messages: Cell inner membrane
messages: Homodimer.
messages: In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.

99287:STM2056
gene id: 99287:STM2056
uniprot id: Q9XDM6
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the EutP/PduV family.
messages: Interacts with PduU, probably via the PduU beta-barrel which is predicted by modeling to be on the exterior of the BMC.
messages: May play a role in the spatial distribution of the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation, perhaps being involved in cytoskeleton dynamics. This subunit is directly targeted to the BMC (By similarity). Might bind GTP (Probable).
messages: The 1,2-propanediol (1,2-PD) degradation bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.

99287:STM0522
gene id: 99287:STM0522
uniprot id: Q8ZR80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

99287:STM0783
gene id: 99287:STM0783
uniprot id: Q8ZQR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (ModC), two transmembrane proteins (ModB) and a solute-binding protein (ModA).

99287:STM1301
gene id: 99287:STM1301
uniprot id: Q8ZPV3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

99287:STM2757
gene id: 99287:STM2757
uniprot id: Q8ZMP7
names: Similarity
messages: Belongs to the archaeal-type GPI family.

99287:STM2921
gene id: 99287:STM2921
uniprot id: Q8ZMG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UbiX/PAD1 family. YclB subfamily.
messages: Homododecamer.
messages: Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives. Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase.

99287:STM0533
gene id: 99287:STM0533
uniprot id: Q8ZR71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

99287:STM1698
gene id: 99287:STM1698
uniprot id: Q8ZP57
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily.
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is a kinase, which is required for SPI-2 T3SS-dependent F-actin meshwork formation in infected host cells.
messages: Expression is regulated by the two-component regulatory system SsrA/SsrB.
messages: Host cytoplasm
messages: Secreted

99287:STM3750
gene id: 99287:STM3750
uniprot id: Q7CPH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

99287:STM3813
gene id: 99287:STM3813
uniprot id: Q8XFK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane
messages: Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity).

99287:STM1414
gene id: 99287:STM1414
uniprot id: P74856
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell inner membrane
messages: Component of Salmonella pathogenicity island 2 (SPI-2) type III secretion system, required for secretion of some type III-secreted effectors including the SpvB toxin.
messages: Disruption prevents SpvB-induced F-actin depolymerization in human macrophages without affecting intra-bacterial SpvB protein levels.

99287:STM1740
gene id: 99287:STM1740
uniprot id: Q8ZP48
names: Similarity
messages: Belongs to the UPF0263 family.

99287:STM2554
gene id: 99287:STM2554
uniprot id: Q7CQ09
names: Subcellular Location Annotation
messages: Membrane

99287:STM2888
gene id: 99287:STM2888
uniprot id: P40701
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.

99287:STM2546
gene id: 99287:STM2546
uniprot id: P58537
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inositol monophosphatase superfamily.
messages: Cytoplasm
messages: Homodimer. The rRNA transcription and antitermination complex (rrnTAC) consists of RNA polymerase (RNAP), NusA, NusB, NusE (rpsJ), NusG, SubB, ribosomal protein S4, DNA and precursor rRNA; S4 is more flexible than other subunits.
messages: Part of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP). It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis. This subunit may play a central role in organizing the structure.

99287:STM0535
gene id: 99287:STM0535
uniprot id: Q8ZR69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

99287:STM1921
gene id: 99287:STM1921
uniprot id: P09384
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.
messages: May have three functional domains: one for interaction with CheB and CheY, a second for regulating phosphorylation and controlling the stability of the protein, and a third for receiving input signals regulating CheA activity.
messages: Trimer or tetramer.

99287:STM1507
gene id: 99287:STM1507
uniprot id: Q8ZPI9
names: Subcellular Location Annotation
messages: Membrane

99287:STM2436
gene id: 99287:STM2436
uniprot id: P40193
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Acts as transcriptional repressor of the pdxK gene, encoding a pyridoxal kinase involved in the vitamin B6 salvage pathway. Also represses transcription of its own gene. Binds to the ptsJ-pdxK intergenic region, but does not bind pdxY and pdxH promoters. Among all six B6 vitamers, only pyridoxal 5'-phosphate (PLP) clearly binds to the protein and acts as an effector molecule for PtsJ, inducing a protein conformational change that increases affinity for DNA. Thus, PLP stabilizes protein-DNA interactions, reinforcing repression.
messages: Cells lacking this gene display a 80-fold increase in pdxK expression with respect to wild-type when grown in minimal medium. A much lower but significant 2/3-fold increase of expression is also observed for pdxY and pdxH.
messages: Homodimer in both apo- and holo-forms.
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Represses its own expression.

99287:STM4066
gene id: 99287:STM4066
uniprot id: Q8ZKR2
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Disruption of the gene prevents the efficient use of AIRs as a source of thiamine.
messages: Does not show significant conformational changes upon substrate binding.
messages: Homodimer.
messages: Phosphorylates 5-amino-1-(beta-D-ribosyl)imidazole (AIRs) to form 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole (AIR), an important intermediate in the purine and thiamine biosynthetic pathways (PubMed:12486071). It allows the use of exogenous aminoimidazole riboside (AIRs) to satisfy the cellular requirement for purines and thiamine (PubMed:12486071).
messages: Potassium may regulate kinase activity.
messages: Repressed by STM4068.

99287:STM2858
gene id: 99287:STM2858
uniprot id: Q8ZMI5
names: Similarity
messages: Belongs to the HypE family.

99287:STM3068
gene id: 99287:STM3068
uniprot id: Q7CPU6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

99287:STM0850
gene id: 99287:STM0850
uniprot id: Q8ZQM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).

99287:STM2485
gene id: 99287:STM2485
uniprot id: Q8ZN74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA cytidine acetyltransferase family. TmcA subfamily.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm

99287:STM1530
gene id: 99287:STM1530
uniprot id: Q8ZPH7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Membrane

99287:STM1994
gene id: 99287:STM1994
uniprot id: Q8ZNS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A non-essential division protein that localizes to the septal ring in low ionic strength medium.
messages: Belongs to the DrpB family.
messages: Cell inner membrane

99287:STM1199
gene id: 99287:STM1199
uniprot id: Q8ZQ13
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

99287:STM2125
gene id: 99287:STM2125
uniprot id: Q8ZNQ4
names: Similarity
messages: Belongs to the heat shock protein 70 family.

99287:STM1481
gene id: 99287:STM1481
uniprot id: Q7CQK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

99287:STM2123
gene id: 99287:STM2123
uniprot id: Q8ZNQ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.
messages: Membrane

99287:STM4384
gene id: 99287:STM4384
uniprot id: Q8ZK89
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induced by L-ascorbate. Repressed by UlaR.
messages: The PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.

99287:STM0138
gene id: 99287:STM0138
uniprot id: P67481
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA gyrase inhibitor YacG family.
messages: Binds 1 zinc ion.
messages: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
messages: Interacts with GyrB.

99287:STM4414
gene id: 99287:STM4414
uniprot id: P65748
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

99287:STM0085
gene id: 99287:STM0085
uniprot id: Q8ZRW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily.
messages: Cell inner membrane
messages: Homodimer. Interacts with KefC.
messages: Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC.

99287:STM2022
gene id: 99287:STM2022
uniprot id: Q05595
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell inner membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry. Expression of just CbiMN in E.coli confers some cobalt uptake.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity.

99287:STM4449
gene id: 99287:STM4449
uniprot id: Q7CP80
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

99287:STM0486
gene id: 99287:STM0486
uniprot id: P65992
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

99287:STM1576
gene id: 99287:STM1576
uniprot id: P37593
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane.
messages: Cell inner membrane

99287:STM2796
gene id: 99287:STM2796
uniprot id: Q7CPZ0
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

99287:STM4483
gene id: 99287:STM4483
uniprot id: Q8ZK23
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

99287:STM2780
gene id: 99287:STM2780
uniprot id: Q8ZMM8
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Contains various tandem pentapeptide repeats in the C-terminal region. The pentapeptide motif is required to efficiently recruit kinesin-1. No position is completely conserved in these repeats, whose consensus sequence is A-[DN]-[FLM]-X-X. The C-terminal 38 amino acid residues, specifically, the C-terminal motif LFNEF, are required for peripheral localization of PipB2 and redistribution of lysosomal-associated membrane protein (LAMP). The N-terminal 225 amino acid residues are sufficient for type III translocation and association with Sifs and SCVs, but not accumulation in peripheral vesicles.
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in phagocytic cells.
messages: Expression of the gene is regulated by the two-component regulatory system SsrA/SsrB. It is also activated by SlyA and controlled by the two-component regulatory system PhoP/PhoQ.
messages: Host membrane
messages: Interacts with the host kinesin light chain (KLC), a subunit of the kinesin-1 motor complex.
messages: Secreted

99287:STM3823
gene id: 99287:STM3823
uniprot id: Q8ZKZ6
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TorC/TorY family.
messages: Binds 5 heme groups per subunit.
messages: Cell inner membrane
messages: Membrane

99287:STM1779
gene id: 99287:STM1779
uniprot id: P30753
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
messages: Homodimer.

99287:STM1345
gene id: 99287:STM1345
uniprot id: Q8ZPS5
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

99287:STM0319
gene id: 99287:STM0319
uniprot id: Q7CR52
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Crl family.
messages: Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes, such as the csgBAC operon encoding the subunits of curli proteins, and BcsA, involved in cellulose biosynthesis.
messages: Cytoplasm
messages: Induced at late exponential and stationary phases, and at low temperatures.

99287:STM2039
gene id: 99287:STM2039
uniprot id: P37449
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable alpha helix (residues 6-18) probably binds to cargo enzymes, attaching them to the shell.
messages: Artificial BMCs can be made in E.coli by expressing pduA-pduB/B'-pduT-pduU-pduN-pduJ-pduK (in this order). Enzymes can be targeted to the BMC, and appear to be encapsulated within it.
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the EutL/PduB family.
messages: Has 2 BMC domains which can evolve independently of each other.
messages: Homotrimerizes to form a pseudohexamer with a central pore. The trimers pack into an array.
messages: In purified BMCs seen as a 28.0 kDa and 25.0 kDa form, both of which have been N-terminally sequenced and whose N-fMet is removed; the smaller form is called PduB'.
messages: Releases increased amounts of acetaldehyde when grown on propanediol (PubMed:16585748). Cells do not make BMCs, diol dehydratase is found in diffuse aggregates near the cell pole; it was later found this a double pduA-pduBB' deletion (PubMed:11844753). A deletion that prevents synthesis of both proteins makes no BMCs, about 20% of cells form amorphous polar bodies. Grows in an interrupted manner on 1,2-PD and vitamin B12; grows for a while then stops, then restarts as if a toxic compound was accumulating and then decreases (PubMed:21239588).
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
messages: The two proteins produced are among the major shell proteins of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation (PubMed:12923081, PubMed:21239588). Required for structural integrity of BMCs and to mitigate propionaldehyde toxicity (PubMed:21239588). The N-terminal 13 residues are important for correct assembly of the BMC shell (PubMed:28138097). The isolated BMC shell component protein ratio for J:A:B':B:K:T:U is approximately 15:10:7:6:1:1:2 (PubMed:12923081). The N-terminus of the long form (PduB) is required for correct formation of BMCs, deletions in the first 37 residues have substantially reduced levels of the major lumen enzymes. May play a major role in binding the enzyme contents to the shell (PubMed:28138097).
messages: Upon overexpression of PduB or PduB' and mixing of the resulting purified sheets with 2-ethyl-1-hexanol, will form closed shells. Enzymes (tested with endogenous BMC enzyme DDH and the peroxidase activity of cytC) can be encapsulated in the shells; the enzyme is active in the shells. The shells are permeable to a variety of compounds, showing they could be used to make protein based synthetic bioreactors.

99287:STM3575
gene id: 99287:STM3575
uniprot id: Q7CPJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

99287:STM3144
gene id: 99287:STM3144
uniprot id: P64421
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family. HybF subfamily.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

99287:STM1310
gene id: 99287:STM1310
uniprot id: Q8ZPU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

99287:STM0461
gene id: 99287:STM0461
uniprot id: Q8ZRB3
names: Subcellular Location Annotation
messages: Membrane

99287:STM3885
gene id: 99287:STM3885
uniprot id: Q8ZKV8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

99287:STM3672
gene id: 99287:STM3672
uniprot id: Q8ZL80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

99287:STM2410
gene id: 99287:STM2410
uniprot id: Q8ZN99
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.
messages: Membrane

99287:STM3147
gene id: 99287:STM3147
uniprot id: Q8ZM16
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

99287:STM4458
gene id: 99287:STM4458
uniprot id: Q7CP78
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities and to avoid they are captured by anthranilate phosphoribosyltransferase (TrpD) to generate PRA, an intermediate in the alternative pyrimidine biosynthetic (APB) pathway. Also required for full activity of IlvE which is involved in the isoleucine biosynthesis. RidA also accelerates the release of pyruvate produced by IlvA from L-serine.
messages: Belongs to the RutC family.
messages: Cells lacking this gene appear to be compromised in their ability to synthesize isoleucine. Mutation results in the partial block of at least one step in isoleucine biosynthesis subsequent to the reaction catalyzed by threonine deaminase (IlvA). Mutation is required for the dependence of the PurF-independent alternative pyrimidine biosynthesis (APB) pathway of thiamine upon the oxidative pentose phosphate pathway.
messages: Cytoplasm
messages: Homotrimer.

99287:STM3913
gene id: 99287:STM3913
uniprot id: P0A267
names: Function
names: Similarity
messages: Belongs to the GppA/Ppx family. GppA subfamily.
messages: Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.

99287:STM0668
gene id: 99287:STM0668
uniprot id: O87574
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

99287:STM1112
gene id: 99287:STM1112
uniprot id: P63263
names: Function
names: Subcellular Location Annotation
messages: DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK. Its activity is inhibited by the binding of CbpM.
messages: nucleoid

99287:STM0059
gene id: 99287:STM0059
uniprot id: Q7CR91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CitD family.
messages: Covalent carrier of the coenzyme of citrate lyase.
messages: Cytoplasm
messages: Oligomer with a subunit composition of (alpha,beta,gamma)6.

99287:STM3769
gene id: 99287:STM3769
uniprot id: Q8ZL26
names: Subcellular Location Annotation
messages: Membrane

99287:STM3542
gene id: 99287:STM3542
uniprot id: Q7CPK4
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

99287:STM3978
gene id: 99287:STM3978
uniprot id: Q9L6M0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

99287:STM0536
gene id: 99287:STM0536
uniprot id: Q8XFG8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

99287:STM0737
gene id: 99287:STM0737
uniprot id: Q7CQX4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

99287:STM0113
gene id: 99287:STM0113
uniprot id: P15875
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Inhibited by EDTA, mercuric salts and by leucine. Inhibition by leucine is non-competitive with respect to 3-methyl-2-oxobutanoate and competitive with respect to acetyl-CoA, and is more sensitive at pH 6.5 than pH 8.5.
messages: Present in a monomer-homotetramer equilibrium.

99287:STM1067
gene id: 99287:STM1067
uniprot id: P64105
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

99287:STM2241
gene id: 99287:STM2241
uniprot id: P0CE12
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRR-containing bacterial E3 ligase family.
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway.
messages: Exists in an autoinhibited state in the absence of substrate protein, due to interactions of the leucine-rich repeat domain with the catalytic domain. Is activated upon binding to a substrate protein.
messages: Host apical cell membrane
messages: Host cytoplasm
messages: Secreted
messages: The LRR (leucine-rich repeat) domain is involved in autoinhibition of the enzyme activity by interacting with the catalytic domain.
messages: Ubiquitinated in the presence of host E1 ubiquitin-activating enzyme UBA1, E2 ubiquitin-conjugating enzyme UBE2D2 and ubiquitin.

99287:STM1619
gene id: 99287:STM1619
uniprot id: Q8ZPB6
names: Function
names: Subunit
messages: Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring.
messages: Homodimer.

99287:STM2293
gene id: 99287:STM2293
uniprot id: Q8ZNF7
names: Similarity
messages: Belongs to the CinA family.

99287:STM1572
gene id: 99287:STM1572
uniprot id: P37592
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Forms pores that allow passive diffusion of small molecules across the outer membrane.
messages: Homotrimer.

99287:STM0879
gene id: 99287:STM0879
uniprot id: Q8ZQJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

99287:STM0118
gene id: 99287:STM0118
uniprot id: P0A2P8
names: Function
names: Subunit
messages: Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism.
messages: Homotetramer.

99287:STM0201
gene id: 99287:STM0201
uniprot id: O87663
names: Similarity
messages: To E.coli YfcO.

99287:STM2069
gene id: 99287:STM2069
uniprot id: Q7CQB0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM1421
gene id: 99287:STM1421
uniprot id: P96068
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Part of a type III secretion system.

99287:STM2651
gene id: 99287:STM2651
uniprot id: Q8ZMX2
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Acetylates and inactivates the acetyl-CoA synthase (Acs). Can also acetylate other central metabolic enzymes in response to environmental changes.
messages: Exhibits positive cooperativity. It may be the result of acetyl-CoA binding to two distinct sites, or the result of subunit interactions.
messages: In the N-terminal section; belongs to the acetate CoA ligase alpha subunit family.
messages: In the central section; belongs to the acetate CoA ligase beta subunit family.
messages: Monomer in the absence of acetyl-CoA. Oligomerizes to a tetrameric form in the presence of acetyl-CoA.

99287:STM0515
gene id: 99287:STM0515
uniprot id: Q8ZR87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ureidoglycolate lyase family.
messages: Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source.
messages: Homodimer.

99287:STM2300
gene id: 99287:STM2300
uniprot id: O52326
names: Function
names: Induction
names: Similarity
messages: Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.
messages: Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable).
messages: Induced by BasR.

99287:STM2047
gene id: 99287:STM2047
uniprot id: Q9XDN5
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the PduL family.
messages: Evolutionarily distinct from Pta (phosphate acetyltransferase).
messages: Involved in 1,2-propanediol (1,2-PD) utilization in the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. Also able to catalyze the reverse reaction. Also has phosphate acetyltransferase activity to a lesser extent (PubMed:17158662). Required for optimal growth on 1,2-PD when the BMC is intact. CoA is regenerated within the BMC (for use by PduP) via this enzyme, although there must also be cofactor transport across the BMC. Directly targeted to the BMC (PubMed:25962918).
messages: Monomer, when purified in the absence of the encapsulation peptide (EP, residues 1-27). The EP may influence oligomerization.
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
messages: The N-terminal 20 residues target foreign proteins (tested with eGFP) to the BMC (PubMed:25962918). Formed by 2 beta-barrels, each is capped on both ends by short alpha-helices (By similarity).
messages: There are 2 Zn(2+) ions per monomer; Zn(2+) and CoA bind inbetween the 2 domains in each monomer.
messages: Unable to ferment 1,2-PD, impaired for aerobic growth on this compound.

99287:STM4254
gene id: 99287:STM4254
uniprot id: P0A195
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Binds about 2 zinc atoms/molecule.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

99287:PSLT037
gene id: 99287:PSLT037
uniprot id: P0A2N2
names: Function
names: Similarity
messages: Belongs to the SpvD family.
messages: Not known. This protein is involved in the virulence of salmonellas.

99287:STM0212
gene id: 99287:STM0212
uniprot id: Q8ZRP5
names: Subcellular Location Annotation
messages: Membrane

99287:STM2053
gene id: 99287:STM2053
uniprot id: Q9XDM9
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A protein that aids in conversion of cob(III)alamin to cob(II)alamin and then to cob(I)alamin in the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation (PubMed:15817784, PubMed:20656910). The latter step requires PduO. No free cob(I)alamin is released, suggesting a complex is formed with PduO that finishes conversion to adenosylcobalamin. PduS and PduO allow regeneration of the adenosylcobalamin cofactor within the BMC (PubMed:15817784). Another study showed reduction of cob(II)alamin to cob(I)alamin in the absence of PduO. Both reactions require NADH. Cyanocobalamin (CN-Cbl) is not a substrate for the first reaction (PubMed:20656910). Cobalamin reduction probably occurs spontaneously in the presence of free reduced flavin nucleotides, this protein may be involved in electron transfer for this reduction (Probable).
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the PduS cobalamin reductase family.
messages: Binds 2 [4Fe-4S] clusters (By similarity). The two centers are coupled but must possess different redox potentials (By similarity).
messages: Binds one FMN non-covalently per monomer.
messages: Grows more slowly and to a lower cell density than wild-type.
messages: Monomeric when purified anaerobically, dimeric under aerobic conditions (PubMed:20656910). Forms a complex with PduO (PubMed:15817784, PubMed:20656910). Interacts with PduT, probably via the N-terminus of PduS (By similarity).
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.

99287:STM4560
gene id: 99287:STM4560
uniprot id: Q56121
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

99287:STM3714
gene id: 99287:STM3714
uniprot id: P26470
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS.
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Membrane

99287:STM2838
gene id: 99287:STM2838
uniprot id: Q8ZMJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SIS family. GutQ/KpsF subfamily.
messages: Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). It is also able of sustaining the biosynthetic pathway of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs) (By similarity).
messages: Homotetramer.

99287:STM3710
gene id: 99287:STM3710
uniprot id: P67912
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

99287:STM1629
gene id: 99287:STM1629
uniprot id: Q8ZPA6
names: Function
names: Subcellular Location Annotation
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.
messages: Host cytoplasm
messages: Secreted

99287:STM2215
gene id: 99287:STM2215
uniprot id: Q8ZNK1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.
messages: Membrane

99287:STM2968
gene id: 99287:STM2968
uniprot id: Q8ZMD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Homodimer.

99287:STM3997
gene id: 99287:STM3997
uniprot id: P0A2H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis (By similarity).

99287:STM0739
gene id: 99287:STM0739
uniprot id: Q8ZQU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

99287:STM2430
gene id: 99287:STM2430
uniprot id: P0A1E3
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: O-acetyl-L-serine causes the CysE-CysK complex to dissociate in the absence of hydrogen sulfide.
messages: Part of the cysteine synthase complex formed at a ratio of 2 copies of this protein and 1 copy of serine acetyltransferase (cysE). The complex reversibly dissociates in the presence of O-acetyl-L-serine but in the absence of hydrogen sulfide (PubMed:4977445). Homodimer (PubMed:10452898, PubMed:11023792, PubMed:9761678).
messages: Two cysteine synthase enzymes are found, this enzyme and CysM; both catalyze the same reaction. Cysteine synthase B (CysM) can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product.

99287:STM2351
gene id: 99287:STM2351
uniprot id: P02915
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Isolated, soluble HisP has a very low ATPase activity (PubMed:9520394). ATPase activity is slightly increased in the presence of HisM and HisQ, and strongly increased when HisJ is also present (PubMed:9520394).
messages: Part of the ABC transporter complex HisPMQJ involved in histidine transport (PubMed:7050725, PubMed:9520394). Is also part of the ABC transporter complex HisPMQ-ArgT involved in lysine/arginine/ornithine transport (PubMed:24021237). Shows ATPase activity (PubMed:9520394). Responsible for energy coupling to the transport system (PubMed:9520394).
messages: The HisPMQJ complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ) (PubMed:7050725, PubMed:2033074, PubMed:9520394). The HisPMQ-ArgT complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (ArgT) (PubMed:24021237).

99287:STM2180
gene id: 99287:STM2180
uniprot id: Q7CQ82
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM0890
gene id: 99287:STM0890
uniprot id: Q8XG72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

99287:STM3857
gene id: 99287:STM3857
uniprot id: Q8ZKX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PstS family.
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

99287:STM3419
gene id: 99287:STM3419
uniprot id: P0A7Q8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

99287:STM0435
gene id: 99287:STM0435
uniprot id: Q8ZRC9
names: Similarity
names: Subunit
messages: Belongs to the UPF0234 family.
messages: Monomer.

99287:STM0148
gene id: 99287:STM0148
uniprot id: H9L4B4
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

99287:PSLT073
gene id: 99287:PSLT073
uniprot id: Q93GP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the relaxosome TraM family.
messages: Cytoplasm

99287:PSLT106
gene id: 99287:PSLT106
uniprot id: Q93GL6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. A site-specific tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Its toxic effects are neutralized by expression of cognate antitoxin VapB.

99287:STM3114
gene id: 99287:STM3114
uniprot id: Q8ZM37
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

99287:STM0195
gene id: 99287:STM0195
uniprot id: H9L482
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM0963
gene id: 99287:STM0963
uniprot id: P67563
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

99287:STM1003
gene id: 99287:STM1003
uniprot id: Q8ZQB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

99287:STM1511
gene id: 99287:STM1511
uniprot id: P69936
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Homotetramer.
messages: NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP-dependent oxidation of L-allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate. Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid. YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradation since both are able to detoxify malonic semialdehyde.

99287:STM3171
gene id: 99287:STM3171
uniprot id: P40800
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YiaN/YgiK family.
messages: Cell inner membrane

99287:STM4269
gene id: 99287:STM4269
uniprot id: Q8ZKG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

99287:STM2174
gene id: 99287:STM2174
uniprot id: Q8ZNM4
names: Function
names: Similarity
messages: Belongs to the Dus family. DusC subfamily.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs.

99287:STM4175
gene id: 99287:STM4175
uniprot id: P26977
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the GARS family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Monomer.

99287:STM3770
gene id: 99287:STM3770
uniprot id: Q7CPG4
names: Subcellular Location Annotation
messages: Membrane

99287:STM2661
gene id: 99287:STM2661
uniprot id: Q8ZMW9
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

99287:STM0424
gene id: 99287:STM0424
uniprot id: P67458
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

99287:STM1713
gene id: 99287:STM1713
uniprot id: P06614
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm
messages: Homotetramer.
messages: This protein is a positive regulator of gene expression for the cysteine regulon, a system of 10 or more loci involved in the biosynthesis of L-cysteine from inorganic sulfate. The inducer for CysB is N-acetylserine. CysB inhibits its own transcription.

99287:STM0402
gene id: 99287:STM0402
uniprot id: Q7CR42
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

99287:STM1225
gene id: 99287:STM1225
uniprot id: P0CL49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine.

99287:STM1771
gene id: 99287:STM1771
uniprot id: Q8ZP32
names: Subcellular Location Annotation
messages: Membrane

99287:STM2663
gene id: 99287:STM2663
uniprot id: Q8ZMW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery.

99287:STM4404
gene id: 99287:STM4404
uniprot id: P26264
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.
messages: Strongly repressed during nitrogen excess.

99287:STM0094
gene id: 99287:STM0094
uniprot id: Q7CR86
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
messages: The transmembrane domain is a dimerization domain.

99287:STM0559
gene id: 99287:STM0559
uniprot id: Q7CR05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gtrA family.
messages: Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane.
messages: Membrane

99287:STM4157
gene id: 99287:STM4157
uniprot id: Q9L9J3
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Adopts a GT-A fold and acts as an inverting enzyme that converts the alpha-configuration in the UDP-N-acetyl-alpha-D-glucosamine donor to the beta configuration in the N-linked (GlcNAc) arginine product.
messages: Auto-glycosylated: arginine GlcNAcylation is required for activity toward death domain-containing host target proteins.
messages: Belongs to the glycosyltransferase NleB family.
messages: Protein-arginine N-acetylglucosaminyltransferase activity is inhibited by 100066N compound (flavone analog) and 102644N compound (a substituted isoxazole).
messages: Protein-arginine N-acetylglucosaminyltransferase effector that disrupts TNF signaling in infected cells, including NF-kappa-B signaling, apoptosis and necroptosis (PubMed:23955153, PubMed:28522607, PubMed:28069818). Acts by catalyzing the transfer of a single N-acetylglucosamine (GlcNAc) to a conserved arginine residue in the death domain of host proteins TRADD and, to a lower extent, FADD: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions and assembly of the oligomeric TNF-alpha receptor complex, thereby disrupting TNF signaling (PubMed:23955153, PubMed:28069818). Also acts on host proteins without a death domain: catalyzes arginine GlcNAcylation of host GAPDH protein, thereby preventing GAPDH interaction with TRAF2, leading to inhibit NF-kappa-B signaling (PubMed:28522607). Catalyzes GlcNAcylation of host tubulin-folding cofactor TBCB, thereby promoting microtubule stability (PubMed:32366039). Also mediates auto-GlcNAcylation, which is required for activity toward death domain-containing host target proteins (PubMed:32366039).
messages: Secreted
messages: Transcription is dependent on PhoP/PhoQ two-component system.
messages: host cytosol

99287:STM3904
gene id: 99287:STM3904
uniprot id: P40810
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

99287:STM0215
gene id: 99287:STM0215
uniprot id: P0A1X6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

99287:STM0644
gene id: 99287:STM0644
uniprot id: P97084
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.
messages: Homodimer.

99287:STM3273
gene id: 99287:STM3273
uniprot id: Q8ZLU0
names: Function
names: Similarity
messages: Belongs to the UbiT family.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor.

99287:STM0320
gene id: 99287:STM0320
uniprot id: P30705
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gram-negative porin family.
messages: By phosphate starvation.
messages: Cell outer membrane
messages: Homotrimer.
messages: Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes.

99287:STM0484
gene id: 99287:STM0484
uniprot id: P74876
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
messages: Probably formed by programmed ribosomal frameshifting to a premature stop codon in the -1 frame at codon 430.
messages: Produced by full-length translation of the dnaX gene.
messages: Seems to interact with the delta subunit to transfer the beta subunit on the DNA.
messages: Serves as a scaffold to help in the dimerization of the core complex.
messages: The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha, epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore: (alpha,epsilon,theta)[2]-(isoform:gamma/tau)[3]-delta,delta', psi,chi-beta[4] (By similarity).

99287:STM0426
gene id: 99287:STM0426
uniprot id: P96065
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Induced when inorganic phosphate is limiting; this is controlled by PhoB.
messages: Maps to a phosphate-starvation-inducible locus previously known as psiC.
messages: Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import. Probably responsible for the translocation of the substrate across the membrane.

99287:STM1309
gene id: 99287:STM1309
uniprot id: Q8ZPU6
names: Function
messages: Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity).

99287:STM2811
gene id: 99287:STM2811
uniprot id: Q8ZML1
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Induced in response to increased extracellular osmolarity, this is the third gene of the proU operon (proV-proW-proX). Osmoregulation requires curved DNA downstream of the transcription start site in proV, which is repressed when bound by H-NS. H-NS may act indirectly to influence the local topology of the promoter (PubMed:1423593).
messages: Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Binds glycine betaine and proline betaine with high affinity.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (ProV), two transmembrane proteins (ProW) and a solute-binding protein (ProX).

99287:STM1200
gene id: 99287:STM1200
uniprot id: P65246
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

99287:STM3713
gene id: 99287:STM3713
uniprot id: P26471
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the O-antigen on the glucose(II) group of LPS.
messages: Belongs to the O-antigen polymerase family.
messages: Cell membrane

99287:STM0779
gene id: 99287:STM0779
uniprot id: Q8ZQR8
names: Similarity
messages: Belongs to the ModE family.

99287:STM3564
gene id: 99287:STM3564
uniprot id: P0A1W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leucine-binding protein family.
messages: Periplasm
messages: This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids.

99287:STM2365
gene id: 99287:STM2365
uniprot id: Q8ZNC0
names: Function
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.
messages: Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

99287:STM4084
gene id: 99287:STM4084
uniprot id: Q8ZKP5
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

99287:STM1525
gene id: 99287:STM1525
uniprot id: Q8ZPI2
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

99287:STM2304
gene id: 99287:STM2304
uniprot id: P37589
names: Function
names: Induction
names: Similarity
messages: Belongs to the PmrD family.
messages: By PhoP. Repressed by BasR.
messages: Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance.

99287:STM0692
gene id: 99287:STM0692
uniprot id: Q8ZQX2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM0258
gene id: 99287:STM0258
uniprot id: Q8ZRM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0294 family.
messages: Cytoplasm

99287:STM1493
gene id: 99287:STM1493
uniprot id: Q8ZPK2
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OsmX family.
messages: Deletion of the osmU operon eliminates the residual osmoprotection by glycine betaine in a mutant that is lacking the ProP and the ProU systems. OsmU deletion has no effect on the utilization of glycine betaine as an osmoprotectant when ProP or ProU are functional.
messages: Induced by osmotic stress. Part of the osmU operon, which consists of four genes (osmV, osmW, osmX and osmY).
messages: Part of the OsmU ABC transporter complex, which is involved in the uptake of osmoprotectants such as choline-O-sulfate and glycine betaine.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (OsmV), two transmembrane proteins (OsmW and OsmY) and a solute-binding protein (OsmX).

99287:STM4519
gene id: 99287:STM4519
uniprot id: Q8ZJZ3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

99287:STM1980
gene id: 99287:STM1980
uniprot id: P0A1L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell inner membrane
messages: Required for the assembly of the rivet at the earliest stage of flagellar biosynthesis.

99287:STM1377
gene id: 99287:STM1377
uniprot id: Q7CQN4
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Lpp family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Plays an important role in virulence (PubMed:15213144). A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane (By similarity).
messages: The integrity of the cell envelope in a lpp null mutant (double-knockout) is not affected.
messages: This gene is probably the major expressed form.
messages: cell wall

99287:STM1910
gene id: 99287:STM1910
uniprot id: P0CL14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

99287:STM0128
gene id: 99287:STM0128
uniprot id: Q8ZRU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

99287:STM1503
gene id: 99287:STM1503
uniprot id: Q7CQJ7
names: Similarity
messages: Belongs to the UPF0482 family.

99287:STM4229
gene id: 99287:STM4229
uniprot id: P19576
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE).

99287:STM3450
gene id: 99287:STM3450
uniprot id: Q8ZLL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DsrF/TusC family.
messages: Cytoplasm
messages: Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.

99287:STM2785
gene id: 99287:STM2785
uniprot id: P0CL17
names: Function
names: Induction
messages: TctD expression is regulated by catabolite repression.
messages: Transcriptional activator of the tctI tricarboxylate transport system operon.

99287:STM1959
gene id: 99287:STM1959
uniprot id: P06179
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes, fliC and fljB.
messages: Inhibited in nutrient-poor medium (at protein level).
messages: Secreted

99287:STM2971
gene id: 99287:STM2971
uniprot id: Q8ZMD0
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

99287:STM0185
gene id: 99287:STM0185
uniprot id: Q8ZRQ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

99287:STM1614
gene id: 99287:STM1614
uniprot id: Q8ZPB9
names: Subcellular Location Annotation
messages: Membrane

99287:STM0260
gene id: 99287:STM0260
uniprot id: Q7CR60
names: Similarity
messages: Belongs to the transglycosylase Slt family.

99287:STM3532
gene id: 99287:STM3532
uniprot id: Q8ZLG9
names: Similarity
messages: Belongs to the DapA family.

99287:STM1488
gene id: 99287:STM1488
uniprot id: Q8ZPK7
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

99287:STM2772
gene id: 99287:STM2772
uniprot id: P03013
names: Function
names: Similarity
messages: A DNA fragment of approximately 900 base pairs, adjacent to the fljB (H2) gene, which specifies the synthesis of phase-2 flagellin, can exist in either orientation with respect to fljB. The orientation of the inversion region controls expression of fljB. The hin gene occupies about two-thirds of the inversion region; it is required for the inversion of the fljB controlling region.
messages: Belongs to the site-specific recombinase resolvase family.

99287:STM1497
gene id: 99287:STM1497
uniprot id: Q8ZPJ8
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

99287:STM0995
gene id: 99287:STM0995
uniprot id: Q8ZQB5
names: Similarity
messages: Belongs to the YkuD family.

99287:STM1657
gene id: 99287:STM1657
uniprot id: Q8ZP86
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

99287:STM4019
gene id: 99287:STM4019
uniprot id: Q8ZKT9
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

99287:STM3321
gene id: 99287:STM3321
uniprot id: P26983
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Associates exclusively with 100S ribosomes, which are dimers of 70S ribosomes.
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
messages: During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
messages: Induced during stationary growth phase.

99287:STM1538
gene id: 99287:STM1538
uniprot id: Q8ZPH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

99287:STM0868
gene id: 99287:STM0868
uniprot id: Q8ZQK6
names: Subcellular Location Annotation
messages: Membrane

99287:STM0834
gene id: 99287:STM0834
uniprot id: Q8ZQN2
names: Subcellular Location Annotation
messages: Membrane

99287:STM1890
gene id: 99287:STM1890
uniprot id: Q8ZNV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M23B family.
messages: Membrane

99287:STM4589
gene id: 99287:STM4589
uniprot id: Q8ZJU5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM2422
gene id: 99287:STM2422
uniprot id: Q8ZN94
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

99287:STM1958
gene id: 99287:STM1958
uniprot id: Q56106
names: Function
names: Similarity
messages: Belongs to the FliB family.
messages: Post-translationally modifies flagellin by methylation of epsilon amino group of surface-exposed lysine residues.

99287:STM3063
gene id: 99287:STM3063
uniprot id: P66692
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

99287:STM1853
gene id: 99287:STM1853
uniprot id: Q8ZNY9
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Can hydrolyze phosphorylated Ser-, Thr- or Tyr-substrates in vitro. The natural substrate is unknown.
messages: Inhibited by cadmium, copper, zinc when added cobalt when added concomitantly with manganese.
messages: Neither magnesium nor calcium stimulates activity.

99287:STM1291
gene id: 99287:STM1291
uniprot id: P65449
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

99287:STM1347
gene id: 99287:STM1347
uniprot id: Q8ZPS4
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

99287:STM1898
gene id: 99287:STM1898
uniprot id: P66762
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

99287:STM0532
gene id: 99287:STM0532
uniprot id: Q8ZR72
names: Similarity
messages: Belongs to the carbamate kinase family.

99287:PSLT049
gene id: 99287:PSLT049
uniprot id: P37414
names: Similarity
messages: To phage 186 CP81.

99287:STM3795
gene id: 99287:STM3795
uniprot id: Q7CPF3
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Dimer of large and small chains.

99287:STM4195
gene id: 99287:STM4195
uniprot id: Q8ZKL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell inner membrane
messages: Transports ketopantoate, pantoate and, to a lesser extent, pantothenate into the cell. Can also transport a product of coenzyme A (CoA) degradation that serves as a precursor to CoA and enters the biosynthetic pathway between PanC and CoaBC.

99287:STM0761
gene id: 99287:STM0761
uniprot id: Q8ZQT1
names: Similarity
messages: Belongs to the class-I fumarase family.

99287:STM1766
gene id: 99287:STM1766
uniprot id: Q8ZP35
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM3951
gene id: 99287:STM3951
uniprot id: Q05311
names: Function
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.
messages: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.

99287:STM4138
gene id: 99287:STM4138
uniprot id: P37416
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
messages: Belongs to the biotin--protein ligase family.

99287:STM3401
gene id: 99287:STM3401
uniprot id: Q8ZLN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

99287:STM2291
gene id: 99287:STM2291
uniprot id: Q8ZNF9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR). Can also dehydrate L-lyxonate and L-mannonate, although less efficiently, but not 2-keto-4-hydroxyheptane-1,7-dioate.
messages: Homooctamer; tetramer of dimers.
messages: Reaction proceeds via a syn dehydration.

99287:STM1192
gene id: 99287:STM1192
uniprot id: P0A259
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

99287:STM2254
gene id: 99287:STM2254
uniprot id: P61378
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).

99287:STM1393
gene id: 99287:STM1393
uniprot id: P0CZ04
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with the mammalian NIPSNAP3A and HOOK3 proteins in infected cells.
messages: PubMed:12174087 and PubMed:12193612 report that SpiC is not translocated into the infected cell, and is localized in the bacterial cytoplasm. They show it is required for secretion of SseB and SseC virulence proteins into infected cells.
messages: Secreted
messages: Virulence protein that plays a central role in mammalian macrophage infection, by inhibiting phagosome-lysosome fusion and cellular trafficking. May act by disrupting the function of the mammalian HOOK3 protein, a protein involved in the cellular traffic.

99287:STM3749
gene id: 99287:STM3749
uniprot id: Q8ZL35
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

99287:STM4118
gene id: 99287:STM4118
uniprot id: Q7CPC0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoethanolamine transferase family. EptC/CptA subfamily.
messages: Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core.
messages: Cell inner membrane
messages: Induced by BasR.

99287:STM3404
gene id: 99287:STM3404
uniprot id: P66822
names: Similarity
messages: Belongs to the Smg family.

99287:STM4087
gene id: 99287:STM4087
uniprot id: Q8ZKP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

99287:STM0225
gene id: 99287:STM0225
uniprot id: P0A1Z2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Skp family.
messages: Has been reported to be located in the outer membrane.
messages: Homotrimer.
messages: Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm.
messages: Periplasm

99287:STM0980
gene id: 99287:STM0980
uniprot id: Q8ZQC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

99287:STM1573
gene id: 99287:STM1573
uniprot id: Q8ZPE3
names: Similarity
messages: Belongs to the Gfa family.

99287:STM1338
gene id: 99287:STM1338
uniprot id: P15434
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

99287:STM2674
gene id: 99287:STM2674
uniprot id: P36245
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

99287:STM0203
gene id: 99287:STM0203
uniprot id: Q8ZRP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.

99287:STM0036
gene id: 99287:STM0036
uniprot id: Q8ZRZ6
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

99287:STM0546
gene id: 99287:STM0546
uniprot id: P37924
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Involved in the export and assembly of FimA fimbrial subunits across the outer membrane.

99287:STM4035
gene id: 99287:STM4035
uniprot id: Q7CPC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

99287:STM0490
gene id: 99287:STM0490
uniprot id: Q8ZRA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Cytoplasm
messages: Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity.
messages: Homodimer. Interacts with MalT and MelA.

99287:STM3050
gene id: 99287:STM3050
uniprot id: Q8ZM79
names: Function
names: Similarity
messages: Belongs to the N(4)-acetylcytidine amidohydrolase family.
messages: Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).

99287:STM0329
gene id: 99287:STM0329
uniprot id: Q8ZRJ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

99287:STM3375
gene id: 99287:STM3375
uniprot id: Q8ZLP2
names: Similarity
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.

99287:STM1617
gene id: 99287:STM1617
uniprot id: Q8ZPB7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

99287:STM1333
gene id: 99287:STM1333
uniprot id: Q8ZPS9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

99287:STM0583
gene id: 99287:STM0583
uniprot id: Q8ZR41
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
messages: Homodimer.

99287:STM1171
gene id: 99287:STM1171
uniprot id: P0A1J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgN family.
messages: Cytoplasm
messages: Required for the efficient initiation of filament assembly.

99287:STM0447
gene id: 99287:STM0447
uniprot id: P66932
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

99287:STM4152
gene id: 99287:STM4152
uniprot id: P0A299
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Acetylation of Ser-2 converts L12 to L7.
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

99287:STM1725
gene id: 99287:STM1725
uniprot id: P00910
names: Function
names: Similarity
names: Subunit
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.
messages: Monomer.

99287:STM0576
gene id: 99287:STM0576
uniprot id: Q8ZR46
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM0055
gene id: 99287:STM0055
uniprot id: Q03030
names: Function
names: Subunit
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Composed of three chains (alpha, beta, and gamma).

99287:STM1937
gene id: 99287:STM1937
uniprot id: Q7CQC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
messages: Cell inner membrane
messages: Involved in transporting aromatic amino acids across the cytoplasmic membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

99287:STM0078
gene id: 99287:STM0078
uniprot id: Q8ZRW8
names: Function
names: Similarity
messages: Belongs to the bacterial-type ferredoxin family. FixX subfamily.
messages: Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster-containing protein (By similarity).

99287:STM0494
gene id: 99287:STM0494
uniprot id: P06196
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Periplasm

99287:STM4052
gene id: 99287:STM4052
uniprot id: Q8ZKS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

99287:STM4294
gene id: 99287:STM4294
uniprot id: P60066
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Cell inner membrane
messages: Each subunit has 12 transmembrane (TM) helices; TM1 and TM6 are interrupted by short non-helical Gly-rich loops in the middle of their transmembrane spans. TM11 and TM12 provide most of the homodimerization interface. Each subunit has a central cavity which probably binds substrate.
messages: Homodimer; each subunit has its own individual transport capacity.
messages: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach (Probable). Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons (PubMed:19578361). Probably undergoes several conformational states in order to translocate the substrate across the membrane; keeps the substrate accessible to only 1 side of the membrane at a time by opening and closing 3 membrane-internal gates (By similarity).
messages: Maximum induction requires anaerobiosis, acidic conditions and tyrosine.

99287:STM0397
gene id: 99287:STM0397
uniprot id: Q7CR43
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

99287:STM3805
gene id: 99287:STM3805
uniprot id: Q8ZL05
names: Subcellular Location Annotation
messages: Membrane

99287:STM2578
gene id: 99287:STM2578
uniprot id: Q8ZN19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

99287:STM2063
gene id: 99287:STM2063
uniprot id: P37602
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhsC family.
messages: Cell inner membrane
messages: Component of the PhsABC thiosulfate reductase that catalyzes the reduction of thiosulfate to sulfite and hydrogen sulfide, with menaquinol as the sole electron donor. Proton motive force (PMF) is required to drive transmembrane electron transfer within the reductase. The PhsC subunit anchors the complex to the membrane and contains the site for menaquinol oxidation.
messages: Composed of three subunits: PhsA, PhsB and PhsC.

99287:STM2536
gene id: 99287:STM2536
uniprot id: Q9RF52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Probably plays an important role in intracellular peptide degradation.

99287:STM1972
gene id: 99287:STM1972
uniprot id: P26465
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cytoplasm
messages: Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage.

99287:STM0780
gene id: 99287:STM0780
uniprot id: Q7CQW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.
messages: Belongs to the AcrZ family.
messages: Cell inner membrane
messages: Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts directly with AcrB.

99287:STM4187
gene id: 99287:STM4187
uniprot id: P17430
names: Function
messages: Regulation of the glyoxylate bypass operon, which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase.

99287:STM3346
gene id: 99287:STM3346
uniprot id: Q8ZLQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AFG1 ATPase family. ZapE subfamily.
messages: Cytoplasm
messages: Interacts with FtsZ.
messages: Reduces the stability of FtsZ polymers in the presence of ATP.

99287:STM2374
gene id: 99287:STM2374
uniprot id: Q8ZNB6
names: Similarity
messages: Belongs to the ner transcriptional regulatory family.

99287:STM4508
gene id: 99287:STM4508
uniprot id: Q8ZK00
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

99287:STM1772
gene id: 99287:STM1772
uniprot id: P65215
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

99287:STM1208
gene id: 99287:STM1208
uniprot id: Q8ZQ07
names: Function
names: Similarity
messages: Belongs to the thiamine kinase family.
messages: Catalyzes the phosphorylation of thiamine to thiamine phosphate.

99287:STM0382
gene id: 99287:STM0382
uniprot id: Q8ZRF1
names: Subcellular Location Annotation
messages: Membrane

99287:STM0723
gene id: 99287:STM0723
uniprot id: Q8ZQV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

99287:STM0048
gene id: 99287:STM0048
uniprot id: Q7CR92
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

99287:STM2775
gene id: 99287:STM2775
uniprot id: Q8ZMN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Fes family.
messages: Cytoplasm

99287:STM3250
gene id: 99287:STM3250
uniprot id: Q8ZLV7
names: Function
names: Similarity
messages: Belongs to the UxaA family.
messages: Catalyzes the dehydration of galactarate to form 5-dehydro-4-deoxy-D-glucarate (5-KDG).

99287:STM4342
gene id: 99287:STM4342
uniprot id: Q8ZKB4
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

99287:STM2859
gene id: 99287:STM2859
uniprot id: P0CL46
names: Function
messages: Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes.

99287:STM3315
gene id: 99287:STM3315
uniprot id: Q8ZLS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SIS family. GutQ/KpsF subfamily.
messages: Homotetramer.
messages: Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity).

99287:STM4077
gene id: 99287:STM4077
uniprot id: Q8ZKQ1
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor.
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable).
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

99287:STM3570
gene id: 99287:STM3570
uniprot id: Q7CPJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

99287:STM0622
gene id: 99287:STM0622
uniprot id: Q8ZR11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.
messages: Cytoplasm
messages: Oligomer with a subunit composition of (alpha,beta,gamma)6.
messages: Represents a citryl-ACP lyase.

99287:STM0086
gene id: 99287:STM0086
uniprot id: Q8ZRW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefC subfamily.
messages: Cell inner membrane
messages: Homodimer. Interacts with the regulatory subunit KefF.
messages: Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.

99287:STM2362
gene id: 99287:STM2362
uniprot id: Q8ZNC2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM2817
gene id: 99287:STM2817
uniprot id: Q9L4T0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) (By similarity).

99287:STM1406
gene id: 99287:STM1406
uniprot id: H9L4C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SctF family.
messages: Cell surface
messages: Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (By similarity). SsaG/SctF2 forms the external needle filament that protrudes from the bacterial surface (By similarity).
messages: During infection, can induce innate immune responses (PubMed:24643544). The needle proteins interact with host TLR2 or TLR4, and induce signaling by NF-kappa-B and/or AP-1 (PubMed:24643544). This activation is MyD88 dependent and results in increased expression of cytokines, including TNF-alpha, IL-6 and IL-8 (PubMed:24643544).
messages: Secreted
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569). This subunit polymerizes and forms the helical needle filament (By similarity).

99287:STM0772
gene id: 99287:STM0772
uniprot id: Q8ZQS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

99287:STM1097
gene id: 99287:STM1097
uniprot id: Q8ZQ52
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: HIU hydrolysis also occurs spontaneously, but more slowly.
messages: Homotetramer.
messages: Periplasm

99287:STM2462
gene id: 99287:STM2462
uniprot id: P0A206
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the EutJ family.
messages: Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: May protect ethanolamine ammonia-lyase (EAL, eutB-eutC) from inhibition, may functin in assembling the bacterial microcompartment and/or in refolding EAL, suggesting it may have chaperone activity (Probable). Overexpression of eutJ and eutS in E.coli leads to multiple BMC-like structures; eutS expression alone leads to 1 BMC-like structure per cell (PubMed:27063436).
messages: Not required for aerobic growth on ethanolamine (EA) supplemented with cobalamin (vitamin B12). A double eutJ-eutG deletion is not required for growth in the above conditions. A double eutG-eutH deletion is not required for growth in the above conditions. Slightly attenuated in a mouse model of infection (PubMed:10464203). A non-polar deletion mutant grows on EA from pH 5.5 to pH 8.0, but does not grow at pH 8.5, no change in acetaldehyde release on EA plus vitamin B12 (PubMed:16585748).
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).

99287:STM3725
gene id: 99287:STM3725
uniprot id: Q8ZL48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

99287:STM4385
gene id: 99287:STM4385
uniprot id: Q8ZK88
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induced by L-ascorbate. Repressed by UlaR.
messages: The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.

99287:STM4544
gene id: 99287:STM4544
uniprot id: P67524
names: Function
names: Similarity
messages: Belongs to the DnaT family.
messages: This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.

99287:PSLT051
gene id: 99287:PSLT051
uniprot id: P37415
names: Function
names: Similarity
messages: A low activity DNA endonuclease probably yielding 3'-hydroxyl ends. Involved in RecA-independent recombination and horizontal gene transfer (By similarity).
messages: Belongs to the Rpn/YhgA-like nuclease family.

99287:STM4388
gene id: 99287:STM4388
uniprot id: Q8ZK85
names: Cofactor
names: Function
names: Induction
names: Similarity
messages: Belongs to the aldolase class II family. AraD/FucA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization.
messages: Induced by L-ascorbate. Repressed by UlaR.

99287:STM3429
gene id: 99287:STM3429
uniprot id: P60626
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

99287:STM2758
gene id: 99287:STM2758
uniprot id: Q8ZMP6
names: Subcellular Location Annotation
messages: Membrane

99287:STM2556
gene id: 99287:STM2556
uniprot id: P26353
names: Cofactor
names: Domain
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the globin family. Two-domain flavohemoproteins subfamily.
messages: Binds 1 FAD per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: By nitric oxide.
messages: Consists of two distinct domains; an N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.
messages: Monomer.

99287:STM2251
gene id: 99287:STM2251
uniprot id: Q7CQ65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

99287:STM4568
gene id: 99287:STM4568
uniprot id: Q7CP66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.
messages: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

99287:STM0176
gene id: 99287:STM0176
uniprot id: Q8ZRR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

99287:STM2097
gene id: 99287:STM2097
uniprot id: P26391
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction.
messages: Homodimer.

99287:STM1780
gene id: 99287:STM1780
uniprot id: P0A1V6
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by inorganic phosphate (PubMed:4306285, PubMed:4324215). In addition to form a complex with ATP, Mg(2+) also acts as a cofactor (PubMed:4306285, PubMed:4324215). Strongly inhibited by ADP (or Mg-ADP) through competitive binding at the activation site and at a specific allosteric site (PubMed:4324215, PubMed:4346344, PubMed:6277896). Competitively inhibited by Ca(2+) (PubMed:4324215, PubMed:4346344).
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit (Potential). Can also use Mn(2+) ions (PubMed:4306285).
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: This enzyme uses a steady state ordered mechanism, where Mg(2+) binds first, followed by Mg-ATP and lastly, ribose 5-phosphate.

99287:STM0599
gene id: 99287:STM0599
uniprot id: Q8ZR29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioesterase PaaI family.
messages: Cytoplasm
messages: Homotetramer. Dimer of dimers. Interacts specifically with the aryl carrier protein (ArCP) domain of EntB.
messages: Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules.

99287:STM3427
gene id: 99287:STM3427
uniprot id: P66409
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

99287:STM0714
gene id: 99287:STM0714
uniprot id: Q8ZQV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

99287:STM1306
gene id: 99287:STM1306
uniprot id: Q8ZPU9
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the succinylarginine dihydrolase family.
messages: By nitrogen and carbon starvation, and arginine, via the ArgR and Crp transcriptional regulators.
messages: Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
messages: Homodimer.

99287:STM1163
gene id: 99287:STM1163
uniprot id: P06204
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

99287:STM1366
gene id: 99287:STM1366
uniprot id: Q8ZPQ8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thioesterase PaaI family.
messages: Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA).
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM2465
gene id: 99287:STM2465
uniprot id: P41791
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Artificial BMCs can be made in E.coli by expressing eutK, eutL, eutM, eutN, eutS (eutSMNLK) or eutS alone. Cargo proteins can be targeted to them and beta-galactosidase (lacZ) was active within the BMC, showing the BMC allows passage of substrate into the interior. This can lead to the development of tailored BMCs for specific metabolic reactions (PubMed:22428024, PubMed:27063436). The addition of eutQ to the eutSMNLK construct results in biogenesis of multiple BMCs (PubMed:27063436). Can incorporate into the pdu BMC where it alters growth, suggesting fine-tuning metabolite flux by using different BMC components is possible (PubMed:28585808).
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.
messages: Can be used as a self-assembling protein scaffold for synthetic biology. Overexpressed, purified protein with a SpyCatcher tag added to the C-terminus yields self-assembling fibrils that are stable at pH 5-9 and up to 50 degrees Celsius. Addition of SpyTagged cargo proteins leads to isopeptide bond formation between the scaffold and cargo proteins, colocalizing and stabilizing the cargo proteins and reducing the time for the reaction to make maximimal product.
messages: Essential, it cannot be deleted when the 17-gene operon is otherwise intact, possibly due to polar effects on downstream genes (PubMed:7868611). Not required for cobalamin-dependent degradation of ethanolamine (EA) when polar effects are removed. A double eutD-eutM deletion is also not required for growth in the above conditions (PubMed:10464203). A double eutM-eutN strain grows as well as wild-type on EA and cyanocobalamin, but a quadruple eutL-eutK eutM-eutN strain does not grow (PubMed:16291677). A non-polar deletion mutant grows on EA at pH 5.5 to pH 7.0 but not at pH 8.0 or pH 8.5, releases increased amounts of acetaldehyde on EA plus vitamin B12. Preventing acetaldehyde vapor loss allows growth up to pH 8.5 (PubMed:16585748).
messages: Expression of the eut operon allows this bacteria to use ethanolamine as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Homohexamer with a central pore of up to 8.6 Angstroms diameter. The hexamers pack into a two-dimensional array (By similarity). Interacts with EutQ; a probably cytoplasm-facing helix (Val-49 to Gln-64) interacts with N-terminus of EutQ (PubMed:27063436).
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).
messages: Probably a major component of the bacterial microcompartment (BMC) shell dedicated to ethanolamine degradation (PubMed:22428024, PubMed:27063436). Each homohexamer has a central pore with an opening of up to 8.6 Angstroms. A positively-charged funnel leads to the pore from each side of the hexamer. The pore probably allows metabolite passage into and out of the BMC (By similarity). Expression of eutK, eutL, eutM, eutN, eutS (eutSMNLK) in E.coli leads to formation of a single BMC. Expression alone leads to thick filaments that interfere with cell separation (PubMed:22428024, PubMed:27063436). Coexpression of eutQ with eutSMNLK permits E.coli to make cells with more than one mobile BMC, as is usual in vivo. May play a role in BMC shell biogenesis (PubMed:27063436). Can replace homolog pduA in the pdu operon, cells grow better than wild-type on 1,2-propanediol and vitamin B12. Protein is incorporated into the pdu BMC microcompartment (PubMed:28585808).
messages: The ethanolamine (EA) catabolic bacterial microcompartment (BMC) probably concentrates low levels of ethanolamine catabolic enzymes, concentrates volatile reaction intermediates, keeps the level of toxic acetaldehyde low, generates enough acetyl-CoA to support cell growth, and maintains a pool of free coenzyme A (CoA) and NAD (Probable) (PubMed:16585748). Deletion of BMC genes (eutK, eutL, eutM) restores growth of eutD deletions, suggesting there are dedicated pools of coenzyme A (CoA) and NAD in the BMC (PubMed:23585538).
messages: The need for a bacterial microcompartment in EA metabolism can be bypassed by increasing the levels of EAL and an acetaldehyde dehydrogenase (not necessarily EutE).

99287:STM3497
gene id: 99287:STM3497
uniprot id: Q8ZLJ5
names: Similarity
messages: Belongs to the HSP15 family.

99287:STM0617
gene id: 99287:STM0617
uniprot id: Q8ZR16
names: Similarity
messages: Belongs to the RNase T2 family.

99287:STM0758
gene id: 99287:STM0758
uniprot id: Q8ZQT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cell inner membrane
messages: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc.

99287:STM3435
gene id: 99287:STM3435
uniprot id: P61179
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

99287:STM1534
gene id: 99287:STM1534
uniprot id: Q7CQJ3
names: Similarity
messages: Belongs to the HupG/HyaE family.

99287:STM1296
gene id: 99287:STM1296
uniprot id: Q7CQP4
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

99287:STM4021
gene id: 99287:STM4021
uniprot id: Q8ZKT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the N-acylglucosamine 2-epimerase family.
messages: Catalyzes the isomerization of sulfoquinovose (SQ) to 6-deoxy-6-sulfo-D-fructose (SF) (PubMed:33791429). Can also catalyze the interconversion of SQ and sulforhamnose (SR) (PubMed:33791429). In vitro, can also catalyze the interconversion of mannose, fructose and glucose, but has extremely low activity with glucose (PubMed:18328504).
messages: Homohexamer.

99287:STM0244
gene id: 99287:STM0244
uniprot id: Q7CR61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RcsF family.
messages: Cell outer membrane
messages: Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects.

99287:STM2911
gene id: 99287:STM2911
uniprot id: Q8ZMH0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM4089
gene id: 99287:STM4089
uniprot id: P67651
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraA family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.
messages: Homotrimer. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB.

99287:STM1427
gene id: 99287:STM1427
uniprot id: Q7CQL0
names: Similarity
messages: Belongs to the CFA/CMAS family.

99287:STM3976
gene id: 99287:STM3976
uniprot id: Q7BM06
uniprot id: Q9L6M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair.
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.
messages: Cytoplasm
messages: Monomer.

99287:STM2675
gene id: 99287:STM2675
uniprot id: P0A2B5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

99287:STM1428
gene id: 99287:STM1428
uniprot id: Q8ZPP0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

99287:STM1977
gene id: 99287:STM1977
uniprot id: P26419
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell inner membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).

99287:STM2667
gene id: 99287:STM2667
uniprot id: Q8ZMW7
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

99287:STM3158
gene id: 99287:STM3158
uniprot id: Q7CPS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

99287:STM0122
gene id: 99287:STM0122
uniprot id: Q7CR83
names: Function
names: Similarity
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

99287:STM4151
gene id: 99287:STM4151
uniprot id: P0A297
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex (By similarity).
messages: Protein L10 is also a translational repressor protein. It controls the translation of the rplJL-rpoBC operon by binding to its mRNA.
messages: Ribosomal protein L8 appears to be an aggregate of ribosomal proteins L7/L12 and L10.

99287:STM0746
gene id: 99287:STM0746
uniprot id: Q7CQX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

99287:STM1429
gene id: 99287:STM1429
uniprot id: Q8ZPN9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM2545
gene id: 99287:STM2545
uniprot id: P66974
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

99287:STM3453
gene id: 99287:STM3453
uniprot id: Q8ZLL6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

99287:STM3924
gene id: 99287:STM3924
uniprot id: Q9L6R1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WecD family.
messages: Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).
messages: Homodimer.

99287:STM2530
gene id: 99287:STM2530
uniprot id: Q8ZN48
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

99287:STM3062
gene id: 99287:STM3062
uniprot id: Q8ZM69
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

99287:STM4174
gene id: 99287:STM4174
uniprot id: P25852
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon (By similarity).
messages: Phosphorylated by ZraS.
messages: Was originally thought to be involved in the regulation of the labile hydrogenase activity.

