990316:MCON RS13980
gene id: 990316:MCON_RS13980
uniprot id: F4BV02
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

990316:MCON RS10345
gene id: 990316:MCON_RS10345
uniprot id: F4BYL7
names: Similarity
messages: Belongs to the UPF0175 family.

990316:MCON RS10855
gene id: 990316:MCON_RS10855
uniprot id: F4BZB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

990316:MCON RS05680
gene id: 990316:MCON_RS05680
uniprot id: F4C0K3
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

990316:MCON RS11135
gene id: 990316:MCON_RS11135
uniprot id: F4BZG6
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

990316:MCON RS09105
gene id: 990316:MCON_RS09105
uniprot id: F4BXA0
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

990316:MCON RS05320
gene id: 990316:MCON_RS05320
uniprot id: F4C056
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

990316:MCON RS12375
gene id: 990316:MCON_RS12375
uniprot id: F4C0T4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

990316:MCON RS06435
gene id: 990316:MCON_RS06435
uniprot id: F4BTF2
names: Similarity
messages: Belongs to the Ahb/Nir family.

990316:MCON RS03425
gene id: 990316:MCON_RS03425
uniprot id: F4BY85
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

990316:MCON RS02690
gene id: 990316:MCON_RS02690
uniprot id: F4BXD6
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS11390
gene id: 990316:MCON_RS11390
uniprot id: F4BZU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

990316:MCON RS03975
gene id: 990316:MCON_RS03975
uniprot id: F4BYR4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

990316:MCON RS14215
gene id: 990316:MCON_RS14215
uniprot id: F4BVK4
names: Similarity
messages: Belongs to the glutamate synthase family.

990316:MCON RS08725
gene id: 990316:MCON_RS08725
uniprot id: F4BWV2
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

990316:MCON RS02295
gene id: 990316:MCON_RS02295
uniprot id: F4BWY1
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS00585
gene id: 990316:MCON_RS00585
uniprot id: F4BUH1
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

990316:MCON RS07320
gene id: 990316:MCON_RS07320
uniprot id: F4BUT1
names: Caution
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS06135
gene id: 990316:MCON_RS06135
uniprot id: F4BSY9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

990316:MCON RS08375
gene id: 990316:MCON_RS08375
uniprot id: F4BWN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

990316:MCON RS10685
gene id: 990316:MCON_RS10685
uniprot id: F4BZ05
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

990316:MCON RS06510
gene id: 990316:MCON_RS06510
uniprot id: F4BTG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

990316:MCON RS12225
gene id: 990316:MCON_RS12225
uniprot id: F4C0Q7
names: Similarity
messages: Belongs to the UPF0107 family.

990316:MCON RS11420
gene id: 990316:MCON_RS11420
uniprot id: F4BZU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

990316:MCON RS09670
gene id: 990316:MCON_RS09670
uniprot id: F4BY09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

990316:MCON RS14770
gene id: 990316:MCON_RS14770
uniprot id: F4BWC8
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

990316:MCON RS04635
gene id: 990316:MCON_RS04635
uniprot id: F4BZJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

990316:MCON RS04595
gene id: 990316:MCON_RS04595
uniprot id: F4BZA5
names: Similarity
messages: Belongs to the ZPR1 family.

990316:MCON RS13175
gene id: 990316:MCON_RS13175
uniprot id: F4BTN2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

990316:MCON RS14590
gene id: 990316:MCON_RS14590
uniprot id: F4BW89
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS10995
gene id: 990316:MCON_RS10995
uniprot id: F4BZD8
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS07795
gene id: 990316:MCON_RS07795
uniprot id: F4BVH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

990316:MCON RS11965
gene id: 990316:MCON_RS11965
uniprot id: F4C0C9
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS03285
gene id: 990316:MCON_RS03285
uniprot id: F4BXY4
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

990316:MCON RS08065
gene id: 990316:MCON_RS08065
uniprot id: F4BW33
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

990316:MCON RS05700
gene id: 990316:MCON_RS05700
uniprot id: F4C0K7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

990316:MCON RS10600
gene id: 990316:MCON_RS10600
uniprot id: F4BYZ1
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS13340
gene id: 990316:MCON_RS13340
uniprot id: F4BTR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

990316:MCON RS13845
gene id: 990316:MCON_RS13845
uniprot id: F4BUX7
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

990316:MCON RS08470
gene id: 990316:MCON_RS08470
uniprot id: F4BWQ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

990316:MCON RS13700
gene id: 990316:MCON_RS13700
uniprot id: F4BUE0
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS12260
gene id: 990316:MCON_RS12260
uniprot id: F4C0R4
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

990316:MCON RS11690
gene id: 990316:MCON_RS11690
uniprot id: F4C077
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

990316:MCON RS06545
gene id: 990316:MCON_RS06545
uniprot id: F4BTH3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS10840
gene id: 990316:MCON_RS10840
uniprot id: F4BZ33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

990316:MCON RS02220
gene id: 990316:MCON_RS02220
uniprot id: F4BWW6
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS03920
gene id: 990316:MCON_RS03920
uniprot id: F4BYQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

990316:MCON RS11020
gene id: 990316:MCON_RS11020
uniprot id: F4BZE3
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

990316:MCON RS00730
gene id: 990316:MCON_RS00730
uniprot id: F4BUK0
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

990316:MCON RS06005
gene id: 990316:MCON_RS06005
uniprot id: F4BSW4
names: Caution
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS04435
gene id: 990316:MCON_RS04435
uniprot id: F4BZ75
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS11130
gene id: 990316:MCON_RS11130
uniprot id: F4BZG5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

990316:MCON RS09790
gene id: 990316:MCON_RS09790
uniprot id: F4BY32
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

990316:MCON RS08970
gene id: 990316:MCON_RS08970
uniprot id: F4BX76
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

990316:MCON RS08945
gene id: 990316:MCON_RS08945
uniprot id: F4BX72
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

990316:MCON RS05060
gene id: 990316:MCON_RS05060
uniprot id: F4C003
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS13360
gene id: 990316:MCON_RS13360
uniprot id: F4BTR7
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

990316:MCON RS13970
gene id: 990316:MCON_RS13970
uniprot id: F4BV01
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

990316:MCON RS08355
gene id: 990316:MCON_RS08355
uniprot id: F4BWN5
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

990316:MCON RS01075
gene id: 990316:MCON_RS01075
uniprot id: F4BV79
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

990316:MCON RS06240
gene id: 990316:MCON_RS06240
uniprot id: F4BT09
names: Similarity
messages: Belongs to the ABC transporter superfamily.

990316:MCON RS06165
gene id: 990316:MCON_RS06165
uniprot id: F4BSZ4
names: Cofactor
messages: Binds 1 zinc ion per subunit.

990316:MCON RS14265
gene id: 990316:MCON_RS14265
uniprot id: F4BVL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

990316:MCON RS02440
gene id: 990316:MCON_RS02440
uniprot id: F4BX10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

990316:MCON RS02880
gene id: 990316:MCON_RS02880
uniprot id: F4BXH3
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

990316:MCON RS01220
gene id: 990316:MCON_RS01220
uniprot id: F4BVA5
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

990316:MCON RS07075
gene id: 990316:MCON_RS07075
uniprot id: F4BU75
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

990316:MCON RS02290
gene id: 990316:MCON_RS02290
uniprot id: F4BWY0
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS05225
gene id: 990316:MCON_RS05225
uniprot id: F4C038
names: Similarity
messages: Belongs to the Ahb/Nir family.

990316:MCON RS08230
gene id: 990316:MCON_RS08230
uniprot id: F4BW64
names: Similarity
messages: Belongs to the peptidase M24B family.

990316:MCON RS08245
gene id: 990316:MCON_RS08245
uniprot id: F4BW67
names: Similarity
messages: Belongs to the malic enzymes family.

990316:MCON RS11195
gene id: 990316:MCON_RS11195
uniprot id: F4BZH8
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

990316:MCON RS09320
gene id: 990316:MCON_RS09320
uniprot id: F4BXL8
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

990316:MCON RS01580
gene id: 990316:MCON_RS01580
uniprot id: F4BVX6
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

990316:MCON RS06450
gene id: 990316:MCON_RS06450
uniprot id: F4BTF5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

990316:MCON RS13450
gene id: 990316:MCON_RS13450
uniprot id: F4BU92
names: Similarity
messages: Belongs to the MCM family.

990316:MCON RS06380
gene id: 990316:MCON_RS06380
uniprot id: F4BTE1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS11105
gene id: 990316:MCON_RS11105
uniprot id: F4BZG0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

990316:MCON RS08195
gene id: 990316:MCON_RS08195
uniprot id: F4BW57
names: Similarity
messages: Belongs to the thymidylate kinase family.

