9823:NAA10
gene id: 9823:NAA10
uniprot id: A0A8D1A442
uniprot id: K7GKC7
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9823:JPT2
gene id: 9823:JPT2
uniprot id: I7KJP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9823:ART5
gene id: 9823:ART5
uniprot id: F1SUY8
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9823:VAX1
gene id: 9823:VAX1
uniprot id: A0A8D1NN42
uniprot id: F1S4S0
names: Subcellular Location Annotation
messages: Nucleus

9823:MYADM
gene id: 9823:MYADM
uniprot id: A0A8D0N0H1
uniprot id: F1RNK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9823:ETFDH
gene id: 9823:ETFDH
uniprot id: A0A8D1R7K8
uniprot id: A0A8D1RC92
uniprot id: A0A8W4FK45
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9823:IGFBP1
gene id: 9823:IGFBP1
uniprot id: A0A4X1UAL4
uniprot id: E0A8P1
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:LSM5
gene id: 9823:LSM5
uniprot id: A0A4X1SQM6
uniprot id: A0A8D1D312
uniprot id: A0A8D1M2P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9823:CAPZA3
gene id: 9823:CAPZA3
uniprot id: A0A4X1V6F2
uniprot id: A0A8D0M9B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9823:TP53I11
gene id: 9823:TP53I11
uniprot id: A0A286ZVX6
uniprot id: A0A8D1R9I5
names: Subcellular Location Annotation
messages: Membrane

9823:FMC1
gene id: 9823:FMC1
uniprot id: A0A4X1V8F5
uniprot id: A0A8D1PSP4
names: Similarity
messages: Belongs to the FMC1 family.

9823:SNX21
gene id: 9823:SNX21
uniprot id: A0A8D1D249
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Membrane

9823:LOC100523744
gene id: 9823:LOC100523744
uniprot id: A0A8D0QX44
uniprot id: A0A8D1TSC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LCTL
gene id: 9823:LCTL
uniprot id: A0A4X1T8X2
uniprot id: F1SJJ3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9823:TAC4
gene id: 9823:TAC4
uniprot id: A0A8D1R6X6
uniprot id: I4IYB5
names: Similarity
messages: Belongs to the tachykinin family.

9823:ADAMTS10
gene id: 9823:ADAMTS10
uniprot id: A0A8D1IEZ8
uniprot id: F8UV45
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:ARSE
gene id: 9823:ARSE
uniprot id: A0A4X1TTK6
names: Similarity
messages: Belongs to the sulfatase family.

9823:L3MBTL2
gene id: 9823:L3MBTL2
uniprot id: A0A480PDF4
uniprot id: A0A480PHL8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

9823:AQP3
gene id: 9823:AQP3
uniprot id: A0A4X1UP82
uniprot id: A9Y006
uniprot id: F1DQZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Basolateral cell membrane
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Highly expressed in stomach and spleen, with lower expression in kidney and lung.
messages: Membrane
messages: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.

9823:SLC1A5
gene id: 9823:SLC1A5
uniprot id: A0A4X1W229
uniprot id: F1RM08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9823:MMP2
gene id: 9823:MMP2
uniprot id: Q95JA4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

9823:POLE2
gene id: 9823:POLE2
uniprot id: A0A8D0MBK3
uniprot id: F1SHZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

9823:SGTB
gene id: 9823:SGTB
uniprot id: A0A286ZNJ9
uniprot id: A0A287A0P2
uniprot id: A0A4X1UQM5
uniprot id: A0A8D2BN54
names: Similarity
messages: Belongs to the SGT family.

9823:GDF3
gene id: 9823:GDF3
uniprot id: F1SLW3
names: Similarity
messages: Belongs to the TGF-beta family.

9823:ESRRA
gene id: 9823:ESRRA
uniprot id: A0A8D0P1K0
uniprot id: D2D3P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9823:EME1
gene id: 9823:EME1
uniprot id: A0A4X1TVB1
uniprot id: F1RT80
names: Similarity
messages: Belongs to the EME1/MMS4 family.

9823:TACR3
gene id: 9823:TACR3
uniprot id: A0A4X1US65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:RAB29
gene id: 9823:RAB29
uniprot id: A0A4X1UUZ3
uniprot id: A0A8D0ND84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9823:LOC100625111
gene id: 9823:LOC100625111
uniprot id: A0A8D1M792
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100520582
gene id: 9823:LOC100520582
uniprot id: A0A4X1V7D8
uniprot id: A0A8D1B161
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9823:UGT8
gene id: 9823:UGT8
uniprot id: A0A4X1V679
uniprot id: I3LFS4
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9823:IRGQ
gene id: 9823:IRGQ
uniprot id: A0A8D1ZIH0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9823:LOC100512703
gene id: 9823:LOC100512703
uniprot id: A0A8D0RIL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CYP3A29
gene id: 9823:CYP3A29
uniprot id: P79401
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

9823:CASQ1
gene id: 9823:CASQ1
uniprot id: A0A8D1EB65
uniprot id: F1RJW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9823:C4H1orf43
gene id: 9823:C4H1orf43
uniprot id: A0A8D1W6M3
uniprot id: F1RGK8
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

9823:CNOT2
gene id: 9823:CNOT2
uniprot id: A0A4X1W0T9
uniprot id: A0A8D0MV36
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9823:SDC4
gene id: 9823:SDC4
uniprot id: A0A480JRC1
uniprot id: Q8HZJ6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
messages: Cell surface proteoglycan.
messages: Homodimer. Interacts with CDCP1 and SDCBP. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1 (By similarity).
messages: Membrane
messages: O-glycosylated; contains both chondroitin sulfate and heparan sulfate. Ser-43, Ser-65 and Ser-67 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate.
messages: Secreted
messages: Shedding, cleavage of the extracellular domain to release a soluble form, is enhanced by a number of factors such as heparanase, growth factor receptor action for example by thrombin or EGF. Physiological events such as stress or wound healing can activate the shedding. PMA-mediated shedding is inhibited by TIMP3 (By similarity).

9823:SUSD6
gene id: 9823:SUSD6
uniprot id: A0A8D0ZCX7
uniprot id: F1S4B3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:TFAM
gene id: 9823:TFAM
uniprot id: Q5D144
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA via its HMG boxes. When bound to the mitochondrial light strand promoter, bends DNA into a U-turn shape, each HMG box bending the DNA by 90 degrees (By similarity).
messages: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
messages: Mitochondrion
messages: Monomer; binds DNA as a monomer. Homodimer. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT. In this complex TFAM recruits POLRMT to the promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Upon metabolic stress, forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT. Interacts with TFB1M and TFB2M. Interacts with CLPX; this enhances DNA-binding.
messages: Phosphorylation by PKA within the HMG box 1 impairs DNA binding and promotes degradation by the AAA+ Lon protease.
messages: mitochondrion nucleoid

9823:TPM3
gene id: 9823:TPM3
uniprot id: A0A480SLY1
uniprot id: A0A4X1VV89
uniprot id: A0A4X1W0H8
uniprot id: A0A4X1W162
uniprot id: A0A5G2RD45
uniprot id: A0A8D0IB50
uniprot id: A0A8D0III7
uniprot id: A0A8D0NEU5
uniprot id: A0A8D0RAL2
uniprot id: A0A8D1BU01
uniprot id: A0A8D1BU09
uniprot id: A0A8D1KAX1
uniprot id: Q6QA25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9823:PFKFB4
gene id: 9823:PFKFB4
uniprot id: A0A480JXS5
uniprot id: A0A4X1T351
uniprot id: A0A8D0UXK2
uniprot id: A0A8D1BFL5
uniprot id: A0A8D1IKM6
uniprot id: F1SKM3
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9823:KRTCAP2
gene id: 9823:KRTCAP2
uniprot id: A0A8D1HYE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

9823:HSF5
gene id: 9823:HSF5
uniprot id: A0A8D1W7P6
uniprot id: I3LFB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9823:RPS7
gene id: 9823:RPS7
uniprot id: A0A287A9Y6
uniprot id: A0A4X1UGT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: centrosome

9823:MAN2B2
gene id: 9823:MAN2B2
uniprot id: Q28949
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.
messages: Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida.
messages: Processed into a 27 kDa fragment localized on the equatorial segment and the apical rim of the head of mature sperm.
messages: Secreted
messages: Specific to the caput and corpus of the epididymis.

9823:PMP2
gene id: 9823:PMP2
uniprot id: P86412
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol (By similarity).
messages: Monomer.
messages: P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.

9823:LOC100156339
gene id: 9823:LOC100156339
uniprot id: A0A4X1UV01
uniprot id: A0A5G2R6A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NOP56
gene id: 9823:NOP56
uniprot id: A0A4X1SJ12
uniprot id: A0A8D2A0N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9823:CPEB4
gene id: 9823:CPEB4
uniprot id: A0A286ZUJ5
uniprot id: A0A287BFV6
uniprot id: A0A4X1UDC8
uniprot id: A0A4X1UEL5
uniprot id: A0A8D0IFV8
uniprot id: A0A8D0IGI7
uniprot id: A0A8D0IGN5
uniprot id: A0A8D0TKB2
uniprot id: A0A8D1I930
names: Similarity
messages: Belongs to the RRM CPEB family.

9823:APPL2
gene id: 9823:APPL2
uniprot id: A0A8D0M6P6
uniprot id: B6DZ39
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9823:LOC100626247
gene id: 9823:LOC100626247
uniprot id: A0A480NGB4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:MOXD1
gene id: 9823:MOXD1
uniprot id: A0A8D1CCD9
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

9823:POLL
gene id: 9823:POLL
uniprot id: A0A8D1ZJX7
uniprot id: F1S8U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9823:FITM2
gene id: 9823:FITM2
uniprot id: B2LYG4
uniprot id: B8XJY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT2 subfamily.
messages: Endoplasmic reticulum membrane
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).
messages: Membrane

9823:DDIT4
gene id: 9823:DDIT4
uniprot id: A0A4X1T7U4
uniprot id: A0A8D1FQZ8
names: Similarity
messages: Belongs to the DDIT4 family.

9823:CDK2AP2
gene id: 9823:CDK2AP2
uniprot id: A0A8D1AU68
uniprot id: F1RVM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9823:CLDN22
gene id: 9823:CLDN22
uniprot id: A0A4X1VYQ0
uniprot id: C3VMW7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:PSMC6
gene id: 9823:PSMC6
uniprot id: A0A4X1W7V1
uniprot id: A0A8D0JAD6
names: Similarity
messages: Belongs to the AAA ATPase family.

9823:PDLIM1
gene id: 9823:PDLIM1
uniprot id: A0A5K1TZ27
uniprot id: A0A8D1KGW9
names: Subcellular Location Annotation
messages: Z line

9823:XPNPEP1
gene id: 9823:XPNPEP1
uniprot id: A0A480Q815
uniprot id: A0A480Y1M9
uniprot id: A0A4X1THI9
uniprot id: A0A8D0YGN2
uniprot id: K9IVF7
names: Similarity
messages: Belongs to the peptidase M24B family.

9823:DNAL4
gene id: 9823:DNAL4
uniprot id: A4F4L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein light chain family.
messages: Consists of at least two heavy chains and a number of intermediate and light chains.
messages: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).
messages: cilium axoneme

9823:ACTR6
gene id: 9823:ACTR6
uniprot id: A0A4X1SSP2
uniprot id: A0A4X1SUJ5
uniprot id: A0A8D0M8I0
uniprot id: A0A8D1CUE7
names: Similarity
messages: Belongs to the actin family.

9823:MRPL54
gene id: 9823:MRPL54
uniprot id: A0A480PHA9
uniprot id: A0A8D1ZYX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9823:LOC100518575
gene id: 9823:LOC100518575
uniprot id: A0A8D0Y8Q7
uniprot id: A0A8W4FMM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9823:SCRN1
gene id: 9823:SCRN1
uniprot id: A0A287B8Z9
uniprot id: A0A8D0ZJX2
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9823:KLHL21
gene id: 9823:KLHL21
uniprot id: A0A480RGQ1
names: Subcellular Location Annotation
messages: spindle

9823:SPATA20
gene id: 9823:SPATA20
uniprot id: A0A480WWD6
uniprot id: A0A8D1A7D3
uniprot id: A0A8D1E404
uniprot id: C1JEX8
uniprot id: F1RT97
names: Function
names: Subcellular Location Annotation
messages: May play a role in fertility regulation.
messages: Secreted

9823:TRHR
gene id: 9823:TRHR
uniprot id: D5FUH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9823:MAP3K21
gene id: 9823:MAP3K21
uniprot id: A0A4X1UG44
uniprot id: F1RGV0
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9823:CYP1A1
gene id: 9823:CYP1A1
uniprot id: A0A4X1TMV9
uniprot id: Q8SQ69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9823:DEFB125
gene id: 9823:DEFB125
uniprot id: A0A8D1BI38
uniprot id: A0A8D1M3R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:F12
gene id: 9823:F12
uniprot id: O97507
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity).
messages: Interacts with HRG; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding, inhibits factor XII autoactivation and contact-initiated coagulation.
messages: O- and N-glycosylated.
messages: Secreted

9823:SMPD2
gene id: 9823:SMPD2
uniprot id: A0A8D1SLW8
uniprot id: F1RSY4
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9823:TERF1
gene id: 9823:TERF1
uniprot id: A0A286ZMS0
uniprot id: A0A287ALL2
uniprot id: A0A4X1UIZ8
uniprot id: A0A4X1UL63
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus
messages: telomere

9823:DSCR3
gene id: 9823:DSCR3
uniprot id: A0A286ZPI7
uniprot id: A0A4X1TRV9
uniprot id: A0A8D0HWM2
uniprot id: A0A8D0UGC3
names: Similarity
messages: Belongs to the VPS26 family.

9823:ZC3HAV1
gene id: 9823:ZC3HAV1
uniprot id: A0A287B525
uniprot id: A0A4X1VAZ4
uniprot id: A0A4X1VEP1
uniprot id: D4P3C2
names: Similarity
messages: Belongs to the ARTD/PARP family.

9823:MEMO1
gene id: 9823:MEMO1
uniprot id: A0A4X1T9V9
uniprot id: F2Z5F8
names: Similarity
messages: Belongs to the MEMO1 family.

9823:PNPLA6
gene id: 9823:PNPLA6
uniprot id: A0A4X1VPJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:ALG10
gene id: 9823:ALG10
uniprot id: A0A8D0XNP1
uniprot id: I3LNP0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:ADRA1D
gene id: 9823:ADRA1D
uniprot id: Q9TTM9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Palmitoylated. Palmitoylation by ZDHHC21 may increase the expression of the receptor and regulate downstream signaling.
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

9823:PPM1F
gene id: 9823:PPM1F
uniprot id: A0A4X1V1E0
names: Similarity
messages: Belongs to the PP2C family.

9823:MBL1
gene id: 9823:MBL1
uniprot id: Q5U9S1
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine on bacteria, including strains of A.suis, H.parasuis and A.pleuropneumoniae, and activates the lectin complement pathway. According to some authors, it only binds mannose (PubMed:8602463).
messages: Detected in blood serum (at protein level) (PubMed:16480769, PubMed:16518621). Expressed in liver. Weakly expressed in lung, testis and brain. Not detected in bone marrow and heart.
messages: Hydroxylated on lysine and proline residues within the collagen-like domain.
messages: Incorrectly identified as MBL2 by PubMed:11063327.
messages: Interacts with MASP1 and MASP2 (By similarity). Forms oligomeric complexes of 3, 4, 5 or, predominantly, 6 homotrimers. The homotrimers appear as globular heads that are connected to a central hub by thin stalks.
messages: O-glycosylated. O-linked glycans on hydroxylysine residues consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
messages: Secreted
messages: The helical collagen-like domains from three protein chains assemble into a coiled coil and mediate trimerization.

9823:SIN3B
gene id: 9823:SIN3B
uniprot id: A0A4X1UWF1
uniprot id: F1S9U7
names: Subcellular Location Annotation
messages: Nucleus

9823:SERPINC1
gene id: 9823:SERPINC1
uniprot id: A0A8D1FBQ8
uniprot id: Q19AZ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

9823:LOC100626599
gene id: 9823:LOC100626599
uniprot id: A0A5G2QYK1
uniprot id: A0A8D1EA98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ATF7
gene id: 9823:ATF7
uniprot id: A0A480XI33
uniprot id: A0A4X1WC38
uniprot id: A0A8D1XTI7
uniprot id: A0A8D1XZE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9823:CTNNA1
gene id: 9823:CTNNA1
uniprot id: A0A8D0WJJ4
uniprot id: A0A8D1G1G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9823:SLC18A2
gene id: 9823:SLC18A2
uniprot id: A0A4X1SWN0
uniprot id: A0A8D1D6Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Membrane
messages: secretory vesicle membrane
messages: synaptic vesicle membrane

9823:LOC100512174
gene id: 9823:LOC100512174
uniprot id: A5A8X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9823:ZDHHC6
gene id: 9823:ZDHHC6
uniprot id: A0A4X1T871
uniprot id: A0A8D0J036
uniprot id: A0A8D1M9P0
uniprot id: F1S5J9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:SUPV3L1
gene id: 9823:SUPV3L1
uniprot id: A0A480TMV4
uniprot id: A0A4X1TIG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9823:NUCB1
gene id: 9823:NUCB1
uniprot id: A0A4X1W1D7
uniprot id: A0A8D0ZWE7
names: Similarity
messages: Belongs to the nucleobindin family.

9823:C18H7orf25
gene id: 9823:C18H7orf25
uniprot id: F1SSE3
names: Similarity
messages: Belongs to the UPF0415 family.

9823:CRYBB2
gene id: 9823:CRYBB2
uniprot id: A0A8D0N8A0
uniprot id: F1RG87
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9823:MRPL58
gene id: 9823:MRPL58
uniprot id: A0A286ZJR2
uniprot id: A0A4X1V0P7
names: Subcellular Location Annotation
messages: Mitochondrion

9823:PSEN1
gene id: 9823:PSEN1
uniprot id: A0A4X1TMQ9
uniprot id: F1S3K9
uniprot id: Q0MS44
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

9823:MTAP
gene id: 9823:MTAP
uniprot id: A0A8D0Y5V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9823:NPY
gene id: 9823:NPY
uniprot id: A0A4X1U5L6
uniprot id: H2DHJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9823:MMD
gene id: 9823:MMD
uniprot id: A0A4X1V9I0
uniprot id: A0A8D1B7R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:ATAD1
gene id: 9823:ATAD1
uniprot id: A0A4X1V6Z6
uniprot id: A0A8D0UX60
names: Similarity
messages: Belongs to the AAA ATPase family.

9823:LOC100739741
gene id: 9823:LOC100739741
uniprot id: A0A0H4J4A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane
messages: Microsome membrane

9823:TUBB
gene id: 9823:TUBB
uniprot id: A0A480TK33
uniprot id: Q767L7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Heterodimer of alpha and beta chains (PubMed:7225365). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with CIMAP3. Interacts with DIAPH1 (By similarity). Interacts with MX1 (By similarity). May interact with RNABP10 (By similarity). Interacts with CFAP157 (By similarity). Nascent tubulin polypeptide interacts (via beta-tubulin MREI motif) with TTC5/STRAP; this interaction results in tubulin mRNA-targeted degradation (By similarity).
messages: Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:7225365). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:7225365). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:7225365).
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9823:UFC1
gene id: 9823:UFC1
uniprot id: A0A4X1VSC7
uniprot id: A0A8D1XUJ9
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9823:KLHL15
gene id: 9823:KLHL15
uniprot id: A0A8D1HS75
uniprot id: A0A8D1Q3V7
names: Subcellular Location Annotation
messages: Nucleus

9823:CFI
gene id: 9823:CFI
uniprot id: A0A287AQ20
uniprot id: A0A8D0K381
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:SPECC1L
gene id: 9823:SPECC1L
uniprot id: A0A4X1V4F2
uniprot id: A0A8D1F8K6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9823:NCK1
gene id: 9823:NCK1
uniprot id: B6E313
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9823:MRPL11
gene id: 9823:MRPL11
uniprot id: A0A480KRD0
uniprot id: A0A4X1TLX4
uniprot id: A0A4X1TRY9
uniprot id: F1RU54
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9823:USP2
gene id: 9823:USP2
uniprot id: A0A4X1SDS1
uniprot id: A0A4X1SDZ6
uniprot id: F1SAF6
uniprot id: I3LI16
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:NR1I2
gene id: 9823:NR1I2
uniprot id: A0A288CG31
uniprot id: A0A4X1T3P8
uniprot id: A0A4X1T4L7
uniprot id: Q2V0W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9823:ACHE
gene id: 9823:ACHE
uniprot id: A0A8D0LJY4
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9823:SHQ1
gene id: 9823:SHQ1
uniprot id: A0A4X1V8R1
uniprot id: F1SFN0
names: Similarity
messages: Belongs to the SHQ1 family.

9823:KIF5C
gene id: 9823:KIF5C
uniprot id: A0A480PZV2
uniprot id: A0A4X1THT2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:C6H19orf54
gene id: 9823:C6H19orf54
uniprot id: A0A286ZWY2
uniprot id: A0A4X1SPP7
names: Similarity
messages: Belongs to the ACTMAP family.

9823:POMGNT2
gene id: 9823:POMGNT2
uniprot id: A0A4X1TGU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:NDUFAB1
gene id: 9823:NDUFAB1
uniprot id: A0A4X1V0C8
uniprot id: A0A8D1KH26
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9823:SPCS1
gene id: 9823:SPCS1
uniprot id: A0A481DH50
uniprot id: B0FWK4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS1 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity).
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3. Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3. Within the complex, interacts with SPCS2 and SPCS3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Endoplasmic reticulum membrane
messages: May be phosphorylated.
messages: Membrane

9823:TFAP2B
gene id: 9823:TFAP2B
uniprot id: A0A287A582
uniprot id: A0A4X1UZ81
names: Similarity
messages: Belongs to the AP-2 family.

9823:CASP10
gene id: 9823:CASP10
uniprot id: C1PIJ2
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:SDAD1
gene id: 9823:SDAD1
uniprot id: A0A4X1SY54
uniprot id: F1RYU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9823:LMNB2
gene id: 9823:LMNB2
uniprot id: A0A286ZTL8
uniprot id: A0A4X1VTJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9823:KIF1BP
gene id: 9823:KIF1BP
uniprot id: A0A4X1TLJ5
uniprot id: A0A8D0IL06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

9823:CFAP126
gene id: 9823:CFAP126
uniprot id: A0A480EN68
uniprot id: A0A8D1L7G5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9823:LOC100514252
gene id: 9823:LOC100514252
uniprot id: F1SK76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100514307
gene id: 9823:LOC100514307
uniprot id: A0A8D0SUE5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CD81
gene id: 9823:CD81
uniprot id: Q007T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:FOLH1B
gene id: 9823:FOLH1B
uniprot id: O77564
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Binds 2 Zn(2+) ions per subunit. Required for NAALADase activity.
messages: Cell membrane
messages: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate.
messages: High expression in the duodenum and in the jejunum brush-border membrane. Weak expression in kidney.
messages: Homodimer.
messages: The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.
messages: The NAALADase activity is inhibited by quisqualic acid, beta-NAAG and 2-(phosphonomethyl) pentanedioic acid (PMPA). Ethanol ingestion decreases the folate hydrolase activity by 50%.

9823:DDX58
gene id: 9823:DDX58
uniprot id: B9WZD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9823:AGAP3
gene id: 9823:AGAP3
uniprot id: A0A480M665
uniprot id: A0A480U643
uniprot id: A0A8D1BYJ1
uniprot id: A0A8D1W0E8
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9823:CRK
gene id: 9823:CRK
uniprot id: B6DX82
names: Similarity
messages: Belongs to the CRK family.

9823:EIF2B2
gene id: 9823:EIF2B2
uniprot id: A0A4X1TA05
uniprot id: A0A8D1F8U4
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9823:INSL3
gene id: 9823:INSL3
uniprot id: P51461
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Expressed exclusively in prenatal and postnatal Leydig cells.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).

9823:B3GALT6
gene id: 9823:B3GALT6
uniprot id: A0A4X1W8M6
uniprot id: I3LU42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:SGCZ
gene id: 9823:SGCZ
uniprot id: B8YDG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9823:ARRDC3
gene id: 9823:ARRDC3
uniprot id: A0A480YTQ3
uniprot id: A0A8D0IAT3
names: Similarity
messages: Belongs to the arrestin family.

9823:ZNF280C
gene id: 9823:ZNF280C
uniprot id: A0A287B4J6
uniprot id: A0A8D0TCN6
uniprot id: A0A8D0VVX1
uniprot id: A0A8D1EGC8
uniprot id: A0A8D1PHA7
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9823:IP6K3
gene id: 9823:IP6K3
uniprot id: A0A286ZTI7
uniprot id: A0A8D0Y8D4
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9823:LOC100524479
gene id: 9823:LOC100524479
uniprot id: A0A4X1VN36
uniprot id: A0A8W4FLH9
names: Similarity
messages: Belongs to the peptidase A1 family.

9823:HOXD3
gene id: 9823:HOXD3
uniprot id: A0A8D0N1W4
uniprot id: F1RZF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:PNLDC1
gene id: 9823:PNLDC1
uniprot id: A0A4X1VVB4
uniprot id: F1SB65
names: Similarity
messages: Belongs to the CAF1 family.

9823:USP39
gene id: 9823:USP39
uniprot id: A0A4X1W038
uniprot id: A0A8D1INP8
names: Subcellular Location Annotation
messages: Nucleus

9823:CCBE1
gene id: 9823:CCBE1
uniprot id: A0A5G2R6U5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100516628
gene id: 9823:LOC100516628
uniprot id: A0A480QK70
uniprot id: A0A8D0NIX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9823:TMEM201
gene id: 9823:TMEM201
uniprot id: A0A286ZM85
uniprot id: A0A4X1W8F3
uniprot id: A0A4X1W9Q6
uniprot id: F1RIH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: Membrane
messages: Nucleus inner membrane

9823:APITD1
gene id: 9823:APITD1
uniprot id: A0A8D0WPN4
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

9823:PNMT
gene id: 9823:PNMT
uniprot id: Q06AU9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
messages: Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor. Other substrates include phenylethanolamine, octopamine and normetanephrine (By similarity).

9823:NAXE
gene id: 9823:NAXE
uniprot id: Q0PIT9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity).
messages: Homodimer (By similarity). Interacts with APOA1 and APOA2 (By similarity).
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

9823:TAAR2
gene id: 9823:TAAR2
uniprot id: A0A8D0ZHK5
uniprot id: F1S3Q5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:CHST7
gene id: 9823:CHST7
uniprot id: A0A480YBV2
uniprot id: A0A4X1SJU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9823:MCUR1
gene id: 9823:MCUR1
uniprot id: A0A8D0X2Z0
uniprot id: A0A8D1E4U6
uniprot id: F1RV76
names: Similarity
messages: Belongs to the CCDC90 family.

9823:KPNB1
gene id: 9823:KPNB1
uniprot id: A0A8D0ZHD7
uniprot id: F1RWJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

9823:ANGPTL4
gene id: 9823:ANGPTL4
uniprot id: Q2TNK5
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain; both cleaved and uncleaved forms are detected in the extracellular space. The cleaved form is not present within the cell.
messages: Forms disulfide-linked dimers and tetramers.
messages: Homooligomer; disulfide-linked via Cys residues in the N-terminal part of the protein (By similarity). The homooligomer undergoes proteolytic processing to release the ANGPTL4 C-terminal chain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix (By similarity).
messages: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (By similarity).
messages: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein.
messages: N-glycosylated.
messages: Secreted
messages: extracellular matrix

9823:TMED9
gene id: 9823:TMED9
uniprot id: A0A8D1JG30
uniprot id: F1S3E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:SLC6A7
gene id: 9823:SLC6A7
uniprot id: A0A480NQW3
uniprot id: A0A8D1JWC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9823:FAM110D
gene id: 9823:FAM110D
uniprot id: A0A287BIE5
uniprot id: A0A4X1VQ29
names: Similarity
messages: Belongs to the FAM110 family.

9823:ARL2BP
gene id: 9823:ARL2BP
uniprot id: A0A4X1SDE4
uniprot id: A0A8D0JZ04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9823:EPO
gene id: 9823:EPO
uniprot id: P49157
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
messages: Secreted

9823:LOC100522404
gene id: 9823:LOC100522404
uniprot id: A0A287AAM2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9823:SLC34A2
gene id: 9823:SLC34A2
uniprot id: H2EJJ3
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9823:GATA3
gene id: 9823:GATA3
uniprot id: Q0ZHH4
names: Subcellular Location Annotation
messages: Nucleus

9823:TMEM218
gene id: 9823:TMEM218
uniprot id: A0A4X1VJ85
uniprot id: A0A8W4FI54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9823:SPI1
gene id: 9823:SPI1
uniprot id: A0A8D1CP84
uniprot id: A0A8D1GAS7
uniprot id: Q6PKU1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETS family.
messages: Binds DNA as a monomer. Can form homomers (By similarity). Directly interacts with CEBPD/NF-IL6-beta; this interaction does not affect DNA-binding properties of each partner. Interacts with NONO/p54(nrb) (By similarity). Interacts with RUNX1/AML1. Interacts with GFI1; the interaction represses SPI1 transcriptional activity, hence blocks SPI1-induced macrophage differentiation of myeloid progenitor cells. Interacts with CEBPE. Interacts with IRF4/Pip and IRF8. Interacts with JUN. Interacts with RB1. Interacts with TBP (By similarity).
messages: Nucleus
messages: Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (By similarity). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition. Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (By similarity). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity).
messages: Transcriptional activity at macrophage-specific genes is inhibited by interaction with GFI1, which results in the inhibition of SPI1-induced macrophage differentiation of myeloid progenitor cells, but not that of the granulocyte lineage.

9823:TAS2R7
gene id: 9823:TAS2R7
uniprot id: A0A286ZVQ9
uniprot id: A0A8D0QG95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9823:ITM2B
gene id: 9823:ITM2B
uniprot id: A0A480V4R2
uniprot id: Q52N47
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITM2 family.
messages: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.
messages: Cell membrane
messages: Endosome membrane
messages: Glycosylation at Asn-170 is important for cell surface localization, but doesn't affect furin- and ADAM10-induced proteolytic processing.
messages: Golgi apparatus membrane
messages: Homodimer; disulfide-linked. Interacts with SPPL2A and SPPL2B. Interacts with APP. Mature BRI2 (mBRI2) interacts with the APP amyloid-beta A4 protein; the interaction occurs at the cell surface and in the endocytic compartments and enable alpha- and beta-secretase-induced APP cleavage inhibition. Mature BRI2 (mBRI2) interacts with the APP C99; the interaction occurs in the endocytic compartments and enable gamma-secretase-induced C99 cleavage inhibition. May form heterodimers with Bri23 peptide and APP amyloid-beta protein 40 (By similarity). Interacts with ADAM7 in sperm; the interaction increases following capacitation (By similarity).
messages: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.
messages: Membrane
messages: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity).
messages: Secreted
messages: The ectodomain C-terminal part of the imBRI2 is processed by furin producing a secreted Bri23 peptide and a mature BRI2, membrane form (mBRI2). The remaining part of the ectodomain of mBRI2 containing the BRICHOS domain is cleaved by ADAM10 and is secreted (BRI2C, soluble form). The membrane-bound N-terminal fragment (BRI2C, membrane form) is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted C-peptide and a BRI2 intracellular domain (BRI2 ICD) released in the cytosol. Shedding by ADAM10 facilitates intramembrane cleavage but is not absolutely required for BRI2 ICD generation (By similarity).

9823:FN1
gene id: 9823:FN1
uniprot id: A0A8D1VDG8
names: Function
messages: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling.

9823:LTB4R
gene id: 9823:LTB4R
uniprot id: A0A4X1SRI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9823:LOC100525483
gene id: 9823:LOC100525483
uniprot id: F1SDC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

9823:SLC25A3
gene id: 9823:SLC25A3
uniprot id: A0A8D1UBF5
uniprot id: C8C420
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9823:AGTR2
gene id: 9823:AGTR2
uniprot id: A0A4X1W622
uniprot id: A0A8D0LRX2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

9823:FDFT1
gene id: 9823:FDFT1
uniprot id: A0A480V551
uniprot id: A0A8D1KZC4
uniprot id: D0G6X3
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9823:TMEM50A
gene id: 9823:TMEM50A
uniprot id: A0A4X1VPG5
uniprot id: A0A8D1CAF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9823:ZPBP2
gene id: 9823:ZPBP2
uniprot id: A0A8D0WSY1
uniprot id: C8C4M8
uniprot id: C8C4M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted
messages: acrosome

9823:MORF4L2
gene id: 9823:MORF4L2
uniprot id: A0A8D1JPI9
uniprot id: K7GMX2
names: Subcellular Location Annotation
messages: Nucleus

9823:PLCD4
gene id: 9823:PLCD4
uniprot id: Q8SPR7
names: Cofactor
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 5 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity).
messages: Interacts with GRIP1 (By similarity). Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunit GNAI3 (inactive GDP-bound form); low-affinity interaction (By similarity).
messages: Membrane
messages: Nucleus
messages: The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.
messages: The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins).
messages: The PDZ-binding motif mediates the interaction with GRIP1.
messages: The PH domain is not a critical determinant of the membrane localization.

9823:PFDN2
gene id: 9823:PFDN2
uniprot id: A0A8D1XU91
uniprot id: F1S192
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9823:LOC100521256
gene id: 9823:LOC100521256
uniprot id: A0A8D0SJ25
uniprot id: A0A8D0UVF9
uniprot id: F1RGD8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9823:RPS10
gene id: 9823:RPS10
uniprot id: A0A8D1CRI2
uniprot id: A0A8D1JJG2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9823:MAB21L3
gene id: 9823:MAB21L3
uniprot id: A0A8D0IHT2
names: Similarity
messages: Belongs to the mab-21 family.

9823:PCCB
gene id: 9823:PCCB
uniprot id: P79384
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AccD/PCCB family.
messages: Mitochondrion matrix
messages: The beta subunit contains the carboxyl transferase (CT) domain.
messages: The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.
messages: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:13752080). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:13752080). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:13752080). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (PubMed:13752080).

9823:LOC100738056
gene id: 9823:LOC100738056
uniprot id: A0A8D0NPF1
uniprot id: A0A8D0VK27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9823:LOC100525350
gene id: 9823:LOC100525350
uniprot id: A0A4X1U7A2
uniprot id: A0A4X1U7A7
uniprot id: F1RWF0
uniprot id: I3L709
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

9823:KCNE1
gene id: 9823:KCNE1
uniprot id: A0A4X1TV48
uniprot id: A0A8D1LKU9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the potassium channel KCNE family.
messages: Cell membrane
messages: Membrane

9823:PGBD1
gene id: 9823:PGBD1
uniprot id: A0A8D0I2W0
uniprot id: F1S1R8
names: Subcellular Location Annotation
messages: Nucleus

9823:CYB5A
gene id: 9823:CYB5A
uniprot id: P00172
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family.
messages: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9823:SERPINI1
gene id: 9823:SERPINI1
uniprot id: A0A8D1GMY7
uniprot id: F1SH33
names: Similarity
messages: Belongs to the serpin family.

9823:CHGB
gene id: 9823:CHGB
uniprot id: A0A8D0PIS6
uniprot id: Q6IYD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9823:PSMD9
gene id: 9823:PSMD9
uniprot id: A0A286ZLP7
uniprot id: A0A4X1UAE8
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9823:TOLLIP
gene id: 9823:TOLLIP
uniprot id: A0A4X1UEU5
uniprot id: G9M4N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9823:SLC2A12
gene id: 9823:SLC2A12
uniprot id: A0A287BJ50
uniprot id: A0A480R5U9
uniprot id: A0A8D0LZX9
uniprot id: A0A8D0M0A8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9823:UTP14A
gene id: 9823:UTP14A
uniprot id: F1RTH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

9823:CCDC130
gene id: 9823:CCDC130
uniprot id: A0A8D0UTV6
names: Similarity
messages: Belongs to the CWC16 family.

9823:PRL
gene id: 9823:PRL
uniprot id: P01238
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the somatotropin/prolactin family.
messages: Interacts with PRLR.
messages: Prolactin acts primarily on the mammary gland by promoting lactation.
messages: Secreted

9823:KCNJ3
gene id: 9823:KCNJ3
uniprot id: A0A4X1VSE2
uniprot id: A0A8D0YGR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

9823:CTSC
gene id: 9823:CTSC
uniprot id: A0A4X1U3C8
uniprot id: A0A8D1G0R0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9823:KCNK7
gene id: 9823:KCNK7
uniprot id: F1RRI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9823:RAD18
gene id: 9823:RAD18
uniprot id: A0A8D1LSG5
uniprot id: B7TJ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9823:LOC100513450
gene id: 9823:LOC100513450
uniprot id: A0A4X1VL85
uniprot id: A0A4X1VL90
names: Similarity
messages: Belongs to the GAGE family.

9823:HOXB6
gene id: 9823:HOXB6
uniprot id: A0A4X1UPD6
uniprot id: F1RWG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:FOXK2
gene id: 9823:FOXK2
uniprot id: A0A8D2BVT5
names: Subcellular Location Annotation
messages: Nucleus

9823:HCRTR1
gene id: 9823:HCRTR1
uniprot id: O97661
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
messages: The N-terminal region is required for orexin signaling.

9823:PLIN3
gene id: 9823:PLIN3
uniprot id: Q5BLZ2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the perilipin family.
messages: Cytoplasm
messages: Endosome membrane
messages: Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain).
messages: Lipid droplet
messages: Phosphorylation at Tyr-256 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.
messages: Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.

9823:LOC100157689
gene id: 9823:LOC100157689
uniprot id: A0A5G2QWK8
uniprot id: A0A8D1R5L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PCYOX1
gene id: 9823:PCYOX1
uniprot id: A0A8D1RI20
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9823:FAM53B
gene id: 9823:FAM53B
uniprot id: A0A480VS16
uniprot id: A0A4X1VAV3
names: Similarity
messages: Belongs to the FAM53 family.

9823:LOC106504121
gene id: 9823:LOC106504121
uniprot id: A0A4X1VKV5
uniprot id: F1RVA0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:B3GNT5
gene id: 9823:B3GNT5
uniprot id: Q864U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
messages: Golgi apparatus membrane

9823:SMPDL3A
gene id: 9823:SMPDL3A
uniprot id: A0A8D1EWD0
uniprot id: F1S2T7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9823:CTSW
gene id: 9823:CTSW
uniprot id: A0A8D1IGI7
uniprot id: F1RU23
names: Similarity
messages: Belongs to the peptidase C1 family.

9823:B3GAT1
gene id: 9823:B3GAT1
uniprot id: A0A286ZTI9
uniprot id: A0A8D1MS48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:PTGER2
gene id: 9823:PTGER2
uniprot id: A0A4X1WDD2
uniprot id: F1SFF0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:TMEM184A
gene id: 9823:TMEM184A
uniprot id: A0A8D1GUB8
uniprot id: A0A8D1YBD8
uniprot id: F1RIV1
names: Subcellular Location Annotation
messages: Membrane

9823:SLC39A1
gene id: 9823:SLC39A1
uniprot id: A0A8D0IDA8
uniprot id: F1RFX1
names: Subcellular Location Annotation
messages: Membrane

9823:MAL
gene id: 9823:MAL
uniprot id: A0A4X1VVL7
uniprot id: A0A5G2RFS7
names: Subcellular Location Annotation
messages: Membrane

9823:VLDLR
gene id: 9823:VLDLR
uniprot id: A0A481B6P9
uniprot id: A0A4X1W8P4
uniprot id: A0A8D1YMR3
uniprot id: E7CXS1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:THAP1
gene id: 9823:THAP1
uniprot id: A0A287AAN9
uniprot id: A0A8D0NGG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9823:PPM1G
gene id: 9823:PPM1G
uniprot id: A0A287BJ42
uniprot id: A0A4X1TLS0
names: Similarity
messages: Belongs to the PP2C family.

9823:PET117
gene id: 9823:PET117
uniprot id: A0A8W4FKS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

9823:APIP
gene id: 9823:APIP
uniprot id: A0A4X1SQ75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9823:THTPA
gene id: 9823:THTPA
uniprot id: A0A4X1SIS7
uniprot id: F1SS41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9823:FAM110A
gene id: 9823:FAM110A
uniprot id: A0A8D1VQT7
uniprot id: F1S865
names: Similarity
messages: Belongs to the FAM110 family.

9823:CES3
gene id: 9823:CES3
uniprot id: A0A4X1URB8
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9823:STC1
gene id: 9823:STC1
uniprot id: A0A8D1LML8
uniprot id: A7XNM3
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9823:APLN
gene id: 9823:APLN
uniprot id: A0A4X1W9W6
uniprot id: A0A5G2R3Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apelin family.
messages: extracellular space

9823:INTS10
gene id: 9823:INTS10
uniprot id: A0A480KC81
uniprot id: A0A480KGS2
uniprot id: A0A4X1UBF9
uniprot id: A0A4X1UD89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9823:PTGIR
gene id: 9823:PTGIR
uniprot id: A0A4X1W284
uniprot id: I3LT62
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:CTNNAL1
gene id: 9823:CTNNAL1
uniprot id: A0A4X1VC34
uniprot id: F1SP25
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9823:CNTFR
gene id: 9823:CNTFR
uniprot id: A0A480KAN0
uniprot id: A0A4X1UV22
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9823:LUC7L
gene id: 9823:LUC7L
uniprot id: A0A4X1UIT7
uniprot id: A0A8D0SWN6
uniprot id: A0A8D1PPU7
names: Similarity
messages: Belongs to the Luc7 family.

9823:CLCN2
gene id: 9823:CLCN2
uniprot id: A0A480UNX6
uniprot id: A0A8D1E7M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

9823:ODC1
gene id: 9823:ODC1
uniprot id: A0A4X1UED3
uniprot id: B2CPJ8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9823:MRTO4
gene id: 9823:MRTO4
uniprot id: A0A480VYI2
uniprot id: A0A8D1HAQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9823:DLL4
gene id: 9823:DLL4
uniprot id: A0A4X1URL1
uniprot id: A0A8D1MP84
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9823:DBI
gene id: 9823:DBI
uniprot id: P12026
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ACBP family.
messages: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
messages: DBI(32-86) has antibacterial properties.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Monomer.

9823:GAP43
gene id: 9823:GAP43
uniprot id: A0A287A0Z5
uniprot id: A0A4X1T113
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9823:GRPEL1
gene id: 9823:GRPEL1
uniprot id: A0A8D0PZ52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9823:KMO
gene id: 9823:KMO
uniprot id: A0A8D1IRP1
uniprot id: I3LAL5
uniprot id: Q9MZS9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
messages: Mitochondrion outer membrane
messages: Transmembrane domains are required for enzymatic activity.

9823:MS4A7
gene id: 9823:MS4A7
uniprot id: A0A4X1VMK5
uniprot id: A0A8D0NPT1
names: Similarity
messages: Belongs to the MS4A family.

9823:LOC100515126
gene id: 9823:LOC100515126
uniprot id: A0A287AQF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SUGP2
gene id: 9823:SUGP2
uniprot id: A0A287AX25
uniprot id: A0A4X1U3V1
names: Subcellular Location Annotation
messages: Nucleus

9823:GPX2
gene id: 9823:GPX2
uniprot id: Q09HS4
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9823:GPC4
gene id: 9823:GPC4
uniprot id: A0A4X1WA83
uniprot id: F1RTE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9823:AFF4
gene id: 9823:AFF4
uniprot id: A0A8D0PCP4
uniprot id: I3L7N2
names: Similarity
messages: Belongs to the AF4 family.

9823:CYP7A1
gene id: 9823:CYP7A1
uniprot id: A0A8D2C6S8
uniprot id: F1RT71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9823:H2AFZ
gene id: 9823:H2AFZ
uniprot id: A0A8D1FVF0
uniprot id: B1PEY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:NDUFS6
gene id: 9823:NDUFS6
uniprot id: A0A4X1THU2
uniprot id: F1S031
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mitochondrion inner membrane

9823:OPN4
gene id: 9823:OPN4
uniprot id: A0A8D1E3Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9823:LOC100738522
gene id: 9823:LOC100738522
uniprot id: A0A287AT12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ACE
gene id: 9823:ACE
uniprot id: A0A480IQM9
uniprot id: A0A8D1QGW8
uniprot id: A0A8D1QK76
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.

9823:CD244
gene id: 9823:CD244
uniprot id: A0A8D1U949
uniprot id: F1S174
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100620388
gene id: 9823:LOC100620388
uniprot id: I3LTY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GNG12
gene id: 9823:GNG12
uniprot id: A0A4X1U1S2
uniprot id: B9TRW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9823:LOC100523167
gene id: 9823:LOC100523167
uniprot id: A0A5G2QSG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NPPB
gene id: 9823:NPPB
uniprot id: P07634
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the natriuretic peptide family.
messages: Brain (at protein level).
messages: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3 (By similarity).
messages: Heart atrium.
messages: May affect cardio-renal homeostasis. Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32.
messages: Plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed:2964562). In vivo, induces vasodilation (PubMed:2964562).
messages: Secreted
messages: The precursor molecule is proteolytically cleaved by the endoproteases FURIN or CORIN at Arg-99 to produce the active brain natriuretic peptide 32 and the inactive NT-proBNP. CORIN also cleaves the precursor molecule at additional residues including Arg-96 and possibly Lys-102 (By similarity). Undergoes further proteolytic cleavage by unknown proteases to give rise to Brain natriuretic peptide 26 (PubMed:3421965).
messages: Undergoes further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides. Cleaved at Pro-101 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Degraded by IDE. During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro).

9823:LBX1
gene id: 9823:LBX1
uniprot id: A0A4X1U2J8
uniprot id: D7R811
names: Subcellular Location Annotation
messages: Nucleus

9823:MRPS26
gene id: 9823:MRPS26
uniprot id: A0A4X1SEN9
uniprot id: F1S8A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9823:DPPA2
gene id: 9823:DPPA2
uniprot id: A0A4X1T959
uniprot id: A0A8D0HY71
names: Subcellular Location Annotation
messages: Nucleus

9823:SLC30A3
gene id: 9823:SLC30A3
uniprot id: A0A4X1TL95
uniprot id: B6VAW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9823:RAB9A
gene id: 9823:RAB9A
uniprot id: A0A8D0XQ01
uniprot id: F1SRI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9823:CXCL10
gene id: 9823:CXCL10
uniprot id: A0A8D1BK15
uniprot id: Q5S1S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9823:RMI1
gene id: 9823:RMI1
uniprot id: A0A8D1XHI9
uniprot id: F1S4G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9823:ISG20
gene id: 9823:ISG20
uniprot id: Q66UW5
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with PML and SP100 in the PML NB complex. Associates with survival motor neuron protein (SMN)-containing macromolecular nuclear complexes and U1 and U2 snRNAs and U3 snoRNA (By similarity).
messages: Belongs to the exonuclease superfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cajal body
messages: Cytoplasm
messages: Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression was seen at the transcriptional level (By similarity).
messages: Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA. Inhibition of several viruses does not involve the degradation of viral RNAs, but rather the inhibition of translation of viral proteins. Exerts a translational control over a large panel of non-self RNA substrates while sparing endogenous transcripts. This activity correlates with the protein's ability to localize in cytoplasmic processing bodies. May also act as master regulator of over hundred interferon stimulated genes leading to viral genome translation inhibition (By similarity). May play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (By similarity).
messages: Nucleus
messages: nucleolus

9823:FZD4
gene id: 9823:FZD4
uniprot id: A0A480XCK5
uniprot id: A0A4X1U400
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

9823:SUDS3
gene id: 9823:SUDS3
uniprot id: A0A8D1G881
uniprot id: F1RKH0
names: Subcellular Location Annotation
messages: Nucleus

9823:EIPR1
gene id: 9823:EIPR1
uniprot id: A0A480LI92
uniprot id: A0A8D1NZ97
uniprot id: A0A8D1TRG7
uniprot id: I3LHX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EIPR1 family.
messages: trans-Golgi network

9823:HEBP1
gene id: 9823:HEBP1
uniprot id: Q5ISC6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEBP family.
messages: Cytoplasm
messages: Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
messages: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity).
messages: Monomer.

9823:LOC100521607
gene id: 9823:LOC100521607
uniprot id: A0A4X1TVG1
uniprot id: A0A8D1PA11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SSR3
gene id: 9823:SSR3
uniprot id: A0A8D1G1A7
uniprot id: I3LGD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9823:FAM173A
gene id: 9823:FAM173A
uniprot id: A0A4X1SVX7
uniprot id: F1RG48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

9823:ADAM3A
gene id: 9823:ADAM3A
uniprot id: A5A4F6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:IFN-DELTA-4
gene id: 9823:IFN-DELTA-4
uniprot id: C8CKB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:ATAT1
gene id: 9823:ATAT1
uniprot id: A0A4X1VJE9
uniprot id: A0A5G2R9W6
uniprot id: A0A8D0IG44
uniprot id: A0A8D1JD14
uniprot id: I3L925
uniprot id: Q767K7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

9823:CYGB
gene id: 9823:CYGB
uniprot id: A0A4X1UXM8
names: Similarity
messages: Belongs to the globin family.

9823:MC2R
gene id: 9823:MC2R
uniprot id: Q8HYN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in skin and adrenal gland tissues.
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH) (By similarity).
messages: Receptor for corticotropin (ACTH). This receptor is mediated by G proteins which activate adenylate cyclase (cAMP).

9823:EYA4
gene id: 9823:EYA4
uniprot id: A0A287AST8
uniprot id: A0A480SJS2
uniprot id: A0A4X1V744
uniprot id: A0A4X1VAD9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9823:GLRA3
gene id: 9823:GLRA3
uniprot id: A0A287ABX9
uniprot id: A0A4X1V717
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9823:LOC100513844
gene id: 9823:LOC100513844
uniprot id: A0A4X1VRP1
uniprot id: F1SBU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9823:SYN1
gene id: 9823:SYN1
uniprot id: A0A4X1T9Y1
uniprot id: A0A8D2ABL6
uniprot id: B7TY10
uniprot id: B7TY11
names: Similarity
messages: Belongs to the synapsin family.

9823:VBP1
gene id: 9823:VBP1
uniprot id: A0A4X1T8E4
uniprot id: A0A8D1GN55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9823:IK
gene id: 9823:IK
uniprot id: A0A8D0IN63
uniprot id: A0A8W4FAS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9823:TMEM8A
gene id: 9823:TMEM8A
uniprot id: A0A8D0RDJ2
uniprot id: F1RGV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9823:ANXA9
gene id: 9823:ANXA9
uniprot id: A0A287AK76
uniprot id: A0A8D0SC59
uniprot id: A0A8D1ZM65
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9823:RB1
gene id: 9823:RB1
uniprot id: J7FNA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9823:TRPC1
gene id: 9823:TRPC1
uniprot id: A0A4X1T6N8
uniprot id: C0JJ14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9823:KLRK1
gene id: 9823:KLRK1
uniprot id: A0A286ZSM5
uniprot id: A0A4X1UZL1
uniprot id: Q9GLF5
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Detected in peripheral blood leukocytes, macrophages, monocytes and natural killer cells.
messages: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins (By similarity).
messages: Homodimer; disulfide-linked. Heterohexamer composed of two subunits of KLRK1 and four subunits of HCST/DAP10. Interacts (via transmembrane domain) with HCST/DAP10 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Can form disulfide-bonded heterodimer with CD94 (By similarity). Interacts with CEACAM1; recruits PTPN6 that dephosphorylates VAV1 (By similarity).
messages: Is not capable of signal transduction by itself, but operates through the adapter protein HCST.

9823:GALNT16
gene id: 9823:GALNT16
uniprot id: A0A8D0R7K7
uniprot id: A0A8D1F3L5
uniprot id: F1S4B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9823:PPP6R2
gene id: 9823:PPP6R2
uniprot id: A0A4X1ULZ7
uniprot id: F1RXT3
names: Similarity
messages: Belongs to the SAPS family.

9823:GNB2
gene id: 9823:GNB2
uniprot id: A0A4X1UES8
uniprot id: F2Z4Z8
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9823:LOC100523262
gene id: 9823:LOC100523262
uniprot id: A0A4X1TIK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GGACT
gene id: 9823:GGACT
uniprot id: A0A5G2QZR2
uniprot id: A0A8D0Y8Y3
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9823:CLDN9
gene id: 9823:CLDN9
uniprot id: C3VMK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:DFNB59
gene id: 9823:DFNB59
uniprot id: A0A480MQ05
uniprot id: A0A8D0TPW8
names: Similarity
messages: Belongs to the gasdermin family.

9823:S100A8
gene id: 9823:S100A8
uniprot id: A0A8D0TYA1
uniprot id: C3S7K5
names: Similarity
messages: Belongs to the S-100 family.

9823:FKBP4
gene id: 9823:FKBP4
uniprot id: A0A8D0NS09
uniprot id: D3K5K2
names: Subcellular Location Annotation
messages: Mitochondrion
messages: cytoskeleton
messages: cytosol

9823:GGT6
gene id: 9823:GGT6
uniprot id: A0A8D0WIB5
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

9823:SLC1A3
gene id: 9823:SLC1A3
uniprot id: A0A4X1TA36
uniprot id: A0A4X1TC18
uniprot id: A0A8D1AVR0
uniprot id: A0A8D1WMV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9823:TNFAIP1
gene id: 9823:TNFAIP1
uniprot id: A0A8D0K3X6
uniprot id: I3LM60
names: Similarity
messages: Belongs to the BACURD family.

9823:MRPL35
gene id: 9823:MRPL35
uniprot id: A0A4X1W4R3
uniprot id: A0A5G2QZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9823:MTMR3
gene id: 9823:MTMR3
uniprot id: A0A480EZA2
uniprot id: A0A480M004
uniprot id: A0A4X1VBR1
uniprot id: A0A4X1VBS3
uniprot id: A0A4X1VEF8
uniprot id: A0A4X1VEG8
uniprot id: A0A4X1VEJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9823:LOC100737113
gene id: 9823:LOC100737113
uniprot id: A0A287AK58
uniprot id: A0A8D0U4A9
names: Similarity
messages: Belongs to the intermediate filament family.

9823:NSRP1
gene id: 9823:NSRP1
uniprot id: A0A4X1U036
uniprot id: A0A8D0I1K1
names: Similarity
messages: Belongs to the NSRP1 family.

9823:NNMT
gene id: 9823:NNMT
uniprot id: Q06AV1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
messages: Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (By similarity). Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases (By similarity). Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3 (By similarity). In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (By similarity). Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis (By similarity). In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (By similarity).
messages: Cytoplasm
messages: Deiminated by PADI1 and PADI2.
messages: Monomer.

9823:CLDN15
gene id: 9823:CLDN15
uniprot id: A0A8D0YXD8
uniprot id: C3VMK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:PRKAB1
gene id: 9823:PRKAB1
uniprot id: A0A4X1TVD6
uniprot id: A0A8D1J554
uniprot id: A0A8D1LXQ5
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9823:DPP3
gene id: 9823:DPP3
uniprot id: A0A480T9G8
uniprot id: A0A5G2RLJ6
uniprot id: A0A8D0NGG9
uniprot id: F1RU52
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

9823:RPL7L1
gene id: 9823:RPL7L1
uniprot id: A0A480EJX3
uniprot id: A5GFQ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9823:LOC100627422
gene id: 9823:LOC100627422
uniprot id: A0A8D0TMC9
uniprot id: A0A8D1KSJ7
names: Subcellular Location Annotation
messages: Nucleus

9823:ACTC1
gene id: 9823:ACTC1
uniprot id: A0A8D0YZG3
uniprot id: B6VNT8
names: Similarity
messages: Belongs to the actin family.

9823:ARRDC2
gene id: 9823:ARRDC2
uniprot id: A0A287AMQ8
uniprot id: A0A4X1UBD4
uniprot id: A0A8D1RZJ8
uniprot id: F1S922
names: Similarity
messages: Belongs to the arrestin family.