99287:STM4095
gene id: 99287:STM4095
uniprot id: Q8ZKN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

99287:STM0312
gene id: 99287:STM0312
uniprot id: Q7CR54
names: Similarity
messages: Belongs to the YkuD family.

99287:STM3349
gene id: 99287:STM3349
uniprot id: Q7CPN3
names: Similarity
messages: Belongs to the peptidase S1C family.

99287:STM4277
gene id: 99287:STM4277
uniprot id: Q8ZKF5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-552 family.
messages: Binds 1 Ca(2+) ion per monomer.
messages: Binds 5 heme c groups covalently per monomer.
messages: Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
messages: Periplasm

99287:STM0750
gene id: 99287:STM0750
uniprot id: Q8ZQT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

99287:STM4306
gene id: 99287:STM4306
uniprot id: Q8ZKD6
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

99287:STM1175
gene id: 99287:STM1175
uniprot id: P0A1I7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

99287:STM3319
gene id: 99287:STM3319
uniprot id: Q7CPN9
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

99287:STM0107
gene id: 99287:STM0107
uniprot id: Q8ZRV1
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Expression is repressed by thiamine.
messages: Insertions in thiBPQ cause a defect in the transport of both thiamine and TPP.
messages: Part of the ABC transporter complex ThiBPQ involved in thiamine import (PubMed:9535878). Probably responsible for the translocation of the substrate across the membrane (Probable). Is also involved in thiamine pyrophosphate transport (PubMed:9535878).
messages: The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).

99287:STM3287
gene id: 99287:STM3287
uniprot id: P37430
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

99287:STM3020
gene id: 99287:STM3020
uniprot id: Q8ZM96
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM0380
gene id: 99287:STM0380
uniprot id: P0A1F0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

99287:STM0976
gene id: 99287:STM0976
uniprot id: Q8ZQC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

99287:STM0035
gene id: 99287:STM0035
uniprot id: Q8ZRZ7
names: Similarity
messages: Belongs to the sulfatase family.

99287:STM1374
gene id: 99287:STM1374
uniprot id: Q8ZPQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SufE family.
messages: Cytoplasm
messages: Homodimer. Interacts with SufS.
messages: Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.

99287:STM0734
gene id: 99287:STM0734
uniprot id: Q8ZQU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.
messages: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.

99287:STM3055
gene id: 99287:STM3055
uniprot id: P64222
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

99287:STM4536
gene id: 99287:STM4536
uniprot id: Q8ZJY1
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM1512
gene id: 99287:STM1512
uniprot id: P27236
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides.
messages: Unable to grow on N-acetyl-Ala-Ala-Ala as a nitrogen source.

99287:STM3111
gene id: 99287:STM3111
uniprot id: P67617
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. Necessary to maintain high levels of aconitase under oxidative stress.

99287:STM3339
gene id: 99287:STM3339
uniprot id: Q8ZLQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
messages: Cytoplasm
messages: Homotetramer.

99287:STM2253
gene id: 99287:STM2253
uniprot id: Q8XF64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

99287:STM3766
gene id: 99287:STM3766
uniprot id: Q8ZL29
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

99287:STM3337
gene id: 99287:STM3337
uniprot id: Q8ZLQ7
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

99287:STM0664
gene id: 99287:STM0664
uniprot id: Q7CQY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

99287:STM3333
gene id: 99287:STM3333
uniprot id: Q8ZLR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

99287:STM2043
gene id: 99287:STM2043
uniprot id: O31043
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the DdrA/PduG family.
messages: Cells lacking this gene are defective in aerobic degradation of propanediol.
messages: Forms a heterotetramer PduG(2)/PduH(2).
messages: Large subunit of the propanediol dehydratase-reactivating factor (DDR), which reactivates suicidally inhibited adenosylcobalamin-dependent propanediol dehydratase (diol dehydratase, DDH) found in the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. Reactivates inactivated DDH in the presence of ATP, Mg(2+) and free adenosylcobalamin (AdoCbl), by mediating the exchange of the tightly bound damaged cofactor AdoCbl for a free intact one. This subunit contains the adenosine nucleotide binding site.
messages: Originally suggested to encode a cobalamin adenosyl transferase.
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.

99287:STM1960
gene id: 99287:STM1960
uniprot id: P16328
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

99287:STM1879
gene id: 99287:STM1879
uniprot id: Q8ZNW9
names: Similarity
messages: Belongs to the peptidase S9A family.

99287:STM1840
gene id: 99287:STM1840
uniprot id: Q7CQD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MgrB family.
messages: Cell inner membrane
messages: May form homooligomers. Probably interacts with the periplasmic domain of PhoQ.
messages: PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing. MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.

99287:STM1069
gene id: 99287:STM1069
uniprot id: Q8ZQ68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MatP family.
messages: Cytoplasm
messages: Homodimer.
messages: Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.

99287:STM2424
gene id: 99287:STM2424
uniprot id: Q8ZN92
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM4424
gene id: 99287:STM4424
uniprot id: Q8ZK58
names: Function
names: Similarity
messages: Belongs to the IolE/MocC family.
messages: Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).

99287:STM1368
gene id: 99287:STM1368
uniprot id: Q8ZPQ6
names: Subcellular Location Annotation
messages: Membrane

99287:STM1467
gene id: 99287:STM1467
uniprot id: P25081
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide.

99287:STM1531
gene id: 99287:STM1531
uniprot id: Q8ZPH6
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

99287:STM1246
gene id: 99287:STM1246
uniprot id: P23988
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. Ail family.
messages: Cell outer membrane
messages: Essential for full virulence and survival within macrophages.

99287:STM1459
gene id: 99287:STM1459
uniprot id: P65542
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.
messages: The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.

99287:STM3855
gene id: 99287:STM3855
uniprot id: Q8ZKX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

99287:STM4038
gene id: 99287:STM4038
uniprot id: Q8ZKS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

99287:STM0953
gene id: 99287:STM0953
uniprot id: P69226
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

99287:STM0460
gene id: 99287:STM0460
uniprot id: Q8ZRB4
names: Subcellular Location Annotation
messages: Membrane

99287:STM1371
gene id: 99287:STM1371
uniprot id: Q8ZPQ3
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

99287:STM2835
gene id: 99287:STM2835
uniprot id: Q8ZMK0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

99287:STM3521
gene id: 99287:STM3521
uniprot id: Q8ZLH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

99287:STM1387
gene id: 99287:STM1387
uniprot id: Q7CQM8
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system TtrR/TtrS, which is required for synthesis of tetrathionate reductase. Positively regulates transcription of the ttrBCA operon. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut.
messages: Phosphorylated by TtrS.

99287:STM4473
gene id: 99287:STM4473
uniprot id: Q08021
names: Similarity
messages: Belongs to the acetyltransferase family.

99287:STM3709
gene id: 99287:STM3709
uniprot id: P37419
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

99287:STM2281
gene id: 99287:STM2281
uniprot id: Q8ZNG8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM2205
gene id: 99287:STM2205
uniprot id: Q7CQ78
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

99287:STM2130
gene id: 99287:STM2130
uniprot id: Q8ZNP9
names: Subcellular Location Annotation
messages: Cell inner membrane

99287:STM3584
gene id: 99287:STM3584
uniprot id: P64413
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Homotetramer.
messages: Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.

99287:STM1400
gene id: 99287:STM1400
uniprot id: O84947
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SctE/SipB/YopB family.
messages: Cell surface
messages: Component of the type III secretion system 2 (SPI-2 T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (Probable). SseC/SctE2 and SseD/SctB2 are inserted into the host membrane where they form a pore and allow the translocation of effector proteins into the cytosol of target cells (Probable).
messages: Host membrane
messages: Mutant is severely attenuated in virulence (PubMed:9786193). Disruption prevents SpvB-induced F-actin depolymerization in human macrophages without affecting intra-bacterial SpvB protein levels (PubMed:18248436).
messages: Required for the translocation of SPI-2 effector proteins (PubMed:11567004). Required for systemic Salmonella infection of the mouse (PubMed:11159962). Essential for SpvB-induced actin depolymerization in the host cell cytoplasm (PubMed:18248436).
messages: Secreted
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569). This subunit is involved in the formation of a pore, called the translocon, in host membrane (Probable). May form a complex with SseB and SseD/SctB2 (PubMed:11567004). SseB is required for correct localization of SseC/SctE2 on the bacterial cell surface (PubMed:11567004).

99287:STM2316
gene id: 99287:STM2316
uniprot id: Q8ZNE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

99287:STM3026
gene id: 99287:STM3026
uniprot id: Q8ZM92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM1295
gene id: 99287:STM1295
uniprot id: Q8ZPV6
names: Similarity
messages: Belongs to the peptidase S49 family.

99287:STM0115
gene id: 99287:STM0115
uniprot id: P46924
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM1477
gene id: 99287:STM1477
uniprot id: Q7CQK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Membrane

99287:STM0022
gene id: 99287:STM0022
uniprot id: H9L483
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

99287:STM3644
gene id: 99287:STM3644
uniprot id: Q8ZLA2
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

99287:STM0228
gene id: 99287:STM0228
uniprot id: P32200
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

99287:STM3135
gene id: 99287:STM3135
uniprot id: P0A2M7
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

99287:STM3964
gene id: 99287:STM3964
uniprot id: P0A2Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression.
messages: Cytoplasm

99287:STM1795
gene id: 99287:STM1795
uniprot id: Q8ZP21
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

99287:STM1974
gene id: 99287:STM1974
uniprot id: P26416
names: Domain
names: Function
names: Similarity
messages: Belongs to the FliK family.
messages: Controls the length of the flagellar hook.
messages: Two-domain protein with the central portion of the sequence acting as a hinge or connector between the two.

99287:STM3405
gene id: 99287:STM3405
uniprot id: Q8ZLM8
names: Similarity
messages: Belongs to the DprA/Smf family.

99287:STM0272
gene id: 99287:STM0272
uniprot id: Q93IS9
names: Similarity
messages: Belongs to the ClpA/ClpB family.

99287:STM3212
gene id: 99287:STM3212
uniprot id: Q7CPR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
messages: Binds DNA as a monomer.
messages: Cytoplasm
messages: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.

99287:STM1962
gene id: 99287:STM1962
uniprot id: P0A1N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FliT family.
messages: Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
messages: Homodimer. Interacts with FliD and FlhC.
messages: cytosol

99287:STM0552
gene id: 99287:STM0552
uniprot id: P37928
names: Subcellular Location Annotation
messages: Fimbrium

99287:STM3466
gene id: 99287:STM3466
uniprot id: P0A2T6
names: Domain
names: Function
names: Subunit
messages: A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity).
messages: Homodimer, which upon binding cAMP is able to bind DNA. Binds the N- and C-terminus of RNA polymerase subunit RpoA and sigma-70 (RpoD) (By similarity).
messages: The N-terminal domain binds cAMP and is responsible for homodimerization, while the C-terminal domain binds DNA when cAMP is bound.

99287:STM0163
gene id: 99287:STM0163
uniprot id: P58718
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxA family. PdxA2 subfamily.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP) (PubMed:27402745). Can also use 4-hydroxy-L-threonine 4-phosphate as substrate (PubMed:27294475, PubMed:27402745).
messages: Deletion mutant is unable to use D-threonate as a carbon source.
messages: Homodimer.

99287:STM4501
gene id: 99287:STM4501
uniprot id: Q7CP77
names: Similarity
messages: Belongs to the UPF0386 family.

99287:STM1157
gene id: 99287:STM1157
uniprot id: P61351
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0312 family. Type 1 subfamily.
messages: Periplasm

99287:STM2981
gene id: 99287:STM2981
uniprot id: Q7CPW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

99287:STM1862
gene id: 99287:STM1862
uniprot id: O30646
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Cell membrane

99287:STM0935
gene id: 99287:STM0935
uniprot id: Q8ZQF0
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A peripheral cell membrane enzyme that catalyzes the oxidative decarboxylation of pyruvate to form acetate and CO(2). It channels electrons from the cytoplasm to the respiratory chain at the cell membrane via ubiquinone.
messages: Belongs to the TPP enzyme family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Cell inner membrane
messages: Has 4 domains; the Pyr domain which binds the pyrimidine moiety of the thiamine pyrophosphate cofactor, the FAD-binding domain, the PP-binding domain which binds the pyrophosphate portion of thiamine pyrophosphate and the C-terminal membrane binding region. The C-terminus is held closely against the rest of the protein and covers the active site; during activation it unfolds from the rest of the protein and forms an amphipathic helix upon membrane binding, exposing the active site.
messages: Homotetramer.
messages: The C-terminus inhibits activity; it has to move for the enzyme to be active. Activated by lipid-binding, which occurs via the C-terminus.

99287:STM0301
gene id: 99287:STM0301
uniprot id: Q8ZRK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

99287:STM0631
gene id: 99287:STM0631
uniprot id: Q8ZR05
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

99287:STM3271
gene id: 99287:STM3271
uniprot id: P67349
names: Similarity
messages: Belongs to the UPF0213 family.

99287:STM3019
gene id: 99287:STM3019
uniprot id: Q8ZM97
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

99287:STM4073
gene id: 99287:STM4073
uniprot id: Q8ZKQ5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Autoregulated.
messages: Belongs to the SorC transcriptional regulatory family.
messages: Cytoplasm
messages: In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFGE operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.

99287:STM0040
gene id: 99287:STM0040
uniprot id: Q7CR95
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM2531
gene id: 99287:STM2531
uniprot id: Q8ZN47
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

99287:STM0340
gene id: 99287:STM0340
uniprot id: Q8ZRH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM4452
gene id: 99287:STM4452
uniprot id: Q9L646
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated under anaerobic conditions by NrdG, a tightly associated activase. Activation involves the formation of a glycyl radical at Gly-681.
messages: Belongs to the anaerobic ribonucleoside-triphosphate reductase family.
messages: Catalyzes the conversion of ribonucleotides into deoxyribonucleotides, which are required for DNA synthesis and repair.
messages: Forms a tetramer composed of two NrdD and two NrdG subunits.

99287:STM3077
gene id: 99287:STM3077
uniprot id: Q7CPU3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

99287:STM0175
gene id: 99287:STM0175
uniprot id: Q8ZRR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

99287:STM2449
gene id: 99287:STM2449
uniprot id: P63423
names: Similarity
messages: Belongs to the acetyltransferase family. YpeA subfamily.

99287:PSLT107
gene id: 99287:PSLT107
uniprot id: Q93GL5
names: Similarity
messages: Belongs to the VapB family.

99287:STM3871
gene id: 99287:STM3871
uniprot id: Q7CPE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

99287:STM0455
gene id: 99287:STM0455
uniprot id: Q7CR22
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

99287:STM4336
gene id: 99287:STM4336
uniprot id: Q7CP99
names: Similarity
messages: Belongs to the EcnA/EcnB lipoprotein family.

99287:STM2353
gene id: 99287:STM2353
uniprot id: P0A2I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter complex HisPMQJ involved in histidine transport (PubMed:7050725, PubMed:9520394). Is also part of the ABC transporter complex HisPMQ-ArgT involved in lysine/arginine/ornithine transport (PubMed:24021237). Probably responsible for the translocation of the substrate across the membrane (Probable). Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (PubMed:9520394).
messages: The HisPMQJ complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ) (PubMed:7050725, PubMed:2033074, PubMed:9520394). The HisPMQ-ArgT complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (ArgT) (PubMed:24021237).

99287:STM2079
gene id: 99287:STM2079
uniprot id: Q04866
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WzzB/Cld/Rol family.
messages: Cell inner membrane
messages: Confers a modal distribution of chain length on the O-antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 20.

99287:STM2428
gene id: 99287:STM2428
uniprot id: P0A2N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
messages: Interacts with FtsZ via their C-terminal domains.

99287:STM3586
gene id: 99287:STM3586
uniprot id: Q8ZLE0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM3764
gene id: 99287:STM3764
uniprot id: P0CI70
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Cell inner membrane
messages: Not required for Mg(2+) influx by MgtB.
messages: Part of the mgtC/mgtB operon. Induced by low extracellular levels of Mg(2+). Transcriptionally regulated by extracellular magnesium via the two-component regulatory system PhoQ/PhoP.
messages: Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase.

99287:STM3363
gene id: 99287:STM3363
uniprot id: Q7CPM9
names: Similarity
messages: Belongs to the barstar family.

99287:STM3117
gene id: 99287:STM3117
uniprot id: Q8ZM36
names: Function
names: Induction
messages: Is critically involved in promoting the replication of S.typhimurium cells inside host macrophages, suggesting a role in the establishment of bacterial colonization within macrophages. May be involved in the biosynthesis and modification of the peptidoglycan layer of the cell wall.
messages: Up-regulated following infection of host macrophages.

99287:PSLT103
gene id: 99287:PSLT103
uniprot id: Q93GL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TraT lipoprotein family.
messages: Cell outer membrane
messages: Membrane
messages: Responsible for preventing unproductive conjugation between bacteria carrying like plasmids.

99287:STM2460
gene id: 99287:STM2460
uniprot id: P41796
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EutH family.
messages: Cell inner membrane
messages: Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).
messages: Probably involved in the diffusion of protonated ethanolamine (EA) into the cell at low pH. At low pH most EA is protonated, and this permease becomes necessary (Probable). Contributes to bacterial survival and replication in acidified macrophage vacuoles, but not to bacterial uptake by macrophages (PubMed:29531136).
messages: Unable to grow with ethanolamine (EA) as sole carbon source. Slightly attenuated in a mouse model of infection (PubMed:7868611). A double eutG-eutH deletion is not impaired for aerobic growth on EA supplemented with cobalamin (vitamin B12) (PubMed:10464203). Cells are unable to grow on EA at low pH (PubMed:15466042). A non-polar deletion mutant does not grow on EA at pH 5.5 or pH 8.5, poorly at pH 6.0 but wild-type at pH 7.0 and pH 8.0, slight decrease in acetaldehyde release on EA plus vitamin B12 (PubMed:16585748). About 25% reduction in survival in mouse macrophage assays. Bacterial growth is not enhanced by exogenous EA in macrophage survival assays. Decreased survival in mouse intraperitoneal infection, no phenotype in mouse colitis infections (PubMed:29531136).

99287:STM3236
gene id: 99287:STM3236
uniprot id: Q8ZLW6
names: Similarity
messages: Belongs to the pirin family.

99287:STM0202
gene id: 99287:STM0202
uniprot id: P0CL07
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

99287:STM2841
gene id: 99287:STM2841
uniprot id: Q8ZMJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase family.
messages: Cytoplasm
messages: One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase.

99287:STM0495
gene id: 99287:STM0495
uniprot id: P37174
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.
messages: Cytoplasm
messages: Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity.
messages: Reaction mechanism involves exclusion of catalytic water from the active site and substrate-mediated catalysis: the sulfhydryl side chain of the Cys substrate acts as a nucleophile and attacks the carbonyl center of the ester bond, leading to the cleavage of the Cys-tRNA ester bond and formation of a cyclic cysteine thiolactone intermediate. In contrast, the INS editing domain of ProRS catalyzes Ala-tRNA(Pro) hydrolysis via nucleophilic attack by a catalytic water molecule (By similarity).

99287:STM2783
gene id: 99287:STM2783
uniprot id: Q9FA48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA subfamily.
messages: Cell membrane
messages: Efflux system for nickel and cobalt.
messages: Membrane

99287:STM2839
gene id: 99287:STM2839
uniprot id: Q8ZMJ8
names: Function
messages: Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54.

99287:STM1278
gene id: 99287:STM1278
uniprot id: Q8ZPW9
names: Subcellular Location Annotation
messages: Membrane

99287:STM2642
gene id: 99287:STM2642
uniprot id: Q8ZMX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

99287:STM0309
gene id: 99287:STM0309
uniprot id: Q8ZRJ7
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Catalyzes the dehydrogenation of acyl-coenzymes A (acyl-CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for S.typhimurium to utilize medium- and long-chain fatty acids as sole carbon sources for growth. Is needed for bacterial survival during carbone-source starvation.
messages: Cells lacking this gene show undetectable in vivo beta-oxidation levels, and are unable to grow on oleate or decanoate as a sole carbon and energy source, in contrast to the wild-type parent strain.
messages: Is under the negative control of the global regulator FadR and the positive control of the cAMP:cAMP receptor protein (cAMP:CRP) as well as the alarmone ppGpp. Is induced under carbon-source starvation and in the presence of the long-chain fatty acid oleate. Induction during carbon starvation is cAMP:CRP-dependent and sigma(S)-independent.

99287:STM4412
gene id: 99287:STM4412
uniprot id: Q8ZK69
names: Subcellular Location Annotation
messages: Membrane

99287:STM4120
gene id: 99287:STM4120
uniprot id: Q8ZKL9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M20A family. ArgE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids. Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
messages: Cytoplasm
messages: Homodimer.

99287:STM3524
gene id: 99287:STM3524
uniprot id: Q8ZLH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Cell inner membrane
messages: Rhomboid-type serine protease that catalyzes intramembrane proteolysis.

99287:STM4364
gene id: 99287:STM4364
uniprot id: Q7CP96
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

99287:STM0149
gene id: 99287:STM0149
uniprot id: H9L454
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

99287:STM3159
gene id: 99287:STM3159
uniprot id: P0A1H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity).
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

99287:STM1132
gene id: 99287:STM1132
uniprot id: Q8ZQ32
names: Subcellular Location Annotation
messages: Membrane

99287:STM1077
gene id: 99287:STM1077
uniprot id: P62362
names: Similarity
messages: Belongs to the UPF0319 family.

99287:STM1353
gene id: 99287:STM1353
uniprot id: Q8ZPR9
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

99287:STM2320
gene id: 99287:STM2320
uniprot id: Q7CQ52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

99287:STM3686
gene id: 99287:STM3686
uniprot id: Q8ZL67
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

99287:STM0527
gene id: 99287:STM0527
uniprot id: Q8ZR77
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

99287:STM1577
gene id: 99287:STM1577
uniprot id: Q8ZPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

99287:STM1243
gene id: 99287:STM1243
uniprot id: P0A1D9
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM2878
gene id: 99287:STM2878
uniprot id: P74873
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear.
messages: Forms a complex with SicP. Binds host RAC1.
messages: Host cytoplasm
messages: In the N-terminal section; belongs to the YopE family.
messages: Requires SicP as a chaperone for its stability and for secretion. The structure of the SptP-SicP complex contains four molecules of the chaperone SicP, aligned in a linear fashion and arranged in two sets of tightly bound homodimers that bind two SptP molecules. The SicP homodimers do not interact with each other, but are held together by a molecular interface formed between two SptP molecules. The chaperone-binding domain of SptP does not adopt a globular fold for interaction with SicP. Each SptP molecule is wrapped around by three SicP chaperones (two chaperones from one homodimer and a third one from the opposite homodimer pair). SptP interacts with SicP chaperone dimers mainly through four regions of its chaperone-binding domain.
messages: Secreted
messages: The tyrosine phosphatase activity is inhibited by sodium vanadate.

99287:STM3214
gene id: 99287:STM3214
uniprot id: Q8ZLY1
names: Similarity
messages: Belongs to the SIP oxidoreductase family.

99287:STM2363
gene id: 99287:STM2363
uniprot id: Q7CQ42
names: Subcellular Location Annotation
messages: Membrane

99287:STM1663
gene id: 99287:STM1663
uniprot id: Q8ZP83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

99287:STM4235
gene id: 99287:STM4235
uniprot id: Q8ZKH9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Cell inner membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

99287:STM0640
gene id: 99287:STM0640
uniprot id: Q8ZR00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

99287:STM3285
gene id: 99287:STM3285
uniprot id: Q8ZLT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

99287:STM1788
gene id: 99287:STM1788
uniprot id: Q8ZP26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

99287:STM2041
gene id: 99287:STM2041
uniprot id: O31041
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium (PubMed:10498708). By either propanediol or glycerol.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the diol/glycerol dehydratase medium subunit family.
messages: Cells lacking this gene are defective in aerobic degradation of propanediol and display no propanediol dehydratase activity. A triple pduC-pduD-pduE deletion releases no acetaldehyde when grown on propanediol (PubMed:16585748).
messages: Inhibited by glycerol.
messages: Part of the PduCDE complex that catalyzes the dehydration of 1,2-propanediol (1,2-PD) to propionaldehyde. Required for S.typhimurium growth on 1,2-PD as the sole carbon and energy source (Probable) (PubMed:9023178). This subunit is directly targeted to the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation, and is also responsible for targeting the other 2 subunits (pduC and pduE) (PubMed:21821773, PubMed:26283792).
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
messages: The first 18 residues targets this enzyme and foreign proteins (tested with GST and eGFP) to the BMC. The cargo is only detected by Western blot in broken shells, strongly suggesting this protein is normally found inside the BMC and not on its exterior (PubMed:21821773, PubMed:26283792). PduD and PduP compete for encapsulation in BMCs, suggesting PduD also binds to PduA and/or PduJ (PubMed:26283792).
messages: The propanediol dehydratase enzyme is a heterotrimeric complex composed of a large (PduC), a medium (PduD) and a small (PduE) subunit.

99287:STM2976
gene id: 99287:STM2976
uniprot id: Q8ZMC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the L-fucose isomerase family.
messages: Converts the aldose L-fucose into the corresponding ketose L-fuculose.
messages: Cytoplasm
messages: Homohexamer.

99287:STM3092
gene id: 99287:STM3092
uniprot id: P60190
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SprT family.
messages: Binds 1 zinc ion.
messages: Cytoplasm

99287:STM0142
gene id: 99287:STM0142
uniprot id: Q8ZRT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

99287:STM1232
gene id: 99287:STM1232
uniprot id: Q8ZPZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

99287:STM3514
gene id: 99287:STM3514
uniprot id: Q8ZLI4
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

99287:PSLT011
gene id: 99287:PSLT011
uniprot id: H9L443
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

99287:STM3426
gene id: 99287:STM3426
uniprot id: P0A7X0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12 (By similarity).

99287:STM2360
gene id: 99287:STM2360
uniprot id: Q8ZNC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
messages: Catalyzes the decarboxylation of D-ornithine and D-lysine (PubMed:29024617, PubMed:30699288). Ornithine is likely the physiological substrate (PubMed:29024617). Has no detectable diaminopimelate decarboxylase activity in vitro (PubMed:29024617).
messages: Homodimer.

99287:STM0067
gene id: 99287:STM0067
uniprot id: P14846
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

99287:STM2384
gene id: 99287:STM2384
uniprot id: P58729
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

99287:STM2480
gene id: 99287:STM2480
uniprot id: Q8ZN78
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM0934
gene id: 99287:STM0934
uniprot id: Q8ZQF1
names: Similarity
names: Subunit
messages: Belongs to the threonine aldolase family.
messages: Homotetramer.

99287:STM0807
gene id: 99287:STM0807
uniprot id: Q8ZQP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

99287:STM2152
gene id: 99287:STM2152
uniprot id: Q7CQ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM4581
gene id: 99287:STM4581
uniprot id: Q8ZJU9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

99287:STM3168
gene id: 99287:STM3168
uniprot id: Q8ZM03
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

99287:STM3787
gene id: 99287:STM3787
uniprot id: P27670
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Cell inner membrane
messages: External glucose-6-phosphate induces the expression of the UHP-region.
messages: Mediates the exchange of external hexose 6-phosphate and internal inorganic phosphate.

99287:STM1574
gene id: 99287:STM1574
uniprot id: P37594
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Cell inner membrane
messages: Major efflux pump for acriflavine and other quaternary ammonium compounds (QACs). Also required for resistance to methyl viologen (By similarity).

99287:STM1834
gene id: 99287:STM1834
uniprot id: Q8ZP00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell inner membrane
messages: Probably functions as a manganese efflux pump.

99287:STM0093
gene id: 99287:STM0093
uniprot id: Q8ZRW0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA.
messages: Contains two intramolecular disulfide bonds.
messages: Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.

99287:STM1305
gene id: 99287:STM1305
uniprot id: Q8ZPV0
names: Function
names: Induction
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family. AstD subfamily.
messages: By nitrogen and carbon starvation, and arginine, via the ArgR and Crp transcriptional regulators.
messages: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.

99287:STM3717
gene id: 99287:STM3717
uniprot id: P19817
names: Function
names: Similarity
messages: Adds the glucose(II) group on the galactose(I) group of LPS.
messages: Belongs to the glycosyltransferase 8 family.

99287:STM3952
gene id: 99287:STM3952
uniprot id: P0A2R8
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell inner membrane
messages: Constitutively expressed.
messages: Homopentamer. In the absence of Mg(2+), interactions between subunits are weakened, and dimers, trimers and tetramers can be observed in vitro (By similarity). Homotetramer (PubMed:15231793).
messages: Inhibited by cation hexaammines.
messages: Is the dominant magnesium transport system under laboratory growth conditions.
messages: Mediates both influx and efflux of magnesium ions (PubMed:3536881, PubMed:2548998, PubMed:2670893, PubMed:9786860, PubMed:10601252, PubMed:10748031). Can also mediate cobalt and nickel uptake, albeit only at extracellular concentrations that are toxic to the cell (PubMed:3536881, PubMed:2670893). Does not transport iron (PubMed:15516579). Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (By similarity).
messages: The central ion permeation pathway is formed by the first transmembrane domain from each of the five subunits. Mg(2+) binding strengthens interactions between subunits and leads to the formation of a symmetrical homopentamer surrounding a closed ion permeation pathway. Co(2+) binding also induces a conformation change. Low Mg(2+) concentrations trigger both a conformation change within each subunit and a loosening of the interactions between subunits. This results in an open ion conduction pathway. In addition, this results in a less symmetrical shape of the whole complex.

99287:STM3835
gene id: 99287:STM3835
uniprot id: P0A2I3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (PubMed:16267301). Replenishes negative supercoiling downstream of highly transcribed genes to help control overall chromosomal supercoiling density (PubMed:22916023). E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB subunit is toxic in E.coli, while the E.coli copy can be expressed in S.typhimurium even though the 2 subunits have 777/804 residues identical (PubMed:17400739).
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
messages: Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

99287:STM3742
gene id: 99287:STM3742
uniprot id: Q8ZL41
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

99287:PSLT016
gene id: 99287:PSLT016
uniprot id: Q93GS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

99287:STM3239
gene id: 99287:STM3239
uniprot id: Q8ZLW4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM2442
gene id: 99287:STM2442
uniprot id: Q8ZN87
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

99287:STM1520
gene id: 99287:STM1520
uniprot id: P0A2T4
names: Function
messages: Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site.

99287:STM3423
gene id: 99287:STM3423
uniprot id: P0A7W4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Altered S5 proteins have been identified in a number of mutants. Some mutations in S5 have been shown to increase translational error frequencies.
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy. Many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations).

99287:STM4176
gene id: 99287:STM4176
uniprot id: P26978
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

99287:STM0797
gene id: 99287:STM0797
uniprot id: Q8ZQQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.

99287:STM2526
gene id: 99287:STM2526
uniprot id: P65534
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

99287:STM1059
gene id: 99287:STM1059
uniprot id: Q8ZQ75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapC family.
messages: Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
messages: Cytoplasm
messages: Interacts directly with FtsZ.

99287:STM1884
gene id: 99287:STM1884
uniprot id: Q8ZNW4
names: Similarity
names: Subunit
messages: Belongs to the KHG/KDPG aldolase family.
messages: Homotrimer.

99287:STM1789
gene id: 99287:STM1789
uniprot id: Q7CQE7
names: Similarity
messages: Belongs to the peptidase A31 family.

99287:STM0955
gene id: 99287:STM0955
uniprot id: P67613
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

99287:STM3984
gene id: 99287:STM3984
uniprot id: Q7CPD4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Splits dipeptides with a prolyl residue in the C-terminal position.

99287:STM2484
gene id: 99287:STM2484
uniprot id: Q7CQ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0370 family.
messages: Cell membrane

99287:STM4281
gene id: 99287:STM4281
uniprot id: Q8ZKF1
names: Caution
names: Function
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Possible subunit of a heme lyase.

99287:STM2520
gene id: 99287:STM2520
uniprot id: H9L451
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

99287:STM3926
gene id: 99287:STM3926
uniprot id: Q9L6Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family.
messages: Cell inner membrane
messages: Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA).
messages: Membrane
messages: Probably part of a complex composed of WzxE, WzyE and WzzE.

99287:STM4188
gene id: 99287:STM4188
uniprot id: P37586
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
messages: L-homocysteine is bound via the zinc atom.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin (By similarity).

99287:STM1435
gene id: 99287:STM1435
uniprot id: P0A1Q2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glyoxalase I family.
messages: Binds 1 nickel ion per subunit. In the homodimer, two nickel ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
messages: Homodimer.

99287:STM3304
gene id: 99287:STM3304
uniprot id: Q7CPP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

99287:STM0317
gene id: 99287:STM0317
uniprot id: P0A277
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts on guanine, xanthine and to a lesser extent hypoxanthine.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
messages: Cell inner membrane
messages: Homotetramer.
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

99287:STM1454
gene id: 99287:STM1454
uniprot id: P65540
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.
messages: The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.

99287:STM2826
gene id: 99287:STM2826
uniprot id: P69917
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

99287:STM1519
gene id: 99287:STM1519
uniprot id: P0A2S4
names: Function
names: Subunit
messages: May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF.
messages: Monomer.

99287:STM3836
gene id: 99287:STM3836
uniprot id: P24900
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).

99287:STM0321
gene id: 99287:STM0321
uniprot id: P65792
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

99287:STM2159
gene id: 99287:STM2159
uniprot id: Q8ZNN1
names: Subcellular Location Annotation
messages: Membrane

99287:STM3240
gene id: 99287:STM3240
uniprot id: Q8ZLW3
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

99287:STM4230
gene id: 99287:STM4230
uniprot id: P19566
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a repressor of mal genes. In absence of maltose, the C-terminus of MalK interacts with MalT, then MalT becomes inactive and the mal genes are not activated. In presence of maltose, MalK is tightly associated with the MalFG complex and has no affinity for MalT.
messages: Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system.
messages: Target for inducer exclusion, mediated by the unphosphorylated enzyme III of the phosphotransferase system for glucose and resulting in the inhibition of maltose transport.
messages: The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalK) and a solute-binding protein (MalE).

99287:STM0616
gene id: 99287:STM0616
uniprot id: Q7CQZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rnk family.
messages: Interacts with the RNA polymerase.
messages: May act as an anti-Gre factor.

99287:STM4137
gene id: 99287:STM4137
uniprot id: P37417
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm
messages: Monomer.

99287:STM3373
gene id: 99287:STM3373
uniprot id: Q8ZLP3
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

99287:STM3613
gene id: 99287:STM3613
uniprot id: P50335
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M16 family.
messages: Has lost the active site residues.
messages: Periplasm

99287:STM3500
gene id: 99287:STM3500
uniprot id: P41033
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by calcium.
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Monomer.

99287:STM2118
gene id: 99287:STM2118
uniprot id: Q8ZNQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BexD/CtrA/VexA family.
messages: Cell outer membrane
messages: Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium.

99287:STM2050
gene id: 99287:STM2050
uniprot id: Q8ZNR5
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the Cob(I)alamin adenosyltransferase family. PduO subfamily.
messages: Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), the cofactor for propanediol dehydratase. Found in the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation (PubMed:11160088, PubMed:15547259, PubMed:27446048, PubMed:15817784, PubMed:20656910). For adenosylcobalamin synthesis dATP can replace ATP, but no other nucleotides will substitute (PubMed:15547259). PduS and PduO allow regeneration of the adenosylcobalamin cofactor within the BMC (Probable).
messages: Decreased growth on 1,2-PD cyanocobalamin medium; no growth is seen in a double cobA-pduO deletion.
messages: Inhibited by ADP but not significantly by other nucleotides, inhibited by diphosphate and less well by triphosphate.
messages: Mn(2+) and Co(2+) are almost as active as Mg(2+) for adenosylcobalamin synthesis.
messages: Stoichiometry of heme binding is 2 PduOC:1 heme; the binding pocket is formed by a PduOC dimer. Full-length PduO also binds heme.
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
messages: The C-terminal domain (PduOC) forms stable octamers and also crystallizes as an octamer (PubMed:27446048). Forms a complex with PduS (PubMed:15817784, PubMed:20656910).
messages: The N-terminus (PduON, residues 1-185) has adenosyltransferase activity in vivo and in vitro; it partially complements a deletion mutant for growth on 1,2-PD (PubMed:15547259, PubMed:27446048). The C-terminal domain (PduOC, residues 194-336) is required for full complemention of a pduO deletion (PubMed:27446048).

99287:STM2523
gene id: 99287:STM2523
uniprot id: P58671
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

99287:STM0701
gene id: 99287:STM0701
uniprot id: Q8ZQW6
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

99287:STM3594
gene id: 99287:STM3594
uniprot id: P27237
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.
messages: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4).

99287:PSLT039
gene id: 99287:PSLT039
uniprot id: H9L477
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SpvB family.
messages: Secreted

99287:STM1706
gene id: 99287:STM1706
uniprot id: P0A2G7
names: Similarity
messages: Belongs to the SUI1 family.

99287:STM2009
gene id: 99287:STM2009
uniprot id: Q8ZNS0
names: Function
names: Similarity
messages: Belongs to the AMP nucleosidase family.
messages: Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.

99287:STM3614
gene id: 99287:STM3614
uniprot id: P50334
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell inner membrane
messages: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane.

99287:STM3308
gene id: 99287:STM3308
uniprot id: Q7CPP5
names: Similarity
messages: Belongs to the BolA/IbaG family.

99287:STM2326
gene id: 99287:STM2326
uniprot id: P0A1Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.
messages: In the N-terminal section; belongs to the complex I 30 kDa subunit family.
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

99287:STM2077
gene id: 99287:STM2077
uniprot id: P0A1R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).

99287:STM4292
gene id: 99287:STM4292
uniprot id: P36556
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well.
messages: Phosphorylated by BasS.
messages: The activity of the BasR protein is controlled at a post-transcriptional level by the PmrD protein, under low Mg(2+) concentration conditions.
messages: The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions.

99287:STM2421
gene id: 99287:STM2421
uniprot id: Q8ZN95
names: Subcellular Location Annotation
messages: Membrane

99287:STM0051
gene id: 99287:STM0051
uniprot id: Q8ZRY7
names: Function
names: Similarity
messages: Belongs to the IUNH family. RihC subfamily.
messages: Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity.

99287:STM1916
gene id: 99287:STM1916
uniprot id: P0A2D5
names: Cofactor
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Interacts (phosphorylated CheY) with CheZ (via C-terminus).
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation (By similarity). Shows autophosphatase activity which is enhanced by CheZ (PubMed:9837737).
messages: Phosphorylated by CheA or acetylated by acetyl-CoA synthetase, depending on which acetate metabolism pathway is available (By similarity). Dephosphorylated (inactivated) by CheZ.

99287:STM4046
gene id: 99287:STM4046
uniprot id: P27031
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rhamnose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
messages: Cytoplasm
messages: Homotetramer.

99287:STM1654
gene id: 99287:STM1654
uniprot id: Q8ZP88
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: Loss of cytidine thiolation in position 32 in tRNA. The deletion mutant grows at the same rate as the congenic wild-type strain, but several specific steps in the translational decoding process are affected in the mutant.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

99287:STM1973
gene id: 99287:STM1973
uniprot id: P0A1K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Flagellar protein that affects chemotactic events.

99287:STM3481
gene id: 99287:STM3481
uniprot id: P0A2P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

99287:STM2067
gene id: 99287:STM2067
uniprot id: Q8ZNR2
names: Cofactor
messages: Binds 2 Mg(2+) ions per monomer.

99287:STM1160
gene id: 99287:STM1160
uniprot id: P58525
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MSOX/MTOX family. MTOX subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the oxidative demethylation of N-methyl-L-tryptophan.
messages: Monomer.

99287:STM3384
gene id: 99287:STM3384
uniprot id: P0A2R6
names: Function
names: Similarity
messages: Belongs to the Dus family. DusB subfamily.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

99287:STM2338
gene id: 99287:STM2338
uniprot id: Q8ZND6
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically inhibited by NADH.
messages: Cytoplasm
messages: Decreased propionate kinase activity, cells grow to lower density on 1,2-PD and excrete more propionate into the medium (PubMed:12700259). A double acs-pta deletion excretes but no longer recpautres acetate (PubMed:16272400).
messages: Homohexamer.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism. Catalyzes the reversible interconversion of acetyl-CoA and acetyl phosphate. The direction of the overall reaction changes depending on growth conditions. Required for acetate recapture but not for acetate excretion when this organism is grown on ethanolamine (EA); is unable to complement an eutD deletion during growth on EA (PubMed:16272400). Works with proprionate kinase PduW to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD) (PubMed:12700259).
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).

99287:STM4245
gene id: 99287:STM4245
uniprot id: P40783
names: Similarity
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Homodimer.

99287:STM1680
gene id: 99287:STM1680
uniprot id: Q8ZP67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap.

99287:STM0970
gene id: 99287:STM0970
uniprot id: Q8ZQD0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

99287:STM1218
gene id: 99287:STM1218
uniprot id: P61482
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

99287:STM3534
gene id: 99287:STM3534
uniprot id: Q8ZLG7
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

99287:STM4093
gene id: 99287:STM4093
uniprot id: Q8ZKN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsN family.
messages: Cell inner membrane
messages: Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.
messages: Interacts with FtsA via its N-terminal cytoplasmic domain.

99287:STM3266
gene id: 99287:STM3266
uniprot id: Q8ZLU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SIS family. DiaA subfamily.
messages: Homotetramer; dimer of dimers.
messages: Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.

99287:STM4366
gene id: 99287:STM4366
uniprot id: P65882
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

99287:STM0188
gene id: 99287:STM0188
uniprot id: Q8ZRQ5
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

99287:STM2456
gene id: 99287:STM2456
uniprot id: P0A1C9
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A component of the bacterial microcompartment (BMC) shell dedicated to ethanolamine degradation (PubMed:22428024, PubMed:27063436). Forms a hexagonal trimer with 3 small channels and a large central pore that has been seen in both open and closed forms and is probably used for gated transport into and out of the BMC (By similarity). Ethanolamine-binding by the small channels has been hypothesized to stabilize the EutL central pore in a closed (non-transporting) state. An open pore is thought to be large enough to transport ATP and/or cobalamin (By similarity). Expression of eutK, eutL, eutM, eutN, eutS (eutSMNLK) in E.coli leads to formation of a single BMC (PubMed:22428024, PubMed:27063436). Coexpression of eutQ with eutSMNLK permits E.coli to make cells with more than one mobile BMC, as is usual in vivo (PubMed:27063436).
messages: Artificial BMCs can be made in E.coli by expressing eutK, eutL, eutM, eutN, eutS (eutSMNLK) or eutS alone. Cargo proteins can be targeted to them and beta-galactosidase (lacZ) was active within the BMC, showing the BMC allows passage of substrate into the interior. This can lead to the development of tailored BMCs for specific metabolic reactions (PubMed:22428024). The addition of eutQ to the eutSMNLK construct results in biogenesis of multiple BMCs (PubMed:27063436).
messages: Bacterial microcompartment
messages: Belongs to the EutL/PduB family.
messages: Expression of the eut operon allows this bacteria to use ethanolamine as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Has 2 BMC domains which can evolve independently of each other.
messages: Homotrimerizes to form a pseudohexamer.
messages: Not required for aerobic growth on ethanolamine (EA) supplemented with cobalamin (vitamin B12) (PubMed:10464203). A double eutL-eutK strain grows as well as wild-type on EA and cyanocobalamin, but a quadruple eutL-eutK eutM-eutN strain does not grow (PubMed:16291677). A non-polar deletion mutant grows on EA at pH 5.5 to pH 7.0 but not at pH 8.0 or pH 8.5, releases increased amounts of acetaldehyde on EA plus vitamin B12. Preventing acetaldehyde vapor loss allow growth up to pH 8.5 (PubMed:16585748).
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).
messages: The ethanolamine (EA) catabolic bacterial microcompartment (BMC) probably concentrates low levels of ethanolamine catabolic enzymes, concentrates volatile reaction intermediates, keeps the level of toxic acetaldehyde low, generates enough acetyl-CoA to support cell growth, and maintains a pool of free coenzyme A (CoA) and NAD (Probable) (PubMed:16585748). Deletion of BMC genes (eutK, eutL, eutM) restores growth of eutD deletions, suggesting there are dedicated pools of coenzyme A (CoA) and NAD in the BMC (PubMed:23585538).
messages: The need for a bacterial microcompartment in EA metabolism can be bypassed by increasing the levels of EAL and an acetaldehyde dehydrogenase (not necessarily EutE).

99287:STM1743
gene id: 99287:STM1743
uniprot id: P04285
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system.

99287:STM2945
gene id: 99287:STM2945
uniprot id: P40722
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SopD family.
messages: Deletion of this gene impairs bacterial replication in mouse macrophages but not in human epithelial cells.
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Contributes to replication in macrophages. Plays a role, cooperatively with SopB, in membrane fission and macropinosome formation during invasion.
messages: Host cell membrane
messages: Host cytoplasm
messages: Secreted

99287:STM1736
gene id: 99287:STM1736
uniprot id: P0A1A1
names: Function
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.
messages: Catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA.

99287:STM2408
gene id: 99287:STM2408
uniprot id: Q9RPF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell inner membrane
messages: H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake.

99287:STM3299
gene id: 99287:STM3299
uniprot id: P64281
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

99287:STM1473
gene id: 99287:STM1473
uniprot id: Q8ZPL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Membrane

99287:STM3869
gene id: 99287:STM3869
uniprot id: Q7CPE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

99287:STM4359
gene id: 99287:STM4359
uniprot id: P14161
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

99287:STM2194
gene id: 99287:STM2194
uniprot id: Q8ZNL5
names: Function
names: Similarity
messages: Belongs to the esterase D family.
messages: Serine hydrolase involved in the detoxification of formaldehyde.

99287:STM0968
gene id: 99287:STM0968
uniprot id: Q8ZQD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
messages: Cell inner membrane

99287:STM4584
gene id: 99287:STM4584
uniprot id: P39432
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

99287:STM4432
gene id: 99287:STM4432
uniprot id: Q8ZK51
names: Similarity
messages: Belongs to the TPP enzyme family.

99287:STM2560
gene id: 99287:STM2560
uniprot id: Q8ZN33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

99287:STM2096
gene id: 99287:STM2096
uniprot id: P26392
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer. Mg(2+) is important for dimerization.
messages: Homodimer.
messages: Involved in the biosynthesis of the dTDP-L-rhamnose which is an important component of lipopolysaccharide (LPS). Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well.

99287:STM0002
gene id: 99287:STM0002
uniprot id: Q8ZS19
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

99287:STM4345
gene id: 99287:STM4345
uniprot id: P0A2N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily.
messages: Cell inner membrane

99287:STM1568
gene id: 99287:STM1568
uniprot id: Q8ZPE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

99287:STM0623
gene id: 99287:STM0623
uniprot id: Q7CQZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CitD family.
messages: Covalent carrier of the coenzyme of citrate lyase.
messages: Cytoplasm
messages: Oligomer with a subunit composition of (alpha,beta,gamma)6.

99287:STM3418
gene id: 99287:STM3418
uniprot id: Q8ZLM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

99287:STM3603
gene id: 99287:STM3603
uniprot id: Q8ZLC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 37 family.
messages: Cytoplasm
messages: Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity.
messages: Monomer.

99287:STM2076
gene id: 99287:STM2076
uniprot id: P10372
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

99287:STM3238
gene id: 99287:STM3238
uniprot id: Q8ZLW5
names: Similarity
messages: Belongs to the UPF0597 family.

99287:STM0072
gene id: 99287:STM0072
uniprot id: Q8ZRX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CoA-transferase III family. CaiB subfamily.
messages: Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA (By similarity).
messages: Cytoplasm
messages: Homodimer.

99287:STM3721
gene id: 99287:STM3721
uniprot id: Q06995
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. KdkA/RfaP family.
messages: Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core.

99287:STM0836
gene id: 99287:STM0836
uniprot id: Q8ZQN1
names: Subcellular Location Annotation
messages: Membrane

99287:STM1922
gene id: 99287:STM1922
uniprot id: P55892
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MotB family.
messages: Cell inner membrane
messages: Each stator complex is composed of 4 MotA and 2 MotB subunits. 2 A subunits and 1 B subunit are thought to form a single ion channel, so that each stator complex contains two channels (By similarity).
messages: MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity).

99287:STM4387
gene id: 99287:STM4387
uniprot id: Q8ZK86
names: Function
names: Induction
names: Similarity
messages: Belongs to the L-ribulose-5-phosphate 3-epimerase family.
messages: Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization.
messages: Induced by L-ascorbate. Repressed by UlaR.

99287:STM1181
gene id: 99287:STM1181
uniprot id: P15930
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: Periplasm
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

99287:STM0351
gene id: 99287:STM0351
uniprot id: Q8ZRG9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

99287:STM1731
gene id: 99287:STM1731
uniprot id: H9L462
names: Similarity
messages: Belongs to the manganese catalase family.

99287:STM1176
gene id: 99287:STM1176
uniprot id: P0A1I9
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

99287:STM4079
gene id: 99287:STM4079
uniprot id: Q8ZKP9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LsrG family.
messages: Cytoplasm
messages: Homodimer.
messages: In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor.
messages: Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5-phosphonooxypentane-2,4-dione (P-HPD).

99287:STM4166
gene id: 99287:STM4166
uniprot id: Q9L9I5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Divalent metal cations. Mg(2+) or Mn(2+).
messages: Homodimer.
messages: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.

99287:STM1486
gene id: 99287:STM1486
uniprot id: Q7CQJ8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM2810
gene id: 99287:STM2810
uniprot id: P17327
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Induced in response to increased extracellular osmolarity, this is the second gene of the proU operon (proV-proW-proX). Osmoregulation requires curved DNA downstream of the transcription start site in proV, which is repressed when bound by H-NS. H-NS may act indirectly to influence the local topology of the promoter (PubMed:1423593).
messages: Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (ProV), two transmembrane proteins (ProW) and a solute-binding protein (ProX).

99287:STM0236
gene id: 99287:STM0236
uniprot id: Q8ZRN5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

99287:STM1379
gene id: 99287:STM1379
uniprot id: Q8ZPP8
names: Subcellular Location Annotation
messages: Membrane

99287:STM2028
gene id: 99287:STM2028
uniprot id: Q05631
names: Function
names: Similarity
messages: Belongs to the CbiG family.
messages: Catalyzes the hydrolysis of the ring A acetate delta-lactone of cobalt-precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde.

99287:STM3866
gene id: 99287:STM3866
uniprot id: Q8ZKW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

99287:STM0256
gene id: 99287:STM0256
uniprot id: Q8ZRM6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM0186
gene id: 99287:STM0186
uniprot id: P0A1G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

99287:STM0818
gene id: 99287:STM0818
uniprot id: Q8ZQP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0194 family.
messages: Periplasm

99287:STM0609
gene id: 99287:STM0609
uniprot id: P19480
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.
messages: The active site is a redox-active disulfide bond.

99287:STM4567
gene id: 99287:STM4567
uniprot id: Q8ZJV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm
messages: Homodimer.

99287:STM0994
gene id: 99287:STM0994
uniprot id: Q935S7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. MukB subfamily.
messages: Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ.
messages: Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
messages: The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer.
messages: nucleoid

99287:STM4125
gene id: 99287:STM4125
uniprot id: Q7CPB9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM3301
gene id: 99287:STM3301
uniprot id: Q8ZLS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Binds GDP with a dissociation constant of 1.7 uM and GTP with a dissociation constant of 6.5 uM.
messages: Cytoplasm
messages: Monomer (By similarity). Binds RluD (AC P65836) as well as the 30S ribosomal subunit protein S9 (PubMed:17905831).

99287:STM2685
gene id: 99287:STM2685
uniprot id: Q7CPZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

99287:STM1891
gene id: 99287:STM1891
uniprot id: Q8ZNV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 9 family.
messages: Periplasm

99287:STM0047
gene id: 99287:STM0047
uniprot id: Q8ZRY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

99287:STM0773
gene id: 99287:STM0773
uniprot id: Q8ZQS1
names: Similarity
messages: Belongs to the aldose epimerase family.

99287:STM2542
gene id: 99287:STM2542
uniprot id: Q7CQ11
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

99287:STM0628
gene id: 99287:STM0628
uniprot id: Q8ZR06
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipid A palmitoyltransferase family.
messages: Cell outer membrane
messages: Disruption of this gene increases outer membrane permeability in response to CAMP.
messages: Homodimer.
messages: Regulated by the PhoP/PhoQ two-component regulatory system.
messages: Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors. Required for resistance to cationic antimicrobial peptides (CAMPs). Modifications of lipid A with an acyl chain allow to evade host immune defenses by resisting antimicrobial peptides and attenuating the inflammatory response to infection triggered by lipopolysaccharide through the Toll-like receptor 4 (TLR4) signal transduction pathway.

99287:STM3318
gene id: 99287:STM3318
uniprot id: Q8ZLR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

99287:STM0478
gene id: 99287:STM0478
uniprot id: Q8ZRA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

99287:STM0760
gene id: 99287:STM0760
uniprot id: Q8ZQT2
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

99287:STM1832
gene id: 99287:STM1832
uniprot id: Q8ZP02
names: Subcellular Location Annotation
messages: Membrane

99287:PSLT076
gene id: 99287:PSLT076
uniprot id: H9L430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TraY family.
messages: Cytoplasm

99287:STM2094
gene id: 99287:STM2094
uniprot id: P26394
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

99287:STM1364
gene id: 99287:STM1364
uniprot id: Q8ZPR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

99287:STM4393
gene id: 99287:STM4393
uniprot id: Q8ZK81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

99287:STM0662
gene id: 99287:STM0662
uniprot id: Q7CQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

99287:STM4377
gene id: 99287:STM4377
uniprot id: Q8ZK94
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

99287:STM1140
gene id: 99287:STM1140
uniprot id: P0A202
names: Function
messages: May be involved in the biogenesis of curli organelles.

99287:STM0392
gene id: 99287:STM0392
uniprot id: P65973
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

99287:STM4048
gene id: 99287:STM4048
uniprot id: P0A2S9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Activates expression of the rhaBAD and rhaT operons.
messages: Binds DNA as a dimer.
messages: Cytoplasm

99287:STM3877
gene id: 99287:STM3877
uniprot id: Q8ZKW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm
messages: Homodimer.

99287:STM4301
gene id: 99287:STM4301
uniprot id: Q8ZKE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

99287:STM3635
gene id: 99287:STM3635
uniprot id: P43666
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoethanolamine transferase family. EptB subfamily.
messages: Catalyzes the addition of a phosphoethanolamine (pEtN) moiety to the outer 3-deoxy-D-manno-octulosonic acid (Kdo) residue of a Kdo(2)-lipid A. Phosphatidylethanolamines with one unsaturated acyl group functions as pEtN donors and the reaction releases diacylglycerol.
messages: Cell inner membrane

99287:STM0160
gene id: 99287:STM0160
uniprot id: Q8ZRS6
names: Similarity
messages: Belongs to the UPF0231 family.

99287:STM4511
gene id: 99287:STM4511
uniprot id: Q7CP75
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM3288
gene id: 99287:STM3288
uniprot id: P67218
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

99287:STM2792
gene id: 99287:STM2792
uniprot id: Q8ZMM1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

99287:STM0806
gene id: 99287:STM0806
uniprot id: P65398
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis (By similarity).

99287:STM3102
gene id: 99287:STM3102
uniprot id: Q8ZM46
names: Similarity
messages: Belongs to the UPF0235 family.

99287:STM0226
gene id: 99287:STM0226
uniprot id: P0A1X4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-(hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.
messages: The SS-C mutant is antibiotic supersensitive; its outer membrane permeability barrier against hydrophobic antibiotics is severely deficient.
messages: Was originally thought to be involved in transcription.

99287:STM0023
gene id: 99287:STM0023
uniprot id: Q8ZS06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

99287:STM1340
gene id: 99287:STM1340
uniprot id: Q8ZPS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).

99287:STM2907
gene id: 99287:STM2907
uniprot id: Q8ZMH3
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Can hydrolyze phosphorylated Ser-, Thr- or Tyr-substrates in vitro. The natural substrate is unknown.
messages: Inhibited by cadmium, copper, zinc when added activity but with less efficiency.
messages: Neither magnesium nor calcium stimulates activity.

99287:STM3371
gene id: 99287:STM3371
uniprot id: P58630
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

99287:STM3922
gene id: 99287:STM3922
uniprot id: Q9L6R3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

99287:STM0387
gene id: 99287:STM0387
uniprot id: P67334
names: Similarity
messages: Belongs to the UPF0178 family.

99287:STM1489
gene id: 99287:STM1489
uniprot id: Q8ZPK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.

99287:STM0874
gene id: 99287:STM0874
uniprot id: Q9Z5Z2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the flavin oxidoreductase frp family.
messages: Binds 1 FMN per monomer.
messages: Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.
messages: Homodimer.

99287:STM0619
gene id: 99287:STM0619
uniprot id: Q8ZR14
names: Similarity
messages: Belongs to the CitG/MdcB family.

99287:STM2100
gene id: 99287:STM2100
uniprot id: P26388
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

99287:STM1830
gene id: 99287:STM1830
uniprot id: Q8ZP03
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.

99287:STM2574
gene id: 99287:STM2574
uniprot id: Q8ZN22
names: Subcellular Location Annotation
messages: Membrane

99287:STM0056
gene id: 99287:STM0056
uniprot id: P58651
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.

99287:STM3420
gene id: 99287:STM3420
uniprot id: Q8ZLM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

99287:STM2808
gene id: 99287:STM2808
uniprot id: P17424
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2F contains the tyrosyl radical required for catalysis.
messages: Tetramer of two alpha and two beta subunits.

99287:STM1886
gene id: 99287:STM1886
uniprot id: Q8ZNW2
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM4126
gene id: 99287:STM4126
uniprot id: P66008
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
messages: Cytoplasm
messages: Homooligomer; probable homooctamer.

99287:STM0079
gene id: 99287:STM0079
uniprot id: Q8ZRW7
names: Subcellular Location Annotation
messages: Membrane

99287:STM0709
gene id: 99287:STM0709
uniprot id: P25078
names: Cofactor
names: Function
names: Sequence Caution
names: Similarity
names: Subunit
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) non-covalently per subunit.
messages: Binds 1 FAD per subunit.
messages: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.
messages: Monomer.
messages: Submitted sequence seems to have every 20th amino acid deleted.

99287:STM4055
gene id: 99287:STM4055
uniprot id: P43019
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

99287:STM0370
gene id: 99287:STM0370
uniprot id: P74840
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PrpD family.
messages: Cells lacking this gene accumulate 2-methylcitrate during growth on propionate.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate. It is also able to catalyze the dehydration of citrate at a lower rate, and the hydration of cis-aconitate. It has no aconitase-like activity and is unable to catalyze the hydration of 2-methyl-cis-aconitate.
messages: Monomer.

99287:STM3999
gene id: 99287:STM3999
uniprot id: Q9F173
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template.
messages: Single-chain monomer with multiple functions.

99287:STM3780
gene id: 99287:STM3780
uniprot id: Q8ZL21
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

99287:STM0700
gene id: 99287:STM0700
uniprot id: Q8ZQW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity.
messages: Cell inner membrane
messages: Membrane

99287:STM3082
gene id: 99287:STM3082
uniprot id: Q8ZM59
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

99287:STM3187
gene id: 99287:STM3187
uniprot id: Q7CPS1
names: Similarity
messages: Belongs to the UPF0441 family.

99287:STM1354
gene id: 99287:STM1354
uniprot id: Q8ZPR8
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

99287:STM2669
gene id: 99287:STM2669
uniprot id: Q7CPZ8
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM1669
gene id: 99287:STM1669
uniprot id: Q8ZP78
names: Similarity
messages: Belongs to the intimin/invasin family.

99287:STM1110
gene id: 99287:STM1110
uniprot id: Q9F0N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IraM/RssC family.
messages: Cytoplasm
messages: Involved in the stabilization of the sigma stress factor RpoS.

99287:STM1141
gene id: 99287:STM1141
uniprot id: P0A200
names: Function
messages: May be involved in the biogenesis of curli organelles.

99287:STM1419
gene id: 99287:STM1419
uniprot id: P74890
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane

99287:STM3903
gene id: 99287:STM3903
uniprot id: P0A1A5
names: Function
names: Similarity
names: Subunit
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Homohexamer.

99287:STM3741
gene id: 99287:STM3741
uniprot id: P0A803
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription (By similarity).

99287:STM3874
gene id: 99287:STM3874
uniprot id: Q8ZKW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

99287:STM3476
gene id: 99287:STM3476
uniprot id: P25926
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Catalyzes nitrite uptake and nitrite export across the cytoplasmic membrane.
messages: Cell inner membrane

99287:STM2803
gene id: 99287:STM2803
uniprot id: Q8ZML3
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

99287:STM1791
gene id: 99287:STM1791
uniprot id: Q7CQE6
names: Similarity
messages: Belongs to the HupH/HyaF family.

99287:STM0024
gene id: 99287:STM0024
uniprot id: Q8ZS05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM3000
gene id: 99287:STM3000
uniprot id: Q8ZMB0
names: Subcellular Location Annotation
messages: Membrane

99287:STM4363
gene id: 99287:STM4363
uniprot id: Q8ZKA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

99287:STM1952
gene id: 99287:STM1952
uniprot id: Q7CQB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

99287:STM3536
gene id: 99287:STM3536
uniprot id: P05415
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by fructose-1,6-bisphosphate (F16BP) and inhibited by AMP.
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

99287:STM2429
gene id: 99287:STM2429
uniprot id: P12673
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CysZ family.
messages: Cell inner membrane
messages: High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway.
messages: Possibly involved in sulfate transport.