990316:MCON RS10850
gene id: 990316:MCON_RS10850
uniprot id: F4BZB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

990316:MCON RS01610
gene id: 990316:MCON_RS01610
uniprot id: F4BVY3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS01405
gene id: 990316:MCON_RS01405
uniprot id: F4BVU7
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

990316:MCON RS06490
gene id: 990316:MCON_RS06490
uniprot id: F4BTG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

990316:MCON RS10545
gene id: 990316:MCON_RS10545
uniprot id: F4BYY0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

990316:MCON RS03090
gene id: 990316:MCON_RS03090
uniprot id: F4BXU4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

990316:MCON RS08125
gene id: 990316:MCON_RS08125
uniprot id: F4BW44
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS08615
gene id: 990316:MCON_RS08615
uniprot id: F4BWT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

990316:MCON RS07070
gene id: 990316:MCON_RS07070
uniprot id: F4BU74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

990316:MCON RS05215
gene id: 990316:MCON_RS05215
uniprot id: F4C036
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

990316:MCON RS06270
gene id: 990316:MCON_RS06270
uniprot id: F4BTC0
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

990316:MCON RS03290
gene id: 990316:MCON_RS03290
uniprot id: F4BXY5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

990316:MCON RS00710
gene id: 990316:MCON_RS00710
uniprot id: F4BUJ6
names: Similarity
messages: Belongs to the threonine synthase family.

990316:MCON RS02060
gene id: 990316:MCON_RS02060
uniprot id: F4BWK9
names: Similarity
messages: Belongs to the band 7/mec-2 family.

990316:MCON RS14530
gene id: 990316:MCON_RS14530
uniprot id: F4BVS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

990316:MCON RS09555
gene id: 990316:MCON_RS09555
uniprot id: F4BXR0
names: Similarity
messages: Belongs to the carbamate kinase family.

990316:MCON RS02685
gene id: 990316:MCON_RS02685
uniprot id: F4BXD5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS07080
gene id: 990316:MCON_RS07080
uniprot id: F4BU76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

990316:MCON RS04575
gene id: 990316:MCON_RS04575
uniprot id: F4BZA1
names: Similarity
messages: Belongs to the UPF0179 family.

990316:MCON RS02905
gene id: 990316:MCON_RS02905
uniprot id: F4BXH8
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

990316:MCON RS10710
gene id: 990316:MCON_RS10710
uniprot id: F4BZ09
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS11955
gene id: 990316:MCON_RS11955
uniprot id: F4C0C7
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS01535
gene id: 990316:MCON_RS01535
uniprot id: F4BVW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

990316:MCON RS06495
gene id: 990316:MCON_RS06495
uniprot id: F4BTG4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

990316:MCON RS06205
gene id: 990316:MCON_RS06205
uniprot id: F4BT02
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

990316:MCON RS07760
gene id: 990316:MCON_RS07760
uniprot id: F4BVG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

990316:MCON RS04650
gene id: 990316:MCON_RS04650
uniprot id: F4BZJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

990316:MCON RS12460
gene id: 990316:MCON_RS12460
uniprot id: F4C0U7
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS00070
gene id: 990316:MCON_RS00070
uniprot id: F4BTA2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

990316:MCON RS14410
gene id: 990316:MCON_RS14410
uniprot id: F4BVQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

990316:MCON RS00645
gene id: 990316:MCON_RS00645
uniprot id: F4BUI3
names: Similarity
messages: Belongs to the AAA ATPase family.

990316:MCON RS13015
gene id: 990316:MCON_RS13015
uniprot id: F4BTK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

990316:MCON RS07470
gene id: 990316:MCON_RS07470
uniprot id: F4BUW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

990316:MCON RS01830
gene id: 990316:MCON_RS01830
uniprot id: F4BWG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

990316:MCON RS11665
gene id: 990316:MCON_RS11665
uniprot id: F4BZZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

990316:MCON RS08915
gene id: 990316:MCON_RS08915
uniprot id: F4BX67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane

990316:MCON RS08685
gene id: 990316:MCON_RS08685
uniprot id: F4BWU4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

990316:MCON RS10170
gene id: 990316:MCON_RS10170
uniprot id: F4BYI2
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

990316:MCON RS02680
gene id: 990316:MCON_RS02680
uniprot id: F4BXD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

990316:MCON RS07280
gene id: 990316:MCON_RS07280
uniprot id: F4BUS3
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

990316:MCON RS11400
gene id: 990316:MCON_RS11400
uniprot id: F4BZU3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

990316:MCON RS09615
gene id: 990316:MCON_RS09615
uniprot id: F4BXZ8
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS09640
gene id: 990316:MCON_RS09640
uniprot id: F4BY03
names: Similarity
messages: Belongs to the HisA/HisF family.

990316:MCON RS10970
gene id: 990316:MCON_RS10970
uniprot id: F4BZD3
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

990316:MCON RS16790
gene id: 990316:MCON_RS16790
uniprot id: F4BWC9
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS10585
gene id: 990316:MCON_RS10585
uniprot id: F4BYY8
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS13505
gene id: 990316:MCON_RS13505
uniprot id: F4BUA3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

990316:MCON RS09015
gene id: 990316:MCON_RS09015
uniprot id: F4BX84
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS06285
gene id: 990316:MCON_RS06285
uniprot id: F4BTC3
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

990316:MCON RS02005
gene id: 990316:MCON_RS02005
uniprot id: F4BWJ9
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS13705
gene id: 990316:MCON_RS13705
uniprot id: F4BUE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

990316:MCON RS01920
gene id: 990316:MCON_RS01920
uniprot id: F4BWI3
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS07745
gene id: 990316:MCON_RS07745
uniprot id: F4BVG5
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS12680
gene id: 990316:MCON_RS12680
uniprot id: F4BT35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

990316:MCON RS05375
gene id: 990316:MCON_RS05375
uniprot id: F4C067
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

990316:MCON RS03895
gene id: 990316:MCON_RS03895
uniprot id: F4BYP9
names: Similarity
messages: Belongs to the AAA ATPase family.

990316:MCON RS13580
gene id: 990316:MCON_RS13580
uniprot id: F4BUB7
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

990316:MCON RS02435
gene id: 990316:MCON_RS02435
uniprot id: F4BX09
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

990316:MCON RS12700
gene id: 990316:MCON_RS12700
uniprot id: F4BT39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

990316:MCON RS08455
gene id: 990316:MCON_RS08455
uniprot id: F4BWQ3
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

990316:MCON RS01975
gene id: 990316:MCON_RS01975
uniprot id: F4BWJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

990316:MCON RS11545
gene id: 990316:MCON_RS11545
uniprot id: F4BZX1
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

990316:MCON RS02400
gene id: 990316:MCON_RS02400
uniprot id: F4BX02
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

990316:MCON RS05660
gene id: 990316:MCON_RS05660
uniprot id: F4C0J9
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS09770
gene id: 990316:MCON_RS09770
uniprot id: F4BY29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

990316:MCON RS14865
gene id: 990316:MCON_RS14865
uniprot id: F4BWE7
names: Similarity
messages: Belongs to the peptidase S8 family.

990316:MCON RS10670
gene id: 990316:MCON_RS10670
uniprot id: F4BZ02
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

990316:MCON RS07905
gene id: 990316:MCON_RS07905
uniprot id: F4BVJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

990316:MCON RS13020
gene id: 990316:MCON_RS13020
uniprot id: F4BTK3
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS02755
gene id: 990316:MCON_RS02755
uniprot id: F4BXF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

990316:MCON RS02585
gene id: 990316:MCON_RS02585
uniprot id: F4BXB6
names: Subcellular Location Annotation
messages: Cytoplasm

990316:MCON RS11460
gene id: 990316:MCON_RS11460
uniprot id: F4BZV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

990316:MCON RS05920
gene id: 990316:MCON_RS05920
uniprot id: F4BSV0
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

990316:MCON RS12625
gene id: 990316:MCON_RS12625
uniprot id: F4BT24
names: Similarity
messages: Belongs to the class-I fumarase family.

990316:MCON RS13005
gene id: 990316:MCON_RS13005
uniprot id: F4BTK0
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS05460
gene id: 990316:MCON_RS05460
uniprot id: F4C0G2
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

990316:MCON RS10940
gene id: 990316:MCON_RS10940
uniprot id: F4BZC7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

990316:MCON RS02175
gene id: 990316:MCON_RS02175
uniprot id: F4BWV8
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

990316:MCON RS04320
gene id: 990316:MCON_RS04320
uniprot id: F4BZ50
names: Similarity
messages: Belongs to the HsdR family.