9823:LOC110255212
gene id: 9823:LOC110255212
uniprot id: A0A287B1Z6
uniprot id: A0A8D1L7C0
names: Subcellular Location Annotation
messages: Nucleus

9823:CFL2
gene id: 9823:CFL2
uniprot id: B2CZR7
uniprot id: Q5G6V9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).
messages: Nucleus matrix
messages: The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
messages: cytoskeleton

9823:HAPLN3
gene id: 9823:HAPLN3
uniprot id: A0A4X1U6Q5
uniprot id: A0A4X1U6R5
uniprot id: A0A5G2R305
uniprot id: A0A8D0V1P7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:CREB5
gene id: 9823:CREB5
uniprot id: A0A4X1TIZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9823:AXL
gene id: 9823:AXL
uniprot id: A0A8D1XHU7
uniprot id: B2DD00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

9823:NTHL1
gene id: 9823:NTHL1
uniprot id: A0A8D0NBU5
uniprot id: A0A8D0WQZ7
uniprot id: A0A8W4FNR8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Interacts with YBX1.
messages: Mitochondrion
messages: Nucleus

9823:ATP6V1A
gene id: 9823:ATP6V1A
uniprot id: Q29048
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP hydrolysis occurs at the interface between the nucleotide-binding domains of subunits A and B (By similarity). ATP hydrolysis triggers a conformational change in the subunits D and F, which induces a shift of subunit d (By similarity). The c-ring is subsequently rotated and results in a continuous proton translocation across the membrane (By similarity).
messages: Belongs to the ATPase alpha/beta chains family.
messages: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in neurite development and synaptic connectivity (By similarity).
messages: Cytoplasm
messages: Lysosome
messages: Phosphorylation at Ser-384 by AMPK down-regulates its enzyme activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with the V0 complex V-ATPase subunit a4 ATP6V0A4 (By similarity). Interacts with WFS1 (By similarity). Interacts with alpha-crystallin B chain/CRYAB and with MTOR, forming a ternary complex (By similarity).
messages: clathrin-coated vesicle membrane
messages: cytosol
messages: secretory vesicle

9823:CSF2
gene id: 9823:CSF2
uniprot id: Q29118
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).
messages: Secreted

9823:QPRT
gene id: 9823:QPRT
uniprot id: I3LK75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

9823:MED9
gene id: 9823:MED9
uniprot id: A0A4X1SRM9
uniprot id: F1SB14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:ARAP2
gene id: 9823:ARAP2
uniprot id: A0A8D1QD97
uniprot id: F1S4M1
names: Subcellular Location Annotation
messages: Cytoplasm

9823:CHAT
gene id: 9823:CHAT
uniprot id: P13222
names: Function
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.

9823:CAPRIN1
gene id: 9823:CAPRIN1
uniprot id: A0A4X1SSD2
uniprot id: F1SGS6
names: Similarity
messages: Belongs to the caprin family.

9823:SLC30A1
gene id: 9823:SLC30A1
uniprot id: A0A4X1TIE8
uniprot id: B6VCB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9823:LOC100523626
gene id: 9823:LOC100523626
uniprot id: A0A4X1SNG8
uniprot id: A0A8D1PNR3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TMEM57
gene id: 9823:TMEM57
uniprot id: Q2TLZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the macoilin family.
messages: Nucleus membrane
messages: Plays a role in the regulation of neuronal activity.
messages: Rough endoplasmic reticulum membrane

9823:SIGLEC1
gene id: 9823:SIGLEC1
uniprot id: A7LCJ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Facilitates porcine reproductive and respiratory syndrome virus (PRRSV) infection via inhibition of type I IFN transcription.
messages: (Microbial infection) Interacts with porcine reproductive respiratory syndrome virus glycoprotein 5.
messages: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
messages: Cell membrane
messages: Interacts with TYROBP (PubMed:32093750). Interacts with CLEC10A (By similarity).
messages: Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response. Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs). In turn, enhances macrophage-to-T-cell transmission of several viruses including reproductive and respiratory syndrome virus or porcine arterivirus (PubMed:10073688, PubMed:17567703). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (By similarity).
messages: The sialic acid-binding domain is essential for efficient PRRSV virus attachment and internalization to alveolar macrophages.

9823:FAM83E
gene id: 9823:FAM83E
uniprot id: A0A4X1VUV2
uniprot id: I3LFA9
names: Similarity
messages: Belongs to the FAM83 family.

9823:PIGO
gene id: 9823:PIGO
uniprot id: A0A8D0P435
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:WASF2
gene id: 9823:WASF2
uniprot id: A0A5K1VSC0
uniprot id: A0A8D1L6Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9823:GJB1
gene id: 9823:GJB1
uniprot id: F1RSW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:SCARB1
gene id: 9823:SCARB1
uniprot id: A0A481C9Z2
uniprot id: Q8SQC1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: N-glycosylated.
messages: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
messages: The C-terminal region binds to PDZK1.
messages: The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
messages: caveola

9823:LOC100511653
gene id: 9823:LOC100511653
uniprot id: A0A4X1UNL0
uniprot id: A0A5G2QNV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GDF15
gene id: 9823:GDF15
uniprot id: A0A4X1U9F3
uniprot id: D3Y269
names: Similarity
messages: Belongs to the TGF-beta family.

9823:RPS17
gene id: 9823:RPS17
uniprot id: Q6QAP7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS17 family.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: Ubiquitinated at Lys-103 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).
messages: nucleolus

9823:DPYD
gene id: 9823:DPYD
uniprot id: Q28943
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 2 FAD.
messages: Binds 2 FMN.
messages: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Inactivated by 5-iodouracil.
messages: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

9823:SNRPD2
gene id: 9823:SNRPD2
uniprot id: A0A287BQU7
uniprot id: A0A8D0JL81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: cytosol

9823:PLAC8L1
gene id: 9823:PLAC8L1
uniprot id: A0A8D0S5I1
uniprot id: F1RM19
names: Similarity
messages: Belongs to the cornifelin family.

9823:CHPT1
gene id: 9823:CHPT1
uniprot id: A0A287B7T8
uniprot id: A0A8D1G3S1
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9823:S1PR3
gene id: 9823:S1PR3
uniprot id: A0A4X1SGB4
uniprot id: F1RN19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:CTC1
gene id: 9823:CTC1
uniprot id: A0A8D1RLP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9823:CLDN7
gene id: 9823:CLDN7
uniprot id: A0A8D1VE38
uniprot id: C3VPJ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:CRSP-2
gene id: 9823:CRSP-2
uniprot id: Q766Y7
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calcitonin family.
messages: Mainly expressed in the thyroid gland and CNS. Found in the nerve cells of the cerebrum, hippocampus, hypothalamus, pons/midbrain and thalamus. Also detected in the glia-like cells of pons/midbrain and in meninx of tactus opticus.
messages: Secreted

9823:MAML1
gene id: 9823:MAML1
uniprot id: A0A4X1VX41
uniprot id: F1S442
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

9823:ATP5D
gene id: 9823:ATP5D
uniprot id: A0A286ZYL7
uniprot id: A0A4X1VPE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrion inner membrane

9823:VAMP2
gene id: 9823:VAMP2
uniprot id: A0A4X1VAA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9823:SUCLG1
gene id: 9823:SUCLG1
uniprot id: O19069
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Isoform I is expressed in all tissues examined: liver, brain, heart, and skeletal muscle. Isoform II is expressed only in heart and skeletal muscle.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

9823:KPNA2
gene id: 9823:KPNA2
uniprot id: C6K7I0
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9823:ELOF1
gene id: 9823:ELOF1
uniprot id: A0A8D1B522
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9823:PTP4A1
gene id: 9823:PTP4A1
uniprot id: A0A8D0P2W9
uniprot id: K9IWI1
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9823:KIF18A
gene id: 9823:KIF18A
uniprot id: A0A8D0T2F9
uniprot id: F1SGM6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:KLHL3
gene id: 9823:KLHL3
uniprot id: A0A4X1V568
uniprot id: A0A8D1I9U7
uniprot id: A0A8D1IG49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KLHL3 family.
messages: cytoskeleton
messages: cytosol

9823:TP53RK
gene id: 9823:TP53RK
uniprot id: A0A4X1U5G0
uniprot id: F1SBF6
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

9823:AP1S2
gene id: 9823:AP1S2
uniprot id: A0A4X1UX87
uniprot id: A0A4X1UX92
uniprot id: A0A4X1UYB3
uniprot id: A0A8D0J5F4
uniprot id: A0A8D1K6F2
uniprot id: A0A8D1UV47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9823:NSDHL
gene id: 9823:NSDHL
uniprot id: A0A8D0QIB0
uniprot id: D0G782
uniprot id: F1S2D0
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9823:VHL
gene id: 9823:VHL
uniprot id: A0A480XG01
uniprot id: A0A4X1USI4
names: Similarity
messages: Belongs to the VHL family.

9823:AVPR2
gene id: 9823:AVPR2
uniprot id: A0A2C9F3C6
uniprot id: A0A8D1A7B3
uniprot id: P32307
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Interacts with ARRDC4 (By similarity). Identified in a complex containing at least ARRDC4, V2R and HGS (By similarity). Interacts with TMEM147 (By similarity).
messages: Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:8393786). Involved in renal water reabsorption (By similarity).

9823:NDUFS5
gene id: 9823:NDUFS5
uniprot id: A0A4X1VX77
uniprot id: F1SV23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9823:KEF22 p04
gene id: 9823:KEF22_p04
uniprot id: O79881
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9823:NAPB
gene id: 9823:NAPB
uniprot id: A0A480DU21
uniprot id: A0A4X1V0Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9823:TMCC3
gene id: 9823:TMCC3
uniprot id: A0A287A0Q7
uniprot id: A0A8D0U876
names: Similarity
messages: Belongs to the TEX28 family.

9823:CYP8B1
gene id: 9823:CYP8B1
uniprot id: Q7YRB2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis. Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis (PubMed:14643796). Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase) (By similarity).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in fetal liver, but absent in 4 days old and 6 weeks old unweaned pigs.
messages: Microsome membrane

9823:ALDH1B1
gene id: 9823:ALDH1B1
uniprot id: A0A8D1ZUR1
uniprot id: F1ST54
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9823:ATG9A
gene id: 9823:ATG9A
uniprot id: A0A480SYV2
uniprot id: A0A8D0P8I9
uniprot id: D7RA26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9823:MTERF3
gene id: 9823:MTERF3
uniprot id: A0A287BLV9
uniprot id: A0A4X1U2Q6
uniprot id: A0A4X1U2R5
uniprot id: F1RY61
names: Similarity
messages: Belongs to the mTERF family.

9823:KCNK10
gene id: 9823:KCNK10
uniprot id: A0A287AIG4
uniprot id: A0A287B930
uniprot id: A0A4X1SZF9
uniprot id: A0A4X1SZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9823:LOC100157720
gene id: 9823:LOC100157720
uniprot id: F1SP66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GAD2
gene id: 9823:GAD2
uniprot id: P48321
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the production of GABA.
messages: Cytoplasmic vesicle
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Palmitoylated; which is required for presynaptic clustering.
messages: Phosphorylated; which does not affect kinetic parameters or subcellular location.
messages: Presynaptic cell membrane
messages: cytosol

9823:LOC100625049
gene id: 9823:LOC100625049
uniprot id: A0A481CVE5
uniprot id: A0A4X1T1T9
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

9823:TACC3
gene id: 9823:TACC3
uniprot id: A0A4X1T1Q3
uniprot id: F1S8S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9823:PLK3
gene id: 9823:PLK3
uniprot id: A0A4X1W400
uniprot id: F1S348
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9823:SLC12A9
gene id: 9823:SLC12A9
uniprot id: A0A8D1XL87
uniprot id: I3LUK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9823:MRPL20
gene id: 9823:MRPL20
uniprot id: A0A286ZU56
uniprot id: A0A4X1W3A3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

9823:SEPT12
gene id: 9823:SEPT12
uniprot id: A0A4X1VLP5
uniprot id: F1RK75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9823:BACE1
gene id: 9823:BACE1
uniprot id: A0A8D0JXI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: trans-Golgi network

9823:LOC100521984
gene id: 9823:LOC100521984
uniprot id: A0A4X1TEG1
uniprot id: A0A5G2QHG3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC102167894
gene id: 9823:LOC102167894
uniprot id: A0A0G3VQE0
uniprot id: A0A8D0M6A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:ITIH4
gene id: 9823:ITIH4
uniprot id: P79263
names: Function
names: Induction
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Appears to be both N- and O-glycosylated.
messages: Belongs to the ITIH family.
messages: Cleaved by plasma kallikrein to yield 55- and 25-kDa fragments.
messages: Interacts (via C-terminus) with DNAJC1 (via SANT 2 domain).
messages: Levels increase significantly after cardiogenic shock. Specifically induced by the cytokine IL6 in hepatocytes.
messages: Liver specific.
messages: Secreted
messages: Sequencing errors.
messages: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.

9823:PRKAG3
gene id: 9823:PRKAG3
uniprot id: Q9MYP4
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism. It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity).
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.
messages: Defects in PRKAG3 are the cause of the RN- phenotype which is associated with excess glycogen content (about 70%) in skeletal muscle. This mutation originated in the hampshire breed pigs and has beneficial effects on meat content but detrimental effects on processing yield.
messages: Muscle.
messages: Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
messages: The 4 CBS domains mediate binding to nucleotides. Of the 4 potential nucleotide-binding sites, 3 are occupied, designated as sites 1, 3, and 4 based on the CBS modules that provide the acidic residue for coordination with the 2'- and 3'-hydroxyl groups of the ribose of AMP. Of these, site 4 appears to be a structural site that retains a tightly held AMP molecule (AMP 3). The 2 remaining sites, 1 and 3, can bind either AMP, ADP or ATP. Site 1 (AMP, ADP or ATP 1) is the high-affinity binding site and likely accommodates AMP or ADP. Site 3 (AMP, ADP or ATP 2) is the weakest nucleotide-binding site on the gamma subunit, yet it is exquisitely sensitive to changes in nucleotide levels and this allows AMPK to respond rapidly to changes in cellular energy status. Site 3 is likely to be responsible for protection of a conserved threonine in the activation loop of the alpha catalytic subunit through conformational changes induced by binding of AMP or ADP.
messages: The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1 (By similarity).

9823:MTFR1
gene id: 9823:MTFR1
uniprot id: A0A4X1UZU4
uniprot id: F1RTB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9823:LOC100520248
gene id: 9823:LOC100520248
uniprot id: A0A4X1STM9
names: Subcellular Location Annotation
messages: Nucleus

9823:CPEB3
gene id: 9823:CPEB3
uniprot id: A0A480JI44
uniprot id: A0A8D0XI57
uniprot id: A0A8D0XNI0
names: Similarity
messages: Belongs to the RRM CPEB family.

9823:OAT
gene id: 9823:OAT
uniprot id: A0A4X1SDH1
uniprot id: A0A8D0XDT1
uniprot id: B0LY44
uniprot id: F1SDP3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9823:ARAP3
gene id: 9823:ARAP3
uniprot id: A0A8D1PC96
names: Subcellular Location Annotation
messages: Cytoplasm

9823:MUM1L1
gene id: 9823:MUM1L1
uniprot id: A0A4X1STR3
uniprot id: F1RXM4
names: Similarity
messages: Belongs to the PWWP3A family.

9823:CST6
gene id: 9823:CST6
uniprot id: A0A4X1UDP8
uniprot id: F1RU34
names: Subcellular Location Annotation
messages: Cytoplasm

9823:NTRK1
gene id: 9823:NTRK1
uniprot id: A0A4X1VSL3
uniprot id: F1RHK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9823:LOC396685
gene id: 9823:LOC396685
uniprot id: F1SCD0
names: Similarity
messages: Belongs to the serpin family.

9823:EPHA1
gene id: 9823:EPHA1
uniprot id: A0A8D0UYY4
uniprot id: F1SRW1
names: Subcellular Location Annotation
messages: Membrane

9823:PUS7L
gene id: 9823:PUS7L
uniprot id: A0A8D1PN70
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9823:CCL2
gene id: 9823:CCL2
uniprot id: B3GDZ4
uniprot id: P42831
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Monomer or homodimer; in equilibrium. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Interacts with TNFAIP6 (via Link domain).
messages: N-Glycosylated.
messages: Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity).
messages: Secreted

9823:FAM187B
gene id: 9823:FAM187B
uniprot id: A0A8D1JSY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9823:FAM98A
gene id: 9823:FAM98A
uniprot id: A0A8D0JIH5
uniprot id: F1S408
names: Similarity
messages: Belongs to the FAM98 family.

9823:RIPOR1
gene id: 9823:RIPOR1
uniprot id: A0A4X1UL60
uniprot id: A0A4X1UMG9
uniprot id: A0A8D1Q0K3
names: Similarity
messages: Belongs to the RIPOR family.

9823:DEDD2
gene id: 9823:DEDD2
uniprot id: A0A4X1SIY1
names: Subcellular Location Annotation
messages: nucleolus

9823:MMAB
gene id: 9823:MMAB
uniprot id: A0A481CLS2
uniprot id: A0A4X1T125
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

9823:CHRM2
gene id: 9823:CHRM2
uniprot id: P06199
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
messages: Cell membrane
messages: Interacts with ARRB1 and ARRB2 (By similarity). Interacts with RACK1; the interaction regulates CHRM2 internalization.
messages: Phosphorylated in response to agonist treatment.
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.

9823:INSIG2
gene id: 9823:INSIG2
uniprot id: D2DXL3
uniprot id: Q6PQZ3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INSIG family.
messages: Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4.
messages: Endoplasmic reticulum membrane
messages: Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); association is mediated via its interaction with SCAP and only takes place in the presence of sterols. Interacts with RNF139. Interacts with RNF145.
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane
messages: Oxidized at Cys-215 in differentiated myotubes, preventing ubiquitination at the same site, and resulting in protein stabilization.
messages: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139.
messages: Phosphorylation at Ser-151 by PCK1 reduces binding to oxysterol, disrupting the interaction between INSIG2 and SCAP, thereby promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes.
messages: Polyubiquitinated by AMFR/gp78 at Cys-215 in some tissues such as adipose tissues, undifferentiated myoblasts and liver, leading to its degradation. In differentiated myotubes, Cys-215 oxidation prevents ubiquitination at the same site, resulting in protein stabilization.
messages: The KxHxx motif mediates association with the coatomer complex.

9823:THBD
gene id: 9823:THBD
uniprot id: B3STX8
names: Caution
names: Function
names: Subunit
messages: Interacts with ITGAL, ITGAM and ITGB2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

9823:ACOT8
gene id: 9823:ACOT8
uniprot id: A0A8D1QJC4
uniprot id: I3LA89
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9823:PCMT1
gene id: 9823:PCMT1
uniprot id: P80895
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (By similarity). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
messages: Monomer.
messages: cytosol

9823:TLR10
gene id: 9823:TLR10
uniprot id: Q4LDR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9823:ENDOG
gene id: 9823:ENDOG
uniprot id: A0A4X1TPJ9
uniprot id: F1RR64
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9823:PSMD4
gene id: 9823:PSMD4
uniprot id: A0A288CG47
uniprot id: A0A4X1W0B7
uniprot id: A0A8D1Q155
uniprot id: Q32YV9
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9823:S100A6
gene id: 9823:S100A6
uniprot id: Q2EN75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the S-100 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Interacts with TPPP; this interaction inhibits TPPP dimerization (By similarity).
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).
messages: Nucleus envelope

9823:C6
gene id: 9823:C6
uniprot id: A0SEH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:THBS1
gene id: 9823:THBS1
uniprot id: A0A4X1URL0
uniprot id: F1SS26
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:TJP2
gene id: 9823:TJP2
uniprot id: A0A287BAI8
uniprot id: A0A8D0KCG1
uniprot id: A0A8D0KE98
uniprot id: A0A8D0KEB3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9823:LOC100514822
gene id: 9823:LOC100514822
uniprot id: A0A8W4FGY8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NBR1
gene id: 9823:NBR1
uniprot id: A0A287AEQ4
uniprot id: A0A287BC52
uniprot id: A0A480UF11
uniprot id: A0A480UHK3
uniprot id: A0A4X1TQ30
uniprot id: A0A4X1TSF3
uniprot id: A0A4X1TV29
uniprot id: A0A4X1TV42
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9823:RRS1
gene id: 9823:RRS1
uniprot id: A0A8D1H3D5
uniprot id: F1RTZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9823:SLA-3
gene id: 9823:SLA-3
uniprot id: Q8MHT9
names: Similarity
messages: Belongs to the MHC class I family.

9823:ETV6
gene id: 9823:ETV6
uniprot id: A0A286ZXR2
uniprot id: A0A8D0YLS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:ALX1
gene id: 9823:ALX1
uniprot id: A0A287AYX1
uniprot id: A0A8D1B4G1
names: Subcellular Location Annotation
messages: Nucleus

9823:BCL9L
gene id: 9823:BCL9L
uniprot id: A0A8D2A3S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9823:EFEMP2
gene id: 9823:EFEMP2
uniprot id: A0A287ACR0
uniprot id: A0A8D2BZY5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:TDP2
gene id: 9823:TDP2
uniprot id: A0A4X1VGX0
uniprot id: A0A5G2R2R0
names: Subcellular Location Annotation
messages: PML body

9823:FABP6
gene id: 9823:FABP6
uniprot id: A0A8D0TPC0
uniprot id: P10289
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). Stimulates gastric acid and pepsinogen secretion.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Can bind at least two ligands per molecule, however, the stoichiometry is debated.
messages: Found exclusively in the ileum and to a lesser extent in distal jejunum.
messages: Membrane

9823:SNX32
gene id: 9823:SNX32
uniprot id: A0A287AWP2
uniprot id: A0A5G2QR39
uniprot id: A0A8D0PJP3
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9823:UBE2L6
gene id: 9823:UBE2L6
uniprot id: A0A8D0I1A3
uniprot id: F4ZS20
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:TCF19
gene id: 9823:TCF19
uniprot id: Q9TSV4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.

9823:GUCY2C
gene id: 9823:GUCY2C
uniprot id: A0A480MPB1
uniprot id: P55204
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Glycosylation at Asn-79 is required for interaction with VIP36 while glycosylation at Asn-402 modulates ligand-mediated GC-C activation.
messages: Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP.
messages: Homotrimer. Interacts via its C-terminal region with NHERF4. Interacts with the lectin chaperone VIP36.
messages: Membrane
messages: The protein kinase domain is predicted to be catalytically inactive.

9823:ELP5
gene id: 9823:ELP5
uniprot id: A0A4X1V0F4
uniprot id: I3LVM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

9823:LOC100519643
gene id: 9823:LOC100519643
uniprot id: A0A480T5L9
uniprot id: A0A8D0V2Z5
names: Subcellular Location Annotation
messages: Membrane

9823:DHRS9
gene id: 9823:DHRS9
uniprot id: A0A4X1VKJ7
uniprot id: A0A8D2ABI6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:VTN
gene id: 9823:VTN
uniprot id: P48819
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
messages: Monomer. Interacts with SERPINE1/PAI1 and C1QBP (By similarity).
messages: N- and O-glycosylated.
messages: Plasma.
messages: Sulfated on tyrosine residues.
messages: The SMB domain mediates interaction with SERPINE1/PAI1.
messages: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity).
messages: extracellular space

9823:PAPOLA
gene id: 9823:PAPOLA
uniprot id: A0A8D1SC85
uniprot id: F1SAQ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

9823:PPP1R14D
gene id: 9823:PPP1R14D
uniprot id: A0A4X1UR88
uniprot id: A0A8D0IN55
uniprot id: A0A8D0R085
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9823:QRSL1
gene id: 9823:QRSL1
uniprot id: A0A8D0T5W9
uniprot id: F1RT46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9823:CD93
gene id: 9823:CD93
uniprot id: A0A8D1I666
uniprot id: F1SAT8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100513311
gene id: 9823:LOC100513311
uniprot id: A0A5G2RAD9
uniprot id: A0A8D1IQM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SOX10
gene id: 9823:SOX10
uniprot id: A5A763
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Mitochondrion outer membrane
messages: Monomer. Interacts with ARMCX3 at the mitochondrial outer membrane surface. Interacts with PAX3 (By similarity).
messages: Nucleus
messages: The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.
messages: Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). Transcriptional activator of MBP, via binding to the gene promoter (By similarity).

9823:SSR4
gene id: 9823:SSR4
uniprot id: A0A4X1T3L9
uniprot id: K7GK90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9823:CFAP36
gene id: 9823:CFAP36
uniprot id: A0A4X1WBS2
uniprot id: A0A8D0K6X9
names: Similarity
messages: Belongs to the CFAP36 family.

9823:CTNND1
gene id: 9823:CTNND1
uniprot id: A0A8D0HZH3
uniprot id: A0A8D1CQE3
uniprot id: A0A8D1WG31
uniprot id: A0A8D1Z1F6
uniprot id: A0A8D2BRU5
names: Similarity
messages: Belongs to the beta-catenin family.

9823:AGPAT4
gene id: 9823:AGPAT4
uniprot id: A0A4X1VW82
uniprot id: B8XTR2
uniprot id: D0G0C1
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9823:THRA
gene id: 9823:THRA
uniprot id: A0A480Q663
uniprot id: O97716
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D. Interacts with AKAP13. Interacts with TP53INP2. Interacts with PER2 (By similarity). Interacts with PER2. Isoform alpha-2 and isoform alpha-1 interact with TACC1, but the interaction with alpha-1 is weaker. The interaction with isoform alpha-1, but not alpha-2, is decreased in the presence of thyroid hormone T3 (By similarity).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Does not bind thyroid hormone T3.
messages: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
messages: Nucleus

9823:SPO11
gene id: 9823:SPO11
uniprot id: A0A4X1UNI4
uniprot id: A0A4X1UQN6
uniprot id: A5GFN4
uniprot id: A5GFN5
names: Similarity
messages: Belongs to the TOP6A family.

9823:GRB10
gene id: 9823:GRB10
uniprot id: B5KFD7
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2 (By similarity).
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm
messages: Interacts with ligand-activated tyrosine kinase receptors, including FGFR1, INSR, IGF1R, MET and PDGFRB in a phosphotyrosine-dependent manner through the SH2 domain. Poorly binds to the EGFR. Directly interacts with MAP3K14/NIK and is recruited to the EGFR-ERBB2 complex. Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15. When unphosphorylated, interacts with AKT1 and when phosphorylated with YWHAE/14-3-3 epsilon. Interacts with NEDD4. Interacts with LRP6, thus interfering with the binding of AXIN1 to LRP6. Binds relatively non-specifically to several phosphoinositides, including PI(5)P, PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3, with modest affinities through the PH domain. Binds to activated NRAS (By similarity).
messages: Phosphorylated on serine residues upon EGF, FGF and PDGF stimulation.
messages: Phosphorylation by mTORC1 stabilizes and activates GRB10 constituting a feedback pathway by which mTORC1 inhibits INSR-dependent signaling.

9823:TBX4
gene id: 9823:TBX4
uniprot id: F8SIP7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:VPS72
gene id: 9823:VPS72
uniprot id: A0A287B4J5
uniprot id: A0A8D0T009
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9823:SLAIN2
gene id: 9823:SLAIN2
uniprot id: A0A4X1UJA2
uniprot id: A0A4X1UKL6
uniprot id: A0A5G2QXA0
uniprot id: F1SEA2
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9823:NIT1
gene id: 9823:NIT1
uniprot id: A0A287A424
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9823:WNT4
gene id: 9823:WNT4
uniprot id: A0A8D0UYS3
uniprot id: D3JCV7
uniprot id: D3K5L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:NDUFAF4
gene id: 9823:NDUFAF4
uniprot id: A0A8D2CI43
uniprot id: F1RY01
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9823:ABCC8
gene id: 9823:ABCC8
uniprot id: A0A8D1L4C9
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KCNJ11.
messages: Membrane

9823:POLR3D
gene id: 9823:POLR3D
uniprot id: A0A4X1VG16
uniprot id: F1RMB0
names: Subcellular Location Annotation
messages: Nucleus

9823:SLC45A2
gene id: 9823:SLC45A2
uniprot id: A0A5G2R2W6
names: Subcellular Location Annotation
messages: Membrane

9823:HOXB2
gene id: 9823:HOXB2
uniprot id: A0A8D0ZNI3
uniprot id: F1RWG7
names: Subcellular Location Annotation
messages: Nucleus

9823:SF1
gene id: 9823:SF1
uniprot id: A0A480TKX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

9823:EIF4H
gene id: 9823:EIF4H
uniprot id: A0A480PPD4
uniprot id: A0A4X1UV55
uniprot id: A0A8D1GIQ2
uniprot id: I3LRD5
names: Function
names: Subcellular Location Annotation
messages: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
messages: perinuclear region

9823:LOC100157935
gene id: 9823:LOC100157935
uniprot id: A0A4X1SL06
uniprot id: F1SD52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9823:SARDH
gene id: 9823:SARDH
uniprot id: A0A287B4Z6
names: Similarity
messages: Belongs to the GcvT family.

9823:TSPAN17
gene id: 9823:TSPAN17
uniprot id: A0A287AQI5
uniprot id: A0A4X1SIL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:TMEM167B
gene id: 9823:TMEM167B
uniprot id: A0A4X1TG88
uniprot id: A0A8D1SQU4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:TMEM39A
gene id: 9823:TMEM39A
uniprot id: A0A8D1PD65
uniprot id: F1SPA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9823:FURIN
gene id: 9823:FURIN
uniprot id: A0A8D1TM49
uniprot id: F1RMJ1
names: Similarity
messages: Belongs to the peptidase S8 family.

9823:HBQ1
gene id: 9823:HBQ1
uniprot id: A0A4X1UMQ7
uniprot id: K7GNR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9823:CDK3
gene id: 9823:CDK3
uniprot id: A0A4X1UV46
uniprot id: A0A4X1UYK5
uniprot id: A0A8D0P3P0
uniprot id: A0A8D1JAU3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:LOC100510904
gene id: 9823:LOC100510904
uniprot id: A0A287BQW3
uniprot id: A0A8D1FQW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9823:CITED1
gene id: 9823:CITED1
uniprot id: A0A287ALJ7
uniprot id: A0A287B8H9
uniprot id: A0A4X1VW13
uniprot id: A0A4X1W323
uniprot id: A0A8D1CUE4
uniprot id: Q2VIU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9823:ERCC1
gene id: 9823:ERCC1
uniprot id: A0A8D0XIB8
uniprot id: A0A8D1QFQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

9823:EXOSC9
gene id: 9823:EXOSC9
uniprot id: A0A8D0KB04
names: Subcellular Location Annotation
messages: Cytoplasm

9823:OBP
gene id: 9823:OBP
uniprot id: A0A8D1W4I4
uniprot id: Q8WMH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9823:FRZB
gene id: 9823:FRZB
uniprot id: A0A4X1SQG3
uniprot id: A0A8D0KE81
names: Caution
names: Function
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9823:ARSA
gene id: 9823:ARSA
uniprot id: A0A4X1UHZ0
uniprot id: Q8WNR3
names: Similarity
messages: Belongs to the sulfatase family.

9823:RFC5
gene id: 9823:RFC5
uniprot id: A0A4X1TT89
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9823:CPB2
gene id: 9823:CPB2
uniprot id: A0A8D1BB67
uniprot id: F1RK01
names: Similarity
messages: Belongs to the peptidase M14 family.

9823:MC1R
gene id: 9823:MC1R
uniprot id: Q95MM8
uniprot id: Q9TU05
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH (By similarity). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:9799269).
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Variation is correlated with coat color. MC1R*2 is associated with the black color of European large black and Chinese meishan pigs. MC1R*3 is associated with the black color in the hampshire breed. MC1R*4 is found in recessive red animals.

9823:MRPL36
gene id: 9823:MRPL36
uniprot id: A0A8D0S053
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

9823:OGN
gene id: 9823:OGN
uniprot id: A0A0H5ANC0
uniprot id: A0A8D0X3E2
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9823:CAPZB
gene id: 9823:CAPZB
uniprot id: A0A8D1Q0S8
uniprot id: A0PFK7
uniprot id: D2JYW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (PubMed:36071160, PubMed:25814576, PubMed:29420470, PubMed:33734450). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).
messages: Heterodimer of an alpha and a beta subunit (PubMed:29420470, PubMed:33734450, PubMed:36071160). Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3 (PubMed:33734450, PubMed:36071160). The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6 (PubMed:33734450). The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin (PubMed:33734450, PubMed:36071160). Interacts with ARHGAP17. Interaction with RCSD1/CAPZIP. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. Interacts with ACTG1. Directly interacts with CRACD; this interaction decreases binding to actin (By similarity).
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton
messages: sarcomere

9823:GSX2
gene id: 9823:GSX2
uniprot id: A0A4X1UAB5
uniprot id: F1SE61
names: Subcellular Location Annotation
messages: Nucleus

9823:GATM
gene id: 9823:GATM
uniprot id: P50441
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the amidinotransferase family.
messages: Expressed in placenta on days 75 and 90 of gestation.
messages: Homodimer.
messages: Kidney. Expressed biallelically in placenta.
messages: Mitochondrion inner membrane
messages: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives (By similarity). Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (By similarity).

9823:MRPS18B
gene id: 9823:MRPS18B
uniprot id: L0GCT6
uniprot id: Q767K8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

9823:IL22RA2
gene id: 9823:IL22RA2
uniprot id: A0A8D1A7D9
uniprot id: A0A8D1YCL6
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100516295
gene id: 9823:LOC100516295
uniprot id: A0A4X1TWR8
uniprot id: A0A8W4FQL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9823:RPLP2
gene id: 9823:RPLP2
uniprot id: A0A4X1VXC8
uniprot id: A0A8D0KLS8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9823:DYNLL2
gene id: 9823:DYNLL2
uniprot id: A0A4X1SJK3
uniprot id: A0A8D1B0S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9823:ITPK1
gene id: 9823:ITPK1
uniprot id: A0A8D0ZQ38
uniprot id: B8XSJ6
names: Similarity
messages: Belongs to the ITPK1 family.

9823:LDHA
gene id: 9823:LDHA
uniprot id: A0A4X1T6G7
uniprot id: D2SW96
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9823:CCL17
gene id: 9823:CCL17
uniprot id: A0A8D1DD60
uniprot id: G8XRI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:SLC25A28
gene id: 9823:SLC25A28
uniprot id: A0A286ZJV0
uniprot id: A0A8D1FUV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:NEU1
gene id: 9823:NEU1
uniprot id: A5PF10
uniprot id: B9TSS6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A C-terminal internalization signal (YGTL) appears to allow the targeting of plasma membrane proteins to endosomes.
messages: Belongs to the glycosyl hydrolase 33 family.
messages: Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage (By similarity).
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with cathepsin A (protective protein), beta-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.
messages: Lysosome lumen
messages: Lysosome membrane
messages: N-glycosylated.
messages: Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane.

9823:LOC100622246
gene id: 9823:LOC100622246
uniprot id: A0A0K1TQQ7
uniprot id: A0A4X1TQY2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9823:ANXA11
gene id: 9823:ANXA11
uniprot id: A0A8D1PS82
uniprot id: F1S2E2
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9823:KEF22 p03
gene id: 9823:KEF22_p03
uniprot id: Q9TDR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9823:EPS8
gene id: 9823:EPS8
uniprot id: A0A481CLQ6
uniprot id: A0A4X1VAP6
names: Similarity
messages: Belongs to the EPS8 family.

9823:WNT2
gene id: 9823:WNT2
uniprot id: A0A287B4Y7
uniprot id: A0A8D0TY96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:PIK3CD
gene id: 9823:PIK3CD
uniprot id: A0A5K1UPW2
uniprot id: A0A8D0WQF3
uniprot id: A0A8D1VQB8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9823:KRT82
gene id: 9823:KRT82
uniprot id: A0A4X1WC00
uniprot id: A0A8D0Z3D2
names: Similarity
messages: Belongs to the intermediate filament family.

9823:HK3
gene id: 9823:HK3
uniprot id: A0A287AE54
uniprot id: A0A4X1SIK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9823:BMP10
gene id: 9823:BMP10
uniprot id: A0A287A7C6
uniprot id: A0A8D1DM66
names: Similarity
messages: Belongs to the TGF-beta family.

9823:LOC100511937
gene id: 9823:LOC100511937
uniprot id: A0A4X1W4S4
uniprot id: A0A8D0KD06
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9823:SYK
gene id: 9823:SYK
uniprot id: Q00655
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autoinhibited. Intramolecular binding of the interdomains A and B (also called linker region) to parts of the catalytic domain keep the catalytic center in an inactive conformation. The phosphorylation of the interdomains or the binding of the SH2 domains with dually phosphorylated ITAM domains on transmembrane proteins disrupt those intramolecular interactions allowing the kinase domain to adopt an active conformation. The phosphorylation of SYK and of the ITAM domains which is responsible for SYK activation is essentially mediated by SRC subfamily kinases, like LYN, upon transmembrane receptors engagement (By similarity). May also be negatively regulated by PTPN6 through dephosphorylation (By similarity). Downstream signaling adapters and intermediates like BLNK or RHOH may mediate positive and/or negative feedback regulation (By similarity). Negatively regulated by CBL and CBLB through ubiquitination and probable degradation (By similarity). Phosphorylates SH3BP2 which in turn may regulate SYK through LYN.
messages: Autophosphorylated. Phosphorylated on tyrosine residues by LYN following receptors engagement. Phosphorylation on Tyr-316 creates a binding site for CBL, an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling. Phosphorylation at Tyr-341 creates a binding site for VAV1 (By similarity). Phosphorylation on Tyr-341 and Tyr-345 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3-kinase-independent pathway (By similarity). Phosphorylated on tyrosine residues in response to IL15 (By similarity). Phosphorylation on Ser-290 is very common, it peaks 5 minutes after BCR stimulation, and creates a binding site for YWHAG (By similarity). Phosphorylation at Tyr-623 creates a binding site for BLNK (By similarity). Dephosphorylated by PTPN6 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
messages: Cell membrane
messages: Interacts with LYN; phosphorylates SYK. Interacts with RHOH (phosphorylated); regulates mast cells activation (By similarity). Interacts with NFAM1 (phosphorylated); probably involved in BCR signaling (By similarity). Interacts with VAV1 (via SH2 domain); phosphorylates VAV1 upon BCR activation. Interacts with GAB2 (phosphorylated); probably involved in IgE Fc receptor signaling (By similarity). Interacts (via its SH2 domains) with CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and activation (By similarity). Interacts (via SH2 domains) with FCER1G (via ITAM domain); activates SYK and mediates neutrophils and macrophages integrin-mediated activation (By similarity). Interaction with FCER1G in basophils triggers IL3-induced IL4 production (By similarity). Interacts with ITGB2 and FGR; involved in ITGB2 downstream signaling (By similarity). Interacts with ITGB3; upon activation by ITGB3 promotes platelet adhesion (By similarity). Interacts (via SH2 domains) with TYROBP (via ITAM domain); involved in neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with MSN and SELPLG; mediates the selectin-dependent activation of SYK by SELPLG (By similarity). Interacts with BLNK (via SH2 domain) (By similarity). Interacts (via the second SH2 domain) with USP25 (via C-terminus); phosphorylates USP25 and regulates USP25 intracellular levels (By similarity). Interacts (via SH2 domains) with CLEC1B (dimer) (By similarity). Interacts with CLEC7A; participates in leukocyte activation in presence of fungal pathogens (By similarity). Interacts (phosphorylated) with SLA; may regulate SYK through CBL recruitment (By similarity). Interacts with YWHAG; attenuates BCR-induced membrane translocation and activation of SYK (By similarity). Interacts (via SH2 domains) with GCSAM; the interaction increases after B-cell receptor stimulation, resulting in enhanced SYK autophosphorylation and activity (By similarity).Inter…
messages: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through …
messages: Shows high susceptibility to proteolysis.
messages: Spleen and with lesser amounts in thymus.
messages: The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins. Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL motif. The interaction with SYK requires CLEC1B homodimerization (By similarity).
messages: Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation.
messages: cytosol

9823:POP5
gene id: 9823:POP5
uniprot id: A0A8D1V907
uniprot id: F1RJI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9823:CCR9
gene id: 9823:CCR9
uniprot id: A0A4X1T8C4
uniprot id: Q6YT47
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:FAM91A1
gene id: 9823:FAM91A1
uniprot id: A0A480DGD4
uniprot id: A0A8D2A020
names: Similarity
messages: Belongs to the FAM91 family.

9823:NR2F1
gene id: 9823:NR2F1
uniprot id: A0A4X1TCJ9
uniprot id: F1RNX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:SLC25A34
gene id: 9823:SLC25A34
uniprot id: A0A480RCV7
uniprot id: A0A8D1TEY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:CCNK
gene id: 9823:CCNK
uniprot id: A0A480QNH9
names: Similarity
messages: Belongs to the cyclin family.

9823:MINDY1
gene id: 9823:MINDY1
uniprot id: A0A8D0MHE0
uniprot id: F1SS98
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9823:CRY1
gene id: 9823:CRY1
uniprot id: A0A480LD13
uniprot id: A0A8D0I4U3
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

9823:THOC2
gene id: 9823:THOC2
uniprot id: A0A287AC85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

9823:LOC100525798
gene id: 9823:LOC100525798
uniprot id: A0A4X1W1C3
uniprot id: F1RPL0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9823:LOC100524975
gene id: 9823:LOC100524975
uniprot id: A0A4X1V0K4
uniprot id: F1SA00
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FBXO32
gene id: 9823:FBXO32
uniprot id: Q1A730
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Nucleus
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity).

9823:NOC4L
gene id: 9823:NOC4L
uniprot id: A0A287BAD7
uniprot id: A0A8D1BNC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Nucleus membrane

9823:CDX2
gene id: 9823:CDX2
uniprot id: D0V4H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9823:NPHS2
gene id: 9823:NPHS2
uniprot id: A0A8D0XB96
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9823:DNPH1
gene id: 9823:DNPH1
uniprot id: A0A4X1V874
uniprot id: F1RRM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus

9823:PRM2
gene id: 9823:PRM2
uniprot id: P19757
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protamine P2 family.
messages: Chromosome
messages: Interacts with TDRP.
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Proteolytic processing into mature chains is required for histone eviction during spermatogenesis. Transition proteins (TNP1 and TNP2) are required for processing.
messages: Testis.

9823:CNNM2
gene id: 9823:CNNM2
uniprot id: A0A287AM25
uniprot id: A0A8D0VJ22
uniprot id: A0A8D1I237
uniprot id: F1S849
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9823:BUD23
gene id: 9823:BUD23
uniprot id: A0A480VBS0
uniprot id: A0A8D0ZGN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

9823:MRPS16
gene id: 9823:MRPS16
uniprot id: A0A480JTD7
uniprot id: A0A8D1RWM4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9823:TBX22
gene id: 9823:TBX22
uniprot id: A0A8D1XEK5
uniprot id: F1RPF2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:MMP7
gene id: 9823:MMP7
uniprot id: F1SV71
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9823:ANKRD34C
gene id: 9823:ANKRD34C
uniprot id: A0A286ZNJ4
names: Similarity
messages: Belongs to the ANKRD34 family.

9823:CPT1B
gene id: 9823:CPT1B
uniprot id: Q5US13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:MXRA8
gene id: 9823:MXRA8
uniprot id: A0A287AKH1
uniprot id: A0A8D0VQP7
uniprot id: A0A8D1DAQ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:PNRC2
gene id: 9823:PNRC2
uniprot id: A0A8D0UL44
uniprot id: I3LST4
names: Subcellular Location Annotation
messages: Nucleus

9823:ACAA2
gene id: 9823:ACAA2
uniprot id: A0A8D0Z858
uniprot id: D0G0B3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9823:RBM48
gene id: 9823:RBM48
uniprot id: A0A8D0RME0
uniprot id: A0A8D1IM59
names: Function
names: Similarity
names: Subunit
messages: As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: Belongs to the RBM48 family.
messages: Component of the minor spliceosome. Within this complex, interacts with ARMC7 and PRPF8/PRP8.

9823:RBFOX2
gene id: 9823:RBFOX2
uniprot id: A0A480LBN6
uniprot id: A0A480R3E1
uniprot id: A0A4X1TT75
uniprot id: A0A4X1TTR6
uniprot id: A0A8D1FQN1
uniprot id: A0A8D1FRH7
uniprot id: A0A8D1V6T6
uniprot id: F1SPT7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9823:ZFYVE27
gene id: 9823:ZFYVE27
uniprot id: A0A287BL02
uniprot id: A0A8D0JF29
uniprot id: A0A8D1NW03
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

9823:DNAJA2
gene id: 9823:DNAJA2
uniprot id: A0A4X1TXQ3
uniprot id: F1RP05
names: Subcellular Location Annotation
messages: Membrane

9823:GUCY1A3
gene id: 9823:GUCY1A3
uniprot id: A0A4X1U7Y5
uniprot id: Q4ZHR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9823:ACTR3
gene id: 9823:ACTR3
uniprot id: B5APU4
names: Similarity
messages: Belongs to the actin family.

9823:CAMKK2
gene id: 9823:CAMKK2
uniprot id: A0A480WNA1
uniprot id: A0A8D0M9W4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:HDAC2
gene id: 9823:HDAC2
uniprot id: A0A4X1V7Y5
uniprot id: F1RZK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9823:ARF5
gene id: 9823:ARF5
uniprot id: A0A8D0XRH3
uniprot id: B9V4F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9823:FHL5
gene id: 9823:FHL5
uniprot id: A0A4X1VD49
uniprot id: A0A8D1A6S7
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9823:PRPF3
gene id: 9823:PRPF3
uniprot id: B6DT14
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9823:TUBD1
gene id: 9823:TUBD1
uniprot id: A0A287B840
uniprot id: A0A8D1UBM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9823:RCAN1
gene id: 9823:RCAN1
uniprot id: A0A286ZTF9
uniprot id: A0A4X1TV21
uniprot id: A0A8D1WPN6
uniprot id: F1SGX6
names: Similarity
messages: Belongs to the RCAN family.

9823:SUPT16H
gene id: 9823:SUPT16H
uniprot id: A0A4X1UV99
uniprot id: F1S8K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9823:HVCN1
gene id: 9823:HVCN1
uniprot id: A0A4X1U1H6
uniprot id: F1RNL6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9823:ENSA
gene id: 9823:ENSA
uniprot id: P68211
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Interacts (when phosphorylated at Ser-67) with PPP2R2D. Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109 (By similarity).
messages: Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA (By similarity).
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity).
messages: The N-terminus is blocked.

9823:CMKLR1
gene id: 9823:CMKLR1
uniprot id: B1PHQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Predominantly expressed in spleen and temperately in adipose tissue.
messages: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity).

9823:VANGL1
gene id: 9823:VANGL1
uniprot id: A0A4X1SXH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9823:ORMDL2
gene id: 9823:ORMDL2
uniprot id: A0A4X1W415
uniprot id: A0A8D0P3T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9823:EEF1B2
gene id: 9823:EEF1B2
uniprot id: A0A4X1V2W3
uniprot id: A0A8D1U905
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9823:TLR9
gene id: 9823:TLR9
uniprot id: Q865R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
messages: Lysosome
messages: Membrane
messages: phagosome

9823:LTB4R2
gene id: 9823:LTB4R2
uniprot id: A0A8D0TKC4
uniprot id: I3LIW2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:NDEL1
gene id: 9823:NDEL1
uniprot id: A0A4X1V637
uniprot id: A0A4X1V9G4
uniprot id: A0A8D0JQH5
uniprot id: A0A8D1AZY7
uniprot id: A0A8D1JIE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9823:ATPAF1
gene id: 9823:ATPAF1
uniprot id: A0A8D1F5W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

9823:TNNC1
gene id: 9823:TNNC1
uniprot id: P63317
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the troponin C family.
messages: Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.
messages: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

9823:ASPH
gene id: 9823:ASPH
uniprot id: A0A4X1V4I1
names: Subcellular Location Annotation
messages: Membrane

9823:ATP7A
gene id: 9823:ATP7A
uniprot id: A0A4X1SGI5
uniprot id: A0A4X1SGS3
uniprot id: A0A5K1U0J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9823:LOC100516606
gene id: 9823:LOC100516606
uniprot id: A0A4X1SP87
uniprot id: A0A4X1SQS6
uniprot id: A0A8D0RN06
uniprot id: A0A8D1LT61
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9823:ATP13A2
gene id: 9823:ATP13A2
uniprot id: A0A8D1L3V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9823:DEFB128
gene id: 9823:DEFB128
uniprot id: A0A287BN95
uniprot id: A0A4X1SQJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:TMEM87A
gene id: 9823:TMEM87A
uniprot id: A0A287B758
uniprot id: A0A8D1ZDW1
uniprot id: A0A8D1ZJV5
uniprot id: F1SFK6
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100151870
gene id: 9823:LOC100151870
uniprot id: A0A4X1SXI7
uniprot id: F1RRS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9823:POLA2
gene id: 9823:POLA2
uniprot id: A0A8D1HH88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

9823:ZKSCAN5
gene id: 9823:ZKSCAN5
uniprot id: A0A480HRD0
uniprot id: A0A8D1A6D1
uniprot id: A0A8D1S0Q8
names: Subcellular Location Annotation
messages: Nucleus

9823:UNG
gene id: 9823:UNG
uniprot id: A0A287B576
uniprot id: A0A4X1STA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Monomer. Interacts with FAM72A.
messages: Nucleus

9823:METAP1
gene id: 9823:METAP1
uniprot id: A0A480L5Q2
uniprot id: A0A4X1UH72
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9823:RXFP4
gene id: 9823:RXFP4
uniprot id: A0A4X1VU72
uniprot id: Q5Y982
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:LOC100516987
gene id: 9823:LOC100516987
uniprot id: A0A287BF74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ANXA10
gene id: 9823:ANXA10
uniprot id: A0A8D1CYU2
uniprot id: I3LFK6
names: Similarity
messages: Belongs to the annexin family.

9823:LITAF
gene id: 9823:LITAF
uniprot id: A0A4X1VJC1
uniprot id: A0A8D0LNY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9823:ATP6V0A2
gene id: 9823:ATP6V0A2
uniprot id: A0A4X1UMB6
uniprot id: A0A8D2C4S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9823:GALM
gene id: 9823:GALM
uniprot id: A0A480TQM9
uniprot id: Q9GKX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Cytoplasm
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.

9823:SOX9
gene id: 9823:SOX9
uniprot id: O18896
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated; acetylation impairs nuclear localization and ability to transactivate expression of target genes. Deacetylated by SIRT1.
messages: Homodimer; homodimerization is required for activity. Interacts (via C-terminus) with ZNF219; forming a complex that binds to the COL2A1 promoter and activates COL2A1 expression (By similarity). Interacts with DDRGK1. Interacts with EP300/p300 (By similarity). Interacts with beta-catenin (CTNNB1); inhibiting CTNNB1 activity by competing with the binding sites of TCF/LEF within CTNNB1 (By similarity).
messages: Nucleus
messages: Phosphorylation at Ser-64 and Ser-211 by PKA increases transcriptional activity and may help delay chondrocyte maturation downstream of PTHLH/PTHrP signaling. Phosphorylation at either Ser-64 or Ser-211 is required for sumoylation, but phosphorylation is not dependent on sumoylation. Phosphorylated on tyrosine residues; tyrosine dephosphorylation by PTPN11/SHP2 blocks SOX9 phosphorylation by PKA and subsequent SUMOylation.
messages: Sumoylated; phosphorylation at either Ser-64 or Ser-211 is required for sumoylation. Sumoylation is induced by BMP signaling pathway.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: The PQA region (for proline, glutamine and alanine-rich) helps stabilize SOX9 and facilitates transactivation. It lacks intrinsic transactivation capability.
messages: The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.
messages: Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6. Also binds to some promoter regions. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis. Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression. Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C. Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes. Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors. In addition to cartilage development, also acts as a regulator of proliferation and differentiation in…
messages: Ubiquitinated; ubiquitination leads to proteasomal degradation and is negatively regulated by DDRGK1.

9823:PSMA5
gene id: 9823:PSMA5
uniprot id: A0A8D1J091
uniprot id: F2Z5K2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9823:RPP30
gene id: 9823:RPP30
uniprot id: A0A5G2QIB1
uniprot id: A0A8D1R6B1
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

9823:GUCY1A2
gene id: 9823:GUCY1A2
uniprot id: A0A4X1V6P0
uniprot id: I3L9I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9823:CRYGS
gene id: 9823:CRYGS
uniprot id: A0A4X1SFK9
uniprot id: A0A8D0VL98
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9823:ANO4
gene id: 9823:ANO4
uniprot id: A0A4X1SW93
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:GRB14
gene id: 9823:GRB14
uniprot id: A0A480SVQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9823:KCNC3
gene id: 9823:KCNC3
uniprot id: A0A287AXA6
uniprot id: A0A4X1VUW0
uniprot id: A0A8D2C8F5
uniprot id: F1RH35
names: Subcellular Location Annotation
messages: Membrane

9823:MTTP
gene id: 9823:MTTP
uniprot id: A0A480UDD3
uniprot id: Q865F1
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (By similarity). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Heterodimer; heterodimerizes with the protein disulfide isomerase (P4HB/PDI). Interacts with APOB (By similarity). Interacts with PRAP1 (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CYP51
gene id: 9823:CYP51
uniprot id: A0A480ND90
uniprot id: O46420
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: In testis, expression levels are low in young animals and increase rapidly after 10 weeks of age.
messages: Inhibited by azalanstat. Inhibited by azole antifungal agents ketoconazole, itraconazole and fluconazole.
messages: Microsome membrane
messages: Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis. Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis. Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL.
messages: Strongly expressed in liver and testis. Also detected in kidney, lung and epididymis.

9823:SEC22C
gene id: 9823:SEC22C
uniprot id: A0A287AJP5
uniprot id: A0A8D0TTS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9823:ALOX12
gene id: 9823:ALOX12
uniprot id: A0A8D0Y413
uniprot id: F1RF49
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:MAPK8IP3
gene id: 9823:MAPK8IP3
uniprot id: A0A480T4I2
uniprot id: A0A480T797
uniprot id: A0A8D1A920
uniprot id: F1RG15
names: Similarity
messages: Belongs to the JIP scaffold family.

9823:ATG2A
gene id: 9823:ATG2A
uniprot id: D7RA21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9823:ASPHD1
gene id: 9823:ASPHD1
uniprot id: A0A4X1U2Y4
uniprot id: A0A8D0T4G9
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9823:CLTC
gene id: 9823:CLTC
uniprot id: A0A8D1ZIN9
uniprot id: C0MHR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9823:FUNDC2
gene id: 9823:FUNDC2
uniprot id: Q864V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (By similarity). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (By similarity).
messages: Mitochondrion outer membrane
messages: Nucleus

9823:EAF2
gene id: 9823:EAF2
uniprot id: A0A4X1T933
uniprot id: F1SQ18
names: Similarity
messages: Belongs to the EAF family.

9823:FAM53C
gene id: 9823:FAM53C
uniprot id: A0A480S1G0
uniprot id: A0A8D1IZ10
names: Similarity
messages: Belongs to the FAM53 family.

9823:ATG9B
gene id: 9823:ATG9B
uniprot id: D7RA33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9823:LOC100514087
gene id: 9823:LOC100514087
uniprot id: A0A287BI54
uniprot id: A0A4X1W9L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FUT8
gene id: 9823:FUT8
uniprot id: A0A480QKH0
uniprot id: A0A8D1GLP5
uniprot id: P79282
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Highest expression in brain.
messages: Membrane
messages: Tyrosine phosphorylated by PKDCC/VLK.

9823:GNA13
gene id: 9823:GNA13
uniprot id: A0A287A853
uniprot id: A0A8D1KZL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9823:PALM3
gene id: 9823:PALM3
uniprot id: A0A4X1V4V0
names: Similarity
messages: Belongs to the paralemmin family.

9823:TMEM106A
gene id: 9823:TMEM106A
uniprot id: A0A480WV09
uniprot id: A0A480ZC76
uniprot id: A0A4X1TU65
uniprot id: A0A8D1GZV4
names: Similarity
messages: Belongs to the TMEM106 family.

9823:MEPCE
gene id: 9823:MEPCE
uniprot id: A0A480IT56
uniprot id: A0A4X1U8N9
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9823:HOXA3
gene id: 9823:HOXA3
uniprot id: A0A4X1TUG9
uniprot id: F1SHT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:LOC100737875
gene id: 9823:LOC100737875
uniprot id: A0A480EBE0
uniprot id: A0A8D1IYS9
names: Subcellular Location Annotation
messages: Membrane

9823:FAM133A
gene id: 9823:FAM133A
uniprot id: A0A4X1W5N4
uniprot id: K7GR11
names: Similarity
messages: Belongs to the FAM133 family.