99287:STM0625
gene id: 99287:STM0625
uniprot id: Q8ZR09
names: Subcellular Location Annotation
messages: Membrane

99287:STM3344
gene id: 99287:STM3344
uniprot id: P66643
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Binds ObgE/YhbZ (AC Q8ZLS5).

99287:STM2900
gene id: 99287:STM2900
uniprot id: P0CL43
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the InvH family.
messages: Cell outer membrane
messages: Involved in the synthesis of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:9680224, PubMed:9786184). Pilot protein that is required for the proper localization of the secretin InvG/SctC in the outer membrane (PubMed:9680224, PubMed:9786184). Required for the secretion of the Sip virulence factors (PubMed:9680224, PubMed:23159244).
messages: Mutant shows decreased levels of InvG/SctC (PubMed:9786184). Deletion of the gene reduces the invasion efficiency of the bacterium to 70-80% as compared to wild-type in vitro (PubMed:23159244). SctG/invH-ssaV double mutant shows reduced secretion of Sip effector proteins (SipA, SipB, SipC and SipD) (PubMed:23159244).

99287:STM2255
gene id: 99287:STM2255
uniprot id: Q8ZNH9
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.
messages: Membrane

99287:STM4576
gene id: 99287:STM4576
uniprot id: Q8ZJV1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
messages: Cytoplasm
messages: In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
messages: Monomer.

99287:STM3909
gene id: 99287:STM3909
uniprot id: P05989
names: Cofactor
names: Function
names: Induction
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: In the presence of acetohydroxybutyrate and acetolactate.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

99287:STM1449
gene id: 99287:STM1449
uniprot id: Q7CQK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

99287:STM0112
gene id: 99287:STM0112
uniprot id: P37412
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited by p-hydroxymercuribenzoate and N-ethylmaleimide, but not by iodoacetate or iodoacetamide.

99287:STM0489
gene id: 99287:STM0489
uniprot id: P37408
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm
messages: Monomer.

99287:STM0210
gene id: 99287:STM0210
uniprot id: Q8ZRP6
names: Similarity
messages: Belongs to the CdaR family.

99287:STM1290
gene id: 99287:STM1290
uniprot id: P0A1P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
messages: Cytoplasm
messages: Homotetramer.

99287:STM1178
gene id: 99287:STM1178
uniprot id: P16323
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

99287:STM2970
gene id: 99287:STM2970
uniprot id: Q8ZMD1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM4246
gene id: 99287:STM4246
uniprot id: P0A1Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. DnaB subfamily.
messages: Homohexamer.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

99287:STM1373
gene id: 99287:STM1373
uniprot id: Q7CQN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo.
messages: Cytoplasm
messages: Homodimer. Interacts with SufE and the SufBCD complex composed of SufB, SufC and SufD. The interaction with SufE is required to mediate the direct transfer of the sulfur atom from the S-sulfanylcysteine.

99287:STM2295
gene id: 99287:STM2295
uniprot id: Q8ZNF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudI subfamily.
messages: Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).
messages: Monomer.

99287:STM3431
gene id: 99287:STM3431
uniprot id: P66451
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

99287:STM2887
gene id: 99287:STM2887
uniprot id: P40702
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell inner membrane
messages: Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.

99287:STM2461
gene id: 99287:STM2461
uniprot id: P41795
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).
messages: Probably acts on the acetaldehyde produced by the degradation of ethanolamine, producing ethanol.
messages: Unable to grow with ethanolamine (EA) as sole carbon source. Slightly attenuated in a mouse model of infection (PubMed:7868611). Not required for aerobic growth on EA supplemented with cobalamin (vitamin B12). A double eutJ-eutG deletion is not required for growth on EA supplemented with vitamin B12 (PubMed:10464203). A non-polar deletion mutant grows on EA at pH 5.5 to pH 7.0 but not at pH 8.0 or pH 8.5, releases increased amounts of acetaldehyde on EA plus vitamin B12. Preventing acetaldehyde vapor loss allow growth up to pH 8.5 (PubMed:16585748).

99287:STM4250
gene id: 99287:STM4250
uniprot id: P0A2L1
names: Similarity
messages: Belongs to the UPF0047 family.

99287:STM1251
gene id: 99287:STM1251
uniprot id: Q8ZPY6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

99287:STM0440
gene id: 99287:STM0440
uniprot id: Q7CR28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase bacterial subunit 4 family.
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

99287:STM0261
gene id: 99287:STM0261
uniprot id: Q8ZRM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 metal ions per subunit; upon overexpression in E.coli the enzyme purifies with various amounts of iron, zinc and manganese. The endogenous metal is unknown.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

99287:STM0104
gene id: 99287:STM0104
uniprot id: P03022
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose.

99287:STM3544
gene id: 99287:STM3544
uniprot id: Q7CPK2
names: Similarity
messages: Belongs to the pirin family.

99287:STM1431
gene id: 99287:STM1431
uniprot id: P0A2F4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Fe cation per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

99287:STM4577
gene id: 99287:STM4577
uniprot id: Q8ZJV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Smp family.
messages: Cell membrane

99287:STM1828
gene id: 99287:STM1828
uniprot id: Q8ZP05
names: Similarity
messages: Belongs to the UPF0053 family.

99287:STM3815
gene id: 99287:STM3815
uniprot id: Q8XG35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell inner membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

99287:STM2643
gene id: 99287:STM2643
uniprot id: Q8ZMX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. SrmB subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity.
messages: Interacts with the 50S ribosomal subunit.

99287:STM0795
gene id: 99287:STM0795
uniprot id: Q8ZQQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

99287:STM0121
gene id: 99287:STM0121
uniprot id: Q7CR84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

99287:STM2861
gene id: 99287:STM2861
uniprot id: Q7CPX8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

99287:STM3402
gene id: 99287:STM3402
uniprot id: Q8ZLN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

99287:STM2481
gene id: 99287:STM2481
uniprot id: Q8ZN77
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

99287:STM2415
gene id: 99287:STM2415
uniprot id: P0A2K3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

99287:STM2262
gene id: 99287:STM2262
uniprot id: Q8ZNH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I11 (ecotin) family.
messages: General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.
messages: Homodimer.
messages: Periplasm

99287:STM3281
gene id: 99287:STM3281
uniprot id: Q7CPQ1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer.
messages: May be involved in cell division. May play a role in bacterial septation or regulation of cell wall degradation during cell division (By similarity).

99287:STM2974
gene id: 99287:STM2974
uniprot id: Q8ZMC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldolase class II family. AraD/FucA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.

99287:STM2645
gene id: 99287:STM2645
uniprot id: Q8ZMX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rht family.
messages: Cell inner membrane
messages: Exporter of O-acetylserine (OAS) and cysteine.

99287:STM1227
gene id: 99287:STM1227
uniprot id: P26311
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides. Hydrolyzes tripeptides containing N-terminal methionine, leucine, or phenylalanine. Displays little or no activity against dipeptides, N-blocked or C-blocked tripeptides, and tetrapeptides.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited by EDTA.

99287:STM0007
gene id: 99287:STM0007
uniprot id: P66955
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

99287:STM3740
gene id: 99287:STM3740
uniprot id: Q9X6M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

99287:STM3455
gene id: 99287:STM3455
uniprot id: Q8ZLL4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

99287:STM3485
gene id: 99287:STM3485
uniprot id: Q8ZLK3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DamX family.
messages: Cell inner membrane
messages: Non-essential cell division protein.
messages: The SPOR domain binds septal peptidoglycans and is required to target DamX to the septal ring.

99287:STM3685
gene id: 99287:STM3685
uniprot id: Q7CPI1
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Membrane

99287:STM2756
gene id: 99287:STM2756
uniprot id: Q8ZMP8
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

99287:STM0338
gene id: 99287:STM0338
uniprot id: Q8ZRI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

99287:STM0049
gene id: 99287:STM0049
uniprot id: P58679
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
messages: Homodimer.

99287:STM3579
gene id: 99287:STM3579
uniprot id: Q7CPJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

99287:STM0981
gene id: 99287:STM0981
uniprot id: Q7CQT9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

99287:STM3145
gene id: 99287:STM3145
uniprot id: Q8ZM18
names: Similarity
messages: Belongs to the HupJ family.

99287:STM2883
gene id: 99287:STM2883
uniprot id: Q56026
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the invasin protein D family.
messages: Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC.
messages: Secreted
messages: The N-terminal domain is an intra-molecular chaperone that prevents premature oligomerization of the residues on the coiled-coil region that are involved in interactions with the needle and/or itself. The residues in the C-terminal domain probably form oligomeric structures at the tip of the needle that are responsible for the regulation of secretion of other effectors (By similarity).
messages: Transcriptionally regulated by SicA and InvF. Also regulated by InvE.

99287:STM3568
gene id: 99287:STM3568
uniprot id: Q7CPJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

99287:STM0125
gene id: 99287:STM0125
uniprot id: Q8ZRU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

99287:STM2522
gene id: 99287:STM2522
uniprot id: O52765
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

99287:STM1217
gene id: 99287:STM1217
uniprot id: Q7CQQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

99287:STM0960
gene id: 99287:STM0960
uniprot id: Q8ZQD5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Cell inner membrane
messages: Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
messages: Homohexamer. Forms a ring that surrounds DNA (By similarity).

99287:STM0641
gene id: 99287:STM0641
uniprot id: P67520
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

99287:STM3630
gene id: 99287:STM3630
uniprot id: Q8ZLA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

99287:STM1987
gene id: 99287:STM1987
uniprot id: Q8ZNT5
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production (By similarity).
messages: Cell inner membrane
messages: Homodimer.

99287:STM1499
gene id: 99287:STM1499
uniprot id: Q8ZPJ6
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

99287:STM1216
gene id: 99287:STM1216
uniprot id: Q8ZQ01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

99287:STM3937
gene id: 99287:STM3937
uniprot id: Q9L6Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
messages: Monomer.

99287:STM1790
gene id: 99287:STM1790
uniprot id: Q8ZP25
names: Similarity
messages: Belongs to the HupG/HyaE family.

99287:STM1083
gene id: 99287:STM1083
uniprot id: Q7CQS9
names: Similarity
messages: Belongs to the acylphosphatase family.

99287:STM0482
gene id: 99287:STM0482
uniprot id: Q7CR13
names: Subcellular Location Annotation
messages: Cell inner membrane

99287:STM4556
gene id: 99287:STM4556
uniprot id: Q8ZJW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RsmC family.
messages: Cytoplasm
messages: Monomer.
messages: Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.

99287:STM1356
gene id: 99287:STM1356
uniprot id: Q8ZPR6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

99287:STM0234
gene id: 99287:STM0234
uniprot id: Q8ZRN7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

99287:STM0300
gene id: 99287:STM0300
uniprot id: Q8ZRK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

99287:STM0545
gene id: 99287:STM0545
uniprot id: P37923
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm
messages: Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH.

99287:STM3013
gene id: 99287:STM3013
uniprot id: Q8ZMA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

99287:STM2495
gene id: 99287:STM2495
uniprot id: Q8ZN68
names: Similarity
messages: Belongs to the ArsC family.

99287:STM3473
gene id: 99287:STM3473
uniprot id: Q8ZLK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TsgA family.
messages: Cell inner membrane

99287:STM2409
gene id: 99287:STM2409
uniprot id: Q8ZNA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

99287:STM1527
gene id: 99287:STM1527
uniprot id: Q8ZPI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family.
messages: Cell membrane

99287:STM1855
gene id: 99287:STM1855
uniprot id: Q7CQD4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Activator for CDC42 by directly engaging this Rho GTPase and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells. Also activates NF-kB, p38 and ERK kinases, which are known to be involved in the induction of IL-8 expression. Chaperone InvB is required for secretion, translocation and stabilization of intracellular levels of sopE2.
messages: Belongs to the GEF (guanine exchange factor) SopE family.
messages: Secreted
messages: SopE2 is highly conserved among Salmonella isolates of the SARA collection.

99287:STM1537
gene id: 99287:STM1537
uniprot id: Q8ZPH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

99287:STM2137
gene id: 99287:STM2137
uniprot id: Q8ZNP4
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adopts a GT-A fold and acts as an inverting enzyme that converts the alpha-configuration in the UDP-N-acetyl-alpha-D-glucosamine donor to the beta configuration in the N-linked (GlcNAc) arginine product.
messages: Belongs to the glycosyltransferase NleB family.
messages: Host Golgi apparatus
messages: Protein-arginine N-acetylglucosaminyltransferase activity is inhibited by 100066N compound (flavone analog) and 102644N compound (a substituted isoxazole).
messages: Protein-arginine N-acetylglucosaminyltransferase effector that catalyzes the transfer of a single N-acetylglucosamine (GlcNAc) to a conserved arginine residue in the death domain of host proteins such as FADD: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions (PubMed:28522607). Also acts on host proteins without a death domain: catalyzes arginine GlcNAcylation of host small Rab1 GTPase, thereby preventing GTPase activity and leading to impaired host vesicular protein transport (By similarity). In contrast to Ssek1, not able to disrupt TNF signaling in infected cells (PubMed:28522607).
messages: Secreted

99287:STM4272
gene id: 99287:STM4272
uniprot id: Q8ZKF9
names: Subcellular Location Annotation
messages: Membrane

99287:STM4266
gene id: 99287:STM4266
uniprot id: P0A2R0
names: Function
names: Subunit
messages: Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress (By similarity).
messages: Homodimer.

99287:STM0501
gene id: 99287:STM0501
uniprot id: Q8ZR94
names: Similarity
messages: Belongs to the band 7/mec-2 family.

99287:STM4398
gene id: 99287:STM4398
uniprot id: Q8ZK77
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM2483
gene id: 99287:STM2483
uniprot id: Q8ZN75
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 divalent cations per subunit, one with high affinity and the other with lower affinity. Zn(2+) and/or Co(2+) ions are used for desuccinylase activity. The form of DapE active as a peptidase contains Zn(2+) in the high-affinity site and Mn(2+) in the low-affinity site.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp-Cys.
messages: Homodimer.
messages: Mn(2+)-activated peptidase is inhibited by Mn(2+) at concentration above 1 mM and by increasing concnentrations of Co(2+). There is a competitive inhibitor effect between the substrates. Hydrolysis of Asp-Leu by Mn(2+)-activated DapE is inhibited by SDAP, and hydrolysis of SDAP by Co(2+)-activated DapE is inhibited by Asp-Ser.
messages: Zn(+2) is usually found in the tight binding site, but the nature of the second cation in the low affinity binding site is different according the activity.

99287:STM2931
gene id: 99287:STM2931
uniprot id: P64162
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

99287:STM1798
gene id: 99287:STM1798
uniprot id: Q8ZP19
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Overexpression of this gene decreases swimming and swarming motility; those cells that are motile turn predominantly counterclockwise. The D-118 mutant is still able to bind FliM but no longer affects motility upon overexpression. Binds 1 c-di-GMP dimer per subunit.
messages: Bacterial flagellum basal body
messages: Belongs to the YcgR family.
messages: Monomer. Interacts with the flagellar basal bodies (By similarity).
messages: No visible motility phenotype. Disruption of this gene suppresses the reduced motility of a yhjH disruption, thus the double knockout is motile. Overexpression of this gene in a yhjH disruption has the converse effect, i.e. it reduces motility further.
messages: The N-terminal domain is involved in FliG binding, the C-terminal domain is involved in FliM binding.

99287:STM0633
gene id: 99287:STM0633
uniprot id: Q8ZR04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

99287:STM2660
gene id: 99287:STM2660
uniprot id: Q7CQ01
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent (By similarity).
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Required for colonization of the gastrointestinal tract, probably due to protection from a combination of stress factors.
messages: The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity).

99287:STM3646
gene id: 99287:STM3646
uniprot id: Q8ZLA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
messages: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
messages: Cytoplasm
messages: Homodimer.

99287:STM1190
gene id: 99287:STM1190
uniprot id: P0A1T2
names: Function
names: Induction
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Part of the yceD-rpmF operon, which may continue into downstream genes.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

99287:STM0602
gene id: 99287:STM0602
uniprot id: Q8ZR27
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

99287:STM1376
gene id: 99287:STM1376
uniprot id: Q8ZPP9
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Lpp family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Plays an important role in virulence (PubMed:15213144). A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane (By similarity).
messages: The integrity of the cell envelope in a lpp null mutant (double-knockout) is not affected.
messages: This gene is probably poorly expressed.
messages: cell wall

99287:STM3862
gene id: 99287:STM3862
uniprot id: Q8ZKX0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

99287:PSLT018
gene id: 99287:PSLT018
uniprot id: H9L498
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM4369
gene id: 99287:STM4369
uniprot id: Q8ZKA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

99287:STM0946
gene id: 99287:STM0946
uniprot id: P59696
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the IS200/IS605 insertion sequence (IS) element family.
messages: Belongs to the transposase 17 family.
messages: Homodimer.
messages: Transposase responsible for transposition of the IS200 insertion sequence (IS) element. Transposition occurs in 2 main steps, excision from the donor DNA 'top strand' into a single strand circle and its subsequent reinsertion into the DNA target. This increases the copy number of the IS.

99287:STM4523
gene id: 99287:STM4523
uniprot id: Q8ZJY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SymE family.
messages: Cytoplasm
messages: Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease Lon.

99287:STM0218
gene id: 99287:STM0218
uniprot id: P65933
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Probably inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.

99287:STM0624
gene id: 99287:STM0624
uniprot id: Q8ZR10
names: Function
messages: Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

99287:STM0693
gene id: 99287:STM0693
uniprot id: Q7CQY3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

99287:STM3044
gene id: 99287:STM3044
uniprot id: P0A2P6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.
messages: FtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerD specifically exchanges the bottom DNA strands (By similarity).

99287:STM2167
gene id: 99287:STM2167
uniprot id: Q8ZNM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinone-dependent D-lactate dehydrogenase family.
messages: Catalyzes the oxidation of D-lactate to pyruvate.
messages: Cell inner membrane

99287:STM3912
gene id: 99287:STM3912
uniprot id: Q9L6S1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. UvrD subfamily.
messages: Homodimer.
messages: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

99287:STM4085
gene id: 99287:STM4085
uniprot id: Q8ZKP4
names: Similarity
messages: Belongs to the FBPase class 2 family.

99287:STM2214
gene id: 99287:STM2214
uniprot id: Q7CQ75
names: Similarity
messages: Belongs to the peptidase C40 family.

99287:STM4228
gene id: 99287:STM4228
uniprot id: P26467
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE).

99287:STM2926
gene id: 99287:STM2926
uniprot id: Q8ZMF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

99287:STM2399
gene id: 99287:STM2399
uniprot id: P12681
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: By extracellular phosphoglycerate.
messages: Cell inner membrane
messages: The phosphoglycerate transporter protein is a part of the PGT transport system. It is the membrane bound transporter for phosphoglycerate into salmonella.

99287:STM0350
gene id: 99287:STM0350
uniprot id: Q8ZRH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane
messages: Membrane

99287:STM1775
gene id: 99287:STM1775
uniprot id: P40816
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

99287:STM4329
gene id: 99287:STM4329
uniprot id: P0A1D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

99287:STM1708
gene id: 99287:STM1708
uniprot id: Q7CQG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

99287:STM3821
gene id: 99287:STM3821
uniprot id: Q8ZKZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TorD/DmsD family. TorD subfamily.
messages: Cytoplasm
messages: Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.

99287:STM0427
gene id: 99287:STM0427
uniprot id: P96064
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Induced when inorganic phosphate is limiting; this is controlled by PhoB.
messages: Maps to a phosphate-starvation-inducible locus previously known as PsiC.
messages: Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import. Probably responsible for the translocation of the substrate across the membrane.

99287:STM1953
gene id: 99287:STM1953
uniprot id: Q8ZNT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
messages: Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.
messages: Homodimer.

99287:STM2494
gene id: 99287:STM2494
uniprot id: P66950
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48 family. BepA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
messages: Periplasm

99287:STM1198
gene id: 99287:STM1198
uniprot id: Q7CQR1
names: Similarity
names: Subunit
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

99287:STM0246
gene id: 99287:STM0246
uniprot id: Q8ZRN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity).

99287:STM2202
gene id: 99287:STM2202
uniprot id: Q8ZNK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Cell inner membrane

99287:STM3776
gene id: 99287:STM3776
uniprot id: Q7CPG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily.
messages: Cell inner membrane
messages: Involved in the efflux of purine ribonucleosides, such as inosine and guanosine.

99287:STM3680
gene id: 99287:STM3680
uniprot id: Q8ZL72
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

99287:STM0191
gene id: 99287:STM0191
uniprot id: Q8ZRQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

99287:STM0645
gene id: 99287:STM0645
uniprot id: Q8ZQZ8
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

99287:STM3840
gene id: 99287:STM3840
uniprot id: P66686
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

99287:STM3661
gene id: 99287:STM3661
uniprot id: Q8ZL90
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

99287:STM1317
gene id: 99287:STM1317
uniprot id: Q8ZPU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YdjC deacetylase family. ChbG subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF.

99287:STM3023
gene id: 99287:STM3023
uniprot id: Q7CPV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FrmR/RcnR family.
messages: Cytoplasm
messages: Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter (By similarity).

99287:STM3121
gene id: 99287:STM3121
uniprot id: H9L457
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM0111
gene id: 99287:STM0111
uniprot id: P15717
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

99287:STM1257
gene id: 99287:STM1257
uniprot id: Q7CQQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

99287:STM2800
gene id: 99287:STM2800
uniprot id: Q8ZML6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AlaE exporter family.
messages: Cell inner membrane
messages: Exports L-alanine.

99287:STM2464
gene id: 99287:STM2464
uniprot id: P41792
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double eutM-eutN strain grows as well as wild-type on ethanolamine (EA) and cyanocobalamin, but a quadruple eutL-eutK-eutM-eutN strain does not grow (PubMed:16291677). A non-polar deletion mutant grows on EA at pH 5.5 to pH 7.0 but not at pH 8.0 or pH 8.5, releases increased amounts of acetaldehyde on EA plus vitamin B12. Preventing acetaldehyde vapor loss allow growth up to pH 8.5 (PubMed:16585748).
messages: Artificial BMCs can be made in E.coli by expressing eutK, eutL, eutM, eutN, eutS (eutSMNLK) or eutS alone. Cargo proteins can be targeted to them and beta-galactosidase (lacZ) was active within the BMC, showing the BMC allows passage of substrate into the interior. This can lead to the development of tailored BMCs for specific metabolic reactions (PubMed:22428024). The addition of eutQ to the eutSMNLK construct results in biogenesis of multiple BMCs (PubMed:27063436).
messages: Bacterial microcompartment
messages: Belongs to the CcmL/EutN family.
messages: Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Homopentamer with a small central pore.
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).
messages: Probably forms vertices in the bacterial microcompartment (BMC) shell dedicated to ethanolamine degradation. Expression of eutK, eutL, eutM, eutN, eutS (eutSMNLK) in E.coli leads to formation of a single BMC (PubMed:22428024, PubMed:27063436). Coexpression of eutQ with eutSMNLK permits E.coli to make cells with more than one mobile BMC, as is usual in vivo (PubMed:27063436). It may be involved in transporting positively charged molecules into and out of the BMC (By similarity).
messages: The ethanolamine (EA) catabolic bacterial microcompartment (BMC) probably concentrates low levels of ethanolamine catabolic enzymes, concentrates volatile reaction intermediates, keeps the level of toxic acetaldehyde low, generates enough acetyl-CoA to support cell growth, and maintains a pool of free coenzyme A (CoA) and NAD.
messages: The need for a bacterial microcompartment in EA metabolism can be bypassed by increasing the levels of EAL and an acetaldehyde dehydrogenase (not necessarily EutE).

99287:STM4088
gene id: 99287:STM4088
uniprot id: Q8ZKP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapB family.
messages: Cytoplasm
messages: Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ.
messages: Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.

99287:STM1470
gene id: 99287:STM1470
uniprot id: O52714
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tus family.
messages: Cytoplasm
messages: Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence.

99287:STM3508
gene id: 99287:STM3508
uniprot id: Q8ZLJ0
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

99287:STM4595
gene id: 99287:STM4595
uniprot id: Q8ZJT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM0365
gene id: 99287:STM0365
uniprot id: Q8ZRF9
names: Similarity
messages: Belongs to the Rht family.

99287:STM2654
gene id: 99287:STM2654
uniprot id: Q8ZMX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
messages: Cell inner membrane
messages: Membrane

99287:STM3560
gene id: 99287:STM3560
uniprot id: P0A191
names: Caution
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily.
messages: Called LivG in S.typhimurium, but we renamed it to LivF for the sake of consistency with the E.coli protein.
messages: Component of the high-affinity branched-chain amino acid transport system.

99287:STM0358
gene id: 99287:STM0358
uniprot id: P40815
names: Function
names: Similarity
names: Subunit
messages: A type III restriction enzyme that recognizes 2 inversely oriented double-stranded sequences 5'-CAGAG-3' and cleaves DNA 25-27 base pairs downstream. After binding to one recognition site undergoes random one-dimensional diffusion along DNA until it collides with a stationary enzyme bound to the second DNA site, which is when DNA cleavage occurs. DNA restriction requires both the Res and Mod subunits.
messages: Belongs to the type III restriction-modification system Res protein family.
messages: Contains two different subunits: Res and Mod.

99287:STM0957
gene id: 99287:STM0957
uniprot id: Q8ZQD6
names: Subcellular Location Annotation
messages: Membrane

99287:STM4075
gene id: 99287:STM4075
uniprot id: Q8ZKQ3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor.
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable).
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

99287:STM0791
gene id: 99287:STM0791
uniprot id: Q8ZQQ9
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

99287:STM0770
gene id: 99287:STM0770
uniprot id: Q8ZQS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

99287:STM3658
gene id: 99287:STM3658
uniprot id: Q8ZL93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyltransferase 3 family.
messages: Cell inner membrane
messages: Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units.

99287:STM4258
gene id: 99287:STM4258
uniprot id: Q8ZKG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

99287:STM1080
gene id: 99287:STM1080
uniprot id: Q8ZQ64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmI family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.

99287:STM0313
gene id: 99287:STM0313
uniprot id: P63989
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

99287:STM2558
gene id: 99287:STM2558
uniprot id: Q8ZN34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Membrane

99287:STM2154
gene id: 99287:STM2154
uniprot id: Q8ZNN5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins (PubMed:18616280, PubMed:19001370). Can hydrolyze ATP (PubMed:12486045, PubMed:19001370). Both activities are required for function in vivo, but the ability to hydrolyze ATP is not necessary for Fe-S cluster transfer (PubMed:19001370).
messages: Homodimer. Holo-ApbC forms a mixture of homodimers and homotetramers.
messages: Mutants are impaired in Fe-S cluster metabolism. They are conditional thiamine auxotrophs and have lower aconitase and succinate dehydrogenase activities.

99287:STM2261
gene id: 99287:STM2261
uniprot id: Q8ZNH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapF family.
messages: Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

99287:STM2938
gene id: 99287:STM2938
uniprot id: Q8ZMF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

99287:STM3247
gene id: 99287:STM3247
uniprot id: Q8ZLV9
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

99287:STM1145
gene id: 99287:STM1145
uniprot id: P0A1Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgC/AgfC family.
messages: Periplasm
messages: Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity).

99287:STM1681
gene id: 99287:STM1681
uniprot id: Q8ZP66
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

99287:STM1978
gene id: 99287:STM1978
uniprot id: P0A1L1
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliO/MopB family.
messages: Cell membrane

99287:STM0198
gene id: 99287:STM0198
uniprot id: H9L409
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM1155
gene id: 99287:STM1155
uniprot id: Q8ZQ24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family.
messages: Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to a Kdo(2)-lipid IV(A) to form a Kdo(2)-(acyl)-lipid IV(A).
messages: Cell inner membrane

99287:STM0856
gene id: 99287:STM0856
uniprot id: Q8ZQL8
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

99287:STM3193
gene id: 99287:STM3193
uniprot id: Q8ZLZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Belongs to the thioredoxin family. DsbL subfamily.
messages: Interacts with DsbI.
messages: Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT.
messages: Periplasm

99287:STM1827
gene id: 99287:STM1827
uniprot id: Q8ZP06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.
messages: Membrane

99287:STM4099
gene id: 99287:STM4099
uniprot id: P06203
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MetJ family.
messages: Cytoplasm
messages: Does not bind DNA by a helix-turn-helix motif.
messages: Homodimer.
messages: This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated (By similarity).

99287:STM2045
gene id: 99287:STM2045
uniprot id: H9L478
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Artificial BMCs can be made in E.coli by expressing pduA-pduB/B'-pduT-pduU-pduN-pduJ-pduK (in this order). Enzymes can be targeted to the BMC, and appear to be encapsulated within it.
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the bacterial microcompartments protein family.
messages: Cells lacking this gene are defective in aerobic degradation of propanediol (PubMed:9023178). Most cells lack BMCs, 22% have highly elongated internal structures, 20% have amorphous polar bodies. Grows in an interrupted manner on 1,2-PD and vitamin B12; grows for a while then stops, then restarts as if a toxic compound was accumulating and then decreases (PubMed:21239588). Grows faster under limiting vitamin B12 conditions, forms elongated BMCs (PubMed:24747050). A double pduJ-pduK strain grows in an interrupted manner on 1,2-PD and vitamin B12; grows for a while then stops, then restarts as toxic propionaldehyde accumulates and then decreases (PubMed:18296526). Makes elongated BMCs; this phenotype can be rescued by PduA or PduJ, but PduJ encoded on a plasmid cannot rescue a PduA deletion. When pduJ is cloned in the chromosomal position of pduA it substantially rescues the pduA deletion (PubMed:27561553, PubMed:33227310). Single pduA deletion makes BMCs but a double pduA-pduJ deletion does not (PubMed:33227310).
messages: Homohexamer with a central pore of about 5.7 Angstroms in diameter (PubMed:27561553). Interacts with PduP, which targets PduP to the BMC (PubMed:22927404).
messages: One of the major shell proteins of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. The isolated BMC shell component protein ratio for J:A:B':B:K:T:U is approximately 15:10:7:6:1:1:2 (PubMed:12923081). At least one of PduA or PduJ is required for BMC assembly; it must be encoded as the first gene in the pdu operon (PubMed:33227310, PubMed:27561553). Required for structural integrity of BMCs and to mitigate propionaldehyde toxicity, probably joins facets responsible for BMC closure (PubMed:21239588). Edge residues (particularly Lys-25) are important for function and assembly of the BMC (PubMed:24747050). 80% identical to PduA; although their pore regions appear structurally identical, unlike PduA plays no role in 1,2-PD diffusion into or out of the BMC shell. If pduJ is cloned in the chromosomal position of pduA it is able to complement a pduA deletion; it then has a functional pore as it assumes the transport functions of PduA (PubMed:27561553). Overexpression of this protein leads to aberrant filaments that extend the length of the cell, cross the cleavage furrow and impair division. The filaments form nanotubes with a hollow center (PubMed:33227310). Modeling suggests PduJ is probably the hub for binding multiple enzymes to the interior of the BMC; modeling suggests PduC, PduD, PduG and PduM are targeted to PduJ (Probable).
messages: The 1,2-propanediol (1,2-PD) degradation bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.

99287:STM0846
gene id: 99287:STM0846
uniprot id: Q56066
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

99287:STM4167
gene id: 99287:STM4167
uniprot id: Q9L9I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

99287:STM1085
gene id: 99287:STM1085
uniprot id: Q8ZQ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

99287:STM3842
gene id: 99287:STM3842
uniprot id: Q8ZKY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

99287:STM3927
gene id: 99287:STM3927
uniprot id: Q9L6Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 56 family.
messages: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
messages: Cell inner membrane

99287:PSLT038
gene id: 99287:PSLT038
uniprot id: P0A2M9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphothreonine lyase family.
messages: Secreted
messages: Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized pro-inflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.
messages: Strains lacking this gene are attenuated for systemic virulence in mice.

99287:STM2319
gene id: 99287:STM2319
uniprot id: Q7CQ53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

99287:STM4064
gene id: 99287:STM4064
uniprot id: P26219
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cdh family.
messages: Cell inner membrane
messages: Was originally thought to be a UDP-sugar hydrolase.

99287:STM2538
gene id: 99287:STM2538
uniprot id: Q7CQ13
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

99287:STM4407
gene id: 99287:STM4407
uniprot id: Q7CP89
names: Subcellular Location Annotation
messages: Membrane

99287:STM3655
gene id: 99287:STM3655
uniprot id: Q8ZL96
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

99287:STM2898
gene id: 99287:STM2898
uniprot id: P35672
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial secretin family. T3SS SctC subfamily.
messages: Cell outer membrane
messages: Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:9786184, PubMed:27974800, PubMed:30242280). Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane (PubMed:9786184, PubMed:21385715, PubMed:27974800, PubMed:30242280).
messages: Insertion mutants are hypoinvasive in the HEp-2 cell assay.
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569). This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope (PubMed:21385715, PubMed:23633951, PubMed:27974800, PubMed:30242280). Forms a stable homooligomeric complex (PubMed:9786184, PubMed:21385715, PubMed:23633951, PubMed:27974800, PubMed:30242280). The complex is composed of 15 subunits (PubMed:21385715, PubMed:23633951, PubMed:27974800).

99287:STM2303
gene id: 99287:STM2303
uniprot id: Q8ZNF0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArnF family.
messages: Cell inner membrane
messages: Heterodimer of ArnE and ArnF.
messages: No change observed, indicating that it could be not necessary for the Ara4N addition to lipid A and polymyxin resistance.
messages: Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.

99287:STM4328
gene id: 99287:STM4328
uniprot id: Q8ZKC0
names: Subcellular Location Annotation
messages: Membrane

99287:STM2121
gene id: 99287:STM2121
uniprot id: P63905
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

99287:STM2986
gene id: 99287:STM2986
uniprot id: Q8ZMC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

99287:STM2035
gene id: 99287:STM2035
uniprot id: P29946
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Is able to use other nucleotide triphosphates as substrate, such as GTP or UTP, although less efficiently than ATP.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: Monomer.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

99287:STM0144
gene id: 99287:STM0144
uniprot id: Q7CR79
names: Subcellular Location Annotation
messages: Membrane

99287:STM2160
gene id: 99287:STM2160
uniprot id: P0CL12
names: Function
messages: Transcriptional activator of csgD, which is required for production of the curli (AgF).

99287:STM1397
gene id: 99287:STM1397
uniprot id: O84944
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Binds to SseB and SseD.
messages: Cytoplasm
messages: Expression is regulated by the two-component regulatory system SsrA/SsrB.
messages: Functions as a type III secretion system (T3SS) chaperone, which is required for SseB and SseD accumulation and secretion. May have a direct role in secretion of SseB and SseD, or may facilitate their correct folding, for efficient secretion and function. Required for survival and replication within epithelial cells and macrophages.
messages: Mutant is severely attenuated in virulence.
messages: The N-terminal region is dispensable for binding and stabilizing SseB, but is essential for export of SseB to the surface of the bacterium.

99287:STM3629
gene id: 99287:STM3629
uniprot id: Q7CPI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

99287:STM3700
gene id: 99287:STM3700
uniprot id: P0A1P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

99287:STM0457
gene id: 99287:STM0457
uniprot id: Q8ZRB6
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. Cof family.
messages: Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

99287:STM3022
gene id: 99287:STM3022
uniprot id: Q8ZM95
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM4465
gene id: 99287:STM4465
uniprot id: Q8ZK35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

99287:STM0851
gene id: 99287:STM0851
uniprot id: Q7CQV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).

99287:STM1540
gene id: 99287:STM1540
uniprot id: Q8ZPG8
names: Similarity
messages: Belongs to the peptidase C59 family.

99287:STM3556
gene id: 99287:STM3556
uniprot id: Q8ZLF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

99287:STM3618
gene id: 99287:STM3618
uniprot id: Q93IN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AcsB/BcsB family.
messages: Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP).
messages: Cell inner membrane
messages: Tightly associated with the cellulose synthase catalytic subunit.

99287:STM0648
gene id: 99287:STM0648
uniprot id: Q8ZQZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

99287:STM0973
gene id: 99287:STM0973
uniprot id: Q7CQU1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

99287:STM2269
gene id: 99287:STM2269
uniprot id: Q8ZNH2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RcsD family.
messages: Cell inner membrane
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB.
messages: Interacts with RcsC and RcsB.
messages: Phosphorylated by RcsC.

99287:STM2313
gene id: 99287:STM2313
uniprot id: P60195
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family. RNase BN subfamily.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities.

99287:STM1280
gene id: 99287:STM1280
uniprot id: Q8ZPW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0756 family.
messages: Cell membrane

99287:STM3244
gene id: 99287:STM3244
uniprot id: P11954
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine to yield pyruvate via analogous enamine/imine intermediates.
messages: Each protein molecule can bind up to four molecules of AMP, which act as an allosteric activator to the enzyme. The enzyme is inhibited by alpha-keto acids and other catabolites.
messages: In the native structure, TdcB is in a dimeric form, whereas in the TdcB-AMP complex, it exists in a tetrameric form (dimer of dimers).

99287:STM0372
gene id: 99287:STM0372
uniprot id: Q7CR48
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

99287:STM1415
gene id: 99287:STM1415
uniprot id: P74857
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:24722491). Acts as a molecular motor to provide the energy that is required for the export of proteins (By similarity). Required for type III secretion apparatus (T3SA) formation, secretion of a subset of SPI-2 effectors and virulence (PubMed:24722491, PubMed:25035427). May play a critical role in T3SS substrate recognition, disassembly of the effector/chaperone complex and unfolding of the effector in an ATP-dependent manner prior to secretion (Probable). Releases the effector protein SseB from the T3SS-2 specific chaperone SsaE in an ATP-dependent manner (PubMed:24722491).
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cytoplasm
messages: Deletion mutant cannot secrete the effector proteins SseB, SseC, SseD, SseF, SseG and SseJ (PubMed:24722491, PubMed:25035427). Mutant is also defective for the secretion of the translocon proteins SseC/SctE and SseD/SctB (PubMed:25035427). Mutant shows decreased virulence in the mouse model of systemic infection (PubMed:24722491).
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569). This subunit is part of the cytosolic complex (PubMed:24722491). Forms homohexamers (PubMed:25035427). Forms a complex with SsaK/SctL (stator protein) and SsaQ/SctQ (the major sorting platform component) (PubMed:24722491). Interacts with the T3SS-2 specific chaperones SsaE, SseA, SscA, SscB, and SrcA (PubMed:24722491, PubMed:25035427).

99287:STM4381
gene id: 99287:STM4381
uniprot id: Q7CP93
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Represses ulaG and the ulaABCDEF operon.

99287:STM0153
gene id: 99287:STM0153
uniprot id: Q8ZRT1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 3 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

99287:STM1426
gene id: 99287:STM1426
uniprot id: Q8ZPP1
names: Function
messages: Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.

99287:STM4572
gene id: 99287:STM4572
uniprot id: Q8ZJV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

99287:STM1905
gene id: 99287:STM1905
uniprot id: Q7CQC4
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Deletion mutant shows accumulation of 5-methoxyuridine (mo5U34) and 5-hydroxyuridine (ho5U34) in tRNA.
messages: Homodimer.
messages: Was originally thought to be a transferase that mediates the conversion of mo5U(34) to cmo5U(34) in tRNAs.

99287:STM1215
gene id: 99287:STM1215
uniprot id: Q8ZQ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YkuD family.
messages: Periplasm

99287:STM0550
gene id: 99287:STM0550
uniprot id: P26318
names: Subcellular Location Annotation
messages: Fimbrium

99287:STM1755
gene id: 99287:STM1755
uniprot id: Q8ZP43
names: Similarity
messages: Belongs to the UPF0225 family.

99287:STM1491
gene id: 99287:STM1491
uniprot id: Q8ZPK4
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Deletion of the osmU operon eliminates the residual osmoprotection by glycine betaine in a mutant that is lacking the ProP and the ProU systems. OsmU deletion has no effect on the utilization of glycine betaine as an osmoprotectant when ProP or ProU are functional.
messages: Induced by osmotic stress. Part of the osmU operon, which consists of four genes (osmV, osmW, osmX and osmY).
messages: Part of the OsmU ABC transporter complex, which is involved in the uptake of osmoprotectants such as choline-O-sulfate and glycine betaine. Probably responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (OsmV), two transmembrane proteins (OsmW and OsmY) and a solute-binding protein (OsmX).

99287:STM2321
gene id: 99287:STM2321
uniprot id: Q7CQ51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

99287:STM2959
gene id: 99287:STM2959
uniprot id: Q8ZME0
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

99287:STM4259
gene id: 99287:STM4259
uniprot id: Q8ZKG7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

99287:STM2790
gene id: 99287:STM2790
uniprot id: Q8ZMM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L2HGDH family.
messages: Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
messages: Cell inner membrane

99287:STM2871
gene id: 99287:STM2871
uniprot id: P41786
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YscJ lipoprotein family.
messages: Cell outer membrane
messages: Required for invasion of epithelial cells. Could be involved in protein secretion.

99287:STM4007
gene id: 99287:STM4007
uniprot id: P0A1P6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Binds 2 Mn(2+) ions per subunit.
messages: Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexameric ring.
messages: When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) of GlnE inhibits GlnA by covalent transfer of an adenylyl group from ATP to Tyr-398. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) of GlnE activates GlnA by removing the adenylyl group by phosphorolysis. The fully adenylated enzyme complex is inactive.

99287:STM1776
gene id: 99287:STM1776
uniprot id: P0A287
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

99287:STM2925
gene id: 99287:STM2925
uniprot id: P40827
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activator of the cell wall hydrolase AmiC. Required for septal murein cleavage and daughter cell separation during cell division (By similarity).
messages: Belongs to the E.coli NlpD/Haemophilus LppB family.
messages: Cell inner membrane

99287:STM4016
gene id: 99287:STM4016
uniprot id: Q9L7R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligogalacturonate-specific porin KdgM (TC 1.B.35) family. OmpL subfamily.
messages: Cell outer membrane
messages: Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is unknown (By similarity).

99287:STM0944
gene id: 99287:STM0944
uniprot id: P67649
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

99287:STM1864
gene id: 99287:STM1864
uniprot id: Q8ZNY1
names: Subcellular Location Annotation
messages: Membrane

99287:STM3109
gene id: 99287:STM3109
uniprot id: Q8ZM40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Monomer.

99287:STM1150
gene id: 99287:STM1150
uniprot id: P67557
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OpgD/OpgG family.
messages: Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
messages: Periplasm

99287:STM2018
gene id: 99287:STM2018
uniprot id: Q05599
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.
messages: Homotrimer.

99287:STM4271
gene id: 99287:STM4271
uniprot id: Q7CPA8
names: Subcellular Location Annotation
messages: Membrane

99287:STM3410
gene id: 99287:STM3410
uniprot id: P0A1X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.

99287:STM1539
gene id: 99287:STM1539
uniprot id: Q8ZPG9
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

99287:STM2777
gene id: 99287:STM2777
uniprot id: Q8ZMN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

99287:STM2108
gene id: 99287:STM2108
uniprot id: Q8XGS8
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

99287:STM3277
gene id: 99287:STM3277
uniprot id: Q8ZLT7
names: Similarity
messages: Belongs to the YkuD family.

99287:STM3254
gene id: 99287:STM3254
uniprot id: Q8ZLV4
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

99287:STM3433
gene id: 99287:STM3433
uniprot id: Q7CPL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

99287:STM0606
gene id: 99287:STM0606
uniprot id: Q8ZR23
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM0404
gene id: 99287:STM0404
uniprot id: Q8ZRD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

99287:STM2894
gene id: 99287:STM2894
uniprot id: P0A1B9
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:15060043, PubMed:16208377, PubMed:26170413). Acts as a molecular motor to provide the energy that is required for the export of proteins (Probable). Required for type III secretion apparatus (T3SA) formation, proper protein secretion, host cell invasion and virulence (PubMed:8045880, PubMed:14762212, PubMed:15060043, PubMed:26170413). May play a critical role in T3SS substrate recognition, disassembly of the effector/chaperone complex and unfolding of the effector in an ATP-dependent manner prior to secretion (PubMed:16208377). Releases the effector protein SptP from the chaperone SicP in an ATP-dependent manner (PubMed:16208377).
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Binding of ATP leads to conformational changes of two loops located outside of the catalytic site. These changes could be critical for interaction with the stalk protein InvI/SctO or with chaperone and effector proteins during type III secretion.
messages: Cytoplasm
messages: Deletion of the gene affects the overall stability of the cytoplasmic sorting platform (PubMed:28283062). Disruption mutant is defective in its ability to enter cultured epithelial cells (PubMed:8045880).
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569, PubMed:28283062). This subunit is part of the cytosolic complex (PubMed:15060043, PubMed:31288030, PubMed:28283062). Forms homohexamers (PubMed:15060043, PubMed:28283062). Interacts directly with OrgB/SctL (stator protein) and InvI/SctO (stalk protein) (PubMed:15060043, PubMed:31288030, PubMed:28283062). Forms a complex with SpaO/SctQ and OrgB/SctL (PubMed:31288030). Interacts with the chaperone/effector protein complex SicP-SptP via its C terminus (PubMed:16208377). Interacts with the effector protein SopD (PubMed:20185511).

99287:STM3493
gene id: 99287:STM3493
uniprot id: Q8ZLJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

99287:STM3716
gene id: 99287:STM3716
uniprot id: P26472
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. RfaY/WaaY family.
messages: Catalyzes the phosphorylation of heptose(II) of the outer membrane lipopolysaccharide core.

99287:STM1231
gene id: 99287:STM1231
uniprot id: P0DM78
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: 10,000-fold reduction in virulence in male BALB/c mice (for strain ATCC 14028). Decreased tolerance to acid stress.
messages: Cytoplasm
messages: Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides (PubMed:2544889, PubMed:9573193, PubMed:25972862). Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Essential for transcription of spiC inside macrophages by controlling the expression of the two-component regulatory system SsrB/SpiR (SsrA) and Pir at transcriptional and post-transcriptional levels respectively. Promotes expression of the two-component regulatory system PmrA/PmrB via activation of pmrD gene. Is required to attenuate bacterial growth within fibroblast cells and to enhance bacterial resistance to bile in intestinal cells. Negatively regulates prgH, which is required for invasion of epithelial cells. PhoP uses multiple mechanisms to promote transcription and activates promoters for PAG at low (uM range) Mg(2+) concentrations (Probable). Involved in acid tolerance.
messages: Monomer in the inactive, unphosphorylated state and dimer in the active, phosphorylated state.
messages: PhoP/PhoQ-signaling cascade, which activates virulence membrane proteins (PagC, PagO, PagD, PagK, PgtE and PhoN), is induced by cationic antimicrobial peptides (CAMP) (polymyxin, alpha-helical peptide C18G and sheet peptide protegrin-1) at sublethal concentrations.
messages: Phosphorylated and dephosphorylated by PhoQ.
messages: The phoP/phoQ operon is positively autoregulated by both PhoP and PhoQ in a Mg(2+)-dependent manner. Repressed by RcsB via sigma factor RpoS.

99287:STM2228
gene id: 99287:STM2228
uniprot id: P40709
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: To H.influenzae HI_0842.

99287:PSLT028
gene id: 99287:PSLT028
uniprot id: Q93GR5
names: Similarity
messages: Belongs to the CcdB toxin family.

99287:STM2544
gene id: 99287:STM2544
uniprot id: Q7CQ10
names: Cofactor
names: Function
messages: Binds 1 [2Fe-2S] cluster.
messages: Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.

99287:STM0057
gene id: 99287:STM0057
uniprot id: P0A2F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:citrate (SCF) symporter family.
messages: Cell membrane
messages: Uptake of citrate across the boundary membrane with the concomitant uptake of a sodium ion (symport system).

99287:STM2458
gene id: 99287:STM2458
uniprot id: P19264
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds (Probable). It is spontaneously inactivated by its substrate and reactivated by EutA (By similarity). May play a role in BMC assembly or maintenance (Probable).
messages: Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase activity and to induce the operon. EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: No aerobic growth on ethanolamine (EA) supplemented with cobalamin (vitamin B12) (PubMed:10464203, PubMed:2656649). No phenotype during growth in vitro. Decreased expression of eutR during bacterial growth in vitro. About 10-fold outcompeted by wild-type in mouse intestine at 2 and 4 days following oral infection, but no effect seen during growth in peritoneal exudate macrophages (PubMed:26565973). A non-polar deletion mutant does not grow on EA between pH 5.5 and pH 8.5, stops acetaldehyde release on EA plus vitamin B12 (PubMed:16585748). A deletion allows growth on acetate, suggesting BMC assembly or maintenance is impaired (PubMed:23585538).
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

99287:STM4541
gene id: 99287:STM4541
uniprot id: Q8ZJX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OpgB family.
messages: Cell inner membrane
messages: Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones.

99287:STM0205
gene id: 99287:STM0205
uniprot id: Q7CR65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

99287:STM3354
gene id: 99287:STM3354
uniprot id: Q7CPN2
names: Similarity
messages: Belongs to the class-I fumarase family.

99287:STM2250
gene id: 99287:STM2250
uniprot id: Q8XG35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell inner membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

99287:STM1932
gene id: 99287:STM1932
uniprot id: Q7CQC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

99287:STM1727
gene id: 99287:STM1727
uniprot id: P00929
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

99287:STM1126
gene id: 99287:STM1126
uniprot id: Q7CQS0
names: Similarity
messages: Belongs to the PhoH family.

99287:STM4231
gene id: 99287:STM4231
uniprot id: P26466
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the porin LamB (TC 1.B.3) family.
messages: By maltose.
messages: Cell outer membrane
messages: Homotrimer formed of three 18-stranded antiparallel beta-barrels, containing three independent channels.
messages: Involved in the transport of maltose and maltodextrins. Does not act as a receptor for phages.

99287:STM2573
gene id: 99287:STM2573
uniprot id: Q8ZN23
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

99287:STM2383
gene id: 99287:STM2383
uniprot id: Q8ZNB0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M74 family.
messages: Binds 2 Zn(2+) ions per subunit. Zn(2+) ion 1 is bound in the active site. Zn(2+) ion 2 is bound at the dimer interface by residues from both subunits.
messages: Dimer.
messages: Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus.
messages: Periplasm

99287:STM3897
gene id: 99287:STM3897
uniprot id: P0A2Q0
names: Function
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.
messages: Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.

99287:STM3078
gene id: 99287:STM3078
uniprot id: P60656
names: Function
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.
messages: Catalyzes the formation of putrescine from agmatine.

99287:STM1352
gene id: 99287:STM1352
uniprot id: Q8ZPS0
names: Function
names: Similarity
messages: Belongs to the ETF-QO/FixC family.
messages: Part of an electron transfer system.

99287:STM2026
gene id: 99287:STM2026
uniprot id: Q05591
names: Function
names: Similarity
messages: Belongs to the precorrin-6x reductase family.
messages: Catalyzes the reduction of the macrocycle of cobalt-precorrin-6A to cobalt-precorrin-6B.

99287:STM0197
gene id: 99287:STM0197
uniprot id: H9L411
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

99287:STM1694
gene id: 99287:STM1694
uniprot id: P0A2J5
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
messages: Cell inner membrane
messages: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides.
messages: Loss of resistance to protamine.
messages: Part of the sapA-sapB-sapC-sapD-sapF operon, RNA detected in mid-log phase cells.

99287:STM0432
gene id: 99287:STM0432
uniprot id: Q7ZAP3
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. PhnX family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Induced when inorganic phosphate is limiting; this is controlled by PhoB.
messages: Involved in phosphonate degradation.
messages: Maps to a phosphate-starvation-inducible locus previously known as psiC.

99287:STM4036
gene id: 99287:STM4036
uniprot id: Q8ZKS9
names: Cofactor
names: Function
messages: Binds 4 [4Fe-4S] clusters per subunit.
messages: The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.

99287:STM4150
gene id: 99287:STM4150
uniprot id: P0A2A3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

99287:STM2062
gene id: 99287:STM2062
uniprot id: P37604
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S11 family.
messages: Cell inner membrane
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

99287:STM0855
gene id: 99287:STM0855
uniprot id: Q8ZQL9
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

99287:STM4579
gene id: 99287:STM4579
uniprot id: P24517
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Has a putative N-terminal zinc-finger, a middle region with homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

99287:STM2444
gene id: 99287:STM2444
uniprot id: P41031
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport (By similarity).
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

99287:STM4170
gene id: 99287:STM4170
uniprot id: P0A1R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.

99287:STM0741
gene id: 99287:STM0741
uniprot id: Q7CQX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

99287:STM0394
gene id: 99287:STM0394
uniprot id: Q8ZRE4
names: Subcellular Location Annotation
messages: Membrane

99287:STM2829
gene id: 99287:STM2829
uniprot id: P65977
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

99287:STM4090
gene id: 99287:STM4090
uniprot id: Q8ZKP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell inner membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

99287:STM3024
gene id: 99287:STM3024
uniprot id: Q8ZM94
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA subfamily.
messages: By nickel and cobalt. Transcriptionally repressed by RcnR (By similarity).
messages: Cell inner membrane
messages: Efflux system for nickel and cobalt.

99287:STM3718
gene id: 99287:STM3718
uniprot id: P19816
names: Function
names: Similarity
messages: Adds the galactose(I) group on the glucose(I) group of LPS.
messages: Belongs to the glycosyltransferase 8 family.

99287:STM2204
gene id: 99287:STM2204
uniprot id: Q8ZNK5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM0764
gene id: 99287:STM0764
uniprot id: Q8ZQS8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM0406
gene id: 99287:STM0406
uniprot id: Q7CR40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

99287:PSLT032
gene id: 99287:PSLT032
uniprot id: Q7DAP8
names: Similarity
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.

99287:STM2683
gene id: 99287:STM2683
uniprot id: P65774
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically inhibited by NADPH and NADH. NADPH is the primary inhibitor during aerobic growth and NADH during anaerobic growth.
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Equilibrium mixture of dimer and tetramer. It is converted entirely to tetramer in the presence of the inhibitor NADPH.
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates as a source of phosphorus. NADH cannot replace NAD as a substrate.

99287:STM1816
gene id: 99287:STM1816
uniprot id: P65363
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

99287:STM2889
gene id: 99287:STM2889
uniprot id: P0A1L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.

99287:STM3261
gene id: 99287:STM3261
uniprot id: Q8ZLU7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

99287:STM2490
gene id: 99287:STM2490
uniprot id: Q8ZN70
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM4060
gene id: 99287:STM4060
uniprot id: Q8ZKR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

99287:STM0833
gene id: 99287:STM0833
uniprot id: Q7CQV8
names: Similarity
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpX family.

99287:STM3197
gene id: 99287:STM3197
uniprot id: P58614
names: Function
names: Similarity
messages: Belongs to the GlgS family.
messages: Major determinant of cell surface composition. Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.

99287:STM4471
gene id: 99287:STM4471
uniprot id: Q08015
names: Caution
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MiaE family.
messages: Binding of tRNA to MiaE induces a protein conformational change that influences the electronic structure of the diiron site.
messages: Contains a nonheme dinuclear iron cluster (PubMed:17679698, PubMed:23906247, PubMed:25453905). Contains three different forms of the dinuclear site: an hydroxo-bridged FeIII-OH-FeIII center, an oxo-bridged FeIII-O-FeIII center and an hydroxo-bridged FeII-OH-FeIII mixed-valent center (PubMed:17679698).
messages: Disruption mutant shows normal growth characteristics after being shifted from anaerobic to aerobic conditions (PubMed:8253666). Mutant shows slower growth on citrate and acetate, and is unable to grow on the citric acid cycle intermediates succinate, fumarate and malate (PubMed:8253666, PubMed:9620964).
messages: Involved in specific tRNA modification. Catalyzes the oxygen-dependent hydroxylation of 2-methylthio-N-6-isopentenyl adenosine (ms2i6A) to produce 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A) at position 37 in tRNAs (PubMed:8253666, PubMed:17679698, PubMed:23906247). Can also use N6-(dimethylallyl)adenosine (i6A) as substrate, with lower efficiency (PubMed:23906247, PubMed:25453905). The presence of the hydroxyl group on the tRNA may regulate the ability of S.typhimurium to grow on the citric acid cycle (CAC) intermediates succinate, fumarate and malate (PubMed:9620964).
messages: It is uncertain whether Met-1 or Met-17 is the initiator.
messages: Monomer.

99287:STM2500
gene id: 99287:STM2500
uniprot id: H9L487
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

99287:STM3327
gene id: 99287:STM3327
uniprot id: Q8ZLR6
names: Function
names: Similarity
messages: Belongs to the peptidase C56 family.
messages: Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate.

99287:STM3003
gene id: 99287:STM3003
uniprot id: P37178
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Component of the phosphoenolpyruvate-dependent nitrogen-metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I-Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins. Enzyme I-Ntr is specific for NPr.
messages: Cytoplasm
messages: The EI N-terminal domain contains the HPr binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site.
messages: The GAF domain is an important site of signal perception in prokaryotes and eukaryotes.
messages: The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain.

99287:STM0123
gene id: 99287:STM0123
uniprot id: Q8ZRU7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm

99287:STM3963
gene id: 99287:STM3963
uniprot id: P0A1U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
messages: Cell inner membrane
messages: Uptake of biotin.

99287:STM3066
gene id: 99287:STM3066
uniprot id: Q8ZM68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
messages: Cell inner membrane
messages: Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine.

99287:STM2403
gene id: 99287:STM2403
uniprot id: Q93IM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

99287:STM2276
gene id: 99287:STM2276
uniprot id: P37431
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

99287:STM0776
gene id: 99287:STM0776
uniprot id: P22715
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.
messages: Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).

99287:STM0537
gene id: 99287:STM0537
uniprot id: Q8ZR68
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

99287:STM0243
gene id: 99287:STM0243
uniprot id: Q8ZRN2
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

99287:STM4076
gene id: 99287:STM4076
uniprot id: Q8ZKQ2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor.
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable).
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

99287:STM0964
gene id: 99287:STM0964
uniprot id: Q8ZQD3
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

99287:STM4341
gene id: 99287:STM4341
uniprot id: P67638
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FrdC family.
messages: Cell inner membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).
messages: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.

99287:STM1384
gene id: 99287:STM1384
uniprot id: Q9Z4S7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NrfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate. TtrC probably anchors TtrA and TtrB to the periplasmic face of the cytoplasmic membrane. May transfer electrons from membrane quinol to TtrB. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut.
messages: Probably composed of three subunits: TtrA, TtrB and TtrC.
messages: Transcriptionally regulated by Fnr and by the TtrR/TtrS two-component regulatory system.

99287:STM0411
gene id: 99287:STM0411
uniprot id: P0A1S8
names: Similarity
messages: Belongs to the HNH nuclease family.

99287:STM0993
gene id: 99287:STM0993
uniprot id: Q8ZQB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MukE family.
messages: Interacts, and probably forms a ternary complex, with MukF and MukB. The complex formation is stimulated by calcium or magnesium.
messages: Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.
messages: nucleoid

99287:STM2332
gene id: 99287:STM2332
uniprot id: Q8ZNE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5DNU family.
messages: Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
messages: Cytoplasm
messages: Homodimer.

99287:STM0208
gene id: 99287:STM0208
uniprot id: P40733
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dGTPase family. Type 1 subfamily.
messages: Homotetramer.
messages: dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs.

99287:STM2285
gene id: 99287:STM2285
uniprot id: Q8ZNG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic G-3-P dehydrogenase subunit B family.
messages: Cell inner membrane
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.

99287:STM2217
gene id: 99287:STM2217
uniprot id: Q7CQ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

99287:STM2198
gene id: 99287:STM2198
uniprot id: Q8ZNL1
names: Subcellular Location Annotation
messages: Membrane

99287:STM3800
gene id: 99287:STM3800
uniprot id: Q8ZL10
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM1599
gene id: 99287:STM1599
uniprot id: H9L442
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M15D family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.

99287:STM1822
gene id: 99287:STM1822
uniprot id: Q8ZP08
names: Similarity
messages: Belongs to the RutC family.

99287:STM3094
gene id: 99287:STM3094
uniprot id: Q8ZM52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

99287:STM2547
gene id: 99287:STM2547
uniprot id: Q8ZN39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Membrane

99287:STM1375
gene id: 99287:STM1375
uniprot id: Q8ZPQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YkuD family.
messages: Periplasm

99287:STM0669
gene id: 99287:STM0669
uniprot id: Q7CQY7
names: Similarity
messages: Belongs to the PhoH family.

99287:STM3639
gene id: 99287:STM3639
uniprot id: P43661
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm
messages: Required for the biogenesis of long polar fimbria; binds and interact with LpfA.

99287:STM0844
gene id: 99287:STM0844
uniprot id: Q8ZQM5
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

99287:STM1289
gene id: 99287:STM1289
uniprot id: Q8ZPV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glucose-6-phosphate 1-epimerase family.
messages: Monomer in solution.
messages: Probably functions as a hexose-6-phosphate 1-epimerase.

99287:STM2211
gene id: 99287:STM2211
uniprot id: P64046
names: Similarity
messages: Belongs to the elongation factor P family.