990316:MCON RS10720
gene id: 990316:MCON_RS10720
uniprot id: F4BZ11
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

990316:MCON RS04420
gene id: 990316:MCON_RS04420
uniprot id: F4BZ74
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS00460
gene id: 990316:MCON_RS00460
uniprot id: F4BTZ0
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

990316:MCON RS04940
gene id: 990316:MCON_RS04940
uniprot id: F4BZQ0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

990316:MCON RS11500
gene id: 990316:MCON_RS11500
uniprot id: F4BZW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

990316:MCON RS11485
gene id: 990316:MCON_RS11485
uniprot id: F4BZW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

990316:MCON RS03140
gene id: 990316:MCON_RS03140
uniprot id: F4BXV4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

990316:MCON RS12365
gene id: 990316:MCON_RS12365
uniprot id: F4C0T2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

990316:MCON RS05405
gene id: 990316:MCON_RS05405
uniprot id: F4C073
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS11465
gene id: 990316:MCON_RS11465
uniprot id: F4BZV6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

990316:MCON RS13935
gene id: 990316:MCON_RS13935
uniprot id: F4BUZ4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

990316:MCON RS13765
gene id: 990316:MCON_RS13765
uniprot id: F4BUF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

990316:MCON RS14230
gene id: 990316:MCON_RS14230
uniprot id: F4BVK7
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

990316:MCON RS13350
gene id: 990316:MCON_RS13350
uniprot id: F4BTR5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

990316:MCON RS05510
gene id: 990316:MCON_RS05510
uniprot id: F4C0H1
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS08360
gene id: 990316:MCON_RS08360
uniprot id: F4BWN6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS06355
gene id: 990316:MCON_RS06355
uniprot id: F4BTD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

990316:MCON RS08185
gene id: 990316:MCON_RS08185
uniprot id: F4BW55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

990316:MCON RS06655
gene id: 990316:MCON_RS06655
uniprot id: F4BU02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

990316:MCON RS06905
gene id: 990316:MCON_RS06905
uniprot id: F4BU45
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

990316:MCON RS00435
gene id: 990316:MCON_RS00435
uniprot id: F4BTY5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

990316:MCON RS04505
gene id: 990316:MCON_RS04505
uniprot id: F4BZ89
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

990316:MCON RS11190
gene id: 990316:MCON_RS11190
uniprot id: F4BZH7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

990316:MCON RS02430
gene id: 990316:MCON_RS02430
uniprot id: F4BX08
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS13065
gene id: 990316:MCON_RS13065
uniprot id: F4BTL0
names: Similarity
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.

990316:MCON RS06910
gene id: 990316:MCON_RS06910
uniprot id: F4BU46
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS04780
gene id: 990316:MCON_RS04780
uniprot id: F4BZL8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

990316:MCON RS11035
gene id: 990316:MCON_RS11035
uniprot id: F4BZE6
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS11340
gene id: 990316:MCON_RS11340
uniprot id: F4BZT2
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

990316:MCON RS11415
gene id: 990316:MCON_RS11415
uniprot id: F4BZU6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

990316:MCON RS11385
gene id: 990316:MCON_RS11385
uniprot id: F4BZU0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

990316:MCON RS13190
gene id: 990316:MCON_RS13190
uniprot id: F4BTN5
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS05380
gene id: 990316:MCON_RS05380
uniprot id: F4C068
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

990316:MCON RS03270
gene id: 990316:MCON_RS03270
uniprot id: F4BXY1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

990316:MCON RS04810
gene id: 990316:MCON_RS04810
uniprot id: F4BZM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

990316:MCON RS10885
gene id: 990316:MCON_RS10885
uniprot id: F4BZB8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

990316:MCON RS10630
gene id: 990316:MCON_RS10630
uniprot id: F4BYZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

990316:MCON RS01570
gene id: 990316:MCON_RS01570
uniprot id: F4BVX4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

990316:MCON RS10280
gene id: 990316:MCON_RS10280
uniprot id: F4BYK3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

990316:MCON RS15045
gene id: 990316:MCON_RS15045
uniprot id: F4BXH4
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

990316:MCON RS06955
gene id: 990316:MCON_RS06955
uniprot id: F4BU54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

990316:MCON RS07090
gene id: 990316:MCON_RS07090
uniprot id: F4BU78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

990316:MCON RS08045
gene id: 990316:MCON_RS08045
uniprot id: F4BW30
names: Similarity
messages: Belongs to the GARS family.

990316:MCON RS14615
gene id: 990316:MCON_RS14615
uniprot id: F4BW94
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

990316:MCON RS02765
gene id: 990316:MCON_RS02765
uniprot id: F4BXF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

990316:MCON RS02915
gene id: 990316:MCON_RS02915
uniprot id: F4BXI0
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS03725
gene id: 990316:MCON_RS03725
uniprot id: F4BYD5
names: Similarity
messages: Belongs to the UPF0175 family.

990316:MCON RS04630
gene id: 990316:MCON_RS04630
uniprot id: F4BZJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

990316:MCON RS11920
gene id: 990316:MCON_RS11920
uniprot id: F4C0C1
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS04755
gene id: 990316:MCON_RS04755
uniprot id: F4BZL3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

990316:MCON RS13205
gene id: 990316:MCON_RS13205
uniprot id: F4BTN8
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS04605
gene id: 990316:MCON_RS04605
uniprot id: F4BZA7
names: Similarity
messages: Belongs to the UPF0285 family.

990316:MCON RS05200
gene id: 990316:MCON_RS05200
uniprot id: F4C033
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

990316:MCON RS07315
gene id: 990316:MCON_RS07315
uniprot id: F4BUT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

990316:MCON RS10480
gene id: 990316:MCON_RS10480
uniprot id: F4BYW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

990316:MCON RS08300
gene id: 990316:MCON_RS08300
uniprot id: F4BW78
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

990316:MCON RS06175
gene id: 990316:MCON_RS06175
uniprot id: F4BSZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

990316:MCON RS08175
gene id: 990316:MCON_RS08175
uniprot id: F4BW53
names: Similarity
messages: Belongs to the phosphoribulokinase family.

990316:MCON RS00090
gene id: 990316:MCON_RS00090
uniprot id: F4BTA6
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

990316:MCON RS12965
gene id: 990316:MCON_RS12965
uniprot id: F4BT90
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

990316:MCON RS06725
gene id: 990316:MCON_RS06725
uniprot id: F4BU16
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

990316:MCON RS00020
gene id: 990316:MCON_RS00020
uniprot id: F4BT93
names: Similarity
messages: Belongs to the peptidase S8 family.

990316:MCON RS16800
gene id: 990316:MCON_RS16800
uniprot id: F4BTS8
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

990316:MCON RS05850
gene id: 990316:MCON_RS05850
uniprot id: F4BST6
names: Similarity
messages: Belongs to the UPF0235 family.

990316:MCON RS08985
gene id: 990316:MCON_RS08985
uniprot id: F4BX79
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

990316:MCON RS02625
gene id: 990316:MCON_RS02625
uniprot id: F4BXC3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-96 inactivates the nitrogenase reductase and regulates nitrogenase activity.

990316:MCON RS14490
gene id: 990316:MCON_RS14490
uniprot id: F4BVR8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS11230
gene id: 990316:MCON_RS11230
uniprot id: F4BZI5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

990316:MCON RS00960
gene id: 990316:MCON_RS00960
uniprot id: F4BV55
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS02635
gene id: 990316:MCON_RS02635
uniprot id: F4BXC5
names: Similarity
messages: Belongs to the P(II) protein family.

990316:MCON RS03430
gene id: 990316:MCON_RS03430
uniprot id: F4BY86
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

990316:MCON RS03575
gene id: 990316:MCON_RS03575
uniprot id: F4BYB3
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

990316:MCON RS02545
gene id: 990316:MCON_RS02545
uniprot id: F4BX30
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS08895
gene id: 990316:MCON_RS08895
uniprot id: F4BX63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS08620
gene id: 990316:MCON_RS08620
uniprot id: F4BWT2
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

990316:MCON RS03275
gene id: 990316:MCON_RS03275
uniprot id: F4BXY2
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

990316:MCON RS12715
gene id: 990316:MCON_RS12715
uniprot id: F4BT42
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

990316:MCON RS06185
gene id: 990316:MCON_RS06185
uniprot id: F4BSZ8
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

990316:MCON RS02065
gene id: 990316:MCON_RS02065
uniprot id: F4BWL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

990316:MCON RS03945
gene id: 990316:MCON_RS03945
uniprot id: F4BYQ8
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

990316:MCON RS10285
gene id: 990316:MCON_RS10285
uniprot id: F4BYK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

990316:MCON RS02760
gene id: 990316:MCON_RS02760
uniprot id: F4BXF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

990316:MCON RS11395
gene id: 990316:MCON_RS11395
uniprot id: F4BZU2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

990316:MCON RS15340
gene id: 990316:MCON_RS15340
uniprot id: F4C0N5
names: Similarity
messages: Belongs to the acylphosphatase family.

990316:MCON RS05565
gene id: 990316:MCON_RS05565
uniprot id: F4C0I0
names: Similarity
messages: Belongs to the TrpF family.