9823:CCR5
gene id: 9823:CCR5
uniprot id: A0A4X1TA26
uniprot id: Q6YT41
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:RTN2
gene id: 9823:RTN2
uniprot id: Q6IM67
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:RC3H2
gene id: 9823:RC3H2
uniprot id: A0A4X1UHA7
uniprot id: A0A8D1ABB2
names: Subcellular Location Annotation
messages: P-body

9823:LOC100517239
gene id: 9823:LOC100517239
uniprot id: A0A4X1T869
uniprot id: A0A8D1L1Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SMC4
gene id: 9823:SMC4
uniprot id: A0A4X1VG91
uniprot id: A0A8D1A0H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Chromosome
messages: Nucleus

9823:LOC100511343
gene id: 9823:LOC100511343
uniprot id: A0A4X1SJP5
uniprot id: I3LMQ0
names: Similarity
messages: Belongs to the CD36 family.

9823:PHAX
gene id: 9823:PHAX
uniprot id: A0A286ZSR2
uniprot id: A0A4X1UGE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

9823:SEMA3F
gene id: 9823:SEMA3F
uniprot id: A0A287A3E9
uniprot id: A0A4X1SLE3
uniprot id: A0A4X1SLF6
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:FAM83B
gene id: 9823:FAM83B
uniprot id: F1RZW2
names: Similarity
messages: Belongs to the FAM83 family.

9823:BYSL
gene id: 9823:BYSL
uniprot id: B4X981
names: Similarity
messages: Belongs to the bystin family.

9823:LOC106504899
gene id: 9823:LOC106504899
uniprot id: A0A5G2QWZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100515166
gene id: 9823:LOC100515166
uniprot id: A0A5G2RAS7
uniprot id: A0A8D1XJT1
names: Similarity
messages: Belongs to the intermediate filament family.

9823:DERL3
gene id: 9823:DERL3
uniprot id: A0A287B4M0
uniprot id: A0A4X1V0C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9823:CKMT2
gene id: 9823:CKMT2
uniprot id: A0A8D0T8C8
uniprot id: Q2HYU1
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9823:TOMM22
gene id: 9823:TOMM22
uniprot id: A0A4X1VL74
uniprot id: F1SLC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9823:TCTN3
gene id: 9823:TCTN3
uniprot id: A0A8D1KRB3
uniprot id: A0A8D1TLP6
uniprot id: F1SC46
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9823:AQP2
gene id: 9823:AQP2
uniprot id: A0A8D0I9I9
uniprot id: I3LH92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:HGFAC
gene id: 9823:HGFAC
uniprot id: A0A480QPG5
uniprot id: A0A8D1CH00
uniprot id: A0A8D1FZI2
uniprot id: F1S8N1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:FASN
gene id: 9823:FASN
uniprot id: A5YV76
names: Function
messages: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

9823:PPP1R12C
gene id: 9823:PPP1R12C
uniprot id: A0A480QI27
uniprot id: I3LEG2
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9823:GPR87
gene id: 9823:GPR87
uniprot id: A0A287AN17
uniprot id: A0A8D0PQN3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:FAM216B
gene id: 9823:FAM216B
uniprot id: A0A287BMM3
uniprot id: A0A8D0ZJD7
uniprot id: A0A8D1LME1
uniprot id: F1RJX2
names: Similarity
messages: Belongs to the FAM216 family.

9823:MSRB2
gene id: 9823:MSRB2
uniprot id: A0A4X1TRP8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9823:GAL3ST4
gene id: 9823:GAL3ST4
uniprot id: A0A8D1ZRT4
uniprot id: F1RNN6
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9823:FAM19A3
gene id: 9823:FAM19A3
uniprot id: A0A4X1T5X2
names: Similarity
messages: Belongs to the TAFA family.

9823:MMP20
gene id: 9823:MMP20
uniprot id: P79287
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autoactivates at least at the 107-Asn-|-Tyr-108 site.
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Calcium ions per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).
messages: Expressed specifically in the enamel organ.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

9823:LOC100151899
gene id: 9823:LOC100151899
uniprot id: A0A4X1UY63
uniprot id: F1S9A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TCTN2
gene id: 9823:TCTN2
uniprot id: A0A480JYQ3
uniprot id: A0A4X1ULL0
uniprot id: A0A4X1UMW8
uniprot id: F1RFL8
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9823:LOC100516070
gene id: 9823:LOC100516070
uniprot id: A0A287BEC9
uniprot id: A0A4X1U0A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100519092
gene id: 9823:LOC100519092
uniprot id: A0A287AW51
uniprot id: A0A4X1TB81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PAQR4
gene id: 9823:PAQR4
uniprot id: A0A4X1VVI1
uniprot id: I3LP82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:FXYD6
gene id: 9823:FXYD6
uniprot id: A0A4X1SVR1
names: Similarity
messages: Belongs to the FXYD family.

9823:SLC16A1
gene id: 9823:SLC16A1
uniprot id: A0A8D1JG73
uniprot id: B2CZF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9823:FAP
gene id: 9823:FAP
uniprot id: A0A4X1VML4
uniprot id: A0A8D0Z5S1
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9823:NOG
gene id: 9823:NOG
uniprot id: A0A8D1L1P4
uniprot id: B8XVN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9823:SMIM22
gene id: 9823:SMIM22
uniprot id: A0A4X1VTF1
uniprot id: A0A8W4FBL3
names: Subcellular Location Annotation
messages: Membrane

9823:CDNF
gene id: 9823:CDNF
uniprot id: A0A8D1C4Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9823:FGB
gene id: 9823:FGB
uniprot id: A0A480TMT6
uniprot id: A0A8D1G7X5
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9823:CD40LG
gene id: 9823:CD40LG
uniprot id: E1AXT9
uniprot id: Q95MQ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).
messages: Homotrimer.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9823:BUD31
gene id: 9823:BUD31
uniprot id: A0A4X1U3H4
uniprot id: K7N7E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9823:GREM2
gene id: 9823:GREM2
uniprot id: A0A4X1TI36
uniprot id: F1S9G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9823:B3GNT8
gene id: 9823:B3GNT8
uniprot id: A0A286ZLM1
uniprot id: A0A8D0QP03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:UTP18
gene id: 9823:UTP18
uniprot id: A0A8D1REA8
uniprot id: F1RSH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

9823:EIF1AY
gene id: 9823:EIF1AY
uniprot id: A0A4X1TKG2
uniprot id: A0A8D0IR61
uniprot id: A0A8D0J2T5
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.

9823:CACNG1
gene id: 9823:CACNG1
uniprot id: Q2MJQ7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: N-glycosylated.
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

9823:SLC25A25
gene id: 9823:SLC25A25
uniprot id: A0A4X1U630
uniprot id: C8C417
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9823:SCN3B
gene id: 9823:SCN3B
uniprot id: A0A4X1VHU4
uniprot id: A0A8D0Q4B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9823:HIGD1A
gene id: 9823:HIGD1A
uniprot id: A0A8D0W5D7
uniprot id: F1SRE7
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9823:IFN-ALPHAOMEGA
gene id: 9823:IFN-ALPHAOMEGA
uniprot id: A0A8D0YZ30
uniprot id: C8CKA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:DAO
gene id: 9823:DAO
uniprot id: P00371
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAMOX/DASOX family.
messages: Homodimer.
messages: Peroxisome
messages: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

9823:CD163
gene id: 9823:CD163
uniprot id: Q2VL90
names: Caution
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs (By similarity).
messages: After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
messages: Cell membrane
messages: Expressed in monocytes and macrophages. Detected only in one population of monocytes (CD163+) which is in advanced maturation stage.
messages: Interacts with CSNK2B.
messages: Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.
messages: It is uncertain whether Met-1 or Met-6 is the initiator.
messages: Phosphorylated.
messages: Secreted
messages: Suppressed when monocytes are differentiated towards dendritic cells by CSF1 and IL4.
messages: The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes.

9823:EIF3K
gene id: 9823:EIF3K
uniprot id: A0A480THF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9823:EPHA2
gene id: 9823:EPHA2
uniprot id: A0A8D0UGQ1
uniprot id: F1SUT8
names: Subcellular Location Annotation
messages: Membrane

9823:PGM1
gene id: 9823:PGM1
uniprot id: G0Z3A1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9823:PRLHR
gene id: 9823:PRLHR
uniprot id: A0A4X1SXX5
uniprot id: F1S4P9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:DBT
gene id: 9823:DBT
uniprot id: A0A4X1TTF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9823:AAR2
gene id: 9823:AAR2
uniprot id: A0A8D0WHX7
uniprot id: F1S484
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

9823:KDR
gene id: 9823:KDR
uniprot id: A0A4X1U5F1
uniprot id: A0A8D1J326
uniprot id: K7GNF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9823:RNF157
gene id: 9823:RNF157
uniprot id: A0A4X1UXB9
uniprot id: F1RWM8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9823:LOC100737385
gene id: 9823:LOC100737385
uniprot id: A0A8D0R355
uniprot id: F1SA36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PAXBP1
gene id: 9823:PAXBP1
uniprot id: A0A8D0P6W3
uniprot id: F1SH07
names: Similarity
messages: Belongs to the GCF family.

9823:CRYL1
gene id: 9823:CRYL1
uniprot id: Q8SQ26
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Cytoplasm
messages: Has high L-gulonate 3-dehydrogenase activity. It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate.
messages: Homodimer.
messages: Inhibited by malonate.

9823:DSG4
gene id: 9823:DSG4
uniprot id: A0A8D1AKA6
uniprot id: I3L5R5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9823:GSC
gene id: 9823:GSC
uniprot id: A0A4X1SFG0
names: Subcellular Location Annotation
messages: Nucleus

9823:NIF3L1
gene id: 9823:NIF3L1
uniprot id: A0A287ASH3
uniprot id: A0A287B238
uniprot id: A0A4X1VDM4
uniprot id: A0A8D1L8R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9823:ZNF24
gene id: 9823:ZNF24
uniprot id: A0A4X1VB65
uniprot id: I3LAF2
names: Subcellular Location Annotation
messages: Nucleus

9823:TMCO3
gene id: 9823:TMCO3
uniprot id: A0A480YU12
uniprot id: A0A4X1TWC5
uniprot id: F1RN34
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100623540
gene id: 9823:LOC100623540
uniprot id: A0A8D1S9I8
uniprot id: K7GP63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9823:USP4
gene id: 9823:USP4
uniprot id: A0A287AEJ8
uniprot id: A0A480T9G5
uniprot id: A0A4X1STE2
uniprot id: A0A4X1SVE6
uniprot id: A0A8D1D3P8
uniprot id: A0A8D1M141
uniprot id: A0A8D1WTZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9823:HPRT1
gene id: 9823:HPRT1
uniprot id: B0LXK8
uniprot id: Q45FY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.
messages: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
messages: Cytoplasm
messages: Homotetramer.

9823:SUZ12
gene id: 9823:SUZ12
uniprot id: A0A287A167
uniprot id: A0A4X1TGA6
uniprot id: A0A4X1TK80
uniprot id: F1RKV6
names: Similarity
messages: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.

9823:SHOX2
gene id: 9823:SHOX2
uniprot id: A0A4X1SHY9
uniprot id: A0A8D0PD01
uniprot id: I3L828
names: Subcellular Location Annotation
messages: Nucleus

9823:PON3
gene id: 9823:PON3
uniprot id: A0A4X1TVE8
uniprot id: Q195H3
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9823:ALG2
gene id: 9823:ALG2
uniprot id: A7E1U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

9823:FAM131C
gene id: 9823:FAM131C
uniprot id: A0A287BPY6
uniprot id: A0A8D0UGQ3
names: Similarity
messages: Belongs to the FAM131 family.

9823:MED26
gene id: 9823:MED26
uniprot id: A0A4X1UTB1
uniprot id: A0A8D1XDE7
uniprot id: F1S9W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 26 family.
messages: Nucleus

9823:VASN
gene id: 9823:VASN
uniprot id: A0A4X1VSA9
uniprot id: I3LS87
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:MFSD4B
gene id: 9823:MFSD4B
uniprot id: F1RZP2
names: Subcellular Location Annotation
messages: Membrane

9823:RPS6KA4
gene id: 9823:RPS6KA4
uniprot id: A0A480KP66
uniprot id: A0A480PKR2
uniprot id: A0A8D0VMQ8
uniprot id: A0A8D1EJM5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9823:INHBC
gene id: 9823:INHBC
uniprot id: A0A8D0JIV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9823:LOC110255197
gene id: 9823:LOC110255197
uniprot id: A0A4X1TZ66
uniprot id: A0A5G2RCH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SRP68
gene id: 9823:SRP68
uniprot id: A0A4X1UYD0
uniprot id: A0A5G2RD86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

9823:TMEM63B
gene id: 9823:TMEM63B
uniprot id: A0A8D2A5R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9823:MFAP2
gene id: 9823:MFAP2
uniprot id: A0A4X1W8I2
uniprot id: F1SUS0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:ATP5E
gene id: 9823:ATP5E
uniprot id: A0A4X1UTW2
uniprot id: A5GFX4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9823:FAM129A
gene id: 9823:FAM129A
uniprot id: A0A4X1TW79
uniprot id: K7GRN9
names: Similarity
messages: Belongs to the Niban family.

9823:PHLDA3
gene id: 9823:PHLDA3
uniprot id: A0A4X1SI48
uniprot id: A0A8W4FE92
names: Subcellular Location Annotation
messages: Cytoplasm

9823:MYH4
gene id: 9823:MYH4
uniprot id: Q9TV62
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-4 (MYO4).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9823:RPS8
gene id: 9823:RPS8
uniprot id: A0A4X1W9K0
uniprot id: F2Z5F5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

9823:MCEE
gene id: 9823:MCEE
uniprot id: A0A8D0QR09
uniprot id: A1XQS7
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9823:CFD
gene id: 9823:CFD
uniprot id: P51779
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity).
messages: Secreted

9823:THPO
gene id: 9823:THPO
uniprot id: A0A480TRA2
uniprot id: A0A8D0RVD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

9823:VPS29
gene id: 9823:VPS29
uniprot id: A0A4X1U1Z7
uniprot id: A0A4X1U202
uniprot id: A0A5G2QIE0
uniprot id: A0A8D0IXS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9823:JMJD1C
gene id: 9823:JMJD1C
uniprot id: A0A8D0V5P5
uniprot id: A0A8D2BH89
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9823:POLD1
gene id: 9823:POLD1
uniprot id: A0A480Y1A1
uniprot id: A0A8D1A5L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9823:GLI1
gene id: 9823:GLI1
uniprot id: A0A8D0JJA6
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9823:HAMP
gene id: 9823:HAMP
uniprot id: Q8MJ80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hepcidin family.
messages: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.
messages: Interacts with SLC40A1; this interaction promotes SLC40A1 rapid ubiquitination.
messages: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
messages: Secreted

9823:DUSP5
gene id: 9823:DUSP5
uniprot id: A0A287B2F2
uniprot id: A0A4X1TFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9823:FAM160B2
gene id: 9823:FAM160B2
uniprot id: F1RMC0
names: Similarity
messages: Belongs to the FHIP family.

9823:GHRHR
gene id: 9823:GHRHR
uniprot id: E5F1H3
uniprot id: P34999
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane
messages: Pituitary gland. Also detected in the lymphocytes and thymocytes.
messages: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

9823:AKT2
gene id: 9823:AKT2
uniprot id: A0A8D0Y1T1
uniprot id: G9BWQ2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9823:DDX18
gene id: 9823:DDX18
uniprot id: A0A4X1SNX3
uniprot id: A0A8D0LRH2
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9823:GJB7
gene id: 9823:GJB7
uniprot id: A0A287BK92
uniprot id: A0A8D1ID11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:MTCH1
gene id: 9823:MTCH1
uniprot id: A0A8D1Q830
uniprot id: F1RVS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:GRPR
gene id: 9823:GRPR
uniprot id: A0A4X1UXD7
uniprot id: K7GR81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:LOC100511466
gene id: 9823:LOC100511466
uniprot id: A0A4X1UNL6
uniprot id: F1S7V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:OGFOD1
gene id: 9823:OGFOD1
uniprot id: A0A480KCY2
uniprot id: A0A4X1UD43
names: Similarity
messages: Belongs to the TPA1 family.

9823:GCHFR
gene id: 9823:GCHFR
uniprot id: A0A4X1UVQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

9823:CHD8
gene id: 9823:CHD8
uniprot id: A0A481CXW3
uniprot id: A0A4X1UY74
uniprot id: A0A8D0J4L3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
messages: Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Sumoylated.

9823:VDR
gene id: 9823:VDR
uniprot id: A3RGC1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with the corepressor NCOR1. Interacts with SNW1. Interacts with IRX4, the interaction does not affect its transactivation activity (By similarity). Interacts with CRY1 (By similarity). Interacts with CRY2 in a ligand-dependent manner (By similarity).
messages: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity).
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9823:RPL26L1
gene id: 9823:RPL26L1
uniprot id: B7TJ03
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9823:TNPO1
gene id: 9823:TNPO1
uniprot id: A0A8D0IHY9
names: Subcellular Location Annotation
messages: Cytoplasm

9823:ACADSB
gene id: 9823:ACADSB
uniprot id: A0A4X1SFV4
uniprot id: F1SED0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9823:CUL5
gene id: 9823:CUL5
uniprot id: A0A4X1VMQ4
uniprot id: A0A4X1VNP2
uniprot id: A0A8D0JSD3
uniprot id: A0A8D1YGD9
names: Similarity
messages: Belongs to the cullin family.

9823:SFN
gene id: 9823:SFN
uniprot id: Q1W2G0
names: Similarity
messages: Belongs to the 14-3-3 family.

9823:LTB
gene id: 9823:LTB
uniprot id: A0A4X1VFT3
uniprot id: A5D9N6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:MFSD1
gene id: 9823:MFSD1
uniprot id: A0A8D1L3C4
uniprot id: I3LIQ5
names: Subcellular Location Annotation
messages: Membrane

9823:ANO3
gene id: 9823:ANO3
uniprot id: A0A4X1SZW6
uniprot id: A0A8D0M294
uniprot id: A0A8D0Y8M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9823:EMC3
gene id: 9823:EMC3
uniprot id: A0A4X1UUJ9
uniprot id: A0A8D0NDB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9823:DDX59
gene id: 9823:DDX59
uniprot id: A0A287BS13
uniprot id: A0A4X1SMN0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.

9823:AGO4
gene id: 9823:AGO4
uniprot id: D9YJ47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9823:RRP36
gene id: 9823:RRP36
uniprot id: A0A4X1VA52
uniprot id: A5GFR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

9823:LOC100525562
gene id: 9823:LOC100525562
uniprot id: A0A4X1SP46
uniprot id: A0A8D0M8V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FAM199X
gene id: 9823:FAM199X
uniprot id: A0A4X1W440
uniprot id: K7GS69
names: Similarity
messages: Belongs to the FAM199 family.

9823:PTCH1
gene id: 9823:PTCH1
uniprot id: A0A481CF31
uniprot id: A0A8D1UFT0
uniprot id: A0A8D1XLI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9823:SL44-1
gene id: 9823:SL44-1
uniprot id: Q95JC9
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acinar cells and secretory granules of the parotid gland.
messages: Secreted
messages: The parotid hormone stimulates dentinal fluid transport in teeth.

9823:XDH
gene id: 9823:XDH
uniprot id: R4HZ39
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Homodimer. Interacts with BTN1A1.
messages: Peroxisome

9823:ZFP36L1
gene id: 9823:ZFP36L1
uniprot id: A0A286ZLK6
uniprot id: A0A4X1U1G3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9823:IFN-ALPHA-1
gene id: 9823:IFN-ALPHA-1
uniprot id: A0A8D1CD39
uniprot id: Q304W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:UNC119
gene id: 9823:UNC119
uniprot id: A0A480LC89
uniprot id: A0A4X1TSA4
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9823:TRAM1L1
gene id: 9823:TRAM1L1
uniprot id: A0A4X1V588
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9823:LOC100511247
gene id: 9823:LOC100511247
uniprot id: A0A5G2RKQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FAM189A2
gene id: 9823:FAM189A2
uniprot id: A0A8D1VIY6
names: Similarity
messages: Belongs to the ENTREP family.

9823:CYP2C33
gene id: 9823:CYP2C33
uniprot id: Q8SQ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane
messages: Microsome membrane

9823:CAND1
gene id: 9823:CAND1
uniprot id: A0A480K0D5
uniprot id: A0A8D0WBN9
names: Similarity
messages: Belongs to the CAND family.

9823:XKR5
gene id: 9823:XKR5
uniprot id: A0A287BT87
uniprot id: A0A4X1VY56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9823:MAP2K2
gene id: 9823:MAP2K2
uniprot id: A0A4X1VTZ6
uniprot id: K7GPS0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:AGO2
gene id: 9823:AGO2
uniprot id: D9YJ45
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Hydroxylated. 4-hydroxylation appears to enhance protein stability but is not required for miRNA-binding or endonuclease activity.
messages: Interacts with DICER1 through its Piwi domain and with TARBP2 during assembly of the RNA-induced silencing complex (RISC). Together, DICER1, AGO2 and TARBP2 constitute the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC). Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Note however that the term RISC has also been used to describe the trimeric RLC/miRLC. The formation of RISC complexes containing siRNAs rather than miRNAs appears to occur independently of DICER1. Interacts with AGO1. Also interacts with DDB1, DDX5, DDX6, DDX20, DHX30, DHX36, DDX47, DHX9, ELAVL, FXR1, GEMIN4, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, PABPC1, PRMT5, P4HA1, P4HB, RBM4, SART3, TNRC6A, TNRC6B, UPF1 and YBX1. Interacts with the P-body components DCP1A and XRN1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with RBM4; the interaction is modulated under stress-induced conditions, occurs under both cell proliferation and differentiation conditions and in an RNA-and phosphorylation-independent manner. Interacts with LIMD1, WTIP and AJUBA. Interacts with TRIM71. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with APOBEC3A, APOBEC3C, APOBEC3F and APOBEC3H. Interacts with DICER1, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with FMR1. Interacts with ZFP36.
messages: Nucleus
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.
messages: The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH).

9823:PPP2R2A
gene id: 9823:PPP2R2A
uniprot id: A0A287BPB7
uniprot id: A0A4X1VCH2
uniprot id: A0A4X1VD60
uniprot id: A0A8D0T2B2
uniprot id: A0A8D0UYW4
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9823:LOC100510971
gene id: 9823:LOC100510971
uniprot id: A0A4X1V733
uniprot id: F1RHR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TAF11
gene id: 9823:TAF11
uniprot id: A0A4X1T4L5
uniprot id: A0A8D0PT27
uniprot id: A0A8D1JFP7
uniprot id: F1RZ14
names: Similarity
messages: Belongs to the TAF11 family.

9823:SETD3
gene id: 9823:SETD3
uniprot id: A0A4X1TJH9
uniprot id: A0A5K1UVT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm
messages: Interacts with MYOD1.

9823:SFRP2
gene id: 9823:SFRP2
uniprot id: A0A4X1STF2
uniprot id: F1RX31
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:KRT10
gene id: 9823:KRT10
uniprot id: I3LDS3
names: Similarity
messages: Belongs to the intermediate filament family.

9823:CXCL11
gene id: 9823:CXCL11
uniprot id: A0A4X1SX03
uniprot id: A0A8D1B9F1
uniprot id: B3GDY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9823:CAPN3
gene id: 9823:CAPN3
uniprot id: A0A287BSN0
uniprot id: A0A4X1V0D1
uniprot id: A0A4X1V1W9
uniprot id: A0A5G2QPB9
uniprot id: A0A8D0RVE7
uniprot id: A0A8D1RZV3
uniprot id: P43368
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by micromolar concentrations of calcium and inhibited by calpastatin.
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53.
messages: Cytoplasm
messages: Homodimer.
messages: Homodimer; via EF-hand domain 4. Interacts with TTN/titin. Interacts with CMYA5; this interaction, which results in CMYA5 proteolysis, may protect CAPN3 from autolysis. Interacts with SIMC1. Interacts with UTP25; the interaction is required for CAPN3 translocation to the nucleolus.
messages: Skeletal muscle.
messages: nucleolus

9823:TAP1
gene id: 9823:TAP1
uniprot id: Q1ACV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

9823:SNRPF
gene id: 9823:SNRPF
uniprot id: A0A4X1SJX5
uniprot id: A0A8D1CDT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9823:MED29
gene id: 9823:MED29
uniprot id: A0A4X1SY16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

9823:GSTA1
gene id: 9823:GSTA1
uniprot id: P51781
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Alpha family.
messages: Cytoplasm
messages: Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid.
messages: Homodimer or heterodimer of GSTA1 and GSTA2.

9823:GSTZ1
gene id: 9823:GSTZ1
uniprot id: A0A4X1T3R0
uniprot id: A0A4X1T652
uniprot id: A0A5G2R0R7
uniprot id: A0A8D0NRI7
uniprot id: A0A8D0T5V4
uniprot id: K7GQV5
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9823:NEU3
gene id: 9823:NEU3
uniprot id: A0A286ZR19
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9823:EPN3
gene id: 9823:EPN3
uniprot id: A0A480DGA7
uniprot id: A0A8D1A739
uniprot id: A0A8D1E1K3
uniprot id: F1RT98
names: Similarity
messages: Belongs to the epsin family.

9823:ERH
gene id: 9823:ERH
uniprot id: A0A8D1UEG1
uniprot id: F2Z5J5
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9823:GOSR1
gene id: 9823:GOSR1
uniprot id: A0A4X1U194
uniprot id: A0A8D0P3W6
uniprot id: A0A8D1PMT9
uniprot id: A0A8D1TUX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9823:WT1
gene id: 9823:WT1
uniprot id: A0A4X1SVX2
uniprot id: O62651
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. Starting from the N-terminus, the second zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine, 5-formylcytosine or 5-carboxylcytosine.
messages: Cytoplasm
messages: Expressed during kidney development.
messages: Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP, AMER1 and SRY. Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles. Interacts with U2AF2. Interacts with HNRNPU via the zinc-finger region. Interacts with CITED2. Interacts with RBM4 (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Partially edited.
messages: Presence of the KTS motif hinders interactions between DNA and zinc-finger 4.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
messages: nucleolus
messages: nucleoplasm

9823:RAD1
gene id: 9823:RAD1
uniprot id: A0A8D1L3E0
uniprot id: F1SND5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9823:BNIP1
gene id: 9823:BNIP1
uniprot id: A0A4X1UAX1
uniprot id: A0A8D1MSB2
names: Subcellular Location Annotation
messages: Membrane

9823:HYAL4
gene id: 9823:HYAL4
uniprot id: A0A4X1VWR1
uniprot id: F1SMK4
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9823:LGMN
gene id: 9823:LGMN
uniprot id: A0A287AW67
uniprot id: A0A4X1SMU4
names: Similarity
messages: Belongs to the peptidase C13 family.

9823:STAT5A
gene id: 9823:STAT5A
uniprot id: Q9TUZ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcription factor STAT family.
messages: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity).
messages: Cytoplasm
messages: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1 and SOCS7. Interacts with ERBB4 (By similarity). Interacts with EBF4.
messages: ISGylated.
messages: Nucleus
messages: Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity). Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (By similarity). Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at Tyr-699 (By similarity).

9823:ZSCAN10
gene id: 9823:ZSCAN10
uniprot id: I3LSX1
names: Subcellular Location Annotation
messages: Nucleus

9823:TRAF6
gene id: 9823:TRAF6
uniprot id: A7XUJ6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Cytoplasm
messages: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN (By similarity). Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (By similarity). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Participates also in the TCR signaling by ubiquitinating LAT (By similarity).
messages: Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK2, IRAK3, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Interacts with PELI2 and PELI3. Binds UBE2V1. Interacts with TAX1BP1; this interaction mediates deubiquitination of TRAF6 and inhibition of NF-kappa-B activation (By similarity). Interacts with ZNF675. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts with RBCK1. Interacts with LIMD1 (via LIM domains) (By similarity). Interacts with RSAD2/viperin (By similarity). Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain) (By similarity). Interacts with ZFAND5. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with AJUBA. Interacts with MAVS/IPS1. Interacts (via TRAF domains) with DYNC2I2 (via WD domains). Interacts with IFIT3 (via N-terminus). Interacts with TICAM2. Interacts with CARD14. Interacts with CD40 and MAP3K8; the interaction is required for ERK activation (By similarity). Interacts with TICAM1 and this interaction is enhanced in the presence of WDFY1. Interacts with TANK; this interaction increases in response to DNA damage. Interacts with USP…
messages: Lipid droplet
messages: Nucleus
messages: Polyubiquitinated on Lys-125 by TRAF3IP2; after cell stimulation with IL17A (By similarity). Polyubiquitinated; after cell stimulation with IL1B or TGFB. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form. Deubiquitinated by USP10 in a TANK-dependent manner, leading to the negative regulation of NF-kappa-B signaling upon DNA damage. LRRC19 induces 'Lys-63' ubiquitination (By similarity). Ubiquitinated at Lys-338 by the SCF(FBXL2) complex, leading to its degradation by the proteasome (By similarity).
messages: Sumoylated on Lys-125, Lys-143 and Lys-472 with SUMO1.
messages: The MATH/TRAF domain binds to receptor cytoplasmic domains.
messages: The coiled coil domain mediates homo- and hetero-oligomerization.
messages: cell cortex

9823:OLFML2B
gene id: 9823:OLFML2B
uniprot id: A0A8D0UDB4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:MEN1
gene id: 9823:MEN1
uniprot id: A0A8D0PSW0
uniprot id: A0A8D1I465
uniprot id: F1RQR2
names: Subcellular Location Annotation
messages: Nucleus

9823:MRPL3
gene id: 9823:MRPL3
uniprot id: A0A140UHW4
uniprot id: A0A8D0RF71
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9823:USP7
gene id: 9823:USP7
uniprot id: B6DT15
names: Similarity
messages: Belongs to the peptidase C19 family.

9823:JAG1
gene id: 9823:JAG1
uniprot id: A0A287A671
uniprot id: A0A8D0T5K0
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9823:AVPI1
gene id: 9823:AVPI1
uniprot id: A0A286ZYA1
uniprot id: A0A8D0MXE7
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9823:APEX2
gene id: 9823:APEX2
uniprot id: A0A4X1VET7
uniprot id: K7GNL1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9823:LOC100512977
gene id: 9823:LOC100512977
uniprot id: A0A8D0ZQ48
uniprot id: F1SV18
names: Similarity
messages: Belongs to the KDELC family.

9823:HDAC6
gene id: 9823:HDAC6
uniprot id: A0A287BPX4
uniprot id: A0A8D0XH36
uniprot id: A0A8D0XL49
uniprot id: I3LEZ7
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.

9823:ODAM
gene id: 9823:ODAM
uniprot id: Q003G9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODAM family.
messages: Cytoplasm
messages: Interacts (via C-terminus) with ARHGEF5.
messages: Nucleus
messages: O-glycosylated.
messages: Secreted
messages: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

9823:LOC100511681
gene id: 9823:LOC100511681
uniprot id: A0A4X1TZJ8
uniprot id: F1S5T6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100153406
gene id: 9823:LOC100153406
uniprot id: A0A287AUI0
uniprot id: A0A8D0K6C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LIMS1
gene id: 9823:LIMS1
uniprot id: A0A287BTD0
uniprot id: A0A4X1VUA5
uniprot id: A0A4X1VUA9
uniprot id: A0A5G2R6E0
uniprot id: A0A8D1M8F7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9823:GALR1
gene id: 9823:GALR1
uniprot id: A0A4X1U6F0
uniprot id: A0A8D2CEH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9823:NEMP1
gene id: 9823:NEMP1
uniprot id: A0A8D0Q2G1
uniprot id: A0A8D1W5H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9823:FAM76B
gene id: 9823:FAM76B
uniprot id: A0A4X1TWG2
uniprot id: F1STI7
names: Similarity
messages: Belongs to the FAM76 family.

9823:CFL1
gene id: 9823:CFL1
uniprot id: P10668
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the actin-binding proteins ADF family.
messages: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:6509022, PubMed:9078368). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:9078368). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity).
messages: Can bind G- and F-actin in a 1:1 ratio of cofilin to actin (PubMed:6509022, PubMed:9078368). It is a major component of intranuclear and cytoplasmic actin rods (PubMed:9078368). Interacts with the subcortical maternal complex (SCMC) via interaction with TLE6 and NLRP5 (By similarity). Interacts with C9orf72 (By similarity).
messages: Inactivated by phosphorylation on Ser-3 (PubMed:9078368). Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2 (By similarity).
messages: Nucleus matrix
messages: Widely distributed in various tissues.
messages: axon
messages: cytoskeleton
messages: growth cone
messages: lamellipodium
messages: lamellipodium membrane
messages: ruffle membrane

9823:KDELR1
gene id: 9823:KDELR1
uniprot id: A0A4X1W1X6
uniprot id: F2Z4Z3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:PTS
gene id: 9823:PTS
uniprot id: A0A4X1TBY4
uniprot id: F1SM93
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9823:SELENBP1
gene id: 9823:SELENBP1
uniprot id: A0A480R1K2
uniprot id: A0A8D0SVL5
uniprot id: A0A8D1SHN4
uniprot id: A0A8D1Z7M0
uniprot id: F1ST01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

9823:HPGD
gene id: 9823:HPGD
uniprot id: A0A4X1V850
uniprot id: D0G6X9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:LOC100513411
gene id: 9823:LOC100513411
uniprot id: A0A8D1ACZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:YARS
gene id: 9823:YARS
uniprot id: A0A8D0PIS1
uniprot id: I3L804
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Nucleus

9823:IL17F
gene id: 9823:IL17F
uniprot id: A0A4X1TI16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9823:CLPTM1
gene id: 9823:CLPTM1
uniprot id: A0A8D0W5V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9823:SEPT7
gene id: 9823:SEPT7
uniprot id: A0A173G6H5
uniprot id: A0A480VER8
uniprot id: A0A4X1W830
uniprot id: A0A8D0V1L1
uniprot id: A0A8D0VRQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium axoneme
messages: flagellum
messages: kinetochore
messages: spindle

9823:TSSK2
gene id: 9823:TSSK2
uniprot id: A0A4X1UQE5
uniprot id: F1RK79
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:BEST4
gene id: 9823:BEST4
uniprot id: A0A8D1NY70
uniprot id: F1S347
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9823:FGFR1OP2
gene id: 9823:FGFR1OP2
uniprot id: A0A4X1VJ49
uniprot id: A0A8D0SU03
uniprot id: A0A8D0SUU1
uniprot id: I3LNP7
names: Similarity
messages: Belongs to the SIKE family.

9823:LOC100736675
gene id: 9823:LOC100736675
uniprot id: A0A5G2QT77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CNPY2
gene id: 9823:CNPY2
uniprot id: A0A4X1W9B8
uniprot id: A0A8D0J5G7
names: Similarity
messages: Belongs to the canopy family.

9823:HBEGF
gene id: 9823:HBEGF
uniprot id: Q01580
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).
messages: Interacts with FBLN1. Interacts with EGFR and ERBB4 (By similarity).
messages: Macrophages, midbrain, cerebellum, hypothalamus, cerebral cortex, bulbourethral gland, lung, heart ventricle, kidney, skin, prostate, seminal vesicle, testis; at low levels in lymph node, thymus, spleen; not detected in pituitary, olfactory bulb, thyroid, duodenum, pancreas, liver, submaxillary gland.
messages: O-glycosylated.
messages: extracellular space

9823:TXN
gene id: 9823:TXN
uniprot id: H6TBN0
uniprot id: P82460
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the thioredoxin family.
messages: Cytoplasm
messages: Erythrocytes.
messages: Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (By similarity).
messages: In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins (By similarity).
messages: Nucleus
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).
messages: Secreted

9823:ATP8B2
gene id: 9823:ATP8B2
uniprot id: A0A480UHV2
uniprot id: A0A4X1W0F3
uniprot id: A0A8D0RFE3
uniprot id: I3LIK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9823:AMELX
gene id: 9823:AMELX
uniprot id: P45561
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: A number of other isoforms are produced by carboxy-terminal processing.
messages: Belongs to the amelogenin family.
messages: Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.
messages: extracellular matrix

9823:LOC100621121
gene id: 9823:LOC100621121
uniprot id: A0A4X1VS04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:SGTA
gene id: 9823:SGTA
uniprot id: A0A287A1V6
uniprot id: A0A4X1VS62
names: Similarity
messages: Belongs to the SGT family.

9823:MEIG1
gene id: 9823:MEIG1
uniprot id: A0A286ZWX5
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9823:GCNT4
gene id: 9823:GCNT4
uniprot id: A0A4X1SRH1
uniprot id: A0A8D0LHX2
uniprot id: A0A8D0QPT7
uniprot id: I3LAJ3
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9823:FAM131B
gene id: 9823:FAM131B
uniprot id: A0A480PUJ1
uniprot id: A0A4X1V0A8
names: Similarity
messages: Belongs to the FAM131 family.

9823:TMPRSS7
gene id: 9823:TMPRSS7
uniprot id: A0A5G2QNS7
uniprot id: A0A8D1IJE7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:NEURL2
gene id: 9823:NEURL2
uniprot id: A0A8D1NSU8
uniprot id: F1SC72
names: Subcellular Location Annotation
messages: Cytoplasm

9823:PUS3
gene id: 9823:PUS3
uniprot id: A0A8D1CTH4
uniprot id: F1S759
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9823:DDOST
gene id: 9823:DDOST
uniprot id: Q29381
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (By similarity). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with SMIM22 (By similarity).
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:11443278). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).

9823:HTR2B
gene id: 9823:HTR2B
uniprot id: A0A8D0QGK0
uniprot id: F1SMV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9823:VDAC3
gene id: 9823:VDAC3
uniprot id: Q29380
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). Involved in male fertility and sperm mitochondrial sheath formation (By similarity).
messages: Interacts with ARMC12 in a TBC1D21-dependent manner. Interacts with MISFA.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

9823:HOXA4
gene id: 9823:HOXA4
uniprot id: A0A4X1TUD9
uniprot id: F1SHT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:ACSM3
gene id: 9823:ACSM3
uniprot id: A0A8D0Z227
uniprot id: A0A8D1M2T8
uniprot id: F1RPB1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:ZFP36
gene id: 9823:ZFP36
uniprot id: A0A8D1VR22
uniprot id: D0VE66
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9823:CD63
gene id: 9823:CD63
uniprot id: A0A8D0RSP8
uniprot id: F1SPK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9823:PTH1R
gene id: 9823:PTH1R
uniprot id: A0A480JVN1
uniprot id: P50133
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:8688470). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer (By similarity).
messages: Membrane
messages: N-glycosylated.
messages: Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

9823:LRRC8E
gene id: 9823:LRRC8E
uniprot id: A0A287A0M3
uniprot id: A0A4X1VNY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9823:HGD
gene id: 9823:HGD
uniprot id: A0A8D0RFQ6
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9823:HSPB1
gene id: 9823:HSPB1
uniprot id: Q5S1U1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Homooligomer. Homodimer; becomes monomeric upon activation. Heterooligomer; with HSPB6. Associates with alpha- and beta-tubulin. Interacts with TGFB1I1. Interacts with CRYAB. Interacts with HSPB8. Interacts with HSPBAP1.
messages: Nucleus
messages: Phosphorylated upon exposure to protein kinase C activators and heat shock. Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement.
messages: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.
messages: spindle

9823:TAS2R41
gene id: 9823:TAS2R41
uniprot id: A0A8D1ZWS9
uniprot id: F1SSI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9823:C2H11orf49
gene id: 9823:C2H11orf49
uniprot id: A0A480UYS9
uniprot id: A0A4X1VTB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: cytoskeleton

9823:SELENOW
gene id: 9823:SELENOW
uniprot id: Q95KL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SelWTH family. Selenoprotein W subfamily.
messages: Cytoplasm
messages: Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.
messages: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

9823:CCNT1
gene id: 9823:CCNT1
uniprot id: A0A8D0II06
names: Similarity
messages: Belongs to the cyclin family.

9823:GGT5
gene id: 9823:GGT5
uniprot id: A0A8D1Y038
uniprot id: F1RLR8
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

9823:SEPT9
gene id: 9823:SEPT9
uniprot id: A0A8D0SDN0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9823:POLR2E
gene id: 9823:POLR2E
uniprot id: A0A4X1VTX4
uniprot id: I3LSI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

9823:ACAP3
gene id: 9823:ACAP3
uniprot id: A0A4X1W8Z5
uniprot id: F1RJG0
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9823:PSENEN
gene id: 9823:PSENEN
uniprot id: A0A4X1TJQ9
uniprot id: A0A8D0UV39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9823:MCOLN1
gene id: 9823:MCOLN1
uniprot id: F1SCJ4
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9823:BTD
gene id: 9823:BTD
uniprot id: A0A4X1UTQ3
uniprot id: F1RS82
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9823:HHIP
gene id: 9823:HHIP
uniprot id: A0A287BB49
uniprot id: A0A4X1VHN3
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:SCTR
gene id: 9823:SCTR
uniprot id: F1CK15
names: Subcellular Location Annotation
messages: Membrane

9823:AMY2
gene id: 9823:AMY2
uniprot id: P00690
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 1 Cl(-) ion per subunit.
messages: Binds to the sea anemone inhibitor helianthamide and magnificamide.
messages: The two forms of this enzyme, I and II, show very similar activities, molecular masses, and compositions and differ only in their isoelectric points. As no evidence for two variants were in the cDNA library of PubMed:10082956, it is most likely that isoform I (PPAI) and isoform II (PPAII) are two forms of the same protein.
messages: extracellular space

9823:IFNA1
gene id: 9823:IFNA1
uniprot id: A0A4X1WDE7
uniprot id: Q6VAB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:MLF1
gene id: 9823:MLF1
uniprot id: A0A4X1SID5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9823:PAQR7
gene id: 9823:PAQR7
uniprot id: Q865K8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Cell membrane
messages: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
messages: Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved in neurosteroid inhibition of apoptosis. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone.

9823:PREB
gene id: 9823:PREB
uniprot id: A0A8D1Y7C4
uniprot id: F1SED4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9823:LOC100737265
gene id: 9823:LOC100737265
uniprot id: A0A287BKM7
uniprot id: A0A4X1U4N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9823:ZNF496
gene id: 9823:ZNF496
uniprot id: A0A4X1TWT2
uniprot id: A0A5G2QNP2
names: Subcellular Location Annotation
messages: Nucleus

9823:ODF2
gene id: 9823:ODF2
uniprot id: D9IFC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9823:SCGB1A1
gene id: 9823:SCGB1A1
uniprot id: A0A4X1VM49
uniprot id: A0A8D1SJM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9823:NEIL3
gene id: 9823:NEIL3
uniprot id: A0A287BGY1
uniprot id: A0A4X1VX30
uniprot id: A0A8D0JDH2
uniprot id: F1RT18
names: Similarity
messages: Belongs to the FPG family.

9823:XRN2
gene id: 9823:XRN2
uniprot id: A0A4X1V3A4
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9823:ALG3
gene id: 9823:ALG3
uniprot id: A0A480M700
uniprot id: A0A4X1UMX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:FFAR2-L
gene id: 9823:FFAR2-L
uniprot id: A0A4X1TJQ4
uniprot id: M9NLC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:LOC100156967
gene id: 9823:LOC100156967
uniprot id: A0A4X1TPC0
uniprot id: F1SJ34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9823:CLEC5A
gene id: 9823:CLEC5A
uniprot id: Q9GLF3
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation when its activation leads to enhanced recruitment of inflammatory macrophages and neutrophils to the joints.
messages: Cell membrane
messages: Constitutively expressed in monocytes and macrophages.
messages: Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP (PubMed:11414735). Regulates inflammatory responses (By similarity).
messages: Monomer (By similarity). Homodimer (By similarity). The majority of CLEC5A is expressed as a monomeric form on macrophages (By similarity). Interacts with TYROBP/DAP12 (PubMed:11414735). The interaction with TYROBP is required for CLEC5 cell surface expression (PubMed:11414735). Interacts with HCST/DAP10 (By similarity). Forms a CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP (By similarity).
messages: N-glycosylated. Contains sialic acid residues.

9823:ST3GAL1
gene id: 9823:ST3GAL1
uniprot id: A0A4X1SP39
uniprot id: F1RRV7
uniprot id: Q02745
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:19820709, PubMed:8288606). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:19820709, PubMed:8288606). Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans (PubMed:19820709, PubMed:8288606). As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (By similarity). Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8288606). Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8288606) (By similarity).
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Secreted
messages: Seems to lack a 40 residues internal segment.
messages: The long isoform is abundant in salivary gland, liver, lung, and colon mucosa. Both long and short forms are detected in submaxillary salivary glands.
messages: The soluble form derives from the membrane form by proteolytic processing.
messages: trans-Golgi network membrane

9823:PARK7
gene id: 9823:PARK7
uniprot id: A0A8D0IT98
uniprot id: Q0R678
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9823:KCNMA1
gene id: 9823:KCNMA1
uniprot id: O18866
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Cell membrane
messages: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation (By similarity).
messages: Homotetramer; which constitutes the calcium-activated potassium channel. Interacts with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. Interacts with gamma subunits LRRC26, LRRC38, LRRC52 and LRRC55. Beta and gamma subunits are accessory, and modulate its activity. Interacts with RAB11B (By similarity).
messages: Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network (By similarity).
messages: Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity (By similarity).
messages: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity).
messages: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity).
messages: The S0 segment is essential for the modulation by the accessory beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4.
messages: The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
messages: The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensor regions required for activation of the channel.
messages: The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation (By similarity).
messages: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).
messages: The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel contains binding sites for Ca(2+) and Mg(2+).

9823:RPL23
gene id: 9823:RPL23
uniprot id: P62831
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9823:EIF3H
gene id: 9823:EIF3H
uniprot id: A0A4X1T8R1
uniprot id: A0A4X1T8R5
uniprot id: A0A8D0IV95
uniprot id: A0A8D0U884
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9823:C7H14orf1
gene id: 9823:C7H14orf1
uniprot id: A0A8D1JA86
uniprot id: A0A8D1ZJK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:CYP39A1
gene id: 9823:CYP39A1
uniprot id: A7KZR7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:DYNLT3
gene id: 9823:DYNLT3
uniprot id: A0A4X1VCQ2
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9823:LOC106505000
gene id: 9823:LOC106505000
uniprot id: A0A8D0K796
uniprot id: F1SAE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:TMEM55B
gene id: 9823:TMEM55B
uniprot id: A0A286ZUJ8
uniprot id: A0A8D0T2V7
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9823:NDUFB7
gene id: 9823:NDUFB7
uniprot id: A0A8D1DQL9
uniprot id: F1SCH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9823:KIT
gene id: 9823:KIT
uniprot id: Q2HWD6
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation. Phosphorylated tyrosine residues are important for interaction with specific binding partners (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3 catalytic subunit. Interacts (via phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC. Interacts with IL1RAP (independent of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).
messages: Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to determine which are directly phosphorylated by KIT under in vivo conditions.
messages: Present in an inactive conformation in the absence of bound ligand. KITLG/SCF binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Activity is down-regulated by PRKCA-mediated phosphorylation on serine residues (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity).
messages: Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation.

9823:PRKAR2A
gene id: 9823:PRKAR2A
uniprot id: A0A4X1T0V7
uniprot id: C1PIG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9823:PPP1R15B
gene id: 9823:PPP1R15B
uniprot id: A0A4X1UZ41
uniprot id: I3LIA2
names: Similarity
messages: Belongs to the PPP1R15 family.

9823:G6PD
gene id: 9823:G6PD
uniprot id: A0A8D1XCN2
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

9823:CAVIN3
gene id: 9823:CAVIN3
uniprot id: A0A8D0V8J8
uniprot id: F1RMM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9823:GRM1
gene id: 9823:GRM1
uniprot id: A0A4X1VP89
uniprot id: F1S737
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9823:P4HA1
gene id: 9823:P4HA1
uniprot id: A0A286ZUW5
uniprot id: A0A4X1T5S7
uniprot id: A0A4X1T726
uniprot id: A1X898
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9823:INPP5J
gene id: 9823:INPP5J
uniprot id: A0A8D1PZW0
uniprot id: F1RPC4
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9823:PGRMC1
gene id: 9823:PGRMC1
uniprot id: Q95250
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins.
messages: Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions. Interacts with FECH; the interaction results in decreased FECH activity (By similarity). Interacts with EGFR, CYP1A1 and CYP3A4; the interactions require PGRMC1 homodimerization (By similarity).
messages: Microsome membrane
messages: Mitochondrion outer membrane
messages: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
messages: Secreted
messages: Smooth endoplasmic reticulum membrane
messages: The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 106 and 130.

9823:STRA6
gene id: 9823:STRA6
uniprot id: A0A8D0SFA5
uniprot id: F1SIE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:CHRM4
gene id: 9823:CHRM4
uniprot id: A0A8D1G6W5
uniprot id: F1SIA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9823:CENPO
gene id: 9823:CENPO
uniprot id: A0A4X1TV58
uniprot id: A0A8W4FFC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

9823:FABP3
gene id: 9823:FABP3
uniprot id: E0AD19
uniprot id: O02772
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
messages: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

9823:PREPL
gene id: 9823:PREPL
uniprot id: A0A4X1SJF6
uniprot id: A0A4X1SK85
names: Similarity
messages: Belongs to the peptidase S9A family.

9823:SPTB
gene id: 9823:SPTB
uniprot id: A0A8D1ZJL1
names: Similarity
messages: Belongs to the spectrin family.

9823:MED11
gene id: 9823:MED11
uniprot id: A0A4X1UXV1
uniprot id: A0A8D0ZFW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:AREG
gene id: 9823:AREG
uniprot id: A0A8D1K132
uniprot id: Q9BDH4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ART4
gene id: 9823:ART4
uniprot id: A0A8D1A5N2
uniprot id: A0A8D1I2Z6
uniprot id: K7GM93
uniprot id: Q95KR5
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9823:FAM167B
gene id: 9823:FAM167B
uniprot id: A0A4X1VZD3
uniprot id: A0A8D0T6R8
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9823:ATG3
gene id: 9823:ATG3
uniprot id: A0A4X1STY4
uniprot id: A0A8D0IFU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG3 family.
messages: Cytoplasm

9823:SLC25A14
gene id: 9823:SLC25A14
uniprot id: A0A480R103
uniprot id: A0A4X1W9G1
uniprot id: A0A8D0TCZ3
uniprot id: A0A8D1KAH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:SCD
gene id: 9823:SCD
uniprot id: O02858
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane
messages: Expected to bind 2 Fe(2+) ions per subunit.
messages: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
messages: The histidine box domains are involved in binding the catalytic metal ions.

9823:XPO7
gene id: 9823:XPO7
uniprot id: A0A4X1VH76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9823:SYNGR1
gene id: 9823:SYNGR1
uniprot id: A0A4X1VUI9
uniprot id: I3LLM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9823:PMAP-23
gene id: 9823:PMAP-23
uniprot id: P49930
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Exerts antimicrobial activity against both Gram-positive and negative bacteria at concentrations of 2-16 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes.
messages: Secreted

9823:RAB11FIP4
gene id: 9823:RAB11FIP4
uniprot id: A0A287ALE5
uniprot id: A0A4X1TL09
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

9823:CRHR1
gene id: 9823:CRHR1
uniprot id: B8Q4Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
messages: Membrane

9823:RXRG
gene id: 9823:RXRG
uniprot id: A0A2C9F369
uniprot id: A0A4X1VIC3
uniprot id: D0G7E9
uniprot id: Q0GFF6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300.
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Interacts with RARA (By similarity).
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.
messages: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).

9823:MRPS18A
gene id: 9823:MRPS18A
uniprot id: A0A8D0LTY3
uniprot id: F1RRH6
names: Subcellular Location Annotation
messages: Mitochondrion

9823:RANGRF
gene id: 9823:RANGRF
uniprot id: A0A287AY47
uniprot id: A0A4X1V932
uniprot id: A0A8D1JM03
uniprot id: A0A8D2BPC9
names: Similarity
messages: Belongs to the MOG1 family.

9823:CSNK1A1
gene id: 9823:CSNK1A1
uniprot id: A0A287ASJ4
uniprot id: A0A480VY41
uniprot id: A0A4X1T6B8
uniprot id: A0A4X1T845
uniprot id: A0A8D0K789
uniprot id: A0A8D1DJ21
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:RFFL
gene id: 9823:RFFL
uniprot id: A0A287AUW8
uniprot id: A0A287B8W0
names: Subcellular Location Annotation
messages: Cell membrane

9823:ACVR1B
gene id: 9823:ACVR1B
uniprot id: A0A4X1WBY0
uniprot id: D3K5N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9823:SEPT5
gene id: 9823:SEPT5
uniprot id: A0A173G6H0
uniprot id: A0A480TPT3
uniprot id: A0A8D0Y398
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9823:SLC46A2
gene id: 9823:SLC46A2
uniprot id: A0A8D0TY53
uniprot id: F1SNA4
names: Subcellular Location Annotation
messages: Membrane

9823:RGMB
gene id: 9823:RGMB
uniprot id: A0A480X256
uniprot id: A0A4X1TK90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9823:GRAMD1B
gene id: 9823:GRAMD1B
uniprot id: A0A287BNV1
uniprot id: A0A8D1Y664
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:PTGER3
gene id: 9823:PTGER3
uniprot id: A0A4X1UAE7
uniprot id: A0A4X1UDA1
uniprot id: A0A8D0MGR0
uniprot id: A0A8D0MJ21
uniprot id: P50131
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via C-terminus) with MKLN1.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality.

9823:ATP6V1G1
gene id: 9823:ATP6V1G1
uniprot id: A0A4X1UZN2
uniprot id: A0A8D1CUN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9823:ELF4
gene id: 9823:ELF4
uniprot id: F1RTH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:TYRO3
gene id: 9823:TYRO3
uniprot id: A0A4X1UYK4
uniprot id: A0A4X1UYL1
uniprot id: F1SSV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

9823:MEAF6
gene id: 9823:MEAF6
uniprot id: A0A481C504
uniprot id: A0A8D1WVQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

9823:SDR16C5
gene id: 9823:SDR16C5
uniprot id: A0A4X1ST96
uniprot id: D3K5L0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:CTH
gene id: 9823:CTH
uniprot id: Q19QT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family.
messages: Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate. Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (By similarity). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity).
messages: Cytoplasm
messages: Homotetramer (By similarity). Interacts with CALM in a calcium-dependent manner (By similarity).

9823:TMCO1
gene id: 9823:TMCO1
uniprot id: C5HGF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum (ER) overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload. Component of the GET- and EMC-like (GEL) complex, composed of RAB5IF/OPTI and TMCO1. The GEL complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex.
messages: Widely expressed, with high levels in liver, kidney and heart, intermediate amounts in back fat, longissimus dorsi, brain, lymph, large intestine, small intestine and lung, and low levels in spleen and stomach.

9823:C9H1orf27
gene id: 9823:C9H1orf27
uniprot id: A0A480EIY3
uniprot id: A0A8D1SCM1
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

9823:CAPN2
gene id: 9823:CAPN2
uniprot id: A6YNL5
names: Similarity
messages: Belongs to the peptidase C2 family.

9823:MAPK1IP1L
gene id: 9823:MAPK1IP1L
uniprot id: A0A4X1WD38
uniprot id: A0A8D0VRK4
names: Similarity
messages: Belongs to the MISS family.

9823:PRELID3B
gene id: 9823:PRELID3B
uniprot id: A5GFX0
names: Similarity
messages: Belongs to the slowmo family.

9823:LOC100523913
gene id: 9823:LOC100523913
uniprot id: A0A4X1VH61
uniprot id: A0A8D1HW57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:DPYSL5
gene id: 9823:DPYSL5
uniprot id: A0A8D0SYS8
uniprot id: F1SDQ2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9823:ASPA
gene id: 9823:ASPA
uniprot id: B1PK17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus

9823:RSL24D1
gene id: 9823:RSL24D1
uniprot id: A0A4X1TDB3
uniprot id: A0A8D1LCL6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9823:AP4B1
gene id: 9823:AP4B1
uniprot id: A0A4X1SZR0
uniprot id: F1SBR2
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9823:RBM5
gene id: 9823:RBM5
uniprot id: A0A480DPP4
uniprot id: A0A4X1SMW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9823:EDEM2
gene id: 9823:EDEM2
uniprot id: A0A480QI21
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9823:MUL1
gene id: 9823:MUL1
uniprot id: A0A4X1W528
uniprot id: A0A8D1KX19
names: Subcellular Location Annotation
messages: Membrane

9823:PON1
gene id: 9823:PON1
uniprot id: A0A8D0JYK4
uniprot id: A4US67
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9823:LOC100513910
gene id: 9823:LOC100513910
uniprot id: A0A287A3R9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:AMCF-II
gene id: 9823:AMCF-II
uniprot id: P22952
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Alveolar macrophages.
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: By lipopolysaccharide (LPS).
messages: Has chemotactic activity for porcine, and in a lesser extent, for human neutrophils.
messages: Secreted

9823:TYW1
gene id: 9823:TYW1
uniprot id: A0A8D0SSZ8
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.