99287:STM2828
gene id: 99287:STM2828
uniprot id: Q8ZMK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

99287:STM2851
gene id: 99287:STM2851
uniprot id: Q8ZMI8
names: Subcellular Location Annotation
messages: Membrane

99287:STM0500
gene id: 99287:STM0500
uniprot id: Q7CR12
names: Subcellular Location Annotation
messages: Membrane

99287:STM1444
gene id: 99287:STM1444
uniprot id: P40676
names: Caution
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the SlyA family.
messages: During infection of the host cells. Down-regulated by itself. Activated by Mg(2+) starvation in a phoP dependent manner.
messages: Homodimer.
messages: Transcription regulator that can specifically activate or repress expression of target genes. Required for virulence and survival in the macrophage environment. Probably activates expression of ispA, xseB genes, and of omp operon.
messages: Was originally thought to be a toxin with hemolytic and cytolytic activity.

99287:STM1117
gene id: 99287:STM1117
uniprot id: O33921
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histidine acid phosphatase family.
messages: Homodimer.
messages: Periplasm

99287:STM0735
gene id: 99287:STM0735
uniprot id: Q8ZQU2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.
messages: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.

99287:STM2322
gene id: 99287:STM2322
uniprot id: Q60010
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

99287:STM1452
gene id: 99287:STM1452
uniprot id: Q8ZPM6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpA subfamily.
messages: Cell inner membrane
messages: Proton-dependent permease that transports di- and tripeptides.
messages: Transcriptionally activated by the EnvZ/OmpR regulatory system. Strongly stimulated under anaerobic conditions through an OmpR-independent mechanism.

99287:STM0600
gene id: 99287:STM0600
uniprot id: Q8ZR28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

99287:STM0442
gene id: 99287:STM0442
uniprot id: Q7CR27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane
messages: The cytochrome bo(3) ubiquinol oxidase complex is a heterooctamer of two A chains, two B chains, two C chains and two D chains.

99287:STM2579
gene id: 99287:STM2579
uniprot id: P0A285
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.
messages: Monomer.

99287:STM4109
gene id: 99287:STM4109
uniprot id: Q8ZKM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transaldolase family. Type 3A subfamily.
messages: Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction.
messages: Cytoplasm
messages: Homodecamer.

99287:STM0858
gene id: 99287:STM0858
uniprot id: Q8ZQL6
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

99287:STM3432
gene id: 99287:STM3432
uniprot id: P66170
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

99287:STM3664
gene id: 99287:STM3664
uniprot id: Q8ZL87
names: Cofactor
messages: Binds 1 Ca(2+) ion per subunit.

99287:STM0828
gene id: 99287:STM0828
uniprot id: Q7CQW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

99287:STM1643
gene id: 99287:STM1643
uniprot id: Q8ZP94
names: Similarity
messages: Belongs to the Gfa family.

99287:STM0451
gene id: 99287:STM0451
uniprot id: P0A1R8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.

99287:STM2267
gene id: 99287:STM2267
uniprot id: P0A263
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Forms pores that allow passive diffusion of small molecules across the outer membrane.
messages: Homotrimer.

99287:STM2873
gene id: 99287:STM2873
uniprot id: P41784
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SctF family.
messages: Binding of bile salts, including deoxycholate, to the PrgI:SipD interface may inhibit the T3SS function.
messages: Cell surface
messages: Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:16501225, PubMed:12754250, PubMed:30242280, PubMed:33750771). PrgI/SctF1 forms the external needle filament that protrudes from the bacterial surface (PubMed:16501225, PubMed:12754250, PubMed:22699623, PubMed:30242280, PubMed:31260457, PubMed:33750771). Is probably involved in the transduction of an activating signal, thought to be mediated by the distal tip of the needle filament, to the secretion machine (PubMed:31260457). Required for invasion of epithelial cells (PubMed:17617421). Required for the secretion of the effector protein SptP (PubMed:31260457, PubMed:33750771).
messages: Deletion of the last five residues prevents self-association and yields monomeric proteins that allow biophysical studies (PubMed:16501225, PubMed:17617421). Forms a right-handed helical assembly with roughly 11 subunits per two turns (PubMed:22699623, PubMed:30242280). The location of the negatively charged surfaces are radically different among the needle filament proteins PrgI, BsaL and MxiH (PubMed:17617421). In PrgI, the major negatively charged surface is not on the 'face' but instead is on the 'side' of the two-helix bundle, and only residues from helix alpha1 contribute to this negative region (PubMed:17617421). The insertion of the needle tip complex on the distal end of the filament results in significant conformational changes in PrgI/SctF (PubMed:34706941).
messages: During infection, can induce innate immune responses (PubMed:24643544). The needle proteins interact with host TLR2 or TLR4, and induce signaling by NF-kappa-B and/or AP-1 (PubMed:24643544). This activation is MyD88 dependent and results in increased expression of cytokines, including TNF-alpha, IL-6 and IL-8 (PubMed:24643544).
messages: Negatively regulated by PhoP-PhoQ.
messages: Secreted
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569, PubMed:30242280, PubMed:31427728). This subunit polymerizes and forms the helical needle filament (PubMed:16501225, PubMed:34258394, PubMed:20543831, PubMed:22699623, PubMed:30242280, PubMed:31427728, PubMed:31260457, PubMed:33750771, PubMed:34706941). Interacts with the needle tip protein SipD/SctA (PubMed:21829362, PubMed:34706941). Interacts with the needle adapter protein PrgJ/SctI, the secretin InvG/SctC and the minor export apparatus protein SpaP/SctR (PubMed:33750771). In vitro, the needle protomer refolds spontaneously to extend the needle from the distal end (PubMed:20543831).
messages: The levels of PrgI/SctF are reduced in an invA/sctV mutant, probably due to protein instability, and are increased in an invJ/sctP mutant.
messages: The null mutant strain is non-invasive.

99287:STM2924
gene id: 99287:STM2924
uniprot id: P0DM81
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: In strain JSG210 wild-type growth rate and motility, slightly increased biofilm production in vitro, does not persist in inoculated tomato cotyledons (cv. Tiny Tim seedlings). Wild-type strain JSG210 has high persistence in tomato plant organs; fresh produce contaminated with Salmonella contributes to food safety risks.
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

99287:STM0116
gene id: 99287:STM0116
uniprot id: P40811
names: Activity Regulation
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Contains 1 molecule of FAD per monomer. The role of this cofactor is not clear considering that the reaction does not involve redox chemistry (By similarity).
messages: Dimer of chain H and chain I.
messages: S.typhimurium contains genes for 3 AHAS isozymes: ilvBN, ilvGM and ilvIH.
messages: Sensitive to valine inhibition.

99287:STM0423
gene id: 99287:STM0423
uniprot id: Q8ZRD0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

99287:STM4349
gene id: 99287:STM4349
uniprot id: Q8ZKB0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

99287:STM0034
gene id: 99287:STM0034
uniprot id: Q8ZRZ8
names: Similarity
messages: Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.

99287:STM1409
gene id: 99287:STM1409
uniprot id: P74852
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YscJ lipoprotein family.
messages: Cell outer membrane
messages: Component of Salmonella pathogenicity island 2 (SPI-2) type III secretion system, required for secretion of some type III-secreted effectors including the SpvB toxin.
messages: Disruption prevents SpvB-induced F-actin depolymerization in human macrophages without affecting intra-bacterial SpvB protein levels.

99287:STM3296
gene id: 99287:STM3296
uniprot id: P63343
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

99287:STM1173
gene id: 99287:STM1173
uniprot id: P40131
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

99287:STM4344
gene id: 99287:STM4344
uniprot id: Q9ZJ12
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
messages: Homodimer.
messages: Mutants have a reduced pyruvate oxidase activity and a reduced growth rate, and are highly attenuated for virulence in mouse models of infection. Salmonella epmA and epmB mutants share extensive phenotypic pleiotropy, including an increased ability to respire under nutrient-limiting conditions, hypersusceptibility to a variety of diverse growth inhibitors, and altered expression of multiple proteins, including several encoded on the SPI-1 pathogenicity island.
messages: With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34' (Probable). Can also use L-alpha-lysine as a substrate, but probably with lower efficiency. Cannot aminoacylate tRNA(Lys) with lysine.

99287:STM4264
gene id: 99287:STM4264
uniprot id: Q8ZKG4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.
messages: Membrane

99287:STM2450
gene id: 99287:STM2450
uniprot id: P33772
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.
messages: Cell-wall hydrolase involved in septum cleavage during cell division.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

99287:STM1124
gene id: 99287:STM1124
uniprot id: P10503
names: Function
names: Induction
names: Similarity
messages: By proline, autorepression and catabolite repression, and is potentially nitrogen controlled.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family.
messages: In the N-terminal section; belongs to the proline dehydrogenase family.
messages: Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon.

99287:STM2324
gene id: 99287:STM2324
uniprot id: P33901
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 51 kDa subunit family.
messages: Binds 1 FMN.
messages: Binds 1 [4Fe-4S] cluster.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

99287:STM1850
gene id: 99287:STM1850
uniprot id: Q8ZNZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.

99287:STM0386
gene id: 99287:STM0386
uniprot id: Q8ZRF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

99287:STM0181
gene id: 99287:STM0181
uniprot id: Q8ZRR1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

99287:STM2960
gene id: 99287:STM2960
uniprot id: Q8ZMD9
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.

99287:STM2812
gene id: 99287:STM2812
uniprot id: Q8ZML0
names: Subcellular Location Annotation
messages: Membrane

99287:STM0132
gene id: 99287:STM0132
uniprot id: Q7CR80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

99287:STM4299
gene id: 99287:STM4299
uniprot id: P30878
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apoprotein is apparently conformationally labile and readily converts to different states, including inward-facing conformations for substrate access (PubMed:34110360). Contains a conserved cation-binding pocket, which directly connects to the sugar specificity pocket (PubMed:34341464).
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Binding of Na(+) and melibiose is cooperative, the binding affinity for one substrate is increased by the presence of the other (PubMed:29054867, PubMed:34110360). With binding of one substrate (either Na(+) or melibiose), MelB favors open conformations (likely outward facing), whereas the cooperative binding of both substrates induces cavity closure. Thus, cooperative binding is the key that regulates the alternating-access process and ensures the obligatory cotransport as the core mechanism for symport (PubMed:34110360). Melibiose uptake is inhibited by valinomycin (PubMed:21148559).
messages: Cell inner membrane
messages: Mediates the transport of melibiose and other galactosides by a symport mechanism (PubMed:21148559, PubMed:24389923, PubMed:29054867, PubMed:34110360). Can use sodium, lithium and protons as coupling cations, with a preference for sodium and lithium (PubMed:21148559, PubMed:24389923, PubMed:29054867). The use of Na(+) as coupling ion for sugar transport is based not on ion selectivity but on competitive binding under physiological conditions, because of a much higher Na(+) concentration under physiological conditions (PubMed:29054867).

99287:STM1839
gene id: 99287:STM1839
uniprot id: P64501
names: Subcellular Location Annotation
messages: Cell membrane

99287:STM3691
gene id: 99287:STM3691
uniprot id: Q8ZL64
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.
messages: Cell outer membrane
messages: Cell surface
messages: Homotrimer.
messages: Immunization of mice with folded, full-length, purified SadA elicits an IgG response which provides limited protection against bacterial challenge.
messages: In vitro, loss of sadA does not affect cell aggregation, biofilm formation and adhesion to epithelial cells. Disruption does not affect the course of infection.
messages: Involved in cell aggregation, biofilm formation, and adhesion to human intestinal epithelial cells.
messages: The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface (By similarity). The surface exposed region contains four YadA-like head domains and extended stalk regions, multiply segmented by FGG, HANS, DALL and neck motifs (PubMed:23213248).

99287:STM3056
gene id: 99287:STM3056
uniprot id: Q8ZM74
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

99287:STM3385
gene id: 99287:STM3385
uniprot id: P0A6R6
names: Function
names: Similarity
names: Subunit
messages: Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.
messages: Belongs to the transcriptional regulatory Fis family.
messages: Homodimer.

99287:STM0292
gene id: 99287:STM0292
uniprot id: Q8ZRK9
names: Similarity
messages: Belongs to the RHS family.

99287:STM0498
gene id: 99287:STM0498
uniprot id: Q8ZR95
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Causes a mild defect in aerobic growth on CuSO(4), strongly impairs survival during anaerobic growth on CuSO(4).
messages: Cell inner membrane
messages: Cytoplasm
messages: Expression of the CopA(Z) soluble copper chaperone isoform requires a -1 programmed ribosomal frameshift (PRF) at the 70th codon. A nucleotide 'slippery sequence' that promotes PRF is found just downstream of the frameshifted site.
messages: Involved in Cu(+) export (By similarity). Essential for copper tolerance under both aerobic and anaerobic conditions (PubMed:17768242).
messages: Probably also encodes a cytoplasmic copper chaperone CopA(Z) that is produced by programmed ribosomal frameshifting (Probable).
messages: Transcriptionally up-regulated by CueR in response to copper ions.

99287:STM3059
gene id: 99287:STM3059
uniprot id: Q8ZM71
names: Similarity
messages: Belongs to the UPF0149 family.

99287:STM1241
gene id: 99287:STM1241
uniprot id: P0A1G3
names: Function
names: Similarity
messages: Affects survival in macrophages.
messages: Belongs to the DinI family.

99287:STM3624
gene id: 99287:STM3624
uniprot id: Q7CPI7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Required for cellulose biosynthesis.

99287:STM2405
gene id: 99287:STM2405
uniprot id: H9L492
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

99287:STM1707
gene id: 99287:STM1707
uniprot id: P07691
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

99287:STM1907
gene id: 99287:STM1907
uniprot id: Q8ZNV0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Homodimer.
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

99287:STM0848
gene id: 99287:STM0848
uniprot id: Q8ZQM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Glutathione importer (TC 3.A.1.5.11) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).

99287:STM1602
gene id: 99287:STM1602
uniprot id: Q9KIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Sif family.
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.
messages: Host cytoplasm
messages: Secreted

99287:STM1256
gene id: 99287:STM1256
uniprot id: Q8ZPY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

99287:STM3808
gene id: 99287:STM3808
uniprot id: Q8ZL03
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Homodimer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to oligomers at high temperatures or high ionic concentrations. The decrease in size of the multimers is accompanied by an increase in chaperone activity.
messages: The N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity.

99287:STM2929
gene id: 99287:STM2929
uniprot id: Q8ZMF7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

99287:STM4241
gene id: 99287:STM4241
uniprot id: Q8ZKH6
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

99287:STM1223
gene id: 99287:STM1223
uniprot id: Q7CQQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

99287:STM3809
gene id: 99287:STM3809
uniprot id: Q7CPF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Monomer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to monomers at high temperatures or high ionic concentrations.

99287:STM3469
gene id: 99287:STM3469
uniprot id: P06193
names: Function
names: Subunit
messages: Monomer. Heterodimer consisting of two non-identical subunits: a glutamine amidotransferase subunit (PabA) and a aminodeoxychorismate synthase subunit (PabB) (By similarity).
messages: Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB (By similarity).

99287:STM2318
gene id: 99287:STM2318
uniprot id: Q8ZNE2
names: Subcellular Location Annotation
messages: Membrane

99287:STM1482
gene id: 99287:STM1482
uniprot id: Q7CQK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily.
messages: Catalyzes the excretion of spermidine.
messages: Cell inner membrane
messages: Forms a complex with MdtI.

99287:STM3870
gene id: 99287:STM3870
uniprot id: P68704
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: Dicyclohexylcarbodiimide (DCDD) binding to the active aspartate residue inhibits ATPase in vitro.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.

99287:STM4139
gene id: 99287:STM4139
uniprot id: Q9L9K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

99287:STM2224
gene id: 99287:STM2224
uniprot id: Q7CQ71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

99287:STM1845
gene id: 99287:STM1845
uniprot id: P43669
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S41A family.
messages: Cell inner membrane
messages: Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses (By similarity).

99287:STM3167
gene id: 99287:STM3167
uniprot id: Q8ZM04
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM3826
gene id: 99287:STM3826
uniprot id: Q8ZKZ3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM2015
gene id: 99287:STM2015
uniprot id: P40680
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YkuD family.
messages: Periplasm

99287:STM0943
gene id: 99287:STM0943
uniprot id: Q7CQU7
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM1487
gene id: 99287:STM1487
uniprot id: Q8ZPK8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM1823
gene id: 99287:STM1823
uniprot id: P0A2M3
names: Similarity
messages: Belongs to the UPF0181 family.

99287:STM0730
gene id: 99287:STM0730
uniprot id: O68883
names: Activity Regulation
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically inhibited by NADH.
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Homohexamer.

99287:STM1883
gene id: 99287:STM1883
uniprot id: Q8ZNW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

99287:STM0161
gene id: 99287:STM0161
uniprot id: P65207
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdgT transporter family.
messages: Catalyzes the proton-dependent uptake of 2-keto-3-deoxygluconate (KDG) into the cell.
messages: Cell inner membrane

99287:STM1504
gene id: 99287:STM1504
uniprot id: Q8ZPJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell inner membrane

99287:STM0978
gene id: 99287:STM0978
uniprot id: P07637
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

99287:STM4260
gene id: 99287:STM4260
uniprot id: H9L452
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

99287:STM0005
gene id: 99287:STM0005
uniprot id: Q8ZS17
names: Similarity
messages: Belongs to the UPF0246 family.

99287:STM3040
gene id: 99287:STM3040
uniprot id: P28354
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

99287:STM1969
gene id: 99287:STM1969
uniprot id: P15928
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Cell inner membrane
messages: Inhibited in nutrient-poor medium.
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

99287:STM0070
gene id: 99287:STM0070
uniprot id: Q8ZRX5
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.

99287:STM0368
gene id: 99287:STM0368
uniprot id: Q56062
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Cells lacking this gene are unable to accumulate 2-methylcitrate and 2-methyl-cis-aconitate.
messages: Homotetramer; dimer of dimers.
messages: In vitro, dithiothreitol (DTT) or reduced glutathione (GSH) are required for optimal activity.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.

99287:STM4115
gene id: 99287:STM4115
uniprot id: Q8ZKM3
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

99287:STM2472
gene id: 99287:STM2472
uniprot id: Q9ZFV8
names: Cofactor
names: Similarity
messages: Divalent metal cations. Prefers magnesium or manganese.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

99287:STM2317
gene id: 99287:STM2317
uniprot id: Q8ZNE3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: Membrane

99287:STM2206
gene id: 99287:STM2206
uniprot id: P17127
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In contrast to classical PTS systems, the fructose-specific PTS has no requirement for HPr; FruB combines a IIA domain with a HPr domain.
messages: Induced by fructose and repressed by FruR.
messages: The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.

99287:STM4220
gene id: 99287:STM4220
uniprot id: Q8ZKI5
names: Similarity
messages: Belongs to the aspartokinase family.

99287:STM1955
gene id: 99287:STM1955
uniprot id: P0A210
names: Function
messages: May regulate sigma factor activity.

99287:STM1154
gene id: 99287:STM1154
uniprot id: Q8ZQ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily.
messages: Cell inner membrane

99287:STM4409
gene id: 99287:STM4409
uniprot id: Q7CP88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TamA family.
messages: Cell outer membrane
messages: Membrane

99287:STM0469
gene id: 99287:STM0469
uniprot id: P66193
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

99287:STM1656
gene id: 99287:STM1656
uniprot id: Q9EYX5
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A role in zinc efflux has been proposed by Worlock et al, but ZntB was later shown in E.coli to likely mediate zinc uptake, using a transport mechanism that does not resemble the one proposed for homologous CorA channels.
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell inner membrane
messages: Disruption of the gene has a marked effect on resistance levels to zinc and cadmium, but does not significantly alter the sensitivities to cobalt, nickel or manganese.
messages: Forms a funnel-like structure. Contains three Zn(2+) binding sites, two of which could be involved in Zn(2+) transport.
messages: Homopentamer (PubMed:21565704). Can assemble pentamers in the absence of the transmembrane regions (PubMed:21565704).
messages: Zinc transporter (PubMed:12142406). Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake (By similarity).

99287:STM3447
gene id: 99287:STM3447
uniprot id: P0A2B3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11 (By similarity). Binds EngA (AC Q9XCI8).

99287:STM3834
gene id: 99287:STM3834
uniprot id: Q8ZKY5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM2372
gene id: 99287:STM2372
uniprot id: Q8ZNB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. YfcJ family.
messages: Cell inner membrane

99287:STM1833
gene id: 99287:STM1833
uniprot id: Q8ZP01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0266 family.
messages: Cell inner membrane

99287:STM0483
gene id: 99287:STM0483
uniprot id: Q8ZRA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

99287:STM3938
gene id: 99287:STM3938
uniprot id: P0A1Q8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

99287:STM4074
gene id: 99287:STM4074
uniprot id: Q8ZKQ4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3.A.1.2.8) family.
messages: Cell inner membrane
messages: In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor.
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

99287:STM0952
gene id: 99287:STM0952
uniprot id: Q7CQU6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM0033
gene id: 99287:STM0033
uniprot id: Q7CR96
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

99287:STM4350
gene id: 99287:STM4350
uniprot id: P65599
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

99287:STM2867
gene id: 99287:STM2867
uniprot id: P0CL09
names: Function
messages: Positive regulator of the expression of the invasion-associated type III secretion system encoded within SPI-1 (pathogenicity island 1).

99287:STM2524
gene id: 99287:STM2524
uniprot id: Q8ZN53
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RodZ family.
messages: Cell inner membrane
messages: Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
messages: The helix-turn-helix (HTH) motif in the cytoplasmic domain of the N-terminus is involved in the formation of spirals to maintain the rigid rod shape. As this protein is anchored in the cytoplasmic membrane, the HTH motif may contribute to protein-protein interactions to form the RodZ helix, which is localized beneath the cytoplasmic membrane. The C-terminal domain may be critical for determination of the rod shape by probably interacting with enzymes required for synthesis of the peptidoglycan layer, including PBPs in the periplasm.

99287:STM0745
gene id: 99287:STM0745
uniprot id: Q7CQX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

99287:STM0398
gene id: 99287:STM0398
uniprot id: Q8ZRE1
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

99287:STM1479
gene id: 99287:STM1479
uniprot id: Q8ZPL0
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

99287:STM3352
gene id: 99287:STM3352
uniprot id: Q03030
names: Function
names: Subunit
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Composed of three chains (alpha, beta, and gamma).

99287:STM3576
gene id: 99287:STM3576
uniprot id: Q8ZLE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

99287:STM3260
gene id: 99287:STM3260
uniprot id: Q8ZLU8
names: Subcellular Location Annotation
messages: Membrane

99287:STM0740
gene id: 99287:STM0740
uniprot id: Q8ZQT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

99287:STM3939
gene id: 99287:STM3939
uniprot id: P0A1A7
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-1 family.
messages: Cytoplasm
messages: The regulatory domain is involved in the regulation of cyclase activity by the carbon source. Activated by the PTS system, glucose-specific IIA component (CRR).

99287:STM0158
gene id: 99287:STM0158
uniprot id: Q8ZRS8
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Cells lacking this gene do not grow on propionate unless glutamate is added, and the addition of glutamate does not restore growth to the level of wild-type. Also unable to grow on acetate and citrate and only slight improvements are observed when glutamate is added. AcnB mutant also shows an impaired binding to the surface of macrophage-like cells, is less motile and possesses fewer flagella due to a level of the flagellum protein FliC lower. The acnAB double mutant does not grow on propionate even when supplemented with glutamate and is unable to respire propionate under anaerobic growth conditions.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Also catalyzes the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein which regulates FliC synthesis via interaction with the ftsH transcript to decrease the intracellular levels of FtsH. The lower levels of FtsH protease activity then influence sigma-32, DnaK and ultimately FliC production.
messages: Monomer.

99287:STM4339
gene id: 99287:STM4339
uniprot id: Q8ZKB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Cell outer membrane
messages: Homodimer.
messages: Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.

99287:STM3195
gene id: 99287:STM3195
uniprot id: P66032
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

99287:PSLT017
gene id: 99287:PSLT017
uniprot id: P37868
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Involved in the export and assembly of FimA fimbrial subunits across the outer membrane.

99287:STM4323
gene id: 99287:STM4323
uniprot id: Q8ZKC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

99287:STM1750
gene id: 99287:STM1750
uniprot id: Q7CQF3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

99287:STM1909
gene id: 99287:STM1909
uniprot id: P0CL51
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

99287:STM1348
gene id: 99287:STM1348
uniprot id: P67197
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

99287:STM1378
gene id: 99287:STM1378
uniprot id: P77983
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Belongs to type I PK; fructose 1,6-bisphosphate-activated.
messages: Catalyzes the formation of pyruvate in the last step of glycolysis, it is irreversible under physiological conditions. The reaction is critical for the control of metabolic flux in the second part of glycolysis.
messages: Homotetramer.

99287:STM0595
gene id: 99287:STM0595
uniprot id: Q8ZR33
names: Similarity
messages: Belongs to the isochorismate synthase family.

99287:STM0962
gene id: 99287:STM0962
uniprot id: Q7CQU4
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

99287:STM1881
gene id: 99287:STM1881
uniprot id: Q8ZNW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YebF family.
messages: Secreted

99287:STM3487
gene id: 99287:STM3487
uniprot id: P63601
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

99287:STM4004
gene id: 99287:STM4004
uniprot id: P0A1E1
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cells lacking this gene accumulate coproporphyrinogen III under anaerobic conditions.
messages: Cytoplasm
messages: Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
messages: Monomer.

99287:STM4268
gene id: 99287:STM4268
uniprot id: Q8ZKG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

99287:STM0880
gene id: 99287:STM0880
uniprot id: Q8ZQJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

99287:STM3731
gene id: 99287:STM3731
uniprot id: P64008
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

99287:STM0488
gene id: 99287:STM0488
uniprot id: P0A1V4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

99287:STM3029
gene id: 99287:STM3029
uniprot id: Q8ZM89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM0642
gene id: 99287:STM0642
uniprot id: Q7CQZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

99287:STM3955
gene id: 99287:STM3955
uniprot id: Q9L6P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Cell inner membrane

99287:STM0736
gene id: 99287:STM0736
uniprot id: Q8ZQU1
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

99287:STM1287
gene id: 99287:STM1287
uniprot id: Q8ZPW1
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

99287:STM1177
gene id: 99287:STM1177
uniprot id: P0A1J1
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

99287:STM3372
gene id: 99287:STM3372
uniprot id: Q7CPM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

99287:STM3789
gene id: 99287:STM3789
uniprot id: P27668
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Cell inner membrane
messages: Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as a membrane-associated protein kinase that autophosphorylates in response to interaction with UhpC, and subsequently transfers its phosphate group to the response regulator UhpA. Can also dephosphorylate UhpA.

99287:STM4485
gene id: 99287:STM4485
uniprot id: Q8ZK21
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

99287:STM1596
gene id: 99287:STM1596
uniprot id: Q8ZPD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GhoT/OrtT toxin family.
messages: Cell inner membrane
messages: Membrane

99287:STM2473
gene id: 99287:STM2473
uniprot id: Q8ZN83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

99287:STM4183
gene id: 99287:STM4183
uniprot id: Q8ZKL4
names: Similarity
messages: Belongs to the malate synthase family.

99287:STM2816
gene id: 99287:STM2816
uniprot id: Q8ZMK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the porin LamB (TC 1.B.3) family.
messages: Membrane

99287:STM0728
gene id: 99287:STM0728
uniprot id: P0CL05
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

99287:STM1484
gene id: 99287:STM1484
uniprot id: Q7CQJ9
names: Similarity
messages: Belongs to the peptidase S1B family.

99287:STM1777
gene id: 99287:STM1777
uniprot id: P0A1Q6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

99287:STM1314
gene id: 99287:STM1314
uniprot id: Q8ZPU3
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

99287:STM0174
gene id: 99287:STM0174
uniprot id: Q8ZRR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM2845
gene id: 99287:STM2845
uniprot id: Q8ZMJ3
names: Similarity
messages: Belongs to the peptidase A31 family.

99287:STM3324
gene id: 99287:STM3324
uniprot id: Q7CPN7
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM4368
gene id: 99287:STM4368
uniprot id: Q7CP94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm
messages: Monomer.

99287:STM1919
gene id: 99287:STM1919
uniprot id: P02941
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane
messages: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.
messages: Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar mediates taxis away from the repellents cobalt and nickel. Unlike in E.coli tar, it does not mediate maltose taxis.

99287:STM3067
gene id: 99287:STM3067
uniprot id: Q7CPU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

99287:STM2771
gene id: 99287:STM2771
uniprot id: P52616
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes.
messages: Secreted

99287:STM4213
gene id: 99287:STM4213
uniprot id: Q8ZKJ2
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

99287:STM2189
gene id: 99287:STM2189
uniprot id: P23924
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.
messages: Stimulated 3-fold by galactose and inhibited by vanadate, N-ethylmaleimide, and 5-methoxyindole-2-carboxylic acid.
messages: The complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

99287:STM0416
gene id: 99287:STM0416
uniprot id: Q8ZRD4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

99287:STM4303
gene id: 99287:STM4303
uniprot id: Q8ZKD9
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM1308
gene id: 99287:STM1308
uniprot id: Q8ZPU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

99287:STM1221
gene id: 99287:STM1221
uniprot id: P0A2F2
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 residues (Tyr-92 and Arg-95) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: 5- to 20-fold higher levels of this protein are seen in rich and minimal media.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Both isoforms are monomers (PubMed:20889757).
messages: Cytoplasm
messages: Most expressed in mid- to late-log growth phases (at protein level) (PubMed:20889757). Has 3 promoters, P1 (upstream of nagK) gives rise to a nagK-cobB transcript, P2 (within the nagK coding region) gives rise to a transcript able to generate both CobB isoforms, while P3 (nucleotide 44 of the long isoform) can only give rise to the CobB-Short isoform (PubMed:20889757).
messages: NAD-dependent lysine deacetylase that specifically removes acetyl groups on target proteins. Also acts as a protein-lysine deacylase by mediating protein desuccinylation and de-2-hydroxyisobutyrylation. Modulates the activities of several proteins which are inactive in their acylated form (By similarity). Activates the enzyme acetyl-CoA synthetase (acs) by deacetylating 'Lys-609' in the inactive, acetylated form of the enzyme (PubMed:12493915, PubMed:20889757, PubMed:12700259). May also modulate the activity of other propionyl-adenosine monophosphate (AMP)-forming enzymes such as propionate--CoA ligase (prpE) (PubMed:12493915, PubMed:12700259). Overexpression compensates for a cobT deletion, suggesting it may have N(1)-alpha-phosphoribosyltransferase activity; alternatively this protein may stimulate synthesis of an enzyme with the CobT activity (PubMed:9822644).
messages: Originally isolated genetically as functioning in cobalamin biosynthesis and in propionate catabolism (PubMed:8206834, PubMed:8955330).
messages: Single mutant grows on cobinamide (CBI), CBI plus 5,6-dimethylbenzimidazole (DMB) and cobalamin (CBL); double cobB-cobT deletion mutants do not grow on CBI plus DMB (PubMed:8206834). Single mutant does not grow on propionate (PubMed:8955330). Acetyl-CoA synthetase (acs) accumulates in an inactive, acetylated form (PubMed:12493915). Considerably decreased growth on 1,2-propanediol, cells do not excrete more propanediol than wild-type (PubMed:12700259).
messages: The less prevalent isoform.

99287:STM2359
gene id: 99287:STM2359
uniprot id: Q8ZNC5
names: Subcellular Location Annotation
messages: Membrane

99287:STM1696
gene id: 99287:STM1696
uniprot id: P36638
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides.
messages: Loss of resistance to protamine.
messages: Part of the sapA-sapB-sapC-sapD-sapF operon, RNA detected in mid-log phase cells.

99287:STM3438
gene id: 99287:STM3438
uniprot id: Q7CPL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

99287:STM2791
gene id: 99287:STM2791
uniprot id: Q8ZMM2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

99287:STM1692
gene id: 99287:STM1692
uniprot id: P36634
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides.
messages: More senstitive to protamine than wild-type cells, but not as sensitive as sapC, sapD or sapF deletions.
messages: Part of the sapA-sapB-sapC-sapD-sapF operon, RNA detected in mid-log phase cells.
messages: Periplasm

99287:STM0882
gene id: 99287:STM0882
uniprot id: Q8ZQJ5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.

99287:STM0420
gene id: 99287:STM0420
uniprot id: Q7CR35
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

99287:STM3110
gene id: 99287:STM3110
uniprot id: Q05869
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Monomer.

99287:STM3925
gene id: 99287:STM3925
uniprot id: Q9L6R0
names: Function
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.
messages: Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D-galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D-Glc4O) and L-glutamate.

99287:STM4280
gene id: 99287:STM4280
uniprot id: Q8ZKF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

99287:STM0361
gene id: 99287:STM0361
uniprot id: Q8ZRG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

99287:STM0626
gene id: 99287:STM0626
uniprot id: Q8ZR08
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM3190
gene id: 99287:STM3190
uniprot id: P67470
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell inner membrane
messages: Expressed at basal levels in rich medium (PubMed:24430377). Expression increases under zinc limiting conditions (PubMed:24430377).
messages: Mediates zinc uptake (PubMed:24430377). May also transport other divalent cations (Probable). Contributes to zinc acquisition during infection and plays a role in the ability of S.typhimurium to colonize the host tissues (PubMed:24430377).
messages: Mutant lacking this gene is impaired in its ability to grow in metal devoid environments (PubMed:24430377). Mutant lacking znuABC and zupT exhibits a severe growth defect in zinc devoid media, is hypersensitive to oxidative stress and contains reduced levels of intracellular free zinc (PubMed:24430377).

99287:STM0407
gene id: 99287:STM0407
uniprot id: Q8ZRD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

99287:STM0011
gene id: 99287:STM0011
uniprot id: Q8ZS14
names: Similarity
messages: Belongs to the UPF0412 family.

99287:STM2333
gene id: 99287:STM2333
uniprot id: Q8ZND9
names: Subcellular Location Annotation
messages: Membrane

99287:STM2182
gene id: 99287:STM2182
uniprot id: Q7CQ80
names: Subcellular Location Annotation
messages: Membrane

99287:STM0849
gene id: 99287:STM0849
uniprot id: Q8ZQM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB).

99287:STM0171
gene id: 99287:STM0171
uniprot id: Q8ZRS0
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

99287:STM3712
gene id: 99287:STM3712
uniprot id: P26469
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 9 family.
messages: Heptose transfer to the lipopolysaccharide core. It transfers the innermost heptose to [4'-P](3-deoxy-D-manno-octulosonic acid)2-IVA.

99287:STM1442
gene id: 99287:STM1442
uniprot id: Q8ZPN3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

99287:STM2561
gene id: 99287:STM2561
uniprot id: P0A9Z4
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the P(II) protein family.
messages: Homotrimer.
messages: P-II indirectly controls the transcription of the glutamine synthetase gene (GlnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity).
messages: Uridylylated/deuridylylated by GlnD.

99287:STM3591
gene id: 99287:STM3591
uniprot id: Q8ZLD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm
messages: Homodimer.
messages: Required for resistance to DNA-damaging agents.

99287:STM3370
gene id: 99287:STM3370
uniprot id: Q7CPM4
names: Similarity
messages: Belongs to the RNase E/G family. RNase G subfamily.

99287:STM4017
gene id: 99287:STM4017
uniprot id: Q9L7R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Cell inner membrane
messages: Could be involved in sulfoquinovose import.

99287:STM3735
gene id: 99287:STM3735
uniprot id: Q7CPH3
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the YicC/YloC family.
messages: In strain JSG210, wild-type growth rate and motility, increased biofilm production in vitro, decreased persistence in inoculated tomato cotyledons (cv. Tiny Tim seedlings). Wild-type strain JSG210 has high persistence in tomato plant organs; fresh produce contaminated with Salmonella contributes to food safety risks.
messages: Might contribute to small RNA (sRNA) regulation.
messages: Probably a ssRNA endonuclease.

99287:STM2398
gene id: 99287:STM2398
uniprot id: P0A233
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins.

99287:STM2443
gene id: 99287:STM2443
uniprot id: P41032
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

99287:STM3270
gene id: 99287:STM3270
uniprot id: P60822
names: Similarity
messages: Belongs to the UPF0306 family.

99287:STM0816
gene id: 99287:STM0816
uniprot id: Q7CQW4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM1584
gene id: 99287:STM1584
uniprot id: P40812
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Cell inner membrane

99287:STM4394
gene id: 99287:STM4394
uniprot id: Q8ZK80
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

99287:STM2150
gene id: 99287:STM2150
uniprot id: Q8ZNN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

99287:STM1925
gene id: 99287:STM1925
uniprot id: P0A2R2
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 1.5-fold induced in nutrient-poor medium.
messages: Belongs to the FlhD family.
messages: Cytoplasm
messages: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (Probable).
messages: Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers (Probable). This subunit binds DNA and interacts with YdiV, which decreases its ability to bind DNA.
messages: The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.

99287:STM0162
gene id: 99287:STM0162
uniprot id: Q8ZRS5
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of D-threonate to D-threonate 4-phosphate (PubMed:27402745). Can also phosphorylate 4-hydroxy-L-threonine, with lower efficiency. This side reaction may serve to deal with the toxicity of 4-hydroxy-L-threonine by converting it into 4-hydroxy-L-threonine 4-phosphate, a useful product that can be used by PdxA2 (PubMed:27402745, PubMed:27294475).
messages: Deletion mutant is unable to use D-threonate as a carbon source.

99287:STM4043
gene id: 99287:STM4043
uniprot id: Q7CPC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rhamnose mutarotase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the anomeric conversion of L-rhamnose.

99287:STM1739
gene id: 99287:STM1739
uniprot id: P63798
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell inner membrane

99287:STM3166
gene id: 99287:STM3166
uniprot id: Q8ZM05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

99287:STM3864
gene id: 99287:STM3864
uniprot id: P0A1B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

99287:STM0009
gene id: 99287:STM0009
uniprot id: Q7CRA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

99287:STM3910
gene id: 99287:STM3910
uniprot id: P0A265
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PpiC/parvulin rotamase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates (By similarity).

99287:STM2044
gene id: 99287:STM2044
uniprot id: Q8ZNR6
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the DdrB/PduH family.
messages: Forms a heterotetramer PduG(2)/PduH(2).
messages: Small subunit of the propanediol dehydratase-reactivating factor (DDR), which reactivates suicidally inhibited adenosylcobalamin-dependent propanediol dehydratase (diol dehydratase, DDH) found in the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. Reactivates inactivated DDH in the presence of ATP, Mg(2+) and free adenosylcobalamin (AdoCbl), by mediating the exchange of the tightly bound damaged cofactor AdoCbl for a free intact one.
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.

99287:STM1270
gene id: 99287:STM1270
uniprot id: Q7CQP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rht family.
messages: Cell inner membrane
messages: Exporter of leucine.

99287:STM1244
gene id: 99287:STM1244
uniprot id: Q56029
names: Function
messages: Putative function in virulence. Could be involved in promoting S.typhimurium survival within macrophages.

99287:STM3342
gene id: 99287:STM3342
uniprot id: Q8ZLQ5
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

99287:STM1194
gene id: 99287:STM1194
uniprot id: O85140
names: Similarity
messages: Belongs to the FabD family.

99287:STM1095
gene id: 99287:STM1095
uniprot id: Q8ZQ54
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Member of a two-component regulatory system.

99287:STM2890
gene id: 99287:STM2890
uniprot id: P40700
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.

99287:STM2392
gene id: 99287:STM2392
uniprot id: Q7CQ32
names: Similarity
messages: Belongs to the MlaA family.

99287:STM0637
gene id: 99287:STM0637
uniprot id: Q8ZR02
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

99287:STM0852
gene id: 99287:STM0852
uniprot id: Q8ZQM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

99287:STM4227
gene id: 99287:STM4227
uniprot id: P26468
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE).

99287:STM1615
gene id: 99287:STM1615
uniprot id: Q8ZPB8
names: Similarity
messages: Belongs to the BtpA family.

99287:STM3724
gene id: 99287:STM3724
uniprot id: Q8ZL49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

99287:STM1358
gene id: 99287:STM1358
uniprot id: P58687
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Inhibited by (2R)-2-methyl-3-dehydroquinic acid.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsilon-amino group of a Lys-170 at the active site.

99287:STM3445
gene id: 99287:STM3445
uniprot id: P0A1H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

99287:STM1369
gene id: 99287:STM1369
uniprot id: Q8ZPQ5
names: Similarity
messages: Belongs to the HesB/IscA family.

99287:STM0371
gene id: 99287:STM0371
uniprot id: P55912
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity.

99287:STM1546
gene id: 99287:STM1546
uniprot id: Q8ZPG3
names: Function
messages: Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.

99287:STM2289
gene id: 99287:STM2289
uniprot id: Q8ZNG0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.
messages: Homohexamer.

99287:STM0117
gene id: 99287:STM0117
uniprot id: P21622
names: Activity Regulation
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Dimer of large and small chains.
messages: S.typhimurium contains genes for 3 AHAS isozymes: ilvBN, ilvGM and ilvIH.
messages: Sensitive to valine inhibition.

99287:STM1843
gene id: 99287:STM1843
uniprot id: Q8ZNZ6
names: Subcellular Location Annotation
messages: Membrane

99287:STM3483
gene id: 99287:STM3483
uniprot id: Q8ZLK4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
messages: Cell membrane
messages: Membrane

99287:STM1079
gene id: 99287:STM1079
uniprot id: Q7CQT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HspQ family.
messages: Cytoplasm
messages: Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.

99287:STM0520
gene id: 99287:STM0520
uniprot id: Q8ZR82
names: Subcellular Location Annotation
messages: Membrane

99287:STM4238
gene id: 99287:STM4238
uniprot id: Q8ZKH8
names: Subcellular Location Annotation
messages: Membrane

99287:STM3617
gene id: 99287:STM3617
uniprot id: Q8ZLB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 8 (cellulase D) family.
messages: Hydrolyzes carboxymethylcellulose.
messages: Secreted

99287:STM1281
gene id: 99287:STM1281
uniprot id: Q8ZPW6
names: Subcellular Location Annotation
messages: Membrane

99287:STM2327
gene id: 99287:STM2327
uniprot id: Q7CQ50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

99287:STM2309
gene id: 99287:STM2309
uniprot id: Q8ZNE8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

99287:STM3276
gene id: 99287:STM3276
uniprot id: Q8ZLT8
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

99287:STM3014
gene id: 99287:STM3014
uniprot id: Q7CPV5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM3206
gene id: 99287:STM3206
uniprot id: Q8ZLY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
messages: Homooctamer.

99287:STM1893
gene id: 99287:STM1893
uniprot id: Q8ZNV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

99287:STM4290
gene id: 99287:STM4290
uniprot id: P40862
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
messages: Cell inner membrane
messages: Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response (By similarity).

99287:STM0356
gene id: 99287:STM0356
uniprot id: Q8ZRG4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM2213
gene id: 99287:STM2213
uniprot id: Q8ZNK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxT phosphotransferase family.
messages: Cell inner membrane
messages: Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1-diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P).

99287:STM2583
gene id: 99287:STM2583
uniprot id: P0A1W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

99287:STM3526
gene id: 99287:STM3526
uniprot id: Q8ZLH4
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

99287:STM0229
gene id: 99287:STM0229
uniprot id: Q8ZRN9
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

99287:STM1818
gene id: 99287:STM1818
uniprot id: P63521
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.
messages: Membrane

99287:STM3861
gene id: 99287:STM3861
uniprot id: Q8ZKX1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

99287:STM1195
gene id: 99287:STM1195
uniprot id: P0A2C9
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Calcium ions stabilize the structure, and may inhibit FabG activity by obstructing access to the active site.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

99287:STM3286
gene id: 99287:STM3286
uniprot id: Q9ZF31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).

99287:STM2346
gene id: 99287:STM2346
uniprot id: P65559
names: Similarity
messages: Belongs to the Nudix hydrolase family.

99287:STM2172
gene id: 99287:STM2172
uniprot id: Q7CQ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane
messages: Membrane

99287:STM0800
gene id: 99287:STM0800
uniprot id: Q8ZQQ2
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LRR-containing bacterial E3 ligase family.
messages: Binding to TXN is inhibited by hydrogen peroxide in vitro.
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (thioredoxin). Leads to significant decrease of thioredoxin activity and increase of host cell death.
messages: Host cytoplasm
messages: Interacts with host TXN.
messages: Secreted
messages: The LRR (leucine-rich repeat) domain forms a slightly curved solenoid and may mediate interaction with target proteins.
messages: Ubiquitinated in the presence of host E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme and ubiquitin.

99287:STM1556
gene id: 99287:STM1556
uniprot id: Q8ZPF4
names: Subcellular Location Annotation
messages: Membrane

99287:STM3208
gene id: 99287:STM3208
uniprot id: P40731
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

99287:STM4146
gene id: 99287:STM4146
uniprot id: P0A1H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

99287:STM2301
gene id: 99287:STM2301
uniprot id: O52327
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 83 family.
messages: Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
messages: Cell inner membrane
messages: Induced by BasR.

99287:STM3379
gene id: 99287:STM3379
uniprot id: Q7CPM1
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

99287:STM4335
gene id: 99287:STM4335
uniprot id: Q8ZKB7
names: Similarity
messages: Belongs to the EcnA/EcnB lipoprotein family.

99287:STM3253
gene id: 99287:STM3253
uniprot id: Q7CPQ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase GatY subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol.
messages: Forms a complex with GatZ.

99287:STM0956
gene id: 99287:STM0956
uniprot id: Q8ZQD7
names: Subcellular Location Annotation
messages: Membrane

99287:STM1451
gene id: 99287:STM1451
uniprot id: Q8ZPM7
names: Similarity
messages: Belongs to the GST superfamily.

99287:STM0108
gene id: 99287:STM0108
uniprot id: Q7CR85
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Expression is repressed by thiamine.
messages: Insertions in thiBPQ cause a defect in the transport of both thiamine and TPP.
messages: Part of the ABC transporter complex ThiBPQ involved in thiamine import (PubMed:9535878). Is also involved in thiamine pyrophosphate transport (PubMed:9535878).
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).

99287:STM1151
gene id: 99287:STM1151
uniprot id: Q8ZQ26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. OpgH subfamily.
messages: Cell inner membrane
messages: Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).

99287:STM4022
gene id: 99287:STM4022
uniprot id: Q9L7R9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldolase LacD family.
messages: Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA) (PubMed:33791429). Can also catalyze the reverse reaction (PubMed:33791429).
messages: Homotetramer.

99287:STM1961
gene id: 99287:STM1961
uniprot id: P26609
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

99287:STM1128
gene id: 99287:STM1128
uniprot id: Q8ZQ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

99287:STM2980
gene id: 99287:STM2980
uniprot id: Q7CPW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
messages: Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
messages: Cytoplasm
messages: Monomer.

99287:STM3509
gene id: 99287:STM3509
uniprot id: Q8ZLI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
messages: Cytoplasm
messages: Monomer.
messages: The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.

99287:STM1781
gene id: 99287:STM1781
uniprot id: Q8ZP31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

99287:STM3049
gene id: 99287:STM3049
uniprot id: Q7CPV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

99287:STM1774
gene id: 99287:STM1774
uniprot id: P0A237
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SirB2 family.
messages: Cell inner membrane
messages: Not essential for the ability to invade cultured HeLa cells (the invasive phenotype).
messages: Required for maximal expression of sirC, not required to invade host cells.

99287:STM1940
gene id: 99287:STM1940
uniprot id: Q8ZNU1
names: Similarity
messages: Belongs to the peptidase C40 family.

99287:STM1469
gene id: 99287:STM1469
uniprot id: Q8ZPL7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

99287:STM1971
gene id: 99287:STM1971
uniprot id: P15934
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

99287:STM1935
gene id: 99287:STM1935
uniprot id: Q8ZNU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

99287:STM2909
gene id: 99287:STM2909
uniprot id: P0A1Y0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

99287:STM0821
gene id: 99287:STM0821
uniprot id: Q8ZQN7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the helicase family. DinG subfamily. Type 1 sub-subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA-dependent ATPase and 5'-3' DNA helicase.

99287:STM1543
gene id: 99287:STM1543
uniprot id: Q8ZPG6
names: Subcellular Location Annotation
messages: Membrane

99287:STM1091
gene id: 99287:STM1091
uniprot id: O30916
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatase IpgD/SopB family.
messages: Contains the consensus sequence Cys-X(5)-Arg characteristic of Mg-independent phosphatases.
messages: Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell.
messages: Secreted

99287:STM4018
gene id: 99287:STM4018
uniprot id: Q9L7R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Cell inner membrane
messages: Could be involved in the export of 2,3-dihydroxypropane-1-sulfonate (DHPS).

99287:STM4123
gene id: 99287:STM4123
uniprot id: Q8ZKL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

99287:STM2521
gene id: 99287:STM2521
uniprot id: Q7CQ15
names: Similarity
messages: Belongs to the YfgM family.

99287:STM4173
gene id: 99287:STM4173
uniprot id: P37461
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Cell inner membrane
messages: Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium (By similarity).
messages: Was originally thought to be involved in the regulation of the labile hydrogenase activity.

99287:STM0417
gene id: 99287:STM0417
uniprot id: P66038
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity).
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

99287:STM4411
gene id: 99287:STM4411
uniprot id: Q7CP87
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

99287:STM3224
gene id: 99287:STM3224
uniprot id: Q8ZLX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Cell inner membrane
messages: Has been proposed to be a redox modulator.

99287:STM0815
gene id: 99287:STM0815
uniprot id: Q8ZQP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

99287:STM3248
gene id: 99287:STM3248
uniprot id: Q8ZLV8
names: Function
names: Similarity
messages: Belongs to the HIBADH-related family. 2-hydroxy-3-oxopropionate reductase subfamily.
messages: Catalyzes the reduction of tatronate semialdehyde to D-glycerate.

99287:STM3567
gene id: 99287:STM3567
uniprot id: P17215
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leucine-binding protein family.
messages: Periplasm
messages: This protein is a component of the leucine, isoleucine, valine, threonine transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids.

99287:STM1814
gene id: 99287:STM1814
uniprot id: P65359
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

99287:STM1711
gene id: 99287:STM1711
uniprot id: P66030
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: Homodimer.

99287:STM0887
gene id: 99287:STM0887
uniprot id: Q7CQV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

99287:STM0689
gene id: 99287:STM0689
uniprot id: P0A2G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
messages: Cell inner membrane
messages: Uptake of citrate across the boundary membrane with the concomitant transport of protons into the cell (symport system) (Probable). Allows the utilization of citrate as a sole source of carbon and energy upon expression in E.coli (PubMed:1718953).

99287:STM3328
gene id: 99287:STM3328
uniprot id: Q8ZLR5
names: PTM
names: Subcellular Location Annotation
messages: Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain.
messages: Cell inner membrane
messages: Membrane

99287:STM0090
gene id: 99287:STM0090
uniprot id: Q56016
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

99287:STM2881
gene id: 99287:STM2881
uniprot id: P0CL00
names: Function
names: PTM
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-IacP.
messages: Acyl carrier protein.
messages: Cytoplasm

99287:STM2401
gene id: 99287:STM2401
uniprot id: Q8ZNA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily.
messages: Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(acyl)-lipid IV(A).
messages: Cell inner membrane

99287:STM1723
gene id: 99287:STM1723
uniprot id: P00898
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cooperatively feedback inhibited by tryptophan.
messages: Homodimer. In fact, exists in a monomer-dimer equilibrium in solution, shifted spontaneously in favor of the dimer; the monomer has a reduced activity compared with the dimer. Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE) (Potential).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

99287:STM3437
gene id: 99287:STM3437
uniprot id: P60428
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

99287:STM1684
gene id: 99287:STM1684
uniprot id: Q8ZP64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0283 family.
messages: Cell inner membrane

99287:STM4356
gene id: 99287:STM4356
uniprot id: Q8ZKA7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM1207
gene id: 99287:STM1207
uniprot id: Q8ZQ08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LpoB family.
messages: Cell outer membrane
messages: Interacts with PBP1b.
messages: Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).

99287:STM3005
gene id: 99287:STM3005
uniprot id: Q8ZMA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MutH family.
messages: Cytoplasm
messages: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.

99287:STM3577
gene id: 99287:STM3577
uniprot id: Q02755
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a receptor for citrate and mediates taxis away from phenol. Also mediates an attractant response to metal-citrate complexes.
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane
messages: Methylation level is increased by citrate and decreased by phenol.

99287:STM1304
gene id: 99287:STM1304
uniprot id: Q8ZPV1
names: Function
names: Induction
names: Similarity
messages: Belongs to the arginine N-succinyltransferase family.
messages: By nitrogen and carbon starvation, and arginine, via the ArgR and Crp transcriptional regulators.
messages: Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.

99287:STM1623
gene id: 99287:STM1623
uniprot id: Q8ZPB2
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

99287:STM1386
gene id: 99287:STM1386
uniprot id: Q8ZPP6
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Cell inner membrane
messages: Member of the two-component regulatory system TtrR/TtrS, which is required for synthesis of tetrathionate reductase. Probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue in response to tetrathionate, and transfers its phosphate group to TtrR. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut.
messages: Mutants are defective in tetrathionate respiration.

99287:STM4557
gene id: 99287:STM4557
uniprot id: Q8ZJW5
names: Function
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.

99287:STM0395
gene id: 99287:STM0395
uniprot id: Q8ZRE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. SbcC subfamily.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

99287:STM2501
gene id: 99287:STM2501
uniprot id: O86090
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

99287:STM1920
gene id: 99287:STM1920
uniprot id: P06110
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors.

99287:STM2023
gene id: 99287:STM2023
uniprot id: Q05594
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell inner membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry. Expression of just CbiMN in E.coli confers some cobalt uptake.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity.

99287:STM0705
gene id: 99287:STM0705
uniprot id: Q8ZQW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

99287:STM1370
gene id: 99287:STM1370
uniprot id: Q8ZPQ4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

99287:STM3031
gene id: 99287:STM3031
uniprot id: Q8ZM87
names: Similarity
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpX family.

99287:STM0827
gene id: 99287:STM0827
uniprot id: Q8ZQN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

99287:STM0150
gene id: 99287:STM0150
uniprot id: P0CK99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Cell inner membrane
messages: Permease that is involved in the active transport across the cytoplasmic membrane of all three aromatic amino acids, phenylalanine, tyrosine and tryptophan.

99287:STM3280
gene id: 99287:STM3280
uniprot id: Q8ZLT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

99287:STM0114
gene id: 99287:STM0114
uniprot id: P03062
names: Function
messages: Involved in control of the biosynthesis of leucine.

99287:STM4293
gene id: 99287:STM4293
uniprot id: P36555
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoethanolamine transferase family. EptA subfamily.
messages: Catalyzes the addition of a phosphoethanolamine moiety to the lipid A. The phosphoethanolamine modification is required for resistance to polymyxin.
messages: Cell inner membrane
messages: The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions.

99287:STM3822
gene id: 99287:STM3822
uniprot id: Q8ZKZ7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
messages: Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.

99287:STM1068
gene id: 99287:STM1068
uniprot id: Q8ZQ69
names: Similarity
messages: Belongs to the peptidase S16 family.

99287:STM2961
gene id: 99287:STM2961
uniprot id: Q8ZMD8
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.

99287:STM4265
gene id: 99287:STM4265
uniprot id: Q56143
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters (By similarity).

99287:STM0698
gene id: 99287:STM0698
uniprot id: Q8ZQW9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

99287:STM3042
gene id: 99287:STM3042
uniprot id: P28355
names: Function
names: Similarity
messages: Belongs to the RecJ family.
messages: Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available.

99287:STM2054
gene id: 99287:STM2054
uniprot id: Q9XDM8
names: Biotechnology
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A minor shell protein of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. The isolated BMC shell component protein ratio for J:A:B':B:K:T:U is approximately 15:10:7:6:1:1:2 (PubMed:12923081). Not required for structural integrity of BMCs nor to mitigate propionaldehyde toxicity, may selectively transport specific metabolites (PubMed:21239588). May be involved in electron transport across the BMC shell (Probable). Can be engineered to alter permeability of the BMC shell (PubMed:31674899).
messages: Artificial BMCs can be made in E.coli by expressing pduA-pduB/B'-pduT-pduU-pduN-pduJ-pduK (in this order). Enzymes can be targeted to the BMC, and appear to be encapsulated within it.
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the bacterial microcompartments protein family.
messages: Homotrimerizes to form a pseudohexamer; in wild-type the central triangular pore is probably blocked by the [4Fe-4S] center (PubMed:20870711, PubMed:22654060). Interacts with PduS (By similarity).
messages: No visible effect on BMC morphology. Slight growth impairment on 1,2-propanediol and vitamin B12.
messages: Probably bound by a single Cys residue from each subunit; which protein provides the fourth ligand is unknown.
messages: Removal of the [4Fe-4S] center by mutagenesis and different substitutions of Cys-38 allows an increased growth rate under certain limiting-conditions ('L-40' in PduA, pduQ deletion), strongly suggesting this subunit has acquired the ability to transport 1,2-PD, propionaldehyde and NAD(+)/NADH across the BMC shell.
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
messages: When mutated at 9 positions (construct O3-33 with these mutations; K15A, M67L, N148A, N149L, E156S, E160A, K161Y, R167A, V169L) self-assembles into bodies with 24 subunits, suitable for nanotechnology uses.

99287:STM2537
gene id: 99287:STM2537
uniprot id: Q7CQ14
names: Function
names: Similarity
messages: Belongs to the IscX family.
messages: May function as iron donor in the assembly of iron-sulfur clusters.

99287:STM2445
gene id: 99287:STM2445
uniprot id: P0A2D1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

99287:STM0264
gene id: 99287:STM0264
uniprot id: P0A1G9
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 divalent metal cations. Magnesium or manganese.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contains the editing function and is a proofreading 3'-5' exonuclease (By similarity).
messages: The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore: (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi-beta[4] (By similarity).

99287:STM0177
gene id: 99287:STM0177
uniprot id: Q8ZRR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM4024
gene id: 99287:STM4024
uniprot id: Q7CPC9
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP).

99287:STM2183
gene id: 99287:STM2183
uniprot id: Q8ZNM0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion.
messages: Homodimer.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

99287:STM2471
gene id: 99287:STM2471
uniprot id: P59696
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the IS200/IS605 insertion sequence (IS) element family.
messages: Belongs to the transposase 17 family.
messages: Homodimer.
messages: Transposase responsible for transposition of the IS200 insertion sequence (IS) element. Transposition occurs in 2 main steps, excision from the donor DNA 'top strand' into a single strand circle and its subsequent reinsertion into the DNA target. This increases the copy number of the IS.

99287:STM2952
gene id: 99287:STM2952
uniprot id: P64076
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

99287:STM1057
gene id: 99287:STM1057
uniprot id: Q8ZQ76
names: Similarity
messages: Belongs to the peptidase M1 family.

99287:STM4403
gene id: 99287:STM4403
uniprot id: P26265
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Periplasm
messages: This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate.
messages: Two kinetically distinguishable active sites for the two substrates (2',3'-cyclic nucleotides and 3'-nucleotides) have been identified.

99287:STM1203
gene id: 99287:STM1203
uniprot id: P37439
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
messages: The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration. It can also phosphorylate mannose, methyl alpha-glucoside and 2-deoxy-glucose.

99287:STM2200
gene id: 99287:STM2200
uniprot id: Q8ZNK9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM1090
gene id: 99287:STM1090
uniprot id: O30917
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IpgE/SigE chaperone family.
messages: Cytoplasm
messages: Homodimer or higher-order oligomers.
messages: Molecular chaperone required for SopB/SigD stabilization and secretion.
messages: Transcriptionally regulated by InvF and SicA. Also regulated by SirA.

99287:STM1344
gene id: 99287:STM1344
uniprot id: Q8ZPS6
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Acts as an anti-FlhC(2)FlhD(4) factor by binding to FlhD, decreasing its ability to bind DNA, and thus negatively regulates expression of flagellar class II operons, decreasing motility in nutrient-poor medium. Required for resistance to host phagocyte oxidase. Suppresses killing of macrophages, while promoting resistance to hydrogen peroxide. Data regarding c-di-GMP is controversial; suppresses bacterial c-di-GMP levels (PubMed:15882417) but neither synthesizes nor degrades c-di-GMP (PubMed:19376870).
messages: Belongs to the YdiV family.
messages: Decreased bacterial resistance to hydrogen peroxide and accelerated bacterial killing of macrophages. increased levels of c-di-GMP (PubMed:15882417). Down-regulation of rdar morphology, 50% reduction in CsgD expression, cellulose and curli fimbriae, increased swimming and swarming. Decrease in c-di-GMP levels (PubMed:19376870). Derepresses transcription of flagellar class II operons in nutrient-poor medium.
messages: Has been proposed to be involved in c-di-GMP turnover (PubMed:15882417), but also not be involved in its turnover (PubMed:19376870). Mutagenesis of Glu-29 in the EAL domain suggests if this protein has c-di-GMP phosphdiesterase activity it is not involved in motility regulation (PubMed:21278297). Note that (PubMed:15882417) and (PubMed:19376870) experiments were done in strain 14028, which is not an LT2 derivative.
messages: Induced in nutrient-poor medium (at protein level).
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.
messages: The multicellular rdar morphotype is characterized by the expression of the adhesive extracellular matrix components cellulose and curli fimbriae.

99287:STM2075
gene id: 99287:STM2075
uniprot id: P0A1R4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).