990316:MCON RS10890
gene id: 990316:MCON_RS10890
uniprot id: F4BZB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

990316:MCON RS00640
gene id: 990316:MCON_RS00640
uniprot id: F4BUI2
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

990316:MCON RS04600
gene id: 990316:MCON_RS04600
uniprot id: F4BZA6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS03870
gene id: 990316:MCON_RS03870
uniprot id: F4BYP4
names: Similarity
messages: Belongs to the LarC family.

990316:MCON RS10920
gene id: 990316:MCON_RS10920
uniprot id: F4BZC3
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

990316:MCON RS00770
gene id: 990316:MCON_RS00770
uniprot id: F4BUK8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

990316:MCON RS02900
gene id: 990316:MCON_RS02900
uniprot id: F4BXH7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS03305
gene id: 990316:MCON_RS03305
uniprot id: F4BXY6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

990316:MCON RS08730
gene id: 990316:MCON_RS08730
uniprot id: F4BWV3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

990316:MCON RS13035
gene id: 990316:MCON_RS13035
uniprot id: F4BTK6
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS08425
gene id: 990316:MCON_RS08425
uniprot id: F4BWP7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

990316:MCON RS08885
gene id: 990316:MCON_RS08885
uniprot id: F4BX61
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

990316:MCON RS13215
gene id: 990316:MCON_RS13215
uniprot id: F4BTP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

990316:MCON RS14430
gene id: 990316:MCON_RS14430
uniprot id: F4BVQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

990316:MCON RS12955
gene id: 990316:MCON_RS12955
uniprot id: F4BT88
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS04565
gene id: 990316:MCON_RS04565
uniprot id: F4BZ99
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS10760
gene id: 990316:MCON_RS10760
uniprot id: F4BZ18
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS08900
gene id: 990316:MCON_RS08900
uniprot id: F4BX64
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS10880
gene id: 990316:MCON_RS10880
uniprot id: F4BZB7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

990316:MCON RS12620
gene id: 990316:MCON_RS12620
uniprot id: F4BT23
names: Similarity
messages: Belongs to the class-I fumarase family.

990316:MCON RS06140
gene id: 990316:MCON_RS06140
uniprot id: F4BSZ0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

990316:MCON RS06235
gene id: 990316:MCON_RS06235
uniprot id: F4BT08
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS04985
gene id: 990316:MCON_RS04985
uniprot id: F4BZQ9
names: Similarity
messages: In the N-terminal section; belongs to the DHBP synthase family.

990316:MCON RS00905
gene id: 990316:MCON_RS00905
uniprot id: F4BUN5
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

990316:MCON RS09110
gene id: 990316:MCON_RS09110
uniprot id: F4BXA1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS13210
gene id: 990316:MCON_RS13210
uniprot id: F4BTN9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS11530
gene id: 990316:MCON_RS11530
uniprot id: F4BZW8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS06740
gene id: 990316:MCON_RS06740
uniprot id: F4BU19
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

990316:MCON RS10635
gene id: 990316:MCON_RS10635
uniprot id: F4BYZ7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

990316:MCON RS00005
gene id: 990316:MCON_RS00005
uniprot id: F4BT91
names: Similarity
messages: Belongs to the peptidase S8 family.

990316:MCON RS09785
gene id: 990316:MCON_RS09785
uniprot id: F4BY31
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

990316:MCON RS04375
gene id: 990316:MCON_RS04375
uniprot id: F4BZ63
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

990316:MCON RS04620
gene id: 990316:MCON_RS04620
uniprot id: F4BZB0
names: Similarity
messages: Belongs to the MtrH family.

990316:MCON RS00965
gene id: 990316:MCON_RS00965
uniprot id: F4BV56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

990316:MCON RS09820
gene id: 990316:MCON_RS09820
uniprot id: F4BY36
names: Similarity
messages: Belongs to the AAA ATPase family.

990316:MCON RS05715
gene id: 990316:MCON_RS05715
uniprot id: F4C0K9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

990316:MCON RS12075
gene id: 990316:MCON_RS12075
uniprot id: F4C0F1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS04490
gene id: 990316:MCON_RS04490
uniprot id: F4BZ86
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

990316:MCON RS04580
gene id: 990316:MCON_RS04580
uniprot id: F4BZA2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

990316:MCON RS11060
gene id: 990316:MCON_RS11060
uniprot id: F4BZF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

990316:MCON RS13255
gene id: 990316:MCON_RS13255
uniprot id: F4BTP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

990316:MCON RS03565
gene id: 990316:MCON_RS03565
uniprot id: F4BYB1
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS11240
gene id: 990316:MCON_RS11240
uniprot id: F4BZI7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

990316:MCON RS06720
gene id: 990316:MCON_RS06720
uniprot id: F4BU15
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

990316:MCON RS10845
gene id: 990316:MCON_RS10845
uniprot id: F4BZ34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS07275
gene id: 990316:MCON_RS07275
uniprot id: F4BUS2
names: Similarity
messages: Belongs to the acylphosphatase family.

990316:MCON RS04010
gene id: 990316:MCON_RS04010
uniprot id: F4BYR9
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS05865
gene id: 990316:MCON_RS05865
uniprot id: F4BST9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

990316:MCON RS07160
gene id: 990316:MCON_RS07160
uniprot id: F4BUP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

990316:MCON RS13895
gene id: 990316:MCON_RS13895
uniprot id: F4BUY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

990316:MCON RS12975
gene id: 990316:MCON_RS12975
uniprot id: F4BTJ6
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

990316:MCON RS06390
gene id: 990316:MCON_RS06390
uniprot id: F4BTE3
names: Subcellular Location Annotation
messages: Cytoplasm

990316:MCON RS06935
gene id: 990316:MCON_RS06935
uniprot id: F4BU50
names: Similarity
messages: Belongs to the eIF-2-alpha family.

990316:MCON RS05760
gene id: 990316:MCON_RS05760
uniprot id: F4C0L8
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

990316:MCON RS06990
gene id: 990316:MCON_RS06990
uniprot id: F4BU60
names: Similarity
messages: Belongs to the DMRL synthase family.

990316:MCON RS05170
gene id: 990316:MCON_RS05170
uniprot id: F4C026
names: Similarity
messages: Belongs to the ectoine synthase family.

990316:MCON RS03210
gene id: 990316:MCON_RS03210
uniprot id: F4BXX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

990316:MCON RS04760
gene id: 990316:MCON_RS04760
uniprot id: F4BZL4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

990316:MCON RS05440
gene id: 990316:MCON_RS05440
uniprot id: F4C0F9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS11870
gene id: 990316:MCON_RS11870
uniprot id: F4C0B3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

990316:MCON RS10275
gene id: 990316:MCON_RS10275
uniprot id: F4BYK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

990316:MCON RS07180
gene id: 990316:MCON_RS07180
uniprot id: F4BUQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

990316:MCON RS10755
gene id: 990316:MCON_RS10755
uniprot id: F4BZ17
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS13135
gene id: 990316:MCON_RS13135
uniprot id: F4BTM4
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

990316:MCON RS13570
gene id: 990316:MCON_RS13570
uniprot id: F4BUB5
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

990316:MCON RS06875
gene id: 990316:MCON_RS06875
uniprot id: F4BU39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

990316:MCON RS11720
gene id: 990316:MCON_RS11720
uniprot id: F4C083
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

990316:MCON RS12420
gene id: 990316:MCON_RS12420
uniprot id: F4C0U2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

990316:MCON RS11155
gene id: 990316:MCON_RS11155
uniprot id: F4BZH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

990316:MCON RS09835
gene id: 990316:MCON_RS09835
uniprot id: F4BY38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

990316:MCON RS09025
gene id: 990316:MCON_RS09025
uniprot id: F4BX86
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

990316:MCON RS01370
gene id: 990316:MCON_RS01370
uniprot id: F4BVT9
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

990316:MCON RS01235
gene id: 990316:MCON_RS01235
uniprot id: F4BVA7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS06385
gene id: 990316:MCON_RS06385
uniprot id: F4BTE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

990316:MCON RS05570
gene id: 990316:MCON_RS05570
uniprot id: F4C0I1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

990316:MCON RS05315
gene id: 990316:MCON_RS05315
uniprot id: F4C055
names: Similarity
messages: Belongs to the UPF0146 family.