9823:LMOD2
gene id: 9823:LMOD2
uniprot id: A0A8D0XUX7
uniprot id: F1SLY4
names: Subcellular Location Annotation
messages: cytoskeleton

9823:SNU13
gene id: 9823:SNU13
uniprot id: A0A4X1W4V1
uniprot id: A0A8D0IT75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9823:HSPA1L
gene id: 9823:HSPA1L
uniprot id: A5A8V7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Interacts with PRKN.
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria.
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.

9823:GJC2
gene id: 9823:GJC2
uniprot id: A0A8D0PKZ2
uniprot id: A0A8D1CDA0
uniprot id: F1S5S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:BAZ1A
gene id: 9823:BAZ1A
uniprot id: A0A4X1T7N5
uniprot id: F1SHI5
names: Subcellular Location Annotation
messages: Nucleus

9823:GGCX
gene id: 9823:GGCX
uniprot id: A0A4X1W535
uniprot id: A0A5G2QEB8
names: Subcellular Location Annotation
messages: Membrane

9823:ARG2
gene id: 9823:ARG2
uniprot id: A0A8D0YYD8
uniprot id: A0A8D0Z0W9
uniprot id: F1SA26
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9823:HIST1H2BD
gene id: 9823:HIST1H2BD
uniprot id: A0A8D0X5U9
uniprot id: F2Z584
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:MMP14
gene id: 9823:MMP14
uniprot id: Q9XT90
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M10A family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis.
messages: Highly expressed in developing tooth tissues.
messages: Interacts (via C-terminal cytoplasmic tail) with BST2. Interacts with DLL1; inhibits DLL1-induced Notch signaling.
messages: Melanosome
messages: Membrane
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: Tyrosine phosphorylated by PKDCC/VLK.

9823:LOC100624150
gene id: 9823:LOC100624150
uniprot id: A0A287BHL8
uniprot id: A0A4X1U1T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TINAGL1
gene id: 9823:TINAGL1
uniprot id: A0A480Z722
uniprot id: A0A4X1VZS3
uniprot id: A0A8D1J6G4
names: Similarity
messages: Belongs to the peptidase C1 family.

9823:STAT6
gene id: 9823:STAT6
uniprot id: A0A4X1W175
uniprot id: E1U8C5
uniprot id: E5F1H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9823:SCD5
gene id: 9823:SCD5
uniprot id: A0A4X1TFD0
uniprot id: B0FPB3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9823:TMEM214
gene id: 9823:TMEM214
uniprot id: A0A480PUQ8
uniprot id: A0A8D1Y5W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:FGF9
gene id: 9823:FGF9
uniprot id: Q95L12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).
messages: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity).
messages: Secreted

9823:STRN
gene id: 9823:STRN
uniprot id: A0A287B6T0
uniprot id: A0A4X1T378
uniprot id: A0A4X1T4B2
uniprot id: F1S4P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9823:SLC16A12
gene id: 9823:SLC16A12
uniprot id: A0A8D1F5A9
uniprot id: F1SCX9
names: Subcellular Location Annotation
messages: Membrane

9823:MFGE8
gene id: 9823:MFGE8
uniprot id: B2CZF8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:SLC17A1
gene id: 9823:SLC17A1
uniprot id: A0A4X1VK03
uniprot id: Q7YQJ7
names: Subcellular Location Annotation
messages: Membrane

9823:SEMA6A
gene id: 9823:SEMA6A
uniprot id: A0A287AN44
uniprot id: A0A287B6K3
uniprot id: A0A4X1U8Q6
uniprot id: A0A8D0M9J4
uniprot id: A0A8D0MV68
uniprot id: A0A8D0MWM4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:PGAM1
gene id: 9823:PGAM1
uniprot id: A0A287AJQ2
uniprot id: A0A4X1UA74
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9823:TLE4
gene id: 9823:TLE4
uniprot id: A0A286ZQA3
uniprot id: A0A4X1VUV7
uniprot id: A0A4X1W1U4
uniprot id: A0A8D1GHS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9823:NFIX
gene id: 9823:NFIX
uniprot id: A0A287A966
uniprot id: A0A4X1T887
uniprot id: A0A8D0M7Q6
uniprot id: A0A8D0NN11
uniprot id: A0A8D1N8K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9823:CBR1
gene id: 9823:CBR1
uniprot id: I3RWJ1
uniprot id: Q28960
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Expressed in kidney (at protein level).
messages: Highly expressed in testis from newborns. After 30 days the levels are markedly decreased.
messages: Monomer.
messages: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha (PubMed:1377683, PubMed:1597188). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (By similarity).

9823:DYRK1B
gene id: 9823:DYRK1B
uniprot id: A0A8D0MB13
uniprot id: A0A8D0S5E1
uniprot id: A0A8D0YKI5
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9823:RAB33B
gene id: 9823:RAB33B
uniprot id: A0A4X1VH23
uniprot id: A0A8D1U6R1
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9823:EIF4EBP1
gene id: 9823:EIF4EBP1
uniprot id: A0A4X1VV86
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9823:HENMT1
gene id: 9823:HENMT1
uniprot id: A0A480TM63
uniprot id: A0A8D1ENA2
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9823:FITM1
gene id: 9823:FITM1
uniprot id: B2MVP8
uniprot id: B8XJY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol (By similarity).
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

9823:FAM161A
gene id: 9823:FAM161A
uniprot id: A0A287B6Q9
uniprot id: A0A8D0K631
uniprot id: A0A8D0KIU0
uniprot id: A0A8D1IQN2
names: Similarity
messages: Belongs to the FAM161 family.

9823:RETREG1
gene id: 9823:RETREG1
uniprot id: A0A480E929
uniprot id: A0A4X1TQI4
uniprot id: A0A8D0RGS3
uniprot id: A0A8D1VYE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:ANO10
gene id: 9823:ANO10
uniprot id: A0A8D1QV72
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:FOXO1
gene id: 9823:FOXO1
uniprot id: A4L7N3
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated. Acetylation at Lys-269 and Lys-281 are necessary for autophagic cell death induction. Deacetylated by SIRT2 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagic cell death. Once in the nucleus, acetylated by CREBBP/EP300. Acetylation diminishes the interaction with target DNA and attenuates the transcriptional activity. It increases the phosphorylation at Ser-263. Deacetylation by SIRT1 results in reactivation of the transcriptional activity. Oxidative stress by hydrogen peroxide treatment appears to promote deacetylation and uncoupling of insulin-induced phosphorylation. By contrast, resveratrol acts independently of acetylation. Acetylated at Lys-430, promoting its localization to the nucleus and transcription factor activity. Deacetylation at Lys-430 by SIRT6, promotes its translocation into the cytoplasm, preventing its transcription factor activity. Deacetylation and subsequent inhibition by SIRT6 has different effects depending on cell types: it inhibits gluconeogenesis in hepatocytes, promotes glucose sensing in pancreatic beta-cells and regulates lipid catabolism in brown adipocytes.
messages: Cytoplasm
messages: Highly in subcutaneous adipose and visceral adipose tissues. Levels higher in piglets than in adults. Also expressed at lower levels in liver and muscle.
messages: Interacts with LRPPRC. Interacts with RUNX2; the interaction inhibits RUNX2 transcriptional activity and mediates the IGF1/insulin-dependent BGLAP expression in osteoblasts Interacts with PPP2R1A; the interaction regulates the dephosphorylation of FOXO1 at Thr-24 and Ser-263 leading to its nuclear import. Interacts with NLK. Interacts with SIRT1; the interaction results in the deacetylation of FOXO1 leading to activation of FOXO1-mediated transcription of genes involved in DNA repair and stress resistance. Binds to CDK1. Interacts with the 14-3-3 proteins, YWHAG and YWHAZ; the interactions require insulin-stimulated phosphorylation on Thr-24, promote nuclear exit and loss of transcriptional activity. Interacts with SKP2; the interaction ubiquitinates FOXO1 leading to its proteasomal degradation. The interaction requires the presence of KRIT1. Interacts (via the C-terminal half) with ATF4 (via its DNA binding domain); the interaction occurs in osteoblasts, regulates glucose homeostasis via suppression of beta-cell proliferation and subsequent decrease in insulin production. Interacts with PRMT1; the interaction methylates FOXO1, prevents PKB/AKT1 phosphorylation and retains FOXO1 in the nucleus. Interacts with EP300 and CREBBP; the interactions acetylate FOXO1. Interacts with SIRT2; the interaction is disrupted in response to oxidative stress or serum deprivation, leading to increased level of acetylated FOXO1, which promotes stress-induced autophagy by stimulating E1-like activating enzyme ATG7. Interacts (acetylated form) with ATG7; the interaction is increased in response to oxidative stress or serum deprivation and promotes the autophagic process leading to cell death. Interacts (acetylated form) with PPARG. Interacts with XBP1; this interaction is direct and leads to FOXO1 ubiquitination and degradation via the proteasome pathway (By similarity). Interacts (via the Fork-head domain) with CEBPA; the interaction increases when FOXO1 is deacetylated. Interacts with…
messages: Methylation inhibits AKT1-mediated phosphorylation at Ser-263 and is increased by oxidative stress.
messages: Nucleus
messages: Phosphorylation by NLK promotes nuclear export and inhibits the transcriptional activity. In response to growth factors, phosphorylation on Thr-24, Ser-263 and Ser-326 by PKB/AKT1 promotes nuclear export and inactivation of transactivational activity. Phosphorylation on Thr-24 is required for binding 14-3-3 proteins. Phosphorylation of Ser-263 decreases DNA-binding activity and promotes the phosphorylation of Thr-24 and Ser-326, permitting phosphorylation of Ser-329 and Ser-332, probably by CDK1, leading to nuclear exclusion and loss of function. Stress signals, such as response to oxygen or nitric oxide, attenuate the PKB/AKT1-mediated phosphorylation leading to nuclear retention. Phosphorylation of Ser-336 is independent of IGF1 and leads to reduced function. Dephosphorylated on Thr-24 and Ser-263 by PP2A in beta-cells under oxidative stress leading to nuclear retention. Phosphorylation of Ser-256 by CDK1 disrupts binding of 14-3-3 proteins leading to nuclear accumulation and has no effect on DNA binding nor transcriptional activity. Phosphorylation by STK4/MST1 on Ser-219, upon oxidative stress, inhibits binding to 14-3-3 proteins and nuclear export (By similarity). PPIA/CYPA promotes its dephosphorylation on Ser-263 (By similarity).
messages: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:18293098). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (By similarity). Activity suppressed by insulin (By similarity). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (By similarity). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (By similarity). Promotes neural cell death (By similarity). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive…
messages: Ubiquitinated by SKP2. Ubiquitination leads to proteasomal degradation (By similarity).
messages: Up-regulated during preadipocyte differentiation. Down-regulated in these cells on treatment with IGF1.

9823:KCNN3
gene id: 9823:KCNN3
uniprot id: A0A480JK39
uniprot id: P58392
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.
messages: Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:11877319). Activation is followed by membrane hyperpolarization (PubMed:11877319). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (PubMed:11877319).
messages: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity). Interacts with CALM1 (By similarity).
messages: Inhibited by bee venom neurotoxin apamin.
messages: Membrane

9823:MLH1
gene id: 9823:MLH1
uniprot id: D3K5L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9823:SEBOX
gene id: 9823:SEBOX
uniprot id: A0A8D1JTE2
uniprot id: I3LKQ4
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100736663
gene id: 9823:LOC100736663
uniprot id: A0A4X1UYE2
uniprot id: F1SAN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NPTX1
gene id: 9823:NPTX1
uniprot id: A0A4X1UHZ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:SLC45A3
gene id: 9823:SLC45A3
uniprot id: A0A287AF62
uniprot id: A0A8D0QJ36
names: Subcellular Location Annotation
messages: Membrane

9823:HBZ
gene id: 9823:HBZ
uniprot id: A0A4X1UI72
uniprot id: F1RGX7
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

9823:ZSCAN20
gene id: 9823:ZSCAN20
uniprot id: A0A8D1BHJ2
uniprot id: F1SV80
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9823:PGK1
gene id: 9823:PGK1
uniprot id: Q7SIB7
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility.
messages: Cytoplasm
messages: Monomer.
messages: The sequence shown in PDB entry 1KF0 is a tentative sequence based on the electron density. It differs from that shown in 14 positions.

9823:NPY5R
gene id: 9823:NPY5R
uniprot id: O97969
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity).

9823:LOC100525232
gene id: 9823:LOC100525232
uniprot id: A0A8D1WSL5
uniprot id: F1S4A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane

9823:LOC100513978
gene id: 9823:LOC100513978
uniprot id: A0A4X1VQY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FTHL17
gene id: 9823:FTHL17
uniprot id: A0A8D0JSV7
uniprot id: A0A8D1VZ62
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9823:WNT9A
gene id: 9823:WNT9A
uniprot id: A0A4X1UJI2
uniprot id: I3LTN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:CPXM1
gene id: 9823:CPXM1
uniprot id: A0A480KGE1
uniprot id: A0A4X1SHD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9823:TMEM138
gene id: 9823:TMEM138
uniprot id: A0A480W4G0
uniprot id: A0A8D1QG78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9823:LOC100524517
gene id: 9823:LOC100524517
uniprot id: A0A8D1JBG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9823:CELA2A
gene id: 9823:CELA2A
uniprot id: P08419
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S1 family. Elastase subfamily.
messages: Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity.
messages: Interacts with CPA1. Interacts with SERPINA1.
messages: Pancreas.
messages: Secreted

9823:WDR82
gene id: 9823:WDR82
uniprot id: A0A4X1VQG0
uniprot id: A0A8D1YM05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9823:LOC100627283
gene id: 9823:LOC100627283
uniprot id: A0A8D1I843
uniprot id: I3LQU4
names: Subcellular Location Annotation
messages: Nucleus

9823:CXCL8
gene id: 9823:CXCL8
uniprot id: P26894
uniprot id: Q68CM2
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alveolar macrophages.
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: By lipopolysaccharide (LPS).
messages: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
messages: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
messages: Homodimer.
messages: Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.
messages: Secreted

9823:PSP-I
gene id: 9823:PSP-I
uniprot id: P35495
uniprot id: Q4R0H6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the spermadhesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer or heterodimer with PSP-II (depending on the type of glycosylation of PSP-I).
messages: Not yet identified, major porcine seminal plasma protein. Can bind soybean trypsin inhibitor after deglycosylation.
messages: Secreted
messages: Seminal plasma or sperm.

9823:LOC110255196
gene id: 9823:LOC110255196
uniprot id: A0A4X1TZD1
uniprot id: A0A8D1D0W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RNFT2
gene id: 9823:RNFT2
uniprot id: A0A4X1TS62
uniprot id: A0A8D1W3H8
names: Subcellular Location Annotation
messages: Membrane

9823:TPM4
gene id: 9823:TPM4
uniprot id: A0A8D0P6L0
uniprot id: A0A8D1NUQ4
uniprot id: D0G7F7
uniprot id: P67937
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.
messages: Expression is increased in smooth muscle cells during dedifferentiation from the contractile to the synthetic phenotype.
messages: Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

9823:TBX5
gene id: 9823:TBX5
uniprot id: A0A4X1TJK0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:NDUFS2
gene id: 9823:NDUFS2
uniprot id: A0A480JYS1
uniprot id: A0A4X1VKC6
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

9823:ABRA
gene id: 9823:ABRA
uniprot id: B5SNZ6
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
messages: Binds F-actin and ABLIM1, ABLIM2 and ABLIM3. Interaction with ABLIM2 and ABLIM3 enhances activity (By similarity).
messages: Expression increase gradually from 33 dpc (days post-coitum) to postnatal muscles, and peaks at 28 days postnatal.
messages: Specifically expressed in heart and skeletal muscles.
messages: The actin-binding domain 1 (ABD1) is intrinsically disordered, and binds to F-actin with higher affinity than ABD2.
messages: cytoskeleton
messages: sarcomere

9823:IMPAD1
gene id: 9823:IMPAD1
uniprot id: A0A480TJZ2
uniprot id: F1RT67
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily.
messages: Contains N-linked glycan resistant to endoglycosydase H.
messages: Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.
messages: Golgi apparatus
messages: Strongly inhibited by lithium.
messages: trans-Golgi network membrane

9823:APOM
gene id: 9823:APOM
uniprot id: Q2LE37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid (By similarity).
messages: Secreted

9823:FADD
gene id: 9823:FADD
uniprot id: A0A4X1SI57
uniprot id: Q56VC2
names: Function
messages: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

9823:CIRBP
gene id: 9823:CIRBP
uniprot id: A0A287A085
uniprot id: A0A287AK75
uniprot id: A0A4X1VTK6
uniprot id: A0A4X1VVR9
uniprot id: A0A8D0QMV5
uniprot id: F1S6R1
uniprot id: F5BHI3
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with EIF4G1. Associates with ribosomes.
messages: nucleoplasm

9823:IMPACT
gene id: 9823:IMPACT
uniprot id: A0A286ZRQ2
uniprot id: A0A480U399
uniprot id: A0A4X1VM00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

9823:EGFL8
gene id: 9823:EGFL8
uniprot id: A5A8Y8
uniprot id: B9TSS1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:LOC100512520
gene id: 9823:LOC100512520
uniprot id: A0A8D0IUP6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GRIK1
gene id: 9823:GRIK1
uniprot id: A0A286ZXH5
uniprot id: A0A480ZRX9
uniprot id: A0A4X1U9Z3
uniprot id: A0A8D0IEX9
uniprot id: A0A8D0ZAJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9823:CD1.1
gene id: 9823:CD1.1
uniprot id: Q9XS72
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
messages: Cell membrane
messages: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.
messages: Endosome membrane
messages: Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74 (By similarity).
messages: Membrane raft

9823:BRPF1
gene id: 9823:BRPF1
uniprot id: A0A8D0WZ96
uniprot id: A0A8D1EQ56
uniprot id: A0A8D1SJI1
uniprot id: A0A8D1VKT7
uniprot id: F1SQG0
names: Subcellular Location Annotation
messages: Nucleus

9823:SLC1A2
gene id: 9823:SLC1A2
uniprot id: A0A287AK79
uniprot id: A0A4X1SNF2
uniprot id: A0A8D0K951
uniprot id: A0A8D0KBA2
uniprot id: A0A8D0KDN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9823:SLC39A13
gene id: 9823:SLC39A13
uniprot id: A0A4X1VQF4
uniprot id: A0A8D0K0R0
names: Subcellular Location Annotation
messages: Membrane

9823:NUP188
gene id: 9823:NUP188
uniprot id: A0A480WX19
uniprot id: A0A4X1TP64
names: Subcellular Location Annotation
messages: nuclear pore complex

9823:ZBED9
gene id: 9823:ZBED9
uniprot id: A0A8D0V179
uniprot id: A0A8D1C467
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100156932
gene id: 9823:LOC100156932
uniprot id: A0A4X1VJL1
uniprot id: A0A8D1RZK9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:ABRAXAS2
gene id: 9823:ABRAXAS2
uniprot id: A0A4X1V7C1
uniprot id: A0A8D1MEN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abro1 subfamily.
messages: Nucleus
messages: spindle pole

9823:HEXIM2
gene id: 9823:HEXIM2
uniprot id: A0A8D1MNY0
uniprot id: F1RR20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9823:NKX6-3
gene id: 9823:NKX6-3
uniprot id: A0A287ARG6
uniprot id: A0A4X1U356
names: Subcellular Location Annotation
messages: Nucleus

9823:PHYKPL
gene id: 9823:PHYKPL
uniprot id: A0A287BCJ7
uniprot id: A0A4X1VWT8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9823:LOC733635
gene id: 9823:LOC733635
uniprot id: Q1KLB3
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9823:GATA4
gene id: 9823:GATA4
uniprot id: A0A480LG38
uniprot id: A0A8D0RFM0
uniprot id: A0A8D1K2Y5
uniprot id: I3LUZ9
uniprot id: Q8MIM5
names: Subcellular Location Annotation
messages: Nucleus

9823:PKD1
gene id: 9823:PKD1
uniprot id: F4NA29
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:GNMT
gene id: 9823:GNMT
uniprot id: A0A8Q9BVZ2
uniprot id: Q29555
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in liver.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.
messages: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate (PubMed:8281755). Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine (By similarity).
messages: Cytoplasm
messages: Homotetramer.
messages: Inhibited by 5-methyltetrahydrofolate monoglutamate and by 5-methyltetrahydrofolate pentaglutamate, inhibition is much more effective by the pentaglutamate form than by the monoglutamate form. Two molecules of 5-methyltetrahydrofolate are bound per tetramer. The binding sites are localized between subunits. Inhibitor binding may preclude movements of the polypeptide chain that are necessary for enzyme activity.

9823:BRINP3
gene id: 9823:BRINP3
uniprot id: A0A4X1TV71
uniprot id: A0A8D0VC83
names: Similarity
messages: Belongs to the BRINP family.

9823:CSNK2B
gene id: 9823:CSNK2B
uniprot id: B9TSQ8
uniprot id: P67872
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Casein kinase II/CK2 is a tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with DYNLT2 (By similarity). Interacts with CD163. Also a component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1 (By similarity). Interacts (via KSSR motif) with ARK2N. Interacts with JUN and ARK2N; mediates the interaction between ARK2N and JUN (By similarity).
messages: Nucleus
messages: Phosphorylated by alpha subunit. Also a component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation (By similarity).
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Participates in Wnt signaling.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.
messages: The KSSR motif is part of a protein interaction pocket that mediates interaction with cellular and viral proteins.

9823:TMEM231
gene id: 9823:TMEM231
uniprot id: A0A8D1L287
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

9823:ELF1
gene id: 9823:ELF1
uniprot id: A0A286ZTG6
uniprot id: A0A287A1F3
uniprot id: A0A8D1AHQ5
uniprot id: A0A8D1AJK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:SGCB
gene id: 9823:SGCB
uniprot id: B0FMQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

9823:GABARAP
gene id: 9823:GABARAP
uniprot id: A0A8D0MEA9
uniprot id: D7RA28
names: Similarity
messages: Belongs to the ATG8 family.

9823:SPPL2C
gene id: 9823:SPPL2C
uniprot id: F1RRS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9823:TSPAN4
gene id: 9823:TSPAN4
uniprot id: A0A4X1VZD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:VNN3
gene id: 9823:VNN3
uniprot id: A0A4X1V6L4
uniprot id: F1S3Q8
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9823:CNPY3
gene id: 9823:CNPY3
uniprot id: A5GFQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the canopy family.
messages: Endoplasmic reticulum
messages: Interacts with HSP90B1; this interaction is disrupted in the presence of ATP. Interacts with TLR1, TLR2, TLR4 and TLR9 (By similarity).
messages: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity).

9823:PGLYRP3
gene id: 9823:PGLYRP3
uniprot id: F8WK49
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9823:MID1IP1
gene id: 9823:MID1IP1
uniprot id: A0A4X1VGT7
uniprot id: F1RXQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9823:UGT1A6
gene id: 9823:UGT1A6
uniprot id: A0A481D317
uniprot id: A0A4X1TFL0
uniprot id: F1SM20
uniprot id: F1SM28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9823:SLA-8
gene id: 9823:SLA-8
uniprot id: Q6S7D1
names: Similarity
messages: Belongs to the MHC class I family.

9823:PRKACA
gene id: 9823:PRKACA
uniprot id: A0A4X1VAB5
uniprot id: A0A4X1VAC1
uniprot id: A0A8D1PDA4
uniprot id: F1SD45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Nucleus

9823:FBXO9
gene id: 9823:FBXO9
uniprot id: A0A4X1TFG6
uniprot id: F1S7C6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.

9823:PPP1CB
gene id: 9823:PPP1CB
uniprot id: P61292
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with African swine fever virus (ASFV) protein DP71L.
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress (By similarity).
messages: Nucleus
messages: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PPP1R7 and PPP1R12C. Interacts with PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with PPP1R12A and NUAK1; the interaction is direct. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824'. Interacts with FOXP3 (By similarity). Interacts with RRP1B (By similarity). Interacts with SERPINE1. Interacts with LZTR1 (By similarity).
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity).
messages: nucleolus
messages: nucleoplasm

9823:GON7
gene id: 9823:GON7
uniprot id: P0C8B5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 plays a supporting role to the catalytic subunit OSGEP in the complex.
messages: Nucleus

9823:DPEP1
gene id: 9823:DPEP1
uniprot id: A0A480I924
uniprot id: I3L719
uniprot id: P22412
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Hydrolyzes a wide range of dipeptides (PubMed:8045301, PubMed:8823187). Hydrolyzes the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (By similarity).
messages: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
messages: Inhibited by L-penicillamine (By similarity). Inhibited by cilastatin (PubMed:8823187, PubMed:8045301).
messages: Membrane
messages: microvillus membrane

9823:FABP5
gene id: 9823:FABP5
uniprot id: A0A8D0NB58
uniprot id: Q19KE2
uniprot id: Q2EN74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9823:CTSD
gene id: 9823:CTSD
uniprot id: Q4U1U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

9823:TGIF1
gene id: 9823:TGIF1
uniprot id: A0A4X1VR34
uniprot id: A0A4X1VSY9
uniprot id: A0A8D0HQR4
uniprot id: I3LKH3
names: Subcellular Location Annotation
messages: Nucleus

9823:ARID3C
gene id: 9823:ARID3C
uniprot id: A0A4X1UQK8
uniprot id: A0A8D1A7E3
uniprot id: F1SEC1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Transcription factor.

9823:TICAM1
gene id: 9823:TICAM1
uniprot id: A0A4X1VS73
uniprot id: K9J6H0
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.
messages: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
messages: Mitochondrion
messages: The N-terminal region is essential for activation of the IFNB promoter activity.
messages: autophagosome
messages: cytosol

9823:NPM2
gene id: 9823:NPM2
uniprot id: A0A4X1VH60
uniprot id: D3K5P0
names: Similarity
messages: Belongs to the nucleoplasmin family.

9823:ASRGL1
gene id: 9823:ASRGL1
uniprot id: A0A4X1VNE4
uniprot id: A0A8D1XME1
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

9823:RBBP8
gene id: 9823:RBBP8
uniprot id: A0A4X1VMH3
uniprot id: I3L8X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

9823:NR4A2
gene id: 9823:NR4A2
uniprot id: A0A287A395
uniprot id: A0A480VF89
uniprot id: A0A4X1VQG3
uniprot id: A0A4X1VR83
uniprot id: D7EZN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9823:LOC100157391
gene id: 9823:LOC100157391
uniprot id: A0A4X1VE54
uniprot id: A0A8D0IRK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9823:SERPINB9
gene id: 9823:SERPINB9
uniprot id: A0A4X1SSJ0
uniprot id: A0PA01
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9823:CROT
gene id: 9823:CROT
uniprot id: A0A287B7Y5
uniprot id: A0A8D0RF96
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9823:SLC39A14
gene id: 9823:SLC39A14
uniprot id: A0A480VPG4
uniprot id: A0A4X1VFS0
uniprot id: A0A4X1VGR6
uniprot id: A0A8W4FNC3
names: Subcellular Location Annotation
messages: Membrane

9823:FAM110B
gene id: 9823:FAM110B
uniprot id: A0A4X1SPY1
uniprot id: F1RT69
names: Similarity
messages: Belongs to the FAM110 family.

9823:DOLK
gene id: 9823:DOLK
uniprot id: A0A4X1TP87
uniprot id: A0A8D1SVK4
names: Similarity
messages: Belongs to the polyprenol kinase family.

9823:ACSL1
gene id: 9823:ACSL1
uniprot id: A0A287BMY7
uniprot id: A0A480QCC9
uniprot id: A0A4X1VRQ6
uniprot id: A0A4X1VWL0
uniprot id: Q6B339
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9823:CITED2
gene id: 9823:CITED2
uniprot id: A0A287A4Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9823:LOC100519023
gene id: 9823:LOC100519023
uniprot id: A0A8W4FF32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

9823:LOC100519009
gene id: 9823:LOC100519009
uniprot id: A0A5G2QUV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TCTEX1D4
gene id: 9823:TCTEX1D4
uniprot id: Q4VYA0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein light chain Tctex-type family.
messages: Cytoplasm
messages: Interacts with ENG/endoglin, TGFBR2 and TGFBR3. Interacts with PPP1CC.
messages: Nucleus
messages: acrosome
messages: cilium axoneme
messages: flagellum
messages: microtubule organizing center

9823:RETREG3
gene id: 9823:RETREG3
uniprot id: A0A287BPH4
uniprot id: A0A4X1U0B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:ACTN1
gene id: 9823:ACTN1
uniprot id: A0A480J3H1
names: Similarity
messages: Belongs to the alpha-actinin family.

9823:ZDHHC22
gene id: 9823:ZDHHC22
uniprot id: A0A4X1T7S0
uniprot id: A0A8D0TA83
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:MYOC
gene id: 9823:MYOC
uniprot id: A0A4X1UKQ6
uniprot id: Q8HZW2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:GPR37
gene id: 9823:GPR37
uniprot id: A0A4X1W174
uniprot id: A0A5G2R7J7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:MET
gene id: 9823:MET
uniprot id: Q2QLE0
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity. Interacts with tensin TNS3 (By similarity). Interacts (when phosphorylated) with tensin TNS4 (via SH2 domain); the interaction increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation (By similarity).
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Membrane
messages: O-mannosylation of IPT/TIG domains by TMEM260 is required for protein maturation. O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

9823:C2H11orf58
gene id: 9823:C2H11orf58
uniprot id: A0A4X1TFD3
uniprot id: A0A8D0HZ88
names: Similarity
messages: Belongs to the SMAP family.

9823:TMED1
gene id: 9823:TMED1
uniprot id: A0A287BCX9
uniprot id: A0A4X1VH53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9823:GNA14
gene id: 9823:GNA14
uniprot id: A0A8D0RCV5
uniprot id: A4L2Z4
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9823:GDF7
gene id: 9823:GDF7
uniprot id: I3LB35
names: Similarity
messages: Belongs to the TGF-beta family.

9823:CCT7
gene id: 9823:CCT7
uniprot id: A0A8D0PFF9
uniprot id: D0G0C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9823:ARL8B
gene id: 9823:ARL8B
uniprot id: A0A4X1V3X6
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: spindle

9823:NAAA
gene id: 9823:NAAA
uniprot id: A0A8D1BMU0
uniprot id: F1RYU7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9823:FAM162B
gene id: 9823:FAM162B
uniprot id: A0A4X1TCM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9823:PSMB1
gene id: 9823:PSMB1
uniprot id: A0A287BPP9
uniprot id: A0A4X1VSI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9823:GPX8
gene id: 9823:GPX8
uniprot id: A0A4X1SMQ0
uniprot id: A0A8D0MZI3
uniprot id: A0A8D1PS45
uniprot id: F1SLM7
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9823:RBM15B
gene id: 9823:RBM15B
uniprot id: A0A8D1JXD5
uniprot id: F1SIZ8
names: Similarity
messages: Belongs to the RRM Spen family.

9823:TMEM170A
gene id: 9823:TMEM170A
uniprot id: A0A4X1SX53
uniprot id: A0A8D0JM64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9823:SNAPIN
gene id: 9823:SNAPIN
uniprot id: A0A286ZUD5
uniprot id: A0A8D0R6V0
uniprot id: A0A8D0UKZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9823:SLC35E1
gene id: 9823:SLC35E1
uniprot id: A0A4X1UTC9
uniprot id: F1S9W2
names: Subcellular Location Annotation
messages: Membrane

9823:GATAD2A
gene id: 9823:GATAD2A
uniprot id: A0A480EGJ1
uniprot id: A0A4X1U279
names: Subcellular Location Annotation
messages: Nucleus

9823:LIPC
gene id: 9823:LIPC
uniprot id: B8XSI5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:ADCK5
gene id: 9823:ADCK5
uniprot id: A0A480T1R8
uniprot id: F1RSN7
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9823:IMPDH2
gene id: 9823:IMPDH2
uniprot id: A0A8D1LMP1
uniprot id: F1SKI5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9823:LOC102166306
gene id: 9823:LOC102166306
uniprot id: A0A287BB29
uniprot id: A0A287BP58
uniprot id: A0A8D0R2R5
uniprot id: A0A8D1KMX2
names: Subcellular Location Annotation
messages: Secreted

9823:AMOTL1
gene id: 9823:AMOTL1
uniprot id: A0A8D0ZEM4
uniprot id: A0A8D0ZL27
uniprot id: A0A8D1CSA2
uniprot id: A0A8D1Z2P4
uniprot id: A0A8D1Z2R7
names: Similarity
messages: Belongs to the angiomotin family.

9823:DRAM2
gene id: 9823:DRAM2
uniprot id: A0A8D1J6A4
uniprot id: F1S630
names: Subcellular Location Annotation
messages: Membrane

9823:IFN-ALPHA-13
gene id: 9823:IFN-ALPHA-13
uniprot id: A0A8D1PXM7
uniprot id: C8CKA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:GLI2
gene id: 9823:GLI2
uniprot id: A0A8D0QV02
uniprot id: F1RXX4
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9823:TPRG1L
gene id: 9823:TPRG1L
uniprot id: A0A4X1WA34
uniprot id: A0A5G2QRM0
uniprot id: A0A8D1ICL6
uniprot id: F1RJA8
names: Similarity
messages: Belongs to the TPRG1 family.

9823:LOC100154757
gene id: 9823:LOC100154757
uniprot id: A0A287BQD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PA2G4
gene id: 9823:PA2G4
uniprot id: A0A4X1W958
uniprot id: A0A8D0PKU8
names: Similarity
messages: Belongs to the peptidase M24 family.

9823:TBPL1
gene id: 9823:TBPL1
uniprot id: A0A4X1VE45
uniprot id: I3LRL0
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9823:LOC100622127
gene id: 9823:LOC100622127
uniprot id: A0A5G2QHE1
uniprot id: A0A8D0ZJM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MPC1
gene id: 9823:MPC1
uniprot id: A0A4X1VW07
uniprot id: A0A5G2REF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9823:LOC100153925
gene id: 9823:LOC100153925
uniprot id: A0A287AYE6
uniprot id: A0A8D0MQW1
uniprot id: A0A8D1F6T7
uniprot id: F1RK97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

9823:LOC100512910
gene id: 9823:LOC100512910
uniprot id: A0A4X1UYS6
uniprot id: A0A8D0TKH0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:YIF1B
gene id: 9823:YIF1B
uniprot id: A0A480QFX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9823:LOC100737106
gene id: 9823:LOC100737106
uniprot id: A0A4X1TBR5
uniprot id: A0A5G2QUS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100736710
gene id: 9823:LOC100736710
uniprot id: F1SQC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MLF2
gene id: 9823:MLF2
uniprot id: A0A4X1UTZ0
uniprot id: A0A8D0PIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9823:PPP1CA
gene id: 9823:PPP1CA
uniprot id: A0A4X1T6I4
uniprot id: Q2EHH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9823:CYP26A1
gene id: 9823:CYP26A1
uniprot id: A0A0H4IQJ4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:ILVBL
gene id: 9823:ILVBL
uniprot id: A0A480JQU4
uniprot id: A0A8D1LEU1
uniprot id: F1SAN6
names: Similarity
messages: Belongs to the TPP enzyme family.

9823:SLC17A5
gene id: 9823:SLC17A5
uniprot id: A0A287A8C8
uniprot id: A0A4X1TYZ0
uniprot id: A0A4X1U1U6
uniprot id: A0A5K1UER8
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100737876
gene id: 9823:LOC100737876
uniprot id: A0A5G2QSN2
uniprot id: A0A8D0IUR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RPLP0
gene id: 9823:RPLP0
uniprot id: Q29214
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Cytoplasm
messages: Nucleus
messages: P0 forms a pentameric complex by interaction with dimers of P1 and P2. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APEX1. Interacts with FMR1.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
messages: Ubiquitinated at Lys-264 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).

9823:NRAS
gene id: 9823:NRAS
uniprot id: Q2MJK3
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP) (By similarity).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Interacts (active GTP-bound form preferentially) with RGS14. Interacts (active GTP-bound form) with RASSF7 (By similarity).
messages: Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
messages: Phosphorylation at Ser-89 by STK19 enhances NRAS-association with its downstream effectors.
messages: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
messages: Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.

9823:RIOX1
gene id: 9823:RIOX1
uniprot id: A0A287A2W8
uniprot id: A0A8D1N2Y9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.

9823:LOC100154044
gene id: 9823:LOC100154044
uniprot id: A0A287AW74
uniprot id: A0A8D1MN46
names: Similarity
messages: Belongs to the Bcl-2 family.

9823:TMEM151B
gene id: 9823:TMEM151B
uniprot id: A0A286ZL63
uniprot id: A0A4X1V5T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9823:ADPRHL1
gene id: 9823:ADPRHL1
uniprot id: A0A4X1U197
uniprot id: A0A8W4FD57
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9823:CPT2
gene id: 9823:CPT2
uniprot id: D5LIE7
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9823:TUBA8
gene id: 9823:TUBA8
uniprot id: A0A287BMB7
uniprot id: A0A8D0LLL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9823:CMC4
gene id: 9823:CMC4
uniprot id: A0A4X1T8D6
uniprot id: A0A8D0HYP0
names: Similarity
messages: Belongs to the CMC4 family.

9823:CDS2
gene id: 9823:CDS2
uniprot id: A0A4X1UHZ2
uniprot id: D0G6R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9823:EMC6
gene id: 9823:EMC6
uniprot id: A0A4X1UAQ2
uniprot id: A0A8W4F845
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LOC100624788
gene id: 9823:LOC100624788
uniprot id: A0A8D0RBI2
uniprot id: A0A8D0RC72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9823:ACSL5
gene id: 9823:ACSL5
uniprot id: D3K5K4
uniprot id: F1S5J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9823:ZNF280D
gene id: 9823:ZNF280D
uniprot id: A0A480JVE2
uniprot id: A0A4X1TJC6
uniprot id: I3LEU1
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9823:IL17A
gene id: 9823:IL17A
uniprot id: Q60I29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IL-17 family.
messages: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines. In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells. Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance. Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation. Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis. As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutroph…
messages: Highly expressed in adult heart, skin, and intestinal tissues, such as jejunum and ileum.
messages: Homodimer. Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule. IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex. IL17A homodimer adopts an asymmetrical ternary structure with one IL17RA molecule, allowing for high affinity interactions of one IL17A monomer with one IL17RA molecule (via D1 and D2 domains), while disfavoring binding of a second IL17RA molecule on the other IL17A monomer. Heterodimer with IL17F. IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer. IL17RA and IL17RC chains cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes.
messages: Secreted

9823:ALOX15
gene id: 9823:ALOX15
uniprot id: A0A8D1LBM2
uniprot id: P16469
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Cell membrane
messages: Interacts with PEBP1; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lipid droplet
messages: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:8305485, PubMed:17493578, PubMed:18311922, PubMed:19324874). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:8305485, PubMed:17493578). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (By similarity). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome prolifer…
messages: The PLAT domain can bind calcium ions; this promotes association with membranes.
messages: cytosol

9823:ATP9A
gene id: 9823:ATP9A
uniprot id: A5GFS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9823:LOC100517731
gene id: 9823:LOC100517731
uniprot id: A0A4X1UK67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9823:EBF2
gene id: 9823:EBF2
uniprot id: A0A8D1QN77
uniprot id: F2Z510
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9823:LOC100626318
gene id: 9823:LOC100626318
uniprot id: A0A287A0V2
uniprot id: A0A4X1TWX6
names: Subcellular Location Annotation
messages: Membrane

9823:TUBA1B
gene id: 9823:TUBA1B
uniprot id: Q2XVP4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.
messages: Belongs to the tubulin family.
messages: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (By similarity). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).
messages: Dimer of alpha and beta chains (PubMed:7225365). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Nascent tubulin polypeptide interacts (via beta-tubulin MREC motif) with TTC5/STRAP; this interaction may result in tubulin mRNA-targeted degradation.
messages: Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.
messages: Nitration of Tyr-451 is irreversible and interferes with normal dynein intracellular distribution.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREC motif mediates interaction with TTC5/STRAP and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:7225365). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:7225365). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:7225365).
messages: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules. In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).
messages: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (MATCAP, VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.
messages: cytoskeleton

9823:HNF1B
gene id: 9823:HNF1B
uniprot id: Q03365
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HNF1 homeobox family.
messages: Binds DNA as a dimer. Can form homodimer or heterodimer with HNF1-alpha (By similarity). Interacts (via HNF-p1 domain) with PCBD1; the interaction increases its transactivation activity (By similarity).
messages: Nucleus
messages: Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:8388098). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (PubMed:8388098). Transcriptional activity is increased by coactivator PCBD1 (By similarity).

9823:GFAP
gene id: 9823:GFAP
uniprot id: A0A480I7E4
uniprot id: A0A4X1TGK2
uniprot id: A0A4X1TID3
uniprot id: F1RR02
names: Similarity
messages: Belongs to the intermediate filament family.

9823:TERF2
gene id: 9823:TERF2
uniprot id: A0A8D1CYM6
uniprot id: F1S2L2
names: Subcellular Location Annotation
messages: telomere

9823:OLFML3
gene id: 9823:OLFML3
uniprot id: A0A8D0XDH6
uniprot id: H6UWK6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ARL1
gene id: 9823:ARL1
uniprot id: A0A8D1JID7
uniprot id: Q52NJ5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9823:CTSH
gene id: 9823:CTSH
uniprot id: B2D1T2
uniprot id: O46427
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Composed of cathepsin H and mini chain; disulfide-linked. Cathepsin H may be split into heavy and light chain. All chains are held together by disulfide bonds.
messages: Important for the overall degradation of proteins in lysosomes.
messages: Lysosome

9823:LOC100516283
gene id: 9823:LOC100516283
uniprot id: A0A8W4FI00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MAPK8IP1
gene id: 9823:MAPK8IP1
uniprot id: A0A287AQ99
uniprot id: A0A480NW77
uniprot id: A0A8D1J6A6
uniprot id: A0A8D2A5X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JIP scaffold family.
messages: Cytoplasm

9823:CRABP2
gene id: 9823:CRABP2
uniprot id: C6YXH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9823:RAD21
gene id: 9823:RAD21
uniprot id: A0A8D1ZWK3
uniprot id: F1S1K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9823:LOC100738112
gene id: 9823:LOC100738112
uniprot id: A0A8D1QGR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:IFN-OMEGA-2
gene id: 9823:IFN-OMEGA-2
uniprot id: C8CKC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:KRT4
gene id: 9823:KRT4
uniprot id: A0A8D1ZQ85
names: Similarity
messages: Belongs to the intermediate filament family.

9823:SMAD4
gene id: 9823:SMAD4
uniprot id: A0A480EJV2
uniprot id: Q9GKQ9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dwarfin/SMAD family.
messages: Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity).
messages: Cytoplasm
messages: Monomer; in the absence of TGF-beta activation (By similarity). Heterotrimer; on TGF-beta activation (By similarity). Heterotrimer composed of two molecules of a C-terminally phosphorylated R-SMAD molecule, SMAD2 or SMAD3, and one molecule of SMAD4 to form the transcriptional active SMAD2/SMAD3-SMAD4 complex (By similarity). Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Found in a complex with SMAD1 and YY1. Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4. Interacts with ATF2, COPS5, DACH1, MSG1, SKI, STK11/LKB1, STK11IP and TRIM33. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with USP9X. Interacts with RBPMS. Interacts with WWTR1 (via coiled-coil domain). Interacts with CITED1 and CITED2. Interacts with PDPK1 (via PH domain). Interacts with VPS39; this interaction affects heterodimer formation with SMAD3, but not with SMAD2, and leads to inhibition of SMAD3-dependent transcription activation. Interactions with VPS39 and SMAD2 may be mutually exclusive. Interacts (via MH2 domain) with ZNF451 (via N-terminal zinc-finger domains) (By similarity). Interacts with ZC3H3. Interacts weakly with ZNF8. Interacts with NUP93 and IPO7; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling (By similarity). Interacts with CREB3L1, the interaction takes place upon TGFB1 induction and SMAD4 acts as CREB3L1 coactivator to induce the expression of genes involved in the assembly of collagen extracellular matrix (By similarity). Interacts with DLX1 (By similarity). Interacts with ZBTB7A; the interaction is direct and stimulated by TGFB1 (By similarity). Interacts with CREBBP; the recruitment of this transcriptional coactivator is negatively regulated by ZBTB7A (By similarity). Interacts with EP300; the interaction with this transcriptional coactivator is negatively regulated by ZBTB7A (By similarity).…
messages: Monoubiquitinated on Lys-519 by E3 ubiquitin-protein ligase TRIM33. Monoubiquitination hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination by USP9X restores its competence to mediate TGF-beta signaling (By similarity).
messages: Nucleus
messages: Phosphorylated by PDPK1.
messages: The MH1 domain is required for DNA binding.
messages: The MH2 domain is required for both homomeric and heteromeric interactions and for transcriptional regulation. Sufficient for nuclear import (By similarity).

9823:KIAA1191
gene id: 9823:KIAA1191
uniprot id: A0A4X1SLG4
uniprot id: A0A4X1SLI1
uniprot id: A0A8D0MZN9
uniprot id: A0A8D1ZJC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9823:PPP1R18
gene id: 9823:PPP1R18
uniprot id: Q767M0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with Protein phosphatase 1 (PP1).
messages: May target protein phosphatase 1 to F-actin cytoskeleton.
messages: cytoskeleton

9823:PTPN1
gene id: 9823:PTPN1
uniprot id: A5GHK9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9823:LOC100157987
gene id: 9823:LOC100157987
uniprot id: A0A4X1TM30
names: Subcellular Location Annotation
messages: Nucleus

9823:ATP5O
gene id: 9823:ATP5O
uniprot id: Q2EN81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane

9823:TDRD7
gene id: 9823:TDRD7
uniprot id: A0A480HIF7
uniprot id: A0A8D1KED1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
messages: Cytoplasm
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.

9823:DYRK1A
gene id: 9823:DYRK1A
uniprot id: A0A287AIV4
uniprot id: A0A4X1TR90
uniprot id: A0A8D1HIQ7
uniprot id: A0A8D1KML8
uniprot id: A0A8D1N0F3
uniprot id: A0A8D2CFX7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9823:BMPR1B
gene id: 9823:BMPR1B
uniprot id: A0A4X1UG64
uniprot id: Q95L23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9823:CEP70
gene id: 9823:CEP70
uniprot id: A0A480T6Y8
uniprot id: A0A4X1TD85
uniprot id: A0A4X1TDC5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

9823:EIF1
gene id: 9823:EIF1
uniprot id: A0A4X1U8Q2
uniprot id: F2Z553
names: Similarity
messages: Belongs to the SUI1 family.

9823:C2H19orf53
gene id: 9823:C2H19orf53
uniprot id: A0A8D1XAW6
uniprot id: F1SD77
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9823:VIP
gene id: 9823:VIP
uniprot id: A0A8D0QJX1
uniprot id: E0Y441
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9823:DPAGT1
gene id: 9823:DPAGT1
uniprot id: A0A8D0XE71
uniprot id: F1SAH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:GPR33
gene id: 9823:GPR33
uniprot id: A0A8D1W6X1
uniprot id: D8VER3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

9823:GPC1
gene id: 9823:GPC1
uniprot id: A0A8D1WUM4
uniprot id: F1SIQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9823:HTR2A
gene id: 9823:HTR2A
uniprot id: A0A8D1GKE2
uniprot id: P50129
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity).
messages: Interacts (via C-terminus) with MPDZ and PATJ. May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.
messages: Membrane
messages: Presynapse
messages: Synapse
messages: The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

9823:COQ5
gene id: 9823:COQ5
uniprot id: A0A4X1T6M2
uniprot id: F1RJK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9823:TPT1
gene id: 9823:TPT1
uniprot id: P61288
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCTP family.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with STEAP3 (By similarity). Interacts with TSC22D1; interaction results in the destabilization of TSC22D1 protein (By similarity).
messages: Involved in calcium binding and microtubule stabilization (By similarity). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (By similarity).

9823:DPH5
gene id: 9823:DPH5
uniprot id: A0A4X1TRW2
uniprot id: F1S569
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9823:TLR4
gene id: 9823:TLR4
uniprot id: A0A480K9W0
uniprot id: A0A8D0QJW4
uniprot id: A0A8D1GYP2
uniprot id: F1SMI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9823:TRUB1
gene id: 9823:TRUB1
uniprot id: A0A287AWV0
uniprot id: A0A8D1KPG9
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9823:GUF1
gene id: 9823:GUF1
uniprot id: A0A4X1UKG4
uniprot id: F1S3T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

9823:JPT1
gene id: 9823:JPT1
uniprot id: A0A8D2A4Y0
uniprot id: F1RVX2
uniprot id: I7L9G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9823:FAM3A
gene id: 9823:FAM3A
uniprot id: A0A8D1F0E2
uniprot id: A0A8D1F4G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9823:RPL39
gene id: 9823:RPL39
uniprot id: A0A8D1S9I8
uniprot id: K7GP63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9823:TPRG1
gene id: 9823:TPRG1
uniprot id: A0A4X1UEG7
uniprot id: A0A8D0QKV4
uniprot id: F1SFH6
names: Similarity
messages: Belongs to the TPRG1 family.

9823:SF3A3
gene id: 9823:SF3A3
uniprot id: A0A4X1VWI8
uniprot id: F1SV40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3A3 family.
messages: Nucleus

9823:IL12B
gene id: 9823:IL12B
uniprot id: Q28938
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Secreted

9823:SPX
gene id: 9823:SPX
uniprot id: A0A286ZRD5
uniprot id: A0A5G2RA88
uniprot id: A0A8D1FNL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

9823:EBPL
gene id: 9823:EBPL
uniprot id: A0A4X1SL82
uniprot id: F1RK22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:FAM219B
gene id: 9823:FAM219B
uniprot id: A0A4X1TP85
uniprot id: F1SJ31
names: Similarity
messages: Belongs to the FAM219 family.

9823:RPS11
gene id: 9823:RPS11
uniprot id: A0A4X1VTS2
uniprot id: F2Z4Y8
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9823:SEC61A1
gene id: 9823:SEC61A1
uniprot id: A0A287AYT7
uniprot id: A0A4X1TV07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:FMR1
gene id: 9823:FMR1
uniprot id: A0A4X1SVB5
uniprot id: A0A4X1SVS1
uniprot id: K7GQ00
uniprot id: K7GSF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Stress granule
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

9823:MTMR4
gene id: 9823:MTMR4
uniprot id: A0A4X1SM89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9823:THOP1
gene id: 9823:THOP1
uniprot id: P47788
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the metabolism of neuropeptides under 20 amino acid residues long (By similarity). Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (By similarity). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
messages: Monomer.
messages: Ubiquitous.

9823:KCNK13
gene id: 9823:KCNK13
uniprot id: A0A4X1SV13
uniprot id: F1SDA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9823:API5
gene id: 9823:API5
uniprot id: A0A4X1SJH7
uniprot id: A0A8D0QMN9
uniprot id: A0A8D1X055
uniprot id: F1SHH7
names: Similarity
messages: Belongs to the API5 family.

9823:TMEM192
gene id: 9823:TMEM192
uniprot id: A0A8D0MB47
uniprot id: A0A8D0USG2
uniprot id: A0A8D1H5D7
uniprot id: A0A8D1H5L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

9823:LOC100153886
gene id: 9823:LOC100153886
uniprot id: A0A4X1UQL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:EPHA3
gene id: 9823:EPHA3
uniprot id: A0A8D0R6D4
uniprot id: D3K5K5
names: Subcellular Location Annotation
messages: Membrane

9823:CDC42SE1
gene id: 9823:CDC42SE1
uniprot id: A0A4X1W1R4
uniprot id: A0A4X1W2X3
uniprot id: A0A8D1G4K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9823:POPDC3
gene id: 9823:POPDC3
uniprot id: B8Q0B5
names: Similarity
messages: Belongs to the popeye family.

9823:MAP3K7
gene id: 9823:MAP3K7
uniprot id: A0A8D0VQL7
uniprot id: B0LXP5
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9823:KAT5
gene id: 9823:KAT5
uniprot id: A0A287BIK4
uniprot id: A0A480KLF9
uniprot id: A0A4X1ULG1
uniprot id: A0A5G2QX77
uniprot id: A0A8D1FTB8
uniprot id: A0A8D1YRA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9823:BTG2
gene id: 9823:BTG2
uniprot id: A4UTQ1
names: Similarity
messages: Belongs to the BTG family.

9823:PIR
gene id: 9823:PIR
uniprot id: A0A8D0T7L7
uniprot id: K7GKW6
names: Similarity
messages: Belongs to the pirin family.

9823:CD59
gene id: 9823:CD59
uniprot id: O62680
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in all tissues tested (lung, testis liver, kidney, spleen, heart and skeletal muscle). Highest levels in lung and spleen, lowest levels in liver and skeletal muscle.
messages: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.

9823:SLA-DMA
gene id: 9823:SLA-DMA
uniprot id: A0A8D0V9I6
uniprot id: Q9BEA4
names: Similarity
messages: Belongs to the MHC class II family.

9823:PODXL
gene id: 9823:PODXL
uniprot id: F1SNF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the podocalyxin family.
messages: Cell membrane
messages: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
messages: Membrane
messages: Membrane raft
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

9823:LOC100525933
gene id: 9823:LOC100525933
uniprot id: A0A8D0YZQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9823:KAT6B
gene id: 9823:KAT6B
uniprot id: A0A286ZID3
uniprot id: A0A287AGG6
uniprot id: A0A8D0X009
uniprot id: A0A8D1ST71
uniprot id: A0A8D1X774
uniprot id: F1S2G4
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

9823:TBL1XR1
gene id: 9823:TBL1XR1
uniprot id: A0A4X1V1Q3
uniprot id: A0A8D1GKS3
names: Similarity
messages: Belongs to the WD repeat EBI family.

9823:IFN-ALPHA-5
gene id: 9823:IFN-ALPHA-5
uniprot id: C8CK96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:IL11RA
gene id: 9823:IL11RA
uniprot id: A0A4X1USE8
uniprot id: A0A8D0JNP2
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9823:BROX
gene id: 9823:BROX
uniprot id: A0A4X1THH2
uniprot id: A0A8D1IJ12
names: Similarity
messages: Belongs to the BROX family.

9823:SLC23A2
gene id: 9823:SLC23A2
uniprot id: O97576
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9823:SAMHD1
gene id: 9823:SAMHD1
uniprot id: A0A023VTS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

9823:FOXR1
gene id: 9823:FOXR1
uniprot id: A0A8D0YN35
uniprot id: A0A8D1RVB7
names: Subcellular Location Annotation
messages: Nucleus

9823:TMLHE
gene id: 9823:TMLHE
uniprot id: A0A8D1NRB2
uniprot id: F1RZS1
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

9823:CDK7
gene id: 9823:CDK7
uniprot id: A0A8D1CTU4
uniprot id: C9K505
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9823:AIF1
gene id: 9823:AIF1
uniprot id: A0A4X1VFT5
uniprot id: A0A8D1Y7B3
uniprot id: A5D9N3
uniprot id: Q9GK84
names: Subcellular Location Annotation
messages: ruffle membrane

9823:TAX1BP3
gene id: 9823:TAX1BP3
uniprot id: A0A8D0JTM9
uniprot id: M3TYU2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9823:LOC100522337
gene id: 9823:LOC100522337
uniprot id: A0A8D0J005
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SERPIND1
gene id: 9823:SERPIND1
uniprot id: A0A481BLI9
uniprot id: A0A4X1UYS0
names: Similarity
messages: Belongs to the serpin family.