99287:STM4565
gene id: 99287:STM4565
uniprot id: Q8ZJW0
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

99287:STM1895
gene id: 99287:STM1895
uniprot id: P66746
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Forms a double-tetrameric structure around Holliday junction DNA (HJ); the DNA is nearly flattened between the 2 tetramers. Each domain III contacts a single RuvB subunit, 2 on each side of the HJ; forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex which drives branch migration (PubMed:36002576). In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ (Probable).
messages: Has three domains with a flexible linker between the domains II and III, and assumes an 'L' shape (Probable). In the assembled complex, domain III contacts 2 of the RuvB subunits (PubMed:36002576).
messages: In complex with Holliday junction (HJ) DNA, endogenous RuvB or RuvB from S.thermophilus and ATP catalyzes branch migration (PubMed:36002576). Binding of domain III of RuvA to a single subunit of the RuvB hexamer activates the RuvB ATPase 2 subunits away and nucleotide exchange in the adjacent RuvB subunit (PubMed:36002576).
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

99287:STM3919
gene id: 99287:STM3919
uniprot id: O33789
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WzzB/Cld/Rol family.
messages: Cell inner membrane
messages: Modulates the polysaccharide chain length of enterobacterial common antigen (ECA).
messages: Probably part of a complex composed of WzxE, WzyE and WzzE.

99287:STM1359
gene id: 99287:STM1359
uniprot id: Q8ZPR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.

99287:PSLT054
gene id: 99287:PSLT054
uniprot id: Q93GQ6
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

99287:STM4499
gene id: 99287:STM4499
uniprot id: Q8ZK08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family. YeeN subfamily.
messages: Cytoplasm

99287:STM4165
gene id: 99287:STM4165
uniprot id: Q9L9I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rsd/AlgQ family.
messages: Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
messages: Cytoplasm
messages: Interacts with RpoD.

99287:STM3365
gene id: 99287:STM3365
uniprot id: Q7CPM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane
messages: Forms an efflux pump with AaeB.

99287:STM0663
gene id: 99287:STM0663
uniprot id: Q8ZQY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

99287:STM3782
gene id: 99287:STM3782
uniprot id: Q8ZL19
names: Subcellular Location Annotation
messages: Membrane

99287:STM2197
gene id: 99287:STM2197
uniprot id: Q8ZNL2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

99287:STM2052
gene id: 99287:STM2052
uniprot id: Q9XDN0
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An iron-dependent alcohol dehydrogenase required for optimal 1,2-propanediol (1,2-PD) degradation. NAD(+) and NADH are regenerated internally within the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by the PduP and PduQ enzymes, which reduce NAD(+) and oxidize NADH respectively, although there must also be cofactor transport across the BMC.
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Enzyme is oxygen sensitive.
messages: Interacts with PduP, probably via the N-terminus of PduQ.
messages: Loss of NADH-dependent reduction of propionaldehyde in BMCs. BMCs appear to be normal, cells grow more slowly on 1,2-PD with limiting or saturating CN-B12.
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.

99287:STM3854
gene id: 99287:STM3854
uniprot id: P63365
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

99287:STM4285
gene id: 99287:STM4285
uniprot id: Q8ZKE7
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

99287:STM2142
gene id: 99287:STM2142
uniprot id: Q7CQ96
names: Subcellular Location Annotation
messages: Membrane

99287:STM1748
gene id: 99287:STM1748
uniprot id: Q7CQF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

99287:STM2082
gene id: 99287:STM2082
uniprot id: P26406
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Cell inner membrane
messages: Is responsible for transferring galactose-1-phosphate to the lipid precursor undecaprenol phosphate in the first steps of O-polysaccharide biosynthesis.

99287:STM1183
gene id: 99287:STM1183
uniprot id: P0A1J5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

99287:STM1562
gene id: 99287:STM1562
uniprot id: Q7CQI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HdeB family.
messages: Periplasm
messages: Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins.

99287:STM3498
gene id: 99287:STM3498
uniprot id: Q8ZLJ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

99287:STM0322
gene id: 99287:STM0322
uniprot id: P40861
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

99287:STM2806
gene id: 99287:STM2806
uniprot id: Q56109
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

99287:STM3265
gene id: 99287:STM3265
uniprot id: Q8ZLU3
names: Similarity
messages: Belongs to the UPF0102 family.

99287:STM4463
gene id: 99287:STM4463
uniprot id: Q8ZK37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

99287:STM2078
gene id: 99287:STM2078
uniprot id: P10367
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

99287:STM4545
gene id: 99287:STM4545
uniprot id: Q8ZJX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Cell inner membrane
messages: Involved in succinate export with YjjP. Both proteins are required for export.
messages: The transporter is composed of YjjB and YjjP.

99287:STM2090
gene id: 99287:STM2090
uniprot id: P26398
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

99287:STM0661
gene id: 99287:STM0661
uniprot id: Q8ZQY4
names: Function
names: Similarity
messages: Belongs to the IUNH family. RihA subfamily.
messages: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.

99287:STM3086
gene id: 99287:STM3086
uniprot id: P60659
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

99287:STM2038
gene id: 99287:STM2038
uniprot id: P0A1C7
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Artificial BMCs can be made in E.coli by expressing pduA-pduB/B'-pduT-pduU-pduN-pduJ-pduK (in this order). Enzymes can be targeted to the BMC, and appear to be encapsulated within it.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the bacterial microcompartments protein family.
messages: Cells do not make BMCs, diol dehydratase is found in diffuse aggregates near the cell pole; it was later found this a double pduA-pduBB' deletion (PubMed:11844753). A single deletion forms larger than normal BMCs; it is not fully complemented by protein produced from a plasmid (PubMed:21239588, PubMed:27561553). Grows in an interrupted manner on 1,2-PD and vitamin B12; grows for a while then stops, then restarts as toxic propionaldehyde accumulates and then decreases (PubMed:11844753, PubMed:28585808, PubMed:21239588, PubMed:18296526, PubMed:33227310). Increased DNA mutagenesis, showing propionaldehyde is a mutagen (PubMed:18296526). Makes slightly larger BMCs; this phenotype can be rescued by PduA, but PduJ encoded on a plasmid cannot rescue a PduA deletion. When pduJ is cloned in the chromosomal position of pduA it substantially rescues the pduA deletion (PubMed:27561553, PubMed:33227310). Single pduA deletion makes BMCs but a double pduA-pduJ deletion does not (PubMed:33227310).
messages: Homohexamer with a central pore of about 5.6 Angstroms in diameter. The hexamers pack against each other in arrays (PubMed:20870711, PubMed:24747050, Ref.22, PubMed:25713376). Interacts with the N-terminus of PduP which targets PduP to the BMC (PubMed:22927404). Modeling suggests PduC, PduD, PduE, PduL and PduP interact with a cleft formed by the C-terminal segments of 2 adjacent PduA subunits (on the BMC luminal side) in the hexamer (Probable).
messages: One of the major shell proteins of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation (PubMed:11844753, PubMed:21239588) (Probable). At least one of PduA or PduJ is required for BMC assembly; it must be encoded as the first gene in the pdu operon (PubMed:33227310, PubMed:27561553). Not required for structural integrity of BMCs, it is required to mitigate propionaldehyde toxicity (PubMed:21239588). Controls diffusion of 1,2-PD into and propionaldehyde out of the BMC shell; residue 40 is particularly important for pore permeability (PubMed:28585808, PubMed:25713376, PubMed:27561553) (Probable). Overexpression of this protein leads to aberrant filaments that extend the length of the cell, cross the cleavage furrow and impair division. The filaments form nanotubes with a hollow center (PubMed:11844753, PubMed:33227310). The isolated BMC shell component protein ratio for J:A:B':B:K:T:U is approximately 15:10:7:6:1:1:2 (PubMed:12923081). Edge residues (particularly Lys-26) are important for function and assembly of the BMC, and influence array formation by hexamers (PubMed:24747050). Interaction with PduA allows encapsulation of at least PduP in BMCs (PubMed:22927404). Probably also targets PduD to the BMC (Probable). PduA is probably the hub for binding multiple enzymes to the interior of the BMC; modeling suggests PduC, PduD, PduE, PduG, PduL and PduP are targeted to PduA (Probable).
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
messages: The C-terminal 14 residues mediate binding to the N-terminus of PduP, which encapsulates PduP into BMCs.
messages: The first gene in the pdu operon. BMC production is induced by growth on 1,2-PD vitamin B12 medium (PubMed:10498708, PubMed:26283792). No change when grown in the presence of 1,2-PD, ethanolamine and vitamin B12, suggesting it is possible for both the eut and pdu operons to be expressed at the same time (PubMed:26283792).
messages: Upon overexpression and mixing of purified sheets with 2-ethyl-1-hexanol, will form closed shells. Enzymes (tested with endogenous BMC enzyme DDH and the peroxidase activity of cytC) can be encapsulated in the shells; the enzyme is active in the shells. The shells are permeable to a variety of compounds, showing they could be used to make protein based synthetic bioreactors.

99287:STM2367
gene id: 99287:STM2367
uniprot id: Q7CQ40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell inner membrane
messages: Membrane

99287:STM2503
gene id: 99287:STM2503
uniprot id: Q8ZN67
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.
messages: Membrane

99287:STM0013
gene id: 99287:STM0013
uniprot id: P0A1G7
names: Cofactor
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: By heat shock under the control of the HtpR regulatory protein.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity). Necessary for invasion of epithelial cells, secretion of invasion proteins and proliferation within macrophages.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

99287:STM1991
gene id: 99287:STM1991
uniprot id: Q8ZNT1
names: Function
names: Similarity
messages: Belongs to the vsr family.
messages: May nick specific sequences that contain T:G mispairs resulting from m5C-deamination.

99287:STM3257
gene id: 99287:STM3257
uniprot id: Q8ZLV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GatZ/KbaZ family. GatZ subfamily.
messages: Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GatY. When expressed alone, GatZ does not show any aldolase activity. Is involved in the catabolism of galactitol.
messages: Forms a complex with GatY.

99287:STM3463
gene id: 99287:STM3463
uniprot id: P0A2P4
names: Similarity
messages: Belongs to the UPF0270 family.

99287:STM0180
gene id: 99287:STM0180
uniprot id: P65662
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cleavage and activation of PanD is accelerated by PanM.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits (By similarity). Interacts with PanM (PubMed:22497218, PubMed:22782525).
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

99287:STM1927
gene id: 99287:STM1927
uniprot id: Q9RM66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm
messages: Required for resistance to DNA-damaging agents.

99287:STM4408
gene id: 99287:STM4408
uniprot id: Q8ZK71
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

99287:STM3422
gene id: 99287:STM3422
uniprot id: P0A2A7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

99287:STM3582
gene id: 99287:STM3582
uniprot id: Q8ZLE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

99287:STM2310
gene id: 99287:STM2310
uniprot id: Q8ZNE7
names: Function
names: Similarity
messages: Belongs to the isochorismate synthase family.
messages: Catalyzes the conversion of chorismate to isochorismate.

99287:STM0245
gene id: 99287:STM0245
uniprot id: Q8ZRN1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Cell membrane
messages: The MetNIQ system is also to be able to transport the toxic methionine analog alpha-methyl-methionine.
messages: This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system.

99287:STM0052
gene id: 99287:STM0052
uniprot id: Q8ZRY6
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM3227
gene id: 99287:STM3227
uniprot id: Q7CPR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MzrA family.
messages: Cell inner membrane
messages: Interacts with EnvZ.
messages: Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR.

99287:STM0508
gene id: 99287:STM0508
uniprot id: Q8ZR90
names: Subcellular Location Annotation
messages: Membrane

99287:STM0670
gene id: 99287:STM0670
uniprot id: Q9RCI2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

99287:STM3210
gene id: 99287:STM3210
uniprot id: P07362
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Binds two Mg(2+) per subunit.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

99287:STM2857
gene id: 99287:STM2857
uniprot id: Q8ZMI6
names: Similarity
messages: Belongs to the HypD family.

99287:STM3611
gene id: 99287:STM3611
uniprot id: Q8ZLC1
names: Similarity
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.

99287:STM0639
gene id: 99287:STM0639
uniprot id: Q7CQZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

99287:STM1712
gene id: 99287:STM1712
uniprot id: Q8ZP52
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Cells lacking this gene show no phenotype during growth on propionate, acetate, succinate, glycerol and glucose. The acnAB double mutant does not grow on propionate even when supplemented with glutamate and is unable to respire propionate under anaerobic growth conditions.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Also catalyzes the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The (2S,3S)-2-methylcitrate (2-MC) is a very poor substrate (PubMed:11294638). The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity).
messages: Monomer.

99287:STM4434
gene id: 99287:STM4434
uniprot id: Q8ZK49
names: Subcellular Location Annotation
messages: Membrane

99287:STM2879
gene id: 99287:STM2879
uniprot id: P0CL16
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SicP family.
messages: Cytoplasm
messages: Molecular chaperone required for SptP stabilization and secretion.
messages: The structure of the SptP-SicP complex contains four molecules of the chaperone SicP, aligned in a linear fashion and arranged in two sets of tightly bound homodimers that bind two SptP molecules. The SicP homodimers do not interact with each other, but are held together by a molecular interface formed between two SptP molecules. The chaperone-binding domain of SptP does not adopt a globular fold for interaction with SicP. Each SptP molecule is wrapped around by three SicP chaperones (two chaperones from one homodimer and a third one from the opposite homodimer pair). SptP interacts with SicP chaperone dimers mainly through four regions of its chaperone-binding domain.

99287:STM1946
gene id: 99287:STM1946
uniprot id: O66041
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

99287:STM0220
gene id: 99287:STM0220
uniprot id: Q8ZRP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Homodimer.

99287:STM2470
gene id: 99287:STM2470
uniprot id: Q9ZFV7
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probably major component of the bacterial microcompartment (BMC) shell dedicated to ethanolamine degradation. Expression of eutK, eutL, eutM, eutN, eutS (eutSMNLK) in E.coli leads to formation of a single BMC; expression of this protein alone can also form BMCs (which may be less tightly closed than eutSMNLK shells). The 'bent' shape of this subunit is required for integration of cargo proteins into these BMCs (PubMed:22428024). Coexpression of eutQ with eutSMNLK permits E.coli to make cells with more than one mobile BMC, as is usual in vivo (PubMed:27063436). Targets at least 2 proteins (EutC and EutE) to the interior of the BMC (PubMed:22428024, PubMed:27063436, PubMed:27450681). Proteins such as EutS containing circularly permuted BMC domains may play a key role in conferring heterogeneity and flexibility in this BMC (Probable).
messages: Adding an N- or C-terminal His-tag to this protein prevents it forming BMCs (PubMed:27450681). One side of the hexamer is concave and lined by hydrophobic residues, the other side has a slightly protruding, 6-stranded beta-barrel (By similarity).
messages: Artificial BMCs can be made in E.coli by expressing eutK, eutL, eutM, eutN, eutS (eutSMNLK) or eutS alone. Cargo proteins can be targeted to both BMCs; beta-galactosidase (lacZ) was active within the BMC, showing the BMC allows passage of substrate into the interior. This can lead to the development of tailored BMCs for specific metabolic reactions (PubMed:22428024, PubMed:27063436). The addition of eutQ to the eutSMNLK construct results in biogenesis of multiple BMCs (PubMed:27063436).
messages: Bacterial microcompartment
messages: Belongs to the EutS/PduU family.
messages: Expression of the eut operon allows this bacteria to use ethanolamine as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Homohexamer with a central pore; the hexamer is probably bent by about 40 degrees rather that symmetric; bending depends on Gly-39 (Probable). Interacts with the N-terminus of EutC, targeting it to the interior of the BMC (PubMed:22428024, PubMed:27063436, PubMed:27450681). Interacts with the N-terminus of EutE, targeting it to the interior of the BMC (PubMed:27450681).
messages: Not required for aerobic growth on ethanolamine (EA) supplemented with cobalamin (vitamin B12) (PubMed:10464203, PubMed:16291677). A non-polar deletion mutant grows on EA from pH 5.5 to pH 8.0, but does not grow at pH 8.5, releases increased amounts of acetaldehyde on EA plus vitamin B12 (PubMed:16585748).
messages: The ethanolamine (EA) catabolic bacterial microcompartment (BMC) probably concentrates low levels of ethanolamine catabolic enzymes, concentrates volatile reaction intermediates, keeps the level of toxic acetaldehyde low, generates enough acetyl-CoA to support cell growth, and maintains a pool of free coenzyme A (CoA) and NAD.
messages: The first gene of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12) (PubMed:3045078). Expressed at low levels following mouse infection, not induced in infected macrophages or in spleen (PubMed:26565973).
messages: The need for a bacterial microcompartment in EA metabolism can be bypassed by increasing the levels of EAL and an acetaldehyde dehydrogenase (not necessarily EutE).

99287:STM3323
gene id: 99287:STM3323
uniprot id: Q8ZLR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RapZ-like family. RapZ subfamily.
messages: Homotrimer.
messages: Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.

99287:STM1235
gene id: 99287:STM1235
uniprot id: Q8ZPZ3
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudJ subfamily.
messages: Monomer.

99287:STM2770
gene id: 99287:STM2770
uniprot id: P52619
names: Function
messages: Transcriptional repressor of the FliC phase-1 flagellin.

99287:STM0634
gene id: 99287:STM0634
uniprot id: Q7CQZ4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM2105
gene id: 99287:STM2105
uniprot id: P26340
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.
messages: Involved in the biosynthesis of the capsular polysaccharide colanic acid.

99287:STM1778
gene id: 99287:STM1778
uniprot id: P30752
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Monomer.
messages: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
messages: Was originally thought to be involved in delta-aminolevulinic acid biosynthesis.

99287:STM2356
gene id: 99287:STM2356
uniprot id: P0A245
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.

99287:STM3148
gene id: 99287:STM3148
uniprot id: Q8ZM15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

99287:STM1906
gene id: 99287:STM1906
uniprot id: Q8ZNV1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Deletion results in tRNA having 5-hydroxyuridine (ho5U34) instead of cmo5U34.
messages: Homotetramer.

99287:STM1768
gene id: 99287:STM1768
uniprot id: Q8ZP33
names: Similarity
messages: Belongs to the intimin/invasin family.

99287:STM3033
gene id: 99287:STM3033
uniprot id: Q8ZM86
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the PINc/VapC protein family.
messages: Ectopic overexpression in E.coli induces the YoeB toxin, but this is not the cause of VapC toxicity.
messages: Forms a complex with antitoxin VapB.
messages: Induced by amino acid starvation and by chloramphenicol treatment.
messages: Toxic component of a type II toxin-antitoxin (TA) system. A site-specific tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Does not cleave tRNA(Met), tRNA(Arg2), tRNA(His), tRNA(Leu), tRNA(Phe) tRNA(Thr1), tRNA(Tyr) or tRNA(Val). Overexpression in E.coli inhibits translation, leads to loss of cell growth and degradation of tRNA(fMet), these effects are neutralized by expression of cognate antitoxin VapB. Expression also activates translation initiation at correctly positioned elongator codons (AAA and to a lesser extent AAG).

99287:STM1303
gene id: 99287:STM1303
uniprot id: Q8ZPV2
names: Function
names: Induction
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily.
messages: By nitrogen and carbon starvation, and arginine, via the ArgR and Crp transcriptional regulators.
messages: Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase.

99287:STM2186
gene id: 99287:STM2186
uniprot id: Q8ZNL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NADH dehydrogenase family.
messages: Heterotetramer of 2 PreA and 2 PreT subunits.
messages: Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT) (By similarity).

99287:STM3537
gene id: 99287:STM3537
uniprot id: Q8ZLG6
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin.

99287:STM0804
gene id: 99287:STM0804
uniprot id: Q8ZQQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

99287:STM3368
gene id: 99287:STM3368
uniprot id: Q7CPM5
names: Function
names: Similarity
messages: Belongs to the peptidase U62 family.
messages: Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA).

99287:STM0638
gene id: 99287:STM0638
uniprot id: Q8ZR01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

99287:STM0476
gene id: 99287:STM0476
uniprot id: Q8ZRA6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

99287:STM0711
gene id: 99287:STM0711
uniprot id: P67270
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides.
messages: Toroid-shaped homohexamer. In the hexamer, 3 dimers assemble to form a ring-like structure surrounding a central hole.

99287:STM0608
gene id: 99287:STM0608
uniprot id: P0A251
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer; disulfide-linked, upon oxidation (PubMed:2643600, PubMed:8555198). 5 homodimers assemble to form a ring-like decamer (PubMed:11969410).
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by AhpF.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

99287:STM3232
gene id: 99287:STM3232
uniprot id: Q8ZLW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

99287:STM2140
gene id: 99287:STM2140
uniprot id: Q8ZNP1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
messages: Binds 1 Mg(2+) ion per subunit. Ca(2+) may be able to substitute. 2 Ca(2+) ions are seen in the crystal structure; one of the two occupies the same site as Mg(2+) in other family members.
messages: Homodimer. May interact with the periplasmic chaperone Skp (also known as OmpH); this suggests the protein may be translocated to the periplasm and then sorted to the outer membrane.
messages: In vitro does not phosphorylate diacylglycerol, sphingosine, N,N-dimethylsphingosine; threo-dihydrosphingosine, erythro-dihydrosphingosine, C2 ceramide, C6 ceramide, phosphatidylinositol or dimethylsphingosine. The potential in vivo substrate is unknown.

99287:STM2548
gene id: 99287:STM2548
uniprot id: P26474
names: Cofactor
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: By sulfite. Repressed by oxygen.
messages: Cytoplasm
messages: Electron transfer protein for anaerobic sulfite reductase subunit A.
messages: The anaerobic sulfite reductase seems to consist of three subunits.

99287:STM2850
gene id: 99287:STM2850
uniprot id: Q8ZMI9
names: Subcellular Location Annotation
messages: Membrane

99287:STM0774
gene id: 99287:STM0774
uniprot id: P22713
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

99287:STM1468
gene id: 99287:STM1468
uniprot id: P40720
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80% of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso-tartrate. Can also catalyze the isomerization of enol- to keto-oxaloacetate.
messages: Homodimer.
messages: Is expressed under aerobic conditions. Is repressed by glucose and anaerobiosis.

99287:STM2874
gene id: 99287:STM2874
uniprot id: P41783
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Required for invasion of epithelial cells.

99287:STM0765
gene id: 99287:STM0765
uniprot id: Q8ZQS7
names: Subcellular Location Annotation
messages: Membrane

99287:STM4283
gene id: 99287:STM4283
uniprot id: Q8ZKE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily.
messages: Catalyzes the proton-dependent transport of glutamate and aspartate.
messages: Cell inner membrane
messages: Membrane

99287:STM2164
gene id: 99287:STM2164
uniprot id: Q8ZNM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

99287:STM3468
gene id: 99287:STM3468
uniprot id: P40732
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited by gabaculine (Gcn).
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: The reaction catalyzed by ACOAT is highly reversible. This enzyme may also transaminate ornithine.

99287:STM2207
gene id: 99287:STM2207
uniprot id: P33027
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Set transporter family.
messages: Cell inner membrane
messages: Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose (By similarity).

99287:STM4530
gene id: 99287:STM4530
uniprot id: Q8ZJY6
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

99287:STM0168
gene id: 99287:STM0168
uniprot id: Q8ZRS2
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Binds 4 Cu cations per monomer.
messages: By CueR, at increased levels of cytoplasmic cuprous ions.
messages: Monomer.
messages: Multicopper oxidase involved in copper homeostasis and copper tolerance under both aerobic and anaerobic conditions (PubMed:12442888, PubMed:17768242). Is responsible for the oxidation of Cu(+) to the less harmful Cu(2+) in the periplasm, thereby preventing Cu(+) from entering the cytoplasm (By similarity).
messages: Mutant is very sensitive to copper after copper shock (PubMed:12442888). Causes a moderate defect in aerobic growth on CuSO(4), strongly impairs survival during anaerobic growth on CuSO(4) (PubMed:17768242).
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

99287:STM2196
gene id: 99287:STM2196
uniprot id: Q8ZNL3
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

99287:STM1580
gene id: 99287:STM1580
uniprot id: Q8ZPD8
names: Subcellular Location Annotation
messages: Membrane

99287:STM1071
gene id: 99287:STM1071
uniprot id: P0A241
names: Function
names: Induction
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the SulA family.
messages: By DNA damage, as part of the SOS response.
messages: Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
messages: Interacts with FtsZ.
messages: Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired.

99287:STM4374
gene id: 99287:STM4374
uniprot id: Q8ZK97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

99287:STM2396
gene id: 99287:STM2396
uniprot id: P06184
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. When activated by PgtB it acts in conjunction with sigma-54 as a transcriptional activator.
messages: Phosphorylated by PgtB.

99287:STM4533
gene id: 99287:STM4533
uniprot id: Q8ZJY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane
messages: Membrane

99287:STM2575
gene id: 99287:STM2575
uniprot id: Q8ZN21
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM2042
gene id: 99287:STM2042
uniprot id: O31042
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A triple pduC-pduD-pduE deletion releases no acetaldehyde when grown on propanediol.
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium (PubMed:10498708). By either propanediol or glycerol.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the diol/glycerol dehydratase small subunit family.
messages: Inhibited by glycerol.
messages: Part of the PduCDE complex that catalyzes the dehydration of 1,2-propanediol (1,2-PD) to propionaldehyde. Required for S.typhimurium growth on 1,2-PD as the sole carbon and energy source. Localized in the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation.
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
messages: The propanediol dehydratase enzyme is a heterotrimeric complex composed of a large (PduC), a medium (PduD) and a small (PduE) subunit.

99287:STM1440
gene id: 99287:STM1440
uniprot id: O68901
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Monomer.
messages: Periplasm

99287:STM0870
gene id: 99287:STM0870
uniprot id: Q8ZQK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.
messages: Cell membrane

99287:STM0306
gene id: 99287:STM0306
uniprot id: Q8ZRJ9
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
messages: All four putative extracellular loops are crucial for invasion of mammalian cells.
messages: Cell outer membrane
messages: Haemagglutinin that facilitates the adhesion to and invasion of epithelial mammalian cells. Utilizes heparinated proteoglycan as a receptor to successfully invade host cells.
messages: Induced by both low pH and low Mg(2+) via the PhoQ/PhoP two-component regulatory system. Responds to general intracellular signals that are present both in initial and in progressive stages of infection.

99287:STM2169
gene id: 99287:STM2169
uniprot id: Q7CQ88
names: Subcellular Location Annotation
messages: Membrane

99287:STM1070
gene id: 99287:STM1070
uniprot id: P02936
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
messages: Cell outer membrane
messages: Monomer and homodimer.
messages: Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells.
messages: The extracellular loops are most variable in sequence, and in some bacteria confer sensitivity to phage and/or colicins.
messages: With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.

99287:STM2451
gene id: 99287:STM2451
uniprot id: P33771
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

99287:STM1166
gene id: 99287:STM1166
uniprot id: Q8ZQ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
messages: Cell inner membrane

99287:STM1523
gene id: 99287:STM1523
uniprot id: Q8ZPI4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM2091
gene id: 99287:STM2091
uniprot id: P26397
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

99287:STM4585
gene id: 99287:STM4585
uniprot id: Q8ZJU8
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. GpmB subfamily.

99287:STM2892
gene id: 99287:STM2892
uniprot id: P40613
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SpaN family.
messages: Cytoplasm
messages: Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.

99287:STM3010
gene id: 99287:STM3010
uniprot id: Q8ZMA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
messages: In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.
messages: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.

99287:STM1705
gene id: 99287:STM1705
uniprot id: P37723
names: Function
names: Induction
names: Subcellular Location Annotation
messages: By elevated osmotic pressure in the growth medium.
messages: Cell membrane
messages: Provides resistance to osmotic stress. May be important for stationary-phase survival (By similarity).

99287:STM4027
gene id: 99287:STM4027
uniprot id: Q8ZKT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0761 family.
messages: Cell inner membrane

99287:STM1784
gene id: 99287:STM1784
uniprot id: Q7CQE8
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

99287:STM2681
gene id: 99287:STM2681
uniprot id: Q7CPZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

99287:STM4102
gene id: 99287:STM4102
uniprot id: Q8ZKN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

99287:STM0006
gene id: 99287:STM0006
uniprot id: Q8ZS16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

99287:STM0835
gene id: 99287:STM0835
uniprot id: P67710
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.
messages: In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP (By similarity).
messages: It contains an N-terminal DNA-binding domain and a metal-binding domain.

99287:STM1418
gene id: 99287:STM1418
uniprot id: P74860
names: Function
names: Similarity
messages: Belongs to the FliN/MopA/SpaO family.
messages: Part of a type III secretion system.

99287:STM0951
gene id: 99287:STM0951
uniprot id: Q8ZQD9
names: Similarity
messages: Belongs to the pirin family.

99287:STM0684
gene id: 99287:STM0684
uniprot id: Q8ZQX7
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Homohexamer.

99287:STM3326
gene id: 99287:STM3326
uniprot id: Q8ZLR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

99287:STM1495
gene id: 99287:STM1495
uniprot id: Q8ZPK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TorD/DmsD family. DmsD subfamily.
messages: Monomer in solution.
messages: Required for biogenesis/assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding-maturation pathway for the substrate protein.

99287:STM3032
gene id: 99287:STM3032
uniprot id: P59696
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the IS200/IS605 insertion sequence (IS) element family.
messages: Belongs to the transposase 17 family.
messages: Homodimer.
messages: Transposase responsible for transposition of the IS200 insertion sequence (IS) element. Transposition occurs in 2 main steps, excision from the donor DNA 'top strand' into a single strand circle and its subsequent reinsertion into the DNA target. This increases the copy number of the IS.

99287:STM3738
gene id: 99287:STM3738
uniprot id: Q8ZL43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

99287:STM1677
gene id: 99287:STM1677
uniprot id: Q8ZP70
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM1783
gene id: 99287:STM1783
uniprot id: P0A281
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Involved in lambda inhibition of host protein synthesis. PTH activity may, directly or indirectly, be the target for lambda bar RNA leading to rap cell death (By similarity).

99287:STM2967
gene id: 99287:STM2967
uniprot id: P60084
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Syd family.
messages: Cell inner membrane
messages: Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.

99287:STM0687
gene id: 99287:STM0687
uniprot id: Q7CQY4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.
messages: Cell outer membrane
messages: In the absence of chitobiose, expression of chiPQ is silenced by the ChiX small regulatory RNA (sRNA), which sequesters the ribosome binding site of the chiPQ mRNA by an antisense mechanism. In the presence of chitosugars, the chbBCARFG chitobiose operon is induced and acts as an RNA trap to degrade the constitutively expressed ChiX, leading to the translation of chiPQ. Chitobiose and chitotriose also induce chiP mRNA synthesis.
messages: Involved in the uptake of chitosugars.

99287:STM2395
gene id: 99287:STM2395
uniprot id: P06185
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A26 family.
messages: Cell outer membrane
messages: Protease that can cleave T7 RNA polymerase. Specific for paired basic residues.

99287:STM0710
gene id: 99287:STM0710
uniprot id: Q7CQY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpD subfamily.
messages: Cell inner membrane
messages: Probable proton-dependent permease that transports dipeptides.

99287:STM0021
gene id: 99287:STM0021
uniprot id: H9L412
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM4234
gene id: 99287:STM4234
uniprot id: Q7CPB4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: A mutant in which deletion of the last 50 residues is combined with the 'Tyr-56' mutation in rsmG is highly resistant to streptomycin and has a small colony phenotype (which grow slowly and are resistant to aminoglycoside anitbiotics).
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

99287:STM1147
gene id: 99287:STM1147
uniprot id: P67341
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YmdB family.
messages: Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
messages: Homodimer. Interacts with RNase III.

99287:STM1334
gene id: 99287:STM1334
uniprot id: P33321
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

99287:STM3011
gene id: 99287:STM3011
uniprot id: P0CL11
names: Function
names: Subunit
messages: Homodimer.
messages: Repressor of the galactose operon. Binds galactose as an inducer (By similarity).

99287:STM0492
gene id: 99287:STM0492
uniprot id: Q8ZR99
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

99287:STM3880
gene id: 99287:STM3880
uniprot id: Q8ZKW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell inner membrane
messages: Responsible for the low-affinity transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

99287:STM2061
gene id: 99287:STM2061
uniprot id: P0A212
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA gyrase inhibitor family.
messages: Cytoplasm
messages: Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
messages: Interacts with DNA gyrase.

99287:STM3336
gene id: 99287:STM3336
uniprot id: Q8ZLQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ROK (NagC/XylR) family. NanK subfamily.
messages: Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
messages: Homodimer.

99287:STM2789
gene id: 99287:STM2789
uniprot id: P0CL02
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
messages: Belongs to the glutarate hydroxylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Homotetramer.

99287:STM0589
gene id: 99287:STM0589
uniprot id: Q8ZR36
names: Subcellular Location Annotation
messages: Membrane

99287:STM3104
gene id: 99287:STM3104
uniprot id: Q8ZM44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

99287:STM0942
gene id: 99287:STM0942
uniprot id: Q8ZQE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
messages: Cell inner membrane
messages: Homodimer. Part of the tripartite efflux system MacAB-TolC, which is composed of an inner membrane transporter, MacB, a periplasmic membrane fusion protein, MacA, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. Interacts with MacA.
messages: Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.

99287:STM3620
gene id: 99287:STM3620
uniprot id: Q8ZLB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BcsQ family.
messages: Cytoplasm
messages: Essential for cellulose biosynthesis. May play a role in subcellular localization of an active cellulose biosynthesis apparatus at the bacterial cell pole (By similarity).

99287:STM1302
gene id: 99287:STM1302
uniprot id: P0A1A9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities (By similarity).
messages: Monomer.
messages: Probably binds two magnesium or manganese ions per subunit.

99287:STM3819
gene id: 99287:STM3819
uniprot id: Q8ZKZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).

99287:STM2103
gene id: 99287:STM2103
uniprot id: H9L490
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

99287:STM1826
gene id: 99287:STM1826
uniprot id: Q8ZP07
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

99287:STM0805
gene id: 99287:STM0805
uniprot id: Q8ZQQ0
names: Similarity
messages: Belongs to the MoaD family.

99287:STM0194
gene id: 99287:STM0194
uniprot id: O87656
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane (By similarity). Involved in ferrioxamine-mediated iron(III) utilization (PubMed:10103258).
messages: The complex is composed of two ATP-binding proteins (FhuC), a transmembrane protein (FhuB) and a solute-binding protein (FhuD).

99287:STM1970
gene id: 99287:STM1970
uniprot id: P0A1J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).

99287:STM3928
gene id: 99287:STM3928
uniprot id: P37458
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WzyE family.
messages: Cell inner membrane
messages: Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.
messages: Probably part of a complex composed of WzxE, WzyE and WzzE.
messages: Was originally thought to be WecF, the 4-alpha-L-fucosyltransferase.

99287:STM4311
gene id: 99287:STM4311
uniprot id: P59696
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the IS200/IS605 insertion sequence (IS) element family.
messages: Belongs to the transposase 17 family.
messages: Homodimer.
messages: Transposase responsible for transposition of the IS200 insertion sequence (IS) element. Transposition occurs in 2 main steps, excision from the donor DNA 'top strand' into a single strand circle and its subsequent reinsertion into the DNA target. This increases the copy number of the IS.

99287:STM4578
gene id: 99287:STM4578
uniprot id: Q7CP65
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

99287:STM3390
gene id: 99287:STM3390
uniprot id: Q8ZLN5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

99287:STM1899
gene id: 99287:STM1899
uniprot id: P67179
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

99287:STM3470
gene id: 99287:STM3470
uniprot id: P20751
names: Function
names: Similarity
messages: Belongs to the fic family.
messages: Involved in cell filamentation induced by cyclic AMP.
messages: Probable adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (By similarity). Involved in cell filamentation induced by cyclic AMP.

99287:STM3734
gene id: 99287:STM3734
uniprot id: P0A2C3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
messages: Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates.

99287:STM0103
gene id: 99287:STM0103
uniprot id: P06188
names: Similarity
messages: Belongs to the ribulokinase family.

99287:STM1582
gene id: 99287:STM1582
uniprot id: Q00267
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arylamine N-acetyltransferase family.
messages: Catalyzes both the acetyl-CoA-dependent N-acetylation of aromatic amines and the O-acetylation of N-hydroxyarylamines. In vitro, catalyzes the O-acetylation of N-hydroxy-Glu-P-1, and the N-acetylation of isoniazid and 2-aminofluorene.
messages: Cytoplasm
messages: Inhibited by N-ethylmaleimide and iodoacetamide.
messages: Monomer and homodimer.

99287:STM2201
gene id: 99287:STM2201
uniprot id: Q8ZNK8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM3628
gene id: 99287:STM3628
uniprot id: Q8ZLB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

99287:STM2019
gene id: 99287:STM2019
uniprot id: Q05597
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Homodimer.

99287:STM2499
gene id: 99287:STM2499
uniprot id: P74883
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

99287:STM1805
gene id: 99287:STM1805
uniprot id: Q8ZP15
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes. Binding of FadR is specifically inhibited by long chain fatty acyl-CoA compounds (By similarity).

99287:STM0977
gene id: 99287:STM0977
uniprot id: P55900
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.

99287:STM4562
gene id: 99287:STM4562
uniprot id: Q7CP67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0391 family.
messages: Cell membrane

99287:STM0182
gene id: 99287:STM0182
uniprot id: Q8ZRR0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

99287:STM0248
gene id: 99287:STM0248
uniprot id: Q8ZRM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GmhB family.
messages: Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.
messages: Cytoplasm
messages: Monomer.

99287:STM4193
gene id: 99287:STM4193
uniprot id: Q8ZKL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine synthase RsuA family.
messages: Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-2604 in 23S ribosomal RNA and from uracil-35 in the anticodon of tRNA(Tyr).
messages: Monomer.

99287:STM3704
gene id: 99287:STM3704
uniprot id: Q8ZL56
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

99287:STM2686
gene id: 99287:STM2686
uniprot id: P0A2L7
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

99287:STM1074
gene id: 99287:STM1074
uniprot id: Q7CQT3
names: Subcellular Location Annotation
messages: Cell inner membrane

99287:STM3161
gene id: 99287:STM3161
uniprot id: P18949
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family.
messages: Catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis.
messages: Cytoplasm
messages: Homotetramer.

99287:STM0593
gene id: 99287:STM0593
uniprot id: Q8ZR35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family.
messages: Cell inner membrane
messages: Component of an export pathway for enterobactin.

99287:STM3683
gene id: 99287:STM3683
uniprot id: Q8ZL69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers. Binds only one seryl-tRNA(Sec) per dimer.

99287:STM0448
gene id: 99287:STM0448
uniprot id: P0A1D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. Component of the ClpAP and ClpXP complexes.

99287:STM1471
gene id: 99287:STM1471
uniprot id: Q8ZPL6
names: Subcellular Location Annotation
messages: Cell inner membrane

99287:STM3690
gene id: 99287:STM3690
uniprot id: Q8ZL65
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homotrimer.
messages: Required for proper surface expression of the autotransporter adhesin SadA. Could be directly involved in the biogenesis of functionally active SadA.
messages: The homotrimer is held together by an extended N-terminal coiled coil, which leads into three separate globular C-terminal domains of beta-sandwich topology.

99287:STM1929
gene id: 99287:STM1929
uniprot id: P0CL50
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

99287:STM1398
gene id: 99287:STM1398
uniprot id: Q7BVH7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EspA/SseB family.
messages: Cell surface
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. May act as a translocator that mediates translocation of SPI-2 T3SS effector proteins from intraphagosomal bacterial cells into the host cells. SseB is required for correct localization of SseC and SseD on the bacterial cell surface.
messages: May form a complex with SseC and SseD. Binds to the chaperone SseA.
messages: Mutant is severely attenuated in virulence. Disruption prevents SpvB-induced F-actin depolymerization in human macrophages without affecting intra-bacterial SpvB protein levels.
messages: Secreted

99287:STM1274
gene id: 99287:STM1274
uniprot id: Q7CQP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

99287:STM3798
gene id: 99287:STM3798
uniprot id: Q8ZL12
names: Subcellular Location Annotation
messages: Membrane

99287:STM4383
gene id: 99287:STM4383
uniprot id: Q8ZK90
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UlaA family.
messages: Cell inner membrane
messages: Homodimer.
messages: In classical PTS systems, the PTS EIIC type-2 domain forms the translocation channel and contains the specific substrate-binding site. UlaA does not exhibit the topological features of any recognized enzyme IIC.
messages: Induced by L-ascorbate. Repressed by UlaR.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.

99287:STM1652
gene id: 99287:STM1652
uniprot id: P67091
names: Similarity
names: Subunit
messages: Belongs to the universal stress protein A family.
messages: Homodimer.

99287:STM3550
gene id: 99287:STM3550
uniprot id: Q7CPK1
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM0802
gene id: 99287:STM0802
uniprot id: P65386
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

99287:STM2988
gene id: 99287:STM2988
uniprot id: Q8ZMC0
names: Function
messages: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.

99287:STM3209
gene id: 99287:STM3209
uniprot id: P68684
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

99287:STM3421
gene id: 99287:STM3421
uniprot id: P66073
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

99287:STM1659
gene id: 99287:STM1659
uniprot id: P0A2U0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

99287:STM2640
gene id: 99287:STM2640
uniprot id: P0A2F0
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. ECF subfamily.
messages: Cytoplasm
messages: ECF sigma-E is held in an inactive form by its cognate anti-sigma factor (RseA) until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal (periplasmic stress and excess LPS) triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The anti-sigma factor RseA is an inner membrane protein, binding sigma-E in the cytoplasm and RseB in the periplasm. RseA is first cut extracytoplasmically (site-1 protease, S1P, by DegS), then within the membrane itself (site-2 protease, S2P, by RseP), while cytoplasmic proteases (predominantly ClpX-ClpP) finish degrading the regulatory protein, liberating sigma-E. Degradation of RseA requires 2 signals to activate DegS; an outer membrane protein (OMP) signal activates DegS, while an LPS signal causes release of RseB from RseA, freeing RseA to be cleaved (By similarity).
messages: Interacts transiently with the RNAP catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNAP holoenzyme that can initiate transcription. Interacts 1:1 with anti-sigma-E factor RseA which prevents binding to RNAP catalytic core (By similarity).
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as acid stress, heat shock and oxidative stress; it controls protein processing in the extracytoplasmic compartment (By similarity).
messages: The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain-2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity).
messages: The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA. Interactions between sigma-70 factor domain-4 and anti-sigma factors prevents interaction of sigma factors with the RNA polymerase catalytic core (By similarity).

99287:STM1815
gene id: 99287:STM1815
uniprot id: Q8ZP10
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

99287:STM4526
gene id: 99287:STM4526
uniprot id: Q8ZJY8
names: Similarity
messages: Belongs to the HsdR family.

99287:STM4524
gene id: 99287:STM4524
uniprot id: P06187
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the type-I restriction system S methylase family.
messages: Contains two DNA recognition domains, each specifying recognition of one of the two defined components of the target sequence (PubMed:3025838, PubMed:2838725). The recognition domains can be exchanged between different S proteins, generating enzymes that have new sequence specificities (PubMed:2838725).
messages: The specificity (S) subunit of a type I restriction enzyme; this subunit dictates DNA sequence specificity. The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues of the sequence 5'-GAGN(6)GTRC-3'. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated (PubMed:3025838, PubMed:12654995). After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage (By similarity).
messages: The type I restriction/modification system is composed of three polypeptides R, M and S; the restriction enzyme has stoichiometry R(2)M(2)S(1) while the methyltransferase is M(2)S(1).
messages: Type I restriction and modification enzymes are complex, multifunctional systems which require ATP, S-adenosyl methionine and Mg(2+) as cofactors and, in addition to their endonucleolytic and methylase activities, are potent DNA-dependent ATPases.

99287:STM2280
gene id: 99287:STM2280
uniprot id: Q8XEK9
names: Subcellular Location Annotation
messages: Membrane

99287:STM3430
gene id: 99287:STM3430
uniprot id: Q7CPL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

99287:STM2404
gene id: 99287:STM2404
uniprot id: Q93IM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Cell membrane

99287:STM0206
gene id: 99287:STM0206
uniprot id: Q8ZRP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BtuF family.
messages: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity).
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).

99287:STM4154
gene id: 99287:STM4154
uniprot id: P0A2R4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Chromosomal supercoiling density is controlled by a combination of RNA polymerase and DNA gyrase activity; negative supercoiling increases upstream of transcribed regions while it decreases downstream, DNA gyrase introduces negative supercoils into underwound DNA (PubMed:22916023).
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

99287:STM0170
gene id: 99287:STM0170
uniprot id: O33799
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm
messages: Homotetramer.
messages: Purine salvage pathway enzyme which catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of hypoxanthine to yield IMP (inosine 5'-monophosphate). To a lesser extent, can also act on guanine leading to GMP, but shows a highly less efficient activity with xanthine.

99287:STM3295
gene id: 99287:STM3295
uniprot id: Q8ZLS8
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

99287:STM2884
gene id: 99287:STM2884
uniprot id: P0CL47
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SctB/SipC family.
messages: Component of the type III secretion system 1 (SPI-1 T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:23544147). SipB/SctE1 and SipC/SctB1 are inserted into the host membrane where they form a pore and allow the translocation of effector proteins into the cytosol of target cells (PubMed:23544147).
messages: Host membrane
messages: Mediates the intimate attachment to target host cells (PubMed:19364837). Actin-binding protein that interferes with host cell actin cytoskeleton (PubMed:10487745, PubMed:11331579). Nucleates actin polymerization and condensates actin filaments into cables (bundling) (PubMed:10487745, PubMed:11331579). SipA potentiates SipC/SctB1 activity and both are required for an efficient bacterial internalization by the host cell (PubMed:11331579).
messages: Mutant can assemble a fully functional needle complex and can secrete (but cannot translocate) all proteins traveling the SPI-1 T3SS pathway, but the mutant is defective for intimate attachment (PubMed:19364837). Mutants that no longer interact with SipB/SctE1 are defective in translocon assembly in the host membrane (PubMed:23544147).
messages: Secreted
messages: The N-terminal region (SipC-N, 1-120) induces actin bundling (PubMed:10487745). The C-terminal region (SipC-C, 200-409) nucleates actin polymerization from barbed ends and enhances SipC-N induced actin bundling (PubMed:10487745). The C-terminal region (340-409) is required for SipB/SctE1-SipC/SctB1 complex formation (PubMed:23544147).
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569). This subunit is involved in the formation of a pore, called the translocon, in host membrane (PubMed:23544147). Interacts with SipB/SctE1 (PubMed:23544147).

99287:STM0219
gene id: 99287:STM0219
uniprot id: P66738
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

99287:STM4119
gene id: 99287:STM4119
uniprot id: Q8ZKM0
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.
messages: The enzyme has distinct binding sites for each of the allosteric effectors such as acetyl-CoA, fructose 1,6-bisphosphate, guanosine 3'-diphosphate 5'-diphosphate, long chain fatty acids, and L-aspartate.

99287:STM1655
gene id: 99287:STM1655
uniprot id: Q8ZP87
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DbpA subfamily.
messages: Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.

99287:STM3996
gene id: 99287:STM3996
uniprot id: Q8ZKU8
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A protein kinase that (auto)phosphorylates on Ser and Thr residues, probably involved in the extracytoplasmic stress response (PubMed:12511488). Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species (By similarity).
messages: Belongs to the SrkA/RdoA protein kinase family.
messages: Cytoplasm
messages: Decreases long-term survival (1000-fold decrease after 20 days in liquid culture), derepresses curli production under non-curli-inducing growth conditions.
messages: Expression is growth phase dependent and sensitive to the media conditions reaching high levels in stationary phase (at protein level) (PubMed:17302814). It is probably regulated by the CpxRA two-component regulatory system (PubMed:12511488).
messages: Monomer.

99287:STM2098
gene id: 99287:STM2098
uniprot id: P0A2K7
names: Function
names: Similarity
messages: Belongs to the UDPGP type 2 family.
messages: May play a role in stationary phase survival.

99287:STM4431
gene id: 99287:STM4431
uniprot id: Q8ZK52
names: Similarity
messages: Belongs to the TPP enzyme family.

99287:PSLT053
gene id: 99287:PSLT053
uniprot id: Q93GQ7
names: Similarity
messages: Belongs to the ParB family.

99287:STM0069
gene id: 99287:STM0069
uniprot id: Q8ZRX6
names: Function
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.
messages: Overproduction of CaiE stimulates the activity of CaiB and CaiD.

99287:STM4237
gene id: 99287:STM4237
uniprot id: P0A273
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

99287:STM1764
gene id: 99287:STM1764
uniprot id: Q8ZP37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

99287:STM2391
gene id: 99287:STM2391
uniprot id: Q8ZNA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Involved in translocation of long-chain fatty acids across the outer membrane. FadL may form a specific channel (By similarity).

99287:STM4477
gene id: 99287:STM4477
uniprot id: Q8ZK29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

99287:STM3843
gene id: 99287:STM3843
uniprot id: Q8ZKY3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

99287:STM2984
gene id: 99287:STM2984
uniprot id: Q8ZMC3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

99287:STM1753
gene id: 99287:STM1753
uniprot id: Q7CQF1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the RssB family.
messages: Binds to RpoS.
messages: Phosphorylated. Phosphorylation stimulates the interaction with RpoS and, therefore, the proteolysis of RpoS.
messages: Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co-degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation.

99287:STM1787
gene id: 99287:STM1787
uniprot id: Q8ZP27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

99287:STM1811
gene id: 99287:STM1811
uniprot id: Q8ZP12
names: Similarity
messages: Belongs to the UPF0260 family.

99287:STM2057
gene id: 99287:STM2057
uniprot id: P74879
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family. PduW subfamily.
messages: Cytoplasm
messages: Decreased propionate kinase activity, cells grow to lower density on 1,2-PD and excrete more propionate into the medium. A double pduW-pduX deletion grows as well as wild-type on 1,2-PD.
messages: The BMC operon and BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Was originally (Ref.1) thought to be AckA.
messages: Works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). Ectopic expression partially complements a cobB deletion allowing some growth on propionate (PubMed:12700259). Restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions (PubMed:26448059).

99287:STM2944
gene id: 99287:STM2944
uniprot id: Q8ZME6
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

99287:STM0512
gene id: 99287:STM0512
uniprot id: Q7CR09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

99287:STM0775
gene id: 99287:STM0775
uniprot id: P22714
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit. Zinc binding seems to play a structural role.

99287:STM1463
gene id: 99287:STM1463
uniprot id: Q8ZPL9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.

99287:STM2124
gene id: 99287:STM2124
uniprot id: Q8ZNQ5
names: Similarity
messages: Belongs to the alkylbase DNA glycosidase AlkA family.

99287:STM0383
gene id: 99287:STM0383
uniprot id: Q7CR46
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IraP family.
messages: By phosphate starvation and limiting magnesium, via the transcriptional regulator PhoP and the alarmone ppGpp.
messages: Cytoplasm
messages: Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate and magnesium starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
messages: Interacts with RssB.

99287:STM3345
gene id: 99287:STM3345
uniprot id: P0AA13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

99287:STM0291
gene id: 99287:STM0291
uniprot id: Q8ZRL0
names: Similarity
messages: Belongs to the RHS family.

99287:STM2308
gene id: 99287:STM2308
uniprot id: Q8ZNE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MenH family.
messages: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
messages: Monomer.

99287:STM1129
gene id: 99287:STM1129
uniprot id: P60631
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

99287:STM4160
gene id: 99287:STM4160
uniprot id: Q9L9J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

99287:STM2793
gene id: 99287:STM2793
uniprot id: Q8ZMM0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM4148
gene id: 99287:STM4148
uniprot id: P0AA02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NusG family.
messages: Monomer. Interacts with the transcription termination factor Rho and with RNA polymerase.
messages: Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination.

99287:STM4351
gene id: 99287:STM4351
uniprot id: Q8ZKA9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

99287:STM0632
gene id: 99287:STM0632
uniprot id: P0A2H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TatA/E family. TatE subfamily.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA.

99287:STM0866
gene id: 99287:STM0866
uniprot id: Q8ZQK8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM0575
gene id: 99287:STM0575
uniprot id: Q8ZR47
names: Subcellular Location Annotation
messages: Membrane

99287:STM3872
gene id: 99287:STM3872
uniprot id: Q8ZKW7
names: Subcellular Location Annotation
messages: Membrane

99287:STM1294
gene id: 99287:STM1294
uniprot id: Q8ZPV7
names: Similarity
messages: Belongs to the asparaginase 1 family.

99287:STM4273
gene id: 99287:STM4273
uniprot id: Q8ZKF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell inner membrane
messages: Transports acetate.

99287:STM1107
gene id: 99287:STM1107
uniprot id: Q8ZQ46
names: Subcellular Location Annotation
messages: Membrane

99287:STM2935
gene id: 99287:STM2935
uniprot id: P65672
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

99287:PSLT077
gene id: 99287:PSLT077
uniprot id: H9L4B7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TraA family.
messages: Cell inner membrane
messages: Membrane
messages: Monomer. Interacts with itself to form filaments; also interacts with TraQ.
messages: Secreted

99287:STM3123
gene id: 99287:STM3123
uniprot id: Q8ZM33
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

99287:STM3538
gene id: 99287:STM3538
uniprot id: Q8ZLG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

99287:STM2498
gene id: 99287:STM2498
uniprot id: P0A2M5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

99287:STM1892
gene id: 99287:STM1892
uniprot id: Q8ZNV7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system (Probable). Seems to be important for the virulence.
messages: The complex is composed of two ATP-binding proteins (ZnuC), two transmembrane proteins (ZnuB) and a solute-binding protein (ZnuA).
messages: Transcriptionally repressed by zur (zinc uptake regulator), in response to high extracellular zinc concentrations.

99287:STM3366
gene id: 99287:STM3366
uniprot id: Q7CPM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AaeX family.
messages: Cell membrane

99287:STM2297
gene id: 99287:STM2297
uniprot id: Q8ZNF3
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
messages: Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) (PubMed:12429098, PubMed:24460375). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity).
messages: Homodimer.
messages: Induced by BasR.
messages: Inhibited by L-cycloserine.

99287:STM0071
gene id: 99287:STM0071
uniprot id: Q8ZRX4
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.

99287:STM1718
gene id: 99287:STM1718
uniprot id: P31570
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cob(I)alamin adenosyltransferase family.
messages: Cytoplasm
messages: Homodimer.
messages: Mild growth defect on 1,2-propanediol-cyanocobalamin medium; no growth is seen in a double cobA-pduO deletion.
messages: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.

99287:STM1642
gene id: 99287:STM1642
uniprot id: P63462
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

99287:STM2765
gene id: 99287:STM2765
uniprot id: Q8ZMN9
names: Similarity
messages: Belongs to the transposase 8 family.

99287:STM0231
gene id: 99287:STM0231
uniprot id: P14567
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.
messages: The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore: (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi-beta[4].

99287:STM3711
gene id: 99287:STM3711
uniprot id: P37421
names: Similarity
messages: Belongs to the glycosyltransferase 9 family.

99287:STM1492
gene id: 99287:STM1492
uniprot id: Q8ZPK3
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Deletion of the osmU operon eliminates the residual osmoprotection by glycine betaine in a mutant that is lacking the ProP and the ProU systems. OsmU deletion has no effect on the utilization of glycine betaine as an osmoprotectant when ProP or ProU are functional.
messages: Induced by osmotic stress. Part of the osmU operon, which consists of four genes (osmV, osmW, osmX and osmY).
messages: Part of the OsmU ABC transporter complex, which is involved in the uptake of osmoprotectants such as choline-O-sulfate and glycine betaine. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (OsmV), two transmembrane proteins (OsmW and OsmY) and a solute-binding protein (OsmX).

99287:STM3732
gene id: 99287:STM3732
uniprot id: Q8ZL46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoid occlusion factor SlmA family.
messages: Homodimer. Interacts with FtsZ.
messages: Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
messages: nucleoid

99287:STM0001
gene id: 99287:STM0001
uniprot id: Q7CRA3
names: Function
names: Similarity
messages: Belongs to the thr operon leader peptide family.
messages: This protein is involved in control of the biosynthesis of threonine.

99287:STM2393
gene id: 99287:STM2393
uniprot id: Q8ZNA4
names: Subcellular Location Annotation
messages: Membrane

99287:STM0289
gene id: 99287:STM0289
uniprot id: Q8ZRL1
names: Similarity
messages: Belongs to the VgrG protein family.

99287:STM1351
gene id: 99287:STM1351
uniprot id: Q8ZPS1
names: Function
names: Similarity
messages: Belongs to the bacterial-type ferredoxin family. FixX subfamily.
messages: Could be a 3Fe-4S cluster-containing protein.

99287:STM2452
gene id: 99287:STM2452
uniprot id: Q9ZFU5
names: Subcellular Location Annotation
messages: Cell membrane

99287:STM3987
gene id: 99287:STM3987
uniprot id: Q9L6L1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HemG family.
messages: Binds 1 FMN non-covalently per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic condition uses ubiquinone as an electron acceptor.
messages: Cell inner membrane

99287:STM1695
gene id: 99287:STM1695
uniprot id: P36636
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides.
messages: Loss of resistance to protamine.
messages: Part of the sapA-sapB-sapC-sapD-sapF operon, RNA detected in mid-log phase cells.

99287:STM3622
gene id: 99287:STM3622
uniprot id: Q8ZLB5
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the BcsE family.
messages: Mutants lack the ability to produce a biofilm.
messages: Required for cellulose biosynthesis (PubMed:11929533). May have protease activity (PubMed:11929533), but BcsA is not targeted (PubMed:24942809). Binds bis-(3'-5') cyclic diguanylic acid (c-di-GMP) (PubMed:24942809).

99287:STM2997
gene id: 99287:STM2997
uniprot id: Q8ZMB3
names: Subcellular Location Annotation
messages: Membrane

99287:STM2550
gene id: 99287:STM2550
uniprot id: P0A1Y2
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
messages: Binds 1 siroheme per subunit.
messages: Binds 3 [4Fe-4S] clusters per subunit.
messages: By sulfite.
messages: Cytoplasm
messages: The anaerobic sulfite reductase seems to consist of three subunits.
messages: This enzyme catalyzes the hydrogen sulfide production from sulfite. It is strictly anaerobic. It is regulated by electron acceptors rather than by cysteine.

99287:STM2502
gene id: 99287:STM2502
uniprot id: P0A269
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GppA/Ppx family.
messages: Cell membrane
messages: Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain.
messages: Homodimer.

99287:STM1361
gene id: 99287:STM1361
uniprot id: Q8ZPR2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM2972
gene id: 99287:STM2972
uniprot id: Q8ZMC9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Xni family.
messages: Binds 1 K(+) per subunit. The potassium ion strongly increases the affinity for DNA.
messages: Binds 2 Mg(2+) per subunit. Only one magnesium ion has a direct interaction with the protein, the other interactions are indirect.
messages: Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.

99287:STM1385
gene id: 99287:STM1385
uniprot id: Q7CQM9
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate. TtrB is probably involved in transfer of electrons from TtrC to TtrA. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
messages: Probably composed of three subunits: TtrA, TtrB and TtrC.
messages: Transcriptionally regulated by Fnr and by the TtrR/TtrS two-component regulatory system.

99287:STM3018
gene id: 99287:STM3018
uniprot id: Q8ZM98
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

99287:STM3316
gene id: 99287:STM3316
uniprot id: Q8ZLS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

99287:STM1951
gene id: 99287:STM1951
uniprot id: Q8ZNT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

99287:STM0543
gene id: 99287:STM0543
uniprot id: P37921
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs.
messages: Fimbrium

99287:STM0428
gene id: 99287:STM0428
uniprot id: P96063
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. 2-aminoethylphosphonate importer (TC 3.A.1.11.5) family.
messages: Cell inner membrane
messages: Induced when inorganic phosphate is limiting; this is controlled by PhoB.
messages: Maps to a phosphate-starvation-inducible locus previously known as psiC.
messages: Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import. Probably responsible for energy coupling to the transport system.

99287:STM0965
gene id: 99287:STM0965
uniprot id: Q7CQU3
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

99287:STM2865
gene id: 99287:STM2865
uniprot id: Q8ZMI3
names: Similarity
messages: Belongs to the acetyltransferase YopJ family.

99287:STM3264
gene id: 99287:STM3264
uniprot id: Q8ZLU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LpoA family.
messages: Interacts with PBP1a.
messages: Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).

99287:STM1609
gene id: 99287:STM1609
uniprot id: Q8ZPC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

99287:STM3293
gene id: 99287:STM3293
uniprot id: Q7CPQ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

99287:STM3609
gene id: 99287:STM3609
uniprot id: Q8ZLC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
messages: Cell inner membrane
messages: Membrane

99287:STM2854
gene id: 99287:STM2854
uniprot id: P64419
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

99287:STM3729
gene id: 99287:STM3729
uniprot id: P65960
names: Similarity
messages: Belongs to the UPF0758 family. YicR subfamily.

99287:STM3867
gene id: 99287:STM3867
uniprot id: Q7CPE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

99287:STM3100
gene id: 99287:STM3100
uniprot id: Q8ZM47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Monomer.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

99287:STM0297
gene id: 99287:STM0297
uniprot id: Q8ZRK6
names: Similarity
messages: Belongs to the transposase 8 family.

99287:STM1700
gene id: 99287:STM1700
uniprot id: P16657
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.
messages: Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis (By similarity).
messages: Homotetramer.
messages: The antibiotic diazaborine interferes with the activity by binding to the protein.

99287:STM1076
gene id: 99287:STM1076
uniprot id: P65350
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

99287:STM3177
gene id: 99287:STM3177
uniprot id: P66795
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of flhDC (By similarity).
messages: Phosphorylated by QseC.