990316:MCON RS14420
gene id: 990316:MCON_RS14420
uniprot id: F4BVQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS13160
gene id: 990316:MCON_RS13160
uniprot id: F4BTM9
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

990316:MCON RS02300
gene id: 990316:MCON_RS02300
uniprot id: F4BWY2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

990316:MCON RS10150
gene id: 990316:MCON_RS10150
uniprot id: F4BYH9
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS14535
gene id: 990316:MCON_RS14535
uniprot id: F4BVS6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

990316:MCON RS11375
gene id: 990316:MCON_RS11375
uniprot id: F4BZT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

990316:MCON RS03325
gene id: 990316:MCON_RS03325
uniprot id: F4BXY9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

990316:MCON RS13930
gene id: 990316:MCON_RS13930
uniprot id: F4BUZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

990316:MCON RS06215
gene id: 990316:MCON_RS06215
uniprot id: F4BT04
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

990316:MCON RS01930
gene id: 990316:MCON_RS01930
uniprot id: F4BWI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

990316:MCON RS09635
gene id: 990316:MCON_RS09635
uniprot id: F4BY02
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

990316:MCON RS11050
gene id: 990316:MCON_RS11050
uniprot id: F4BZE9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS02580
gene id: 990316:MCON_RS02580
uniprot id: F4BXB5
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS00115
gene id: 990316:MCON_RS00115
uniprot id: F4BTB1
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

990316:MCON RS02570
gene id: 990316:MCON_RS02570
uniprot id: F4BSV2
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

990316:MCON RS11440
gene id: 990316:MCON_RS11440
uniprot id: F4BZV1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

990316:MCON RS00605
gene id: 990316:MCON_RS00605
uniprot id: F4BUH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

990316:MCON RS12345
gene id: 990316:MCON_RS12345
uniprot id: F4C0S8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

990316:MCON RS12730
gene id: 990316:MCON_RS12730
uniprot id: F4BT45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

990316:MCON RS11795
gene id: 990316:MCON_RS11795
uniprot id: F4C098
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

990316:MCON RS06830
gene id: 990316:MCON_RS06830
uniprot id: F4BU30
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS08825
gene id: 990316:MCON_RS08825
uniprot id: F4BX51
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

990316:MCON RS08415
gene id: 990316:MCON_RS08415
uniprot id: F4BWP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

990316:MCON RS00335
gene id: 990316:MCON_RS00335
uniprot id: F4BTW5
names: Similarity
messages: Belongs to the HsdR family.

990316:MCON RS09780
gene id: 990316:MCON_RS09780
uniprot id: F4BY30
names: Similarity
messages: Belongs to the UPF0047 family.

990316:MCON RS03590
gene id: 990316:MCON_RS03590
uniprot id: F4BYB8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS08050
gene id: 990316:MCON_RS08050
uniprot id: F4BW31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

990316:MCON RS15335
gene id: 990316:MCON_RS15335
uniprot id: F4C0C6
names: Similarity
messages: Belongs to the GbsR family.

990316:MCON RS09065
gene id: 990316:MCON_RS09065
uniprot id: F4BX93
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

990316:MCON RS02170
gene id: 990316:MCON_RS02170
uniprot id: F4BWV7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

990316:MCON RS03990
gene id: 990316:MCON_RS03990
uniprot id: F4BYR7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

990316:MCON RS02770
gene id: 990316:MCON_RS02770
uniprot id: F4BXF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

990316:MCON RS10180
gene id: 990316:MCON_RS10180
uniprot id: F4BYI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

990316:MCON RS13485
gene id: 990316:MCON_RS13485
uniprot id: F4BU99
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

990316:MCON RS04315
gene id: 990316:MCON_RS04315
uniprot id: F4BZ49
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS14620
gene id: 990316:MCON_RS14620
uniprot id: F4BW95
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS10385
gene id: 990316:MCON_RS10385
uniprot id: F4BYM4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

990316:MCON RS12540
gene id: 990316:MCON_RS12540
uniprot id: F4C0W0
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

990316:MCON RS08240
gene id: 990316:MCON_RS08240
uniprot id: F4BW66
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

990316:MCON RS12685
gene id: 990316:MCON_RS12685
uniprot id: F4BT36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

990316:MCON RS01410
gene id: 990316:MCON_RS01410
uniprot id: F4BVU8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

990316:MCON RS11655
gene id: 990316:MCON_RS11655
uniprot id: F4BZZ1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

990316:MCON RS01835
gene id: 990316:MCON_RS01835
uniprot id: F4BWG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

990316:MCON RS12370
gene id: 990316:MCON_RS12370
uniprot id: F4C0T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

990316:MCON RS11120
gene id: 990316:MCON_RS11120
uniprot id: F4BZG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

990316:MCON RS12005
gene id: 990316:MCON_RS12005
uniprot id: F4C0D7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

990316:MCON RS05755
gene id: 990316:MCON_RS05755
uniprot id: F4C0L7
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

990316:MCON RS08465
gene id: 990316:MCON_RS08465
uniprot id: F4BWQ5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

990316:MCON RS10070
gene id: 990316:MCON_RS10070
uniprot id: F4BXD7
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

990316:MCON RS13275
gene id: 990316:MCON_RS13275
uniprot id: F4BTQ2
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

990316:MCON RS13825
gene id: 990316:MCON_RS13825
uniprot id: F4BUX3
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

990316:MCON RS12140
gene id: 990316:MCON_RS12140
uniprot id: F4C0P1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

990316:MCON RS03665
gene id: 990316:MCON_RS03665
uniprot id: F4BYD1
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

990316:MCON RS04640
gene id: 990316:MCON_RS04640
uniprot id: F4BZJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

990316:MCON RS03600
gene id: 990316:MCON_RS03600
uniprot id: F4BYC0
names: Caution
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS09185
gene id: 990316:MCON_RS09185
uniprot id: F4BXJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

990316:MCON RS13105
gene id: 990316:MCON_RS13105
uniprot id: F4BTL7
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.

990316:MCON RS10410
gene id: 990316:MCON_RS10410
uniprot id: F4BYM9
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

990316:MCON RS04785
gene id: 990316:MCON_RS04785
uniprot id: F4BZL9
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

990316:MCON RS06940
gene id: 990316:MCON_RS06940
uniprot id: F4BU51
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

990316:MCON RS01255
gene id: 990316:MCON_RS01255
uniprot id: F4BVB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

990316:MCON RS13100
gene id: 990316:MCON_RS13100
uniprot id: F4BTL6
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS10965
gene id: 990316:MCON_RS10965
uniprot id: F4BZD2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

990316:MCON RS09585
gene id: 990316:MCON_RS09585
uniprot id: F4BXR6
names: Similarity
messages: Belongs to the UPF0045 family.

990316:MCON RS06460
gene id: 990316:MCON_RS06460
uniprot id: F4BTF7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

990316:MCON RS04960
gene id: 990316:MCON_RS04960
uniprot id: F4BZQ4
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

990316:MCON RS07630
gene id: 990316:MCON_RS07630
uniprot id: F4BVE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

990316:MCON RS07715
gene id: 990316:MCON_RS07715
uniprot id: F4BVF9
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS05685
gene id: 990316:MCON_RS05685
uniprot id: F4C0K4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

990316:MCON RS01810
gene id: 990316:MCON_RS01810
uniprot id: F4BWG3
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

990316:MCON RS12820
gene id: 990316:MCON_RS12820
uniprot id: F4BT62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

990316:MCON RS05885
gene id: 990316:MCON_RS05885
uniprot id: F4BSU3
names: Subunit
messages: Homotetramer.

990316:MCON RS03965
gene id: 990316:MCON_RS03965
uniprot id: F4BYR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

990316:MCON RS05470
gene id: 990316:MCON_RS05470
uniprot id: F4C0G4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

990316:MCON RS05630
gene id: 990316:MCON_RS05630
uniprot id: F4C0J3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

990316:MCON RS09990
gene id: 990316:MCON_RS09990
uniprot id: F4BY69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

990316:MCON RS07240
gene id: 990316:MCON_RS07240
uniprot id: F4BUR5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

990316:MCON RS04965
gene id: 990316:MCON_RS04965
uniprot id: F4BZQ5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

990316:MCON RS13235
gene id: 990316:MCON_RS13235
uniprot id: F4BTP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

990316:MCON RS06335
gene id: 990316:MCON_RS06335
uniprot id: F4BTD2
names: Cofactor
messages: Binds 1 zinc ion per subunit.

990316:MCON RS06695
gene id: 990316:MCON_RS06695
uniprot id: F4BU10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

990316:MCON RS08090
gene id: 990316:MCON_RS08090
uniprot id: F4BW37
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

990316:MCON RS15375
gene id: 990316:MCON_RS15375
uniprot id: F4BTQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

990316:MCON RS08110
gene id: 990316:MCON_RS08110
uniprot id: F4BW41
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

990316:MCON RS08940
gene id: 990316:MCON_RS08940
uniprot id: F4BX71
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

990316:MCON RS14175
gene id: 990316:MCON_RS14175
uniprot id: F4BV40
names: Similarity
messages: Belongs to the HerA family.