9823:UBE2D4
gene id: 9823:UBE2D4
uniprot id: A0A5G2RMT5
uniprot id: A0A8D0X3Q0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:OSGEPL1
gene id: 9823:OSGEPL1
uniprot id: F1RXU6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Mitochondrion
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9823:MPI
gene id: 9823:MPI
uniprot id: A0A8D1YPF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9823:WNT5A
gene id: 9823:WNT5A
uniprot id: A0A287A1J0
uniprot id: A0A4X1VKW8
uniprot id: A0A4X1VLY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:DICER1
gene id: 9823:DICER1
uniprot id: E2JE26
names: Function
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.
messages: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

9823:CPNE8
gene id: 9823:CPNE8
uniprot id: A0A8D0YRN2
uniprot id: I3LB11
names: Similarity
messages: Belongs to the copine family.

9823:HSPA9
gene id: 9823:HSPA9
uniprot id: A0A287ADJ2
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9823:MBTD1
gene id: 9823:MBTD1
uniprot id: A0A286ZRK9
uniprot id: A0A8D1P9Q3
uniprot id: A0A8D1RJB9
uniprot id: A0A8D1WA56
uniprot id: A0A8D2AAF9
names: Subcellular Location Annotation
messages: Nucleus

9823:CSN3
gene id: 9823:CSN3
uniprot id: P11841
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9823:IL6
gene id: 9823:IL6
uniprot id: A4D862
uniprot id: P26893
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
messages: Belongs to the IL-6 superfamily.
messages: Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.
messages: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
messages: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).
messages: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells.
messages: Secreted

9823:GIMAP6
gene id: 9823:GIMAP6
uniprot id: A0A8D0RWE0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9823:ST6GALNAC2
gene id: 9823:ST6GALNAC2
uniprot id: A0A4X1UXI0
uniprot id: F1RWP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9823:MIGA2
gene id: 9823:MIGA2
uniprot id: A0A8D1R099
uniprot id: A0A8D1YL47
names: Similarity
messages: Belongs to the mitoguardin family.

9823:BHMT2
gene id: 9823:BHMT2
uniprot id: E7D6R3
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9823:CASP3
gene id: 9823:CASP3
uniprot id: Q95ND5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Subunit p17 interacts with African swine fever virus (ASFV) inhibitor of apoptosis protein.
messages: Belongs to the peptidase C14A family.
messages: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.
messages: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity).
messages: S-nitrosylated on its catalytic site cysteine in unstimulated cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.

9823:ACBD5
gene id: 9823:ACBD5
uniprot id: A0A287BIS1
uniprot id: A0A8D1QX96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

9823:MS4A1
gene id: 9823:MS4A1
uniprot id: A0A8D0RYP2
uniprot id: A0A8D1EJN7
names: Similarity
messages: Belongs to the MS4A family.

9823:VAMP5
gene id: 9823:VAMP5
uniprot id: A0A4X1W7C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9823:LOC100520543
gene id: 9823:LOC100520543
uniprot id: A0A4X1UND0
uniprot id: A0A8D0M6S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NT5DC1
gene id: 9823:NT5DC1
uniprot id: A0A8D0VQB1
uniprot id: K7GPB8
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

9823:CASR
gene id: 9823:CASR
uniprot id: A0A480EVE4
uniprot id: A0A8D1ZVM4
uniprot id: L0HSA9
uniprot id: O62714
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (By similarity).
messages: Homodimer; disulfide-linked. Interacts with VCP and RNF19A (By similarity). Interacts with ARRB1 (By similarity).
messages: In resting state, adopts an open conformation, anion-binding promoting the inactive configuration (By similarity). Upon aromatic amino acid-binding, the groove in the extracellular venus flytrap module is closed, thereby inducing the formation of a novel homodimer interface between subunits (By similarity). Calcium ions stabilize the active state by enhancing homodimer interactions between membrane-proximal domains to fully activate the receptor (By similarity). In contrast to human protein, not activated by AMG 416, a D-amino acid-containing peptide agonist: this is probably due to the absence of a Cys residue at position 482, which forms a disulfide bond with the AMG 416 peptide agonist in human and that is replaced by a Tyr residue in pig (PubMed:26290606).
messages: Membrane
messages: N-glycosylated.
messages: The extracellular regions of the homodimer interact in a side-by-side fashion while facing opposite directions. Each extracellular region consists of three domains, LB1 (ligand-binding 1), LB2 and CR (cysteine-rich). The two lobe-shaped domains LB1 and LB2 form a venus flytrap module. In the inactive configuration, the venus flytrap modules of both protomers are in the open conformation associated with the resting state (open-open) and the interdomain cleft is empty. In addition, each protomer contains three anions, which reinforce the inactive conformation, and one calcium ion. In the active configuration, both protomers of extracellular regions have the closed conformation associated with agonist-binding (closed-closed). The ligand-binding cleft of each protomer is solely occupied by an aromatic amino-acid. Calcium is bound at four novel sites, including one at the homodimer interface. Agonist-binding induces large conformational changes within the extracellular region homodimer: first, the venus flytrap module of each protomer undergoes domain closure. Second, the LB2 regions of the two protomers approach each other, resulting in an expansion of the homodimer interactions involving LB2 domains. Third, the CR regions of the two subunits interact to form a large homodimer interface that is unique to the active state. The CR regions are brought into close contact by the motion involving LB2 since the two domains are rigidly associated within each subunit.
messages: Ubiquitinated by RNF19A; which induces proteasomal degradation.

9823:UXS1
gene id: 9823:UXS1
uniprot id: A0A480TRQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

9823:HMBOX1
gene id: 9823:HMBOX1
uniprot id: A0A4X1VB68
uniprot id: A0A8D0I1B5
uniprot id: A0A8D0RZA0
uniprot id: A0A8D1BW61
uniprot id: A0A8D1LML1
uniprot id: F1RJQ0
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100737025
gene id: 9823:LOC100737025
uniprot id: A0A5G2R190
uniprot id: A0A8D1IVX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:AUH
gene id: 9823:AUH
uniprot id: A0A4X1SE75
uniprot id: F1RN10
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9823:EPHB3
gene id: 9823:EPHB3
uniprot id: A0A8D0S116
uniprot id: A0A8D1CZD4
uniprot id: D3K5K6
uniprot id: F1SG86
names: Subcellular Location Annotation
messages: Membrane

9823:COPB1
gene id: 9823:COPB1
uniprot id: D2SW95
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Brefeldin A induces dissociation from the Golgi of the beta-COP and presumably the other coatomer subunits.
messages: COPI-coated vesicle membrane
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: High expression in the lung, kidney, skeletal muscle and small intestine, and lower level of expression in heart, liver, spleen, stomach and fat.
messages: Important candidate gene for meat quality and growth traits in animal breeding. May also be useful for the research of muscle development mechanisms.
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with CAPN8 and PRKCE. Interacts with SCYL1. Interacts with COPG1. Interacts with ARF1 (myristoylated); this interaction is required for binding of COPB1 to Golgi membranes. Interacts (via trunk domain) with ARF1 (via switch I region); the interaction is direct. Interacts with KCNK2 (via N-terminus); this interaction increases the channel-mediated whole cell currents and promotes plasma membrane expression of KCNK2. Interacts with STX17. Interacts with TMEM115 (By similarity). Interacts with TMEM41B (By similarity).
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis. Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1 (By similarity).

9823:PHYHIP
gene id: 9823:PHYHIP
uniprot id: A0A8D0JFU9
uniprot id: F1RMB1
names: Similarity
messages: Belongs to the PHYHIP family.

9823:ZKSCAN1
gene id: 9823:ZKSCAN1
uniprot id: A0A480JML4
uniprot id: A0A480Z539
uniprot id: A0A8D1SBJ8
names: Subcellular Location Annotation
messages: Nucleus

9823:DNMT1
gene id: 9823:DNMT1
uniprot id: Q4TTV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9823:AWN
gene id: 9823:AWN
uniprot id: P26776
uniprot id: Q4R0H8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: AWN proteins mediate the binding of boar spermatozoa to component(s) of the egg's zona pellucida by a carbohydrate-binding mechanism. Awn proteins are secretory components of the male accessory glands being coated to the sperm surface at the time of ejaculation. They possess as well heparin-, serine-protease-inhibitor-binding capability.
messages: Belongs to the spermadhesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Partial N-acetylation differentiates isoforms AWN-1 (not acetylated) and AWN-2 (acetylated).
messages: Secreted

9823:LOC100513523
gene id: 9823:LOC100513523
uniprot id: A0A8D1J1H9
uniprot id: F1S6L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NDUFS7
gene id: 9823:NDUFS7
uniprot id: A0A287B9B0
uniprot id: A0A4X1VVS8
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

9823:TNMD
gene id: 9823:TNMD
uniprot id: A5JHN8
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9823:NDST3
gene id: 9823:NDST3
uniprot id: F1S152
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9823:PIANP
gene id: 9823:PIANP
uniprot id: A0A4X1UXH6
uniprot id: F1SLT0
names: Subcellular Location Annotation
messages: Membrane

9823:CEBPB
gene id: 9823:CEBPB
uniprot id: A0A8D0SG50
uniprot id: E5Q8C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9823:PDE4A
gene id: 9823:PDE4A
uniprot id: A0A287AJ56
uniprot id: A0A287AZW9
uniprot id: A0A480KP45
uniprot id: A0A4X1V8C9
uniprot id: A0A4X1VAT4
uniprot id: A0A4X1VB41
uniprot id: Q684M5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9823:HNRNPH1
gene id: 9823:HNRNPH1
uniprot id: A0A4X1VVA1
uniprot id: A0A4X1VWG0
uniprot id: A0A4X1VXE2
uniprot id: A0A8D0Z5P7
uniprot id: A0A8D1Y762
uniprot id: A0A8D1YED5
names: Subcellular Location Annotation
messages: nucleoplasm

9823:SLC5A12
gene id: 9823:SLC5A12
uniprot id: A0A4X1SZJ0
uniprot id: F1SFZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9823:KCNN1
gene id: 9823:KCNN1
uniprot id: A0A287BKI2
uniprot id: A0A8D0S5X8
names: Subcellular Location Annotation
messages: Membrane

9823:B3GALT1
gene id: 9823:B3GALT1
uniprot id: A0A287B819
uniprot id: A0A8D1XQF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:ALDH3B1
gene id: 9823:ALDH3B1
uniprot id: A0A0K1TQQ2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9823:RAB34
gene id: 9823:RAB34
uniprot id: Q06AU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Interacts with RILP.
messages: Transport protein involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes (By similarity). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity).
messages: cilium
messages: phagosome
messages: phagosome membrane

9823:ZFX
gene id: 9823:ZFX
uniprot id: A0A287BQ77
uniprot id: A0A4X1VDH2
uniprot id: I3LL30
names: Subcellular Location Annotation
messages: Nucleus

9823:RIC8B
gene id: 9823:RIC8B
uniprot id: A0A286ZRA9
uniprot id: A0A4X1WD37
uniprot id: A0A8D0R9G6
uniprot id: A0A8D0UL28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9823:SIN3A
gene id: 9823:SIN3A
uniprot id: A0A8D0Z319
uniprot id: F1SJ69
names: Subcellular Location Annotation
messages: Nucleus

9823:DEFB114
gene id: 9823:DEFB114
uniprot id: A0A8D0I1I9
uniprot id: Q1RLJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:TP53BP2
gene id: 9823:TP53BP2
uniprot id: A0A286ZRX0
uniprot id: A0A8D1AJ12
uniprot id: F1S642
names: Subcellular Location Annotation
messages: Nucleus

9823:TPMT
gene id: 9823:TPMT
uniprot id: A0A480S0B0
uniprot id: A0A8D1QZ04
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Monomer.

9823:LOC100521938
gene id: 9823:LOC100521938
uniprot id: A0A8D0XTT0
uniprot id: F1SIM5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:ACP7
gene id: 9823:ACP7
uniprot id: A0A4X1SXF6
uniprot id: A0A8D0LVW1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

9823:RAB27B
gene id: 9823:RAB27B
uniprot id: A0A4X1UFY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9823:MS4A12
gene id: 9823:MS4A12
uniprot id: A0A8D1D195
names: Similarity
messages: Belongs to the MS4A family.

9823:PLK5
gene id: 9823:PLK5
uniprot id: A0A8D1DKX4
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9823:SLC9A2
gene id: 9823:SLC9A2
uniprot id: A7L5K8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9823:PDLIM3
gene id: 9823:PDLIM3
uniprot id: A0A4X1VW11
uniprot id: A0A8D0Y906
uniprot id: D3GGC5
uniprot id: Q6QGC0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ACTN2 (By similarity). Forms a heterodimer with PDLIM4 (via LIM domain) (By similarity).
messages: May play a role in the organization of actin filament arrays within muscle cells.
messages: Z line

9823:DNAJB12
gene id: 9823:DNAJB12
uniprot id: A0A8D0IPU6
uniprot id: A0A8D0IQ11
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LOC100623704
gene id: 9823:LOC100623704
uniprot id: A0A5G2R5V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CLIC6
gene id: 9823:CLIC6
uniprot id: A0A8D1I5J4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9823:DTD2
gene id: 9823:DTD2
uniprot id: A0A4X1T5K4
uniprot id: I3LU71
names: Similarity
messages: Belongs to the DTD family.

9823:DLX2
gene id: 9823:DLX2
uniprot id: A0A4X1V562
uniprot id: F1S082
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9823:TMEM45A
gene id: 9823:TMEM45A
uniprot id: A0A8D0QHM5
uniprot id: A0A8D2A0T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9823:IGF1R
gene id: 9823:IGF1R
uniprot id: A0A8D0IGG5
uniprot id: F1CK17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9823:DTD1
gene id: 9823:DTD1
uniprot id: A0A4X1V0N3
uniprot id: F1SBH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

9823:SOX3
gene id: 9823:SOX3
uniprot id: A0A8D0VFP9
uniprot id: I3LG51
names: Subcellular Location Annotation
messages: Nucleus

9823:RIPPLY1
gene id: 9823:RIPPLY1
uniprot id: A0A287BM90
uniprot id: A0A8D1BA19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9823:CFAP206
gene id: 9823:CFAP206
uniprot id: A0A286ZRB1
uniprot id: A0A8D0T0B2
uniprot id: A0A8D2CCU5
uniprot id: F1S0G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme

9823:IRF2BPL
gene id: 9823:IRF2BPL
uniprot id: A0A480TTF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9823:CEP63
gene id: 9823:CEP63
uniprot id: A0A480UUW8
uniprot id: A0A4X1TTT3
uniprot id: A0A4X1TU08
uniprot id: A0A8D1RDG5
names: Similarity
messages: Belongs to the CEP63 family.

9823:POT1
gene id: 9823:POT1
uniprot id: A0A287A5Z9
uniprot id: A0A8D0MUL6
uniprot id: B6DT13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9823:PANX2
gene id: 9823:PANX2
uniprot id: A0A4X1UP53
uniprot id: F1RXR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9823:CD99L2
gene id: 9823:CD99L2
uniprot id: A0A4X1SYL9
uniprot id: A0A8D0TD07
uniprot id: F1RQ20
names: Similarity
messages: Belongs to the CD99 family.

9823:DCK
gene id: 9823:DCK
uniprot id: A0A4X1TA10
uniprot id: F1RUN9
names: Similarity
messages: Belongs to the DCK/DGK family.

9823:MAPK1
gene id: 9823:MAPK1
uniprot id: E3UV40
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola
messages: focal adhesion

9823:RXRB
gene id: 9823:RXRB
uniprot id: A0A4X1UQM7
uniprot id: A0A8D0VA87
uniprot id: A5D9P3
uniprot id: F6PWE0
uniprot id: Q0GFF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9823:SELP
gene id: 9823:SELP
uniprot id: Q29097
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:MOSPD3
gene id: 9823:MOSPD3
uniprot id: A0A8D1HK30
uniprot id: D3K5I8
names: Subcellular Location Annotation
messages: Membrane

9823:HPCAL1
gene id: 9823:HPCAL1
uniprot id: Q06AT0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the recoverin family.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
messages: Membrane
messages: Probably binds two or three calcium ions.

9823:PNLIP
gene id: 9823:PNLIP
uniprot id: D4P6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9823:ZHX3
gene id: 9823:ZHX3
uniprot id: A0A287BCP2
uniprot id: A0A8D1RPA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9823:EDNRA
gene id: 9823:EDNRA
uniprot id: Q29010
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).

9823:SLC39A12
gene id: 9823:SLC39A12
uniprot id: A0A287AFC5
uniprot id: A0A287AX53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9823:RSPO2
gene id: 9823:RSPO2
uniprot id: A0A023M669
uniprot id: A0A4X1TFC1
names: Similarity
messages: Belongs to the R-spondin family.

9823:TXNRD1
gene id: 9823:TXNRD1
uniprot id: Q8HZQ4
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

9823:AGTPBP1
gene id: 9823:AGTPBP1
uniprot id: F1S4H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9823:GATA6
gene id: 9823:GATA6
uniprot id: A0A4X1VNF0
uniprot id: F1SBC0
uniprot id: Q95JA5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with LMCD1.
messages: Nucleus
messages: The GATA-type zinc fingers mediate interaction with LMCD1.
messages: Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions.

9823:ATP23
gene id: 9823:ATP23
uniprot id: A0A4X1VZJ5
uniprot id: F1SKD9
names: Similarity
messages: Belongs to the peptidase M76 family.

9823:LAMC1
gene id: 9823:LAMC1
uniprot id: A0A8D0REQ7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9823:CLK2
gene id: 9823:CLK2
uniprot id: A0A4X1VZF1
uniprot id: A0A8D0XEG5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:SLC27A1
gene id: 9823:SLC27A1
uniprot id: A0A4X1UC56
uniprot id: Q3HUX0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:PHTF2
gene id: 9823:PHTF2
uniprot id: A0A4X1SEH5
uniprot id: A0A8D2BRA3
names: Subcellular Location Annotation
messages: Membrane

9823:TYSND1
gene id: 9823:TYSND1
uniprot id: A0A8D0MJV2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

9823:ATP13A5
gene id: 9823:ATP13A5
uniprot id: A0A4X1UAS6
uniprot id: I3LUR3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:C6H1orf158
gene id: 9823:C6H1orf158
uniprot id: A0A4X1W7Z3
uniprot id: A0A8D1WB49
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

9823:AP2M1
gene id: 9823:AP2M1
uniprot id: A0A8D0WS89
uniprot id: A0A8D1DUB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: coated pit

9823:CD70
gene id: 9823:CD70
uniprot id: Q3ZDR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
messages: Homotrimer.
messages: Membrane
messages: N-glycosylated.

9823:UBLCP1
gene id: 9823:UBLCP1
uniprot id: A0A287BNL3
uniprot id: A0A8D0WM49
names: Subcellular Location Annotation
messages: Nucleus

9823:PAQR9
gene id: 9823:PAQR9
uniprot id: A0A8D0Z235
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:PON2
gene id: 9823:PON2
uniprot id: B1PK14
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9823:GPT2
gene id: 9823:GPT2
uniprot id: A0A287BGP0
uniprot id: A0A4X1TXF2
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9823:FAM163B
gene id: 9823:FAM163B
uniprot id: A0A4X1SY60
uniprot id: I3LTY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9823:RPS18
gene id: 9823:RPS18
uniprot id: P62272
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9823:DYDC2
gene id: 9823:DYDC2
uniprot id: A0A4X1SHP8
uniprot id: F1SEQ8
names: Similarity
messages: Belongs to the dpy-30 family.

9823:SCT
gene id: 9823:SCT
uniprot id: P63298
names: Function
names: Pharmaceutical
names: Similarity
names: Subcellular Location Annotation
messages: Available under the name Secretin-Ferring (Ferring Pharmaceuticals). Used for diagnostic use in pancreatic dysfunction.
messages: Belongs to the glucagon family.
messages: Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity).
messages: Secreted

9823:F2RL2
gene id: 9823:F2RL2
uniprot id: A0A480RZ72
uniprot id: A0A4X1SV60
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:SLC7A2
gene id: 9823:SLC7A2
uniprot id: A8I499
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Functions as permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine) (By similarity). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity).

9823:RPA1
gene id: 9823:RPA1
uniprot id: A0A480KQ60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

9823:DUPD1
gene id: 9823:DUPD1
uniprot id: A0A286ZIS3
uniprot id: A0A8D1S4C5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9823:XCL1
gene id: 9823:XCL1
uniprot id: B3VFB5
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Belongs to the intercrine gamma family.

9823:GAS6
gene id: 9823:GAS6
uniprot id: M1TFP4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:MESDC2
gene id: 9823:MESDC2
uniprot id: A0A4X1UQU5
uniprot id: F1RIE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

9823:TUB
gene id: 9823:TUB
uniprot id: A0A8D1K5X5
uniprot id: F1RNI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9823:XIRP1
gene id: 9823:XIRP1
uniprot id: B8LFE3
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9823:C8A
gene id: 9823:C8A
uniprot id: F1S788
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9823:PLEKHA8
gene id: 9823:PLEKHA8
uniprot id: A0A480MFC9
uniprot id: A0A8D0ZEJ3
names: Subcellular Location Annotation
messages: trans-Golgi network membrane

9823:GUCA2A
gene id: 9823:GUCA2A
uniprot id: P79897
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
messages: Secreted

9823:RNASE10
gene id: 9823:RNASE10
uniprot id: Q8SPJ0
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the pancreatic ribonuclease family.
messages: Male-specific expression in proximal caput of the epididymis.
messages: Represents 34% of the proteins secreted by the epididymis and 89% of the proteins secreted by the proximal caput.
messages: Secreted
messages: Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida (By similarity). Does not have ribonuclease activity.
messages: The N-terminus is blocked. Glycosylated.

9823:LOC100523717
gene id: 9823:LOC100523717
uniprot id: A0A4X1T653
uniprot id: A0A5G2R4S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SAMD8
gene id: 9823:SAMD8
uniprot id: A0A4X1SMU9
uniprot id: A0A8D0JMS3
uniprot id: A0A8D0TKI3
uniprot id: A0A8D1LVY2
uniprot id: F1S2F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9823:CCT8L2
gene id: 9823:CCT8L2
uniprot id: A0A4X1UM31
uniprot id: F1SSP4
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

9823:MAN2A2
gene id: 9823:MAN2A2
uniprot id: A0A8D0PX15
uniprot id: A0A8D0Q4L9
uniprot id: F1RMI9
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9823:PCMTD1
gene id: 9823:PCMTD1
uniprot id: A0A287BAK7
uniprot id: A0A4X1THL2
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9823:SULT2A1
gene id: 9823:SULT2A1
uniprot id: A0A8D1HJ03
uniprot id: Q3S3F7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:ABRACL
gene id: 9823:ABRACL
uniprot id: A0A4X1VHY8
names: Similarity
messages: Belongs to the costars family.

9823:HUS1
gene id: 9823:HUS1
uniprot id: A0A4X1U7V9
uniprot id: B6UV60
names: Similarity
messages: Belongs to the HUS1 family.

9823:ZDHHC9
gene id: 9823:ZDHHC9
uniprot id: A0A4X1W9J9
uniprot id: F1RTH7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:C9
gene id: 9823:C9
uniprot id: A0SEG9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:TGFB1
gene id: 9823:TGFB1
uniprot id: P07200
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction.
messages: Homodimer; disulfide-linked. Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling and the HTRA protease activity is required for this inhibition. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling. Interacts with CD109, DPT and ASPN. Interacts with EFEMP2. Interacts with TSKU; the interaction contributes to regulation of the hair cycle.
messages: Homodimer; disulfide-linked. Interacts with transforming growth factor beta-1 (TGF-beta-1) chain; interaction is non-covalent and maintains TGF-beta-1 in a latent state; each latency-associated peptide (LAP) monomer interacts with TGF-beta-1 in the other monomer. Interacts with LTBP1; leading to regulation of TGF-beta-1 activation. Interacts with LRRC32/GARP; leading to regulation of TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Interacts with LRRC33/NRROS; leading to regulation of TGF-beta-1 activation in macrophages and microglia. Interacts (via cell attachment site) with integrins ITGAV and ITGB6 (ITGAV:ITGB6), leading to release of the active TGF-beta-1. Interacts with NREP; the interaction results in a decrease in TGFB1 autoinduction. Interacts with HSP90AB1; inhibits latent TGFB1 activation.
messages: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1. Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules'. Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 ce…
messages: N-glycosylated. Deglycosylation leads to activation of Transforming growth factor beta-1 (TGF-beta-1); mechanisms triggering deglycosylation-driven activation of TGF-beta-1 are however unclear.
messages: PubMed:3166520 sequence which was said to originate from chicken. It however seems to originate from pig.
messages: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.
messages: Secreted
messages: The 'straitjacket' and 'arm' domains encircle the Transforming growth factor beta-1 (TGF-beta-1) monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104.
messages: The cell attachment site motif mediates binding to integrins (ITGAV:ITGB6 or ITGAV:ITGB8). The motif locates to a long loop in the arm domain called the bowtie tail. Integrin-binding stabilizes an alternative conformation of the bowtie tail (PubMed:21677751). Activation by integrin requires force application by the actin cytoskeleton, which is resisted by the 'milieu molecules' (such as LTBP1, LRRC32/GARP and/or LRRC33/NRROS), resulting in distortion of the prodomain and release of the active TGF-beta-1 (By similarity).
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.
messages: extracellular matrix

9823:GPKOW
gene id: 9823:GPKOW
uniprot id: A0A4X1SXY6
uniprot id: A0A8D1PKE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus
messages: RNA-binding protein involved in pre-mRNA splicing.

9823:ACOT6
gene id: 9823:ACOT6
uniprot id: A0A4X1TMR0
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9823:SCAND1
gene id: 9823:SCAND1
uniprot id: A0A4X1TDC3
uniprot id: F1S487
names: Subcellular Location Annotation
messages: Nucleus

9823:F2
gene id: 9823:F2
uniprot id: Q19AZ8
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Heterodimer (named alpha-thrombin) of a light and a heavy chain; disulfide-linked. Forms a heterodimer with SERPINA5. In plasma, interacts (via N-terminus) with alpha-1-microglobulin; this interaction does not prevent the activation of prothrombin to thrombin.
messages: In the penultimate step of the coagulation cascade, prothrombin is converted to thrombin by the prothrombinase complex composed of factor Xa (F10), cofactor Va (F5), and phospholipids. This activation requires factor Xa-catalyzed sequential cleavage at 2 sites, Arg-315 and Arg-364, along 2 possible pathways. In the first pathway, the first cleavage occurs at Arg-315, leading to the formation of the inactive intermediate prethrombin-2. This pathway preferentially occurs on platelets and in the absence of cofactor Va. In the second pathway, the first cleavage occurs at Arg-364, which separates protease domain into 2 chains that remain connected through a disulfide bond and generates the active intermediate meizothrombin. The presence of cofactor Va directs activation along the meizothrombin pathway and greatly accelerates the rate of cleavage at Arg-364, but has a smaller effect on the cleavage of meizothrombin at Arg-315. Meizothrombin accumulates as an intermediate when prothrombinase is assembled on the membrane of red blood cells.
messages: Inhibited by SERPINA5.
messages: The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin (By similarity).
messages: Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin, prior to its activation by factor Xa.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).

9823:ZNF445
gene id: 9823:ZNF445
uniprot id: A0A287BPX9
uniprot id: A0A4X1TGD5
names: Subcellular Location Annotation
messages: Nucleus

9823:GPI
gene id: 9823:GPI
uniprot id: A0A480S836
uniprot id: P08059
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI family.
messages: Cytoplasm
messages: Homodimer in the catalytically active form, monomer in the secreted form.
messages: ISGylated.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).
messages: Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.
messages: Secreted

9823:DKC1
gene id: 9823:DKC1
uniprot id: B7TJ11
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9823:A4GALT
gene id: 9823:A4GALT
uniprot id: A0A8D1KT09
uniprot id: I3L755
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9823:SF3B5
gene id: 9823:SF3B5
uniprot id: A0A4X1VPH8
uniprot id: A0A8W4F9Z6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9823:TES
gene id: 9823:TES
uniprot id: A0A480T0X9
uniprot id: Q2QLE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
messages: focal adhesion

9823:ZNF165
gene id: 9823:ZNF165
uniprot id: A0A481AL25
uniprot id: A0A4X1VJD3
names: Subcellular Location Annotation
messages: Nucleus

9823:DPPA5
gene id: 9823:DPPA5
uniprot id: A0A8D1ZBD4
uniprot id: C3U2T0
names: Similarity
messages: Belongs to the KHDC1 family.

9823:HTR7
gene id: 9823:HTR7
uniprot id: A0A8D0QU38
uniprot id: Q8SPH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:BMP5
gene id: 9823:BMP5
uniprot id: A0A059NTB8
uniprot id: A0A8D0T7U3
names: Similarity
messages: Belongs to the TGF-beta family.

9823:CSTF2T
gene id: 9823:CSTF2T
uniprot id: A0A4X1V914
uniprot id: F1SD01
names: Subcellular Location Annotation
messages: Nucleus

9823:NPM1
gene id: 9823:NPM1
uniprot id: A0A4X1U7Y6
uniprot id: I3LUP6
names: Similarity
messages: Belongs to the nucleoplasmin family.

9823:LOC100624700
gene id: 9823:LOC100624700
uniprot id: A0A8D1D084
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9823:ARF1
gene id: 9823:ARF1
uniprot id: A0A8D1SS99
uniprot id: C4MXZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9823:HP
gene id: 9823:HP
uniprot id: Q8SPS7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.
messages: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
messages: Belongs to the peptidase S1 family.
messages: Expressed by the liver and secreted in plasma.
messages: Secreted
messages: Tetramer of two alpha and two beta chains; disulfide-linked (By similarity). The hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers (PubMed:22922649). Interacts with CD163 (PubMed:22922649). Interacts with ERGIC3 (By similarity).
messages: The beta chain mediates most of the interactions with both subunits of hemoglobin, while the alpha chain forms the homodimeric interface.

9823:IFN-DELTA-11
gene id: 9823:IFN-DELTA-11
uniprot id: C8CKC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:SEPHS2
gene id: 9823:SEPHS2
uniprot id: A1YIZ1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.
messages: Truncated SEPHS2 proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC3) complex, which recognizes the glycine (Gly) at the C-terminus of truncated SEPHS2 proteins.

9823:LOC100523732
gene id: 9823:LOC100523732
uniprot id: A0A4X1U284
names: Subcellular Location Annotation
messages: Membrane

9823:GLMP
gene id: 9823:GLMP
uniprot id: A0A8D1IX48
uniprot id: A0A8D1PBE7
uniprot id: A0A8D2BVT7
uniprot id: F1RP16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9823:FYTTD1
gene id: 9823:FYTTD1
uniprot id: A0A4X1TLY8
uniprot id: A0A8D0IAD4
uniprot id: A0A8D1UF20
uniprot id: A0A8D1XL54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle
messages: nucleoplasm

9823:PQLC3
gene id: 9823:PQLC3
uniprot id: A0A4X1U8X0
uniprot id: F1SAA6
names: Subcellular Location Annotation
messages: Membrane

9823:PRMT5
gene id: 9823:PRMT5
uniprot id: A0A8D0I590
uniprot id: A0A8D0I970
uniprot id: A0A8D1ADD2
uniprot id: C3RZ98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9823:ABO
gene id: 9823:ABO
uniprot id: A0A8D0WW68
uniprot id: O77563
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

9823:C2H5orf63
gene id: 9823:C2H5orf63
uniprot id: A0A480YHT9
uniprot id: A0A4X1UF52
uniprot id: A0A4X1UHN7
uniprot id: F1RKL8
names: Similarity
messages: Belongs to the glutaredoxin family.

9823:BLOC1S3
gene id: 9823:BLOC1S3
uniprot id: A5A769
uniprot id: M3VK25
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S3 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (By similarity).
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).
messages: Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Interacts directly with BLOC1S2. Interacts with BLOC1S4, BLOC1S5 and BLOC1S6 (By similarity).
messages: Cytoplasm
messages: Phosphorylated.

9823:NOV
gene id: 9823:NOV
uniprot id: A0A481D0V4
uniprot id: A0A4X1T7A5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:GRAMD1C
gene id: 9823:GRAMD1C
uniprot id: A0A8D1Q4H3
uniprot id: A0A8D1XGN7
uniprot id: F1SP95
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:PAGE2B
gene id: 9823:PAGE2B
uniprot id: A0A4X1VJ82
uniprot id: D3K5J8
names: Similarity
messages: Belongs to the GAGE family.

9823:B3GNT2
gene id: 9823:B3GNT2
uniprot id: A0A8D1DVG2
uniprot id: F1SIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:TNC
gene id: 9823:TNC
uniprot id: Q29116
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tenascin family.
messages: By TGF-beta.
messages: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).
messages: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 (By similarity).
messages: N-glycosylated.
messages: Predominantly expressed in the embryonic and early postnatal stages. Little or no detection in adult brain.
messages: Submaxillary glands and brain.
messages: extracellular matrix

9823:ZIC3
gene id: 9823:ZIC3
uniprot id: A0A5G2R7X0
uniprot id: A0A8D0MZ67
uniprot id: A0A8D0WXB9
uniprot id: F1RQ88
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9823:GHRL
gene id: 9823:GHRL
uniprot id: G9M5P1
uniprot id: Q9GKY5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Amidation of Leu-99 is essential for obestatin activity.
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity).
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
messages: O-octanoylated by GOAT/MBOAT4 (By similarity). O-octanoylation is essential for ghrelin activity.
messages: O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
messages: Secreted

9823:USH1G
gene id: 9823:USH1G
uniprot id: A0A4X1SGT8
uniprot id: F1RVV1
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9823:ADRA1A
gene id: 9823:ADRA1A
uniprot id: A0A8D0THD9
uniprot id: A0A8D1I8I8
uniprot id: F6PTQ1
uniprot id: Q9TSW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9823:EGF
gene id: 9823:EGF
uniprot id: Q00968
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
messages: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (By similarity). Interacts with RHBDF2 (By similarity).
messages: Membrane

9823:SLC25A13
gene id: 9823:SLC25A13
uniprot id: A0A4X1TR24
uniprot id: A0A8D1VA14
uniprot id: M3VH80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9823:ABCB4
gene id: 9823:ABCB4
uniprot id: A0A286ZJ46
uniprot id: A0A8D1DCC9
names: Subcellular Location Annotation
messages: Membrane

9823:TP53INP2
gene id: 9823:TP53INP2
uniprot id: A0A8D0PY36
uniprot id: I3LVN2
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9823:NAP1L1
gene id: 9823:NAP1L1
uniprot id: A0A287AFP4
uniprot id: A0A8D0IQB7
uniprot id: A0A8D0IUL9
uniprot id: F1SGD7
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9823:RNF135
gene id: 9823:RNF135
uniprot id: A0A481AUQ4
names: Subcellular Location Annotation
messages: Cytoplasm

9823:IL4I1
gene id: 9823:IL4I1
uniprot id: A0A287APE6
uniprot id: A0A287BPT0
uniprot id: A0A4X1VWF2
uniprot id: A0A4X1VYN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

9823:CLDN14
gene id: 9823:CLDN14
uniprot id: A0A4X1TQE4
uniprot id: C3VMK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:SLC6A2
gene id: 9823:SLC6A2
uniprot id: A0A8D1AUF3
uniprot id: F1RF13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9823:ZRANB1
gene id: 9823:ZRANB1
uniprot id: A0A287BI48
uniprot id: A0A4X1VAY5
uniprot id: A0A4X1VBK1
names: Similarity
messages: Belongs to the peptidase C64 family.

9823:GTF2E2
gene id: 9823:GTF2E2
uniprot id: A0A480JVL0
uniprot id: A0A8D1GDX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9823:PAFAH1B1
gene id: 9823:PAFAH1B1
uniprot id: A0A4X1UCH0
uniprot id: A0A8D1Z7V1
uniprot id: Q9GL51
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity. Interacts with the catalytic dimer of PAF-AH (I) heterotetrameric enzyme: interacts with PAFAH1B2 homodimer (alpha2/alpha2 homodimer), PAFAH1B3 homodimer (alpha1/alpha1 homodimer) and PAFAH1B2-PAFAH1B3 heterodimer (alpha2/alpha1 heterodimer) (By similarity). Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Interacts with INTS13. Interacts with DCDC1.
messages: Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity).
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
messages: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).
messages: centrosome
messages: cytoskeleton
messages: spindle

9823:RIBC2
gene id: 9823:RIBC2
uniprot id: A0A480E838
uniprot id: A0A8D1SCA3
names: Similarity
messages: Belongs to the RIB43A family.

9823:AP2B1
gene id: 9823:AP2B1
uniprot id: A0A4X1T854
uniprot id: A0A8D1TQN4
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9823:MMP19
gene id: 9823:MMP19
uniprot id: A0A4X1WB09
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9823:DEGS1
gene id: 9823:DEGS1
uniprot id: A0A8D1JYY1
uniprot id: I3LKA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:BGN
gene id: 9823:BGN
uniprot id: A0A5K1UKC5
uniprot id: A0A8D0ZS93
uniprot id: A0A8D1TM90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: May be involved in collagen fiber assembly.
messages: extracellular matrix

9823:MTX2
gene id: 9823:MTX2
uniprot id: Q2L969
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metaxin family.
messages: Interacts with MTX1/metaxin-1. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex.
messages: Involved in transport of proteins into the mitochondrion.
messages: Mitochondrion
messages: Mitochondrion outer membrane

9823:F11R
gene id: 9823:F11R
uniprot id: A0A8D0IEG6
uniprot id: B2ZI35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9823:PGD
gene id: 9823:PGD
uniprot id: A0A480YSA5
uniprot id: A0A4X1W9L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9823:ARHGEF2
gene id: 9823:ARHGEF2
uniprot id: A0A8D0IE05
uniprot id: A0A8D0ISE8
uniprot id: A0A8D0ISM1
uniprot id: A0A8D0PP82
uniprot id: A0A8D0ZM45
uniprot id: A0A8D0ZRP9
uniprot id: A0A8D1MIA7
uniprot id: A0A8D1MLW2
uniprot id: A0A8D1RDU2
uniprot id: B2DCZ9
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability. Involved in neuronal progenitor cell division and differentiation. Involved in the migration of precerebellar neurons.
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Found in a complex composed at least of ARHGEF2, NOD2 and RIPK2. Interacts with RIPK2; the interaction mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. Interacts with RIPK1 and RIPK3. Interacts with YWHAZ/14-3-3 zeta; when phosphorylated at Ser-860. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts with RHOA and RAC1. Interacts with NOD1 (By similarity). Interacts (via the N- terminal zinc finger) with CAPN6 (via domain II). Interacts with DYNLT1 (By similarity).
messages: Golgi apparatus
messages: Phosphorylation of Ser-860 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4 releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a RIPK2-dependent manner (By similarity).
messages: The DH (DBL-homology) domain promotes tyrosine phosphorylation of RIPK2 (By similarity). The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA.
messages: The PH domain has no affinity for phosphoinositides suggesting that it does not interact directly with membranes.
messages: The phorbol-ester/DAG-type zinc-finger and the C-terminal coiled-coil domains (606-986) are both important for association with microtubules.
messages: Vesicle
messages: cytoskeleton
messages: spindle
messages: tight junction

9823:PSMB8
gene id: 9823:PSMB8
uniprot id: A0A8D0M8J6
uniprot id: A5D9J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9823:LOC100524022
gene id: 9823:LOC100524022
uniprot id: A0A4X1W6A9
names: Similarity
messages: Belongs to the intermediate filament family.

9823:SARM1
gene id: 9823:SARM1
uniprot id: A0A8D1LCA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARM1 family.
messages: axon

9823:VNN1
gene id: 9823:VNN1
uniprot id: Q9BDJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
messages: Cell membrane
messages: Detected in kidney (at protein level).
messages: Monomer.

9823:SLC33A1
gene id: 9823:SLC33A1
uniprot id: A0A4X1SNA5
uniprot id: I3LE25
names: Subcellular Location Annotation
messages: Membrane

9823:LHFPL4
gene id: 9823:LHFPL4
uniprot id: A0A8D0ZDB7
uniprot id: F1SR30
names: Subcellular Location Annotation
messages: Membrane

9823:CCT2
gene id: 9823:CCT2
uniprot id: A0A8D0IU25
uniprot id: D0G0C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9823:KRT36
gene id: 9823:KRT36
uniprot id: A0A287BCS1
uniprot id: A0A8D0ZEJ1
names: Similarity
messages: Belongs to the intermediate filament family.

9823:COG1
gene id: 9823:COG1
uniprot id: A0A286ZIG9
uniprot id: A0A8D0UXS2
uniprot id: A0A8D0X3J6
uniprot id: F1RV32
names: Similarity
messages: Belongs to the COG1 family.

9823:FOXO4
gene id: 9823:FOXO4
uniprot id: A0A8D0YX52
uniprot id: F1RSV5
names: Subcellular Location Annotation
messages: Nucleus

9823:SCFD2
gene id: 9823:SCFD2
uniprot id: A0A4X1U9Q4
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9823:MBTPS1
gene id: 9823:MBTPS1
uniprot id: A0A286ZZH4
uniprot id: A0A8D1MCH9
names: Similarity
messages: Belongs to the peptidase S8 family.

9823:CYB5B
gene id: 9823:CYB5B
uniprot id: A0A480PFJ9
names: Similarity
messages: Belongs to the cytochrome b5 family.

9823:NT5C2
gene id: 9823:NT5C2
uniprot id: A0A4X1TPW3
uniprot id: F1S848
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9823:EMC7
gene id: 9823:EMC7
uniprot id: A0A4X1US46
uniprot id: I3LRK6
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

9823:UBE2C
gene id: 9823:UBE2C
uniprot id: A0A4X1U068
uniprot id: A0A8D0J3L5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:PLET1
gene id: 9823:PLET1
uniprot id: Q7YQE5
names: Caution
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: For human, rat and golden hamster orthologs, a GPI-anchor has been predicted. However, in the case of pig and bovine, no GPI-anchor motifs have been detected, but it does not rule out the possibility of a GPI-anchor instead of a single-pass type I membrane protein.
messages: Highly expressed in placenta.
messages: Membrane
messages: Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).

9823:MZT1
gene id: 9823:MZT1
uniprot id: A0A287AS02
uniprot id: A0A4X1VBW8
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9823:DDR1
gene id: 9823:DDR1
uniprot id: A0A287A959
uniprot id: A0A4X1VE02
uniprot id: A0A4X1VHZ5
uniprot id: A0A4X1VJ08
uniprot id: Q767M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9823:WSCD1
gene id: 9823:WSCD1
uniprot id: A0A8D1RBG9
uniprot id: F1RGL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Golgi apparatus membrane
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

9823:CBFA2T2
gene id: 9823:CBFA2T2
uniprot id: A0A4X1T2W3
uniprot id: A0A8D0W8B8
uniprot id: A0A8D1MV45
names: Similarity
messages: Belongs to the CBFA2T family.

9823:KPNA3
gene id: 9823:KPNA3
uniprot id: A0A4X1SLI0
uniprot id: C6K7I1
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9823:MAP7D1
gene id: 9823:MAP7D1
uniprot id: A0A480VWB2
uniprot id: A0A4X1VX10
uniprot id: A0A4X1VYT8
uniprot id: A0A8D1CM32
names: Similarity
messages: Belongs to the MAP7 family.

9823:RPN1
gene id: 9823:RPN1
uniprot id: Q9GMB0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:7737165). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with TMEM35A/NACHO (By similarity).
messages: Detected in liver (at protein level).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Melanosome
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (Probable). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity).
messages: Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

9823:TLR1
gene id: 9823:TLR1
uniprot id: A0A4X1V574
uniprot id: Q4LDR7
uniprot id: Q59HI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

9823:PDZD11
gene id: 9823:PDZD11
uniprot id: Q6QA76
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with ATP2B1, ATP2B2, ATP2B3, ATP2B4 and ATP7A (By similarity). Interacts with PLEKHA7 (via WW domains) at zonula adherens; this interaction is essential for the interaction between PLEKHA7 and the ADAM10-binding protein TSPAN33 (By similarity). Interacts with SLC5A6 (By similarity).
messages: Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33.
messages: adherens junction

9823:CCNB3
gene id: 9823:CCNB3
uniprot id: A0A4X1SQD0
uniprot id: A0A8D1IQY5
names: Similarity
messages: Belongs to the cyclin family.

9823:SELL
gene id: 9823:SELL
uniprot id: A0A8D0IG50
uniprot id: A8R080
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:CD302
gene id: 9823:CD302
uniprot id: A8WH75
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.
messages: cell cortex
messages: filopodium

9823:HOXC5
gene id: 9823:HOXC5
uniprot id: A0A4X1WAM0
uniprot id: A0A8D0WT82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:APRT
gene id: 9823:APRT
uniprot id: A0A4X1TEA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

9823:AKR1A1
gene id: 9823:AKR1A1
uniprot id: P50578
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Displays no reductase activity towards retinoids (PubMed:12732097).
messages: Monomer.
messages: cytosol

9823:LOC100517145
gene id: 9823:LOC100517145
uniprot id: A0A4X1V0B2
uniprot id: F1S3H9
names: Subcellular Location Annotation
messages: Secreted

9823:GPR55
gene id: 9823:GPR55
uniprot id: A0A287A4Z4
uniprot id: A0A8D0LFR5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:LOC100515394
gene id: 9823:LOC100515394
uniprot id: A0A8D1IIM8
uniprot id: I3LC60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9823:IER5L
gene id: 9823:IER5L
uniprot id: A0A4X1TIH1
names: Similarity
messages: Belongs to the IER family.

9823:PRDX2
gene id: 9823:PRDX2
uniprot id: A0A287BAZ6
uniprot id: A0A8D1XZ09
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9823:EZH2
gene id: 9823:EZH2
uniprot id: A0A4X1USP5
uniprot id: A0A8D0WDY6
uniprot id: A0A8D2BT87
uniprot id: I3L7H6
names: Subcellular Location Annotation
messages: Nucleus

9823:GBA
gene id: 9823:GBA
uniprot id: A0A4X1W0Q8
uniprot id: A0A8D0J2H1
uniprot id: Q70KH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 30 family.
messages: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose. Plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol. GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide. Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers. Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside.
messages: Interacts with saposin-C. Interacts with SCARB2. Interacts with TCP1. Interacts with GRN; this interaction prevents aggregation of GBA1-SCARB2 complex via interaction with HSPA1A upon stress (By similarity).
messages: Lysosome membrane

9823:ACADM
gene id: 9823:ACADM
uniprot id: P41367
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Could occur at proximity of the cofactor-binding sites and reduce the catalytic activity. Could be deacetylated by SIRT3.
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer (PubMed:12966080). Interacts with the heterodimeric electron transfer flavoprotein ETF (By similarity).
messages: Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3233192). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:3233192). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains (By similarity).
messages: Mitochondrion matrix

9823:INO80C
gene id: 9823:INO80C
uniprot id: A0A287B8Q3
uniprot id: A0A4X1V7F8
names: Subcellular Location Annotation
messages: Nucleus

9823:FAM118B
gene id: 9823:FAM118B
uniprot id: A0A480VBD4
uniprot id: A0A8D0RDS4
names: Similarity
messages: Belongs to the FAM118 family.

9823:PGAM2
gene id: 9823:PGAM2
uniprot id: A0A8D0QR32
uniprot id: B5KJG2
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9823:HDAC10
gene id: 9823:HDAC10
uniprot id: A0A4X1UPS6
uniprot id: A0A4X1UQB1
uniprot id: A0A4X1UQB6
uniprot id: I3LDD6
uniprot id: I3LKB5
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.

9823:FOXM1
gene id: 9823:FOXM1
uniprot id: A0A4X1UN77
uniprot id: A0A8D0QLN1
uniprot id: A0A8D0TST7
uniprot id: A0A8D1Y269
uniprot id: I3LTP4
names: Subcellular Location Annotation
messages: Nucleus

9823:CASP2
gene id: 9823:CASP2
uniprot id: A0A480L4F2
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:ARGLU1
gene id: 9823:ARGLU1
uniprot id: A0A4X1U8P3
uniprot id: F2Z517
names: Similarity
messages: Belongs to the UPF0430 family.

9823:CCDC126
gene id: 9823:CCDC126
uniprot id: A0A286ZZT8
uniprot id: A0A8D1AFU6
names: Subcellular Location Annotation
messages: Secreted

9823:NPM3
gene id: 9823:NPM3
uniprot id: A0A8D1HBC5
uniprot id: F1S8T7
names: Similarity
messages: Belongs to the nucleoplasmin family.

9823:SAL1
gene id: 9823:SAL1
uniprot id: P81608
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Binds pheromones, the pheromones are released from the saliva of males and affect the sexual behavior of females.
messages: Homodimer.
messages: In the submaxillary salivary glands of mature male pigs, but absent from that of females. Expression was much lower in submaxillary glands of castrated male pigs than in sexually mature individuals.
messages: Secreted
messages: Two isoforms have been identified which differ by 3 residues.

9823:SLC7A10
gene id: 9823:SLC7A10
uniprot id: A0A4X1TRK2
uniprot id: F1RNW8
names: Subcellular Location Annotation
messages: Membrane

9823:PARP8
gene id: 9823:PARP8
uniprot id: A0A8D1V3L1
uniprot id: F1SMF8
names: Similarity
messages: Belongs to the ARTD/PARP family.

9823:DDX43
gene id: 9823:DDX43
uniprot id: A0A8D1HUW0
uniprot id: A0A8D1MMY8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9823:PPYR1
gene id: 9823:PPYR1
uniprot id: A0A8D1R1X9
uniprot id: O97505
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:LOC106510158
gene id: 9823:LOC106510158
uniprot id: A0A4X1W015
uniprot id: A0A8W4FG29
names: Similarity
messages: Belongs to the LCE family.

9823:KAT2A
gene id: 9823:KAT2A
uniprot id: A0A480V2P3
uniprot id: A0A480VCN1
uniprot id: A0A4X1U6S0
uniprot id: A0A8D1DTJ4
uniprot id: F1S0Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

9823:RIPPLY3
gene id: 9823:RIPPLY3
uniprot id: A0A8D1RU58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9823:BTG3
gene id: 9823:BTG3
uniprot id: A4UTQ2
names: Function
names: Similarity
messages: Belongs to the BTG family.
messages: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.

9823:DKK1
gene id: 9823:DKK1
uniprot id: B8K2M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9823:SLC41A2
gene id: 9823:SLC41A2
uniprot id: A0A4X1TA14
uniprot id: M3VHB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9823:KCNJ11
gene id: 9823:KCNJ11
uniprot id: A0A8D0TWP6
uniprot id: A0A8D1KDB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9823:BOLA1
gene id: 9823:BOLA1
uniprot id: A0A8D1AA70
uniprot id: F1SDF8
names: Similarity
messages: Belongs to the BolA/IbaG family.

9823:GLOD4
gene id: 9823:GLOD4
uniprot id: A0A480U068
uniprot id: A0A8D2A5Z8
names: Similarity
messages: Belongs to the glyoxalase I family.

9823:CA5B
gene id: 9823:CA5B
uniprot id: A0A8D0JCV2
uniprot id: A0A8D1CH84
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9823:LOC100155752
gene id: 9823:LOC100155752
uniprot id: A0A287A242
uniprot id: A0A8D1XB16
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:IMP3
gene id: 9823:IMP3
uniprot id: A0A8D0X6D5
uniprot id: F1SJ73
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9823:AGPAT3
gene id: 9823:AGPAT3
uniprot id: A0A4X1TE98
uniprot id: B8XTR1
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9823:NUP85
gene id: 9823:NUP85
uniprot id: A0A4X1V047
uniprot id: F1RVX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9823:TPI1
gene id: 9823:TPI1
uniprot id: Q29371
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

9823:SLC26A3
gene id: 9823:SLC26A3
uniprot id: A0A4X1V0S9
uniprot id: B5A4B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane

9823:HTRA1
gene id: 9823:HTRA1
uniprot id: A0A480RHM1
uniprot id: A0A8D0WWI6
names: Similarity
messages: Belongs to the peptidase S1C family.

9823:IRF6
gene id: 9823:IRF6
uniprot id: A0A8D2BU03
uniprot id: E9LK28
uniprot id: Q8WNQ4
names: Subcellular Location Annotation
messages: Nucleus

9823:CDH24
gene id: 9823:CDH24
uniprot id: A0A4X1V5K2
uniprot id: F1S9C8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9823:MTM1
gene id: 9823:MTM1
uniprot id: A0A4X1SXZ1
uniprot id: A0A4X1SY68
uniprot id: A0A8D0TB12
uniprot id: A0A8D0TC74
uniprot id: A0A8D1CI27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9823:FAM221B
gene id: 9823:FAM221B
uniprot id: A0A4X1VT10
uniprot id: A0A8D1AUQ0
names: Similarity
messages: Belongs to the FAM221 family.

9823:PTPA
gene id: 9823:PTPA
uniprot id: A0A4X1TIP6
uniprot id: A0A4X1TLC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9823:ADGRE5
gene id: 9823:ADGRE5
uniprot id: Q95L62
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:SDHB
gene id: 9823:SDHB
uniprot id: Q007T0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (PubMed:15989954). Interacts with SDHAF1; the interaction is required for iron-sulfur cluster incorporation into SDHB (By similarity).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9823:ZDHHC8
gene id: 9823:ZDHHC8
uniprot id: A0A480WNM2
uniprot id: A0A4X1UQJ5
uniprot id: A0A8D1CFG5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:IGFBP2
gene id: 9823:IGFBP2
uniprot id: E3W6T5
uniprot id: P24853
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May have both growth-inhibiting and growth-promoting effects, depending on tissue type; increases IGF-induced DNA synthesis in the uterine epithelium. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: O-glycosylated.
messages: Secreted
messages: The C-terminus is required for IGF-binding and growth inhibition.

9823:RABGGTB
gene id: 9823:RABGGTB
uniprot id: A0A4X1ULX5
uniprot id: F1S9R0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9823:SLC16A4
gene id: 9823:SLC16A4
uniprot id: A0A287AYI2
uniprot id: A0A8D0T2U1
uniprot id: A0A8D0ZSA9
uniprot id: F1S621
names: Subcellular Location Annotation
messages: Membrane

9823:TRPC3
gene id: 9823:TRPC3
uniprot id: A0A480ZVG7
uniprot id: A0A4X1V9R6
uniprot id: C0JJ15
uniprot id: F1S1U0
names: Subcellular Location Annotation
messages: Membrane

9823:RARRES1
gene id: 9823:RARRES1
uniprot id: A0A5G2QJW9
uniprot id: A0A8D0PWW4
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9823:S1PR2
gene id: 9823:S1PR2
uniprot id: A0A8D1SE16
uniprot id: F1S3I6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:LOC100525684
gene id: 9823:LOC100525684
uniprot id: A0A4X1UZD7
uniprot id: A0A5G2RBM4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SIX6
gene id: 9823:SIX6
uniprot id: A0A8D1IVG3
uniprot id: F1SSH9
names: Subcellular Location Annotation
messages: Nucleus

9823:ZSCAN23
gene id: 9823:ZSCAN23
uniprot id: A0A4X1VKI8
uniprot id: A0A8D0HQL1
uniprot id: A0A8D0W5G6
names: Subcellular Location Annotation
messages: Nucleus

9823:C15H2orf88
gene id: 9823:C15H2orf88
uniprot id: A0A287ABE0
uniprot id: A0A8D0SAJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9823:WDFY1
gene id: 9823:WDFY1
uniprot id: A0A287AXD6
uniprot id: A0A4X1UAW7
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9823:ORC4
gene id: 9823:ORC4
uniprot id: A0A4X1THM5
uniprot id: A0A8D1WJX0
uniprot id: F1S0H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9823:SKIV2L
gene id: 9823:SKIV2L
uniprot id: A0A4X1VBX9
uniprot id: A5PEZ4
names: Subcellular Location Annotation
messages: Cytoplasm

9823:LOC100521773
gene id: 9823:LOC100521773
uniprot id: A0A4X1SXZ4
uniprot id: A0A5G2QU99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:F10
gene id: 9823:F10
uniprot id: Q19AZ6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:CDC37
gene id: 9823:CDC37
uniprot id: A0A8D0TK45
uniprot id: Q684M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9823:CBR3
gene id: 9823:CBR3
uniprot id: A0A8D0I029
uniprot id: F1SGX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9823:IFN-ALPHA-16
gene id: 9823:IFN-ALPHA-16
uniprot id: C8CKA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:RPS6
gene id: 9823:RPS6
uniprot id: A0A4X1WBG6
uniprot id: A0A8D1U697
uniprot id: F2Z5Q6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

9823:LOC100625464
gene id: 9823:LOC100625464
uniprot id: A0A4X1U492
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9823:LOC106504185
gene id: 9823:LOC106504185
uniprot id: A0A4X1SV90
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:KCNAB1
gene id: 9823:KCNAB1
uniprot id: A0A4X1SL46
uniprot id: Q1EFM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9823:TBC1D7
gene id: 9823:TBC1D7
uniprot id: A0A287A809
uniprot id: A0A4X1VJN5
uniprot id: A0A4X1VQ82
uniprot id: F1RV80
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9823:WISP2
gene id: 9823:WISP2
uniprot id: A0A287BT12
uniprot id: A0A8D0KG38
names: Similarity
messages: Belongs to the CCN family.