99287:STM3317
gene id: 99287:STM3317
uniprot id: Q7CPP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptC family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.
messages: Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

99287:STM1106
gene id: 99287:STM1106
uniprot id: Q8ZQ47
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HpcH/HpaI aldolase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
messages: Homohexamer; trimer of dimers.

99287:STM4168
gene id: 99287:STM4168
uniprot id: P68738
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

99287:STM3367
gene id: 99287:STM3367
uniprot id: Q7CPM6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM1745
gene id: 99287:STM1745
uniprot id: P08005
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
messages: Cell inner membrane
messages: Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.

99287:STM1688
gene id: 99287:STM1688
uniprot id: Q8ZP61
names: Subcellular Location Annotation
messages: Membrane

99287:STM3531
gene id: 99287:STM3531
uniprot id: Q8ZLH0
names: Similarity
messages: Belongs to the IlvD/Edd family.

99287:STM3733
gene id: 99287:STM3733
uniprot id: P08870
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Mg(2+). Mn(2+) can replace Mg(2+) as the divalent metal. The role of the metal is to bind 5-phosphoribose 1-diphosphate and form a Mg-5-phosphoribose 1-diphosphate complex which then serves as substrate for OPRTase.

99287:STM2046
gene id: 99287:STM2046
uniprot id: Q9XDN6
names: Biotechnology
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A minor shell protein of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. The isolated BMC shell component protein ratio for J:A:B':B:K:T:U is approximately 15:10:7:6:1:1:2 (PubMed:12923081). Not required for structural integrity of BMCs nor to mitigate propionaldehyde toxicity, it might be involved in spatial organization of BMCs (PubMed:21239588).
messages: Artificial BMCs can be made in E.coli by expressing pduA-pduB/B'-pduT-pduU-pduN-pduJ-pduK (in this order). Enzymes can be targeted to the BMC, and appear to be encapsulated within it.
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the bacterial microcompartments protein family.
messages: Interacts with shell proteins PduA and PduP and assembly protein PduM.
messages: Releases increased amounts of acetaldehyde when grown on propanediol (PubMed:16585748). Half the cells seem to form BMC aggregates with visible shells, the other half have no BMCs. Grows normally on 1,2-PD and vitamin B12 (PubMed:21239588). A double pduJ-pduK strain grows in an interrupted manner on 1,2-PD and vitamin B12; grows for a while then stops, then restarts as toxic propionaldehyde accumulates and then decreases (PubMed:18296526).
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
messages: The C-terminal 70 residues (positions 90-160) when overexpressed in E.coli bind Fe (PubMed:20870711). Might bind an [Fe-S] cluster in vivo (Probable).

99287:STM2248
gene id: 99287:STM2248
uniprot id: Q8XFK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane
messages: Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity).

99287:STM0831
gene id: 99287:STM0831
uniprot id: Q7CQV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Cytoplasm
messages: During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited.

99287:STM0238
gene id: 99287:STM0238
uniprot id: P67551
names: Similarity
messages: Belongs to the UPF0253 family.

99287:STM3887
gene id: 99287:STM3887
uniprot id: Q8ZKV6
names: Subcellular Location Annotation
messages: Membrane

99287:STM2161
gene id: 99287:STM2161
uniprot id: Q7CQ90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0387 family.
messages: Cell inner membrane

99287:STM4416
gene id: 99287:STM4416
uniprot id: Q8ZK66
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

99287:STM2962
gene id: 99287:STM2962
uniprot id: Q8ZMD7
names: Subcellular Location Annotation
messages: Membrane

99287:STM4367
gene id: 99287:STM4367
uniprot id: Q8ZKA3
names: Cofactor
names: Function
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. Represses hmp expression under conditions of elevated intracellular iron concentrations, in the absence of nitric oxide.

99287:STM0845
gene id: 99287:STM0845
uniprot id: Q56067
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesA/MoeB/ThiF family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD.
messages: Homodimer. Forms a stable heterotetrameric complex of 2 MoeB and 2 MoaD during adenylation of MoaD (By similarity).

99287:STM0136
gene id: 99287:STM0136
uniprot id: Q8ZRT7
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: May bind 1 zinc ion per subunit.
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
messages: Repressed under conditions of excess protein secretion capacity and derepressed when protein secretion becomes limiting. This is regulated by SecM.

99287:STM2302
gene id: 99287:STM2302
uniprot id: O52328
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArnE family.
messages: Cell inner membrane
messages: Heterodimer of ArnE and ArnF.
messages: Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.

99287:STM2510
gene id: 99287:STM2510
uniprot id: Q8ZN60
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

99287:STM2885
gene id: 99287:STM2885
uniprot id: Q56019
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SctE/SipB/YopB family.
messages: Component of the type III secretion system 1 (SPI-1 T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:23544147). SipB/SctE1 and SipC/SctB1 are inserted into the host membrane where they form a pore and allow the translocation of effector proteins into the cytosol of target cells (PubMed:23544147).
messages: Host membrane
messages: Mediates the intimate attachment to target host cells (PubMed:19364837). Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity (PubMed:10051653, PubMed:14662750). Induces membrane fusion in vitro (PubMed:10972796).
messages: Mutant can assemble a fully functional needle complex and can secrete (but cannot translocate) all proteins traveling the SPI-1 T3SS pathway, but the mutant is defective for intimate attachment.
messages: Secreted
messages: Secretion is regulated by the gatekeeper InvE/SctW.
messages: The N-terminal region mediates SPI-1 T3SS-independent secretion (PubMed:17768243). The C-terminal region is necessary for SPI-1 T3SS-mediated secretion (PubMed:17768243). Membrane integration requires both hydrophobic domains and the helical C-terminal region (PubMed:12068811).
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569). This subunit is involved in the formation of a pore, called the translocon, in host membrane (PubMed:23544147). Interacts with SipC/SctB1 (PubMed:23544147). Interacts with the SicA chaperone (PubMed:17768243). Purified SipB/SctE1 assembles into hexamers via an N-terminal protease-resistant domain predicted to form a trimeric coiled coil (PubMed:10972796).

99287:STM1831
gene id: 99287:STM1831
uniprot id: Q7CQD8
names: Subcellular Location Annotation
messages: Membrane

99287:STM3446
gene id: 99287:STM3446
uniprot id: P0A1H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

99287:STM2641
gene id: 99287:STM2641
uniprot id: Q8ZMX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
messages: Cytoplasm

99287:STM0105
gene id: 99287:STM0105
uniprot id: Q8ZRV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell inner membrane
messages: Membrane

99287:STM1179
gene id: 99287:STM1179
uniprot id: P0A1J3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

99287:STM0473
gene id: 99287:STM0473
uniprot id: Q7CR17
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hha/YmoA/Cnu family.
messages: Derepression of genes that are usually coregulated by H-NS and Hha (PubMed:23515315).
messages: Interacts with H-NS and in this complex might contact DNA, which could provide an additional surface for DNA binding to the H-NS-Hha complex; may not bind DNA in the absence of H-NS (PubMed:23515315). In vitro improves the ability of H-NS to bind DNA under a precise set of conditions (PubMed:23515315).
messages: Interacts with H-NS; crystal structures suggest each subunit of an H-NS dimer could bind 1 Hha monomer (PubMed:23515315).

99287:STM0635
gene id: 99287:STM0635
uniprot id: Q8ZR03
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

99287:STM0043
gene id: 99287:STM0043
uniprot id: P0A2B1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

99287:STM2283
gene id: 99287:STM2283
uniprot id: Q8ZNG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

99287:STM1260
gene id: 99287:STM1260
uniprot id: Q7CQQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

99287:STM1651
gene id: 99287:STM1651
uniprot id: Q8ZP89
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.
messages: Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin.

99287:STM0586
gene id: 99287:STM0586
uniprot id: Q8ZR39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Fes family.
messages: Cytoplasm

99287:STM0988
gene id: 99287:STM0988
uniprot id: Q8ZQC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

99287:STM0636
gene id: 99287:STM0636
uniprot id: P67537
names: Similarity
messages: Belongs to the UPF0250 family.

99287:STM1597
gene id: 99287:STM1597
uniprot id: Q8ZPC9
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: 4-aminobutanal can spontaneously cyclize to 1-pyrroline, and 5-aminopentanal to 1-piperideine.
messages: Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
messages: Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
messages: Homotetramer.

99287:STM2958
gene id: 99287:STM2958
uniprot id: H9L438
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM1860
gene id: 99287:STM1860
uniprot id: Q8ZNY3
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

99287:STM1170
gene id: 99287:STM1170
uniprot id: P37169
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Was originally (PubMed:2680969) thought to be involved in mouse virulence. It was later shown that the mutation responsible for the virulence phenotype maps to nearby genes (PubMed:8288531).

99287:STM0820
gene id: 99287:STM0820
uniprot id: Q8ZQN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. RhlE subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

99287:STM0224
gene id: 99287:STM0224
uniprot id: Q8ZRP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.

99287:STM3525
gene id: 99287:STM3525
uniprot id: P64251
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GlpE family.
messages: Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
messages: Cytoplasm

99287:STM4063
gene id: 99287:STM4063
uniprot id: P02906
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm
messages: This protein specifically binds sulfate and is involved in its transmembrane transport.

99287:STM2323
gene id: 99287:STM2323
uniprot id: P0A1Y4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Binds 3 [4Fe-4S] clusters per subunit.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

99287:STM2928
gene id: 99287:STM2928
uniprot id: Q8ZMF8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

99287:STM3097
gene id: 99287:STM3097
uniprot id: Q8ZM50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF nuclease family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

99287:STM2512
gene id: 99287:STM2512
uniprot id: Q8ZN58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

99287:STM2893
gene id: 99287:STM2893
uniprot id: P40612
names: Function
names: Similarity
messages: Belongs to the SpaM family.
messages: Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.

99287:STM3235
gene id: 99287:STM3235
uniprot id: Q8ZLW7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM0353
gene id: 99287:STM0353
uniprot id: Q8ZRG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

99287:STM1226
gene id: 99287:STM1226
uniprot id: P40790
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

99287:STM3211
gene id: 99287:STM3211
uniprot id: P0A2E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

99287:STM1979
gene id: 99287:STM1979
uniprot id: P54700
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell inner membrane
messages: For insertion of FliP into the membrane, cleavage of the signal peptide is important kinetically but not absolutely required.
messages: Plays a role in the flagellum-specific transport system.

99287:STM1963
gene id: 99287:STM1963
uniprot id: P26613
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.

99287:STM3204
gene id: 99287:STM3204
uniprot id: Q8ZLY4
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
messages: Magnesium is required for nucleotidyltransferase activity.
messages: Monomer. Can also form homodimers and oligomers.
messages: Nickel for phosphatase activity.

99287:STM2814
gene id: 99287:STM2814
uniprot id: Q8ZMK9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

99287:STM3360
gene id: 99287:STM3360
uniprot id: P0A1B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Homohexamer.
messages: Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes.

99287:STM2263
gene id: 99287:STM2263
uniprot id: Q8ZNH3
names: Subcellular Location Annotation
messages: Membrane

99287:STM2994
gene id: 99287:STM2994
uniprot id: Q8ZMB6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

99287:STM3263
gene id: 99287:STM3263
uniprot id: Q8ZLU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

99287:STM0129
gene id: 99287:STM0129
uniprot id: Q8ZRU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

99287:STM3173
gene id: 99287:STM3173
uniprot id: P0A257
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Cell inner membrane
messages: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-acyl-carrier-protein as the fatty acyl donor.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

99287:STM4456
gene id: 99287:STM4456
uniprot id: P36640
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Induced by low levels of proline and by osmotic shock. The leader of mgtA mRNA functions as a riboswitch, favoring transcription under low Mg(2+) conditions. Under limiting proline levels the MgtL peptide encoded within the mgtA leader cannot be translated, thereby favoring the transcription of the mgtA ORF. Induction by osmotic shock also depends on translational regulation by MgtL (Probable). Induced by low extracellular levels of Mg(2+).
messages: Mediates magnesium influx to the cytosol.

99287:STM1702
gene id: 99287:STM1702
uniprot id: Q8ZP54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNR ribonuclease family. RNase II subfamily.
messages: Cytoplasm
messages: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.

99287:STM4399
gene id: 99287:STM4399
uniprot id: Q8ZK76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIC family. YtfE subfamily.
messages: Cytoplasm
messages: Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
messages: Homodimer.

99287:STM0097
gene id: 99287:STM0097
uniprot id: Q8ZRV7
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

99287:STM0257
gene id: 99287:STM0257
uniprot id: Q8ZRM5
names: Subcellular Location Annotation
messages: Membrane

99287:STM1339
gene id: 99287:STM1339
uniprot id: P0A1S0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: IHF also plays a crucial role in the lysogenic life cycle of bacteriophage lambda, as it is required not only in the recombination reaction, which inserts lambda DNA into the E.coli chromosome, but also for the synthesis of int and cI repressor, two phage proteins necessary for DNA insertion and repression, respectively. The synthesis of int and cI proteins is regulated indirectly by IHF via translational control of the lambda cII protein.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

99287:STM1524
gene id: 99287:STM1524
uniprot id: Q8ZPI3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

99287:STM2469
gene id: 99287:STM2469
uniprot id: P0A208
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: A putative bidirectional acetate kinase that may drive flux through the ethanolamine (EA) degradation pathway under anoxic conditions found when this bacteria infects host intestine. It may generate ATP that can be used by other enzymes (EutA and EutT) in the eut pathway. Can use GTP instead of ATP with reduced efficiency (PubMed:26448059). Overexpression in E.coli yields elongated protein sheets; prevents artificial BMC formation by eutS alone or by eutK, eutL, eutM, eutN, eutS in E.coli (PubMed:27063436).
messages: Bacterial microcompartment
messages: Belongs to the EutP/PduV family.
messages: Does not need divalent cations.
messages: Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Not required for aerobic growth on ethanolamine (EA) supplemented with cobalamin (vitamin B12). A quadruple eutP-eutQ-eutT-eutD deletion is also not required for growth in the above conditions (PubMed:10464203). A non-polar deletion mutant grows on EA from pH 5.5 to pH 8.0, but does not grow at pH 8.5, releases slightly increased amounts of acetaldehyde on EA plus vitamin B12 (PubMed:16585748). No visible phenotype when grown on EA and tetrathionate under anoxic conditions (PubMed:26448059).
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).

99287:STM3249
gene id: 99287:STM3249
uniprot id: Q7CPQ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
messages: Homohexamer; trimer of dimers.

99287:STM2827
gene id: 99287:STM2827
uniprot id: Q8ZMK6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Homotetramer.

99287:STM1209
gene id: 99287:STM1209
uniprot id: Q8ZQ06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
messages: Cytoplasm
messages: Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Plays a role in beta-lactam antibiotic resistance via its role in generating anhydro-N-acetylmuramic acid-linked peptides; these peptides function as signaling molecules that induce high-level expression of the beta-lactamase AmpC.

99287:STM1567
gene id: 99287:STM1567
uniprot id: Q7CQI9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

99287:STM4467
gene id: 99287:STM4467
uniprot id: Q8ZK33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

99287:STM0618
gene id: 99287:STM0618
uniprot id: Q8ZR15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

99287:STM3637
gene id: 99287:STM3637
uniprot id: P43663
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM3101
gene id: 99287:STM3101
uniprot id: Q7CPT8
names: Similarity
messages: Belongs to the YggT family.

99287:STM2036
gene id: 99287:STM2036
uniprot id: Q05587
names: Disruption Phenotype
names: Function
messages: Increases expression of the entire cob operon about 90-fold irrespective of the growth medium; expression retains its sensitivity to vitamin B12 repression (PubMed:8071226). Cells lacking this gene are defective in aerobic and anaerobic degradation of propanediol (PubMed:9023178, PubMed:7559322).
messages: Positive regulatory protein of pdu and cob operons (PubMed:8071226, PubMed:7559322, PubMed:9023178). Positively autoregulates its own expression (PubMed:7559322).

99287:STM2525
gene id: 99287:STM2525
uniprot id: Q8ZN52
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

99287:STM0213
gene id: 99287:STM0213
uniprot id: Q8ZRP4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

99287:STM4291
gene id: 99287:STM4291
uniprot id: P36557
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Cell inner membrane
messages: Member of the two-component regulatory system BasS/BasR. Autophosphorylates and activates BasR by phosphorylation. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well.
messages: The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions.

99287:STM1234
gene id: 99287:STM1234
uniprot id: Q8ZPZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs.
messages: Cytoplasm
messages: Interacts with TusE.

99287:STM3583
gene id: 99287:STM3583
uniprot id: Q8ZLE2
names: Function
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
messages: May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis. The native apo-protein substrate is unknown.

99287:STM2934
gene id: 99287:STM2934
uniprot id: Q8ZMF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

99287:STM3593
gene id: 99287:STM3593
uniprot id: Q9X6G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmJ family.
messages: Cytoplasm
messages: Specifically methylates the guanosine in position 1516 of 16S rRNA.

99287:STM2352
gene id: 99287:STM2352
uniprot id: P0A2I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter complex HisPMQJ involved in histidine transport (PubMed:7050725, PubMed:9520394). Is also part of the ABC transporter complex HisPMQ-ArgT involved in lysine/arginine/ornithine transport (PubMed:24021237). Probably responsible for the translocation of the substrate across the membrane (Probable). Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (PubMed:9520394).
messages: The HisPMQJ complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ) (PubMed:7050725, PubMed:2033074, PubMed:9520394). The HisPMQ-ArgT complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (ArgT) (PubMed:24021237).

99287:STM0686
gene id: 99287:STM0686
uniprot id: Q8ZQX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

99287:STM3484
gene id: 99287:STM3484
uniprot id: P0DMP3
names: Function
names: Similarity
messages: An alpha subtype methylase, recognizes the double-stranded sequence 5'-GATC-3' and methylates A-2 (PubMed:12654995) (By similarity). May be involved in methyl-directed DNA mismatch repair, initiation of chromosome replication and gene expression (By similarity).
messages: Belongs to the N(4)/N(6)-methyltransferase family.

99287:STM2977
gene id: 99287:STM2977
uniprot id: Q8ZMC5
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of L-fuculose.

99287:STM2529
gene id: 99287:STM2529
uniprot id: Q8ZN49
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

99287:STM0143
gene id: 99287:STM0143
uniprot id: Q8ZRT3
names: Similarity
messages: Belongs to the GSP E family.

99287:STM0511
gene id: 99287:STM0511
uniprot id: Q8ZR89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ).

99287:STM0425
gene id: 99287:STM0425
uniprot id: P55913
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

99287:STM0585
gene id: 99287:STM0585
uniprot id: Q8ZR40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

99287:STM2953
gene id: 99287:STM2953
uniprot id: P65921
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

99287:STM3290
gene id: 99287:STM3290
uniprot id: Q8ZLT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homotetramer.

99287:STM2559
gene id: 99287:STM2559
uniprot id: P0A1Z0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.
messages: Cytoplasm
messages: Homodecamer. Interacts with RavA.

99287:STM2489
gene id: 99287:STM2489
uniprot id: Q8ZN71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

99287:STM3034
gene id: 99287:STM3034
uniprot id: Q7CPV2
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC.
messages: Belongs to the VapB family.
messages: Forms a complex with toxin VapC.
messages: Induced by amino acid starvation and by chloramphenicol treatment.

99287:STM0544
gene id: 99287:STM0544
uniprot id: P37922
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM3330
gene id: 99287:STM3330
uniprot id: Q8ZLR4
names: Similarity
messages: Belongs to the glutamate synthase family.

99287:STM4270
gene id: 99287:STM4270
uniprot id: Q8ZKG0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM4267
gene id: 99287:STM4267
uniprot id: Q8ZKG3
names: Similarity
messages: Belongs to the GST superfamily.

99287:STM1590
gene id: 99287:STM1590
uniprot id: Q8ZPD3
names: Disruption Phenotype
names: Function
names: Subunit
messages: Homodimer.
messages: In minimal medium, cells lacking this gene grow normally with MSO, but growth is inhibited by MSX. In rich medium, growth of cells lacking this gene are partially inhibited by MSX, only when its concentration is at least 50 uM.
messages: Plays a role in the resistance against the toxic effects of L-methionine sulfoximine (MSX), a rare amino acid which inhibits glutamine synthetase (GlnA). Catalyzes the acetylation of MSX. It can also use L-methionine sulfone (MSO) (PubMed:25368301). Also catalyzes the acylation of free L-amino acids using an acyl-CoA as acyl donor (By similarity).

99287:STM3943
gene id: 99287:STM3943
uniprot id: P56978
names: Function
names: Similarity
messages: Belongs to the frataxin family.
messages: Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.

99287:STM3905
gene id: 99287:STM3905
uniprot id: P20506
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
messages: Homotetramer.
messages: Isoleucine allosterically inhibits whereas valine allosterically activates this enzyme.

99287:STM1238
gene id: 99287:STM1238
uniprot id: Q8ZPZ0
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

99287:STM3739
gene id: 99287:STM3739
uniprot id: Q8ZL42
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
messages: Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.

99287:STM1184
gene id: 99287:STM1184
uniprot id: P16326
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

99287:STM3002
gene id: 99287:STM3002
uniprot id: P60959
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane
messages: Mutants accumulate unmodified prolipoprotein due to a defect in the activity of prolipoprotein glyceryl transferase.

99287:STM0106
gene id: 99287:STM0106
uniprot id: Q8ZRV2
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.
messages: Cell inner membrane
messages: Expression is repressed by thiamine.
messages: Insertions in thiBPQ cause a defect in the transport of both thiamine and TPP.
messages: Part of the ABC transporter complex ThiBPQ involved in thiamine import (PubMed:9535878). Responsible for energy coupling to the transport system (Probable). Is also involved in thiamine pyrophosphate (TPP) transport (PubMed:9535878).
messages: The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).

99287:STM4537
gene id: 99287:STM4537
uniprot id: Q8ZJY0
names: Subcellular Location Annotation
messages: Membrane

99287:STM3196
gene id: 99287:STM3196
uniprot id: Q8ZLY9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Homotrimer.
messages: Mutant is growth-deficient under aerobic conditions and is impaired to replicate at physiological and high temperatures (PubMed:21554724, PubMed:28559279). Mutant is defective for proliferation in macrophages and mice infection and has a severe attenuation in virulence in the murine model when inoculated both orally and intraperitoneally (PubMed:21554724, PubMed:28559279). Deletion inhibits colonization and invasion of four human cell lines, impairs flagella formation, activates the expression of type-1 fimbriae-like structures on the cell surface, enhances biofilm formation and reduces bacterial motility. The deletion mutant is menaquinone-deficient (PubMed:27777572).
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis under aerobic conditions. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both. Dispensable for ubiquinone biosynthesis under anaerobiosis (PubMed:28559279). Required for proliferation in macrophages and virulence in mice (PubMed:28559279, PubMed:21554724). Significantly contributes to colonization and invasion as well as host inflammation and innate immunity after infection (PubMed:27777572). In vitro, has membrane fusogenic activity at acidic pH (PubMed:21554724).

99287:STM4190
gene id: 99287:STM4190
uniprot id: P36936
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S51 family.
messages: Cytoplasm
messages: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.

99287:STM2946
gene id: 99287:STM2946
uniprot id: P17853
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
messages: Cytoplasm

99287:STM3883
gene id: 99287:STM3883
uniprot id: Q7CPD9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM3388
gene id: 99287:STM3388
uniprot id: Q8ZLN7
names: Similarity
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.

99287:STM0884
gene id: 99287:STM0884
uniprot id: Q8ZQJ4
names: Subcellular Location Annotation
messages: Membrane

99287:STM2339
gene id: 99287:STM2339
uniprot id: Q7CQ45
names: Subcellular Location Annotation
messages: Membrane

99287:STM4080
gene id: 99287:STM4080
uniprot id: Q8ZKP8
names: Cofactor
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cell membrane
messages: In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor.

99287:STM0230
gene id: 99287:STM0230
uniprot id: P0A2C1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

99287:STM4058
gene id: 99287:STM4058
uniprot id: Q7CPC3
names: Subcellular Location Annotation
messages: Cell inner membrane

99287:STM2378
gene id: 99287:STM2378
uniprot id: Q7CQ36
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

99287:STM3702
gene id: 99287:STM3702
uniprot id: Q7CPH7
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

99287:STM1690
gene id: 99287:STM1690
uniprot id: Q8ZP60
names: Similarity
messages: Belongs to the PspA/IM30 family.

99287:STM4419
gene id: 99287:STM4419
uniprot id: Q8ZK63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell inner membrane
messages: Membrane

99287:STM3245
gene id: 99287:STM3245
uniprot id: Q8ZLW0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM2021
gene id: 99287:STM2021
uniprot id: Q05598
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiQ family.
messages: Cell inner membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry. Expression of just CbiMN in E.coli confers some cobalt uptake.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity.

99287:STM4164
gene id: 99287:STM4164
uniprot id: Q9L9I7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

99287:STM2487
gene id: 99287:STM2487
uniprot id: P65889
names: Similarity
messages: Belongs to the SAICAR synthetase family.

99287:STM1000
gene id: 99287:STM1000
uniprot id: P58696
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

99287:STM0958
gene id: 99287:STM0958
uniprot id: Q7CQU5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

99287:STM0782
gene id: 99287:STM0782
uniprot id: Q7CQW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

99287:STM3054
gene id: 99287:STM3054
uniprot id: Q8ZM75
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

99287:STM4570
gene id: 99287:STM4570
uniprot id: Q8ZJV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:235429). Acts on 6-amino and 6-oxopurines including deoxyinosine, deoxyguanosine, deoxyadenosine, adenosine, guanosine, and inosine (PubMed:235429).
messages: Homohexamer; trimer of homodimers.

99287:STM2786
gene id: 99287:STM2786
uniprot id: Q9FA46
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

99287:STM2580
gene id: 99287:STM2580
uniprot id: Q56057
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

99287:STM0227
gene id: 99287:STM0227
uniprot id: P0A1H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity).

99287:STM3569
gene id: 99287:STM3569
uniprot id: Q8ZLF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

99287:STM0788
gene id: 99287:STM0788
uniprot id: Q8ZQR1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.

99287:STM2540
gene id: 99287:STM2540
uniprot id: Q8ZN41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HscB family.
messages: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.
messages: Interacts with HscA and stimulates its ATPase activity. Interacts with IscU.

99287:STM1320
gene id: 99287:STM1320
uniprot id: Q8ZPT9
names: Subcellular Location Annotation
messages: Membrane

99287:STM1448
gene id: 99287:STM1448
uniprot id: Q8ZPM9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

99287:STM4106
gene id: 99287:STM4106
uniprot id: P17750
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homotetramer.

99287:STM3243
gene id: 99287:STM3243
uniprot id: Q8ZLW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
messages: Cell inner membrane
messages: Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).

99287:STM1450
gene id: 99287:STM1450
uniprot id: Q8ZPM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxine kinase family. PdxY subfamily.
messages: Homodimer.
messages: Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.

99287:STM3015
gene id: 99287:STM3015
uniprot id: Q8ZMA1
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

99287:STM1732
gene id: 99287:STM1732
uniprot id: Q8ZP50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpW/AlkL family.
messages: Cell outer membrane

99287:STM2179
gene id: 99287:STM2179
uniprot id: Q7CQ83
names: Subcellular Location Annotation
messages: Membrane

99287:STM1719
gene id: 99287:STM1719
uniprot id: Q8ZP51
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.
messages: Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA.

99287:STM2017
gene id: 99287:STM2017
uniprot id: Q05602
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

99287:STM1536
gene id: 99287:STM1536
uniprot id: Q8ZPH2
names: Similarity
messages: Belongs to the peptidase A31 family.

99287:STM0665
gene id: 99287:STM0665
uniprot id: Q9ZF60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Binds to both glutamate and aspartate.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (GltL), two transmembrane proteins (GltJ and GltK) and a solute-binding protein (GltI).

99287:STM3592
gene id: 99287:STM3592
uniprot id: Q8ZLD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpB subfamily.
messages: Cell inner membrane
messages: Proton-dependent permease that transports di- and tripeptides.

99287:STM1335
gene id: 99287:STM1335
uniprot id: P0A7Q3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

99287:STM1307
gene id: 99287:STM1307
uniprot id: Q8ZPU8
names: Cofactor
names: Function
names: Induction
names: Similarity
messages: Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: By nitrogen and carbon starvation, and arginine, via the ArgR and Crp transcriptional regulators.
messages: Transforms N(2)-succinylglutamate into succinate and glutamate.

99287:STM3873
gene id: 99287:STM3873
uniprot id: P64237
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: A mutant in which deletion of the last 50 residues in ubiA is combined with the Tyr-56 mutation in rsmG is highly resistant to streptomycin and has a small colony phenotype (which grow slowly and are resistant to aminoglycoside anitbiotics).
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

99287:STM3451
gene id: 99287:STM3451
uniprot id: Q8ZLL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DsrE/TusD family.
messages: Cytoplasm
messages: Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE.

99287:STM3956
gene id: 99287:STM3956
uniprot id: P0A1U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YigI thioesterase family.
messages: Cytoplasm
messages: Displays thioesterase activity against medium- to long-chain acyl-CoA substrates (By similarity). Is involved in the thioesterase-dependent beta-oxidation pathway of (9Z,11E)-octadecadienoate (conjugated linoleic acid or CLA), along with TesB and FadM (By similarity).

99287:STM0307
gene id: 99287:STM0307
uniprot id: Q7CR55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

99287:STM2117
gene id: 99287:STM2117
uniprot id: Q9F7B2
names: Function
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Dephosphorylates Wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium. Involved in protection of cells against contact-dependent growth inhibition (CDI).

99287:STM4034
gene id: 99287:STM4034
uniprot id: Q8ZKT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhE family.
messages: Cytoplasm
messages: Necessary for formate dehydrogenase activity.

99287:STM3152
gene id: 99287:STM3152
uniprot id: Q8ZM14
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

99287:STM1457
gene id: 99287:STM1457
uniprot id: Q8ZPM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.
messages: The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.

99287:STM0493
gene id: 99287:STM0493
uniprot id: Q8ZR98
names: Subcellular Location Annotation
messages: Membrane

99287:STM2191
gene id: 99287:STM2191
uniprot id: P41030
names: Function
names: Subunit
messages: Homodimer.
messages: Repressor of the mgl operon. Binds galactose and D-fucose as inducers. GalS binds to an operator DNA sequence within its own coding sequence (By similarity).

99287:STM1204
gene id: 99287:STM1204
uniprot id: Q8ZQ10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

99287:STM2684
gene id: 99287:STM2684
uniprot id: Q8ZMW1
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

99287:STM1299
gene id: 99287:STM1299
uniprot id: P15111
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.
messages: Homohexamer.

99287:STM2218
gene id: 99287:STM2218
uniprot id: Q8ZNJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

99287:STM3969
gene id: 99287:STM3969
uniprot id: P0A2B7
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

99287:STM3788
gene id: 99287:STM3788
uniprot id: P27669
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Cell inner membrane
messages: Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB.

99287:STM3562
gene id: 99287:STM3562
uniprot id: P30296
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily.
messages: Cell inner membrane
messages: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.

99287:STM0010
gene id: 99287:STM0010
uniprot id: Q7CRA1
names: Similarity
messages: Belongs to the UPF0174 family.

99287:STM1138
gene id: 99287:STM1138
uniprot id: O54290
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: To E.coli YahC.

99287:STM0694
gene id: 99287:STM0694
uniprot id: Q8ZQX1
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase.

99287:STM2290
gene id: 99287:STM2290
uniprot id: Q7CQ58
names: Subcellular Location Annotation
messages: Membrane

99287:STM3207
gene id: 99287:STM3207
uniprot id: P67161
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).
messages: Cell inner membrane
messages: Probably interacts with PlsX.

99287:STM1874
gene id: 99287:STM1874
uniprot id: Q8ZNX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopD family.
messages: Cell inner membrane
messages: Involved in copper resistance.
messages: Membrane

99287:STM1298
gene id: 99287:STM1298
uniprot id: P40687
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

99287:STM0621
gene id: 99287:STM0621
uniprot id: Q8ZR12
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM2087
gene id: 99287:STM2087
uniprot id: P26401
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalyzes the transfer of CDP-abequose on D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid to yield D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid.

99287:STM2307
gene id: 99287:STM2307
uniprot id: Q7CQ56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Homohexamer.

99287:STM2541
gene id: 99287:STM2541
uniprot id: Q7CQ12
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 2 iron ions per dimer. The dimer may bind additional iron ions.
messages: Homodimer; may form tetramers and higher multimers.
messages: Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.

99287:STM2463
gene id: 99287:STM2463
uniprot id: P41793
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as the second step in ethanolamine degradation by converting acetaldehyde into acetyl-CoA (Probable) (PubMed:21803884). Has a very strong preference for NAD(+) over NADP(+) in both catalytic directions (PubMed:21803884). May play a role in bacterial microcompartment (BMC) assembly or maintenance (Probable). Directly targeted to the BMC (PubMed:27450681).
messages: Artificial BMCs can be made in E.coli by expressing eutK, eutL, eutM, eutN, eutS (eutSMNLK) or eutS alone. Cargo proteins can be targeted to them using the first 21 residues of this protein. This can lead to the development of tailored BMCs for specific metabolic reactions.
messages: Bacterial microcompartment
messages: Belongs to the EutE/PduP family.
messages: Can use ethanolamine (EA) as a nitrogen source but not as a carbon source. Slightly attenuated in a mouse model of infection (PubMed:7868611, PubMed:2656649). No aerobic growth on EA supplemented with cobalamin (vitamin B12) (PubMed:10464203, PubMed:16272400). A non-polar deletion mutant does not grow on EA between pH 5.5 and pH 8.5, releases increased amounts of acetaldehyde on EA plus vitamin B12 (PubMed:16585748). A deletion allows growth on acetate, suggesting BMC assembly or maintenance is impaired (PubMed:23585538).
messages: Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Has been used to coproduce acetaldehyde and hydrogen in E.coli.
messages: Interacts with EutS, which targets it to the interior of the BMC.
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).
messages: The first 21 residues target foreign proteins (tested with eGFP) to the BMC in E.coli. The cargo is only detected by Western blot in broken shells, strongly suggesting this protein is normally found inside the BMC and not on its exterior.

99287:STM0491
gene id: 99287:STM0491
uniprot id: Q8ZRA0
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the phosphorylation of guanosine and inosine to GMP and IMP, respectively.

99287:STM4479
gene id: 99287:STM4479
uniprot id: Q8ZK27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

99287:STM0190
gene id: 99287:STM0190
uniprot id: Q8ZRQ3
names: Function
names: Similarity
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

99287:STM0798
gene id: 99287:STM0798
uniprot id: Q8ZQQ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

99287:STM2129
gene id: 99287:STM2129
uniprot id: Q8ZNQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Cell inner membrane

99287:STM0419
gene id: 99287:STM0419
uniprot id: P55881
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: In contrast to other thiamine biosynthetic genes, thiL is not transcriptionally regulated by thiamine-pyrophosphate. Appears to be constitutively expressed.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

99287:STM0216
gene id: 99287:STM0216
uniprot id: P66541
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

99287:STM3383
gene id: 99287:STM3383
uniprot id: P67688
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

99287:STM0732
gene id: 99287:STM0732
uniprot id: P63725
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Cell inner membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers (By similarity).
messages: The heme is bound between the two transmembrane subunits.

99287:STM4330
gene id: 99287:STM4330
uniprot id: P0A1D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

99287:STM0328
gene id: 99287:STM0328
uniprot id: Q8ZRJ1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM1889
gene id: 99287:STM1889
uniprot id: H9L440
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily.
messages: Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to a Kdo(2)-(acyl)-lipid IV(A) to form a Kdo(2)-lipid A.
messages: Cell inner membrane

99287:STM2486
gene id: 99287:STM2486
uniprot id: Q8ZN73
names: Subcellular Location Annotation
messages: Membrane

99287:STM4050
gene id: 99287:STM4050
uniprot id: P27135
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
messages: Cell inner membrane
messages: Uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system).

99287:STM4300
gene id: 99287:STM4300
uniprot id: Q8ZKE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

99287:STM0135
gene id: 99287:STM0135
uniprot id: Q8ZRT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecM family.
messages: Periplasm
messages: Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
messages: cytosol

99287:STM1661
gene id: 99287:STM1661
uniprot id: Q8ZP84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm
messages: Required for resistance to DNA-damaging agents.

99287:STM2016
gene id: 99287:STM2016
uniprot id: Q05603
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB) (PubMed:8206834, PubMed:10587435, PubMed:11441022, Ref.7, PubMed:24121107). Able to use a variety of other nucleotide bases as substrate to create alternative lower ligands for cobamide (PubMed:11441022, Ref.7, PubMed:24121107).
messages: Homodimer.
messages: In vitro assays of this enzyme are performed at pH 10 because at physiological pH (7.0) its activity is undetectable; this makes it difficult to assess the role of mutagenesis of potential proton acceptor active site residues (Glu-174 and Glu-317) (PubMed:24121107).
messages: No growth on cobinamide (CBI); double cobB-cobT deletion mutants do not grow on CBI and DMB (PubMed:8206834).

99287:STM1297
gene id: 99287:STM1297
uniprot id: Q8ZPV5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

99287:STM0139
gene id: 99287:STM0139
uniprot id: P67693
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapD family.
messages: Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
messages: Cytoplasm
messages: Interacts with FtsZ.

99287:STM2639
gene id: 99287:STM2639
uniprot id: Q8ZMY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E.
messages: Belongs to the RseA family.
messages: Cell inner membrane
messages: Interacts 1:1 with ECF RNA polymerase sigma-E (RpoE); this inhibits the interaction of sigma-E with the RNA polymerase catalytic core and leads to a decreased expression of sigma-E-regulated genes. Interacts with RseB.

99287:STM2382
gene id: 99287:STM2382
uniprot id: Q7CQ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell inner membrane
messages: Membrane

99287:STM1144
gene id: 99287:STM1144
uniprot id: P0A1E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgA/CsgB family.
messages: Curlin is the structural subunit of the curli. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin.
messages: Fimbrium

99287:STM0066
gene id: 99287:STM0066
uniprot id: P14845
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

99287:STM0337
gene id: 99287:STM0337
uniprot id: Q8ZRI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM1566
gene id: 99287:STM1566
uniprot id: Q8ZPE8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.
messages: Homotetramer.

99287:STM2390
gene id: 99287:STM2390
uniprot id: Q7CQ33
names: Similarity
messages: Belongs to the UPF0381 family.

99287:STM1516
gene id: 99287:STM1516
uniprot id: Q8ZPI5
names: Subcellular Location Annotation
messages: Membrane

99287:PSLT111
gene id: 99287:PSLT111
uniprot id: Q7DAN4
names: Function
names: Similarity
messages: Belongs to the FinO family.
messages: One of the components on the FinOP fertility inhibition complex, which inhibits the expression of traJ gene, which in turn regulates the expression of some 20 transfer genes. The transfer genes are responsible for the process, called conjugal transfer, in which DNA is transmitted from one bacterial host to another. RNA-binding that interacts with the traJ mRNA and its antisense RNA, finP, stabilizing finP against endonucleolytic degradation and facilitating sense-antisense RNA recognition.

99287:STM2188
gene id: 99287:STM2188
uniprot id: Q56036
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

99287:STM1625
gene id: 99287:STM1625
uniprot id: Q8ZPB0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM3506
gene id: 99287:STM3506
uniprot id: P74884
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Acquisition of Mn(2+) in addition to Fe(2+) is required for intercellular survival, replication in macrophages in vitro and for full virulence in vivo.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Iron uptake is repressed by the global regulator Fur.
messages: Probable transporter for a GTP-driven Fe(2+) uptake system.

99287:STM2842
gene id: 99287:STM2842
uniprot id: Q8ZMJ5
names: Function
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.

99287:STM1875
gene id: 99287:STM1875
uniprot id: Q8ZNX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopC family.
messages: Involved in copper resistance.
messages: Periplasm

99287:STM1535
gene id: 99287:STM1535
uniprot id: Q8ZPH3
names: Similarity
messages: Belongs to the HupF/HypC family.

99287:STM0614
gene id: 99287:STM0614
uniprot id: P67093
names: Similarity
messages: Belongs to the universal stress protein A family.

99287:STM3162
gene id: 99287:STM3162
uniprot id: P0A1F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell inner membrane

99287:STM2354
gene id: 99287:STM2354
uniprot id: P02910
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Has a bi-lobal structure; the two lobes, one bigger than the other, are connected by two short strands and are in contact with each other, enclosing the histidine (PubMed:8307974). Both lobes are involved in stimulating the ATPase activity of HisP (PubMed:9873010).
messages: Part of the ABC transporter complex HisPMQJ involved in histidine transport (PubMed:7050725, PubMed:9520394, PubMed:9873010). Binds histidine (PubMed:9520394, PubMed:9873010). Interacts with HisQMP and stimulates ATPase activity of HisP, which results in histidine translocation (PubMed:9520394, PubMed:9873010). May have some additional function(s) in translocation that is independent of the stimulation of ATP hydrolysis (PubMed:9873010).
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ).

99287:STM1836
gene id: 99287:STM1836
uniprot id: Q7CQD7
names: Function
names: Similarity
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

99287:STM1683
gene id: 99287:STM1683
uniprot id: P0A2D7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Dual transcriptional regulator of the TyrR regulon, which includes a number of genes coding for proteins involved in the biosynthesis or transport of the three aromatic amino acids, phenylalanine, tyrosine and tryptophan. These three aromatic amino acids act as effectors which bind to the TyrR protein to form an active regulatory protein. Acts by binding specifically to TyrR boxes in the promoter region of the target genes.
messages: Homodimer. In presence of tyrosine (or high concentrations of phenylalanine or tryptophan) and ATP, it self-associates to form an hexamer.

99287:STM4382
gene id: 99287:STM4382
uniprot id: Q7CP92
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UlaG family.
messages: Cytoplasm
messages: Induced by L-ascorbate. Repressed by UlaR.
messages: Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions.

99287:STM4153
gene id: 99287:STM4153
uniprot id: P06173
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

99287:STM3695
gene id: 99287:STM3695
uniprot id: Q8ZL60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

99287:STM0682
gene id: 99287:STM0682
uniprot id: Q8ZQX9
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

99287:STM4112
gene id: 99287:STM4112
uniprot id: Q8ZKM6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM4247
gene id: 99287:STM4247
uniprot id: P0A1A3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis.
messages: Monomer.

99287:STM2088
gene id: 99287:STM2088
uniprot id: P26400
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units.

99287:STM3561
gene id: 99287:STM3561
uniprot id: P0A193
names: Caution
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily.
messages: Called LivF in S.typhimurium, but we renamed it to LivG for the sake of consistency with the E.coli protein.
messages: Component of the high-affinity branched-chain amino acid transport system.

99287:STM3832
gene id: 99287:STM3832
uniprot id: Q8ZKY7
names: Subcellular Location Annotation
messages: Membrane

99287:STM1581
gene id: 99287:STM1581
uniprot id: P40788
names: Similarity
names: Subunit
messages: Belongs to the PhzF family.
messages: Homodimer and homotetramer.

99287:STM0959
gene id: 99287:STM0959
uniprot id: P0A2S0
names: Function
names: Subunit
messages: Homodimer.
messages: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes.

99287:STM3918
gene id: 99287:STM3918
uniprot id: Q9L6R7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. WecA subfamily.
messages: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
messages: Cell inner membrane
messages: Inhibited by tunicamycin.

99287:STM2086
gene id: 99287:STM2086
uniprot id: P26402
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

99287:STM2049
gene id: 99287:STM2049
uniprot id: Q9XDN3
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Artificial BMCs can be made in E.coli by expressing pduA-pduB/B'-pduT-pduU-pduN-pduJ-pduK (in this order). Enzymes can be targeted to the BMC, and appear to be encapsulated within it.
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the CcmL/EutN family.
messages: Forms BMCs with a variety of morphologies, including elongated, enlarged, and aggregated MCPs and some with rounded cross-sections. Grows in an interrupted manner on 1,2-PD and vitamin B12; grows for a while then stops, then restarts as if a toxic compound was accumulating and then decreases.
messages: Homopentamer (By similarity). Interacts with shell protein PduA (By similarity).
messages: Probably forms vertices in the shell of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. Required for structural integrity of BMCs and to mitigate propionaldehyde toxicity.
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.

99287:STM1981
gene id: 99287:STM1981
uniprot id: P54702
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell inner membrane
messages: Role in flagellar biosynthesis.

99287:STM2064
gene id: 99287:STM2064
uniprot id: P0A1I1
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 4 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Component of the PhsABC thiosulfate reductase that catalyzes the reduction of thiosulfate to sulfite and hydrogen sulfide, with menaquinol as the sole electron donor. Proton motive force (PMF) is required to drive transmembrane electron transfer within the reductase. The PhsB subunit transfers electrons between PhsC and PhsA.
messages: Composed of three subunits: PhsA, PhsB and PhsC.

99287:STM3580
gene id: 99287:STM3580
uniprot id: Q7CPJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcrB family.
messages: Cell membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis. Essential for lipoprotein maturation under conditions where membrane fluidity may be altered.

99287:STM0811
gene id: 99287:STM0811
uniprot id: Q8ZQP5
names: Subcellular Location Annotation
messages: Membrane

99287:STM1637
gene id: 99287:STM1637
uniprot id: Q8ZP99
names: Subcellular Location Annotation
messages: Membrane

99287:PSLT078
gene id: 99287:PSLT078
uniprot id: H9L485
names: Function
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane protein involved in F pilin formation.

99287:STM2673
gene id: 99287:STM2673
uniprot id: P0A2A1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

99287:STM2496
gene id: 99287:STM2496
uniprot id: Q7CQ21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaA family. HdA subfamily.
messages: Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
messages: The active form seems to be an ADP-bound monomer. Forms the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).

99287:STM3282
gene id: 99287:STM3282
uniprot id: Q8ZLT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Is a global regulator of virulence and persistency.

99287:STM3004
gene id: 99287:STM3004
uniprot id: P65554
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

99287:STM2864
gene id: 99287:STM2864
uniprot id: H9L416
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

99287:STM3449
gene id: 99287:STM3449
uniprot id: Q8ZLL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DsrH/TusB family.
messages: Cytoplasm
messages: Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.

99287:STM0738
gene id: 99287:STM0738
uniprot id: P66869
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

99287:STM2947
gene id: 99287:STM2947
uniprot id: P17845
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 siroheme per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.

99287:STM4455
gene id: 99287:STM4455
uniprot id: P36674
names: Function
names: Induction
names: Subunit
messages: Homodimer.
messages: Probably induced by trehalose-6-phosphate.
messages: Repressor of the treBC operon. It is able to bind trehalose-6-phosphate.

99287:STM3274
gene id: 99287:STM3274
uniprot id: Q7CPQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiU subfamily.
messages: Forms an heterodimer with UbiV.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

99287:STM3921
gene id: 99287:STM3921
uniprot id: Q9L6R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily.
messages: Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
messages: Homodimer.

99287:STM3807
gene id: 99287:STM3807
uniprot id: Q8ZL04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.
messages: Cell membrane

99287:STM0134
gene id: 99287:STM0134
uniprot id: Q8ZRT9
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

99287:STM0333
gene id: 99287:STM0333
uniprot id: Q8ZRI6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM3914
gene id: 99287:STM3914
uniprot id: P0A2P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. RhlB subfamily.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

99287:STM2181
gene id: 99287:STM2181
uniprot id: P60636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0299 family.
messages: Cell inner membrane

99287:STM1622
gene id: 99287:STM1622
uniprot id: Q8ZPB3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OpgD/OpgG family.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
messages: Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).

99287:STM2024
gene id: 99287:STM2024
uniprot id: Q05593
names: Function
names: Similarity
names: Subunit
messages: Belongs to the precorrin methyltransferase family.
messages: Homodimer.
messages: Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway.

99287:STM0364
gene id: 99287:STM0364
uniprot id: P0CL48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Ferrioxamine binding and uptake, in association with the TonB protein.

99287:STM0878
gene id: 99287:STM0878
uniprot id: Q8ZQJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

99287:STM0667
gene id: 99287:STM0667
uniprot id: P0A2L3
names: Function
names: Similarity
messages: Belongs to the UPF0053 family.
messages: Plays a role in the transport of magnesium and cobalt ions.

99287:STM3069
gene id: 99287:STM3069
uniprot id: P65702
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

99287:STM1634
gene id: 99287:STM1634
uniprot id: Q8ZPA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

99287:STM4072
gene id: 99287:STM4072
uniprot id: Q8ZKQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.
messages: Cytoplasm

99287:STM0516
gene id: 99287:STM0516
uniprot id: Q8ZR86
names: Function
messages: Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS-allA intergenic region (By similarity).

99287:STM1004
gene id: 99287:STM1004
uniprot id: P22253
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle (PubMed:9521740). Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release (PubMed:7503993, PubMed:9521740, PubMed:9521741).

99287:STM4006
gene id: 99287:STM4006
uniprot id: P0A2D9
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC.

99287:STM1501
gene id: 99287:STM1501
uniprot id: Q8ZPJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0257 family.
messages: Cell membrane

99287:STM0119
gene id: 99287:STM0119
uniprot id: Q8ZRU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster.
messages: nucleoid

99287:STM3047
gene id: 99287:STM3047
uniprot id: Q7CPV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
messages: Belongs to the SdhE FAD assembly factor family.
messages: Cytoplasm
messages: Monomer.

99287:STM0542
gene id: 99287:STM0542
uniprot id: P58688
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

99287:STM1441
gene id: 99287:STM1441
uniprot id: Q8ZPN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
messages: Cell membrane

99287:STM3765
gene id: 99287:STM3765
uniprot id: O33787
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Cell inner membrane

99287:STM2423
gene id: 99287:STM2423
uniprot id: Q8ZN93
names: Similarity
messages: Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.

99287:STM2679
gene id: 99287:STM2679
uniprot id: Q7CPZ5
names: Subcellular Location Annotation
messages: Membrane

99287:STM4091
gene id: 99287:STM4091
uniprot id: O30911
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: By heat shock.
messages: Cytoplasm

99287:STM2093
gene id: 99287:STM2093
uniprot id: P26395
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster.

99287:STM1357
gene id: 99287:STM1357
uniprot id: Q8ZPR5
names: Function
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons.

99287:STM1796
gene id: 99287:STM1796
uniprot id: Q8ZP20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 37 family.
messages: Monomer.
messages: Periplasm
messages: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.

99287:STM1709
gene id: 99287:STM1709
uniprot id: Q8XFS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapA family.
messages: Cell inner membrane
messages: Involved in the assembly of lipopolysaccharide (LPS).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM0152
gene id: 99287:STM0152
uniprot id: Q8ZRT2
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

99287:STM0374
gene id: 99287:STM0374
uniprot id: Q8ZRF7
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
messages: Belongs to the IprA family.
messages: Deletion mutants display increased resistance to oxidative stress, increased catalase activity and increased survival in macrophage cells. Deletion results in the altered expression of 82 and 56 genes in log and stationary phase, respectively.
messages: Deletion of the N- or the C-terminal 10 amino acids abolishes activity, while a region that includes amino acids 56 to 80 is dispensable for activity. Contains a predicted HTH motif, which may bind DNA.
messages: Involved in oxidative stress resistance.

99287:STM0003
gene id: 99287:STM0003
uniprot id: P65226
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

99287:STM2565
gene id: 99287:STM2565
uniprot id: P74881
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

99287:STM2882
gene id: 99287:STM2882
uniprot id: P0CL52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F-actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization. In vitro, forms a complex with host cell protein T-plastin increasing actin bundling. It inhibits ADF/cofilin-directed depolymerization both by preventing binding of ADF and cofilin and by displacing them from F-actin. Also protects F-actin from gelsolin-directed severing and reanneals gelsolin-severed F-actin fragments.
messages: Belongs to the SipA/IpaA family.
messages: Secreted

99287:STM2856
gene id: 99287:STM2856
uniprot id: Q7CPX9
names: Similarity
messages: Belongs to the HupF/HypC family.

99287:STM0525
gene id: 99287:STM0525
uniprot id: Q8ZR78
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

99287:STM2992
gene id: 99287:STM2992
uniprot id: Q8ZMB8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: Homohexamer.

99287:STM3464
gene id: 99287:STM3464
uniprot id: Q7CPK9
names: Similarity
messages: Belongs to the phosphoribulokinase family.

99287:STM2978
gene id: 99287:STM2978
uniprot id: Q8ZMC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. FucU mutarotase subfamily.
messages: Cytoplasm
messages: Homodecamer.
messages: Involved in the anomeric conversion of L-fucose.

99287:STM2478
gene id: 99287:STM2478
uniprot id: Q8ZN80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S12 family. YfeW subfamily.
messages: Cell inner membrane

99287:STM1631
gene id: 99287:STM1631
uniprot id: Q9FD10
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'GDSL' lipolytic enzyme family.
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and negatively regulates the formation of Salmonella-induced filaments (Sifs) in epithelial cells. Has both deacylase and esterification activities in vitro, but esterification is probably the dominant activity in host cells. Significantly contributes to cholesterol esterification, which reduces cellular cholesterol in cells and abrogates the ability of SifA to associate with cholesterol and LAMP-1 vesicles.
messages: Host cytoplasm
messages: Interacts with RhoA and indirectly with SifA.
messages: Mutants have reduced cholesterol esterification activity as well as reduced lipid droplets.
messages: Secreted

99287:STM3359
gene id: 99287:STM3359
uniprot id: P25077
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.
messages: Homodimer.

99287:STM1411
gene id: 99287:STM1411
uniprot id: P74853
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SctL stator family.
messages: Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:24722491). Acts as a regulator of the SsaN/SctN2 ATPase activity (By similarity).
messages: Cytoplasm
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569). This subunit is part of the cytosolic complex (PubMed:24722491). Interacts directly with SsaN/SctN2 (T3SS-2 ATPase) (PubMed:24722491).

99287:STM3701
gene id: 99287:STM3701
uniprot id: Q7CPH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

99287:STM4457
gene id: 99287:STM4457
uniprot id: Q8ZK39
names: Similarity
messages: Belongs to the transposase 8 family.

99287:STM4451
gene id: 99287:STM4451
uniprot id: Q9L645
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Forms a tetramer composed of two NrdD and two NrdG subunits.

99287:STM0042
gene id: 99287:STM0042
uniprot id: Q8ZRZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

99287:PSLT066
gene id: 99287:PSLT066
uniprot id: Q93GP7
names: Function
names: Subunit
messages: Homotetramer.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

99287:STM3347
gene id: 99287:STM3347
uniprot id: Q8ZLQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZapG family.
messages: Cell inner membrane
messages: Membrane

99287:STM3350
gene id: 99287:STM3350
uniprot id: Q8ZLQ0
names: Similarity
messages: Belongs to the CitG/MdcB family.

99287:PSLT041
gene id: 99287:PSLT041
uniprot id: P13041
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm
messages: Positive regulator for the plasmid-encoded virulence factors SpvA, SpvB, and SpvC.

99287:STM0255
gene id: 99287:STM0255
uniprot id: Q8ZRM7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2-keto-L-gulonic acid is a key intermediate in the production of L-ascorbic acid (vitamin C).
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
messages: Cytoplasm
messages: Monomer.

99287:STM1803
gene id: 99287:STM1803
uniprot id: Q8ZP17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DadA oxidoreductase family.
messages: Cell inner membrane
messages: Oxidative deamination of D-amino acids.

99287:STM1676
gene id: 99287:STM1676
uniprot id: Q8ZP71
names: Subunit
messages: Monomer.

99287:STM3241
gene id: 99287:STM3241
uniprot id: Q8ZLW2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

99287:STM0766
gene id: 99287:STM0766
uniprot id: P58650
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.

99287:STM0548
gene id: 99287:STM0548
uniprot id: P37926
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM0592
gene id: 99287:STM0592
uniprot id: Q7CQZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

99287:STM4593
gene id: 99287:STM4593
uniprot id: Q8ZJU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

99287:STM3137
gene id: 99287:STM3137
uniprot id: Q8ZM23
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

99287:STM3597
gene id: 99287:STM3597
uniprot id: Q8ZLD4
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

99287:STM2749
gene id: 99287:STM2749
uniprot id: Q8ZMQ5
names: Similarity
messages: Belongs to the ner transcriptional regulatory family.

99287:STM2089
gene id: 99287:STM2089
uniprot id: P0A1P4
names: Miscellaneous
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: The functional difference between abequose synthase and paratose synthase lies in the side of the pyranose ring from which the keto group on carbon 4 is attacked in the reduction of CDP-4-keto-3,6-dideoxy-D-glucose.

99287:STM2454
gene id: 99287:STM2454
uniprot id: Q9ZFU7
names: Disruption Phenotype
names: Function
names: Induction
messages: Activates the transcription of the eut operon, allowing utilization of ethanolamine (EA). Positively regulates its own transcription (Probable) (PubMed:1328159, PubMed:8113167). Probably binds EA and vitamin B12 as effectors (Probable). Competes with ethanolamine ammonia-lysase (EAL, the first enzyme in the EA degradation pathway) for adenosylcobalamin (PubMed:8113167). Ethanolamine-associated signaling mediated via this protein, but not EA degradation, impacts S.typhimurium survival within macrophages. Binds the promoter of ssrB and eutS in vitro; in mouse infection models binding to ssrB probably induces all 4 operons of pathogenicity island SPI-2 (PubMed:26565973).
messages: Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient in infection (PubMed:29531136).
messages: Mutations prevent expression of the entire eut operon (PubMed:2656649). No phenotype during bacterial growth in vitro. About 10-fold outcompeted by wild-type in mouse intestines at 2 and 4 days following oral infection. Loss of induction of pathogenicity island SPI-2 in mouse macrophages (PubMed:26684793). About 25% reduction in survival in mouse macrophage assays. Bacteria growth is not enhanced by exogenous EA in macrophage survival assays (PubMed:29531136).
messages: Part of the 17-gene eut operon transcribed from a single promoter, positively regulates its own expression, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12). This is the last gene in the operon and has a second weaker promoter that is constitutively transcribed at a low level (PubMed:10464203, PubMed:3045078, PubMed:1328159, PubMed:26565973) (Probable). Subject to catabolite repression; expression is substantially lower during growth on glucose than during growth versus succinate. Catabolite repression is overcome by adding exogenous cAMP to the glucose growth media (PubMed:1328159). Induced after phagocytosis by mouse RAW macrophages and in spleen in mouse infection; the whole eut operon is not induced (PubMed:26565973).

99287:STM0304
gene id: 99287:STM0304
uniprot id: P37459
names: Function
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.
messages: Probable regulatory protein. Its target is not known.

99287:STM3472
gene id: 99287:STM3472
uniprot id: P20753
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
messages: Periplasm

99287:STM2964
gene id: 99287:STM2964
uniprot id: Q8ZMD5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil-65 in transfer RNAs.

99287:STM3378
gene id: 99287:STM3378
uniprot id: Q8ZLP1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell inner membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

99287:STM2876
gene id: 99287:STM2876
uniprot id: P43015
names: Function
names: Induction
messages: Expressed in response to both environmental conditions and genetic regulatory factors. Transcription is subject to complex control and is stimulated by the SPI1-encoded HilC and HilD.
messages: The main transcriptional regulator of the Salmonella pathogenicity island 1 (SPI1) gene expression. Activates the expression of invasion genes by a direct action at their promoters and also indirectly by increasing the level of InvF. Also binds upstream of prgH and directly activates the expression of prgHIJK operon.

99287:STM0223
gene id: 99287:STM0223
uniprot id: Q8ZRP1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA (By similarity).
messages: Belongs to the peptidase M50B family.
messages: Cell inner membrane
messages: Interacts with RseA.
messages: Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this enzyme), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein (By similarity).
messages: The 2 circularly premutated PDZ domains act to negatively regulate protease action on intact RseA.

99287:STM2128
gene id: 99287:STM2128
uniprot id: Q8ZNQ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
messages: Cell inner membrane
messages: Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtC forms a heteromultimer with MdtB.

99287:STM1765
gene id: 99287:STM1765
uniprot id: Q8ZP36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Cell membrane
messages: Membrane

99287:STM0749
gene id: 99287:STM0749
uniprot id: Q7CQW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

99287:STM0369
gene id: 99287:STM0369
uniprot id: Q56063
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Cells lacking this gene are unable to accumulate propionyl-CoA.
messages: Homodimer at low concentrations and converted to a larger oligomers at higher concentrations.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA or butyryl-CoA but with a lower specificity.

99287:STM0982
gene id: 99287:STM0982
uniprot id: P64394
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

99287:STM2555
gene id: 99287:STM2555
uniprot id: P0A2E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

99287:STM3535
gene id: 99287:STM3535
uniprot id: P05416
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

99287:STM1624
gene id: 99287:STM1624
uniprot id: Q8ZPB1
names: Similarity
messages: Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.

99287:STM3694
gene id: 99287:STM3694
uniprot id: Q8ZL61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
messages: Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.
messages: Cell inner membrane

99287:STM4221
gene id: 99287:STM4221
uniprot id: Q8ZKI4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Increases acid tolerance in rpoS mutants, defective in glucose metabolism.

99287:STM0318
gene id: 99287:STM0318
uniprot id: P37722
names: Function
names: Similarity
messages: Belongs to the FrsA family.
messages: Catalyzes the hydrolysis of esters.

99287:STM0064
gene id: 99287:STM0064
uniprot id: Q8ZRX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

99287:STM3218
gene id: 99287:STM3218
uniprot id: Q8ZLX7
names: Function
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.
messages: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-aminobutanal. Also functions as a cadaverine transaminase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.