990316:MCON RS06590
gene id: 990316:MCON_RS06590
uniprot id: F4BTI2
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS08865
gene id: 990316:MCON_RS08865
uniprot id: F4BX58
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS13910
gene id: 990316:MCON_RS13910
uniprot id: F4BUY9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

990316:MCON RS14070
gene id: 990316:MCON_RS14070
uniprot id: F4BV18
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS09135
gene id: 990316:MCON_RS09135
uniprot id: F4BXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

990316:MCON RS04680
gene id: 990316:MCON_RS04680
uniprot id: F4BZK0
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

990316:MCON RS03970
gene id: 990316:MCON_RS03970
uniprot id: F4BYR3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

990316:MCON RS07410
gene id: 990316:MCON_RS07410
uniprot id: F4BUU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

990316:MCON RS07215
gene id: 990316:MCON_RS07215
uniprot id: F4BUR0
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

990316:MCON RS04185
gene id: 990316:MCON_RS04185
uniprot id: F4BYV2
names: Similarity
messages: Belongs to the group II decarboxylase family.

990316:MCON RS03455
gene id: 990316:MCON_RS03455
uniprot id: F4BY91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

990316:MCON RS04525
gene id: 990316:MCON_RS04525
uniprot id: F4BZ93
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

990316:MCON RS11605
gene id: 990316:MCON_RS11605
uniprot id: F4BZY1
names: Similarity
messages: Belongs to the sulfatase family.

990316:MCON RS03865
gene id: 990316:MCON_RS03865
uniprot id: F4BYP3
names: Function
messages: Part of a potassium transport system.

990316:MCON RS12640
gene id: 990316:MCON_RS12640
uniprot id: F4BT27
names: Similarity
messages: Belongs to the archaeal-type GPI family.

990316:MCON RS08020
gene id: 990316:MCON_RS08020
uniprot id: F4BW25
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS03330
gene id: 990316:MCON_RS03330
uniprot id: F4BXZ0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

990316:MCON RS13330
gene id: 990316:MCON_RS13330
uniprot id: F4BTR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

990316:MCON RS06465
gene id: 990316:MCON_RS06465
uniprot id: F4BTF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

990316:MCON RS03950
gene id: 990316:MCON_RS03950
uniprot id: F4BYQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

990316:MCON RS12590
gene id: 990316:MCON_RS12590
uniprot id: F4BT17
names: Similarity
messages: Belongs to the UPF0215 family.

990316:MCON RS13470
gene id: 990316:MCON_RS13470
uniprot id: F4BU96
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

990316:MCON RS11580
gene id: 990316:MCON_RS11580
uniprot id: F4BZX7
names: Similarity
messages: Belongs to the peptidase M20A family.

990316:MCON RS13465
gene id: 990316:MCON_RS13465
uniprot id: F4BU95
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

990316:MCON RS12970
gene id: 990316:MCON_RS12970
uniprot id: F4BTJ5
names: Similarity
messages: Belongs to the complex I subunit 3 family.

990316:MCON RS09050
gene id: 990316:MCON_RS09050
uniprot id: F4BX90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

990316:MCON RS13260
gene id: 990316:MCON_RS13260
uniprot id: F4BTP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

990316:MCON RS13240
gene id: 990316:MCON_RS13240
uniprot id: F4BTP5
names: Similarity
messages: Belongs to the UPF0201 family.

990316:MCON RS02390
gene id: 990316:MCON_RS02390
uniprot id: F4BX00
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

990316:MCON RS00530
gene id: 990316:MCON_RS00530
uniprot id: F4BUG1
names: Similarity
messages: Belongs to the glutamine synthetase family.

990316:MCON RS07885
gene id: 990316:MCON_RS07885
uniprot id: F4BVJ2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

990316:MCON RS11125
gene id: 990316:MCON_RS11125
uniprot id: F4BZG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

990316:MCON RS13405
gene id: 990316:MCON_RS13405
uniprot id: F4BU83
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

990316:MCON RS13010
gene id: 990316:MCON_RS13010
uniprot id: F4BTK1
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS04805
gene id: 990316:MCON_RS04805
uniprot id: F4BZM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS11380
gene id: 990316:MCON_RS11380
uniprot id: F4BZT9
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS00150
gene id: 990316:MCON_RS00150
uniprot id: F4BTS4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

990316:MCON RS05030
gene id: 990316:MCON_RS05030
uniprot id: F4BZZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

990316:MCON RS06420
gene id: 990316:MCON_RS06420
uniprot id: F4BTE9
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

990316:MCON RS08120
gene id: 990316:MCON_RS08120
uniprot id: F4BW43
names: Similarity
messages: Belongs to the thioesterase PaaI family.

990316:MCON RS00675
gene id: 990316:MCON_RS00675
uniprot id: F4BUI9
names: Similarity
messages: Belongs to the catalase family.

990316:MCON RS01300
gene id: 990316:MCON_RS01300
uniprot id: F4BVB8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

990316:MCON RS08680
gene id: 990316:MCON_RS08680
uniprot id: F4BWU3
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

990316:MCON RS11410
gene id: 990316:MCON_RS11410
uniprot id: F4BZU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

990316:MCON RS04955
gene id: 990316:MCON_RS04955
uniprot id: F4BZQ3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS10665
gene id: 990316:MCON_RS10665
uniprot id: F4BZ01
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

990316:MCON RS03685
gene id: 990316:MCON_RS03685
uniprot id: F4BYD5
names: Similarity
messages: Belongs to the UPF0175 family.

990316:MCON RS13300
gene id: 990316:MCON_RS13300
uniprot id: F4BTQ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

990316:MCON RS05335
gene id: 990316:MCON_RS05335
uniprot id: F4C059
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

990316:MCON RS11300
gene id: 990316:MCON_RS11300
uniprot id: F4BZS4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

990316:MCON RS13365
gene id: 990316:MCON_RS13365
uniprot id: F4BTR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

990316:MCON RS00940
gene id: 990316:MCON_RS00940
uniprot id: F4BV51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

990316:MCON RS05845
gene id: 990316:MCON_RS05845
uniprot id: F4BST5
names: Similarity
messages: Belongs to the UPF0292 family.

990316:MCON RS03635
gene id: 990316:MCON_RS03635
uniprot id: F4BYC5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

990316:MCON RS14485
gene id: 990316:MCON_RS14485
uniprot id: F4BVR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

990316:MCON RS13060
gene id: 990316:MCON_RS13060
uniprot id: F4BTK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

990316:MCON RS11275
gene id: 990316:MCON_RS11275
uniprot id: F4BZR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

990316:MCON RS08105
gene id: 990316:MCON_RS08105
uniprot id: F4BW40
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

990316:MCON RS04530
gene id: 990316:MCON_RS04530
uniprot id: F4BZ94
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

990316:MCON RS09485
gene id: 990316:MCON_RS09485
uniprot id: F4BXP9
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS13710
gene id: 990316:MCON_RS13710
uniprot id: F4BUE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

990316:MCON RS05475
gene id: 990316:MCON_RS05475
uniprot id: F4C0G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

990316:MCON RS04950
gene id: 990316:MCON_RS04950
uniprot id: F4BZQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

990316:MCON RS11570
gene id: 990316:MCON_RS11570
uniprot id: F4BZX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

990316:MCON RS06865
gene id: 990316:MCON_RS06865
uniprot id: F4BU37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

990316:MCON RS07335
gene id: 990316:MCON_RS07335
uniprot id: F4BUT4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

990316:MCON RS00885
gene id: 990316:MCON_RS00885
uniprot id: F4BUN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

990316:MCON RS09930
gene id: 990316:MCON_RS09930
uniprot id: F4BY57
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

990316:MCON RS02455
gene id: 990316:MCON_RS02455
uniprot id: F4BX13
names: Similarity
messages: Belongs to the UPF0284 family.

990316:MCON RS09730
gene id: 990316:MCON_RS09730
uniprot id: F4BY22
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

990316:MCON RS12800
gene id: 990316:MCON_RS12800
uniprot id: F4BT58
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

990316:MCON RS08040
gene id: 990316:MCON_RS08040
uniprot id: F4BW29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

990316:MCON RS14225
gene id: 990316:MCON_RS14225
uniprot id: F4BVK6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

990316:MCON RS05655
gene id: 990316:MCON_RS05655
uniprot id: F4C0J8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

990316:MCON RS00870
gene id: 990316:MCON_RS00870
uniprot id: F4BUM8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

990316:MCON RS07340
gene id: 990316:MCON_RS07340
uniprot id: F4BUT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

990316:MCON RS12290
gene id: 990316:MCON_RS12290
uniprot id: F4C0R9
names: Similarity
messages: Belongs to the peptidase U62 family.

990316:MCON RS13515
gene id: 990316:MCON_RS13515
uniprot id: F4BUA6
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS07855
gene id: 990316:MCON_RS07855
uniprot id: F4BVI7
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS11090
gene id: 990316:MCON_RS11090
uniprot id: F4BZF7
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

990316:MCON RS10395
gene id: 990316:MCON_RS10395
uniprot id: F4BYM6
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

990316:MCON RS00540
gene id: 990316:MCON_RS00540
uniprot id: F4BUG3
names: Similarity
messages: Belongs to the glutamate synthase family.