9823:MYCBP
gene id: 9823:MYCBP
uniprot id: A0A8D1GIK9
uniprot id: A0A8D1WCH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

9823:TLR6
gene id: 9823:TLR6
uniprot id: Q59HI6
uniprot id: Q76L23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9823:PEPD
gene id: 9823:PEPD
uniprot id: A0A8D1LAP7
names: Similarity
messages: Belongs to the peptidase M24B family.

9823:RAB11A
gene id: 9823:RAB11A
uniprot id: Q52NJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Endosome membrane
messages: Golgi apparatus
messages: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4 (By similarity). Forms a complex with RAB11FIP3 and dynein intermediate chain DYNC1LI1; the interaction between RAB11A1 and RAB11FIP3 is direct; the complex regulates endocytic trafficking (By similarity). Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A (By similarity). Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39 (By similarity). Interacts with EXOC6 in a GTP-dependent manner. Interacts with RAB11FIP5. Interacts with STXBP6. Interacts (GDP-bound form) with ZFYVE27 (By similarity). Interacts with BIRC6/bruce (By similarity). May interact with TBC1D14 (By similarity). Interacts with UNC119; in a cell cycle-dependent manner (By similarity). GDP-bound and nucleotide-free forms interact with SH3BP5 (By similarity). Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts (GDP-bound form) with RELCH (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity). Interacts with TBC1D12 (By similarity). Interacts with DEF6 (By similarity). Interacts with ATP9A (By similarity). Forms a heterotetramer with RAB11FIP3; the GTP-bound form is preferred for binding. Forms a complex with Rabin8/RAB3IP and RAB11FIP3, probably a heterohexamer with two of each protein subunit, where Rabin8/RAB3IP and RAB11FIP3 simultaneously bind to RAB11A; the complex promotes preciliary trafficking and cilia growth. Forms a complex containing RAB11A, ASAP1, Rabin8/RAB3IP, RAP11FIP3 and ARF4; the complex promotes preciliary trafficking; the complex binds to RHO in photoreceptor cells and promotes RHO ciliary transport. Interacts (GTP-bound form) with WDR44; the interaction prevents RAB11A-RAB3IP-RAB11FIP3 complex formation (By similarity).
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). The small Rab GTPase RAB11A regulates endocytic recycling (By similarity). Forms a functional Rab11/FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (By similarity). Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation. On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3…
messages: phagosome
messages: trans-Golgi network

9823:EML4
gene id: 9823:EML4
uniprot id: A0A287AHD3
uniprot id: A0A8D0WAP0
uniprot id: A0A8D1LSN3
names: Similarity
messages: Belongs to the WD repeat EMAP family.

9823:ALG11
gene id: 9823:ALG11
uniprot id: A0A8D0WRK8
uniprot id: A0A8W4FJK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

9823:PPARD
gene id: 9823:PPARD
uniprot id: A0A4X1T1Q5
uniprot id: A9XAM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:FRRS1
gene id: 9823:FRRS1
uniprot id: A0A4X1TVL3
uniprot id: B2ZDZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

9823:PPAN
gene id: 9823:PPAN
uniprot id: A0A4X1UXW0
uniprot id: F1S3I2
names: Subcellular Location Annotation
messages: nucleolus

9823:PIGK
gene id: 9823:PIGK
uniprot id: Q4KRV1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Component of the GPI transamidase complex, necessary for transfer of GPI to proteins (By similarity). Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity).
messages: Endoplasmic reticulum membrane
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.
messages: The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity.

9823:ABCF1
gene id: 9823:ABCF1
uniprot id: Q767L0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm
messages: Interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated status. Associates (via both ABC transporter domains) with the ribosomes (By similarity).
messages: Nucleus envelope
messages: Phosphorylated at phosphoserine and phosphothreonine. Phosphorylation on Ser-110 and Ser-141 by CK2; inhibits association of EIF2 with ribosomes (By similarity).
messages: Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity).
messages: nucleoplasm

9823:TM4SF20
gene id: 9823:TM4SF20
uniprot id: A0A8D0Z7Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9823:DNASE2
gene id: 9823:DNASE2
uniprot id: O62855
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase II family.
messages: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells.
messages: Lysosome

9823:RAB32
gene id: 9823:RAB32
uniprot id: Q06AU5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Interacts with ANKRD27. A decreased interaction with ANKRD27 seen in the presence of SGSM2 (By similarity).
messages: Melanosome
messages: Melanosome membrane
messages: Mitochondrion
messages: Mitochondrion outer membrane
messages: Regulated by a guanine nucleotide-exchange factor (GEF) and a GTPase-activating protein (GAP) and alternates between an inactive GDP-bound and an active GTP-bound form. The BLOC-3 complex composed of HPS1 and HPS4 acts as its GEF, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. SGSM2 acts as its GAP and inactivates it by stimulating its GTPase activity.
messages: phagosome
messages: phagosome membrane

9823:IHH
gene id: 9823:IHH
uniprot id: A0A4X1UI09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9823:PLPP1
gene id: 9823:PLPP1
uniprot id: A0A286ZXH9
uniprot id: A0A4X1SL15
uniprot id: A0A4X1SM48
uniprot id: A0A4X1SM51
uniprot id: A0A8D0ILX9
uniprot id: P60588
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Forms functional homodimers and homooligomers that are not required for substrate recognition and catalytic activity (By similarity). Can also form heterooligomers with PLPP2 and PLPP3 (By similarity).
messages: Magnesium-independent phospholipid phosphatase (PubMed:1334090). Insensitive to N-ethylmaleimide (PubMed:1334090).
messages: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (Ref.1, PubMed:8702556, PubMed:1334090). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (By similarity). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (By similarity). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (By similarity). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity).
messages: Membrane
messages: Membrane raft
messages: N-glycosylated. N-linked sugars are of the complex type (PubMed:8702556). N-glycosylation is not required for the phosphatase activity (By similarity).
messages: caveola

9823:ACSM4
gene id: 9823:ACSM4
uniprot id: A0A8D1CNJ0
uniprot id: I3LSY0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:PSMB5
gene id: 9823:PSMB5
uniprot id: A0A480WQB6
uniprot id: A0A4X1V3T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9823:GNRHR
gene id: 9823:GNRHR
uniprot id: P49922
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Pituitary gland.
messages: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

9823:TYK2
gene id: 9823:TYK2
uniprot id: A0A8D1VBB5
uniprot id: Q684M7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9823:LOC100525099
gene id: 9823:LOC100525099
uniprot id: A0A480EIC9
uniprot id: A0A4X1TZY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

9823:ATP5G1
gene id: 9823:ATP5G1
uniprot id: A0A4X1URD9
uniprot id: A0A8D1MZ36
uniprot id: Q4VT52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9823:ART3
gene id: 9823:ART3
uniprot id: A0A5K1UHA8
uniprot id: A0A8D1KVI6
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9823:CTNNB1
gene id: 9823:CTNNB1
uniprot id: A0A4X1TKY9
uniprot id: Q8WNW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9823:TSNAX
gene id: 9823:TSNAX
uniprot id: A0A287B8Q8
uniprot id: A0A4X1U8N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9823:MCHR1
gene id: 9823:MCHR1
uniprot id: Q5QPY1
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

9823:DKK3
gene id: 9823:DKK3
uniprot id: A0A4X1TS89
uniprot id: Q2HWR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9823:RPS12
gene id: 9823:RPS12
uniprot id: A0A480QPE7
uniprot id: P46405
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS12 family.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Subunit of the 40S ribosomal complex (By similarity).
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Subunit of the 40S ribosomal complex (By similarity).
messages: nucleolus

9823:TLR7
gene id: 9823:TLR7
uniprot id: A4LAL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
messages: Lysosome
messages: Membrane
messages: phagosome

9823:MSH5
gene id: 9823:MSH5
uniprot id: B9TSR3
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9823:MRPS24
gene id: 9823:MRPS24
uniprot id: A0A4X1U9V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

9823:ATP5G3
gene id: 9823:ATP5G3
uniprot id: A0A286ZIA7
uniprot id: A0A8D1CDT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9823:ITGB1BP2
gene id: 9823:ITGB1BP2
uniprot id: Q462R2
names: Domain
names: Function
names: Subunit
messages: Interacts with beta-1 integrin subunit. This interaction is regulated by divalent cations, and it occurs only in absence of calcium (By similarity).
messages: May play a role during maturation and/or organization of muscles cells.
messages: The tail domain binds to the cytoplasmic domain of both integrin beta-1a and beta-1d isoforms. The presence of Ca(2+) ions does not prevent binding of a fragment consisting of the second cysteine rich repeat and the tail domain but prevents the binding of the full-length protein (By similarity).

9823:POU1F1
gene id: 9823:POU1F1
uniprot id: A0A4X1UP07
uniprot id: A0A8D0Q633
uniprot id: A0A8D1CKF7
uniprot id: D9ZNP5
uniprot id: Q04788
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family.
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Interacts with PITX1. Interacts with LHX3. Interacts with ELK1.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

9823:GLO1
gene id: 9823:GLO1
uniprot id: A0A8D0M1K9
uniprot id: A0A8D0PDF1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9823:RPS6KA3
gene id: 9823:RPS6KA3
uniprot id: A0A4X1VBK6
uniprot id: A0A8D0KCF4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9823:CDIP1
gene id: 9823:CDIP1
uniprot id: A0A4X1VRS3
uniprot id: A0A8D1X711
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9823:IL29
gene id: 9823:IL29
uniprot id: B8XX89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9823:EIF4EBP2
gene id: 9823:EIF4EBP2
uniprot id: A0A286ZLA1
uniprot id: A0A4X1TF49
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9823:CPN1
gene id: 9823:CPN1
uniprot id: A0A4X1U4Z6
uniprot id: F1S8V7
names: Similarity
messages: Belongs to the peptidase M14 family.

9823:SLC35C2
gene id: 9823:SLC35C2
uniprot id: A0A287BSR3
uniprot id: A0A4X1U4I4
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100154852
gene id: 9823:LOC100154852
uniprot id: A0A8W4FID5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RPL36
gene id: 9823:RPL36
uniprot id: A0A4X1VRZ2
uniprot id: A0A8W4FBD1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

9823:RUNDC3A
gene id: 9823:RUNDC3A
uniprot id: A0A480R322
uniprot id: A0A480WGU6
uniprot id: A0A480X0B9
uniprot id: A0A481C7D5
uniprot id: A0A4X1TM13
uniprot id: F1RQY5
names: Similarity
messages: Belongs to the RUNDC3 family.

9823:UGCG
gene id: 9823:UGCG
uniprot id: A0A4X1V638
uniprot id: I3LPG3
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9823:AOC1
gene id: 9823:AOC1
uniprot id: Q9TRC7
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copper/topaquinone oxidase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 2 calcium ions per subunit.
messages: Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis.
messages: Contains 1 topaquinone per subunit.
messages: Homodimer; disulfide-linked.
messages: Inhibited by amiloride in a competitive manner.
messages: N-glycosylated; the glycans are primarily linear, di-, or tribranched fucosylated complex type.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
messages: extracellular space

9823:TMEM265
gene id: 9823:TMEM265
uniprot id: A0A4X1TQ89
uniprot id: A0A8D1T421
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:CENPH
gene id: 9823:CENPH
uniprot id: A0A4X1UK66
uniprot id: I3LPJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

9823:GUCA2B
gene id: 9823:GUCA2B
uniprot id: O13009
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity).
messages: Secreted

9823:LOC100523244
gene id: 9823:LOC100523244
uniprot id: A0A287A0K4
uniprot id: A0A287ATT3
uniprot id: A0A4X1VIX7
uniprot id: A0A4X1VP91
uniprot id: A0A4X1VQD2
uniprot id: F1SKP7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:EBNA1BP2
gene id: 9823:EBNA1BP2
uniprot id: A0A480XE79
uniprot id: A0A8D1YDW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

9823:NXT2
gene id: 9823:NXT2
uniprot id: A0A4X1W4F7
uniprot id: K7GNP4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9823:TGM5
gene id: 9823:TGM5
uniprot id: A0A4X1V5M8
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9823:HSPB7
gene id: 9823:HSPB7
uniprot id: A0A287A0M1
uniprot id: A0A4X1W7Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Nucleus

9823:PDE2A
gene id: 9823:PDE2A
uniprot id: A0A287B1D3
uniprot id: F1SUV3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9823:UCP2
gene id: 9823:UCP2
uniprot id: A0A480XUE6
uniprot id: O97562
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle lowering the ATP/ADP ratio and reactive oxygen species (ROS) production (By similarity). Proton transporter activity is debated, but if it occurs it may mediate inducible proton re-entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. Proton re-entry may be coupled to metabolite transport to allow for proton flux switching and optimal ATP turnover (By similarity). Regulates the use of glucose as a source of energy. Required for glucose-induced DRP1-dependent mitochondrial fission and neuron activation in the ventromedial nucleus of the hypothalamus (VMH). This mitochondrial adaptation mechanism modulates the VMH pool of glucose-excited neurons with an impact on systemic glucose homeostasis. Regulates ROS levels and metabolic reprogramming of macrophages during the resolution phase of inflammation. Attenuates ROS production in response to IL33 to preserve the integrity of the Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). Can unidirectionally transport anions including L-malate, L-aspartate, phosphate and chloride ions (By similarity). Does not mediate adaptive thermogenesis (By similarity).
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Homotetramer. Adopts an asymmetrical dimer of dimers functional form.
messages: Membrane
messages: Mitochondrion inner membrane

9823:SEC61A2
gene id: 9823:SEC61A2
uniprot id: A0A4X1TFK8
uniprot id: F2Z5D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:CHRDL1
gene id: 9823:CHRDL1
uniprot id: A0A8D1SZR5
uniprot id: A0A8D1Z9I8
uniprot id: K7GRE3
names: Subcellular Location Annotation
messages: Secreted

9823:METTL14
gene id: 9823:METTL14
uniprot id: A0A287ARJ1
uniprot id: A0A8D0T630
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MT-A70-like family.
messages: Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.
messages: Nucleus
messages: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells.

9823:ENPEP
gene id: 9823:ENPEP
uniprot id: Q95334
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.
messages: Substrate specificity is modulated by calcium which enhances the enzymatic activity for cleavage of acidic residues while reducing its activity with basic residues. Inhibited by aminopeptidase inhibitors amastatin and bestatin.

9823:LOC100622582
gene id: 9823:LOC100622582
uniprot id: A0A4X1TB90
uniprot id: A0A5G2R2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC110255227
gene id: 9823:LOC110255227
uniprot id: A0A286ZR33
uniprot id: A0A8D1APW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MMP11
gene id: 9823:MMP11
uniprot id: A0A4X1V105
uniprot id: A0A8D0MUM1
uniprot id: A0A8D1B7F9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9823:DDRGK1
gene id: 9823:DDRGK1
uniprot id: A0A287BPF3
uniprot id: A0A8D1ZLK5
names: Similarity
messages: Belongs to the DDRGK1 family.

9823:LOC100522475
gene id: 9823:LOC100522475
uniprot id: A0A8D1XR14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RPS3A
gene id: 9823:RPS3A
uniprot id: B6V8C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

9823:NR0B2
gene id: 9823:NR0B2
uniprot id: A0A8D1XQX8
uniprot id: F1STR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9823:NTN1
gene id: 9823:NTN1
uniprot id: Q2HXW4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and probably UNC5D. Binds to its receptor; DSCAM (By similarity). Interacts with APP (By similarity).
messages: Cytoplasm
messages: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity).
messages: Secreted

9823:SLC29A3
gene id: 9823:SLC29A3
uniprot id: A0A480J615
uniprot id: A0A8D1U9J0
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9823:DDX49
gene id: 9823:DDX49
uniprot id: A0A4X1U6Y4
uniprot id: F1S7D9
names: Similarity
messages: Belongs to the DEAD box helicase family.

9823:TSSK6
gene id: 9823:TSSK6
uniprot id: A0A4X1TZ99
uniprot id: F1S6Q0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:TXNL4A
gene id: 9823:TXNL4A
uniprot id: A0A287A0V4
uniprot id: A0A4X1SCZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9823:LOC100621347
gene id: 9823:LOC100621347
uniprot id: A0A4X1TFW9
uniprot id: A0A8W4FGU7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9823:DNAJC22
gene id: 9823:DNAJC22
uniprot id: F1SHB7
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

9823:KLF9
gene id: 9823:KLF9
uniprot id: P79288
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Interacts with ZZEF1.
messages: Nucleus
messages: Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation.

9823:IFNK
gene id: 9823:IFNK
uniprot id: A0A8D0VVG3
uniprot id: C8CKC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:LOC100519554
gene id: 9823:LOC100519554
uniprot id: A0A8W4F908
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TRMT2A
gene id: 9823:TRMT2A
uniprot id: A0A8D2A912
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:TDRD3
gene id: 9823:TDRD3
uniprot id: A0A480PRD9
uniprot id: A0A4X1VEY8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1.

9823:NMI
gene id: 9823:NMI
uniprot id: A0A8D1G870
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9823:DEFB1
gene id: 9823:DEFB1
uniprot id: H9ZGM8
uniprot id: O62697
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-defensin family.
messages: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
messages: Membrane
messages: Monomer. Homodimer.
messages: Secreted

9823:FAM83A
gene id: 9823:FAM83A
uniprot id: A0A8D1NE53
uniprot id: F1RR13
names: Similarity
messages: Belongs to the FAM83 family.

9823:POFUT1
gene id: 9823:POFUT1
uniprot id: A0A8D1D1Y7
uniprot id: Q00P49
names: Similarity
messages: Belongs to the glycosyltransferase 65 family.

9823:LOC100156225
gene id: 9823:LOC100156225
uniprot id: A0A8D0ZIZ2
uniprot id: A0A8D1K560
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PIWIL4
gene id: 9823:PIWIL4
uniprot id: A0A8D0ZPK5
uniprot id: F1STJ5
names: Similarity
messages: Belongs to the argonaute family.

9823:GIMAP8
gene id: 9823:GIMAP8
uniprot id: A0A4X1UZB7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9823:PPP2R5A
gene id: 9823:PPP2R5A
uniprot id: A6XAC5
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9823:LOC100621421
gene id: 9823:LOC100621421
uniprot id: A0A8D0SGP5
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9823:TACSTD2
gene id: 9823:TACSTD2
uniprot id: A0A8D1BAJ3
uniprot id: F1S7A4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:PELI3
gene id: 9823:PELI3
uniprot id: A0A480L492
uniprot id: A0A4X1TL40
uniprot id: A0A4X1TNC3
uniprot id: K7GS70
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9823:B3GNT3
gene id: 9823:B3GNT3
uniprot id: A0A8D0USZ1
uniprot id: A0A8D1NRV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:MTERF1
gene id: 9823:MTERF1
uniprot id: A0A286ZTW7
uniprot id: A0A287A9T5
uniprot id: A0A287AN15
uniprot id: A0A4X1U992
uniprot id: A0A8D1FTE7
names: Similarity
messages: Belongs to the mTERF family.

9823:TEAD3
gene id: 9823:TEAD3
uniprot id: Q2VI02
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

9823:UTP6
gene id: 9823:UTP6
uniprot id: A0A4X1TGP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

9823:ZDHHC16
gene id: 9823:ZDHHC16
uniprot id: A0A287B8T5
uniprot id: A0A480VAV8
uniprot id: A0A4X1U9U9
uniprot id: A0A8D0N3C0
uniprot id: A0A8D1EJ15
uniprot id: A0A8D1GMI2
uniprot id: A0A8D1XS58
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:PLA2G4B
gene id: 9823:PLA2G4B
uniprot id: A0A4X1V0R9
uniprot id: A0A8D0SD76
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9823:RAB27A
gene id: 9823:RAB27A
uniprot id: A0A480LWT0
uniprot id: Q4LE85
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Binds SYTL1, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5. Interacts with RPH3A and RPH3A (By similarity). Binds MLPH and SYTL2. Interacts with UNC13D. Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4) (By similarity). Interacts (GDP-bound form preferentially) with DENND10 (By similarity).
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Melanosome
messages: Membrane
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as DENND10.
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.

9823:STX1A
gene id: 9823:STX1A
uniprot id: A0A8D1ELH2
names: Similarity
messages: Belongs to the syntaxin family.

9823:URM1
gene id: 9823:URM1
uniprot id: A0A4X1TT68
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

9823:RABGGTA
gene id: 9823:RABGGTA
uniprot id: A5A779
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
messages: Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp (By similarity). Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A disrupts this interaction (By similarity).
messages: The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.

9823:CEBPG
gene id: 9823:CEBPG
uniprot id: A0A8D0UQU5
uniprot id: F1RNW5
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

9823:TRMT5
gene id: 9823:TRMT5
uniprot id: A0A4X1W7D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

9823:CTPS2
gene id: 9823:CTPS2
uniprot id: A0A4X1UU82
uniprot id: A0A4X1UZ55
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9823:FUZ
gene id: 9823:FUZ
uniprot id: A0A4X1VWL1
uniprot id: F1RH61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fuzzy family.
messages: cytoskeleton

9823:EXOC2
gene id: 9823:EXOC2
uniprot id: A0A4X1SYB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9823:PKIB
gene id: 9823:PKIB
uniprot id: A0A8D0ZH79
uniprot id: F1SF58
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9823:FXYD5
gene id: 9823:FXYD5
uniprot id: A0A480K3L9
names: Similarity
messages: Belongs to the FXYD family.

9823:EDC3
gene id: 9823:EDC3
uniprot id: A0A4X1TMS6
uniprot id: A0A8D0SQY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9823:C4BPA
gene id: 9823:C4BPA
uniprot id: A0A480QKV0
uniprot id: Q03472
names: Caution
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Forms high molecular weight disulfide-linked complexes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be a lipoprotein-borne regulator of either the coagulation or the complement cascades.
messages: Plasma. Found on very low-density lipoprotein (VLDL), on chylomicrons, and in the D > 1.21 g/ml fraction of pig plasma. Found in liver, spleen, lung, bone marrow and lymph node.
messages: Secreted
messages: Terminally differentiated macrophages.

9823:CALCR
gene id: 9823:CALCR
uniprot id: A0A480PVE3
uniprot id: P25117
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane
messages: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells.

9823:CLIC2
gene id: 9823:CLIC2
uniprot id: A0A4X1T8K6
uniprot id: A0A8D1KQW9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9823:ABRAXAS1
gene id: 9823:ABRAXAS1
uniprot id: A0A8D0MVG9
uniprot id: F1RW10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Nucleus

9823:MCM2
gene id: 9823:MCM2
uniprot id: A0A4X1TY86
uniprot id: F1SPF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9823:TMED5
gene id: 9823:TMED5
uniprot id: A0A4X1U2C1
uniprot id: A0A8D1NRM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9823:POR
gene id: 9823:POR
uniprot id: P04175
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

9823:IL25
gene id: 9823:IL25
uniprot id: A0A345AI55
uniprot id: A0A8D0MW70
names: Similarity
messages: Belongs to the IL-17 family.

9823:SCAMP1
gene id: 9823:SCAMP1
uniprot id: O77735
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAMP family.
messages: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
messages: Interacts with SYNRG, ITSN1 and SLC9A7.
messages: Recycling endosome membrane
messages: trans-Golgi network membrane

9823:EIF2AK3
gene id: 9823:EIF2AK3
uniprot id: A0A480XY09
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9823:C2H19orf66
gene id: 9823:C2H19orf66
uniprot id: A0A8D1JJ11
uniprot id: F1S3I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Cytoplasm
messages: Nucleus

9823:CD40
gene id: 9823:CD40
uniprot id: Q8SQ34
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).
messages: Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).

9823:YIPF5
gene id: 9823:YIPF5
uniprot id: A0A8D1TWJ5
uniprot id: Q06AA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9823:MTHFD1
gene id: 9823:MTHFD1
uniprot id: A0A4X1UGR4
uniprot id: F1SA74
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9823:ACY1
gene id: 9823:ACY1
uniprot id: A0A480XYA6
uniprot id: P37111
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-acetylated amino acids to acetate and free amino acids.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with SPHK1 (By similarity).

9823:S1PR5
gene id: 9823:S1PR5
uniprot id: Q684M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins (By similarity).

9823:CLRN1
gene id: 9823:CLRN1
uniprot id: A0A287B3L8
uniprot id: A0A8D1ZWP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9823:HOXA6
gene id: 9823:HOXA6
uniprot id: A0A4X1TPF8
uniprot id: A0A8D0KBA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:FAM212B
gene id: 9823:FAM212B
uniprot id: A0A8D0ZQB2
uniprot id: A0A8D1YTE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9823:PMPCB
gene id: 9823:PMPCB
uniprot id: A0A480T8S4
uniprot id: A0A8D2A151
names: Similarity
messages: Belongs to the peptidase M16 family.

9823:PRPSAP1
gene id: 9823:PRPSAP1
uniprot id: A0A4X1UUX0
uniprot id: A0A8D0I851
uniprot id: F1RWP0
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9823:MSTN
gene id: 9823:MSTN
uniprot id: Q6SVB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted

9823:CEBPD
gene id: 9823:CEBPD
uniprot id: A0A287B3B3
uniprot id: A0A8D1IY46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9823:PMM1
gene id: 9823:PMM1
uniprot id: A0A4X1VXB7
uniprot id: F1SRD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9823:ENPP2
gene id: 9823:ENPP2
uniprot id: A0A286ZKF8
uniprot id: A0A287B762
uniprot id: A0A480K6K5
uniprot id: A0A480PNW7
uniprot id: A0A480R8I2
uniprot id: A0A8D0KAI0
uniprot id: A0A8D0QTZ7
uniprot id: A0A8D1GXZ9
uniprot id: A0A8D1H3Q0
uniprot id: A0A8D1K9V8
uniprot id: A0A8D1YJN9
uniprot id: A0A8D1YLB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9823:LOC574051
gene id: 9823:LOC574051
uniprot id: Q4TTS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9823:MTMR2
gene id: 9823:MTMR2
uniprot id: A0A287AUM4
uniprot id: A0A4X1TQU0
uniprot id: A0A4X1TVN4
uniprot id: A0A4X1TW24
uniprot id: F1STI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9823:TMOD1
gene id: 9823:TMOD1
uniprot id: A0A4X1UDZ5
uniprot id: A0A8D1MAI6
names: Subcellular Location Annotation
messages: cytoskeleton

9823:CDH5
gene id: 9823:CDH5
uniprot id: B4YYE0
uniprot id: O02840
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (By similarity). Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity).
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell junction
messages: Cell membrane
messages: Interacts (via cadherin 5 domain) with PTPRB (By similarity). Interacts with TRPC4 (By similarity). Interacts with KRIT1 (By similarity). Interacts with PARD3 (By similarity). Interacts with RTN4 (isoform B) (By similarity). Interacts with PALS1; the interaction promotes PALS1 localization to cell junctions and is required for CDH5-mediated vascular lumen formation and endothelial cell (By similarity).
messages: Membrane
messages: O-glycosylated.
messages: Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity).
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9823:WDR12
gene id: 9823:WDR12
uniprot id: A0A4X1V7X7
uniprot id: F1SHE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9823:HDHD2
gene id: 9823:HDHD2
uniprot id: A0A8D1M2Q5
uniprot id: F1RZX9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9823:BAG6
gene id: 9823:BAG6
uniprot id: A5D9M6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides an…
messages: Component of the BAG6/BAT3 complex, also named BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with GET4; the interaction is direct and localizes BAG6 in the cytosol. Interacts with UBL4A; the interaction is direct and required for UBL4A protein stability. Interacts with AIFM1. Interacts with HSPA2. Interacts with CTCFL. Interacts with p300/EP300. Interacts (via ubiquitin-like domain) with RNF126; required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts (via ubiquitin-like domain) with SGTA; SGTA competes with RNF126 by binding the same region of BAG6, thereby promoting deubiquitination of BAG6-target proteins and rescuing them from degradation. Interacts with ricin A chain. Interacts with VCP and AMFR; both form the VCP/p97-AMFR/gp78 complex. Interacts with SYVN1. Interacts with USP13; the interaction is direct and may mediate UBL4A deubiquitination. Interacts with ZFAND2B. Interacts with KPNA2. Interacts with UBQLN4 (By similarity).
messages: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2).
messages: May mediate ricin-induced apoptosis.
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: Ricin can induce a cleavage by the caspase CASP3. The released C-terminal peptide induces apoptosis.
messages: The ubiquitin-like domain mediates interaction with the E3 ubiquitin-protein ligase RNF126 which is responsible for the BAG6-dependent ubiquitination of client proteins. SGTA also binds this domain and competes with RNF126 to antagonize client protein ubiquitination and degradation. The ubiquitin-like domain also mediates the interaction with USP13.
messages: cytosol
messages: extracellular exosome

9823:HMGB3
gene id: 9823:HMGB3
uniprot id: A0A287BHQ2
uniprot id: A0A8D0JTT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9823:DNPEP
gene id: 9823:DNPEP
uniprot id: A0A480KKD6
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9823:ARSG
gene id: 9823:ARSG
uniprot id: A0A287A0M2
uniprot id: A0A8D1SKF2
names: Similarity
messages: Belongs to the sulfatase family.

9823:LDLR
gene id: 9823:LDLR
uniprot id: Q28832
uniprot id: W0G5E7
names: Caution
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
messages: Cell membrane
messages: Defects in LDLR are the cause of familial hypercholesterolemia (FH).
messages: Early endosome
messages: Golgi apparatus
messages: Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts (via NPXY motif) with LDLRAP1 (via PID domain). Interacts with ARRB1. Interacts with SNX17. Interacts with the full-length immature form of PCSK9 (via C-terminus).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Late endosome
messages: Lysosome
messages: N- and O-glycosylated.
messages: The NPXY motif mediates the interaction with the clathrin adapter DAB2 and with LDLRAP1 which are involved in receptor internalization. A few residues outside the motif also play a role in the interaction.
messages: Ubiquitinated by MYLIP leading to degradation.
messages: clathrin-coated pit

9823:GRK7
gene id: 9823:GRK7
uniprot id: Q8WP15
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.
messages: Autophosphorylated in vitro at Ser-490 (By similarity). Phosphorylation at Ser-36 is regulated by light and activated by cAMP.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
messages: Inhibited by phosphorylation of Ser-36.
messages: Interacts (when prenylated) with PDE6D; this promotes release from membranes.
messages: Membrane
messages: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).

9823:PI4KA
gene id: 9823:PI4KA
uniprot id: A0A480IQK1
uniprot id: A0A8D1S7Q5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9823:UTS2B
gene id: 9823:UTS2B
uniprot id: A0A4X1UC97
uniprot id: A0A8D1BLV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9823:ID3
gene id: 9823:ID3
uniprot id: A0A8D0J093
uniprot id: B3W6M8
names: Subcellular Location Annotation
messages: Nucleus

9823:IRF7
gene id: 9823:IRF7
uniprot id: A0A4X1VZ72
uniprot id: A0ZVR0
names: Subcellular Location Annotation
messages: Nucleus

9823:ANAPC5
gene id: 9823:ANAPC5
uniprot id: A0A480VKC1
uniprot id: A0A8D1HTT2
uniprot id: F1RNP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9823:LOC100516039
gene id: 9823:LOC100516039
uniprot id: A0A286ZXS6
uniprot id: A0A8D1UP34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:SDC1
gene id: 9823:SDC1
uniprot id: A0A4X1U4Q2
uniprot id: K7GNF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9823:MAS1
gene id: 9823:MAS1
uniprot id: A0A480DGN1
uniprot id: A0A4X1VX06
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:TMEM126A
gene id: 9823:TMEM126A
uniprot id: A0A8D1UPS6
uniprot id: I3LJK4
names: Subcellular Location Annotation
messages: Membrane

9823:RBPMS2
gene id: 9823:RBPMS2
uniprot id: A0A4X1TZ36
uniprot id: F1S0B2
names: Subcellular Location Annotation
messages: Cytoplasm

9823:SMAD7
gene id: 9823:SMAD7
uniprot id: A0A4X1UKJ4
uniprot id: A0A4X1UM82
uniprot id: A0A8D1CF02
uniprot id: F1CK19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9823:LOC100516933
gene id: 9823:LOC100516933
uniprot id: F1RRP5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PROC
gene id: 9823:PROC
uniprot id: A0A8D1AWZ7
uniprot id: A0A8D1XN75
uniprot id: I3LRJ4
uniprot id: Q9GLP2
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Calcium also binds, with stronger affinity to another site, beyond the GLA domain. This GLA-independent binding site is necessary for the recognition of the thrombin-thrombomodulin complex.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasma; synthesized in the liver.
messages: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
messages: Secreted
messages: Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
messages: The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.

9823:LOC100516817
gene id: 9823:LOC100516817
uniprot id: A0A5G2RCM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:APPL1
gene id: 9823:APPL1
uniprot id: A0A4X1VJU7
uniprot id: B5LX40
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9823:GABRA6
gene id: 9823:GABRA6
uniprot id: A0A4X1TXJ7
uniprot id: A0A8D1XUC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:LAMTOR5
gene id: 9823:LAMTOR5
uniprot id: Q66X52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway.
messages: Belongs to the LAMTOR5 family.
messages: Homodimer. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator. Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1.
messages: Lysosome
messages: cytosol

9823:PLPP3
gene id: 9823:PLPP3
uniprot id: A0A287ABN3
uniprot id: A0A4X1WB06
uniprot id: A0A8D1VL56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9823:SMIM7
gene id: 9823:SMIM7
uniprot id: A0A4X1UT77
uniprot id: A0A5G2QQ31
names: Similarity
messages: Belongs to the SMIM7 family.

9823:CDC20
gene id: 9823:CDC20
uniprot id: Q5H7C0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C) (By similarity).
messages: Belongs to the WD repeat CDC20/Fizzy family.
messages: Component of a complex with CDC20, CDC27, SPATC1 and TUBG1 (By similarity). Interacts with NEUROD2 (By similarity). Interacts with dimeric MAD2L1 in its closed conformation form (By similarity). Interacts with BUB1B (By similarity). The phosphorylated form interacts with APC/C (By similarity). Interacts with NINL (By similarity). May interact with MAD2L2 (By similarity). Interacts with CDK5RAP2 (By similarity). Interacts with SIRT2 (By similarity). Interacts with isoform 1 of NEK2 (By similarity). Interacts with HSF1 (via phosphorylated form); this interaction occurs in mitosis in a MAD2L1-dependent manner and prevents PLK1-stimulated degradation of HSF1 by blocking the recruitment of the SCF(BTRC) ubiquitin ligase complex (By similarity). Interacts (via the N-terminal substrate-binding domain) with FBXO5 (By similarity). Interacts with CCNF (By similarity).
messages: Dephosphorylated by CTDP1.
messages: Involved in the metaphase/anaphase transition of cell cycle (By similarity). Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity).
messages: Phosphorylated during mitosis (By similarity). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161 (By similarity). Phosphorylated by NEK2 (By similarity).
messages: Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C. Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex (By similarity).
messages: centrosome
messages: kinetochore
messages: spindle pole

9823:DDX21
gene id: 9823:DDX21
uniprot id: A0A8D1LWS8
uniprot id: F1SUG7
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9823:FAM46C
gene id: 9823:FAM46C
uniprot id: A0A076V3E9
uniprot id: A0A287AN43
uniprot id: A0A4X1STW6
names: Similarity
messages: Belongs to the TENT family.

9823:LOC100624541
gene id: 9823:LOC100624541
uniprot id: A0A287ADU1
uniprot id: A0A8D1URL0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:CSN1S1
gene id: 9823:CSN1S1
uniprot id: B5KLC3
uniprot id: P39035
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9823:CCR1
gene id: 9823:CCR1
uniprot id: A0A8D0TYM0
uniprot id: Q6YST0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9823:WNT3A
gene id: 9823:WNT3A
uniprot id: A0A480RFN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:PROK1
gene id: 9823:PROK1
uniprot id: D3K5J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9823:MTX3
gene id: 9823:MTX3
uniprot id: A0A287A0B1
uniprot id: A0A287AMT3
uniprot id: A0A8D0IME5
uniprot id: A0A8D0IRT4
uniprot id: A0A8D0S3V5
uniprot id: I3LRA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:CCDC181
gene id: 9823:CCDC181
uniprot id: A0A287AG09
uniprot id: A0A4X1UZ97
uniprot id: A0A8D1NJV2
uniprot id: A0A8D2BXT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton

9823:KDSR
gene id: 9823:KDSR
uniprot id: A0A4X1TPM8
uniprot id: F1SMW5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:P2RX7
gene id: 9823:P2RX7
uniprot id: A0A4X1U6Q1
uniprot id: A0A8D1CA78
uniprot id: F1RNN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9823:B2M
gene id: 9823:B2M
uniprot id: B2NJ26
uniprot id: Q07717
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

9823:LNPK
gene id: 9823:LNPK
uniprot id: A0A8D1AU79
uniprot id: A0A8D1I247
uniprot id: A0A8D1I4D5
uniprot id: A0A8D1XLW7
uniprot id: I3LG37
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9823:N4BP3
gene id: 9823:N4BP3
uniprot id: A0A8D0W086
uniprot id: F1S3E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Vesicle
messages: dendrite

9823:PGM3
gene id: 9823:PGM3
uniprot id: F1RQM2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.
messages: Inhibited by Mn(2+), Cd(2+), Zn(2+), Cu(2+) and Be(2+).

9823:C4BPB
gene id: 9823:C4BPB
uniprot id: A0A4X1UPT7
uniprot id: F1S0J3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ELN
gene id: 9823:ELN
uniprot id: A0A097ZMY9
uniprot id: A0A8D1EJI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elastin family.
messages: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle.
messages: extracellular matrix

9823:CAMK2N1
gene id: 9823:CAMK2N1
uniprot id: A0A8D0MKN5
uniprot id: I3LQ15
names: Similarity
messages: Belongs to the CAMK2N family.

9823:CDH1
gene id: 9823:CDH1
uniprot id: C6EVT4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9823:SPESP1
gene id: 9823:SPESP1
uniprot id: D5K893
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPESP1 family.
messages: Involved in fertilization ability of sperm.
messages: acrosome

9823:FOXO3
gene id: 9823:FOXO3
uniprot id: B5UA80
names: Subcellular Location Annotation
messages: Nucleus

9823:SSR2
gene id: 9823:SSR2
uniprot id: A0A4X1W122
uniprot id: A0A8D0VQG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9823:SMU1
gene id: 9823:SMU1
uniprot id: A0A4X1UMT8
uniprot id: A0A8D2BV52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9823:BORCS8
gene id: 9823:BORCS8
uniprot id: A0A4X1U341
uniprot id: A0A4X1U346
uniprot id: A0A4X1U5U8
uniprot id: A0A8D2C4W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

9823:LSM1
gene id: 9823:LSM1
uniprot id: A0A4X1VW00
uniprot id: A0A8D2BW03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9823:LOC100738003
gene id: 9823:LOC100738003
uniprot id: A0A286ZX28
uniprot id: A0A8D1Z837
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9823:AMELY
gene id: 9823:AMELY
uniprot id: P45561
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: A number of other isoforms are produced by carboxy-terminal processing.
messages: Belongs to the amelogenin family.
messages: Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.
messages: extracellular matrix

9823:NKAIN1
gene id: 9823:NKAIN1
uniprot id: A0A4X1VU05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9823:DBX1
gene id: 9823:DBX1
uniprot id: A0A8D0T972
uniprot id: F1SFY4
names: Subcellular Location Annotation
messages: Nucleus

9823:TRDMT1
gene id: 9823:TRDMT1
uniprot id: C5HA00
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9823:SDHAF1
gene id: 9823:SDHAF1
uniprot id: A0A4X1TCK8
uniprot id: F1RLD9
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

9823:SORD
gene id: 9823:SORD
uniprot id: A0A480UJV9
uniprot id: A0A4X1VDW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 1 or 2 Zn(2+) ions per subunit.
messages: Homotetramer.
messages: Mitochondrion membrane
messages: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.
messages: flagellum

9823:LOC100521949
gene id: 9823:LOC100521949
uniprot id: A0A5G2QHN6
uniprot id: A0A8D1DQB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100524972
gene id: 9823:LOC100524972
uniprot id: A0A8D2C485
names: Similarity
messages: Belongs to the MS4A family.

9823:NOL11
gene id: 9823:NOL11
uniprot id: A0A480K148
uniprot id: A0A4X1SX68
names: Subcellular Location Annotation
messages: nucleolus

9823:FMO2
gene id: 9823:FMO2
uniprot id: A0A4X1V653
uniprot id: F1S6B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9823:C4H1orf52
gene id: 9823:C4H1orf52
uniprot id: A0A4X1UEZ7
uniprot id: F1SEW8
names: Similarity
messages: Belongs to the UPF0690 family.

9823:MAPRE2
gene id: 9823:MAPRE2
uniprot id: A0A8D0QTV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9823:CDKN1A
gene id: 9823:CDKN1A
uniprot id: A0A8D1YE25
names: Similarity
messages: Belongs to the CDI family.

9823:PARPBP
gene id: 9823:PARPBP
uniprot id: A0A4X1T551
uniprot id: A0A5G2QYX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9823:ARFGEF1
gene id: 9823:ARFGEF1
uniprot id: A0A8D0UK54
uniprot id: K7GSM4
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9823:HAP1
gene id: 9823:HAP1
uniprot id: A0A8D0Z706
uniprot id: F1S0M4
names: Subcellular Location Annotation
messages: Early endosome
messages: Mitochondrion

9823:AQP11
gene id: 9823:AQP11
uniprot id: A8WCF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Cell membrane
messages: Membrane

9823:LAPTM5
gene id: 9823:LAPTM5
uniprot id: A0A8D0JB29
uniprot id: I3L9C0
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9823:PYGM
gene id: 9823:PYGM
uniprot id: A0A8D0PGJ5
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9823:MAT2A
gene id: 9823:MAT2A
uniprot id: A0A8D2BKN0
uniprot id: D0G777
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9823:SEMA4C
gene id: 9823:SEMA4C
uniprot id: A0A4X1VYH6
uniprot id: F1STD1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ALG8
gene id: 9823:ALG8
uniprot id: A0A480XBR2
uniprot id: A0A8D0Z3W3
uniprot id: A0A8D2CCL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:ATL3
gene id: 9823:ATL3
uniprot id: A0A5G2QCA3
uniprot id: A0A8D0P6F9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9823:NADK2
gene id: 9823:NADK2
uniprot id: A0A287BBX3
uniprot id: A0A4X1TAZ0
uniprot id: A0A4X1TCS4
uniprot id: F1SNB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

9823:LOC100622735
gene id: 9823:LOC100622735
uniprot id: A0A4X1TXB0
uniprot id: A0A5G2RK81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CCNB2
gene id: 9823:CCNB2
uniprot id: A0A8D0J6H9
uniprot id: A9ZPH4
names: Similarity
messages: Belongs to the cyclin family.

9823:MCOLN2
gene id: 9823:MCOLN2
uniprot id: A0A4X1UZZ6
uniprot id: A0A8D0QVD8
uniprot id: F1SAG5
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9823:SLU7
gene id: 9823:SLU7
uniprot id: A0A8D1NNE9
uniprot id: F1RR54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9823:ANKS4B
gene id: 9823:ANKS4B
uniprot id: A0A8D1ZFU2
uniprot id: F1RPC7
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9823:PSMF1
gene id: 9823:PSMF1
uniprot id: A0A4X1SLZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

9823:ITGB3
gene id: 9823:ITGB3
uniprot id: A0A4X1T8N7
uniprot id: Q95JH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9823:SLC11A1
gene id: 9823:SLC11A1
uniprot id: O77741
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

9823:LOC100623188
gene id: 9823:LOC100623188
uniprot id: A0A4X1VHE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ARMCX3
gene id: 9823:ARMCX3
uniprot id: A0A287BGW5
uniprot id: A0A8D1AJX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9823:XRCC1
gene id: 9823:XRCC1
uniprot id: F1RMW4
names: Subcellular Location Annotation
messages: Nucleus

9823:VIPR1
gene id: 9823:VIPR1
uniprot id: A0A4X1TLQ5
uniprot id: D9IWB9
uniprot id: D9IWC2
uniprot id: D9IWC4
uniprot id: Q28992
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane
messages: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).

9823:CTBP2
gene id: 9823:CTBP2
uniprot id: A0A287AIK8
uniprot id: A0A8D1IHI9
uniprot id: A0A8D1ZZ14
uniprot id: F1SDN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9823:GPN3
gene id: 9823:GPN3
uniprot id: A0A8D1D1R8
uniprot id: F1RNN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9823:SERP1
gene id: 9823:SERP1
uniprot id: A0A286ZIJ7
uniprot id: A0A4X1SYZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9823:LOC100155779
gene id: 9823:LOC100155779
uniprot id: A0A8D1D055
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GTPBP8
gene id: 9823:GTPBP8
uniprot id: A0A481BFS8
uniprot id: A0A8D1PVH1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

9823:LOC100156127
gene id: 9823:LOC100156127
uniprot id: A0A8D0X5U9
uniprot id: F2Z584
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:SLC22A4
gene id: 9823:SLC22A4
uniprot id: A0A287ABQ9
uniprot id: A0A4X1URG8
uniprot id: C0MP43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9823:RPS5
gene id: 9823:RPS5
uniprot id: A0A4X1W3K3
uniprot id: F2Z5E6
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9823:GDPGP1
gene id: 9823:GDPGP1
uniprot id: A0A4X1TY40
uniprot id: A0A8W4FPW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

9823:CNIH2
gene id: 9823:CNIH2
uniprot id: A0A4X1TQN2
uniprot id: A0A4X1TVN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9823:IFN-OMEGA-3
gene id: 9823:IFN-OMEGA-3
uniprot id: A0A4X1WC26
uniprot id: Q29085
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:ANXA7
gene id: 9823:ANXA7
uniprot id: A0A4X1T2U3
uniprot id: A0A4X1T3V0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9823:TMEM129
gene id: 9823:TMEM129
uniprot id: A0A287BLX0
uniprot id: A0A4X1T2H5
uniprot id: A0A4X1T2I2
uniprot id: F1S8S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9823:LRP12
gene id: 9823:LRP12
uniprot id: A0A286ZXB4
uniprot id: A0A8D1ABC0
uniprot id: I7CEB2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DCT
gene id: 9823:DCT
uniprot id: Q4R1H1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tyrosinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Forms an OPN3-dependent complex with TYR in response to blue light in melanocytes.
messages: Glycosylated.
messages: Melanosome
messages: Melanosome membrane
messages: Plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).

9823:GMPPA
gene id: 9823:GMPPA
uniprot id: A0A480QK53
uniprot id: A0A8D1MDM2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9823:PPP1R3B
gene id: 9823:PPP1R3B
uniprot id: A0A5G2QRJ8
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9823:KCNN4
gene id: 9823:KCNN4
uniprot id: A0A4X1W3A5
uniprot id: Q8WMG4
names: Subcellular Location Annotation
messages: Membrane

9823:PQLC1
gene id: 9823:PQLC1
uniprot id: A0A287AKV6
uniprot id: A0A287BEV0
uniprot id: A0A4X1SCZ2
uniprot id: A0A4X1SDE9
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100516454
gene id: 9823:LOC100516454
uniprot id: A0A8D1FAF9
uniprot id: F1S808
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100513601
gene id: 9823:LOC100513601
uniprot id: D6C4F8
names: Similarity
messages: Belongs to the MHC class I family.

9823:HCST
gene id: 9823:HCST
uniprot id: A0A8D0NFP4
uniprot id: Q9GJR5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DAP10 family.
messages: Expressed predominantly in lymphohematopoietic tissues.
messages: Homodimer; Disulfide-linked. Heterohexamer composed of four subunits of HCST/DAP10 and two subunits of KLRK1. Interacts (via transmembrane domain) with KLRK1 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Interacts with PIK3R1 and GRB2. Interacts with CLEC5A. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP (By similarity). Interacts with KLRK1. Interacts with CD300H (By similarity).
messages: Membrane
messages: O-glycosylated.
messages: Phosphorylated; PIK3R1 and GRB2 associate specifically with tyrosine-phosphorylated HCST.
messages: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity).

9823:GAPDH
gene id: 9823:GAPDH
uniprot id: A0A481CCJ1
uniprot id: P00355
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Glyceraldehyde-3-phosphate dehydrogenase activity is inhibited by fumarate, via the formation of S-(2-succinyl)cysteine residues.
messages: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
messages: Homotetramer (By similarity). Interacts with TPPP; the interaction is direct (By similarity). Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules. Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS1. Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)). Component of the GAIT complex. Interacts with FKBP6; leading to inhibit GAPDH catalytic activity. Interacts with TRAF2, promoting TRAF2 ubiquitination. Interacts with TRAF3, promoting TRAF3 ubiquitination (By similarity).
messages: Homotetramer.
messages: ISGylated.
messages: Nucleus
messages: Oxidative stress can promote the formation of high molecular weight disulfide-linked GAPDH aggregates, through a process called nucleocytoplasmic coagulation.
messages: S-nitrosylation of Cys-150 leads to interaction with SIAH1, followed by translocation to the nucleus S-nitrosylation of Cys-245 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity (By similarity).
messages: Sulfhydration at Cys-150 increases catalytic activity.
messages: The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
messages: cytoskeleton
messages: cytosol

9823:MTO1
gene id: 9823:MTO1
uniprot id: A0A4X1U0H2
uniprot id: F1RQG8
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

9823:RETNLB
gene id: 9823:RETNLB
uniprot id: A0A4X1SQJ0
uniprot id: A7XNM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9823:LRP8
gene id: 9823:LRP8
uniprot id: A0A286ZZZ1
uniprot id: A0A480VEB1
uniprot id: A0A8D1I3D9
uniprot id: A0A8D1IE42
uniprot id: A0A8D2A9L8
uniprot id: A0A8D2CIE8
uniprot id: E7CXS0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CSNK2A1
gene id: 9823:CSNK2A1
uniprot id: A0A4X1SPI6
uniprot id: A0A8D1BMU9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:SELE
gene id: 9823:SELE
uniprot id: P98110
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Cell-surface glycoprotein having a role in immunoadhesion (PubMed:7526854). Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis (By similarity).
messages: Important in acute cellular allograft rejection and probably also in xenograft rejection.
messages: Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction.

9823:NIPAL2
gene id: 9823:NIPAL2
uniprot id: A0A4X1U046
uniprot id: A0A5G2QAM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9823:CNFN
gene id: 9823:CNFN
uniprot id: A0A4X1SJA2
uniprot id: A0A4X1SJI1
uniprot id: F1RGI5
names: Similarity
messages: Belongs to the cornifelin family.

9823:EXO5
gene id: 9823:EXO5
uniprot id: A0A4X1VIA1
uniprot id: F1SCQ8
names: Similarity
messages: Belongs to the EXO5 family.

9823:STARD3
gene id: 9823:STARD3
uniprot id: A0A4X1UIX1
uniprot id: A0A8D0SY40
uniprot id: B8XSJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9823:OLR1
gene id: 9823:OLR1
uniprot id: Q9TTK7
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70 (By similarity).
messages: Membrane raft
messages: N-glycosylated.
messages: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).
messages: Secreted
messages: The C-type lectin domain mediates the recognition and binding of oxLDL.
messages: The cytoplasmic region is required for subcellular sorting on the cell surface.

9823:LOC106509349
gene id: 9823:LOC106509349
uniprot id: A0A8D0IBH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CCL19
gene id: 9823:CCL19
uniprot id: A0A8D1GKZ3
uniprot id: D0Z5W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:STEAP4
gene id: 9823:STEAP4
uniprot id: D0EX57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9823:SEPT8
gene id: 9823:SEPT8
uniprot id: A0A287AWW1
uniprot id: A0A4X1UVE4
uniprot id: A0A4X1UX86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9823:F2R
gene id: 9823:F2R
uniprot id: A7UGA9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:TRIM15
gene id: 9823:TRIM15
uniprot id: Q9TSW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis. Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2. Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN. Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS. Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm. Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs).
messages: Interacts with paxillin/PXN; this interaction recruits TRIM15 to focal adhesions. Interacts with TRIM8; this interaction prevents TRIM8 cytoplasmic translocation.
messages: Nucleus
messages: focal adhesion

9823:PTPN18
gene id: 9823:PTPN18
uniprot id: A0A8D1IG32
uniprot id: A0A8D1IGD5
uniprot id: A0A8D1L2C3
uniprot id: F1RXX2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.

9823:FEZ2
gene id: 9823:FEZ2
uniprot id: A0A8D1WLV8
uniprot id: A0A8D2BSS3
names: Similarity
messages: Belongs to the zygin family.

9823:SLC10A4
gene id: 9823:SLC10A4
uniprot id: A0A4X1UKK1
uniprot id: F1SEA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9823:TEX13B
gene id: 9823:TEX13B
uniprot id: F1RXI9
names: Similarity
messages: Belongs to the TEX13 family.

9823:BTBD10
gene id: 9823:BTBD10
uniprot id: A0A287BN22
uniprot id: A0A480LCN3
uniprot id: A0A8D1G5T4
names: Subcellular Location Annotation
messages: Cytoplasm

9823:GPT
gene id: 9823:GPT
uniprot id: A0A8D0MH20
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9823:AGTRAP
gene id: 9823:AGTRAP
uniprot id: A0A8D0MEF1
uniprot id: A0A8D1R801
names: Subcellular Location Annotation
messages: Membrane

9823:RAB3GAP1
gene id: 9823:RAB3GAP1
uniprot id: A0A8D1V3B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm
messages: Endoplasmic reticulum

9823:VPS53
gene id: 9823:VPS53
uniprot id: A0A480L6G7
uniprot id: A0A8D2A5Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9823:ANP32A
gene id: 9823:ANP32A
uniprot id: A0A4X1T6H6
uniprot id: A0A8D1HIP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9823:PPP1R15A
gene id: 9823:PPP1R15A
uniprot id: A0A8D1S8R8
names: Similarity
messages: Belongs to the PPP1R15 family.

9823:STAC2
gene id: 9823:STAC2
uniprot id: A0A480MPY7
uniprot id: A0A4X1UHE5
uniprot id: A0A8D1BK21
uniprot id: F1RWK9
names: Subcellular Location Annotation
messages: sarcolemma

9823:SEC62
gene id: 9823:SEC62
uniprot id: A7WLH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:CLGN
gene id: 9823:CLGN
uniprot id: A0A4X1VJ97
uniprot id: A0A8D0V695
uniprot id: A0A8D0YFV6
names: Similarity
messages: Belongs to the calreticulin family.

9823:FGF19
gene id: 9823:FGF19
uniprot id: A0A287B3V5
uniprot id: A0A4X1SJA6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:P2RY2
gene id: 9823:P2RY2
uniprot id: Q5YA25
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in heart, kidney, intestine, skeletal muscle and adrenal gland.
messages: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP > ATP.
messages: Up-regulated in stented coronary arteries (at protein level).