99287:STM1894
gene id: 99287:STM1894
uniprot id: P66755
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA (By similarity). In complex with Holliday junction (HJ) DNA, endogenous RuvA and ATP, catalyzes branch migration (PubMed:36002576).

99287:STM0688
gene id: 99287:STM0688
uniprot id: Q8ZQX4
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cell membrane
messages: ChiQ appears dispensable for growth on either chitobiose or chitotriose.
messages: In the absence of chitobiose, expression of chiPQ is silenced by the ChiX small regulatory RNA (sRNA), which sequesters the ribosome binding site of the chiPQ mRNA by an antisense mechanism. In the presence of chitosugars, the chbBCARFG chitobiose operon is induced and acts as an RNA trap to degrade the constitutively expressed ChiX, leading to the translation of chiPQ. Chitobiose and chitotriose also induce chiP mRNA synthesis.

99287:STM2337
gene id: 99287:STM2337
uniprot id: P63411
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Has broad substrate specificity and can also utilize GTP, UTP and CTP. Can also phosphorylate propionate, but has very low activity with formate and is inactive with butyrate.
messages: Cytoplasm
messages: Does not grow on ethanolamine and tetrathionate under anoxic conditions; complemented by acetate kinases EutQ.
messages: Homodimer.
messages: Inhibited by EDTA, butyrate and citrate.
messages: Mg(2+). Can also accept Mn(2+).

99287:STM3364
gene id: 99287:STM3364
uniprot id: Q8ZLP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
messages: Cell inner membrane
messages: Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.

99287:STM4096
gene id: 99287:STM4096
uniprot id: P66191
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

99287:STM3355
gene id: 99287:STM3355
uniprot id: Q7CPN1
names: Similarity
messages: Belongs to the class-I fumarase family.

99287:STM2287
gene id: 99287:STM2287
uniprot id: Q8ZNG2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C79 family.
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells. Specifically hydrolyzes mono- and polyubiquitin substrates in vitro with a preference for 'Lys-63'-linked ubiquitin chains, suggesting that it interferes with a signaling pathway rather than inhibiting proteasomal-dependent degradation of its targets. Does not possess desumoylating activity. Is required for the Salmonella-induced delayed cytotoxicity in macrophages and full virulence. Is not required for intracellular bacterial replication.
messages: Expression of the gene is induced inside phagocytic cells and is dependent on the SsrA/SsrB system.
messages: Host cytoplasm
messages: Secreted

99287:STM0439
gene id: 99287:STM0439
uniprot id: Q8ZRC4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell inner membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.

99287:STM3009
gene id: 99287:STM3009
uniprot id: Q8ZMA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
messages: Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
messages: Cell inner membrane

99287:STM0004
gene id: 99287:STM0004
uniprot id: Q8ZS18
names: Similarity
messages: Belongs to the threonine synthase family.

99287:STM3572
gene id: 99287:STM3572
uniprot id: Q8ZLE8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmD family.
messages: Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.

99287:STM0837
gene id: 99287:STM0837
uniprot id: Q7CQV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YkuD family.
messages: Periplasm

99287:STM2551
gene id: 99287:STM2551
uniprot id: Q8ZN38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA subfamily.
messages: Cell membrane
messages: Efflux system for nickel and cobalt.
messages: Membrane

99287:STM4386
gene id: 99287:STM4386
uniprot id: Q8ZK87
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the HPS/KGPDC family. KGPDC subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization.
messages: Homodimer.
messages: Induced by L-ascorbate. Repressed by UlaR.

99287:STM3513
gene id: 99287:STM3513
uniprot id: Q8ZLI5
names: Similarity
messages: Belongs to the disproportionating enzyme family.

99287:STM2058
gene id: 99287:STM2058
uniprot id: Q9XDM4
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. PduX subfamily.
messages: Catalysis proceeds by a steady-state ordered bi-bi complex mechanism in which ATP is the first substrate to bind.
messages: Cytoplasm
messages: Growth is impaired on 1,2-PD minimal medium supplemented with cobyric acid, but is restored on similar medium supplemented with vitamin B12, cobinamide (PubMed:18308727). A double pduW-pduX deletion grows as well as wild-type on 1,2-PD (PubMed:12700259).
messages: L-threonine kinase that catalyzes the conversion of L-threonine to L-threonine-O-3-phosphate. Involved in the de novo synthesis of adenosylcobalamin (coenzyme B12) and the assimilation of cobyric acid. Uses ATP; the activity with CTP, GTP or UTP is 6, 11, and 3% of the activity with ATP, respectively.
messages: The 1,2-propanediol (1,2-PD)-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low. This gene probably benefits from its induction via the Pdu promoter, rather than a physical interaction with the BMC.
messages: The BMC operon and BMC production is induced by growth on 1,2-PD vitamin B12 medium.

99287:STM1913
gene id: 99287:STM1913
uniprot id: P40729
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell inner membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

99287:STM4287
gene id: 99287:STM4287
uniprot id: Q8ZKE6
names: Cofactor
names: Function
names: Miscellaneous
names: Subunit
messages: Aminoalkylphosphonate N-acetyltransferase which is able to acetylate a range of aminoalkylphosphonic acids, including (S)-1-aminoethylphosphonate ((S)-1AEP) and 2-aminoethylphosphonate, using acetyl-CoA as acetyl donor. Its physiological role in S.typhimurium is unclear. However, by acetylating (S)-1AEP, PhnO would protect against the deleterious effects of (S)-1AEP, a structural analog of D-alanine that has antibacterial properties.
messages: Homodimer.
messages: Reaction proceeds via an ordered, sequential kinetic mechanism with AcCoA binding first followed by aminoalkylphosphonate.
messages: Requires a divalent metal ion for activity. In vitro, exhibits a preference for Ni(2+) followed by Mn(2+) and very poor activity with Mg(2+). However, it is unclear what the physiologically relevant metal ion is.

99287:STM0485
gene id: 99287:STM0485
uniprot id: P0A8B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

99287:STM0556
gene id: 99287:STM0556
uniprot id: Q8ZR62
names: Similarity
messages: Belongs to the transposase 8 family.

99287:STM1130
gene id: 99287:STM1130
uniprot id: Q8ZQ34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NanM family.
messages: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.
messages: Homodimer.
messages: Periplasm

99287:STM3060
gene id: 99287:STM3060
uniprot id: Q7CPU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

99287:STM0140
gene id: 99287:STM0140
uniprot id: P63828
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

99287:STM3736
gene id: 99287:STM3736
uniprot id: Q8ZL45
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM3283
gene id: 99287:STM3283
uniprot id: P66431
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

99287:STM0339
gene id: 99287:STM0339
uniprot id: Q8ZRI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

99287:STM1912
gene id: 99287:STM1912
uniprot id: P0A1N4
names: Function
messages: Not essential for flagellar formation and function.

99287:STM3503
gene id: 99287:STM3503
uniprot id: Q8ZLJ2
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

99287:STM2459
gene id: 99287:STM2459
uniprot id: Q9ZFV2
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the EutA family.
messages: Can use ethanolamine (EA) as a nitrogen source when AdoCbl but not cyano-B12 or hydroxy-B12 is provided; cannot use EA as a carbon source (PubMed:2656649, PubMed:15516577). Required for aerobic growth on ethanolamine supplemented with cobalamin (vitamin B12) (PubMed:10464203). A non-polar deletion mutant does not grow on EA between pH 5.5 and pH 8.5 (PubMed:16585748).
messages: Expression of the eut operon allows this bacteria to use ethanolamine as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).
messages: Reactivates suicidally inhibited ethanolamine ammonia-lyase (EAL), cyanocobalamin-inactivated EAL and O(2)-inactivated EAL; requires Mg(2+), ATP and adenosylcobalamin. Reactivation probably occurs by the ATP-dependent exchange of cobalamin (By similarity). Protects EAL from inhibition by CN-B12, does not have adenosylation activity (PubMed:15516577) (Probable).

99287:STM1966
gene id: 99287:STM1966
uniprot id: P0AA34
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

99287:STM3901
gene id: 99287:STM3901
uniprot id: Q9L6T2
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

99287:STM4475
gene id: 99287:STM4475
uniprot id: Q8ZK31
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

99287:STM3307
gene id: 99287:STM3307
uniprot id: P65454
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

99287:STM3589
gene id: 99287:STM3589
uniprot id: Q7CPJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily.
messages: Membrane

99287:STM1318
gene id: 99287:STM1318
uniprot id: H9L460
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

99287:STM2325
gene id: 99287:STM2325
uniprot id: P0A1Y8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

99287:STM4037
gene id: 99287:STM4037
uniprot id: Q8ZKS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Periplasm

99287:STM0706
gene id: 99287:STM0706
uniprot id: Q8ZQW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

99287:STM4582
gene id: 99287:STM4582
uniprot id: P39434
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase Slt family.
messages: Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity).
messages: Periplasm

99287:STM1401
gene id: 99287:STM1401
uniprot id: Q9R803
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SctB/EspB family.
messages: Cell surface
messages: Component of the type III secretion system 2 (SPI-2 T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (Probable). SseC/SctE2 and SseD/SctB2 are inserted into the host membrane where they form a pore and allow the translocation of effector proteins into the cytosol of target cells (Probable).
messages: Disruption prevents SpvB-induced F-actin depolymerization in human macrophages without affecting intra-bacterial SpvB protein levels.
messages: Host membrane
messages: Required for the translocation of SPI-2 effector proteins (PubMed:11567004). Required for systemic Salmonella infection of the mouse (PubMed:11159962). Essential for SpvB-induced actin depolymerization in the host cell cytoplasm (PubMed:18248436).
messages: Secreted
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569). This subunit is involved in the formation of a pore, called the translocon, in host membrane (Probable). May form a complex with SseB and SseC/SctE2 (PubMed:11567004). SseB is required for correct localization of SseD/SctB2 on the bacterial cell surface (PubMed:11567004). Binds to the chaperone SseA (PubMed:12724372, PubMed:15256549).

99287:STM1888
gene id: 99287:STM1888
uniprot id: Q8ZNW0
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by AMP and by several sugar phosphates. Belongs to type II PK.
messages: Belongs to the pyruvate kinase family.
messages: Catalyzes the formation of pyruvate in the last step of glycolysis, it is irreversible under physiological conditions. The reaction is critical for the control of metabolic flux in the second part of glycolysis.
messages: Homotetramer.

99287:STM4594
gene id: 99287:STM4594
uniprot id: Q8ZJU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

99287:STM3201
gene id: 99287:STM3201
uniprot id: Q8ZLY6
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

99287:STM3170
gene id: 99287:STM3170
uniprot id: Q8ZM01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

99287:STM4068
gene id: 99287:STM4068
uniprot id: Q8ZKR0
names: Disruption Phenotype
names: Function
messages: Null mutant gains the ability to efficiently use exogenous aminoimidazole riboside (AIRs) as a source of thiamine.
messages: Represses the expression of the STM4065-STM4067 operon.

99287:STM0133
gene id: 99287:STM0133
uniprot id: Q8ZRU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

99287:STM2571
gene id: 99287:STM2571
uniprot id: Q8ZN25
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Induced by MurNAc 6-phosphate that releases the repressor MurR from the DNA. Repressed by MurR in the absence of MurNAc 6-phosphate.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

99287:STM1494
gene id: 99287:STM1494
uniprot id: Q8ZPK1
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Deletion of the osmU operon eliminates the residual osmoprotection by glycine betaine in a mutant that is lacking the ProP and the ProU systems. OsmU deletion has no effect on the utilization of glycine betaine as an osmoprotectant when ProP or ProU are functional.
messages: Induced by osmotic stress. Part of the osmU operon, which consists of four genes (osmV, osmW, osmX and osmY).
messages: Part of the OsmU ABC transporter complex, which is involved in the uptake of osmoprotectants such as choline-O-sulfate and glycine betaine. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (OsmV), two transmembrane proteins (OsmW and OsmY) and a solute-binding protein (OsmX).

99287:STM3607
gene id: 99287:STM3607
uniprot id: Q8ZLC4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM0436
gene id: 99287:STM0436
uniprot id: Q8ZRC8
names: Subcellular Location Annotation
messages: Membrane

99287:STM0671
gene id: 99287:STM0671
uniprot id: Q8ZQY2
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

99287:STM4304
gene id: 99287:STM4304
uniprot id: Q8ZKD8
names: Subcellular Location Annotation
messages: Membrane

99287:STM4453
gene id: 99287:STM4453
uniprot id: Q8ZK40
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

99287:STM2166
gene id: 99287:STM2166
uniprot id: Q56078
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 3 family.
messages: Periplasm

99287:STM2071
gene id: 99287:STM2071
uniprot id: P00499
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
messages: Cytoplasm
messages: Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme (Probable).
messages: Feedback inhibited by histidine. Also inhibited by AMP and ADP.
messages: Repressed by ppGpp in the presence of histidine.

99287:STM3898
gene id: 99287:STM3898
uniprot id: Q7CPD8
names: Similarity
messages: Belongs to the UPF0438 family.

99287:STM1558
gene id: 99287:STM1558
uniprot id: Q8ZPF2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

99287:STM2773
gene id: 99287:STM2773
uniprot id: Q8ZMN4
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

99287:STM3970
gene id: 99287:STM3970
uniprot id: P0A2K5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

99287:STM1802
gene id: 99287:STM1802
uniprot id: P06191
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alanine racemase family.
messages: Inactivated by D- and L-beta-fluoroalanine, D- and L-beta-chloroalanine, and O-acetyl-D-serine.
messages: Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA.
messages: Monomer.

99287:STM2441
gene id: 99287:STM2441
uniprot id: P40860
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

99287:STM0859
gene id: 99287:STM0859
uniprot id: Q8ZQL5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM4391
gene id: 99287:STM4391
uniprot id: P66593
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

99287:STM3016
gene id: 99287:STM3016
uniprot id: Q8ZMA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell inner membrane
messages: Membrane

99287:STM2155
gene id: 99287:STM2155
uniprot id: Q8ZNN4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

99287:STM3793
gene id: 99287:STM3793
uniprot id: Q7CPF5
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

99287:STM4326
gene id: 99287:STM4326
uniprot id: Q7CPA1
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

99287:STM3064
gene id: 99287:STM3064
uniprot id: P58509
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LysR transcriptional regulatory family.
messages: Controls the transcription of genes involved in arginine and lysine metabolism.
messages: Homodimer.

99287:STM0074
gene id: 99287:STM0074
uniprot id: Q8ZRX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.
messages: Catalyzes the exchange of L-carnitine for gamma-butyrobetaine.
messages: Cell inner membrane
messages: Homotrimer.

99287:STM0499
gene id: 99287:STM0499
uniprot id: Q93CH6
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: It contains a N-terminal DNA binding region and a C-terminal metal binding region.
messages: Loss of copper-based induction of copA. Causes a mild defect in aerobic growth on CuSO(4), strongly impairs survival during anaerobic growth on CuSO(4).
messages: Regulates the transcription of the copA and cuiD (cueO) genes. Detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (PubMed:17768242).

99287:STM2895
gene id: 99287:STM2895
uniprot id: P0A1N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SpaK family.
messages: Homodimer.
messages: Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA.

99287:STM1901
gene id: 99287:STM1901
uniprot id: Q8ZNV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.

99287:STM0472
gene id: 99287:STM0472
uniprot id: Q8ZRA8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

99287:STM0769
gene id: 99287:STM0769
uniprot id: Q8ZQS5
names: Similarity
messages: Belongs to the CitG/MdcB family.

99287:STM0762
gene id: 99287:STM0762
uniprot id: Q8ZQT0
names: Similarity
messages: Belongs to the class-I fumarase family.

99287:STM0930
gene id: 99287:STM0930
uniprot id: P67286
names: Similarity
messages: Belongs to the UPF0145 family.

99287:STM1738
gene id: 99287:STM1738
uniprot id: Q7CQF5
names: Similarity
messages: Belongs to the YciI family.

99287:STM1172
gene id: 99287:STM1172
uniprot id: P26477
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgM family.
messages: Cytoplasm
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.
messages: The N-terminal domain is essential for export and the C-terminal domain possess the FliA binding site.

99287:STM1647
gene id: 99287:STM1647
uniprot id: Q8ZP91
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

99287:STM2247
gene id: 99287:STM2247
uniprot id: Q8ZNI0
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

99287:STM1191
gene id: 99287:STM1191
uniprot id: P0A7N6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

99287:STM0983
gene id: 99287:STM0983
uniprot id: Q8ZQC3
names: Subcellular Location Annotation
messages: Membrane

99287:STM4410
gene id: 99287:STM4410
uniprot id: Q8ZK70
names: Subcellular Location Annotation
messages: Membrane

99287:STM1146
gene id: 99287:STM1146
uniprot id: P0A1T0
names: Similarity
messages: To the N-terminal of the FimA/PapA family of fimbria proteins.

99287:STM2073
gene id: 99287:STM2073
uniprot id: P10369
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

99287:STM3581
gene id: 99287:STM3581
uniprot id: Q8ZLE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. YhhS family.
messages: Cell inner membrane

99287:STM2055
gene id: 99287:STM2055
uniprot id: P0A1D1
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A minor shell protein of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. The isolated BMC shell component protein ratio for J:A:B':B:K:T:U is approximately 15:10:7:6:1:1:2 (PubMed:12923081). Not required for structural integrity of BMCs nor to mitigate propionaldehyde toxicity, may selectively transport specific metabolites (PubMed:21239588). Proteins such as this one with circularly permuted BMC domains may play a key role in conferring heterogeneity and flexibility in this BMC (Probable).
messages: Artificial BMCs can be made in E.coli by expressing pduA-pduB/B'-pduT-pduU-pduN-pduJ-pduK (in this order). Enzymes can be targeted to the BMC, and appear to be encapsulated within it.
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the EutS/PduU family.
messages: Homohexamer with a central pore lined by a beta-barrel. Hexamers pack into a loose array (PubMed:18786396). Interacts with PduV, probably via the beta-barrel which is predicted by modeling to be on the exterior of the BMC (PubMed:25646976).
messages: No visible effect on BMC morphology. Slight growth impairment on 1,2-propanediol and vitamin B12.
messages: One side of the hexamer is concave which is lined by hydrophobic residues, the other side has a slightly protruding, 6-stranded beta-barrel which is occluded in PDB:3CGI by side chains.
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.

99287:STM4426
gene id: 99287:STM4426
uniprot id: H9L4C2
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

99287:STM0462
gene id: 99287:STM0462
uniprot id: Q7CR20
names: Similarity
messages: Belongs to the P(II) protein family.

99287:STM0446
gene id: 99287:STM0446
uniprot id: Q7CR25
names: Similarity
messages: Belongs to the BolA/IbaG family.

99287:STM0184
gene id: 99287:STM0184
uniprot id: Q8ZRQ8
names: Function
names: Similarity
messages: Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

99287:STM3555
gene id: 99287:STM3555
uniprot id: Q8ZLF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.
messages: Cell inner membrane
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

99287:STM1660
gene id: 99287:STM1660
uniprot id: P0A2T8
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Cytoplasm
messages: Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration (By similarity).
messages: Homodimer.

99287:STM1752
gene id: 99287:STM1752
uniprot id: Q7CQF2
names: Similarity
messages: Belongs to the UDPGP type 2 family.

99287:STM2477
gene id: 99287:STM2477
uniprot id: Q7CQ25
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudK subfamily.
messages: Homodimer.
messages: In the dimer, the N-terminal domains are swapped between the two monomers, such that residues of both chains contribute to the active site.
messages: Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.

99287:STM3623
gene id: 99287:STM3623
uniprot id: Q7CPI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BcsF family.
messages: Cell inner membrane
messages: Required for cellulose biosynthesis.

99287:STM0629
gene id: 99287:STM0629
uniprot id: Q7CQZ5
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM1169
gene id: 99287:STM1169
uniprot id: P37168
names: Caution
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.
messages: Was originally (PubMed:2680969) thought to be involved in mouse virulence. It was later shown that the mutation responsible for the virulence phenotype maps to nearby genes (PubMed:8288531).

99287:STM1313
gene id: 99287:STM1313
uniprot id: Q8ZPU4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

99287:STM2431
gene id: 99287:STM2431
uniprot id: P0AA07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HPr family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

99287:STM3917
gene id: 99287:STM3917
uniprot id: P0A295
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

99287:STM1432
gene id: 99287:STM1432
uniprot id: Q8ZPN8
names: Similarity
messages: Belongs to the peptidase C40 family.

99287:STM0263
gene id: 99287:STM0263
uniprot id: P0A2B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

99287:STM3828
gene id: 99287:STM3828
uniprot id: Q8ZKZ1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.
messages: Reaction proceeds via an anti dehydration.

99287:STM4517
gene id: 99287:STM4517
uniprot id: Q7CP73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell inner membrane
messages: Proton-dependent efflux pump (By similarity). Confers resistance to a broad spectrum of chemically unrelated substrates (By similarity).

99287:STM3122
gene id: 99287:STM3122
uniprot id: Q8ZM34
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

99287:STM0875
gene id: 99287:STM0875
uniprot id: P0A2U2
names: Cofactor
names: Function
names: Similarity
messages: An L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein bS6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH.
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

99287:STM0513
gene id: 99287:STM0513
uniprot id: Q8ZR88
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the SelU family.
messages: Composed of a rhodanese domain and a P-loop domain, which probably binds geranyl diphosphate. The two activities are mechanistically different, but the rhodanese domain is important for both.
messages: Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln) (PubMed:27073879, PubMed:7520175). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA) (PubMed:7520175, PubMed:27073879). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain (Probable).
messages: It was also suggested that 2-thiourine geranylation and 2-thiouridine selenation in the tRNA chain may occur independently, in two distinc metabolic processes.
messages: Monomer.

99287:STM1434
gene id: 99287:STM1434
uniprot id: P66684
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

99287:STM2690
gene id: 99287:STM2690
uniprot id: Q8ZMV9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

99287:STM3719
gene id: 99287:STM3719
uniprot id: Q06994
names: Function
names: Similarity
messages: Adds a galactose goup to a glucose group of LPS.
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

99287:STM0796
gene id: 99287:STM0796
uniprot id: Q8ZQQ6
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

99287:STM0568
gene id: 99287:STM0568
uniprot id: Q8ZR53
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM3139
gene id: 99287:STM3139
uniprot id: Q7CPT1
names: Similarity
messages: In the C-terminal section; belongs to the glutathionylspermidine synthase preATP-grasp family.

99287:STM4028
gene id: 99287:STM4028
uniprot id: P58533
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

99287:STM0173
gene id: 99287:STM0173
uniprot id: Q8ZRR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

99287:STM2774
gene id: 99287:STM2774
uniprot id: Q8ZMN3
names: Subcellular Location Annotation
messages: Membrane

99287:STM2646
gene id: 99287:STM2646
uniprot id: Q7CQ05
names: Function
messages: Acts as a radical domain for damaged PFL and possibly other radical proteins.

99287:STM3150
gene id: 99287:STM3150
uniprot id: Q7CPS8
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

99287:STM1726
gene id: 99287:STM1726
uniprot id: P0A2K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

99287:STM3557
gene id: 99287:STM3557
uniprot id: Q7CPK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Binds G3P.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

99287:STM2080
gene id: 99287:STM2080
uniprot id: Q04873
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

99287:STM1982
gene id: 99287:STM1982
uniprot id: P54698
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RcsA family.
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes.
messages: Interacts with RcsB.

99287:STM3477
gene id: 99287:STM3477
uniprot id: P25924
names: Function
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the precorrin methyltransferase family.
messages: In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
messages: Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.

99287:STM3275
gene id: 99287:STM3275
uniprot id: Q8ZLT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiV subfamily.
messages: Forms an heterodimer with UbiU.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

99287:STM1918
gene id: 99287:STM1918
uniprot id: P07801
names: Function
messages: Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.

99287:STM2897
gene id: 99287:STM2897
uniprot id: P35671
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 T3SS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA. Positively regulates the secretion of SPI-1 T3SS effector proteins SipB, SipC and SipD and negatively influences the secretion of SipA, SopA and SptP.

99287:STM1240
gene id: 99287:STM1240
uniprot id: Q56032
names: Subcellular Location Annotation
messages: Cell membrane

99287:STM4397
gene id: 99287:STM4397
uniprot id: Q7CP91
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

99287:STM1844
gene id: 99287:STM1844
uniprot id: P65817
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane

99287:STM0651
gene id: 99287:STM0651
uniprot id: Q8ZQZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdgT transporter family.
messages: Catalyzes the proton-dependent uptake of 2-keto-3-deoxygluconate (KDG) into the cell.
messages: Cell inner membrane

99287:STM4226
gene id: 99287:STM4226
uniprot id: P0A279
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PsiE family.
messages: Cell inner membrane
messages: Expression is under the control of the two-component regulatory system PhoQ/PhoP.

99287:STM3959
gene id: 99287:STM3959
uniprot id: Q9L6N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rht family.
messages: Cell inner membrane
messages: Conducts the efflux of threonine.

99287:STM1380
gene id: 99287:STM1380
uniprot id: Q8ZPP7
names: Similarity
messages: Belongs to the peptidase S33 family.

99287:STM3391
gene id: 99287:STM3391
uniprot id: Q8ZLN4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

99287:STM0041
gene id: 99287:STM0041
uniprot id: Q8ZRZ2
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

99287:STM4185
gene id: 99287:STM4185
uniprot id: P51067
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AceK family.
messages: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
messages: Cytoplasm

99287:STM4159
gene id: 99287:STM4159
uniprot id: Q9S498
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. ThiH family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated cleavage of tyrosine to 2-iminoacetate and 4-cresol.
messages: Forms a heterodimer with ThiG.
messages: The product 2-iminoacetate hydrates in vitro to yield glyoxylate and ammonium.

99287:STM2457
gene id: 99287:STM2457
uniprot id: P19265
names: Biotechnology
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Artificial BMCs can be made in E.coli by expressing eutK, eutL, eutM, eutN, eutS (eutSMNLK) or eutS alone. Cargo proteins can be targeted to them using the first 19 residues of this protein. Beta-galactosidase (lacZ) was active within the BMC, showing the BMC allows passage of substrate into the interior. This can lead to the development of tailored BMCs for specific metabolic reactions.
messages: Bacterial microcompartment
messages: Belongs to the EutC family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds (Probable). It is spontaneously inactivated by its substrate and reactivated by EutA (By similarity). May play a role in bacterial microcompartment (BMC) assembly or maintenance (Probable). Directly targeted to the BMC (PubMed:22428024, PubMed:27063436, PubMed:27450681).
messages: Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase activity and to induce the operon. EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: No aerobic growth on ethanolamine (EA) supplemented with cobalamin (vitamin B12) (PubMed:10464203, PubMed:2656649). A non-polar deletion mutant does not grow on EA between pH 5.5 and pH 8.5 (PubMed:16585748). A deletion allows growth on acetate, suggesting BMC assembly or maintenance is impaired (PubMed:23585538).
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).
messages: The basic unit is a heterodimer which dimerizes to form tetramers (PubMed:1550360). The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards (Probable). Interacts with EutS, which targets it to the interior of the BMC (PubMed:22428024, PubMed:27063436, PubMed:27450681).
messages: The first 19 residues target foreign proteins (tested with eGFP, mCherry and lacZ) to the BMC both in situ and in E.coli. The cargo is only detected by Western blot in broken shells, strongly suggesting this protein is normally found inside the BMC and not on its exterior.

99287:STM0475
gene id: 99287:STM0475
uniprot id: Q8ZRA7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

99287:STM1382
gene id: 99287:STM1382
uniprot id: H9L428
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

99287:STM2755
gene id: 99287:STM2755
uniprot id: Q8ZMP9
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.

99287:STM2249
gene id: 99287:STM2249
uniprot id: Q8XGT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

99287:STM4181
gene id: 99287:STM4181
uniprot id: P40677
names: Function
names: Similarity
messages: Belongs to the acetyltransferase family.
messages: N-epsilon-lysine acetyltransferase that catalyzes acetylation of a large number of proteins.

99287:STM2084
gene id: 99287:STM2084
uniprot id: P26404
names: Function
names: Similarity
names: Subunit
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.
messages: Homodimer.
messages: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group B O antigen.

99287:STM0801
gene id: 99287:STM0801
uniprot id: P58586
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

99287:STM0719
gene id: 99287:STM0719
uniprot id: Q8ZQV4
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

99287:STM2364
gene id: 99287:STM2364
uniprot id: Q8ZNC1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedD family.
messages: Cell inner membrane
messages: Non-essential cell division protein that could be required for efficient cell constriction.
messages: The SPOR domain binds septal peptidoglycans and is required to target DedD to the septal ring.

99287:STM2264
gene id: 99287:STM2264
uniprot id: P37462
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the alkB family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents) (By similarity).

99287:STM3039
gene id: 99287:STM3039
uniprot id: Q8ZM82
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm
messages: Homodimer.

99287:STM3294
gene id: 99287:STM3294
uniprot id: Q7CPP9
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

99287:STM0433
gene id: 99287:STM0433
uniprot id: P55880
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peptidase C56 family.
messages: Cys-106 is easily oxidized to sulfinic acid.
messages: Homodimer.
messages: Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, collagen, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. However, is less efficient than Hsp31 and YhbO, suggesting that YajL might be preferentially dedicated to protein repair. Displays a covalent chaperone activity with sulfenylated thiol proteins by forming mixed disulfides with members of the thiol proteome, and preferentially with sulfenylated cellular proteins, upon oxidative stress; these mixed disulfides can be subsequently reduced by low-molecular-weight thiols to regenerate YajL and reduced proteins. Involved in biogenesis of ribosomal proteins, probably as a ribosomal protein-folding chaperone. Confers resistance to oxidative stress. Plays an important role in protection against electrophile/carbonyl stress. The chaperone activity reported for YajL is probably recruited to execute its deglycase activity, to interact with non-native glycated proteins and gain access to …

99287:STM4460
gene id: 99287:STM4460
uniprot id: P0A1Z4
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

99287:STM3958
gene id: 99287:STM3958
uniprot id: P40724
names: Function
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.
messages: Involved in the RecF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase.

99287:STM2119
gene id: 99287:STM2119
uniprot id: Q8ZNQ8
names: Similarity
messages: Belongs to the UPF0053 family.

99287:STM3091
gene id: 99287:STM3091
uniprot id: Q7CPT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell inner membrane
messages: Membrane

99287:STM3416
gene id: 99287:STM3416
uniprot id: O54297
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

99287:STM0088
gene id: 99287:STM0088
uniprot id: P0A1B1
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

99287:STM3792
gene id: 99287:STM3792
uniprot id: Q7CPF6
names: Subcellular Location Annotation
messages: Membrane

99287:STM3417
gene id: 99287:STM3417
uniprot id: O54296
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

99287:STM0643
gene id: 99287:STM0643
uniprot id: P39701
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family.
messages: Catalyzes the conversion of adenosylcobalamin 5'-phosphate to adenosylcobalamin (vitamin B12); involved in the assembly of the nucleotide loop of cobalamin. Also catalyzes the hydrolysis of the phospho group from alpha-ribazole 5'-phosphate to form alpha-ribazole.
messages: Monomer.

99287:STM1433
gene id: 99287:STM1433
uniprot id: Q7CQK9
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.
messages: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters.

99287:STM3625
gene id: 99287:STM3625
uniprot id: Q8ZLB3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM0832
gene id: 99287:STM0832
uniprot id: P0CL04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
messages: Cell inner membrane
messages: Involved in the efflux of threonine and homoserine.

99287:STM3846
gene id: 99287:STM3846
uniprot id: Q8ZKY2
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

99287:PSLT062
gene id: 99287:PSLT062
uniprot id: Q93GQ0
names: Similarity
messages: Belongs to the antirestriction protein family.

99287:STM1237
gene id: 99287:STM1237
uniprot id: Q8ZPZ1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.
messages: Responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA.

99287:STM0510
gene id: 99287:STM0510
uniprot id: Q9S4Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

99287:STM3153
gene id: 99287:STM3153
uniprot id: Q8ZM13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane

99287:STM3172
gene id: 99287:STM3172
uniprot id: P0A1C5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsP family.
messages: Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

99287:STM2162
gene id: 99287:STM2162
uniprot id: Q8ZNN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

99287:STM1714
gene id: 99287:STM1714
uniprot id: P0A2I1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

99287:STM0763
gene id: 99287:STM0763
uniprot id: Q8ZQS9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM0523
gene id: 99287:STM0523
uniprot id: Q7CR08
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
messages: Homotetramer.

99287:STM2922
gene id: 99287:STM2922
uniprot id: Q8ZMG0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the UbiD family. YclC subfamily.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives.

99287:STM3242
gene id: 99287:STM3242
uniprot id: O06961
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetokinase family. TdcD subfamily.
messages: Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor.
messages: Homodimer.

99287:STM4600
gene id: 99287:STM4600
uniprot id: Q8ZJT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

99287:STM3041
gene id: 99287:STM3041
uniprot id: P0A289
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2 (By similarity).
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
messages: The gene for this protein contains a UGA in-frame termination codon after Leu-25; a naturally occurring frameshift enables complete translation of RF-2. This provides a mechanism for the protein to regulate its own production.

99287:STM4347
gene id: 99287:STM4347
uniprot id: Q8ZKB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

99287:STM4081
gene id: 99287:STM4081
uniprot id: Q8ZKP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

99287:STM2809
gene id: 99287:STM2809
uniprot id: P17328
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Induced in response to increased extracellular osmolarity, this is the first gene of the proU operon (proV-proW-proX). Osmoregulation requires curved DNA downstream of the transcription start site in this gene, which is repressed when bound by H-NS. H-NS may act indirectly to influence the local topology of the promoter (PubMed:1423593).
messages: Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Probably responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (ProV), two transmembrane proteins (ProW) and a solute-binding protein (ProX).

99287:STM3585
gene id: 99287:STM3585
uniprot id: Q8ZLE1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM0026
gene id: 99287:STM0026
uniprot id: H9L4A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM0998
gene id: 99287:STM0998
uniprot id: P58661
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm
messages: Homodimer.

99287:STM1756
gene id: 99287:STM1756
uniprot id: Q8ZP42
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

99287:STM1751
gene id: 99287:STM1751
uniprot id: P0A1S2
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like protein H-NS family.
messages: Binds tightly to dsDNA (PubMed:10844682). Acts as a global transcriptional regulator through its ability to bind to AT-rich DNA sequences (PubMed:1423593, PubMed:16933988, PubMed:21673140). Binds in the minor groove of AT-rich DNA (PubMed:21673140). Was found to bind 746 genes, about half of which show no change in expression in disruption experiments suggesting these sites are important for nucleoid structure (PubMed:16933988). On a global level genes bound by H-NS are expressed at a lower than average level; H-NS is excluded from binding to highly transcribed genes and does not co-localize with RNA polymerase in DNA-binding studies during exponential growth in rich medium (PubMed:16933988). The best correlation for H-NS binding is AT-content rather than predicted DNA curvature (PubMed:16933988). Has a strong preference for DNA that has been recently acquired by horizontal gene transfer, binding strongly to Salmonella pathogenicity islands 1 and 2 (SPI1 and SPI2); this offers the selective advantage of silencing foreign DNA while keeping it in the genome in case of need (PubMed:16933988). DNA-binding influences plasmid DNA topology (PubMed:1423593). For the proU locus (the proV-proW-proX operon) inhibits transcription at low osmolarity by binding to AT-rich, curved, DNA downstream of the transcription start site of proV; repression is greater when more than 1 curved DNA sequence is present (PubMed:1423593). It plays a role in the thermal control of pili production (By similarity). It is subject to transcriptional auto-repression (By similarity). It binds preferentially to the upstream region of its own gene recognizing two segments of DNA on both sides of a bend centered around -150 (By similarity).
messages: Composed of 2 domains (approximately residues 1-64 and 89-136) joined by a flexible linker. The isolated N-terminus (1-64) forms a trimer, probably via coiled-coil interactions (PubMed:10844682, PubMed:11237622). The isolated N-terminus plus linker fragment (residues 1-89) forms homooligomers of increasing size with increasing protein concentration, while the isolated C-terminus fragment is a monomer (PubMed:10844682). A shorter fragment (residues 1-46) interacts with Hha (PubMed:23515315).
messages: Forms oligomers of increasing size with increasing protein concentration (PubMed:10844682, PubMed:23515315). The fragment of 1-83 probably forms oligomers of 4 dimeric units at 10 degrees Celsius, at 40 degrees Celsius only dimers are formed (PubMed:20798056). Binds Hha and YdgT (also known as cnu); crystal structures suggest each H-NS dimer could bind 2 Hha monomers on opposites sides (PubMed:23515315). Probably also binds StpA (By similarity).
messages: Loss of osmotic regulation of the proU locus, loss of changes in plasmid linking number (PubMed:1423593). 2X decreased growth rate, which is partially restored by a mutation preventing expression of SPI2, increased expression of about half of the genes to which H-NS binds (PubMed:16933988). Note strain LT2 has point mutation in rpoS which decreases its translation efficiency, in the presence of wild-type rpoS, deletion of hns is lethal (PubMed:16933988).
messages: nucleoid

99287:STM1954
gene id: 99287:STM1954
uniprot id: H9L419
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

99287:STM2956
gene id: 99287:STM2956
uniprot id: Q8ZME2
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

99287:STM1420
gene id: 99287:STM1420
uniprot id: P74891
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Part of a type III secretion system.

99287:STM2107
gene id: 99287:STM2107
uniprot id: Q9F7A2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Hydrolyzes GDP-mannose.

99287:STM2995
gene id: 99287:STM2995
uniprot id: Q8ZMB5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Binds 1 zinc ion per subunit.
messages: Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.
messages: Monomer.
messages: Periplasm

99287:STM4206
gene id: 99287:STM4206
uniprot id: Q8ZKJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gtrA family.
messages: Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane.
messages: Membrane

99287:STM1682
gene id: 99287:STM1682
uniprot id: Q8ZP65
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

99287:STM0961
gene id: 99287:STM0961
uniprot id: Q8ZQD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

99287:STM3382
gene id: 99287:STM3382
uniprot id: Q8ZLN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

99287:STM3743
gene id: 99287:STM3743
uniprot id: Q8ZL40
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM4023
gene id: 99287:STM4023
uniprot id: Q9L7S0
names: Function
names: Similarity
messages: Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily.
messages: Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1-sulfonate (DHPS).

99287:STM1461
gene id: 99287:STM1461
uniprot id: Q7CQK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hha/YmoA/Cnu family.
messages: Binds to H-NS and modified the range of genes it silences; H-NS alonge silences core gene while the H-NS-Hha complex (and presumably also H-NS-YdgT) silences genes acquired by horizontal gene transfer. Plays a role silencing virulence factors in the absence of factors that induce pathogenicity (By similarity). The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC (By similarity).
messages: Forms complexes with both H-NS (PubMed:23515315) and StpA (By similarity).

99287:STM3827
gene id: 99287:STM3827
uniprot id: Q8ZKZ2
names: Subcellular Location Annotation
messages: Membrane

99287:STM2768
gene id: 99287:STM2768
uniprot id: Q8ZMN6
names: Similarity
messages: Belongs to the transposase 8 family.

99287:STM1825
gene id: 99287:STM1825
uniprot id: P0A2K9
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

99287:STM3305
gene id: 99287:STM3305
uniprot id: Q7CPP6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

99287:STM2040
gene id: 99287:STM2040
uniprot id: P37450
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium (PubMed:10498708). By either propanediol or glycerol (PubMed:1312999).
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the diol/glycerol dehydratase large subunit family.
messages: Cells lacking this gene are defective in aerobic degradation of propanediol and display no propanediol dehydratase activity (PubMed:9023178). A triple pduC-pduD-pduE deletion releases no acetaldehyde when grown on propanediol (PubMed:16585748).
messages: Inhibited by glycerol.
messages: Part of the PduCDE complex that catalyzes the dehydration of 1,2-propanediol (1,2-PD) to propionaldehyde. Required for S.typhimurium growth on 1,2-PD as the sole carbon and energy source (Probable) (PubMed:9023178). This subunit is directly targeted to the BMC (By similarity).
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
messages: The propanediol dehydratase enzyme is a heterotrimeric complex composed of a large (PduC), a medium (PduD) and a small (PduE) subunit.

99287:STM4428
gene id: 99287:STM4428
uniprot id: Q8ZK55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. YfcJ family.
messages: Cell inner membrane

99287:STM2493
gene id: 99287:STM2493
uniprot id: Q7CQ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

99287:STM0357
gene id: 99287:STM0357
uniprot id: P40814
names: Function
names: Similarity
names: Subunit
messages: A beta subtype methylase that binds the system-specific DNA recognition site 5'-CAGAG-3' and methylates A-4 (of only 1 strand as the other does not have an A residue). DNA restriction requires both the Res and Mod subunits.
messages: Belongs to the N(4)/N(6)-methyltransferase family.
messages: Homodimer, also forms a functional restriction-competent complex with Res.

99287:STM2357
gene id: 99287:STM2357
uniprot id: Q8ZNC7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM2638
gene id: 99287:STM2638
uniprot id: H9L461
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RseB family.
messages: Periplasm

99287:STM0408
gene id: 99287:STM0408
uniprot id: Q7CR39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

99287:STM3986
gene id: 99287:STM3986
uniprot id: Q9L6L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA and requires TrkE for transport activity (By similarity).

99287:STM4122
gene id: 99287:STM4122
uniprot id: P63557
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm
messages: Homodimer.

99287:STM3051
gene id: 99287:STM3051
uniprot id: Q8ZM78
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

99287:STM0089
gene id: 99287:STM0089
uniprot id: Q56017
names: Function
messages: Not known; mutations in apaG/corD give a phenotype of low-level Co(2+) resistance. They also decrease Mg(2+) efflux but not influx via the CorA Mg(2+) transport system.

99287:STM2805
gene id: 99287:STM2805
uniprot id: Q56108
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

99287:STM3856
gene id: 99287:STM3856
uniprot id: Q7CPE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

99287:STM3994
gene id: 99287:STM3994
uniprot id: Q8ZKU9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

99287:STM3143
gene id: 99287:STM3143
uniprot id: Q7CPT0
names: Similarity
messages: Belongs to the HupF/HypC family.

99287:STM3165
gene id: 99287:STM3165
uniprot id: Q8ZM06
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2-keto-L-gulonic acid is a key intermediate in the production of L-ascorbic acid (vitamin C).
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
messages: Cytoplasm
messages: Monomer.

99287:STM4512
gene id: 99287:STM4512
uniprot id: Q8ZJZ8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M38 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two zinc ions.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.
messages: Cytoplasm

99287:STM1219
gene id: 99287:STM1219
uniprot id: Q8ZQ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

99287:STM1754
gene id: 99287:STM1754
uniprot id: Q8ZP44
names: Caution
names: Similarity
messages: Belongs to the NTE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM0517
gene id: 99287:STM0517
uniprot id: Q8ZR85
names: Similarity
messages: Belongs to the TPP enzyme family.

99287:STM3113
gene id: 99287:STM3113
uniprot id: Q8ZM38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family.
messages: Broad-specificity transporter of purine and pyrimidine nucleosides. Transport is driven by a proton motive force.
messages: Cell inner membrane
messages: Membrane

99287:STM3596
gene id: 99287:STM3596
uniprot id: Q7CPJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

99287:STM0463
gene id: 99287:STM0463
uniprot id: Q7CR19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

99287:STM2570
gene id: 99287:STM2570
uniprot id: Q8ZN26
names: Subcellular Location Annotation
messages: Membrane

99287:STM1094
gene id: 99287:STM1094
uniprot id: Q8ZQ55
names: Similarity
messages: Belongs to the peptidase C69 family.

99287:STM0352
gene id: 99287:STM0352
uniprot id: Q8ZRG8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

99287:STM0330
gene id: 99287:STM0330
uniprot id: Q8ZRI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

99287:STM3985
gene id: 99287:STM3985
uniprot id: Q9L6L3
names: Similarity
messages: Belongs to the IMPACT family.

99287:STM0514
gene id: 99287:STM0514
uniprot id: Q9S4Y7
names: Function
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.
messages: Positive regulator essential for the expression of allD operon. Binds to the allD promoter (By similarity).

99287:STM0888
gene id: 99287:STM0888
uniprot id: Q8ZQJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

99287:STM3841
gene id: 99287:STM3841
uniprot id: P0A8C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

99287:STM0503
gene id: 99287:STM0503
uniprot id: Q8XEU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

99287:STM2033
gene id: 99287:STM2033
uniprot id: Q05601
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobH/CbiC family.
messages: Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate.
messages: Homodimer.

99287:STM2265
gene id: 99287:STM2265
uniprot id: P26189
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus. It activates the transcription of alkA, alkB and aidB.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

99287:STM3947
gene id: 99287:STM3947
uniprot id: P0A1F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

99287:STM2272
gene id: 99287:STM2272
uniprot id: P37411
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Replenishes negative supercoiling downstream of highly transcribed genes to help control overall chromosomal supercoiling density (PubMed:22916023). E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB subunit is toxic in E.coli, while the E.coli copy can be expressed in S.typhimurium even though the 2 subunits have 777/804 residues identical (PubMed:17400739).
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
messages: Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

99287:STM3960
gene id: 99287:STM3960
uniprot id: Q9L6N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rht family.
messages: Cell membrane
messages: Conducts the efflux of homoserine and homoserine lactone.

99287:STM4546
gene id: 99287:STM4546
uniprot id: Q8ZJX3
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

99287:STM2048
gene id: 99287:STM2048
uniprot id: Q9XDN4
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the PduM family.
messages: Impaired for BMC assembly, with a disrupted, unstable BMC shell.
messages: Interacts with shell protein PduK.
messages: Plays an essential role in assembly and/or stability of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. Overexpression impairs BMC formation.
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.

99287:STM0222
gene id: 99287:STM0222
uniprot id: Q7CR63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

99287:STM3442
gene id: 99287:STM3442
uniprot id: O68927
names: Similarity
messages: Belongs to the peptidase A24 family.

99287:STM4558
gene id: 99287:STM4558
uniprot id: Q8ZJW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

99287:STM3174
gene id: 99287:STM3174
uniprot id: P26973
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:22916023). Performs the decatenation events required during the replication of a circular DNA molecule.

99287:STM4324
gene id: 99287:STM4324
uniprot id: Q7CPA2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CutA family.
messages: Binds 1 copper ion per subunit.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in resistance toward heavy metals.

99287:STM3306
gene id: 99287:STM3306
uniprot id: H9L4B3
names: Similarity
messages: Belongs to the ner transcriptional regulatory family.

99287:STM3090
gene id: 99287:STM3090
uniprot id: P66764
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

99287:STM0756
gene id: 99287:STM0756
uniprot id: P24519
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm
messages: Repressed by NadR and partially controlled by cAMP.

99287:STM3975
gene id: 99287:STM3975
uniprot id: Q7CPD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

99287:STM2807
gene id: 99287:STM2807
uniprot id: Q08698
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1E contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide.
messages: Tetramer of two alpha and two beta subunits.
messages: Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Lacks the N-terminal activity site.

99287:STM1324
gene id: 99287:STM1324
uniprot id: Q7CQN8
names: Similarity
messages: Belongs to the fructosamine kinase family.

99287:STM3699
gene id: 99287:STM3699
uniprot id: P29847
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Part of the cysteine synthase complex formed at a ratio of 1 copy of this protein and 2 copies of O-acetylserine sulfhydrylase (cysK). The complex reversibly dissociates in the presence of O-acetyl-L-serine in the absence of hydrogen sulfide.
messages: Sensitive to feedback inhibition by L-cysteine.

99287:STM3415
gene id: 99287:STM3415
uniprot id: P0A7Z7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription (By similarity).
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

99287:STM4262
gene id: 99287:STM4262
uniprot id: Q8ZKG5
names: Subcellular Location Annotation
messages: Membrane

99287:STM1224
gene id: 99287:STM1224
uniprot id: Q56061
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Sif family.
messages: Cells lacking this gene do not produce Sifs in epithelial cells and show attenuated virulence in mice.
messages: Domains throughout the protein, and not only the N-terminus, are required for secretion and translocation. Both N- and C-terminal domains are also required for formation of tubules.
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.
messages: Host cell membrane
messages: Host cytoplasm
messages: Interacts with host PLEKHM2. Interacts with SseJ; the interaction is indirect.
messages: Secreted

99287:STM2644
gene id: 99287:STM2644
uniprot id: Q8ZMX6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM0449
gene id: 99287:STM0449
uniprot id: Q8ZRC0
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

99287:STM4104
gene id: 99287:STM4104
uniprot id: Q8ZKN1
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

99287:STM3312
gene id: 99287:STM3312
uniprot id: Q7CPP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

99287:STM2949
gene id: 99287:STM2949
uniprot id: Q7CPW5
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

99287:STM3380
gene id: 99287:STM3380
uniprot id: Q7CPM0
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

99287:STM1598
gene id: 99287:STM1598
uniprot id: Q8ZPC8
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

99287:STM3899
gene id: 99287:STM3899
uniprot id: P57015
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

99287:STM2176
gene id: 99287:STM2176
uniprot id: Q8ZNM2
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

99287:STM2670
gene id: 99287:STM2670
uniprot id: P0A1B5
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
messages: There are 3 DAHP synthases, AroF is feedback-inhibited by Tyr. The other 2 DAHP synthases are Phe- and Trp-sensitive, respectively.

99287:STM2187
gene id: 99287:STM2187
uniprot id: Q8ZNL7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotetramer of 2 PreA and 2 PreT subunits.
messages: Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT) (By similarity).

99287:STM2266
gene id: 99287:STM2266
uniprot id: P41780
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Cells lacking this gene are conditional thiamine auxotrophs, and display phenotypic behaviors similar to those of strains lacking isc (iron-sulfur [Fe-S] cluster biosynthesis) operon functions.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein such as NqrB and NqrC, two subunits of the NQR complex.
messages: Homodimer.
messages: Was originally thought to be involved in synthesis of the pyrimidine moiety of thiamine and/or in metabolism of Fe-S clusters.

99287:STM0091
gene id: 99287:STM0091
uniprot id: P58717
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can probably use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

99287:STM2092
gene id: 99287:STM2092
uniprot id: P26396
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glucose-1-phosphate cytidylyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalysis proceeds via a sequential rather than a ping-pong bi-bi reaction mechanism.
messages: Homohexamer.
messages: Involved in the biosynthesis of the tyvelose, a 3,6-dideoxyhexose found in the O-antigen of the surface lipopolysaccharides. It catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate (By similarity).

99287:STM3118
gene id: 99287:STM3118
uniprot id: Q93DX1
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

99287:STM0242
gene id: 99287:STM0242
uniprot id: Q7CR62
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

99287:STM2432
gene id: 99287:STM2432
uniprot id: P0A249
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
messages: Homodimer.
messages: The N-terminal domain contains the HPr binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site.
messages: The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain.

99287:STM0214
gene id: 99287:STM0214
uniprot id: P23679
names: Activity Regulation
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

99287:STM1187
gene id: 99287:STM1187
uniprot id: Q8ZQ16
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.

99287:STM1174
gene id: 99287:STM1174
uniprot id: P16437
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Defects in flagellar assembly process.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod. In Gram-negative bacteria, at least four rings, L, P, S and M are present, whereas Gram-positive bacteria lack the L and P rings. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF build up the proximal portion of the rod with about 6 subunits each. Rod assembly occurs by export via the flagellum-specific pathway of its constituent proteins and by their incorporation into the rod structure in the probable order of FlgB, FlgC, FlgF and FlgG. Another protein, FliE, also assembles onto the stable rod structure. Interacts with FliE and peptidoglycan hydrolase FlgJ (via N-terminus), which seems to function as a scaffold or cap for rod assembly.

99287:STM3475
gene id: 99287:STM3475
uniprot id: P0A229
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with NirB.
messages: Cytoplasm
messages: Required for activity of the reductase.

99287:STM0405
gene id: 99287:STM0405
uniprot id: Q8ZRD8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

99287:STM0630
gene id: 99287:STM0630
uniprot id: P63866
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

99287:STM1222
gene id: 99287:STM1222
uniprot id: P0A2C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein.

99287:STM0145
gene id: 99287:STM0145
uniprot id: P30012
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers (By similarity). Homodimer.
messages: Involved in the catabolism of quinolinic acid (QA).

99287:STM2751
gene id: 99287:STM2751
uniprot id: Q8ZMQ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM1102
gene id: 99287:STM1102
uniprot id: Q8ZQ48
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

99287:STM3424
gene id: 99287:STM3424
uniprot id: Q7CPL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

99287:STM0744
gene id: 99287:STM0744
uniprot id: Q8ZQT7
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

99287:STM3043
gene id: 99287:STM3043
uniprot id: P55890
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Homodimer.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase.

99287:STM0889
gene id: 99287:STM0889
uniprot id: Q7CQV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

99287:STM0399
gene id: 99287:STM0399
uniprot id: P0A1W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Cell inner membrane
messages: Liv-II branched chain amino acid transport system, which transports leucine, valine and isoleucine.

99287:STM2539
gene id: 99287:STM2539
uniprot id: Q8ZN42
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU.

99287:STM4298
gene id: 99287:STM4298
uniprot id: P30877
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Binds 1 NAD(+) per subunit.
messages: Homodimer.

99287:STM0891
gene id: 99287:STM0891
uniprot id: Q7CQV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

99287:STM3226
gene id: 99287:STM3226
uniprot id: Q8ZLX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell inner membrane
messages: Membrane

99287:STM3279
gene id: 99287:STM3279
uniprot id: Q8ZLT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
messages: Cell inner membrane
messages: Involved in transporting aromatic amino acids across the cytoplasmic membrane.
messages: Membrane

99287:STM1703
gene id: 99287:STM1703
uniprot id: Q8ZP53
names: Similarity
names: Subunit
messages: Belongs to the YdiV family.
messages: Interacts with FlhD in the FlhC(2)FlhD(4) heterohexamer, inhibiting its ability to activate transcription.

99287:STM2371
gene id: 99287:STM2371
uniprot id: Q7CQ37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion (T3S) system. Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB.
messages: Belongs to the flk family.
messages: Cell inner membrane

99287:STM2549
gene id: 99287:STM2549
uniprot id: P26475
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: By sulfite. Repressed by oxygen.
messages: Cytoplasm
messages: The anaerobic sulfite reductase seems to consist of three subunits.
messages: This enzyme catalyzes the hydrogen sulfide production from sulfite. It is strictly anaerobic. It is regulated by electron acceptors rather than by cysteine.

99287:STM4340
gene id: 99287:STM4340
uniprot id: P67645
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FrdD family.
messages: Cell inner membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).
messages: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.

99287:STM0704
gene id: 99287:STM0704
uniprot id: Q8ZQW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

99287:STM3837
gene id: 99287:STM3837
uniprot id: P26464
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.

99287:STM3501
gene id: 99287:STM3501
uniprot id: P08982
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated.
messages: Cell inner membrane
messages: Has several major domains; the N-terminal cytoplasmic domain is followed by 2 transmembrane helices that anchor the protein in the membrane; the periplasmic domain between the helices interacts with MrzA. The cytoplasmic C-terminal domain has a HAMP domain joined by a flexible linker to a histidine kinase domain. The HAMP domain by itself is intrinsically disordered. The cytoplasmic dimerization domain (CDD) forms an osmosensitive core and includes the autophosphorylated histidine residue.
messages: Homodimer.
messages: Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (By similarity). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals; at low osmolarity OmpR activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (By similarity).

99287:STM4131
gene id: 99287:STM4131
uniprot id: P40723
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

99287:STM0096
gene id: 99287:STM0096
uniprot id: Q8ZRV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
messages: Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.
messages: Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.

99287:STM2996
gene id: 99287:STM2996
uniprot id: Q8ZMB4
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

99287:STM0396
gene id: 99287:STM0396
uniprot id: Q8ZRE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

99287:STM1992
gene id: 99287:STM1992
uniprot id: Q8ZNT0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

99287:STM4592
gene id: 99287:STM4592
uniprot id: Q8ZJU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM3510
gene id: 99287:STM3510
uniprot id: Q8ZLI8
names: Function
names: Similarity
messages: Belongs to the ComF/GntX family.
messages: Could be involved in gluconate metabolism.

99287:STM2190
gene id: 99287:STM2190
uniprot id: P23905
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import (By similarity). In addition, binds D-galactose and D-glucose and plays a role in the chemotaxis towards these two sugars by interacting with the Trg chemoreceptor (Probable).
messages: Periplasm
messages: The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).
messages: The calcium-binding site is structurally similar to that of EF-hand proteins, but is in two parts, with the last calcium ligand provided by Glu-228.

99287:STM3095
gene id: 99287:STM3095
uniprot id: P58580
names: Cofactor
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

99287:STM0830
gene id: 99287:STM0830
uniprot id: Q7CQW0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

99287:STM2379
gene id: 99287:STM2379
uniprot id: Q8ZNB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the DAO family.
messages: In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.

99287:STM4182
gene id: 99287:STM4182
uniprot id: P37413
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

99287:STM0697
gene id: 99287:STM0697
uniprot id: Q7CQY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SeqA family.
messages: Cytoplasm
messages: Homodimer. Polymerizes to form helical filaments.
messages: Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.

99287:STM2081
gene id: 99287:STM2081
uniprot id: P14062
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

99287:STM4355
gene id: 99287:STM4355
uniprot id: Q8ZKA8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Monomer.

99287:STM3495
gene id: 99287:STM3495
uniprot id: P0CL13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IgaA family.
messages: Cell inner membrane
messages: Involved in negative control of bacterial proliferation within fibroblasts.

99287:STM3181
gene id: 99287:STM3181
uniprot id: P0A2I5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:22916023). Performs the decatenation events required during the replication of a circular DNA molecule.

99287:STM2440
gene id: 99287:STM2440
uniprot id: P29848
names: Function
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product.

99287:STM1693
gene id: 99287:STM1693
uniprot id: P0A2J3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
messages: Cell inner membrane
messages: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides.
messages: Part of the sapA-sapB-sapC-sapD-sapF operon, RNA detected in mid-log phase cells.

99287:STM2370
gene id: 99287:STM2370
uniprot id: P60802
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
messages: Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
messages: Cytoplasm
messages: Homodimer.

99287:STM2951
gene id: 99287:STM2951
uniprot id: Q7CPW4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM3799
gene id: 99287:STM3799
uniprot id: Q8ZL11
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

99287:STM4256
gene id: 99287:STM4256
uniprot id: P0A2F6
names: Function
names: Subunit
messages: Homotetramer.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

99287:STM2252
gene id: 99287:STM2252
uniprot id: Q8XGY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

99287:STM3028
gene id: 99287:STM3028
uniprot id: Q8ZM90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

99287:STM0418
gene id: 99287:STM0418
uniprot id: Q8ZRD3
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

99287:STM3668
gene id: 99287:STM3668
uniprot id: Q8ZL83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.
messages: Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
messages: Cytoplasm
messages: Homodimer.

99287:STM2270
gene id: 99287:STM2270
uniprot id: P58663
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the RcsB family.
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner.
messages: Interacts with RcsD and RcsA.
messages: Phosphorylated and activated by RcsD.

99287:STM0979
gene id: 99287:STM0979
uniprot id: Q8ZQC5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

99287:STM3386
gene id: 99287:STM3386
uniprot id: Q7CPL9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

99287:STM3563
gene id: 99287:STM3563
uniprot id: P0A2J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily.
messages: Cell inner membrane
messages: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.

99287:STM0829
gene id: 99287:STM0829
uniprot id: Q7CQW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

99287:STM3640
gene id: 99287:STM3640
uniprot id: P43660
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM0430
gene id: 99287:STM0430
uniprot id: Q7CR30
names: Induction
names: Miscellaneous
messages: Induced when inorganic phosphate is limiting; this is controlled by PhoB.
messages: Maps to a phosphate-starvation-inducible locus previously known as PsiC.

99287:STM4189
gene id: 99287:STM4189
uniprot id: P40730
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To B.subtilis YqeW.

99287:STM3974
gene id: 99287:STM3974
uniprot id: P57048
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

99287:STM1264
gene id: 99287:STM1264
uniprot id: Q8ZPX9
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Subunit
messages: Has an N-terminal adenylyltranferase and a C-terminal helical domain, with an ATP-binding cleft between them (PubMed:26527143, PubMed:29871922). Upon ATP binding the two domains reposition, antibiotics bind in this cleft (PubMed:29871922).
messages: Induced by growth in minimal media (at protein level). Under positive control of the stringent response regulator guanosine 3',5'-bis(diphosphate) (ppGpp).
messages: Loss of streptomycin and spectinomycin resistance.
messages: Mediates bacterial resistance to the antibiotics streptomycin and spectinomycin, does not confer resistance to kanamycin (PubMed:26527143). Binds ATP first, then antibiotic (PubMed:26527143, PubMed:29871922).
messages: Monomer.

99287:STM3878
gene id: 99287:STM3878
uniprot id: Q8ZKW3
names: Similarity
names: Subunit
messages: Belongs to the ViaA family.
messages: Possible formation of a ternary complex RavA-ViaA-CadA.

99287:STM3771
gene id: 99287:STM3771
uniprot id: Q7CPG3
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM0221
gene id: 99287:STM0221
uniprot id: Q8ZRP2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
messages: Homodimer.

99287:STM2239
gene id: 99287:STM2239
uniprot id: Q8ZNI6
names: Similarity
messages: Belongs to the phage antitermination Q type 1 family.