990316:MCON RS10695
gene id: 990316:MCON_RS10695
uniprot id: F4BZ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

990316:MCON RS11450
gene id: 990316:MCON_RS11450
uniprot id: F4BZV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

990316:MCON RS13395
gene id: 990316:MCON_RS13395
uniprot id: F4BU81
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

990316:MCON RS04645
gene id: 990316:MCON_RS04645
uniprot id: F4BZJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

990316:MCON RS14850
gene id: 990316:MCON_RS14850
uniprot id: F4BWE4
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

990316:MCON RS12180
gene id: 990316:MCON_RS12180
uniprot id: F4C0P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

990316:MCON RS11610
gene id: 990316:MCON_RS11610
uniprot id: F4BZY2
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

990316:MCON RS06030
gene id: 990316:MCON_RS06030
uniprot id: F4BSW9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

990316:MCON RS08995
gene id: 990316:MCON_RS08995
uniprot id: F4BX81
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

990316:MCON RS12215
gene id: 990316:MCON_RS12215
uniprot id: F4C0Q5
names: Similarity
messages: Belongs to the MtrH family.

990316:MCON RS11575
gene id: 990316:MCON_RS11575
uniprot id: F4BZX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

990316:MCON RS02630
gene id: 990316:MCON_RS02630
uniprot id: F4BXC4
names: Similarity
messages: Belongs to the P(II) protein family.

990316:MCON RS05695
gene id: 990316:MCON_RS05695
uniprot id: F4C0K6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

990316:MCON RS11175
gene id: 990316:MCON_RS11175
uniprot id: F4BZH4
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS14595
gene id: 990316:MCON_RS14595
uniprot id: F4BW90
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

990316:MCON RS06195
gene id: 990316:MCON_RS06195
uniprot id: F4BT00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

990316:MCON RS03145
gene id: 990316:MCON_RS03145
uniprot id: F4BXV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

990316:MCON RS14235
gene id: 990316:MCON_RS14235
uniprot id: F4BVK8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

990316:MCON RS11725
gene id: 990316:MCON_RS11725
uniprot id: F4C084
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

990316:MCON RS10925
gene id: 990316:MCON_RS10925
uniprot id: F4BZC4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

990316:MCON RS07680
gene id: 990316:MCON_RS07680
uniprot id: F4BVF2
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS06900
gene id: 990316:MCON_RS06900
uniprot id: F4BU44
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

990316:MCON RS13565
gene id: 990316:MCON_RS13565
uniprot id: F4BUB4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

990316:MCON RS09205
gene id: 990316:MCON_RS09205
uniprot id: F4BSV2
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

990316:MCON RS05485
gene id: 990316:MCON_RS05485
uniprot id: F4C0G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

990316:MCON RS06290
gene id: 990316:MCON_RS06290
uniprot id: F4BTC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

990316:MCON RS02405
gene id: 990316:MCON_RS02405
uniprot id: F4BX03
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

990316:MCON RS01955
gene id: 990316:MCON_RS01955
uniprot id: F4BWI9
names: Similarity
messages: Belongs to the acylphosphatase family.

990316:MCON RS10870
gene id: 990316:MCON_RS10870
uniprot id: F4BZB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

990316:MCON RS02990
gene id: 990316:MCON_RS02990
uniprot id: F4BXS4
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS12830
gene id: 990316:MCON_RS12830
uniprot id: F4BT64
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

990316:MCON RS09995
gene id: 990316:MCON_RS09995
uniprot id: F4BY70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

990316:MCON RS02070
gene id: 990316:MCON_RS02070
uniprot id: F4BWL1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS06180
gene id: 990316:MCON_RS06180
uniprot id: F4BSZ7
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

990316:MCON RS01885
gene id: 990316:MCON_RS01885
uniprot id: F4BWH9
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.

990316:MCON RS00945
gene id: 990316:MCON_RS00945
uniprot id: F4BV52
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS00300
gene id: 990316:MCON_RS00300
uniprot id: F4BTV7
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

990316:MCON RS02895
gene id: 990316:MCON_RS02895
uniprot id: F4BXH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

990316:MCON RS08625
gene id: 990316:MCON_RS08625
uniprot id: F4BWT3
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS02655
gene id: 990316:MCON_RS02655
uniprot id: F4BXC9
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

990316:MCON RS01295
gene id: 990316:MCON_RS01295
uniprot id: F4BVB7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

990316:MCON RS04515
gene id: 990316:MCON_RS04515
uniprot id: F4BZ91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

990316:MCON RS11820
gene id: 990316:MCON_RS11820
uniprot id: F4BSV2
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

990316:MCON RS11100
gene id: 990316:MCON_RS11100
uniprot id: F4BZF9
names: Similarity
messages: Belongs to the Fur family.

990316:MCON RS12905
gene id: 990316:MCON_RS12905
uniprot id: F4BT79
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS11995
gene id: 990316:MCON_RS11995
uniprot id: F4C0D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

990316:MCON RS03460
gene id: 990316:MCON_RS03460
uniprot id: F4BY92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

990316:MCON RS07100
gene id: 990316:MCON_RS07100
uniprot id: F4BUN8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

990316:MCON RS08710
gene id: 990316:MCON_RS08710
uniprot id: F4BWU9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS00395
gene id: 990316:MCON_RS00395
uniprot id: F4BTX6
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

990316:MCON RS05995
gene id: 990316:MCON_RS05995
uniprot id: F4BSW2
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

990316:MCON RS06470
gene id: 990316:MCON_RS06470
uniprot id: F4BTF9
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

990316:MCON RS11140
gene id: 990316:MCON_RS11140
uniprot id: F4BZG7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

990316:MCON RS11780
gene id: 990316:MCON_RS11780
uniprot id: F4C095
names: Similarity
messages: Belongs to the thioesterase PaaI family.

990316:MCON RS04560
gene id: 990316:MCON_RS04560
uniprot id: F4BZ98
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

990316:MCON RS03240
gene id: 990316:MCON_RS03240
uniprot id: F4BXX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

990316:MCON RS05040
gene id: 990316:MCON_RS05040
uniprot id: F4BZZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

990316:MCON RS01825
gene id: 990316:MCON_RS01825
uniprot id: F4BWG6
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS12595
gene id: 990316:MCON_RS12595
uniprot id: F4BT18
names: Similarity
messages: Belongs to the acylphosphatase family.

990316:MCON RS10645
gene id: 990316:MCON_RS10645
uniprot id: F4BYZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

990316:MCON RS08200
gene id: 990316:MCON_RS08200
uniprot id: F4BW58
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

990316:MCON RS09795
gene id: 990316:MCON_RS09795
uniprot id: F4BY33
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

990316:MCON RS05495
gene id: 990316:MCON_RS05495
uniprot id: F4C0G9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

990316:MCON RS03480
gene id: 990316:MCON_RS03480
uniprot id: F4BY96
names: Similarity
messages: Belongs to the UPF0216 family.

990316:MCON RS02380
gene id: 990316:MCON_RS02380
uniprot id: F4BWZ8
names: Similarity
messages: Belongs to the UPF0212 family.

990316:MCON RS14185
gene id: 990316:MCON_RS14185
uniprot id: F4BV42
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

990316:MCON RS12070
gene id: 990316:MCON_RS12070
uniprot id: F4C0F0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

990316:MCON RS12000
gene id: 990316:MCON_RS12000
uniprot id: F4C0D6
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

990316:MCON RS14220
gene id: 990316:MCON_RS14220
uniprot id: F4BVK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

990316:MCON RS10690
gene id: 990316:MCON_RS10690
uniprot id: F4BZ06
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS05000
gene id: 990316:MCON_RS05000
uniprot id: F4BZR2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

990316:MCON RS13385
gene id: 990316:MCON_RS13385
uniprot id: F4BTS1
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

990316:MCON RS09180
gene id: 990316:MCON_RS09180
uniprot id: F4BXJ2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

990316:MCON RS07720
gene id: 990316:MCON_RS07720
uniprot id: F4BVG0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS00765
gene id: 990316:MCON_RS00765
uniprot id: F4BUK7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS01895
gene id: 990316:MCON_RS01895
uniprot id: F4BWI1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

990316:MCON RS13315
gene id: 990316:MCON_RS13315
uniprot id: F4BTR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

990316:MCON RS02525
gene id: 990316:MCON_RS02525
uniprot id: F4BX26
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

990316:MCON RS13345
gene id: 990316:MCON_RS13345
uniprot id: F4BTR4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

990316:MCON RS11470
gene id: 990316:MCON_RS11470
uniprot id: F4BZV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

990316:MCON RS00880
gene id: 990316:MCON_RS00880
uniprot id: F4BUN0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

990316:MCON RS14470
gene id: 990316:MCON_RS14470
uniprot id: F4BVR4
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS01760
gene id: 990316:MCON_RS01760
uniprot id: F4BWF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

990316:MCON RS08450
gene id: 990316:MCON_RS08450
uniprot id: F4BWQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

990316:MCON RS07440
gene id: 990316:MCON_RS07440
uniprot id: F4BUV5
names: Similarity
messages: Belongs to the SUI1 family.