9823:HRH4
gene id: 9823:HRH4
uniprot id: A0A4X1VP78
uniprot id: Q8WNV9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:AURKB
gene id: 9823:AURKB
uniprot id: Q9N0X0
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated at Lys-215 by KAT5 at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis.
messages: Activity is greatly increased when AURKB is within the CPC complex. In particular, AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between HASPIN and AURKB contributes to CPC localization.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: Chromosome
messages: Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist. Associates with RACGAP1 during M phase. Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPTIN1, SIRT2 and TACC1. Interacts with SPDYC; this interaction may be required for proper localization of active, Thr-232-phosphorylated AURKB form during prometaphase and metaphase. Interacts with p53/TP53. Interacts (via the middle kinase domain) with NOC2L (via the N- and C-terminus domains). Interacts with TTC28 (By similarity). Interacts with RNF2/RING1B (By similarity).
messages: Midbody
messages: Nucleus
messages: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (By similarity). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at …
messages: The phosphorylation of Thr-232 requires the binding to INCENP and occurs by means of an autophosphorylation mechanism. Thr-232 phosphorylation is indispensable for the AURKB kinase activity.
messages: Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. Deubiquitinated by USP35; inhibiting CDH1-mediated degradation of AURKB.
messages: centromere
messages: kinetochore
messages: spindle

9823:LRRC8B
gene id: 9823:LRRC8B
uniprot id: A0A480EQW0
uniprot id: A0A8D0YMX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9823:GLIS2
gene id: 9823:GLIS2
uniprot id: A0A5G2QHY8
uniprot id: A0A8D1EAU5
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9823:SUPT5H
gene id: 9823:SUPT5H
uniprot id: A0A8D1JAK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9823:POLM
gene id: 9823:POLM
uniprot id: A0A4X1UIK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
messages: Nucleus

9823:AP3S2
gene id: 9823:AP3S2
uniprot id: A0A4X1TYY4
uniprot id: A0A8D0LNH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9823:HOXA13
gene id: 9823:HOXA13
uniprot id: D3K5K0
names: Subcellular Location Annotation
messages: Nucleus

9823:NT5E
gene id: 9823:NT5E
uniprot id: A0A8D0X3A8
uniprot id: K7GSR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9823:ATL2
gene id: 9823:ATL2
uniprot id: A0A287AWD2
uniprot id: A0A8D1Y4M8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9823:LOC106504546
gene id: 9823:LOC106504546
uniprot id: A0A8D0PIK8
names: Similarity
messages: Belongs to the serpin family.

9823:RPS24
gene id: 9823:RPS24
uniprot id: A0A4X1SJK8
uniprot id: A0A4X1V4V5
uniprot id: A0A8D0T6Q4
uniprot id: A0A8D1C2A7
uniprot id: A0A8D1E7C5
uniprot id: A0A8D1UE81
uniprot id: A0A8W4FAW3
uniprot id: I3LJP6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

9823:IFN-DELTA-3
gene id: 9823:IFN-DELTA-3
uniprot id: A0A8D1XCN5
uniprot id: C8CKB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:VPS26B
gene id: 9823:VPS26B
uniprot id: A0A4X1V9L8
uniprot id: B6EAV3
names: Similarity
messages: Belongs to the VPS26 family.

9823:HADHA
gene id: 9823:HADHA
uniprot id: Q29554
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme (By similarity). Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear (By similarity). The mitochondrial trifunctional enzyme interacts with MTLN (By similarity).
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity. Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity. It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP. Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9823:CLDN20
gene id: 9823:CLDN20
uniprot id: C3VMW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:PDCD5
gene id: 9823:PDCD5
uniprot id: A0A481D4P9
uniprot id: A0A4X1TUT8
names: Similarity
messages: Belongs to the PDCD5 family.

9823:ESF1
gene id: 9823:ESF1
uniprot id: A0A4X1UWP8
uniprot id: F1SBJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

9823:B4GALT3
gene id: 9823:B4GALT3
uniprot id: A0A4X1VRJ3
uniprot id: A0A8D0NVV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9823:IGF2BP2
gene id: 9823:IGF2BP2
uniprot id: A0A4X1UIF2
uniprot id: A0A8D1PKK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9823:MCT7
gene id: 9823:MCT7
uniprot id: Q9N2D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family. Tryptase subfamily.
messages: Homotetramer.
messages: Secreted
messages: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.

9823:CACUL1
gene id: 9823:CACUL1
uniprot id: A0A4X1SY46
names: Similarity
messages: Belongs to the cullin family.

9823:GPR6
gene id: 9823:GPR6
uniprot id: A0A8D0RC88
uniprot id: A0A8D0YAT5
uniprot id: G4VXN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:LOC100152147
gene id: 9823:LOC100152147
uniprot id: A0A4X1SQ02
uniprot id: A0A8W4F8L3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:IRF8
gene id: 9823:IRF8
uniprot id: A0A4X1T8P1
uniprot id: Q6T5D3
names: Subcellular Location Annotation
messages: Nucleus

9823:PEX3
gene id: 9823:PEX3
uniprot id: A0A287B530
uniprot id: A0A287B8M9
uniprot id: A0A8D0I4M1
uniprot id: A0A8D1KXF0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9823:KCNQ5
gene id: 9823:KCNQ5
uniprot id: A0A287BH80
uniprot id: A0A8D1CA91
uniprot id: A0A8D1CN88
uniprot id: F1RTS6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:SLC35F6
gene id: 9823:SLC35F6
uniprot id: A0A8D1GJ74
uniprot id: F1SDQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9823:FAM58A
gene id: 9823:FAM58A
uniprot id: A0A4X1SU55
uniprot id: F1S2B1
names: Similarity
messages: Belongs to the cyclin family. Cyclin-like FAM58 subfamily.

9823:SLC26A6
gene id: 9823:SLC26A6
uniprot id: A0A4X1T129
uniprot id: A0A4X1T1L4
uniprot id: A0A5G2R765
uniprot id: Q5GM09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9823:ZC3H12C
gene id: 9823:ZC3H12C
uniprot id: A0A287AVT6
uniprot id: A0A8D0JUR4
uniprot id: A0A8D0RZ43
uniprot id: A0A8D0Y0L5
uniprot id: A0A8D1E2Z1
uniprot id: A0A8D1YY14
names: Similarity
messages: Belongs to the ZC3H12 family.

9823:IL2
gene id: 9823:IL2
uniprot id: A8D5G2
uniprot id: P26891
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9823:CLDN19
gene id: 9823:CLDN19
uniprot id: A0A4X1W7E7
uniprot id: C3VMW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:KRT74
gene id: 9823:KRT74
uniprot id: A0A4X1W662
names: Similarity
messages: Belongs to the intermediate filament family.

9823:LOC100623351
gene id: 9823:LOC100623351
uniprot id: A0A287AFW5
uniprot id: A0A4X1TBL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9823:MAGT1
gene id: 9823:MAGT1
uniprot id: A0A480WA32
uniprot id: A0A4X1W223
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LOC100626697
gene id: 9823:LOC100626697
uniprot id: A0A8D1Q3H5
uniprot id: A0ZQ13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RBP4
gene id: 9823:RBP4
uniprot id: P27485
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.
messages: Produced between days 10 and 15 of pregnancy and at day 15 found in both the peri-implantation conceptus (trophectoderm and yolk sac) and the endometrial surface and glandular epithelium. Found in allantoic fluid at day 30 of gestation.
messages: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
messages: Secreted

9823:UBXN1
gene id: 9823:UBXN1
uniprot id: I3LUD5
names: Subcellular Location Annotation
messages: Cytoplasm

9823:MYO1C
gene id: 9823:MYO1C
uniprot id: A0A8D1ZRD4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9823:MPPED2
gene id: 9823:MPPED2
uniprot id: A0A8D0R245
uniprot id: F1SGP0
names: Similarity
messages: Belongs to the UPF0046 family.

9823:LOC396790
gene id: 9823:LOC396790
uniprot id: A0A287AX70
uniprot id: A0A8D0W8T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:HRH2
gene id: 9823:HRH2
uniprot id: A0A4X1SL18
uniprot id: A0A8D1GHH8
uniprot id: I3L760
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:COPA
gene id: 9823:COPA
uniprot id: A0A8D0Q593
uniprot id: F1RJX8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9823:TSHR
gene id: 9823:TSHR
uniprot id: A0A4X1T1H2
uniprot id: Q8SPP9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Expressed in thyroide cells (at protein level).
messages: Glycosylated.
messages: Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production. Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.
messages: Lateral cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
messages: Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation.

9823:LEF1
gene id: 9823:LEF1
uniprot id: A0A286ZR78
uniprot id: A0A4X1UVU7
uniprot id: A0A4X1UVV8
uniprot id: A0A4X1UVW8
uniprot id: A0A8D0MSY6
uniprot id: B3GQS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9823:DCPS
gene id: 9823:DCPS
uniprot id: Q8MIZ3
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus
messages: The C-terminal histidine triad (HIT) motif and the N-terminal domain are required for the decapping activity. The N-terminus is necessary but not sufficient for binding cap structures.
messages: The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping scavenger activity and acts as a competitive inhibitor in vitro. Inhibited by 2,4-diaminoquinazoline.

9823:SFRP1
gene id: 9823:SFRP1
uniprot id: A0A4X1U7I6
uniprot id: K7GNP5
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:GPRASP2
gene id: 9823:GPRASP2
uniprot id: A0A4X1VZ99
uniprot id: F1RYE7
names: Similarity
messages: Belongs to the GPRASP family.

9823:MIP
gene id: 9823:MIP
uniprot id: A0A4X1W841
uniprot id: A0A8D0WE26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:KRT2
gene id: 9823:KRT2
uniprot id: A0A8D1AGQ1
uniprot id: A5A759
names: Similarity
messages: Belongs to the intermediate filament family.

9823:DYNLL1
gene id: 9823:DYNLL1
uniprot id: A0A8D0VWG4
uniprot id: D9U8D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9823:KMT5B
gene id: 9823:KMT5B
uniprot id: A0A287BNJ8
uniprot id: A0A4X1SUF7
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9823:CALCB
gene id: 9823:CALCB
uniprot id: A0A8D0M1G8
uniprot id: A6P7L6
uniprot id: A6P7L7
uniprot id: Q862B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calcitonin family.
messages: Mainly expressed in the thyroid gland and CNS. Found in the nerve cells of cerebrum, hippocampus, hypothalamus, pons/midbrain and thalamus.
messages: Secreted
messages: Stimulates cAMP production in porcine kidney cell line LLC-PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor.

9823:TRIM50
gene id: 9823:TRIM50
uniprot id: Q865W2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300 and KAT2B. HDAC6 drives TRIM50 deacetylation. Acetylation antagonizes with TRIM50 ubiquitination.
messages: Auto-ubiquitinated.
messages: Belongs to the TRIM/RBCC family.
messages: Can form dimers and trimers. Interacts with several E2 ubiquitin-conjugating enzymes, including UBE2L6, UBE2E1, UBE2E3. No interaction with UBE2H. Interacts with BECN1. Interacts with SQSTM1. Interacts with NLRP3.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction. Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity).

9823:LOC100516783
gene id: 9823:LOC100516783
uniprot id: A0A8D1Y6J0
uniprot id: F1S6N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:STXBP1
gene id: 9823:STXBP1
uniprot id: A0A480SGV1
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9823:KIAA1324L
gene id: 9823:KIAA1324L
uniprot id: A0A480DMC3
uniprot id: A0A8D1HTB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9823:LOX
gene id: 9823:LOX
uniprot id: A0A4X1U750
uniprot id: F1RLC4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9823:LDLRAD4
gene id: 9823:LDLRAD4
uniprot id: A0A4X1VTW1
uniprot id: I3LQ52
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:PDIK1L
gene id: 9823:PDIK1L
uniprot id: A0A4X1VS38
uniprot id: A0A8D2BXR8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:STRADB
gene id: 9823:STRADB
uniprot id: A0A287BD67
uniprot id: A0A4X1VAU6
uniprot id: A0A8D0IKQ6
uniprot id: A0A8D0W4G5
uniprot id: A0A8D1J835
uniprot id: A0A8D1JE99
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9823:DDT
gene id: 9823:DDT
uniprot id: A0A4X1V3D9
uniprot id: A0A8W4FG18
names: Similarity
messages: Belongs to the MIF family.

9823:SLC22A8
gene id: 9823:SLC22A8
uniprot id: Q70BM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Expressed in kidney.
messages: Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient (By similarity). Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (Probable). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:15820748). E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange (By similarity). Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule. Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside. May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (By similarity). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS), indole acetate (IA), hippurate/N-benzoylglycine (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor)…

9823:RAD23A
gene id: 9823:RAD23A
uniprot id: A0A4X1TDA9
uniprot id: A0A8D0M863
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9823:LOC106504900
gene id: 9823:LOC106504900
uniprot id: A0A4X1TMU9
uniprot id: A0A5G2QGW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NTRK3
gene id: 9823:NTRK3
uniprot id: P24786
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and KIDINS220. Interacts with PTPRS (By similarity). Interacts with MAPK8IP3/JIP3 (By similarity).
messages: Ligand-mediated auto-phosphorylation.
messages: Membrane
messages: Preferentially in the brain, low levels in the ovaries.
messages: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

9823:SYP
gene id: 9823:SYP
uniprot id: A0A480MAK8
uniprot id: A0A4X1SYD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9823:SMO
gene id: 9823:SMO
uniprot id: A0A8D1ZBL7
uniprot id: F1SMQ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium

9823:ADM
gene id: 9823:ADM
uniprot id: P53366
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: AM and PAMP are potent hypotensive and vasodilatator agents.
messages: Belongs to the adrenomedullin family.
messages: Highly expressed in adrenal glands, lung and kidney.
messages: Secreted

9823:SERPINF1
gene id: 9823:SERPINF1
uniprot id: A0A4X1U9I7
uniprot id: Q0PM28
names: Similarity
messages: Belongs to the serpin family.

9823:OASL
gene id: 9823:OASL
uniprot id: Q53B79
names: Similarity
messages: Belongs to the 2-5A synthase family.

9823:GPR3
gene id: 9823:GPR3
uniprot id: A0A8D0NDZ4
uniprot id: F1STP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:LOC100522678
gene id: 9823:LOC100522678
uniprot id: A0A480EHC1
uniprot id: A0A4X1TWD8
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

9823:TBX18
gene id: 9823:TBX18
uniprot id: A0A8D0YZU9
uniprot id: F1S0I2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:IL2RG
gene id: 9823:IL2RG
uniprot id: Q8SQ71
names: Subcellular Location Annotation
messages: Membrane

9823:LIPT2
gene id: 9823:LIPT2
uniprot id: A0A4X1UQK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

9823:PIK3R1
gene id: 9823:PIK3R1
uniprot id: A0A4X1UM36
uniprot id: F1SKR9
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9823:RBBP5
gene id: 9823:RBBP5
uniprot id: A0A4X1UVX1
uniprot id: A0A8D0I6Q0
names: Subcellular Location Annotation
messages: Nucleus

9823:IL5
gene id: 9823:IL5
uniprot id: Q9MYM5
uniprot id: R9UCF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked. Interacts with IL5RA. Interacts with CSF2RB.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity).
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

9823:CHST2
gene id: 9823:CHST2
uniprot id: A0A8D1D956
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9823:TRIM2
gene id: 9823:TRIM2
uniprot id: A0A8D1G8G9
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9823:ITGAV
gene id: 9823:ITGAV
uniprot id: A0A4X1TWU5
uniprot id: A2RQD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9823:MMD2
gene id: 9823:MMD2
uniprot id: A0A8D0RKU5
uniprot id: F1RI48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:HTR1B
gene id: 9823:HTR1B
uniprot id: Q9GLP5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

9823:RRP15
gene id: 9823:RRP15
uniprot id: A0A480T6W5
uniprot id: A0A4X1TN88
names: Similarity
messages: Belongs to the RRP15 family.

9823:ORAI3
gene id: 9823:ORAI3
uniprot id: A0A4X1TL02
uniprot id: A0A8D0MYW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9823:OSM
gene id: 9823:OSM
uniprot id: A0A480V8J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: Secreted

9823:LOC100522787
gene id: 9823:LOC100522787
uniprot id: A0A480T933
uniprot id: A0A4X1U2L2
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:TRAPPC2L
gene id: 9823:TRAPPC2L
uniprot id: A0A8D0XRF6
uniprot id: A0A8D1MD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9823:MMP12
gene id: 9823:MMP12
uniprot id: A6H560
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9823:IZUMO4
gene id: 9823:IZUMO4
uniprot id: A0A287BKY5
uniprot id: A0A8D0R5M2
names: Similarity
messages: Belongs to the Izumo family.

9823:GCNT3
gene id: 9823:GCNT3
uniprot id: A0A8D1HVQ7
uniprot id: F1S070
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9823:KIF2B
gene id: 9823:KIF2B
uniprot id: A0A8D1QPI7
uniprot id: F1RSG0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:PPAG3
gene id: 9823:PPAG3
uniprot id: Q9BGG5
names: Similarity
messages: Belongs to the peptidase A1 family.

9823:MYO1E
gene id: 9823:MYO1E
uniprot id: A0A4X1TQX9
uniprot id: A0A8D1B5A4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9823:LOC100155138
gene id: 9823:LOC100155138
uniprot id: A0A480KVX2
uniprot id: A0A8D0MRN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9823:SPEF2
gene id: 9823:SPEF2
uniprot id: Q2IA00
names: Disease Annotation
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Defects in SPEF2 are a cause of immotile short-tail sperm defects, an autosomal recessive disease only found in the Finnish Yorkshire pig population (PubMed:16549801, PubMed:17610085, PubMed:19889948). It specifically affects the axoneme structure of sperm flagella, whereas cilia in other tissues appear unaffected (PubMed:16549801, PubMed:17610085, PubMed:19889948). Sperm flagella are short and malformed, with disorganized mitochondria and loss or disorganization of the outer fibrous sheath (PubMed:19889948).
messages: Golgi apparatus
messages: Interacts (via C-terminus) with IFT20. Interacts with DYNC1I2.
messages: Predominantly expressed in ciliated tissues. Mainly expressed in testis, followed by trachea. Also expressed at lower level in lung, kidney and liver.
messages: Required for correct axoneme development in spermatozoa (PubMed:16549801, PubMed:19889948). Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation (By similarity).
messages: flagellum

9823:CTNNBL1
gene id: 9823:CTNNBL1
uniprot id: I1SNT7
names: Subcellular Location Annotation
messages: Nucleus

9823:EIF3J
gene id: 9823:EIF3J
uniprot id: A0A4X1VCB2
uniprot id: A0A5G2R3H6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9823:ANXA4
gene id: 9823:ANXA4
uniprot id: D0G0C5
uniprot id: P08132
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
messages: Monomer.
messages: Seems to bind one calcium ion with high affinity.
messages: Zymogen granule membrane

9823:GABRA4
gene id: 9823:GABRA4
uniprot id: I3LIV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:HSD17B2
gene id: 9823:HSD17B2
uniprot id: D0G6Y1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:PAQR5
gene id: 9823:PAQR5
uniprot id: A0A287AB20
uniprot id: A0A8D0JW25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:MRPL1
gene id: 9823:MRPL1
uniprot id: A0A4X1STH0
uniprot id: A0A8W4FN44
names: Subcellular Location Annotation
messages: Mitochondrion

9823:NPG4
gene id: 9823:NPG4
uniprot id: P51525
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria.
messages: Secreted

9823:NHP2
gene id: 9823:NHP2
uniprot id: A0A287BMH8
uniprot id: A0A4X1VXU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9823:AQP4
gene id: 9823:AQP4
uniprot id: A8V978
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:HGF
gene id: 9823:HGF
uniprot id: A0A287BRN0
uniprot id: A0A8D0J077
uniprot id: A0A8D1PS51
uniprot id: F1SB93
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

9823:TRAPPC13
gene id: 9823:TRAPPC13
uniprot id: A0A480JZZ9
uniprot id: A0A480QEF3
uniprot id: A0A480VBA9
uniprot id: A0A8D1NNJ7
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9823:PLAA
gene id: 9823:PLAA
uniprot id: A0A4X1WDK2
uniprot id: A0A5G2R9S8
uniprot id: A0A8D0I537
uniprot id: A0A8D1F343
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

9823:SLC31A2
gene id: 9823:SLC31A2
uniprot id: A0A4X1V5L2
uniprot id: A0A4X1V6N4
uniprot id: A0A8D0HVW7
uniprot id: A0A8D1RGE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9823:FBXL5
gene id: 9823:FBXL5
uniprot id: A0A8D1CBI3
uniprot id: F1S5E2
names: Subcellular Location Annotation
messages: perinuclear region

9823:ATP6V1E1
gene id: 9823:ATP6V1E1
uniprot id: A0A4X1UEG2
uniprot id: K9J4U3
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9823:ULK3
gene id: 9823:ULK3
uniprot id: A0A4X1TNJ8
uniprot id: A0A8D0LZB7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:GAST
gene id: 9823:GAST
uniprot id: P01351
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted
messages: Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.

9823:CLP1
gene id: 9823:CLP1
uniprot id: A0A286ZKE4
uniprot id: A0A4X1VQD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9823:LEAP2
gene id: 9823:LEAP2
uniprot id: Q8MJ79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9823:SEPT4
gene id: 9823:SEPT4
uniprot id: A0A173G6G4
uniprot id: A0A8D0J0X7
uniprot id: A0A8D0MUH8
uniprot id: A0A8D0MVB3
uniprot id: A0A8D1WFP4
uniprot id: F1RRN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9823:OSTC
gene id: 9823:OSTC
uniprot id: A0A4X1UWE1
uniprot id: A0A8D0V835
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9823:GPAM
gene id: 9823:GPAM
uniprot id: A0A480SGQ5
uniprot id: F1S5L4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9823:LOC100511804
gene id: 9823:LOC100511804
uniprot id: A0A4X1UKN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PEX19
gene id: 9823:PEX19
uniprot id: A0A8D1EBC5
uniprot id: A0A8D1LIF2
uniprot id: I3LRG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9823:SOSTDC1
gene id: 9823:SOSTDC1
uniprot id: A0A8D1JVZ7
uniprot id: F1SEJ1
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ALDH3A1
gene id: 9823:ALDH3A1
uniprot id: A0A4X1SZM1
uniprot id: F1SDC4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9823:SAR1B
gene id: 9823:SAR1B
uniprot id: Q5PYH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: Endoplasmic reticulum membrane
messages: GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity). Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (By similarity).
messages: Golgi stack membrane
messages: Homodimer. Binds PREB. Part of the COPII coat complex. Binds to the cytoplasmic tails of target proteins in the endoplasmic reticulum (By similarity). Interacts with SURF4 (By similarity).

9823:KPNA5
gene id: 9823:KPNA5
uniprot id: A0A4X1TD58
uniprot id: A0A8D0P4F6
uniprot id: F1RTU5
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9823:GPX1
gene id: 9823:GPX1
uniprot id: Q8MJ14
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutathione peroxidase family.
messages: Cytoplasm
messages: During periods of oxidative stress, Sec-52 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.
messages: Homotetramer. Interacts with MIEN1 (By similarity).
messages: Protects the hemoglobin in erythrocytes from oxidative breakdown. In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism.

9823:LOC100521247
gene id: 9823:LOC100521247
uniprot id: A0A5G2QT90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100525529
gene id: 9823:LOC100525529
uniprot id: A0A8D1EG14
uniprot id: F1RNE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:APCS
gene id: 9823:APCS
uniprot id: O19063
names: Cofactor
names: Disease Annotation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
messages: Secreted

9823:TRIM21
gene id: 9823:TRIM21
uniprot id: A0A8D0SDP5
uniprot id: C7E3P9
names: Subcellular Location Annotation
messages: Cytoplasm

9823:TM9SF3
gene id: 9823:TM9SF3
uniprot id: A0A4X1UB50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9823:PPP1R21
gene id: 9823:PPP1R21
uniprot id: A0A481CNM0
uniprot id: A0A8D1J0A5
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9823:ACTRT3
gene id: 9823:ACTRT3
uniprot id: A0A480DMR3
uniprot id: A0A4X1VEG6
names: Similarity
messages: Belongs to the actin family.

9823:CYSTM1
gene id: 9823:CYSTM1
uniprot id: A0A286ZTX5
uniprot id: A0A4X1SDG5
names: Similarity
messages: Belongs to the CYSTM1 family.

9823:ATG4D
gene id: 9823:ATG4D
uniprot id: A0A8D1S2M5
uniprot id: A0A8D2ADC4
uniprot id: Q684M2
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic mitochondrial targeting sequence immediately downstream of their canonical caspase cleavage sites which leads to mitochondrial import of the protein.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (By similarity). ATG4D plays a role in the autophagy-mediated neuronal homeostasis in the central nervous system. Compared to other members of the family (ATG4A, ATG4B or ATG4C), constitutes the major protein for the delipidation activity, while it promotes weak proteolytic activation of ATG8 proteins (By similarity). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (By similarity).
messages: Cytoplasm
messages: Inhibited by N-ethylmaleimide.
messages: Mitochondrion matrix
messages: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
messages: The cryptic mitochondrial transit peptide is revealed after cleavage by caspase upon oxidative stress and cell death. It acts then as a functional transit peptide, and allows the import of the cleaved protein into the mitochondria.

9823:ABHD3
gene id: 9823:ABHD3
uniprot id: A0A4X1VMW4
uniprot id: A0A8D1NYN0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9823:NDRG2
gene id: 9823:NDRG2
uniprot id: A0A4X1UYJ4
uniprot id: Q001C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

9823:TMSB15A
gene id: 9823:TMSB15A
uniprot id: A0A4X1W3Y1
uniprot id: I3LAC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9823:F9
gene id: 9823:F9
uniprot id: A0A4X1SHD2
uniprot id: F1RQ75
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:PDX1
gene id: 9823:PDX1
uniprot id: A0A287B9A1
uniprot id: A0A4X1TIC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:KEF22 p06
gene id: 9823:KEF22_p06
uniprot id: O79880
uniprot id: Q69G28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9823:ID2
gene id: 9823:ID2
uniprot id: D2EDR1
uniprot id: Q2VIU1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with GATA4 and NKX2-5 (By similarity). Interacts with NR0B2 (By similarity). Interacts with CLOCK and BMAL1 (By similarity). Interacts with IFI204 (By similarity). Interacts with NEDD9/HEF1 (By similarity).
messages: Nucleus
messages: The bHLH domain is essential for its repressor activity towards the CLOCK-BMAL1 heterodimer.
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity).

9823:PAQR3
gene id: 9823:PAQR3
uniprot id: A0A4X1SZW7
uniprot id: F1RVB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:LOC100512911
gene id: 9823:LOC100512911
uniprot id: A0A8D0M7T0
uniprot id: A0A8D1FUI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9823:MAPKAPK3
gene id: 9823:MAPKAPK3
uniprot id: A0A4X1SIW7
uniprot id: B8XSJ7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:LOC100157086
gene id: 9823:LOC100157086
uniprot id: A0A8D1IYV5
uniprot id: F1S7I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:AMZ2
gene id: 9823:AMZ2
uniprot id: A0A287AUC9
uniprot id: A0A4X1SRD4
uniprot id: A0A4X1SRE1
uniprot id: A0A8D1DFZ5
uniprot id: F1RV19
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9823:SGSM1
gene id: 9823:SGSM1
uniprot id: A0A287B2S2
uniprot id: A0A287BIP3
uniprot id: A0A8D0N4E2
uniprot id: A0A8D0WR47
names: Similarity
messages: Belongs to the RUTBC family.

9823:MED30
gene id: 9823:MED30
uniprot id: A0A287B0L2
uniprot id: A0A8D1RE07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9823:LOC100512461
gene id: 9823:LOC100512461
uniprot id: A0A287B4U3
uniprot id: A0A4X1SSF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TMEM200A
gene id: 9823:TMEM200A
uniprot id: A0A8D1A8T7
uniprot id: F1S3M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9823:SPARC
gene id: 9823:SPARC
uniprot id: P20112
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity).
messages: Belongs to the SPARC family.
messages: basement membrane

9823:PDP1
gene id: 9823:PDP1
uniprot id: A0A287A5F9
uniprot id: A0A4X1U8I2
uniprot id: A0A4X1U8P1
uniprot id: A0A8D0SUB9
uniprot id: A0A8D0WRP4
uniprot id: F1RY43
names: Similarity
messages: Belongs to the PP2C family.

9823:ACR
gene id: 9823:ACR
uniprot id: P08001
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
messages: Belongs to the peptidase S1 family.
messages: Heavy chain (catalytic) and a light chain linked by two disulfide bonds. Forms a heterodimer with SERPINA5 (By similarity).
messages: Inhibited by SERPINA5.

9823:CENPM
gene id: 9823:CENPM
uniprot id: A0A4X1W299
uniprot id: C1K0H9
names: Subcellular Location Annotation
messages: Nucleus

9823:LPIN2
gene id: 9823:LPIN2
uniprot id: B6VE05
names: Similarity
messages: Belongs to the lipin family.

9823:SAT1
gene id: 9823:SAT1
uniprot id: Q28999
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Also acts on 1,3-diaminopropane and 1,5-diaminopentane.
messages: Homodimer.
messages: cytosol

9823:OAF
gene id: 9823:OAF
uniprot id: A0A481BCF8
uniprot id: A0A4X1VG34
names: Similarity
messages: Belongs to the OAF family.

9823:ANXA5
gene id: 9823:ANXA5
uniprot id: A0A8D0QF74
uniprot id: F2Z5C1
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9823:PNCK
gene id: 9823:PNCK
uniprot id: D3K5L6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:S100Z
gene id: 9823:S100Z
uniprot id: A0A8D1PP46
names: Similarity
messages: Belongs to the S-100 family.

9823:WDR76
gene id: 9823:WDR76
uniprot id: A0A4X1VBN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9823:YWHAG
gene id: 9823:YWHAG
uniprot id: A0A4X1UM41
uniprot id: F2Z4Z1
names: Similarity
messages: Belongs to the 14-3-3 family.

9823:SFXN5
gene id: 9823:SFXN5
uniprot id: A0A4X1W8A9
uniprot id: F1SLF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9823:SLC39A9
gene id: 9823:SLC39A9
uniprot id: A0A4X1U4B0
uniprot id: A0A8D1F053
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: perinuclear region
messages: trans-Golgi network membrane

9823:METAP1D
gene id: 9823:METAP1D
uniprot id: A0A287ABG5
uniprot id: A0A8D2CF99
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9823:TMEM9
gene id: 9823:TMEM9
uniprot id: A0A287A166
uniprot id: A0A4X1SJH0
names: Similarity
messages: Belongs to the TMEM9 family.

9823:TMEM237
gene id: 9823:TMEM237
uniprot id: A0A4X1V674
uniprot id: A0A8D0PC51
uniprot id: A0A8D1CSS0
uniprot id: A0A8D1N3E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9823:ZDHHC7
gene id: 9823:ZDHHC7
uniprot id: A0A4X1T3L7
uniprot id: A0A4X1T3M2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:LMBR1L
gene id: 9823:LMBR1L
uniprot id: A0A8D0IM54
uniprot id: F1SJ09
names: Similarity
messages: Belongs to the LIMR family.

9823:ATG4B
gene id: 9823:ATG4B
uniprot id: A0A8D1AWD2
uniprot id: D7RA22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9823:SNF8
gene id: 9823:SNF8
uniprot id: A0A4X1UL97
uniprot id: I3L6X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

9823:LOC106510156
gene id: 9823:LOC106510156
uniprot id: A0A8W4F8Z0
names: Similarity
messages: Belongs to the LCE family.

9823:TFEC
gene id: 9823:TFEC
uniprot id: A0A8D1G977
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9823:LOC100625691
gene id: 9823:LOC100625691
uniprot id: A0A8D1Q9F6
uniprot id: A0A8D1VPL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CAPN7
gene id: 9823:CAPN7
uniprot id: A0FKG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Nucleus

9823:CMAH
gene id: 9823:CMAH
uniprot id: A8WAC5
names: Function
names: Similarity
messages: Belongs to the CMP-Neu5Ac hydroxylase family.
messages: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.

9823:NME1
gene id: 9823:NME1
uniprot id: A0A287AS29
uniprot id: A0A4X1V8M9
names: Similarity
messages: Belongs to the NDK family.

9823:S100A2
gene id: 9823:S100A2
uniprot id: A0A4X1W2G6
uniprot id: A0A8D0N355
names: Similarity
messages: Belongs to the S-100 family.

9823:LOC100737844
gene id: 9823:LOC100737844
uniprot id: A0A8D1YWD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SPNS3
gene id: 9823:SPNS3
uniprot id: A0A4X1UMA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9823:PPP3CC
gene id: 9823:PPP3CC
uniprot id: A0A481CE02
uniprot id: A0A4X1VFL0
uniprot id: A0A4X1VGK6
uniprot id: A0A8D0JET5
uniprot id: A0A8D0RCT5
uniprot id: A0A8D1BQN9
uniprot id: A0A8D1NXA8
uniprot id: A0A8D1P616
uniprot id: A0A8W4FFR5
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9823:IFN-DELTA-1
gene id: 9823:IFN-DELTA-1
uniprot id: Q29114
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:PFDN6
gene id: 9823:PFDN6
uniprot id: A0A4X1TGI0
uniprot id: A0A8D0JJ21
uniprot id: F1RZT2
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9823:PTGS2
gene id: 9823:PTGS2
uniprot id: Q8SPR3
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ETF1
gene id: 9823:ETF1
uniprot id: A0A4X1V8F0
uniprot id: A0A8D0HZG3
uniprot id: F2Z505
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

9823:GVIN1
gene id: 9823:GVIN1
uniprot id: A0A8W4F6S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9823:ETV1
gene id: 9823:ETV1
uniprot id: A0A286ZS29
uniprot id: A0A4X1TLB8
uniprot id: A0A8D0HUQ1
uniprot id: A0A8D0RVR3
uniprot id: A0A8D0UQH8
uniprot id: A0A8D1YVE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:AATF
gene id: 9823:AATF
uniprot id: A0A4X1SYZ2
uniprot id: A0A5G2QIB9
names: Similarity
messages: Belongs to the AATF family.

9823:SLC35A3
gene id: 9823:SLC35A3
uniprot id: Q52NI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9823:UBL4A
gene id: 9823:UBL4A
uniprot id: A0A480JSN3
uniprot id: A0A4X1T7Z6
names: Subcellular Location Annotation
messages: cytosol

9823:BAALC
gene id: 9823:BAALC
uniprot id: Q8WNE9
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in the brain.
messages: Interacts with CAMK2A.
messages: May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A.
messages: Membrane raft
messages: Palmitoylation and myristoylation target the protein to the lipid rafts.
messages: Postsynaptic density
messages: synaptosome

9823:ATF7IP
gene id: 9823:ATF7IP
uniprot id: A0A287A8A1
uniprot id: A0A4X1V8L9
uniprot id: A0A4X1V8N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9823:MED7
gene id: 9823:MED7
uniprot id: A0A480SYR1
uniprot id: Q2F7Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

9823:HOXB7
gene id: 9823:HOXB7
uniprot id: A0A8D1CE42
uniprot id: F1RWG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:RSC1A1
gene id: 9823:RSC1A1
uniprot id: Q29106
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Interacts with YRDC.
messages: Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (By similarity).
messages: Nucleus
messages: Renal outer cortex and outer medulla, small intestine and liver.
messages: trans-Golgi network

9823:APOA5
gene id: 9823:APOA5
uniprot id: A0A4X1T0T3
uniprot id: C1KBZ5
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9823:HDAC1
gene id: 9823:HDAC1
uniprot id: A0A4X1VYK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

9823:PIGH
gene id: 9823:PIGH
uniprot id: A0A287A3K3
uniprot id: A0A481AC83
uniprot id: A0A4X1U3F7
uniprot id: A0A8D0P9T4
names: Similarity
messages: Belongs to the PIGH family.

9823:RPS27
gene id: 9823:RPS27
uniprot id: A0A4X1W2B6
uniprot id: A0A8D1WC92
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9823:EEF1AKMT2
gene id: 9823:EEF1AKMT2
uniprot id: A0A4X1VBN4
uniprot id: F1SDP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: Nucleus
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.

9823:IL13
gene id: 9823:IL13
uniprot id: B3GDZ5
uniprot id: Q95J68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-4/IL-13 family.
messages: Cytokine that plays important roles in allergic inflammation and immune response to parasite infection. Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils. Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6. Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (By similarity).
messages: Interacts with IL13RA2.
messages: Secreted

9823:XPA
gene id: 9823:XPA
uniprot id: A0A4X1U7S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9823:B3GAT3
gene id: 9823:B3GAT3
uniprot id: A0A287BQN8
uniprot id: A0A480PGI2
uniprot id: A0A4X1VN90
uniprot id: A0A8D0T908
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:ATP6V1H
gene id: 9823:ATP6V1H
uniprot id: A0A8D1W4Y2
uniprot id: F1RSG6
uniprot id: Q9TVC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with AP2M1 (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.
messages: clathrin-coated vesicle membrane

9823:DGCR14
gene id: 9823:DGCR14
uniprot id: A0A4X1UQD0
uniprot id: F1RK78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9823:ARPC1A
gene id: 9823:ARPC1A
uniprot id: A0A4X1U864
uniprot id: A0A8D0I639
uniprot id: B5APU5
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

9823:RUNDC3B
gene id: 9823:RUNDC3B
uniprot id: A0A287A5J4
uniprot id: A0A4X1T0G1
uniprot id: A0A8D0PPJ7
uniprot id: A0A8D0PPR0
uniprot id: I3LAW8
names: Similarity
names: Subunit
messages: Belongs to the RUNDC3 family.
messages: Interacts with RAP2A.

9823:LOC102165039
gene id: 9823:LOC102165039
uniprot id: A0A4X1TJ62
uniprot id: F1RR01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9823:KCNA10
gene id: 9823:KCNA10
uniprot id: A0A8D0SXT8
names: Subcellular Location Annotation
messages: Membrane

9823:AQP1
gene id: 9823:AQP1
uniprot id: Q6PQZ1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane.
messages: Homotetramer. Component of the ankyrin-1 complex in the erythrocyte, composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1 (By similarity). Interacts with EPHB2; involved in endolymph production in the inner ear (By similarity). Identified in a complex with STOM. Interacts (via the N-terminal) with ANK1 (via ANK 1-5 repeats). Interacts (via the C-terminal) with EPB42 (By similarity).
messages: Pharmacologically inhibited by submillimolar concentrations of mercury.

9823:LOC641352
gene id: 9823:LOC641352
uniprot id: A0A4X1TTB8
uniprot id: Q3T2L1
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:AMHR2
gene id: 9823:AMHR2
uniprot id: A0A480M865
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

9823:VPS4A
gene id: 9823:VPS4A
uniprot id: A0A4X1SFZ5
uniprot id: A0A8D1Z8E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9823:PLAC8
gene id: 9823:PLAC8
uniprot id: A0A8D0M0Q8
names: Similarity
messages: Belongs to the cornifelin family.

9823:ROPN1
gene id: 9823:ROPN1
uniprot id: D3K5J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

9823:PSMD1
gene id: 9823:PSMD1
uniprot id: A0A480M9Z1
uniprot id: A0A4X1THV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9823:ESRRB
gene id: 9823:ESRRB
uniprot id: A0A4X1T7Z7
uniprot id: A0A4X1T800
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9823:VEGFD
gene id: 9823:VEGFD
uniprot id: A0A8D0MKI1
uniprot id: F1SQU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9823:STAT3
gene id: 9823:STAT3
uniprot id: E7CR02
uniprot id: Q19S50
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated.
messages: Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, CNTF, LIF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Tyrosine phosphorylated upon stimulation with EGF. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Phosphorylated on Ser-727 by RPS6KA5 (By similarity). Phosphorylation at Tyr-705 by FER, isoform M2 of PKM (PKM2) or PTK6 leads to an increase of its transcriptional activity (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling (By similarity).
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Detected in lung, heart, oviduct, ovary, uterus and kidney (at protein level). Detected in ovary, oviduct, and at lower levels in uterus and lung.
messages: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1 (By similarity). Interacts with IL23R in presence of IL23 (By similarity). Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2 (By similarity). Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear. Interacts with BMX. Interacts with ZIPK/DAPK3. Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. In prostate cancer cells, interacts with PRKCE and promotes DNA binding activity of STAT3 (By similarity). Interacts with STMN3, antagonizing its microtubule-destabilizing activity (By similarity). Interacts with the 'Lys-129' acetylated form of BIRC5/survivin. Interacts with FER. Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain). Interacts with INPP5F; the interaction is independent of STAT3 Tyr-705 phosphorylation status. Interacts with FGFR4 (By similarity). Interacts with OCAD1 (By similarity). Interacts (unphosphorylated or phosphorylated at Ser-727) with PHB1 (By similarity). Interacts and may form heterodimers with NHLH1 (By similarity). Found in a complex with SLC39A6, SLC39A10 and with the 'Ser-727' phosphorylated form of STAT3 throughout mitosis (By similarity).
messages: Involved in the gp130-mediated signaling pathway.
messages: Nucleus
messages: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation (By similarity). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
messages: Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated.

9823:PANK4
gene id: 9823:PANK4
uniprot id: A0A8D1UGN6
uniprot id: I3LPY8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is strongly promoted by Co(2+), Ni(2+), Mg(2+) and Mn(2+). Activity is inhibited by EDTA.
messages: Belongs to the type II pantothenate kinase family.
messages: Cytoplasm
messages: Homodimer. Interacts with PKM.
messages: In the N-terminal section; belongs to the type II pantothenate kinase family.
messages: Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.

9823:NLE1
gene id: 9823:NLE1
uniprot id: I3LTI2
names: Subcellular Location Annotation
messages: nucleolus

9823:RPRD1B
gene id: 9823:RPRD1B
uniprot id: A0A4X1TKC4
uniprot id: A0A8D1MQ66
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9823:TMEM189
gene id: 9823:TMEM189
uniprot id: A0A4X1UGG4
uniprot id: I3LRW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9823:SLC44A1
gene id: 9823:SLC44A1
uniprot id: A0A4X1VDR5
uniprot id: A0A8D0YAM6
uniprot id: K7GL05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9823:INO80
gene id: 9823:INO80
uniprot id: A0A4X1UTT6
uniprot id: F1SSV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

9823:PHLDA2
gene id: 9823:PHLDA2
uniprot id: A0A4X1U8H0
uniprot id: D3Y268
names: Subcellular Location Annotation
messages: Cytoplasm

9823:TWSG1
gene id: 9823:TWSG1
uniprot id: A0A480DUX8
uniprot id: A0A8D0Y1H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

9823:ACOX1
gene id: 9823:ACOX1
uniprot id: A7J0B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9823:DSG2
gene id: 9823:DSG2
uniprot id: A0A8D1PSM6
uniprot id: A0A8W4FGR5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9823:ACTG1
gene id: 9823:ACTG1
uniprot id: A0A8D0UWY1
uniprot id: I3LVD5
names: Similarity
messages: Belongs to the actin family.

9823:KCNE4
gene id: 9823:KCNE4
uniprot id: A0A286ZPX1
uniprot id: A0A8D0HQH8
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9823:GFOD1
gene id: 9823:GFOD1
uniprot id: A0A287B7W3
uniprot id: A0A8D0NYH8
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9823:NEFL
gene id: 9823:NEFL
uniprot id: A0A8D1NA30
uniprot id: F1RJU4
names: Similarity
messages: Belongs to the intermediate filament family.

9823:ADH4
gene id: 9823:ADH4
uniprot id: A0A0K1TQM8
uniprot id: A0A8D0PZV4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9823:ALG6
gene id: 9823:ALG6
uniprot id: A0A8D0Q184
uniprot id: A0A8D1M5U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:MEF2A
gene id: 9823:MEF2A
uniprot id: A2ICN5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation on Lys-403 activates transcriptional activity. Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity). Hyperacetylation by p300 leads to enhanced cardiac myocyte growth and heart failure (By similarity).
messages: Belongs to the MEF2 family.
messages: Binds DNA as a homo- or heterodimer (By similarity). Dimerizes with MEF2D. Interacts with HDAC7. Interacts with PIAS1; the interaction enhances sumoylation. Interacts with HDAC4, HDAC9 and SLC2A4RG. Interacts (via the N-terminal) with MAPK7; the interaction results in the phosphorylation and transcriptional activity of MEF2A (By similarity).
messages: Constitutive phosphorylation on Ser-408 promotes Lys-403 sumoylation thus preventing acetylation at this site. Dephosphorylation on Ser-408 by PPP3CA upon neuron depolarization promotes a switch from sumoylation to acetylation on residue Lys-403 leading to inhibition of dendrite claw differentiation. Phosphorylation on Thr-312 and Thr-319 are the main sites involved in p38 MAPK signaling and activate transcription. Phosphorylated on these sites by MAPK14/p38alpha and MAPK11/p38beta, but not by MAPK13/p38delta nor by MAPK12/p38gamma. Phosphorylation on Ser-408 by CDK5 induced by neurotoxicity inhibits MEF2A transcriptional activation leading to apoptosis of cortical neurons. Phosphorylation on Thr-312, Thr-319 and Ser-355 can be induced by EGF (By similarity).
messages: Nucleus
messages: Proteolytically cleaved on several sites by caspase 3 and caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to cortical neuron apoptosis and transcriptional inactivation (By similarity).
messages: Sumoylation on Lys-403 is enhanced by PIAS1 and represses transcriptional activity. Phosphorylation on Ser-408 is required for sumoylation. Has no effect on nuclear location nor on DNA binding. Sumoylated with SUMO1 and, to a lesser extent with SUMO2 and SUMO3. PIASx facilitates sumoylation in postsynaptic dendrites in the cerebellar cortex and promotes their morphogenesis (By similarity).
messages: The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity.
messages: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter (By similarity).

9823:TEC
gene id: 9823:TEC
uniprot id: A0A8D1Q628
uniprot id: F1SEA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:PFDN5
gene id: 9823:PFDN5
uniprot id: A0A4X1WBA6
uniprot id: F1SFR1
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9823:PEX10
gene id: 9823:PEX10
uniprot id: A0A4X1W8U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9823:SCGB1C1
gene id: 9823:SCGB1C1
uniprot id: A0A4X1SE94
uniprot id: A0A8D1CY27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9823:TRAPPC2
gene id: 9823:TRAPPC2
uniprot id: F1SRI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Nucleus
messages: Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with ENO1, PITX1, SF1, TRAPPC2L and TRAPPC3.
messages: Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity).
messages: perinuclear region

9823:LOC100623897
gene id: 9823:LOC100623897
uniprot id: A0A4X1TV12
uniprot id: A0A8D1ZB85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SETDB2
gene id: 9823:SETDB2
uniprot id: A0A4X1SK60
uniprot id: A0A8D0VN34
uniprot id: F1RK20
names: Subcellular Location Annotation
messages: Chromosome

9823:MRPL13
gene id: 9823:MRPL13
uniprot id: A0A4X1T5B5
uniprot id: A0A8D0TP66
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9823:MPP3
gene id: 9823:MPP3
uniprot id: A0A4X1TQE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane

9823:SLC35A5
gene id: 9823:SLC35A5
uniprot id: A0A8D0YQ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9823:NUDT2
gene id: 9823:NUDT2
uniprot id: A0A480UP49
uniprot id: P50584
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (PubMed:9147133). Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (By similarity).
messages: Divalent metal ions.
messages: Inhibited by fluoride ions.

9823:MAPKAPK2
gene id: 9823:MAPKAPK2
uniprot id: A0A4X1US57
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:PGF
gene id: 9823:PGF
uniprot id: A0A4X1TBZ8
uniprot id: A0A4X1TCD5
uniprot id: A0A8W4FER5
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9823:XIRP2
gene id: 9823:XIRP2
uniprot id: A0A287AHZ3
uniprot id: A0A8D0S7S9
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9823:RPS20
gene id: 9823:RPS20
uniprot id: A1XQU9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Polyubiquitinated by ZNF598 via 'Lys-63'-linked ubiquitin chains when a ribosome has stalled, initiating the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide. Deubiquitinated by OTUD3 and USP21, antagonizing ZNF598 activity.
messages: Ufmylated by UFL1.

9823:GHR
gene id: 9823:GHR
uniprot id: Q4F787
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Cell membrane
messages: Membrane
messages: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

9823:MPZ
gene id: 9823:MPZ
uniprot id: F1S1B2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myelin P0 protein family.
messages: Cell membrane
messages: Homodimer and homotetramer.
messages: Membrane

9823:LOC102161030
gene id: 9823:LOC102161030
uniprot id: A0A287B7A8
uniprot id: A0A4X1SXM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9823:SOX4
gene id: 9823:SOX4
uniprot id: A0A8D1M1V6
uniprot id: F1RUF9
names: Subcellular Location Annotation
messages: Nucleus

9823:GDF11
gene id: 9823:GDF11
uniprot id: E7ECV9
uniprot id: Q9BG54
names: Similarity
messages: Belongs to the TGF-beta family.

9823:TMED6
gene id: 9823:TMED6
uniprot id: A0A8D0SFL7
uniprot id: F1S389
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:TMEM35A
gene id: 9823:TMEM35A
uniprot id: A0A4X1W631
uniprot id: I3LKJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9823:L3MBTL3
gene id: 9823:L3MBTL3
uniprot id: A0A480KJY4
uniprot id: A0A480QFR5
uniprot id: A0A4X1UR41
uniprot id: A0A4X1USZ3
uniprot id: A0A8D1XMV2
names: Subcellular Location Annotation
messages: Nucleus

9823:FGF1
gene id: 9823:FGF1
uniprot id: A0A4X1STD1
uniprot id: F1RM38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9823:ALDH9A1
gene id: 9823:ALDH9A1
uniprot id: A0A8D0RIX3
uniprot id: F1S232
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9823:FAM109B
gene id: 9823:FAM109B
uniprot id: A0A287BQ05
uniprot id: A0A8D0R2I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9823:SLC10A2
gene id: 9823:SLC10A2
uniprot id: A0A287AWP6
uniprot id: A0A4X1U8Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9823:NKX2-1
gene id: 9823:NKX2-1
uniprot id: A0A287BE97
uniprot id: A0A4X1TCH0
uniprot id: A0A4X1TDB1
names: Subcellular Location Annotation
messages: Nucleus

9823:MRPL10
gene id: 9823:MRPL10
uniprot id: A0A480VPY3
uniprot id: A0A8D0ZEZ5
uniprot id: A0A8D1CRL6
uniprot id: F1RWJ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

9823:ATP5F1
gene id: 9823:ATP5F1
uniprot id: A0A8D0MI69
uniprot id: A0A8D1JEE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9823:TEFM
gene id: 9823:TEFM
uniprot id: A0A8D1PZ95
uniprot id: F1RKW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEFM family.
messages: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
messages: mitochondrion nucleoid

9823:E2F5
gene id: 9823:E2F5
uniprot id: A0A4X1UDJ9
uniprot id: F1RXB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9823:CD14
gene id: 9823:CD14
uniprot id: A7BG66
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane raft
messages: Secreted

9823:TRIM10
gene id: 9823:TRIM10
uniprot id: A0A8D1SJK9
uniprot id: B6ICU9
uniprot id: F1RZ50
uniprot id: O19085
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association of TYK2 and IFNAR1 (By similarity).
messages: Interacts with IFNAR1; this interaction prevents association of IFNAR1 with TYK2.

9823:RASGRP4
gene id: 9823:RASGRP4
uniprot id: A0A4X1T8I5
uniprot id: K7GMW2
names: Similarity
messages: Belongs to the RASGRP family.

9823:GLP2R
gene id: 9823:GLP2R
uniprot id: F8V3Z1
names: Subcellular Location Annotation
messages: Membrane

9823:HSPA6
gene id: 9823:HSPA6
uniprot id: Q04967
names: Domain
names: Function
names: Induction
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: By heat shock.
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.

9823:BARHL1
gene id: 9823:BARHL1
uniprot id: A0A4X1T443
uniprot id: F1S0T9
names: Subcellular Location Annotation
messages: Nucleus

9823:NPY1R
gene id: 9823:NPY1R
uniprot id: A0A4X1TYG4
uniprot id: A0A8D0JHH8
uniprot id: O02835
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for neuropeptide Y and peptide YY.

9823:PAX5
gene id: 9823:PAX5
uniprot id: A0A480E738
names: Subcellular Location Annotation
messages: Nucleus

9823:GBP2
gene id: 9823:GBP2
uniprot id: B2XWS2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9823:HAPLN2
gene id: 9823:HAPLN2
uniprot id: A0A4X1VXX6
uniprot id: F1RP37
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:KIAA0907
gene id: 9823:KIAA0907
uniprot id: A0A480JWI4
uniprot id: A0A4X1VU75
names: Similarity
messages: Belongs to the KHDC4 family.

9823:MYD88
gene id: 9823:MYD88
uniprot id: A2TF48
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
messages: Cytoplasm
messages: Expressed in esophagus, duodenum, jejenum, ileum, ileal Peyer patches, mesenteric lymph node, colon and spleen.
messages: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1. Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct. Interacts with OTUD4 deubiquitinase; the interaction is direct.
messages: Nucleus
messages: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
messages: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.

9823:POU2F2
gene id: 9823:POU2F2
uniprot id: Q29013
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Interacts with NR3C1, AR and PGR. Interacts with POU2AF1; the interaction increases POU2F2 transactivation activity.
messages: Nucleus
messages: Predominantly expressed in B-cells.
messages: Transactivation activity is enhanced by transcriptional coactivator POU2AF1.
messages: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates IL6 expression in B cells with POU2AF1. Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR.

9823:LPIN3
gene id: 9823:LPIN3
uniprot id: B6VE06
names: Similarity
messages: Belongs to the lipin family.

9823:ERCC3
gene id: 9823:ERCC3
uniprot id: A0A8D1HKA8
uniprot id: F1RXZ5
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

9823:CLN8
gene id: 9823:CLN8
uniprot id: A0A287AVL9
uniprot id: A0A8D0WA33
names: Subcellular Location Annotation
messages: Membrane

9823:CCNF
gene id: 9823:CCNF
uniprot id: A0A287AJZ4
uniprot id: A0A8D0QBC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: Nucleus
messages: centriole
messages: perinuclear region

9823:LOC100621476
gene id: 9823:LOC100621476
uniprot id: A0A8D1D5D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9823:POU5F1
gene id: 9823:POU5F1
uniprot id: Q9TSV5
names: Biotechnology
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Cytoplasm
messages: ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.
messages: Interacts with PKM. Interacts with WWP2. Interacts with UBE2I and ZSCAN10. Interacts with PCGF1. Interacts with ESRRB; recruits ESRRB near the POU5F1-SOX2 element in the NANOG proximal promoter; the interaction is DNA independent. Interacts with ZNF322. Interacts with MAPK8 and MAPK9; the interaction allows MAPK8 and MAPK9 to phosphorylate POU5F1 on Ser-355. Interacts (when phosphorylated on Ser-355) with FBXW8. Interacts with FBXW4. Interacts with SOX2 and SOX15; binds synergistically with either SOX2 or SOX15 to DNA (By similarity). Interacts with DDX56 (By similarity).
messages: Nucleus
messages: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
messages: Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: The POU-specific domain mediates interaction with PKM.
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
messages: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation.

9823:CPSF3
gene id: 9823:CPSF3
uniprot id: A0A4X1UGM3
uniprot id: A0A4X1UH53
uniprot id: A0A8D0YNE9
uniprot id: A0A8D1EW24
names: Subcellular Location Annotation
messages: Nucleus

9823:CD3G
gene id: 9823:CD3G
uniprot id: Q5PXD3
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.
messages: Cell membrane
messages: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
messages: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
messages: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. Phosphorylated also by PKC; leading to the TCR complex down-regulation.
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.

9823:SLA-DQB1
gene id: 9823:SLA-DQB1
uniprot id: P15982
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Membrane

9823:ABHD2
gene id: 9823:ABHD2
uniprot id: A0A4X1U5A9
uniprot id: A0A8D1IAG6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9823:MMP9
gene id: 9823:MMP9
uniprot id: Q2VI03
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

9823:FATE1
gene id: 9823:FATE1
uniprot id: Q95LB4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with BIK and RNF183. Interacts with IMMT/MIC60and EMD.
messages: Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling.
messages: Mitochondrion
messages: Mitochondrion outer membrane

9823:YIF1A
gene id: 9823:YIF1A
uniprot id: A0A4X1TTT0
uniprot id: A0A4X1TTW2
uniprot id: A0A8D1V5Y1
uniprot id: A0A8D1Y229
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:LOC100518060
gene id: 9823:LOC100518060
uniprot id: A0A4X1SXR3
uniprot id: A0A8W4FFR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:IFNAR1
gene id: 9823:IFNAR1
uniprot id: Q764M8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Heterodimer with IFNAR2; forming the receptor for type I interferon. Interacts with TYK2. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-482. Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Interacts with SHMT2; this promotes interaction with ABRAXAS2 and the BRISC complex. Interacts with TRIM10; this interaction prevents association between IFNAR1 and TYK2.
messages: Late endosome
messages: Lysosome
messages: Palmitoylation at Cys-464 is required for the activation of STAT1 and STAT2.
messages: Phosphorylated on tyrosine residues in response to interferon-binding: phosphorylation by TYK2 tyrosine kinase creates docking sites for STAT proteins. Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination.
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
messages: Ubiquitinated, leading to its internalization and degradation. Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation. The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex.