99287:STM1806
gene id: 99287:STM1806
uniprot id: Q8ZP14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
messages: Cell inner membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

99287:STM3255
gene id: 99287:STM3255
uniprot id: Q8ZLV3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM3848
gene id: 99287:STM3848
uniprot id: Q8ZKY0
names: Function
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.
messages: Involved in anaerobic NO protection.

99287:STM1968
gene id: 99287:STM1968
uniprot id: P26462
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

99287:STM2532
gene id: 99287:STM2532
uniprot id: Q8ZN46
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
messages: Protects the bacterial cell from host peptidases.

99287:STM2915
gene id: 99287:STM2915
uniprot id: Q8ZMG6
names: Similarity
messages: Belongs to the hyi family.

99287:STM3425
gene id: 99287:STM3425
uniprot id: P66313
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

99287:STM0154
gene id: 99287:STM0154
uniprot id: Q8ZRT0
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

99287:STM3297
gene id: 99287:STM3297
uniprot id: Q8ZLS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

99287:STM1522
gene id: 99287:STM1522
uniprot id: P58531
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
messages: Cell inner membrane
messages: Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.

99287:STM0847
gene id: 99287:STM0847
uniprot id: Q7CQV5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autocleaved. Generates the alpha and beta subunits. The beta subunit is thought to be responsible for the nucleophile hydrolase activity.
messages: Belongs to the Ntn-hydrolase family.
messages: Degrades proteins damaged by L-isoaspartyl residue formation (also known as beta-Asp residues). Degrades L-isoaspartyl-containing di- and tripeptides. Acts best on iso-Asp-Leu, followed by iso-Asp-Ala, -His and to a lesser extent iso-Asp-Lys, -Phe and iso-Asp-Leu-Ala. Does not act on internal iso-Asp bonds (Als-iso-Asp-Leu-Ala). Does not act on alpha-Asp bonds. Has poor L-asparaginase activity.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.

99287:STM3482
gene id: 99287:STM3482
uniprot id: Q8ZLK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Monomer.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

99287:STM0124
gene id: 99287:STM0124
uniprot id: Q8ZRU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

99287:STM2296
gene id: 99287:STM2296
uniprot id: Q8ZNF4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoglycerate mutase family. Ais subfamily.
messages: Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance.
messages: Induced by BasR.
messages: Periplasm

99287:STM2342
gene id: 99287:STM2342
uniprot id: Q8ZND3
names: Subcellular Location Annotation
messages: Membrane

99287:STM0063
gene id: 99287:STM0063
uniprot id: Q8ZRX9
names: Similarity
messages: Belongs to the CitG/MdcB family.

99287:STM4580
gene id: 99287:STM4580
uniprot id: P24518
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Feed-back regulated by NAD. A high level of NAD causes NadR to lose enzymatic activity and repress several NAD synthetic genes; conversely, a low NAD level activates the assimilatory enzymatic activities and leads to derepression of biosynthetic genes.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the bacterial RNK family.
messages: In the central section; belongs to the bacterial NMN adenylyltransferase family.
messages: This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD(+). The NMN adenylyltransferase domain also functions as the NAD and ATP sensor.

99287:STM3775
gene id: 99287:STM3775
uniprot id: Q8ZL24
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

99287:STM2122
gene id: 99287:STM2122
uniprot id: P67408
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

99287:STM2435
gene id: 99287:STM2435
uniprot id: P40192
names: Function
names: Induction
names: Similarity
names: Subunit
messages: B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP.
messages: Belongs to the pyridoxine kinase family. PdxK subfamily.
messages: Homodimer.
messages: Is repressed by the transcriptional regulator PtsJ.

99287:STM1394
gene id: 99287:STM1394
uniprot id: H9L495
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial secretin family. T3SS SctC subfamily.
messages: Cell outer membrane
messages: Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane.
messages: Membrane
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle. This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope. Forms a stable homooligomeric complex.

99287:STM1480
gene id: 99287:STM1480
uniprot id: Q7CQK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

99287:STM0087
gene id: 99287:STM0087
uniprot id: Q8ZRW1
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

99287:STM4289
gene id: 99287:STM4289
uniprot id: Q7CPA4
names: Similarity
messages: Belongs to the YjdM family.

99287:STM4333
gene id: 99287:STM4333
uniprot id: Q8ZKB8
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cells lacking this gene are highly attenuated for virulence in mouse models of infection. Salmonella epmA and epmB mutants share extensive phenotypic pleiotropy, including an increased ability to respire under nutrient-limiting conditions, hypersusceptibility to a variety of diverse growth inhibitors, and altered expression of multiple proteins, including several encoded on the SPI-1 pathogenicity island.
messages: With EpmA is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. EpmB appears to act before EpmA. Displays lysine 2,3-aminomutase activity, producing (R)-beta-lysine from (S)-alpha-lysine (L-lysine) (By similarity).

99287:STM4110
gene id: 99287:STM4110
uniprot id: Q8ZKM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

99287:STM3070
gene id: 99287:STM3070
uniprot id: Q7CPU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
messages: Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
messages: Cytoplasm
messages: Homotetramer.

99287:STM2051
gene id: 99287:STM2051
uniprot id: Q9XDN1
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A CoA-acylating aldehyde dehydrogenase required for optimal 1,2-propanediol (1,2-PD) degradation (PubMed:14504694, PubMed:20308536). Optimizes growth in the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by minimizing propionaldehyde toxicity (Probable). Directly targeted to the BMC (PubMed:20308536, PubMed:22927404, PubMed:26283792). NAD(+) and NADH are regenerated internally within the Pdu BMC by the PduP and PduQ enzymes, which reduce NAD(+) and oxidize NADH respectively, although there must also be cofactor transport across the BMC (PubMed:23077559).
messages: A short N-terminal, probably helical sequence targets this enzyme and foreign proteins (tested with GST, MBP and eGFP) to the BMC. 10 residues give poor localization while 14 is better and 18 is better yet. The cargo is only detected by Western blot in broken shells, strongly suggesting this protein is normally found inside the BMC and not on its exterior (PubMed:20308536, PubMed:22927404, PubMed:26283792). This N-terminal sequence interacts with the C-terminus of PduA, and possibly also with PduJ, to encapsulate PduP into BMCs (PubMed:22927404). PduD and PduP compete for encapsulation in BMCs (PubMed:26283792).
messages: BMC production is induced by growth on 1,2-PD vitamin B12 medium.
messages: Bacterial microcompartment
messages: Bacterial microcompartments (BMC) 100-200 nm in cross section are formed during aerobic growth on minimal 1,2-PD-B12 or anaerobic growth on 1,2-PD-tetrathionate medium, but not during aerobic growth on glucose, anerobic growth on glucose or pyruvate-tetrathionate (PubMed:10498708). BMCs can constitute up to 10% of total cell protein (PubMed:12923081).
messages: Belongs to the EutE/PduP family.
messages: Interacts with BMC shell proteins PduA and PduJ, which target this protein to BMC (PubMed:22927404). Interacts with PduQ, probably via the N-terminus of PduQ (PubMed:23077559). Interacts with PduK, probably with its BMC-containing N-terminus (By similarity).
messages: Significantly impaired for growth on 1,2-PD/CN-B12, loss of propionaldehyde dehydrogenase activity (PubMed:14504694). Releases decreased amounts of acetaldehyde when grown on propanediol (PubMed:16585748).
messages: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.

99287:STM4042
gene id: 99287:STM4042
uniprot id: Q7CPC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

99287:STM3868
gene id: 99287:STM3868
uniprot id: Q7CPE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

99287:STM1142
gene id: 99287:STM1142
uniprot id: O54294
names: Function
messages: Necessary for transcription of the csgAB operon. May have the capability to respond to starvation and/or high cell density by activating csgBA transcription (By similarity).

99287:STM3949
gene id: 99287:STM3949
uniprot id: P55888
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.
messages: FtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges the top DNA strands.

99287:STM1724
gene id: 99287:STM1724
uniprot id: P00905
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Cooperatively feedback inhibited by tryptophan.
messages: In the C-terminal section; belongs to the anthranilate phosphoribosyltransferase family.
messages: Monomer. Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE) (Probable).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. In addition to synthesizing anthranilate, it also catalyzes the second step of the pathway, the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate.

99287:STM3728
gene id: 99287:STM3728
uniprot id: P0A2A5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

99287:STM0972
gene id: 99287:STM0972
uniprot id: Q8ZQC8
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SopD family.
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Contributes to the formation of Salmonella-induced filaments (Sifs) in infected epithelial cells and to replication in macrophages.
messages: Host cell membrane
messages: Mutation leads to a prolonged survival of infected mice. Deletion blocks Sifs formation at an intermediate stage, before fusion of late endosome compartments with the SCV, and impairs bacterial replication in mouse macrophages but not in human epithelial cells.
messages: Secreted
messages: The N-terminal domain mediates secretion by SPI-2 T3SS and targeting of late endocytic compartments in host cells.
messages: Transcription is induced inside host cells and is dependent on the SsrA/SsrB and PhoP/PhoQ two-component systems.

99287:STM4305
gene id: 99287:STM4305
uniprot id: Q8ZKD7
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

99287:STM3839
gene id: 99287:STM3839
uniprot id: P0A7P8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

99287:STM2072
gene id: 99287:STM2072
uniprot id: P10370
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Activity is lost when the metal is removed through urea denaturation or chelation, and can be regained by addition of metal.
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit. At high pH manganese can replace zinc.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Homodimer.
messages: PubMed:3533140 originally reported Cys-117 to be the active site. PubMed:8314784 has shown this to be wrong.

99287:STM0308
gene id: 99287:STM0308
uniprot id: Q8ZRJ8
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

99287:STM3186
gene id: 99287:STM3186
uniprot id: Q8ZLZ4
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

99287:STM4371
gene id: 99287:STM4371
uniprot id: Q8ZKA0
names: Similarity
messages: Belongs to the PspA/IM30 family.

99287:STM1156
gene id: 99287:STM1156
uniprot id: Q8ZQ23
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

99287:STM3220
gene id: 99287:STM3220
uniprot id: Q8ZLX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmG family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.

99287:STM3972
gene id: 99287:STM3972
uniprot id: P0A197
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell inner membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.

99287:STM0748
gene id: 99287:STM0748
uniprot id: Q8ZQT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

99287:STM0422
gene id: 99287:STM0422
uniprot id: Q8ZRD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

99287:STM0584
gene id: 99287:STM0584
uniprot id: Q56064
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P-Pant transferase superfamily. EntD family.
messages: EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase.
messages: Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo-domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively.
messages: Membrane

99287:STM1734
gene id: 99287:STM1734
uniprot id: Q8ZP49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0259 family.
messages: Cell inner membrane

99287:STM0518
gene id: 99287:STM0518
uniprot id: Q8ZR84
names: Similarity
messages: Belongs to the hyi family.

99287:STM3314
gene id: 99287:STM3314
uniprot id: Q8ZLS2
names: Subcellular Location Annotation
messages: Membrane

99287:STM2127
gene id: 99287:STM2127
uniprot id: Q8ZNQ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
messages: Cell inner membrane
messages: Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC.

99287:STM0046
gene id: 99287:STM0046
uniprot id: Q8ZRZ0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

99287:STM2474
gene id: 99287:STM2474
uniprot id: Q8ZN82
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

99287:STM0781
gene id: 99287:STM0781
uniprot id: Q8ZQR7
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

99287:STM2652
gene id: 99287:STM2652
uniprot id: Q7CQ03
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.

99287:STM2581
gene id: 99287:STM2581
uniprot id: Q56056
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accumulation of full-length 23S rRNA as well as larger precursor rRNA transcripts. Strain grows slower than wild-type.
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of ribosomal RNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Removes small helical intervening sequences (IVSs) from all 7 of the 23S rRNA transcripts. Probably also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Probably processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.
messages: This organism contains small helical (90-110 nucleotide) intervening sequences (IVSs) in all 7 23S rRNA genes at either the 550-bp or 1170-bp positions or both, accumulating the 23S rRNA as 2.4, 1.7, 1.6, 0.7, and 0.5 kb pieces.

99287:STM2870
gene id: 99287:STM2870
uniprot id: P0CL44
names: Function
messages: Oxygen-regulated protein required for bacterial internalization.

99287:STM1483
gene id: 99287:STM1483
uniprot id: Q7CQK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI subfamily.
messages: Catalyzes the excretion of spermidine.
messages: Cell inner membrane
messages: Forms a complex with MdtJ.

99287:STM0027
gene id: 99287:STM0027
uniprot id: Q8ZS04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

99287:STM0569
gene id: 99287:STM0569
uniprot id: Q8ZR52
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

99287:STM3444
gene id: 99287:STM3444
uniprot id: P0A1Z6
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [2Fe-2S] cluster.
messages: Monomer.
messages: Seems to associate with BFR; could be a general redox and/or regulatory component participating in the iron storage mobilization functions of BFR. Could participate in the release or the delivery of iron from/to bacterioferritin (or other iron complexes) (By similarity).

99287:STM1570
gene id: 99287:STM1570
uniprot id: Q8ZPE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Periplasm

99287:STM3507
gene id: 99287:STM3507
uniprot id: Q7CPK5
names: Function
names: Similarity
messages: Belongs to the FeoC family.
messages: May function as a transcriptional regulator that controls feoABC expression.

99287:STM0388
gene id: 99287:STM0388
uniprot id: P63603
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family. AroL subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.
messages: The LID domain closes over the active site upon ATP binding.

99287:STM1456
gene id: 99287:STM1456
uniprot id: Q8ZPM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.
messages: The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.

99287:STM3517
gene id: 99287:STM3517
uniprot id: Q8ZLI1
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

99287:STM4092
gene id: 99287:STM4092
uniprot id: P0A271
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: By heat shock.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

99287:STM4358
gene id: 99287:STM4358
uniprot id: P26366
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.
messages: Cell-wall hydrolase involved in septum cleavage during cell division.
messages: Periplasm

99287:STM3219
gene id: 99287:STM3219
uniprot id: Q8ZLX6
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

99287:STM4061
gene id: 99287:STM4061
uniprot id: Q8ZKR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
messages: Cell inner membrane
messages: Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+). May be involved in zinc and iron detoxification by efflux.
messages: Homodimer.

99287:STM1809
gene id: 99287:STM1809
uniprot id: P64267
names: Similarity
messages: Belongs to the gns family.

99287:STM2420
gene id: 99287:STM2420
uniprot id: Q8ZN96
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM3965
gene id: 99287:STM3965
uniprot id: Q9L6N1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

99287:STM3529
gene id: 99287:STM3529
uniprot id: Q8ZLH1
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

99287:STM0647
gene id: 99287:STM0647
uniprot id: Q8ZQZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

99287:STM0217
gene id: 99287:STM0217
uniprot id: P64052
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

99287:STM4573
gene id: 99287:STM4573
uniprot id: Q8ZJV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

99287:STM3256
gene id: 99287:STM3256
uniprot id: Q8ZLV2
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM3796
gene id: 99287:STM3796
uniprot id: Q8ZL15
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

99287:STM2869
gene id: 99287:STM2869
uniprot id: P0CL45
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:28283062). Acts as a regulator of the InvC/SctN1 ATPase activity (By similarity). Required for invasion and secretion (PubMed:10816487).
messages: Cytoplasm
messages: Deletion of the gene disrupts proper SpaO/SctQ localization.
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569, PubMed:28283062). This subunit is part of the cytosolic complex (PubMed:28283062, PubMed:31288030). Interacts directly with InvC/SctN1 (T3SS-1 ATPase) and SpaO/SctQ (the major sorting platform component) (PubMed:15060043, PubMed:25994170, PubMed:28283062, PubMed:31288030). Forms homodimers (PubMed:31288030).

99287:STM4334
gene id: 99287:STM4334
uniprot id: P64036
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cells lacking EF-P display highly pleiotropic phenotypes similar to those lacking EmpA or EmpB. They exhibit reduced growth rates, and they display increased susceptibility to hypoosmotic conditions, antibiotics, and detergents and enhanced resistance to the compound S-nitrosoglutathione. The susceptibility phenotypes are largely explained by the enhanced membrane permeability of the efp mutant. Analysis of the membrane proteomes of wild-type and efp mutant strains reveals few changes, including the prominent overexpression of a single porin, KdgM (STM1131), in the efp mutant outer membrane.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
messages: Is beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC. Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety would extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. The hydroxylation of the C5 position on Lys-34 would allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA (Probable) (PubMed:20670890).

99287:STM3697
gene id: 99287:STM3697
uniprot id: Q8ZL58
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the efficient dehydration of both L-talarate (also called L-altrarate) and galactarate to 5-keto-4-deoxy-D-glucarate (5-KDG) (PubMed:17649980, PubMed:29248502). Also catalyzes the epimerization of L-talarate to galactarate; epimerization occurs in competition with dehydration. Is required for the utilization of L-talarate as a carbon source. Also functions in galactarate utilization. Is not active on other acid sugars (PubMed:17649980).
messages: Cells lacking this gene lose the ability to grow on L-talarate as carbon source, and are impaired in the ability to utilize galactarate as carbon source.
messages: Competitively inhibited by tartronate.
messages: Homooctamer; tetramer of dimers.
messages: The enzyme product is the enantiomer of the product obtained in the galactarate dehydratase reaction catalyzed by OB2843; the enzymes thus differ in their regiochemistry of dehydration.

99287:STM2497
gene id: 99287:STM2497
uniprot id: H9L4A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

99287:STM1744
gene id: 99287:STM1744
uniprot id: P08006
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
messages: Cell inner membrane
messages: Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.

99287:STM4474
gene id: 99287:STM4474
uniprot id: Q08022
names: Subcellular Location Annotation
messages: Cell inner membrane

99287:STM2676
gene id: 99287:STM2676
uniprot id: P0A2A9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.
messages: In addition to being a ribosomal protein, S16 also has a cation-dependent endonuclease activity.

99287:STM0444
gene id: 99287:STM0444
uniprot id: Q8ZRC2
names: Subcellular Location Annotation
messages: Membrane

99287:STM0247
gene id: 99287:STM0247
uniprot id: Q8ZRM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ).

99287:STM2306
gene id: 99287:STM2306
uniprot id: P58486
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

99287:STM3093
gene id: 99287:STM3093
uniprot id: Q8ZM53
names: Similarity
messages: Belongs to the EndA/NucM nuclease family.

99287:STM0564
gene id: 99287:STM0564
uniprot id: Q8ZR56
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

99287:STM2034
gene id: 99287:STM2034
uniprot id: Q05600
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. However, the true cosubstrate could be (R)-1-amino-2-propanol O-2-phosphate, leading to cobinamide phosphate.

99287:STM1342
gene id: 99287:STM1342
uniprot id: P63351
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).

99287:STM4049
gene id: 99287:STM4049
uniprot id: P40865
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Activates expression of the rhaSR operon in response to L-rhamnose.
messages: Binds DNA as a dimer.
messages: Cytoplasm

99287:STM3443
gene id: 99287:STM3443
uniprot id: O68926
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterioferritin family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center.
messages: Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

99287:STM2891
gene id: 99287:STM2891
uniprot id: P40699
names: Function
names: Similarity
messages: Belongs to the FliN/MopA/SpaO family.
messages: Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.

99287:STM1182
gene id: 99287:STM1182
uniprot id: P15931
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Exported via the flagellum-specific export pathway.
messages: Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
messages: In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
messages: In the N-terminal section; belongs to the FlgJ family.
messages: Periplasm

99287:STM3853
gene id: 99287:STM3853
uniprot id: Q7CPE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions.

99287:STM2948
gene id: 99287:STM2948
uniprot id: P38039
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.

99287:STM4108
gene id: 99287:STM4108
uniprot id: Q8ZKM9
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

99287:STM4243
gene id: 99287:STM4243
uniprot id: Q8ZKH4
names: Function
names: Similarity
messages: Belongs to the Dus family. DusA subfamily.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.

99287:STM3616
gene id: 99287:STM3616
uniprot id: Q8ZLB8
names: Function
names: Similarity
messages: Belongs to the AcsC/BcsC family.
messages: Required for maximal bacterial cellulose synthesis.

99287:STM4325
gene id: 99287:STM4325
uniprot id: Q8ZKC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

99287:STM0787
gene id: 99287:STM0787
uniprot id: Q8ZQR2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

99287:STM1455
gene id: 99287:STM1455
uniprot id: Q8ZPM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.
messages: The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.

99287:STM1326
gene id: 99287:STM1326
uniprot id: Q8ZPT5
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

99287:STM4470
gene id: 99287:STM4470
uniprot id: P0A1U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraB family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
messages: Interacts with the C-terminal region of Rne.

99287:STM2511
gene id: 99287:STM2511
uniprot id: Q8ZN59
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

99287:STM2467
gene id: 99287:STM2467
uniprot id: Q9ZFV4
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A quadruple eutP-eutQ-eutT-eutD deletion is not impaired for aerobic growth on ethanolamine (EA) supplemented with cobalamin (vitamin B12) (PubMed:10464203). Can grow on EA as sole carbon source when AdoB12 is supplied; double cobA-eutT mutants do not grow with CN-B12 as a nitrogen source (PubMed:15516577). A non-polar deletion mutant grows on EA from pH 5.5 to pH 8.0, but does not grow at pH 8.5, no change in acetaldehyde release on EA plus vitamin B12 (PubMed:16585748).
messages: Bacterial microcompartment
messages: Belongs to the Cob(I)alamin adenosyltransferase family. EutT subfamily.
messages: Binds 1 divalent metal cation ion per homodimer with both subunits providing Cys ligands; Fe(2+) gives most activity and is possibly the physiological cofactor, followed by Zn(2+) and Co(2+) (PubMed:24336938, PubMed:28045498). Activity stimulated by Mn(2+) (PubMed:16636051).
messages: Converts cyanocobalamin (CN-B12) to adenosylcobalamin (AdoCbl), the inducer of the eut operon (PubMed:15516577, PubMed:16636051, PubMed:24336938). Is not active on cobinamide nor other intermediates in the adenosylcobalamin synthetic pathway. Allows full induction of the eut operon (PubMed:15516577). Can use ADP, CTP and dATP in place of ATP, and cobinamide in place of cobalamin, none are as efficiently used as ATP and cobalamin (PubMed:16636051).
messages: Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Homodimer.
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).

99287:STM1612
gene id: 99287:STM1612
uniprot id: P58535
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

99287:STM3682
gene id: 99287:STM3682
uniprot id: Q8ZL70
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

99287:STM3971
gene id: 99287:STM3971
uniprot id: Q9L6M5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: During aerobic growth, mutant is impaired for ubiquinone biosynthesis and for growth in rich medium, but it does not present any defect under anaerobic conditions. Mutant is also impaired for Salmonella intracellular proliferation in macrophages.
messages: Required for ubiquinone (coenzyme Q) biosynthesis under aerobic conditions (PubMed:24142253). Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex (By similarity). May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates (By similarity). Required for intracellular proliferation in macrophages (PubMed:24142253).

99287:STM2311
gene id: 99287:STM2311
uniprot id: Q7CQ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

99287:STM1485
gene id: 99287:STM1485
uniprot id: Q8ZPK9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asr family.
messages: Periplasm
messages: Proteolytic processing gives rise to the active protein.
messages: Required for growth and/or survival at acidic conditions.

99287:STM0058
gene id: 99287:STM0058
uniprot id: Q8ZRY3
names: Function
messages: Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

99287:STM1383
gene id: 99287:STM1383
uniprot id: Q9Z4S6
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Cell inner membrane
messages: Mutants are defective in tetrathionate respiration.
messages: Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate. TtrA is the catalytic subunit. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
messages: Probably composed of three subunits: TtrA, TtrB and TtrC.
messages: Transcriptionally regulated by Fnr and by the TtrR/TtrS two-component regulatory system.

99287:STM4319
gene id: 99287:STM4319
uniprot id: P26976
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class A bacterial acid phosphatase family.
messages: Homodimer.
messages: Periplasm

99287:STM1945
gene id: 99287:STM1945
uniprot id: Q7CQB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Cell inner membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

99287:STM3744
gene id: 99287:STM3744
uniprot id: Q8ZL39
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

99287:STM3554
gene id: 99287:STM3554
uniprot id: Q8ZLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. sn-glycerol-3-phosphate importer (TC 3.A.1.1.3) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

99287:STM3183
gene id: 99287:STM3183
uniprot id: Q8ZLZ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-III family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.

99287:STM3134
gene id: 99287:STM3134
uniprot id: Q7CPT3
names: Subcellular Location Annotation
messages: Membrane

99287:STM3638
gene id: 99287:STM3638
uniprot id: P43662
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Involved in the export and assembly of LpfA fimbrial subunits across the outer membrane.

99287:STM0232
gene id: 99287:STM0232
uniprot id: P0A1C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

99287:STM1425
gene id: 99287:STM1425
uniprot id: Q8ZPP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
messages: Cell inner membrane
messages: Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.

99287:STM2278
gene id: 99287:STM2278
uniprot id: P37427
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A substrate-binding catalytic site, located on R1, is formed only in the presence of the second subunit R2.
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.
messages: Tetramer of two alpha (R1) and two beta (R2) subunits. The B1 protein is a dimer of alpha subunits. A radical transfer pathway occurs between Tyr-123 of R2 and R1 (By similarity).

99287:STM0060
gene id: 99287:STM0060
uniprot id: Q8ZRY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.
messages: Cytoplasm
messages: Oligomer with a subunit composition of (alpha,beta,gamma)6.
messages: Represents a citryl-ACP lyase.

99287:STM2543
gene id: 99287:STM2543
uniprot id: Q8ZN40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate.

99287:STM1965
gene id: 99287:STM1965
uniprot id: Q06400
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane

99287:STM3519
gene id: 99287:STM3519
uniprot id: Q8ZLH9
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

99287:STM1560
gene id: 99287:STM1560
uniprot id: Q8ZPF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

99287:STM3045
gene id: 99287:STM3045
uniprot id: P0A1N6
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

99287:STM0102
gene id: 99287:STM0102
uniprot id: P06189
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.
messages: Homohexamer.
messages: The N-terminus is probably modified.

99287:STM3966
gene id: 99287:STM3966
uniprot id: Q8ZKV2
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

99287:STM3763
gene id: 99287:STM3763
uniprot id: P22036
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Decreases Mg(2+) influx.
messages: Mediates magnesium influx to the cytosol.
messages: Part of the mgtC/mgtB operon. Induced by low extracellular levels of Mg(2+).

99287:STM2687
gene id: 99287:STM2687
uniprot id: Q7CPZ2
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

99287:STM1917
gene id: 99287:STM1917
uniprot id: P04042
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CheB family.
messages: Cells lacking this gene display a strong clockwise motor bias; in combination with a yhjH disruption cells switch to a counterclockwise bias.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity (PubMed:2991277, PubMed:9760239). The N-terminal domain is not essential for catalysis (PubMed:2991277).
messages: Cytoplasm
messages: Interacts with CheA.
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR (PubMed:2991277, PubMed:2677005, PubMed:9760239). Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid (By similarity).
messages: Phosphorylated by CheA (PubMed:3280143, PubMed:2677005, PubMed:9465023). Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity (PubMed:2677005, PubMed:9760239).
messages: Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.
messages: Two forms were isolated, the intact protein and a proteolytic fragment (147-349) that is 15-fold more active than its precursor.

99287:STM1620
gene id: 99287:STM1620
uniprot id: Q8ZPB5
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

99287:STM2468
gene id: 99287:STM2468
uniprot id: Q9ZFV5
names: Biotechnology
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A bidirectional acetate kinase that may drive flux through the ethanolamine (EA) degradation pathway under anoxic conditions found when this bacteria infects the host intestine. It may generate ATP that can be used by other enzymes (EutA and EutT) in the eut pathway. Can use GTP instead of ATP with reduced efficiency (PubMed:26448059). Might be required to correctly target EutE to bacterial microcompartments (BMC) (Probable). Required for the biogenesis of multiple mobile BMCs per cell. Might serve as an assembly hub for BMC shell proteins. Expression of eutK, eutL, eutM, eutN, eutS (eutSMNLK) in E.coli leads to formation of a single BMC; coexpression of eutQ with eutSMNLK permits E.coli to make cells with more than one mobile BMC, as is usual in vivo. EutS alone also forms BMCs, but in the presence of eutQ both BMCs and protein filaments are formed (PubMed:27063436).
messages: A quadruple eutP-eutQ-eutT-eutD deletion is not impaired for aerobic growth on ethanolamine (EA) supplemented with cobalamin (vitamin B12) (PubMed:10464203). A non-polar deletion mutant grows on EA from pH 5.5 to pH 8.0, but does not grow at pH 8.5, releases increased amounts of acetaldehyde on EA plus vitamin B12 (PubMed:16585748). Does not grow on EA and tetrathionate under anoxic conditions; complemented by acetate/propionate kinases AckA, PduW or TdcD (PubMed:26448059). Only makes a single immobile BMC localized near the cell pole (PubMed:27063436).
messages: Artificial BMCs can be made in E.coli by expressing eutK, eutL, eutM, eutN, eutS (eutSMNLK). Cargo proteins can be targeted to them. The addition of eutQ to the eutSMNLK construct results in biogenesis of multiple BMCs. This can lead to the development of tailored BMCs for specific metabolic reactions.
messages: Bacterial microcompartment
messages: Belongs to the EutQ cupin-like family.
messages: Does not need divalent cations.
messages: Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Homodimer (Probable). Interacts with the N-terminus of EutM; a probably cytoplasm-facing helix (EutM 'Val-49' to 'Gln-64') interacts with N-terminus of EutQ (PubMed:27063436).
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).

99287:STM4438
gene id: 99287:STM4438
uniprot id: Q7CP84
names: Function
names: Similarity
messages: Belongs to the peptidase U62 family.
messages: Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA).

99287:STM1742
gene id: 99287:STM1742
uniprot id: P08007
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system.

99287:STM3502
gene id: 99287:STM3502
uniprot id: P0AA19
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (By similarity). Plays a central role in both acid and osmotic stress responses. Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (By similarity).
messages: Monomer and multimer.
messages: Phosphorylated by EnvZ; this stimulates its DNA-binding ability. Asp-55 is the primary phosphate acceptor site.

99287:STM2877
gene id: 99287:STM2877
uniprot id: P0CL15
names: Similarity
messages: Belongs to the IagB/IpgF/P19 family.

99287:STM2305
gene id: 99287:STM2305
uniprot id: P37418
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
messages: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).

99287:STM2872
gene id: 99287:STM2872
uniprot id: P41785
names: Function
names: Similarity
messages: Required for invasion of epithelial cells.
messages: To S.flexneri MxiI.

99287:STM3539
gene id: 99287:STM3539
uniprot id: P0A1F8
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Cells lacking this gene have an obligate requirement for diaminopimelic acid (DAP) and undergo lysis in environments deprived of DAP.
messages: Homodimer.
messages: Vaccine strains for Salmonella typhimurium were successfully produced using strains with mutations in the asd gene.

99287:STM3486
gene id: 99287:STM3486
uniprot id: P77980
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

99287:STM3479
gene id: 99287:STM3479
uniprot id: P59696
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the IS200/IS605 insertion sequence (IS) element family.
messages: Belongs to the transposase 17 family.
messages: Homodimer.
messages: Transposase responsible for transposition of the IS200 insertion sequence (IS) element. Transposition occurs in 2 main steps, excision from the donor DNA 'top strand' into a single strand circle and its subsequent reinsertion into the DNA target. This increases the copy number of the IS.

99287:STM1848
gene id: 99287:STM1848
uniprot id: Q8ZNZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PqiA family.
messages: Component of a transport pathway that contributes to membrane integrity.
messages: Membrane

99287:STM1197
gene id: 99287:STM1197
uniprot id: Q8ZQ14
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

99287:STM0053
gene id: 99287:STM0053
uniprot id: Q8ZRY5
names: Subcellular Location Annotation
messages: Membrane

99287:STM3698
gene id: 99287:STM3698
uniprot id: Q8ZL57
names: Subcellular Location Annotation
messages: Membrane

99287:STM3374
gene id: 99287:STM3374
uniprot id: P0A9X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

99287:STM3488
gene id: 99287:STM3488
uniprot id: Q8ZLK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. PilQ subfamily.
messages: Cell outer membrane
messages: Membrane

99287:STM0367
gene id: 99287:STM0367
uniprot id: P74839
names: Function
messages: Involved in the transcriptional regulation of the propionate catabolism operon.

99287:STM3692
gene id: 99287:STM3692
uniprot id: Q8ZL63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell inner membrane
messages: Uptake of L-lactate across the membrane (By similarity). Can also transport D-lactate and glycolate (By similarity). Seems to be driven by a proton motive force (By similarity).

99287:STM2582
gene id: 99287:STM2582
uniprot id: P0A1W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell inner membrane

99287:STM4360
gene id: 99287:STM4360
uniprot id: P37724
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

99287:STM1817
gene id: 99287:STM1817
uniprot id: Q8ZP09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase D family.
messages: Cytoplasm
messages: Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.

99287:STM0413
gene id: 99287:STM0413
uniprot id: P0A261
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.
messages: Cell outer membrane
messages: Functions as substrate-specific channel for nucleosides and deoxynucleosides. Functions also in albicidin uptake and as receptor for colicin K.

99287:STM0211
gene id: 99287:STM0211
uniprot id: Q7CR64
names: Similarity
messages: Belongs to the UPF0325 family.

99287:STM3590
gene id: 99287:STM3590
uniprot id: P67686
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein B family.
messages: Cell inner membrane

99287:STM2368
gene id: 99287:STM2368
uniprot id: Q8ZNB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

99287:STM1914
gene id: 99287:STM1914
uniprot id: P40727
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell inner membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

99287:PSLT059
gene id: 99287:PSLT059
uniprot id: Q93GQ3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

99287:STM3458
gene id: 99287:STM3458
uniprot id: P65510
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.
messages: Cell inner membrane
messages: Interacts with KefB.
messages: Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.

99287:STM2226
gene id: 99287:STM2226
uniprot id: P67714
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

99287:STM1737
gene id: 99287:STM1737
uniprot id: P25945
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Homodimer. Forms a complex with the accessory proteins ExbB and ExbD (By similarity).
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

99287:STM2221
gene id: 99287:STM2221
uniprot id: Q8ZNJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

99287:STM0794
gene id: 99287:STM0794
uniprot id: P12678
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

99287:STM1242
gene id: 99287:STM1242
uniprot id: Q56030
names: Subcellular Location Annotation
messages: Cell membrane

99287:STM2193
gene id: 99287:STM2193
uniprot id: P64209
names: Activity Regulation
names: Similarity
names: Subunit
messages: Allosteric enzyme. Activity is modulated by K(+), divalent cations, UTP, and tetrahydrobiopterin. Tetrahydrobiopterin is an inhibitor of this enzyme (By similarity).
messages: Belongs to the GTP cyclohydrolase I family.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

99287:STM4486
gene id: 99287:STM4486
uniprot id: Q8ZK20
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

99287:STM0611
gene id: 99287:STM0611
uniprot id: Q8ZR20
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

99287:STM3106
gene id: 99287:STM3106
uniprot id: Q7CPT7
names: Similarity
messages: Belongs to the asparaginase 1 family.

99287:STM2349
gene id: 99287:STM2349
uniprot id: Q8ZNC9
names: Similarity
messages: Belongs to the GST superfamily.

99287:STM0534
gene id: 99287:STM0534
uniprot id: Q8ZR70
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

99287:STM0685
gene id: 99287:STM0685
uniprot id: Q8ZQX6
names: Subcellular Location Annotation
messages: Membrane

99287:STM0166
gene id: 99287:STM0166
uniprot id: Q8ZRS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cytoplasm
messages: Homodimer or homotetramer.

99287:STM3130
gene id: 99287:STM3130
uniprot id: Q8ZM27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GpW/Gp25 family. IraD subfamily.
messages: Cytoplasm
messages: Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
messages: Interacts with RssB.

99287:STM3677
gene id: 99287:STM3677
uniprot id: Q8ZL75
names: Similarity
messages: Belongs to the aldolase class II family. AraD/FucA subfamily.

99287:STM1975
gene id: 99287:STM1975
uniprot id: P26417
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.

99287:STM4001
gene id: 99287:STM4001
uniprot id: P64068
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

99287:STM1135
gene id: 99287:STM1135
uniprot id: Q8ZQ30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
messages: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
messages: Cytoplasm

99287:STM3414
gene id: 99287:STM3414
uniprot id: Q7CPL7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

99287:STM0479
gene id: 99287:STM0479
uniprot id: Q8ZRA4
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

99287:STM2277
gene id: 99287:STM2277
uniprot id: P37426
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide.
messages: S.typhimurium produces two separate class I enzymes. This one is the functional enzyme during growth.
messages: Tetramer of two alpha (R1) and two beta (R2) subunits. The B1 protein is a dimer of alpha subunits. A radical transfer pathway occurs between 'Tyr-122' of R2 and R1.
messages: Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to separate specificity and activation sites on the alpha subunit. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site (By similarity).

99287:STM3858
gene id: 99287:STM3858
uniprot id: Q8ZKX4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM4296
gene id: 99287:STM4296
uniprot id: Q8ZKE3
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

99287:STM3817
gene id: 99287:STM3817
uniprot id: Q8XGY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

99287:STM0591
gene id: 99287:STM0591
uniprot id: Q7CR00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

99287:STM1933
gene id: 99287:STM1933
uniprot id: Q8ZNU6
names: Similarity
messages: Belongs to the LacAB/RpiB family.

99287:STM2677
gene id: 99287:STM2677
uniprot id: Q7CPZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

99287:STM0092
gene id: 99287:STM0092
uniprot id: Q7CR87
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

99287:STM4086
gene id: 99287:STM4086
uniprot id: Q8ZKP3
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activity of this regulatory enzyme is affected by several metabolites. Allosterically and non-competitively inhibited by fructose 1,6-bisphosphate (FBP) and unphosphorylated phosphocarrier protein EIIA-Glc (III-Glc), an integral component of the bacterial phosphotransferase (PTS) system.
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium). Heterodimer with EIIA-Glc. Binds 1 zinc ion per glycerol kinase EIIA-Glc dimer. The zinc ion is important for dimerization.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

99287:STM1066
gene id: 99287:STM1066
uniprot id: Q8ZQ70
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates exclusively with 100S ribosomes.
messages: Belongs to the ribosome modulation factor family.
messages: Cytoplasm
messages: During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes). May form immature 90S particles, which are converted to mature 100S ribosomes by the hibernation promoting factor Hpf.
messages: Induced during stationary growth phase.

99287:STM4469
gene id: 99287:STM4469
uniprot id: Q08016
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Homotrimer.
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

99287:STM3356
gene id: 99287:STM3356
uniprot id: Q8ZLP9
names: Subcellular Location Annotation
messages: Membrane

99287:STM1627
gene id: 99287:STM1627
uniprot id: Q8ZPA8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

99287:STM0826
gene id: 99287:STM0826
uniprot id: Q8ZQN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 1618 of 23S rRNA.

99287:STM1498
gene id: 99287:STM1498
uniprot id: Q8ZPJ7
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

99287:STM0045
gene id: 99287:STM0045
uniprot id: Q7CR93
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

99287:STM2330
gene id: 99287:STM2330
uniprot id: Q8ZNE1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

99287:STM3631
gene id: 99287:STM3631
uniprot id: Q8ZLA8
names: Subcellular Location Annotation
messages: Membrane

99287:STM2259
gene id: 99287:STM2259
uniprot id: Q8ZNH6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

99287:STM1521
gene id: 99287:STM1521
uniprot id: P0A2L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane

99287:STM0095
gene id: 99287:STM0095
uniprot id: Q8ZRV9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs.

99287:STM3146
gene id: 99287:STM3146
uniprot id: Q8ZM17
names: Similarity
messages: Belongs to the peptidase A31 family.

99287:STM2840
gene id: 99287:STM2840
uniprot id: Q8ZMJ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase.
messages: Binds 1 FMN per monomer.
messages: Binds 3 Fe cations per monomer.
messages: Cytoplasm
messages: Homotetramer.
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

99287:STM2985
gene id: 99287:STM2985
uniprot id: Q7CPV7
names: Similarity
messages: Belongs to the SufE family.

99287:STM4418
gene id: 99287:STM4418
uniprot id: Q8ZK64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell inner membrane
messages: Membrane

99287:STM3730
gene id: 99287:STM3730
uniprot id: Q8ZL47
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM0680
gene id: 99287:STM0680
uniprot id: Q8ZQY0
names: Similarity
messages: Belongs to the asparagine synthetase family.

99287:STM4569
gene id: 99287:STM4569
uniprot id: P63923
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

99287:STM3229
gene id: 99287:STM3229
uniprot id: Q7CPR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

99287:STM3818
gene id: 99287:STM3818
uniprot id: Q8XF64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

99287:STM3747
gene id: 99287:STM3747
uniprot id: Q7CPH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

99287:STM2336
gene id: 99287:STM2336
uniprot id: Q8ZND7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0208 family.
messages: Cell inner membrane

99287:STM0061
gene id: 99287:STM0061
uniprot id: Q8ZRY1
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM0872
gene id: 99287:STM0872
uniprot id: P0A1P8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaredoxin family.
messages: Monomer.
messages: The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase (By similarity).

99287:STM3802
gene id: 99287:STM3802
uniprot id: Q8ZL08
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family. DsdA subfamily.
messages: Monomer.

99287:STM0110
gene id: 99287:STM0110
uniprot id: P04787
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

99287:STM3053
gene id: 99287:STM3053
uniprot id: Q8ZM76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

99287:STM3267
gene id: 99287:STM3267
uniprot id: Q7CPQ6
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipoprotein DolP family.
messages: Cell outer membrane
messages: Disruption of the gene results in a defective outer membrane barrier with elevated sensitivity to a range of compounds (PubMed:30201701). Mutant shows attenuated virulence in an oral infection model and during the early stages of systemic infection (PubMed:30201701). Loss of the gene does not have a global effect on outer membrane proteins, lipopolysaccharide or lipoprotein production, and does not impact adhesion, invasion or intracellular survival (PubMed:30201701).
messages: Plays an important role in maintaining outer membrane integrity (PubMed:30201701). Contributes to virulence (PubMed:30201701).
messages: Transcriptionally regulated by sigma-E factor.

99287:STM1061
gene id: 99287:STM1061
uniprot id: Q8ZQ73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

99287:STM4392
gene id: 99287:STM4392
uniprot id: Q8ZK82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PriB family.
messages: Binds single-stranded DNA at the primosome assembly site (PAS). During primosome assembly it facilitates the complex formation between PriA and DnaT.
messages: Component of the preprimosomal complex composed of one monomer of PriC and DnaT, two monomers of PriA, two dimers of PriB and one hexamer of DnaB. Upon transient interaction with DnaG it forms the primosome.

99287:STM2427
gene id: 99287:STM2427
uniprot id: Q8ZN89
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

99287:STM2274
gene id: 99287:STM2274
uniprot id: Q8ZNH0
names: Subcellular Location Annotation
messages: Membrane

99287:STM0012
gene id: 99287:STM0012
uniprot id: Q56073
names: Function
names: Induction
names: PTM
names: Similarity
messages: Acts as a chaperone.
messages: Autophosphorylated; GrpE inhibits the autophosphorylation.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock (By similarity).

99287:STM1330
gene id: 99287:STM1330
uniprot id: Q8ZPT1
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

99287:STM1210
gene id: 99287:STM1210
uniprot id: P67366
names: Similarity
messages: Belongs to the UPF0227 family.

99287:STM0415
gene id: 99287:STM0415
uniprot id: P0A2M1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

99287:STM1807
gene id: 99287:STM1807
uniprot id: P63993
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family.
messages: Cell inner membrane
messages: Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein (By similarity).

99287:STM2999
gene id: 99287:STM2999
uniprot id: Q8ZMB1
names: Subcellular Location Annotation
messages: Membrane

99287:STM1801
gene id: 99287:STM1801
uniprot id: P65524
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
messages: Cell inner membrane
messages: K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.

99287:PSLT034
gene id: 99287:PSLT034
uniprot id: Q93GR3
names: Similarity
messages: Belongs to the intimin/invasin family.

99287:STM2260
gene id: 99287:STM2260
uniprot id: Q7CQ60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

99287:STM2151
gene id: 99287:STM2151
uniprot id: Q8ZNN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

99287:STM2256
gene id: 99287:STM2256
uniprot id: Q7CQ61
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapB family.
messages: Binds 2 heme C groups per subunit.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Electron transfer subunit of the periplasmic nitrate reductase complex NapAB.
messages: Periplasm

99287:STM3126
gene id: 99287:STM3126
uniprot id: Q8ZM30
names: Subcellular Location Annotation
messages: Membrane

99287:STM1716
gene id: 99287:STM1716
uniprot id: Q7CQG3
names: Similarity
messages: Belongs to the peptidase S49 family.

99287:STM2406
gene id: 99287:STM2406
uniprot id: Q8ZNA1
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

99287:STM4591
gene id: 99287:STM4591
uniprot id: Q8ZJU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM1923
gene id: 99287:STM1923
uniprot id: P55891
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MotA family.
messages: Cell inner membrane
messages: Each stator complex is composed of 4 MotA and 2 MotB subunits. 2 A subunits and 1 B subunit are thought to form a single ion channel, so that each stator complex contains two channels (By similarity).
messages: MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel (By similarity).

99287:STM2147
gene id: 99287:STM2147
uniprot id: P55883
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

99287:STM1319
gene id: 99287:STM1319
uniprot id: Q8ZPU0
names: Function
names: Similarity
messages: Activates the cell division inhibited by chromosomal DNA over-replication.
messages: Belongs to the CedA family.

99287:STM1998
gene id: 99287:STM1998
uniprot id: P22493
names: Function
names: Similarity
messages: Belongs to the peptidase S24 family.
messages: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template.

99287:STM0547
gene id: 99287:STM0547
uniprot id: P37925
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium
messages: Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). A mannose-binding adhesin (By similarity).

99287:STM2020
gene id: 99287:STM2020
uniprot id: Q05596
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Cobalt importer (TC 3.A.1.18.1) family.
messages: Cell inner membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry. Expression of just CbiMN in E.coli confers some cobalt uptake.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. Presumably responsible for energy coupling to the transport system.

99287:STM2068
gene id: 99287:STM2068
uniprot id: Q7CQB1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM3670
gene id: 99287:STM3670
uniprot id: Q8ZL81
names: Similarity
messages: Belongs to the YiaX1 family.

99287:STM3935
gene id: 99287:STM3935
uniprot id: Q8ZKV4
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Involved in a late step of protoheme IX synthesis.
messages: Membrane

99287:STM0200
gene id: 99287:STM0200
uniprot id: Q8ZRP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM3746
gene id: 99287:STM3746
uniprot id: Q8ZL37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

99287:STM3967
gene id: 99287:STM3967
uniprot id: Q9L6M9
names: Similarity
messages: Belongs to the dienelactone hydrolase family.

99287:STM1900
gene id: 99287:STM1900
uniprot id: Q8ZNV3
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

99287:STM1749
gene id: 99287:STM1749
uniprot id: Q8ZP45
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

99287:STM0607
gene id: 99287:STM0607
uniprot id: Q8ZR22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

99287:STM0722
gene id: 99287:STM0722
uniprot id: Q8ZQV2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

99287:STM2149
gene id: 99287:STM2149
uniprot id: Q8ZNN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial protein family.
messages: Fimbrium

99287:STM1792
gene id: 99287:STM1792
uniprot id: Q8ZP24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

99287:STM1569
gene id: 99287:STM1569
uniprot id: Q8ZPE6
names: Cofactor
names: Function
messages: Binds 4 [4Fe-4S] clusters per subunit.
messages: The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.

99287:STM4078
gene id: 99287:STM4078
uniprot id: Q8ZKQ0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family.
messages: Cytoplasm
messages: Homodecamer.
messages: In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor.
messages: Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA.

99287:STM3814
gene id: 99287:STM3814
uniprot id: Q8XGT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

99287:STM1793
gene id: 99287:STM1793
uniprot id: Q8ZP23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

99287:STM2568
gene id: 99287:STM2568
uniprot id: Q7CQ08
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

99287:STM0803
gene id: 99287:STM0803
uniprot id: Q7CQW6
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

99287:STM0549
gene id: 99287:STM0549
uniprot id: P26319
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM3189
gene id: 99287:STM3189
uniprot id: Q8ZLZ3
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

99287:STM3920
gene id: 99287:STM3920
uniprot id: Q9L6R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
messages: Catalyzes the reversible epimerization at C-2 of UDP-N-acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.
messages: Cytoplasm
messages: Homodimer.

99287:STM3671
gene id: 99287:STM3671
uniprot id: Q7CPI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

99287:STM1846
gene id: 99287:STM1846
uniprot id: P60317
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ProQ family.
messages: Cytoplasm
messages: RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism.

99287:STM3979
gene id: 99287:STM3979
uniprot id: Q9L6L9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein oxidoreductase family.
messages: Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides.
messages: Monomer.

99287:STM3847
gene id: 99287:STM3847
uniprot id: Q8ZKY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
messages: Cell inner membrane

99287:STM1722
gene id: 99287:STM1722
uniprot id: P03054
names: Function
messages: This protein is involved in control of the biosynthesis of tryptophan.

99287:STM1636
gene id: 99287:STM1636
uniprot id: Q8ZPA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

99287:STM0130
gene id: 99287:STM0130
uniprot id: Q8ZRU1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm
messages: Monomer.

99287:STM2799
gene id: 99287:STM2799
uniprot id: P0A1S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A DNA-binding protein that acts in a fashion similar to H-NS, repressing gene transcription. A subset of H-NS/StpA-regulated genes require auxillary proteins for repression; these auxillary proteins (Hha and other similar proteins) may also modulate oligomerization of the H-NS/StpA complex (By similarity).
messages: Belongs to the histone-like protein H-NS family.
messages: Forms homodimers, can interact with H-NS.
messages: nucleoid

99287:STM2203
gene id: 99287:STM2203
uniprot id: Q8ZNK6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

99287:STM0183
gene id: 99287:STM0183
uniprot id: Q8ZRQ9
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

99287:STM3851
gene id: 99287:STM3851
uniprot id: Q8ZKX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

99287:STM0443
gene id: 99287:STM0443
uniprot id: Q7CR26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

99287:STM2896
gene id: 99287:STM2896
uniprot id: P0A1I3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell inner membrane
messages: Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein.

99287:STM1148
gene id: 99287:STM1148
uniprot id: Q8ZQ28
names: Function
names: Similarity
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily.
messages: Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE).

99287:STM0464
gene id: 99287:STM0464
uniprot id: Q8ZRB2
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

99287:STM2085
gene id: 99287:STM2085
uniprot id: P26403
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

99287:STM3099
gene id: 99287:STM3099
uniprot id: Q8ZM48
names: Similarity
messages: Belongs to the GSP E family.

99287:STM0597
gene id: 99287:STM0597
uniprot id: Q8ZR31
names: Cofactor
messages: Binds 1 phosphopantetheine covalently.

99287:STM0127
gene id: 99287:STM0127
uniprot id: Q7CR82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

99287:STM3216
gene id: 99287:STM3216
uniprot id: Q8ZLX9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

99287:STM1202
gene id: 99287:STM1202
uniprot id: Q8ZQ11
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

99287:STM3457
gene id: 99287:STM3457
uniprot id: Q8ZLL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily.
messages: Cell inner membrane
messages: Interacts with the regulatory subunit KefG.
messages: Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.

99287:STM3462
gene id: 99287:STM3462
uniprot id: Q8ZLL1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

99287:STM1316
gene id: 99287:STM1316
uniprot id: Q8ZPU2
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

99287:STM2066
gene id: 99287:STM2066
uniprot id: Q8ZNR3
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SopA E3 ligase family.
messages: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway (PubMed:28084320). For instance, prevents host innate immune response by ubiquitinating and thus sending to degradation host E3 ubiquitin ligases TRIM56 and TRIM65 (PubMed:28084320). Required for inducing polymorphonuclear leukocytes migration across the intestinal epithelium. Preferentially uses host UBE2D1 (UBCH5A), UBE2D2 (UBCH5B) and UBE2L3 (UBCH7) as E2 ubiquitin-conjugating enzymes.
messages: Host cell
messages: Interacts with SpaK/InvB.
messages: Requires SpaK/InvB as a chaperone for its stability and for secretion.
messages: Secreted
messages: The N-terminal 45 amino acids are necessary and sufficient for secretion and translocation into host cells. This N-terminal region binds the SpaK/InvB chaperone. Contains a C-terminal HECT-like domain.
messages: Ubiquitinated in the presence of host E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme and ubiquitin.

99287:STM0785
gene id: 99287:STM0785
uniprot id: Q8ZQR4
names: Function
names: Similarity
messages: Belongs to the cycloisomerase 2 family.
messages: Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

99287:STM3977
gene id: 99287:STM3977
uniprot id: Q9L6M1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RfaH family.
messages: Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains.
messages: Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).

99287:STM3726
gene id: 99287:STM3726
uniprot id: O54326
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
messages: Monomer.

99287:STM4249
gene id: 99287:STM4249
uniprot id: P58683
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class B bacterial acid phosphatase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cells lacking this gene show a severely decreased growth rate on 5'-UMP as pyrimidine source.
messages: Dephosphorylates several organic phosphate monoesters such as 3'-UMP, 5'-UMP and pNPP (PubMed:6256351). Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds such as the 2'-, 3-, or 5'-hydroxyls of nucleosides and nucleotides (PubMed:3049613). Also displays significant phosphomutase activity since it is able to catalyze the transfer of the phosphate group of 3'-AMP from the 3'-position both to the 2'- and 5'-positions. One of the physiological functions of the phosphohydrolytic activity of the enzyme is believed to be the scavenging of organic phosphate esters that otherwise cannot pass the cytoplasmic membrane (PubMed:6256351).
messages: Homotetramer.
messages: Nucleosides, and particularly 2'-deoxyribonucleosides, are potent inhibitors of the phosphatase activity. The phosphatase activity is also inhibited by inorganic phosphate and EDTA in vitro.
messages: Periplasm

99287:STM0054
gene id: 99287:STM0054
uniprot id: Q8ZRY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcdB/MmdB/OadB family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.

99287:STM2397
gene id: 99287:STM2397
uniprot id: P37433
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation.

99287:STM3838
gene id: 99287:STM3838
uniprot id: P35891
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. DnaA can inhibit its own gene expression as well as that of other genes (By similarity).
messages: Some 20 DnaA protein molecules bind their sites in oriC.

99287:STM0310
gene id: 99287:STM0310
uniprot id: P63223
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

99287:STM3076
gene id: 99287:STM3076
uniprot id: Q8ZM63
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

99287:STM1824
gene id: 99287:STM1824
uniprot id: P12680
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Monomer. Heterodimer consisting of two non-identical subunits: a glutamine amidotransferase subunit (PabA) and a aminodeoxychorismate synthase subunit (PabB) (By similarity).
messages: Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC (By similarity).

99287:STM2577
gene id: 99287:STM2577
uniprot id: P63466
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

99287:STM0877
gene id: 99287:STM0877
uniprot id: Q8ZQK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

99287:STM3436
gene id: 99287:STM3436
uniprot id: P66491
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

99287:STM2385
gene id: 99287:STM2385
uniprot id: P0A293
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Specifically methylates large ribosomal subunit protein uL3 on 'Gln-150'.

99287:STM1125
gene id: 99287:STM1125
uniprot id: P10502
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell inner membrane
messages: Expression may be repressed by PutA in the absence of proline.

99287:STM1797
gene id: 99287:STM1797
uniprot id: Q7CQE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

99287:STM3882
gene id: 99287:STM3882
uniprot id: Q8ZKV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system.
messages: The complex is composed of an ATP-binding protein (RbsA), two transmembrane proteins (RbsC) and a solute-binding protein (RbsB).

99287:STM4003
gene id: 99287:STM4003
uniprot id: P0A2N8
names: Function
names: Similarity
names: Subunit
messages: A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.
messages: Belongs to the YihI family.
messages: Interacts with Der.

99287:STM1928
gene id: 99287:STM1928
uniprot id: P0CL06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase 20 family.
messages: Homotetramer.
messages: Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor.

99287:STM1837
gene id: 99287:STM1837
uniprot id: P0A9Y9
names: Subcellular Location Annotation
messages: Cytoplasm

99287:STM0659
gene id: 99287:STM0659
uniprot id: Q8ZQY6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

99287:STM3879
gene id: 99287:STM3879
uniprot id: Q8ZKW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RavA family.
messages: Cytoplasm
messages: Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone.

99287:STM4100
gene id: 99287:STM4100
uniprot id: Q8ZKN5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

99287:STM3982
gene id: 99287:STM3982
uniprot id: P0A2H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids (By similarity).
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).

99287:STM4480
gene id: 99287:STM4480
uniprot id: Q8ZK26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

99287:STM2927
gene id: 99287:STM2927
uniprot id: P66881
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.

99287:STM3649
gene id: 99287:STM3649
uniprot id: P0A9Y2
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Binds to and stimulates the transcription of the CCAAT-containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3' (By similarity).
messages: Cytoplasm
messages: In response to low temperature.

99287:STM3790
gene id: 99287:STM3790
uniprot id: P27667
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region.
messages: Phosphorylated and dephosphorylated by UhpB.

99287:STM0991
gene id: 99287:STM0991
uniprot id: Q7CQT6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.
messages: Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs.

99287:STM2074
gene id: 99287:STM2074
uniprot id: P10368
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.

99287:STM2386
gene id: 99287:STM2386
uniprot id: P67246
names: Similarity
messages: Belongs to the UPF0115 family.

99287:STM1349
gene id: 99287:STM1349
uniprot id: Q8ZPS3
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

99287:STM0450
gene id: 99287:STM0450
uniprot id: Q8ZRB9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

99287:STM4248
gene id: 99287:STM4248
uniprot id: P74861
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm
messages: Homodimer.

99287:STM1915
gene id: 99287:STM1915
uniprot id: P07800
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CheZ family.
messages: Cells lacking this gene display a strong clockwise motor bias; in combination with a yhjH disruption and overexpression of ycgR, cells switch from clockwise to a counterclockwise bias.
messages: Cytoplasm
messages: Homodimer. Interacts (via C-terminus) with phosphorylated CheY (CheY-P).
messages: Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P). Acts on free CheY-P.

99287:STM4362
gene id: 99287:STM4362
uniprot id: Q8ZKA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

99287:STM4338
gene id: 99287:STM4338
uniprot id: Q7CP98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Gdx/SugE subfamily.
messages: Cell inner membrane
messages: Guanidinium ion exporter. Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons.

99287:STM2802
gene id: 99287:STM2802
uniprot id: Q8ZML4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

99287:STM1119
gene id: 99287:STM1119
uniprot id: Q8ZQ40
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.

99287:STM3061
gene id: 99287:STM3061
uniprot id: Q8ZM70
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

99287:STM4495
gene id: 99287:STM4495
uniprot id: Q8ZK12
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

99287:STM0863
gene id: 99287:STM0863
uniprot id: Q8ZQL1
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

99287:STM2059
gene id: 99287:STM2059
uniprot id: P67605
names: Similarity
messages: Belongs to the UPF0265 family.

99287:STM2455
gene id: 99287:STM2455
uniprot id: Q9ZFU8
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A component of the bacterial microcompartment (BMC) shell dedicated to ethanolamine degradation. Expression of eutK, eutL, eutM, eutN, eutS (eutSMNLK) in E.coli leads to formation of a single BMC (PubMed:22428024, PubMed:27063436). Coexpression of eutQ with eutSMNLK permits E.coli to make cells with more than one mobile BMC, as is usual in vivo (PubMed:27063436).
messages: Artificial BMCs can be made in E.coli by expressing eutK, eutL, eutM, eutN, eutS (eutSMNLK) or eutS alone. Cargo proteins can be targeted to them and beta-galactosidase (lacZ) was active within the BMC, showing the BMC allows passage of substrate into the interior. This can lead to the development of tailored BMCs for specific metabolic reactions (PubMed:22428024, PubMed:27063436). The addition of eutQ to the eutSMNLK construct results in biogenesis of multiple BMCs (PubMed:27063436).
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.
messages: Expression of the eut operon allows this bacteria to use ethanolamine as a carbon, nitrogen and energy source. It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078). EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
messages: Monomeric in solution.
messages: Not required for aerobic growth on ethanolamine (EA) supplemented with cobalamin (vitamin B12) (PubMed:10464203). A double eutL-eutK strain grows as well as wild-type on EA and cyanocobalamin, but a quadruple eutL-eutK eutM-eutN strain does not grow (PubMed:16291677). A non-polar deletion mutant grows on EA at pH 5.5 to pH 7.0 but not at pH 8.0 or pH 8.5, releases increased amounts of acetaldehyde on EA plus vitamin B12. Preventing acetaldehyde vapor loss allow growth up to pH 8.5 (PubMed:16585748).
messages: Part of the 17-gene eut operon transcribed from a single promoter, induced by ethanolamine and adenosylcobalamin (AdoCbl, vitamin B12).
messages: The ethanolamine (EA) catabolic bacterial microcompartment (BMC) probably concentrates low levels of ethanolamine catabolic enzymes, concentrates volatile reaction intermediates, keeps the level of toxic acetaldehyde low, generates enough acetyl-CoA to support cell growth, and maintains a pool of free coenzyme A (CoA) and NAD (Probable) (PubMed:16585748). Deletion of BMC genes (eutK, eutL, eutM) restores growth of eutD deletions, suggesting there are dedicated pools of coenzyme A (CoA) and NAD in the BMC (PubMed:23585538).
messages: The need for a bacterial microcompartment in EA metabolism can be bypassed by increasing the levels of EAL and an acetaldehyde dehydrogenase (not necessarily EutE).