990316:MCON RS10660
gene id: 990316:MCON_RS10660
uniprot id: F4BZ00
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

990316:MCON RS07785
gene id: 990316:MCON_RS07785
uniprot id: F4BVH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

990316:MCON RS00440
gene id: 990316:MCON_RS00440
uniprot id: F4BTY6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

990316:MCON RS07830
gene id: 990316:MCON_RS07830
uniprot id: F4BVI1
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS00340
gene id: 990316:MCON_RS00340
uniprot id: F4BTW6
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

990316:MCON RS07380
gene id: 990316:MCON_RS07380
uniprot id: F4BUU3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

990316:MCON RS03935
gene id: 990316:MCON_RS03935
uniprot id: F4BYQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

990316:MCON RS13695
gene id: 990316:MCON_RS13695
uniprot id: F4BUD9
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS05480
gene id: 990316:MCON_RS05480
uniprot id: F4C0G6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

990316:MCON RS13955
gene id: 990316:MCON_RS13955
uniprot id: F4BUZ8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS01315
gene id: 990316:MCON_RS01315
uniprot id: F4BVC0
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

990316:MCON RS04510
gene id: 990316:MCON_RS04510
uniprot id: F4BZ90
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS11495
gene id: 990316:MCON_RS11495
uniprot id: F4BZW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

990316:MCON RS12780
gene id: 990316:MCON_RS12780
uniprot id: F4BT54
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

990316:MCON RS13670
gene id: 990316:MCON_RS13670
uniprot id: F4BUD4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS01290
gene id: 990316:MCON_RS01290
uniprot id: F4BVB6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

990316:MCON RS12085
gene id: 990316:MCON_RS12085
uniprot id: F4C0F3
names: Caution
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS06210
gene id: 990316:MCON_RS06210
uniprot id: F4BT03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

990316:MCON RS01495
gene id: 990316:MCON_RS01495
uniprot id: F4BVV9
names: Similarity
messages: Belongs to the DtxR/MntR family.

990316:MCON RS08435
gene id: 990316:MCON_RS08435
uniprot id: F4BWP9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS13480
gene id: 990316:MCON_RS13480
uniprot id: F4BU98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

990316:MCON RS02260
gene id: 990316:MCON_RS02260
uniprot id: F4BWX4
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS01730
gene id: 990316:MCON_RS01730
uniprot id: F4BW04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

990316:MCON RS11170
gene id: 990316:MCON_RS11170
uniprot id: F4BZH3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS05025
gene id: 990316:MCON_RS05025
uniprot id: F4BZZ6
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

990316:MCON RS13620
gene id: 990316:MCON_RS13620
uniprot id: F4BUC3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

990316:MCON RS01265
gene id: 990316:MCON_RS01265
uniprot id: F4BVB1
names: Similarity
messages: Belongs to the PspA/IM30 family.

990316:MCON RS08075
gene id: 990316:MCON_RS08075
uniprot id: F4BW35
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

990316:MCON RS11490
gene id: 990316:MCON_RS11490
uniprot id: F4BZW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

990316:MCON RS04495
gene id: 990316:MCON_RS04495
uniprot id: F4BZ87
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

990316:MCON RS13815
gene id: 990316:MCON_RS13815
uniprot id: F4BUX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

990316:MCON RS06915
gene id: 990316:MCON_RS06915
uniprot id: F4BU47
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS05930
gene id: 990316:MCON_RS05930
uniprot id: F4BSV2
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

990316:MCON RS13220
gene id: 990316:MCON_RS13220
uniprot id: F4BTP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

990316:MCON RS04655
gene id: 990316:MCON_RS04655
uniprot id: F4BZJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

990316:MCON RS07330
gene id: 990316:MCON_RS07330
uniprot id: F4BUT3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

990316:MCON RS14580
gene id: 990316:MCON_RS14580
uniprot id: F4BW87
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

990316:MCON RS13435
gene id: 990316:MCON_RS13435
uniprot id: F4BU89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

990316:MCON RS13080
gene id: 990316:MCON_RS13080
uniprot id: F4BTL3
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

990316:MCON RS07790
gene id: 990316:MCON_RS07790
uniprot id: F4BVH4
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS05145
gene id: 990316:MCON_RS05145
uniprot id: F4C021
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS00655
gene id: 990316:MCON_RS00655
uniprot id: F4BUI5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

990316:MCON RS05210
gene id: 990316:MCON_RS05210
uniprot id: F4C035
names: Similarity
messages: Belongs to the gamma-class carbonic anhydrase family.

990316:MCON RS09590
gene id: 990316:MCON_RS09590
uniprot id: F4BXR7
names: Similarity
messages: Belongs to the UPF0047 family.

990316:MCON RS10530
gene id: 990316:MCON_RS10530
uniprot id: F4BYX7
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS10750
gene id: 990316:MCON_RS10750
uniprot id: F4BZ16
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS10675
gene id: 990316:MCON_RS10675
uniprot id: F4BZ03
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

990316:MCON RS01500
gene id: 990316:MCON_RS01500
uniprot id: F4BVW0
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS15075
gene id: 990316:MCON_RS15075
uniprot id: F4BYS2
names: Similarity
messages: Belongs to the peptidase C1 family.

990316:MCON RS09080
gene id: 990316:MCON_RS09080
uniprot id: F4BX96
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS02695
gene id: 990316:MCON_RS02695
uniprot id: F4BXD7
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

990316:MCON RS01530
gene id: 990316:MCON_RS01530
uniprot id: F4BVW6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS12385
gene id: 990316:MCON_RS12385
uniprot id: F4C0T6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

990316:MCON RS11150
gene id: 990316:MCON_RS11150
uniprot id: F4BZG9
names: Similarity
messages: Belongs to the PDCD5 family.

990316:MCON RS05490
gene id: 990316:MCON_RS05490
uniprot id: F4C0G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

990316:MCON RS00465
gene id: 990316:MCON_RS00465
uniprot id: F4BTZ1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS13140
gene id: 990316:MCON_RS13140
uniprot id: F4BTM5
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

990316:MCON RS07190
gene id: 990316:MCON_RS07190
uniprot id: F4BUQ5
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

990316:MCON RS01805
gene id: 990316:MCON_RS01805
uniprot id: F4BWG2
names: Caution
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS11430
gene id: 990316:MCON_RS11430
uniprot id: F4BZU9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

990316:MCON RS07460
gene id: 990316:MCON_RS07460
uniprot id: F4BUV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

990316:MCON RS05650
gene id: 990316:MCON_RS05650
uniprot id: F4C0J7
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

990316:MCON RS08335
gene id: 990316:MCON_RS08335
uniprot id: F4BWM9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

990316:MCON RS09645
gene id: 990316:MCON_RS09645
uniprot id: F4BY04
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

990316:MCON RS14155
gene id: 990316:MCON_RS14155
uniprot id: F4BV36
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS09115
gene id: 990316:MCON_RS09115
uniprot id: F4BXA2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

990316:MCON RS09925
gene id: 990316:MCON_RS09925
uniprot id: F4BY56
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS06310
gene id: 990316:MCON_RS06310
uniprot id: F4BTC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

990316:MCON RS01795
gene id: 990316:MCON_RS01795
uniprot id: F4BWG0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

990316:MCON RS13425
gene id: 990316:MCON_RS13425
uniprot id: F4BU87
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

990316:MCON RS12790
gene id: 990316:MCON_RS12790
uniprot id: F4BT56
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS12645
gene id: 990316:MCON_RS12645
uniprot id: F4BT28
names: Subcellular Location Annotation
messages: Cell membrane

990316:MCON RS00970
gene id: 990316:MCON_RS00970
uniprot id: F4BV57
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

990316:MCON RS01670
gene id: 990316:MCON_RS01670
uniprot id: F4BVZ4
names: Similarity
messages: Belongs to the UPF0288 family.

990316:MCON RS02645
gene id: 990316:MCON_RS02645
uniprot id: F4BXC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

990316:MCON RS09190
gene id: 990316:MCON_RS09190
uniprot id: F4BXJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

990316:MCON RS13940
gene id: 990316:MCON_RS13940
uniprot id: F4BUZ5
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

990316:MCON RS05515
gene id: 990316:MCON_RS05515
uniprot id: F4C0H2
names: Subcellular Location Annotation
messages: Membrane

990316:MCON RS07235
gene id: 990316:MCON_RS07235
uniprot id: F4BUR4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

990316:MCON RS01845
gene id: 990316:MCON_RS01845
uniprot id: F4BWH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

990316:MCON RS10090
gene id: 990316:MCON_RS10090
uniprot id: F4BYG7
names: Subcellular Location Annotation
messages: Membrane