9823:LOC100525034
gene id: 9823:LOC100525034
uniprot id: A0A4X1UYT5
uniprot id: A0A8D1KRY3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC102162202
gene id: 9823:LOC102162202
uniprot id: A0A287BID4
uniprot id: A0A8D0MDG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:SPOPL
gene id: 9823:SPOPL
uniprot id: A0A287AS40
uniprot id: A0A4X1T001
uniprot id: A0A8D0P2Y3
uniprot id: A0A8D1CSW9
names: Similarity
messages: Belongs to the Tdpoz family.

9823:ADAM30
gene id: 9823:ADAM30
uniprot id: A0A4X1TA74
uniprot id: A0A8D1Z248
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CAPZA1
gene id: 9823:CAPZA1
uniprot id: A0A4X1T8I3
uniprot id: A0PFK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (PubMed:36071160, PubMed:25814576, PubMed:29420470, PubMed:33734450).
messages: Heterodimer of an alpha and a beta subunit (PubMed:25814576, PubMed:29420470, PubMed:33734450, PubMed:36071160). Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3 (PubMed:33734450, PubMed:36071160). The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6 (PubMed:33734450). The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin (PubMed:33734450, PubMed:36071160). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. Interacts with S100B. Interacts with SH3BP1; recruits CAPZA1 to forming cell junctions. Interacts with CD2AP. Directly interacts with CRACD; this interaction decreases binding to actin (By similarity).
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

9823:NDUFA7
gene id: 9823:NDUFA7
uniprot id: A0A4X1VLA2
uniprot id: A0A8W4F7N8
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

9823:STX16
gene id: 9823:STX16
uniprot id: A0A4X1UST5
uniprot id: A0A4X1UTY6
uniprot id: A0A8D0UWQ6
uniprot id: A0A8D1E861
uniprot id: A0A8D2BLI7
uniprot id: A5GFS9
uniprot id: A5GFT0
uniprot id: A5GFT1
uniprot id: A5GFT2
names: Similarity
messages: Belongs to the syntaxin family.

9823:FAM208A
gene id: 9823:FAM208A
uniprot id: A0A287B2V7
uniprot id: A0A480JUE6
uniprot id: A0A8D0WZE9
names: Similarity
messages: Belongs to the TASOR family.

9823:NOS2
gene id: 9823:NOS2
uniprot id: B8XH66
uniprot id: F1RJ31
uniprot id: P79290
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Detected in both stimulated and unstimulated immune cells and macrophages with little or no up-regulation following cellular stimulation with lipopolysaccharides (LPS) or concanavalin A (ConA).
messages: Homodimer. Interacts with NHERF1. Interacts with GAPDH; induced by oxidatively-modified low-densitity lipoprotein (LDL(ox)). Interacts with S100A8 and S100A9 to form the iNOS-S100A8/9 transnitrosylase complex. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with ELOC and CUL5 in the presence of SPSB1 or SPSB2 or SPSB4. Forms a complex with ASL, ASS1 and HSP90AA1; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway.
messages: Little by LPS or ConA in spleen cells.
messages: Not stimulated by calcium/calmodulin.
messages: Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8.
messages: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
messages: cytosol

9823:DNAJA4
gene id: 9823:DNAJA4
uniprot id: Q864B5
names: Subcellular Location Annotation
messages: Membrane

9823:CYP19A3
gene id: 9823:CYP19A3
uniprot id: P79304
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
messages: Membrane
messages: Ovary.

9823:PPP2R5B
gene id: 9823:PPP2R5B
uniprot id: A0A4X1V1A1
uniprot id: F1RQR5
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9823:MPP2
gene id: 9823:MPP2
uniprot id: A0A8D0XWB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane

9823:LOC100524613
gene id: 9823:LOC100524613
uniprot id: A0A4X1V0F2
names: Similarity
messages: Belongs to the peptidase M16 family.

9823:IL1A
gene id: 9823:IL1A
uniprot id: P18430
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated within its nuclear localization sequence, which impacts subcellular localization.
messages: Belongs to the IL-1 family.
messages: Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
messages: Cytoplasm
messages: Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane.
messages: Nucleus
messages: Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.
messages: Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules.
messages: Secreted
messages: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

9823:SUMO1
gene id: 9823:SUMO1
uniprot id: A7WLH8
uniprot id: B0M1N0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cell membrane
messages: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
messages: Covalently attached to KCNB1; UBE2I increases cross-linking with KCNB1 and PIAS1 decreases cross-links with KCNB1 (By similarity). Interacts with SAE2, RANBP2, PIAS1 and PIAS2 (By similarity). Interacts with PRKN (By similarity). Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG (By similarity). Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52 (By similarity). Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25 (By similarity). Interacts with SIMC1, CASP8AP2, RNF111 and SOBP (via SIM domains) (By similarity). Interacts with BHLHE40/DEC1 (By similarity). Interacts with RWDD3 (By similarity). Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3 (By similarity). Interacts with MTA1 (By similarity). Interacts with SENP2 (By similarity). Interacts with HINT1 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Nucleus membrane
messages: Nucleus speckle
messages: PML body
messages: Polymeric SUMO1 chains undergo polyubiquitination by RNF4.
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3.

9823:SGPL1
gene id: 9823:SGPL1
uniprot id: A0A287AX55
uniprot id: A0A8D0TKS3
uniprot id: A0A8D0Y1S1
uniprot id: K9IVV1
names: Similarity
messages: Belongs to the group II decarboxylase family.

9823:COLGALT1
gene id: 9823:COLGALT1
uniprot id: A0A287AXP9
uniprot id: A0A4X1UDT4
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9823:UPF3B
gene id: 9823:UPF3B
uniprot id: A0A480VMS7
uniprot id: A0A4X1W0E7
uniprot id: A0A4X1W5C4
uniprot id: A0A8D0U224
names: Similarity
messages: Belongs to the RENT3 family.

9823:CTSF
gene id: 9823:CTSF
uniprot id: A0A480TE38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9823:LOC100157763
gene id: 9823:LOC100157763
uniprot id: A0A287B0L6
uniprot id: A0A8D1V4W1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:MAOA
gene id: 9823:MAOA
uniprot id: Q6Q2J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).

9823:INIP
gene id: 9823:INIP
uniprot id: A0A4X1V4M4
uniprot id: A0A8D1BIX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9823:ADRB1
gene id: 9823:ADRB1
uniprot id: Q28998
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).
messages: Cell membrane
messages: Early endosome
messages: Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
messages: Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3 and DLG4 (By similarity).
messages: The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.

9823:TRIM9
gene id: 9823:TRIM9
uniprot id: A0A4X1SDQ9
uniprot id: A0A4X1SDS7
uniprot id: A0A4X1SDU8
uniprot id: A0A8D0PV30
uniprot id: A0A8W4F9F1
uniprot id: F1SFF7
names: Subcellular Location Annotation
messages: cytoskeleton

9823:CHN2
gene id: 9823:CHN2
uniprot id: A0A287BPP5
uniprot id: A0A4X1TK96
names: Function
messages: GTPase-activating protein for p21-rac.

9823:LOC100738896
gene id: 9823:LOC100738896
uniprot id: A0A0G3VNL1
uniprot id: A0A8D0TRZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:CRISP3
gene id: 9823:CRISP3
uniprot id: A0A8D1PUK4
uniprot id: I3LVL5
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:HMBS
gene id: 9823:HMBS
uniprot id: A0A8D1UN18
uniprot id: A0SNU8
names: Similarity
messages: Belongs to the HMBS family.

9823:CLK3
gene id: 9823:CLK3
uniprot id: A0A4X1TKM3
uniprot id: F1SIE6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:CBLC
gene id: 9823:CBLC
uniprot id: A0A480QW23
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9823:VSX1
gene id: 9823:VSX1
uniprot id: A0A4X1V1M7
uniprot id: I3LGC8
names: Subcellular Location Annotation
messages: Nucleus

9823:FAM131A
gene id: 9823:FAM131A
uniprot id: A0A4X1UIP4
uniprot id: A0A4X1UNU6
uniprot id: A0A8D0S1U3
uniprot id: A0A8W4F6R8
names: Similarity
messages: Belongs to the FAM131 family.

9823:BARX2
gene id: 9823:BARX2
uniprot id: A0A287AJ07
names: Subcellular Location Annotation
messages: Nucleus

9823:TOR1A
gene id: 9823:TOR1A
uniprot id: A0A4X1THU4
uniprot id: A7YX23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9823:PHKA2
gene id: 9823:PHKA2
uniprot id: A0A286ZQP9
uniprot id: A0A480KNT6
uniprot id: A0A8D0PXM0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9823:EPHA4
gene id: 9823:EPHA4
uniprot id: B5M6R3
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Membrane

9823:AMACR
gene id: 9823:AMACR
uniprot id: A0A4X1TFH2
uniprot id: A0A8D1NIZ7
names: Similarity
messages: Belongs to the CoA-transferase III family.

9823:DDB2
gene id: 9823:DDB2
uniprot id: A0A8D0NIL4
uniprot id: A0A8D0U1T9
uniprot id: A0A8D0VU03
uniprot id: F1SIC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

9823:HARS
gene id: 9823:HARS
uniprot id: A0A8D1PIL7
uniprot id: A0A8D2AAA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

9823:SLC35A1
gene id: 9823:SLC35A1
uniprot id: F1S0G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9823:REC8
gene id: 9823:REC8
uniprot id: F1SGN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9823:BORCS7
gene id: 9823:BORCS7
uniprot id: A0A4X1TTC6
uniprot id: A0A8D0IUZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Lysosome membrane
messages: Membrane

9823:DESI1
gene id: 9823:DESI1
uniprot id: A0A480K058
uniprot id: A0A4X1VXE9
uniprot id: A0A4X1W202
names: Similarity
messages: Belongs to the DeSI family.

9823:PIM2
gene id: 9823:PIM2
uniprot id: A0A4X1VJM5
uniprot id: I3L8X4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9823:IL33
gene id: 9823:IL33
uniprot id: A0A4X1W934
uniprot id: A0A8D1K190
uniprot id: A0A8D1XME2
uniprot id: M5B263
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Nucleus
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9823:INSL6
gene id: 9823:INSL6
uniprot id: A0A4X1W963
uniprot id: F1SK47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9823:ZNF75D
gene id: 9823:ZNF75D
uniprot id: A0A8D0RJH9
uniprot id: K7GN93
uniprot id: K7GNG7
names: Subcellular Location Annotation
messages: Nucleus

9823:AZU1
gene id: 9823:AZU1
uniprot id: P80015
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Elastase subfamily.
messages: Cytoplasmic granule membrane
messages: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin.

9823:NDUFA2
gene id: 9823:NDUFA2
uniprot id: A0A8D1FN21
uniprot id: F1RGE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:SLC22A3
gene id: 9823:SLC22A3
uniprot id: A0A4X1VVG5
uniprot id: F1SB80
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9823:ANXA1
gene id: 9823:ANXA1
uniprot id: P19619
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Detected in lung and spleen (at protein level).
messages: Early endosome
messages: Endosome
messages: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
messages: Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation. Homodimers linked by transglutamylation are observed in placenta, but not in other tissues. Interacts with S100A11. Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (By similarity). Interacts with DYSF (By similarity). Interacts with EGFR (By similarity).
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: Phosphorylated by EGFR (PubMed:3020049). Phosphorylated by protein kinase C and TRPM7 (By similarity). Phosphorylated in response to EGF treatment (PubMed:3020049).
messages: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (PubMed:12595246). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:8885232). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
messages: Proteolytically cleaved by cathepsin CTSG to release the active N-terminal peptide Ac2-26.
messages: Secreted
messages: Sumoylated.
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)-dependent binding to phospholipid membranes and can promote membrane aggregation in vitro. Was initially identified as inhibitor of phospholipase A2 activity (in vitro). Inhibition of phospholipase activity is mediated via its phospholipid binding activity that limits the access of phospholipase to its substrates.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9823:ELL2
gene id: 9823:ELL2
uniprot id: A0A480JTG5
uniprot id: A0A8D0NBL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9823:CBR2
gene id: 9823:CBR2
uniprot id: Q29529
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Allosteric enzyme exhibiting negative cooperativity. Activated 2-5 fold by fatty acids.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: By glucocorticoids.
messages: Homotetramer.
messages: Lung (ciliated cells, non-ciliated bronchiolar cells and type-II alveolar pneumocytes). Low expression in all extrapulmonary tissues, including adipose tissue.
messages: May function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism.
messages: Mitochondrion matrix
messages: Uses both NADP and NAD as substrates. Has a strong preference for NADP.

9823:LOC100620421
gene id: 9823:LOC100620421
uniprot id: A0A4X1TZI2
uniprot id: A0A8D1I1G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PPIE
gene id: 9823:PPIE
uniprot id: A0A286ZJY9
uniprot id: A0A481BD13
uniprot id: A0A8W4FM44
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

9823:CCNL1
gene id: 9823:CCNL1
uniprot id: A0A4X1SJ67
uniprot id: I3LG02
names: Similarity
messages: Belongs to the cyclin family.

9823:GNA11
gene id: 9823:GNA11
uniprot id: Q2XSV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22. Interacts with NTSR1.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNAQ, required for heart development (By similarity).

9823:LIN7B
gene id: 9823:LIN7B
uniprot id: A0A480TPF2
uniprot id: A0A4X1VU10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9823:CORO2B
gene id: 9823:CORO2B
uniprot id: A0A286ZS32
uniprot id: A0A4X1T6D1
uniprot id: A0A4X1T703
uniprot id: A0A4X1T825
uniprot id: A0A8D0JXS7
names: Similarity
messages: Belongs to the WD repeat coronin family.

9823:LOC100737921
gene id: 9823:LOC100737921
uniprot id: A0A5G2QUZ5
uniprot id: A0A8D1HPS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SLC22A7
gene id: 9823:SLC22A7
uniprot id: Q1RPP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane
messages: Functions as a Na(+)-independent bidirectional multispecific transporter. Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively. Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides and nucleotides, with cGMP, 2'deoxyguanosine and GMP being the preferred substrates. Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways. Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood. Involved in renal secretion and possible reabsorption of creatinine. Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion. Also transports alpha-ketoglutarate and urate. Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified.

9823:LOC100525476
gene id: 9823:LOC100525476
uniprot id: A0A5G2QVW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:HNRNPC
gene id: 9823:HNRNPC
uniprot id: A0A287AJY0
uniprot id: A0A8D0QDA8
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9823:CLCA1
gene id: 9823:CLCA1
uniprot id: Q9TUB5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CLCR family.
messages: Expressed in ileum, trachea, and the major salivary glands. In ileum, expressed to the crypt and villus epithelia, whereas in trachea expressed in both surface epithelium and submucosal glands.
messages: Glycosylated.
messages: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. Induces a cAMP-dependent chloride conductance possibly through effects on CFTR in colon carcinoma cells.
messages: The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.
messages: The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
messages: extracellular space

9823:PTPN4
gene id: 9823:PTPN4
uniprot id: A0A8D0HUI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9823:ESR2
gene id: 9823:ESR2
uniprot id: Q9XSW2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with UBE1C and AKAP13. Interacts with DNTTIP2. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with DNAAF4. Interacts with PRMT2. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts with RBM39, in the presence of estradiol (E2).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
messages: Nucleus
messages: Phosphorylation at Ser-84 and Ser-102 recruits NCOA1.

9823:POLR2M
gene id: 9823:POLR2M
uniprot id: A0A8D0RNR0
uniprot id: A0A8D0RRL3
uniprot id: A0A8D0WX14
uniprot id: A0A8D1GTS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

9823:CCNA1
gene id: 9823:CCNA1
uniprot id: F1RSR0
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9823:TSR3
gene id: 9823:TSR3
uniprot id: A0A287B492
uniprot id: A0A4X1SLV3
uniprot id: F1RFZ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:TPM1
gene id: 9823:TPM1
uniprot id: A0A286ZRE1
uniprot id: A0A287BHM1
uniprot id: A0A8D1NL12
uniprot id: A0A8D1NRS3
uniprot id: A0A8D1S743
uniprot id: A0A8D1XMF9
uniprot id: A0A8D1XNS6
uniprot id: A0A8D1XSE1
uniprot id: A0A8W4FES9
uniprot id: P42639
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
messages: Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain. Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG. Interacts (via N-terminus) with LMOD2 (via N-terminus) and TMOD1 (via N-terminus).
messages: Induced by hypoxia. This induction is reversed by exposure to normal levels of oxygen.
messages: Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

9823:ZER1
gene id: 9823:ZER1
uniprot id: A0A480S9H3
uniprot id: A0A4X1TQE5
uniprot id: F1RR66
names: Similarity
messages: Belongs to the zyg-11 family.

9823:ZC3H12D
gene id: 9823:ZC3H12D
uniprot id: F1S7S2
names: Similarity
messages: Belongs to the ZC3H12 family.

9823:PSMG2
gene id: 9823:PSMG2
uniprot id: A0A286ZXX4
uniprot id: A0A4X1VNT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

9823:HCAR1
gene id: 9823:HCAR1
uniprot id: A0A8D1JHD0
uniprot id: B9UM27
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:LOC100515857
gene id: 9823:LOC100515857
uniprot id: A0A4X1T5L8
uniprot id: A0A8D0IAQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:ASTE1
gene id: 9823:ASTE1
uniprot id: A0A8D1UPU9
uniprot id: A0A8D2BC90
names: Similarity
messages: Belongs to the asteroid family.

9823:B4GALT5
gene id: 9823:B4GALT5
uniprot id: A0A1S6M251
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with porcine reproductive and respiratory syndrome virus GP5.
messages: (Microbial infection) May play a role in the glycosylation of porcine reproductive and respiratory syndrome virus GP5 protein and may be involved in the regulation of viral proliferation.
messages: (Microbial infection) Up-regulated in response to porcine reproductive and respiratory syndrome viral infection.
messages: Belongs to the glycosyltransferase 7 family.
messages: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (By similarity). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity).
messages: Golgi apparatus
messages: Golgi stack membrane

9823:DUS3L
gene id: 9823:DUS3L
uniprot id: A0A4X1VQ95
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

9823:HSD17B4
gene id: 9823:HSD17B4
uniprot id: Q28956
names: Subcellular Location Annotation
messages: Peroxisome

9823:HMGA1
gene id: 9823:HMGA1
uniprot id: A0A4X1T5Y2
uniprot id: B6CVL5
uniprot id: D5KJI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9823:MRPL46
gene id: 9823:MRPL46
uniprot id: A0A8D0N663
uniprot id: F1SRT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

9823:MTRF1
gene id: 9823:MTRF1
uniprot id: F1RJ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9823:CAP1
gene id: 9823:CAP1
uniprot id: A0A8D0ZZA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9823:ABCG4
gene id: 9823:ABCG4
uniprot id: A0A8D1JCD7
uniprot id: F1SAH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9823:LOC100627167
gene id: 9823:LOC100627167
uniprot id: A0A287A242
uniprot id: A0A8D1XB16
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ZDHHC3
gene id: 9823:ZDHHC3
uniprot id: A0A287ABA0
uniprot id: A0A480XDH8
uniprot id: A0A8D1NCW3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:SLC17A7
gene id: 9823:SLC17A7
uniprot id: A0A8D1TY40
uniprot id: F1RHZ7
names: Subcellular Location Annotation
messages: Membrane

9823:PPCS
gene id: 9823:PPCS
uniprot id: A0A4X1W858
uniprot id: F1SF93
names: Similarity
messages: Belongs to the PPC synthetase family.

9823:P2RX3
gene id: 9823:P2RX3
uniprot id: A0A8D0NC53
uniprot id: I3L7H5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9823:MYOZ1
gene id: 9823:MYOZ1
uniprot id: Q4PS85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myozenin family.
messages: Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT (By similarity).
messages: Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity).
messages: Nucleus
messages: pseudopodium

9823:SLC24A5
gene id: 9823:SLC24A5
uniprot id: A0A4X1SFS1
uniprot id: A0A8D1EZS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9823:LOC100623293
gene id: 9823:LOC100623293
uniprot id: A0A8W4FEU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RPS6KA6
gene id: 9823:RPS6KA6
uniprot id: A0A480L5M3
uniprot id: A0A4X1W4I4
uniprot id: A0A8D1G9J3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9823:NSUN3
gene id: 9823:NSUN3
uniprot id: A0A8D1X534
uniprot id: I3LUW7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9823:RAMP3
gene id: 9823:RAMP3
uniprot id: Q7YS88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAMP family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP3. Interacts with GPER1.
messages: Membrane
messages: Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity).

9823:SKA2
gene id: 9823:SKA2
uniprot id: A0A8D0YRY2
uniprot id: F1S259
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

9823:ELK1
gene id: 9823:ELK1
uniprot id: A0A4X1T8E2
uniprot id: K7GQA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:LRRC8D
gene id: 9823:LRRC8D
uniprot id: A0A286ZWM5
uniprot id: A0A4X1U3K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9823:SEC24C
gene id: 9823:SEC24C
uniprot id: A0A286ZQ28
uniprot id: A0A8D1MF20
uniprot id: A0A8D1MFU5
uniprot id: F1SU53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9823:CILP2
gene id: 9823:CILP2
uniprot id: A0A480DH83
uniprot id: A0A4X1U4H9
names: Subcellular Location Annotation
messages: extracellular matrix

9823:MMS19
gene id: 9823:MMS19
uniprot id: A0A480I431
uniprot id: A0A4X1UB84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9823:CTPS1
gene id: 9823:CTPS1
uniprot id: A0A287B3Y5
uniprot id: A0A4X1W5M1
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9823:FXR2
gene id: 9823:FXR2
uniprot id: A0A8D1VVY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cytoplasmic ribonucleoprotein granule
messages: Postsynapse
messages: Synapse

9823:PTGES
gene id: 9823:PTGES
uniprot id: A0A8D2CI57
uniprot id: Q2TJZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9823:F3
gene id: 9823:F3
uniprot id: Q6RCS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

9823:AKR1C1
gene id: 9823:AKR1C1
uniprot id: A0A480SLU2
uniprot id: A0A8D1P9W3
uniprot id: A0A8D1ZRQ7
uniprot id: Q1KLB2
uniprot id: Q1KLB4
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9823:OTC
gene id: 9823:OTC
uniprot id: A0A480E1W6
uniprot id: A0A4X1U355
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9823:OAZ1
gene id: 9823:OAZ1
uniprot id: B2CR15
names: Similarity
messages: Belongs to the ODC antizyme family.

9823:BANF2
gene id: 9823:BANF2
uniprot id: A0A4X1UV79
uniprot id: A0A8D0YNC6
names: Subcellular Location Annotation
messages: Nucleus

9823:PANX1
gene id: 9823:PANX1
uniprot id: A0A287B8K3
uniprot id: A0A8D1CGF9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9823:KATNAL1
gene id: 9823:KATNAL1
uniprot id: A0A8D1W5P6
uniprot id: F1RST8
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9823:PAIP2
gene id: 9823:PAIP2
uniprot id: A0A4X1VBZ4
uniprot id: A0A8D1DVX9
names: Similarity
messages: Belongs to the PAIP2 family.

9823:MED28
gene id: 9823:MED28
uniprot id: A0A480PTL8
uniprot id: A0A4X1VBW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9823:MYOZ2
gene id: 9823:MYOZ2
uniprot id: A0A8D0LT33
uniprot id: Q1AG08
names: Similarity
messages: Belongs to the myozenin family.

9823:INTS8
gene id: 9823:INTS8
uniprot id: A0A8D1XXY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

9823:AMPD1
gene id: 9823:AMPD1
uniprot id: A0A287ASX9
uniprot id: A0A8D0ICX2
uniprot id: A6NA29
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9823:SERPINB2
gene id: 9823:SERPINB2
uniprot id: A0A4X1TSN7
uniprot id: F1SMW7
names: Similarity
messages: Belongs to the serpin family.

9823:HCFC2
gene id: 9823:HCFC2
uniprot id: A0A4X1T6P9
uniprot id: F1SRK9
names: Subcellular Location Annotation
messages: Nucleus

9823:DUSP27
gene id: 9823:DUSP27
uniprot id: A0A5K1V146
uniprot id: A0A8D1QFF7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9823:GABRR2
gene id: 9823:GABRR2
uniprot id: A0A8D0NE06
uniprot id: I3LKA9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:SSU72
gene id: 9823:SSU72
uniprot id: A0A4X1W394
uniprot id: F1RJC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

9823:MANEA
gene id: 9823:MANEA
uniprot id: A0A287B4B5
uniprot id: A0A4X1VHF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:ZP4
gene id: 9823:ZP4
uniprot id: Q07287
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
messages: Disulfide bonds are formed between the cysteines of three consecutive regions: Cys-368 and Cys-389, Cys-442 and Cys-447, Cys-455 and Cys-459.
messages: Expressed in oocytes.
messages: N-glycosylated; contains bi-, tri- and tetra-antennary glycans with N-acetyllactosamine repeats.
messages: O-glycosylated; contains sulfate-substituted glycans.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9823:RTN1
gene id: 9823:RTN1
uniprot id: A0A4X1WCX0
uniprot id: I3LBH0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:GABRA2
gene id: 9823:GABRA2
uniprot id: A0A4X1ULV0
uniprot id: A0A8D0W0Z4
uniprot id: A0A8D1B5M6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9823:AVPR1A
gene id: 9823:AVPR1A
uniprot id: A0A286ZX01
uniprot id: A0A4X1W2U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9823:STX17
gene id: 9823:STX17
uniprot id: A0A4X1VIC7
uniprot id: A0A8D0N3S1
names: Similarity
messages: Belongs to the syntaxin family.

9823:MED31
gene id: 9823:MED31
uniprot id: A0A4X1UL35
uniprot id: A0A8D0RJL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9823:CMTM7
gene id: 9823:CMTM7
uniprot id: A0A8D1AA82
names: Subcellular Location Annotation
messages: Membrane

9823:CACNA1D
gene id: 9823:CACNA1D
uniprot id: A0A480Y640
uniprot id: A0A4X1VL02
uniprot id: A0A4X1VLJ6
uniprot id: A0A4X1VMJ6
uniprot id: A0A4X1VNR9
uniprot id: A0A4X1VNS7
uniprot id: A0A4X1VNT1
uniprot id: A0A5G2QZ70
uniprot id: A0A8D1QJG4
uniprot id: A0A8D1QPZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9823:POLR3H
gene id: 9823:POLR3H
uniprot id: A0A8D0QYN8
uniprot id: F1SRD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9823:FTSJ1
gene id: 9823:FTSJ1
uniprot id: D6BK24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

9823:LOC102161660
gene id: 9823:LOC102161660
uniprot id: A0A8D1FKD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SSTR1
gene id: 9823:SSTR1
uniprot id: A0A4X1TBQ1
uniprot id: A0A8D0ML55
uniprot id: A0A8D1U7Z5
uniprot id: Q866U3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:EMC4
gene id: 9823:EMC4
uniprot id: A0A286ZIA2
uniprot id: A0A8D1N2I3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:C14H12orf49
gene id: 9823:C14H12orf49
uniprot id: A0A480VC18
uniprot id: A0A4X1TRP6
uniprot id: A0A4X1TRQ7
uniprot id: A0A8D1DJX6
uniprot id: A0A8D1DKP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

9823:ACTL6B
gene id: 9823:ACTL6B
uniprot id: A0A4X1U9V0
names: Similarity
messages: Belongs to the actin family.

9823:PRM1
gene id: 9823:PRM1
uniprot id: P04101
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protamine P1 family.
messages: Chromosome
messages: Cross-linked by interchain disulfide bonds around the DNA-helix.
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Testis.

9823:RNF141
gene id: 9823:RNF141
uniprot id: A0A287AJU8
uniprot id: A0A8D1HHB5
names: Function
messages: May be involved in spermatogenesis.

9823:CPNE3
gene id: 9823:CPNE3
uniprot id: A0A4X1UBQ4
uniprot id: A0A8D0JNV1
names: Similarity
messages: Belongs to the copine family.

9823:FOXN2
gene id: 9823:FOXN2
uniprot id: A0A4X1SF11
uniprot id: I3LTD2
names: Subcellular Location Annotation
messages: Nucleus

9823:SLC25A46
gene id: 9823:SLC25A46
uniprot id: M3VK44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:IGBP1
gene id: 9823:IGBP1
uniprot id: A0A4X1VXZ5
uniprot id: K7GQ35
names: Similarity
messages: Belongs to the IGBP1/TAP42 family.

9823:ICAM2
gene id: 9823:ICAM2
uniprot id: A0A4X1SYT5
uniprot id: Q6VY03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9823:ITGB2
gene id: 9823:ITGB2
uniprot id: P53714
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin beta chain family.
messages: Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.
messages: Cell membrane
messages: Heterodimer of an alpha and a beta subunit. The ITGB2 beta subunit associates with the ITGAL, ITGAM, ITGAX or ITGAD alpha subunits. Found in a complex with CD177 and ITGAM/CD11b. Interacts with FGR. Interacts with COPS5 and RANBP9. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23). Interacts with THBD.
messages: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
messages: Membrane raft
messages: The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.

9823:CD36
gene id: 9823:CD36
uniprot id: A0A4X1SIV0
uniprot id: Q3HUX1
names: Similarity
messages: Belongs to the CD36 family.

9823:FZD6
gene id: 9823:FZD6
uniprot id: A0A076V355
uniprot id: A0A8D1Z8Q4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:INA
gene id: 9823:INA
uniprot id: A0A4X1TQZ8
uniprot id: F1S847
names: Similarity
messages: Belongs to the intermediate filament family.

9823:UCHL1
gene id: 9823:UCHL1
uniprot id: A0A480NR20
uniprot id: Q6SEG5
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C12 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.
messages: Monomer. Homodimer. Interacts with COPS5 and SNCA (By similarity).
messages: O-glycosylated.
messages: The homodimer may have ATP-independent ubiquitin ligase activity. However, in another study, UCHL1 was shown to lack ubiquitin ligase activity.
messages: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity).

9823:ATG12
gene id: 9823:ATG12
uniprot id: A0A8D1TFS9
uniprot id: D7RA34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9823:PSMA2
gene id: 9823:PSMA2
uniprot id: A0A8D0RKI8
uniprot id: I3LAB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9823:C6H1orf123
gene id: 9823:C6H1orf123
uniprot id: A0A4X1WAW6
uniprot id: F1S765
names: Similarity
messages: Belongs to the UPF0587 family.

9823:SLC5A10
gene id: 9823:SLC5A10
uniprot id: Q5FY69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2 (By similarity). Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney (By similarity).

9823:DBNL
gene id: 9823:DBNL
uniprot id: A0A4X1U9F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABP1 family.
messages: Early endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

9823:CEP19
gene id: 9823:CEP19
uniprot id: A0A8D0JA53
uniprot id: I3LFS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9823:LOC100515945
gene id: 9823:LOC100515945
uniprot id: A0A4X1SS04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:HSD17B1
gene id: 9823:HSD17B1
uniprot id: A0A4X1TVP1
uniprot id: B2X0A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Favors the reduction of estrogens and androgens. Uses preferentially NADH.

9823:CHURC1
gene id: 9823:CHURC1
uniprot id: A0A4X1UDW4
uniprot id: A0A8D1F017
names: Similarity
messages: Belongs to the Churchill family.

9823:NR1H4
gene id: 9823:NR1H4
uniprot id: A0A8D0VZF5
uniprot id: F1SRH0
uniprot id: V5M0Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9823:RBBP7
gene id: 9823:RBBP7
uniprot id: A0A4X1UYH3
uniprot id: A0A4X1UYR9
uniprot id: A0A5G2RBI2
names: Subcellular Location Annotation
messages: Nucleus

9823:HMGN3
gene id: 9823:HMGN3
uniprot id: A0A287AAB5
uniprot id: F1RQK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9823:CLDN17
gene id: 9823:CLDN17
uniprot id: C3VMW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability.
messages: Interacts with OCLN.
messages: tight junction

9823:CD28
gene id: 9823:CD28
uniprot id: A0A8D0J3N4
uniprot id: I3LKR6
names: Subcellular Location Annotation
messages: Membrane

9823:GPR39
gene id: 9823:GPR39
uniprot id: B2ZHY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).

9823:BANF1
gene id: 9823:BANF1
uniprot id: A0A4X1UGA0
uniprot id: F1RU33
names: Subcellular Location Annotation
messages: Nucleus

9823:KIF4A
gene id: 9823:KIF4A
uniprot id: A0A4X1VZK4
uniprot id: F1RTL0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:MGAT1
gene id: 9823:MGAT1
uniprot id: A0A4X1TB13
uniprot id: Q0KKC2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

9823:GPN2
gene id: 9823:GPN2
uniprot id: Q58DD9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Heterodimers with GPN1 or GPN3. Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
messages: Was originally thought to originate from Bos taurus.

9823:CREM
gene id: 9823:CREM
uniprot id: A0A4X1TG92
uniprot id: A0A4X1TK85
uniprot id: A0A4X1TKQ4
uniprot id: A0A8D0JHR4
uniprot id: A0A8D0ML77
uniprot id: A0A8D0R2H8
uniprot id: A0A8D1C0U7
uniprot id: A0A8D1VM45
names: Subcellular Location Annotation
messages: Nucleus

9823:CRBN
gene id: 9823:CRBN
uniprot id: A0A4X1V0S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9823:EHD2
gene id: 9823:EHD2
uniprot id: A0A8D0QZ29
uniprot id: I3LD72
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9823:NAPEPLD
gene id: 9823:NAPEPLD
uniprot id: A0A4X1VBA4
uniprot id: A0A8D0LWH7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

9823:COX6A1
gene id: 9823:COX6A1
uniprot id: A0A8D0KDL7
uniprot id: A0A8D1LI22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9823:DPM2
gene id: 9823:DPM2
uniprot id: A0A287B2D7
uniprot id: A0A4X1U6E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

9823:TWF1
gene id: 9823:TWF1
uniprot id: A0A8D1TW92
uniprot id: F1SGZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9823:U2AF2
gene id: 9823:U2AF2
uniprot id: A0A8D1GXD7
uniprot id: I3W8V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

9823:F8
gene id: 9823:F8
uniprot id: P12263
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
messages: Interacts with vWF. vWF binding is essential for the stabilization of F8 in circulation (By similarity).
messages: Proteolytically cleaved by cathepsin CTSG to produce a partially activated form.
messages: extracellular space

9823:ACOT13
gene id: 9823:ACOT13
uniprot id: A0A8D0RI54
names: Similarity
messages: Belongs to the thioesterase PaaI family.

9823:MOGS
gene id: 9823:MOGS
uniprot id: A0A8D1FC89
uniprot id: K7N7E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

9823:PGA5
gene id: 9823:PGA5
uniprot id: A1YM35
names: Similarity
messages: Belongs to the peptidase A1 family.

9823:ZNF408
gene id: 9823:ZNF408
uniprot id: A0A8D1RQ43
names: Subcellular Location Annotation
messages: Nucleus

9823:POLR3A
gene id: 9823:POLR3A
uniprot id: A0A4X1SJU1
uniprot id: A0A8D1SC59
uniprot id: F1S2E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9823:VCP
gene id: 9823:VCP
uniprot id: P03974
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Endoplasmic reticulum
messages: Homohexamer. Forms a ring-shaped particle of 12.5 nm diameter, that displays 6-fold radial symmetry. Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Binds to a heterodimer of NPLOC4 and UFD1, binding to this heterodimer inhibits Golgi-membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Part of a ternary complex containing NPLOC4, UFD1 and VCP. Interacts with NSFL1C-like protein p37; the complex has membrane fusion activity and is required for Golgi and endoplasmic reticulum biogenesis. Interacts with SELENOS and SYVN1, as well as with DERL1 (via SHP-box motif), DERL2 and DERL3; which probably transfer misfolded proteins from the ER to VCP. Interacts with SVIP. Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Directly interacts with UBXN4 and RNF19A. Interacts with CASR. Interacts with UBE4B and YOD1. Interacts with clathrin. Interacts with RNF103. Interacts with TRIM13 and TRIM21. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of the endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Interacts directly with AMFR/gp78 (via its VIM). Interacts with RHBDD1 (via C-terminal domain). Interacts with SPRTN; leading to recruitment to stalled replication forks. Interacts with WASHC5. Interacts with UBOX5. Interacts (via N-terminus) with UBXN7, UBXN8, and probably several other UBX domain-containing proteins (via UBX domains); the interactions are mutually exclusive with VIM-dependent interactions such as those with AMFR and SELENOS. Forms a complex with UBQLN1 and UBXN4. Interacts (via the PIM motif) with RNF31 (via the PUB domain). Interacts with RIGI and RNF125; interaction takes place …
messages: ISGylated.
messages: Methylation at Lys-315 catalyzed by VCPKMT is increased in the presence of ASPSCR1. Lys-315 methylation may decrease ATPase activity.
messages: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Involved in clearance process by mediating G3BP1 extraction from stress granules. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis. Involved in interstrand cross-link repair in response to replication stress by med…
messages: Nucleus
messages: Phosphorylated by tyrosine kinases in response to T-cell antigen receptor activation. Phosphorylated in mitotic cells.
messages: Stress granule
messages: Valosin is an artifact of purification procedure, generated in vitro by cleavage of the whole protein upon acid extraction of tissues.
messages: cytosol

9823:CXXC1
gene id: 9823:CXXC1
uniprot id: A0A4X1UJF4
uniprot id: A0A4X1UKR5
uniprot id: F1RPP3
names: Subcellular Location Annotation
messages: Nucleus

9823:GARS
gene id: 9823:GARS
uniprot id: A0A4X1T5Y1
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

9823:PHF1
gene id: 9823:PHF1
uniprot id: A0A287BCT8
uniprot id: A0A8D0NID3
uniprot id: A0A8D1GTH5
uniprot id: F1RZR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9823:WFDC2
gene id: 9823:WFDC2
uniprot id: Q8MI69
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Broad range protease inhibitor.
messages: Detected in the distal parts of the epididymis.
messages: Homotrimer; disulfide-linked.
messages: Secreted

9823:GJD2
gene id: 9823:GJD2
uniprot id: A0A287AL56
uniprot id: A0A8D1QXL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:GPR65
gene id: 9823:GPR65
uniprot id: A0A4X1T012
uniprot id: A0A8D0PJP4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:DDR2
gene id: 9823:DDR2
uniprot id: A0A4X1VMV8
names: Subcellular Location Annotation
messages: Membrane

9823:DPY30
gene id: 9823:DPY30
uniprot id: A0A8D1QEB8
uniprot id: F2Z5F7
names: Similarity
messages: Belongs to the dpy-30 family.

9823:LOC100521659
gene id: 9823:LOC100521659
uniprot id: A0A4X1W8J5
uniprot id: F1SLE8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:GPR20
gene id: 9823:GPR20
uniprot id: A0A4X1SH50
uniprot id: I3LP87
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:UBE2D3
gene id: 9823:UBE2D3
uniprot id: Q06AA9
names: Function
names: Similarity
names: Subunit
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3. Interacts with PPP1R11.

9823:NKX3-2
gene id: 9823:NKX3-2
uniprot id: A0A286ZVB8
uniprot id: A0A8D1I2L2
names: Subcellular Location Annotation
messages: Nucleus

9823:C14H12orf65
gene id: 9823:C14H12orf65
uniprot id: A0A4X1UGG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9823:MT3
gene id: 9823:MT3
uniprot id: P55944
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).
messages: Brain.

9823:ANKRD34B
gene id: 9823:ANKRD34B
uniprot id: A0A8D1ZXH1
uniprot id: F1RF21
names: Similarity
messages: Belongs to the ANKRD34 family.

9823:SLC12A2
gene id: 9823:SLC12A2
uniprot id: A0A287AEN4
uniprot id: A0A480HW11
uniprot id: A0A8D1HWQ0
uniprot id: A0A8D1UYF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9823:RPL15
gene id: 9823:RPL15
uniprot id: A0A286ZL65
uniprot id: A0A8D1E9R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Cytoplasm

9823:H3F3A
gene id: 9823:H3F3A
uniprot id: K9IWF3
uniprot id: Q71LE2
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed throughout the cell cycle independently of DNA synthesis.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains (By similarity). Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). Interacts with ASF1A, MCM2, NASP and SPT2 (By similarity).
messages: Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

9823:TNFRSF9
gene id: 9823:TNFRSF9
uniprot id: A0A288CFZ9
uniprot id: A0A4X1W2S3
uniprot id: A0A5K1VKG5
uniprot id: A0A8D2CEL2
uniprot id: F1RII3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:JAK2
gene id: 9823:JAK2
uniprot id: O19064
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813. Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase activity. Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to growth hormone (GH) are required for maximal kinase activity. Also phosphorylated by TEC (By similarity). Phosphorylated on tyrosine residues in response to interferon gamma signaling. Phosphorylated on tyrosine residues in response to a signaling cascade that is activated by increased cellular retinol (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Cytoplasm
messages: Endomembrane system
messages: Interacts with IL23R, SKB1 and STAM2 (By similarity). Interacts with EPOR. Interacts with LYN. Interacts with SIRPA. Interacts with SH2B1. Interacts with TEC (By similarity). Interacts with IFNGR2 (via intracellular domain) (By similarity). Interacts with LEPR (Isoform B) (By similarity). Interacts with HSP90AB1; promotes functional activation in a heat shock-dependent manner. Interacts with STRA6 (By similarity). Interacts with ASB2; the interaction targets JAK2 for Notch-induced proteasomal degradation (By similarity).
messages: Mn(2+) was used in the in vitro kinase assay but Mg(2+) is likely to be the in vivo cofactor.
messages: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
messages: Nucleus
messages: Regulated by autophosphorylation, can both activate or decrease activity. Heme regulates its activity by enhancing the phosphorylation on Tyr-1007 and Tyr-1008.
messages: The N-terminal domain of JAKs mediates their interaction with cytokine/interferon/growth hormone receptors. Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for protein kinase 1 (By similarity).
messages: Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate-recognition components of probable ECS E3 ubiquitin-protein ligase complexes.

9823:PEX2
gene id: 9823:PEX2
uniprot id: A0A480E925
uniprot id: A0A8D0QUW9
uniprot id: A0A8D1L0G1
uniprot id: F1RWL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9823:FOXJ1
gene id: 9823:FOXJ1
uniprot id: A0A8D1JDT5
uniprot id: F1RWM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FOXJ1 family.
messages: Nucleus

9823:BZW1
gene id: 9823:BZW1
uniprot id: A0A4X1VBP9
uniprot id: A0A8D0UG98
names: Similarity
messages: Belongs to the BZW family.

9823:LIPM
gene id: 9823:LIPM
uniprot id: A0A4X1V5I0
uniprot id: A0A8D0NX33
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9823:COPS8
gene id: 9823:COPS8
uniprot id: A0A8D0U0L0
uniprot id: A0A8D0YG61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9823:MRAP2
gene id: 9823:MRAP2
uniprot id: A0A287A4A0
uniprot id: A0A8D2C8J7
uniprot id: I3LK27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LOC100624876
gene id: 9823:LOC100624876
uniprot id: A0A8D1XAK3
uniprot id: I3LQ89
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ZAN
gene id: 9823:ZAN
uniprot id: Q28983
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
messages: Cell membrane
messages: During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
messages: In testis, primarily in haploid spermatids. Not in lung, liver, heart, spleen, brain, kidney, epididymis.
messages: Probably forms covalent oligomers.
messages: The MAM domains and the mucin-like domains are missing from the zonadhesin that binds to the egg extracellular matrix. Processing might occur during sperm maturation and/or capacitation.
messages: The MAM domains probably mediate sperm adhesion to the zona pellucida.
messages: The VWFD domains 2 and 3 may mediate covalent oligomerization (By similarity to human intestinal mucin MUC2).

9823:SMYD2
gene id: 9823:SMYD2
uniprot id: C3RZA1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: During fetal muscle development, expression increases from 33 to 90 dpc.
messages: Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1. Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1 (By similarity).
messages: Nucleus
messages: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
messages: cytosol

9823:CYP3A46
gene id: 9823:CYP3A46
uniprot id: A7KZR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9823:HSPD1
gene id: 9823:HSPD1
uniprot id: G9F6X6
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9823:PDHA1
gene id: 9823:PDHA1
uniprot id: A0A480VQH5
uniprot id: A0A4X1V4S1
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9823:EFNB3
gene id: 9823:EFNB3
uniprot id: A0A8D0YA40
uniprot id: A0A8D1L793
uniprot id: B0LDT4
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:NUPR2
gene id: 9823:NUPR2
uniprot id: A0A4X1T0T0
uniprot id: A0A8W4FP99
names: Similarity
messages: Belongs to the NUPR family.

9823:PLPPR3
gene id: 9823:PLPPR3
uniprot id: A0A287BF79
uniprot id: A0A8D1FPF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9823:CHEK1
gene id: 9823:CHEK1
uniprot id: A0A8D1J910
uniprot id: F1S774
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9823:PIP4K2A
gene id: 9823:PIP4K2A
uniprot id: O13010
names: Activity Regulation
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (By similarity). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer. Interacts with PIP4K2B; the interaction may regulate localization to the nucleus (By similarity). Probably interacts with PIP5K1A; the interaction inhibits PIP5K1A kinase activity (By similarity).
messages: In rod outer segments, activated by light.
messages: Lysosome
messages: Nucleus
messages: Phosphorylated in tyrosines. Phosphorylation is induced by light and increases kinase activity.
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9823:FAM118A
gene id: 9823:FAM118A
uniprot id: A0A8D1S1F1
uniprot id: A0A8D2C8E0
uniprot id: F1SM57
uniprot id: I3LVE8
names: Similarity
messages: Belongs to the FAM118 family.

9823:RHCE
gene id: 9823:RHCE
uniprot id: A0A4X1VTK0
uniprot id: Q8SQH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9823:PPP3CA
gene id: 9823:PPP3CA
uniprot id: A0A8D1SEU2
uniprot id: Q95MZ3
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9823:PRNP
gene id: 9823:PRNP
uniprot id: P49927
uniprot id: Q5PSB2
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prion family.
messages: Cell membrane
messages: Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.
messages: Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
messages: Golgi apparatus
messages: Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
messages: Membrane
messages: Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement. Interacts with KIAA1191.
messages: The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization.

9823:CRYZ
gene id: 9823:CRYZ
uniprot id: A0A8D1NKG2
uniprot id: Q19QT8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9823:OPRM1
gene id: 9823:OPRM1
uniprot id: Q95247
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms). Interacts with heterotrimeric G proteins; interaction with a heterotrimeric complex containing GNAI1, GNB1 and GNG2 stabilizes the active conformation of the receptor and increases its affinity for endomorphin-2, the synthetic opioid peptide DAMGO and for morphinan agonists (By similarity). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS and GPM6A (By similarity). Interacts with RTP4 (By similarity). Interacts with SYP and GNAS (By similarity). Interacts with RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1.
messages: Perikaryon
messages: Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated phosphorylation modulates receptor internalization. Phosphorylated by GRK2 in a agonist-dependent manner. Phosphorylation at Tyr-169 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on tyrosine residues; the phosphorylation is involved in agonist-induced G-protein-independent receptor down-regulation. Phosphorylation at Ser-378 is involved in G-protein-dependent but not beta-arrestin-dependent activation of the ERK pathway (By similarity).
messages: Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a bet…
messages: Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
messages: axon
messages: dendrite

9823:KCNK3
gene id: 9823:KCNK3
uniprot id: A0A8D2C2P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9823:SLA-7
gene id: 9823:SLA-7
uniprot id: A0A8D0TTC6
uniprot id: A0A8D1S9M0
uniprot id: Q6S7D2
names: Similarity
messages: Belongs to the MHC class I family.

9823:LVRN
gene id: 9823:LVRN
uniprot id: A0A5G2QQR1
uniprot id: A0A8D0S272
uniprot id: A0A8D1XGG9
uniprot id: F1RLE3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9823:ITGA5
gene id: 9823:ITGA5
uniprot id: A0A8D0WPM3
uniprot id: F1SR53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9823:UPK1B
gene id: 9823:UPK1B
uniprot id: A0A8D1YDD5
uniprot id: Q06AT4
names: Subcellular Location Annotation
messages: Membrane

9823:ANAPC16
gene id: 9823:ANAPC16
uniprot id: A0A4X1T7C5
uniprot id: A0A8D0TKE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9823:GPR119
gene id: 9823:GPR119
uniprot id: A0A8D1VBN6
uniprot id: F1RTG3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:LHX9
gene id: 9823:LHX9
uniprot id: A0A480K424
uniprot id: A0A4X1SPP8
uniprot id: A0A8D0K3A2
uniprot id: A0A8D0N9S0
uniprot id: F1S5F5
names: Subcellular Location Annotation
messages: Nucleus

9823:MRPS31
gene id: 9823:MRPS31
uniprot id: A0A4X1SQW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

9823:CHGA
gene id: 9823:CHGA
uniprot id: A0A480ZDS7
uniprot id: P04404
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Binds calcium with a low-affinity.
messages: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.
messages: Inhibits low calcium-stimulated parathyroid cell secretion.
messages: O-glycosylated; contains chondroitin sulfate (CS). CS attachment is pH-dependent, being observed at mildly acidic conditions of pH 5 but not at neutral pH, and promotes self-assembly in vitro.
messages: Parathyroid CHGA is sulfated on tyrosine residues, whereas adrenal CHGA seems to be mainly sulfated on oligosaccharide residues.
messages: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
messages: Secreted
messages: Self-interacts; self-assembly is promoted in vitro by chondroitin sulfate attachment which occurs at mildly acidic pH conditions (By similarity). Interacts with SCG3 (By similarity).
messages: Strongly inhibits glucose induced insulin release from the pancreas.
messages: neuronal dense core vesicle
messages: secretory vesicle

9823:LOC100157017
gene id: 9823:LOC100157017
uniprot id: A0A287A5X0
uniprot id: A0A4X1SD82
uniprot id: A0A4X1SDY3
uniprot id: A0A8D0IXD5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9823:DUOX2
gene id: 9823:DUOX2
uniprot id: Q8HZK2
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: By forskolin and down-regulated by iodide (at protein level). By insulin.
messages: Cell junction
messages: Expressed in thyroid, and the digestive tract especially in stomach, cecum and sigmoidal colon (at protein level). Expressed in thyroid.
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: Heterodimer with DUOXA2; disulfide-linked. Interacts with TXNDC11, TPO and CYBA.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: N-glycosylated.
messages: The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide (By similarity).

9823:LGI3
gene id: 9823:LGI3
uniprot id: A0A287BHH5
uniprot id: A0A8D2CIN8
names: Subcellular Location Annotation
messages: Secreted

9823:SELENOM
gene id: 9823:SELENOM
uniprot id: C4PK53
names: Similarity
messages: Belongs to the selenoprotein M/F family.

9823:MRPS5
gene id: 9823:MRPS5
uniprot id: A0A8D0T5P4
uniprot id: F1SU66
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9823:DSE
gene id: 9823:DSE
uniprot id: A0A8D1WV63
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9823:DEFB110
gene id: 9823:DEFB110
uniprot id: A0A8D1VTV9
uniprot id: Q6SC67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:USP51
gene id: 9823:USP51
uniprot id: A0A4X1VGU6
uniprot id: F1RTR5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:MAP1LC3B
gene id: 9823:MAP1LC3B
uniprot id: A0A4X1T8W3
uniprot id: D7RA29
names: Similarity
messages: Belongs to the ATG8 family.

9823:LOC100158121
gene id: 9823:LOC100158121
uniprot id: A0A8D1QBH6
uniprot id: F2Z587
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:VEGFA
gene id: 9823:VEGFA
uniprot id: A0A4X1V7P2
uniprot id: P49151
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
messages: Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (By similarity). Interacts with BSG (By similarity).
messages: Secreted

9823:VAMP1
gene id: 9823:VAMP1
uniprot id: A0A480QIH1
uniprot id: A0A8D1RB52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9823:LAMTOR3
gene id: 9823:LAMTOR3
uniprot id: A0A4X1UJ60
uniprot id: A0A8D1FWE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9823:TIMM13
gene id: 9823:TIMM13
uniprot id: A0A4X1VSY2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9823:RABAC1
gene id: 9823:RABAC1
uniprot id: A0A4X1SGI1
uniprot id: A0A8D1EL12
uniprot id: Q52NJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA1 family.
messages: Cell membrane
messages: Cytoplasm
messages: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1.
messages: Golgi apparatus
messages: Homodimer. Interacts with VAMP2 (synaptobrevin-2), prenylated Rab proteins, GDI1, NRDG1 and PCLO (By similarity).
messages: Membrane
messages: synaptic vesicle

9823:ENY2
gene id: 9823:ENY2
uniprot id: A0A4X1TFA2
uniprot id: A0A8D0Z7Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9823:CYR61
gene id: 9823:CYR61
uniprot id: A0A4X1UFQ6
uniprot id: A0A5G2QS80
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:CCNJ
gene id: 9823:CCNJ
uniprot id: A0A4X1UHM5
uniprot id: A0A8D0M9X5
names: Similarity
messages: Belongs to the cyclin family.

9823:C14H10orf99
gene id: 9823:C14H10orf99
uniprot id: I3LGZ3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus.
messages: Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May regulate keratinocyte proliferation. In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (By similarity).
messages: Interacts with SUSD2; the interaction is direct.
messages: Secreted

9823:LOC100624226
gene id: 9823:LOC100624226
uniprot id: A0A286ZQG3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:PSMG1
gene id: 9823:PSMG1
uniprot id: A0A8D0QPY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9823:CNTF
gene id: 9823:CNTF
uniprot id: A0A8D1R2M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

9823:GYS1
gene id: 9823:GYS1
uniprot id: E0X6R2
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9823:LOC100513516
gene id: 9823:LOC100513516
uniprot id: A0A4X1W476
uniprot id: F1RTG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:HEXIM1
gene id: 9823:HEXIM1
uniprot id: A0A5G2RFM4
uniprot id: A0A8D0RYW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9823:CFB
gene id: 9823:CFB
uniprot id: A0A8D0Q4G6
uniprot id: A5PF00
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:ARL11
gene id: 9823:ARL11
uniprot id: A0A8D1UL23
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9823:INSIG1
gene id: 9823:INSIG1
uniprot id: A0A4X1U6V6
uniprot id: F1SHU4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9823:UBN1
gene id: 9823:UBN1
uniprot id: A0A4X1VLG2
uniprot id: A0A4X1VQM9
uniprot id: A0A8D0UBQ4
uniprot id: A0A8D1DWM4
names: Similarity
messages: Belongs to the ubinuclein family.

9823:HEATR5B
gene id: 9823:HEATR5B
uniprot id: A0A4X1T2S3
names: Similarity
messages: Belongs to the HEATR5 family.

9823:GPHA2
gene id: 9823:GPHA2
uniprot id: A0A8D1VV97
names: Caution
names: Function
names: Similarity
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9823:LOC100737744
gene id: 9823:LOC100737744
uniprot id: F1RHT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CFTR
gene id: 9823:CFTR
uniprot id: Q6PQZ2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer (PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).
messages: N-glycosylated.
messages: Nucleus
messages: Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.
messages: Recycling endosome membrane
messages: The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, NHERF1/EBP50 complex.
messages: The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.
messages: Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity).

9823:EMX2
gene id: 9823:EMX2
uniprot id: A0A8D1NRH5
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100621552
gene id: 9823:LOC100621552
uniprot id: A0A287BDG3
uniprot id: A0A8D1Z9V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:YIPF1
gene id: 9823:YIPF1
uniprot id: A0A287ASC2
uniprot id: A0A8D0XZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9823:INSL5
gene id: 9823:INSL5
uniprot id: A0A480EQQ5
uniprot id: A0A4X1TZH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9823:TAS1R3
gene id: 9823:TAS1R3
uniprot id: A0A4X1W3A9
uniprot id: F1RJE6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:SIDT2
gene id: 9823:SIDT2
uniprot id: A0A4X1SY28
uniprot id: A0A4X1SYJ8
uniprot id: A0A5G2RB28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9823:DVL1
gene id: 9823:DVL1
uniprot id: A0A4X1WAB8
uniprot id: F1RJE5
names: Similarity
messages: Belongs to the DSH family.

9823:PRDM12
gene id: 9823:PRDM12
uniprot id: A0A4X1TCS3
uniprot id: F1S0X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Involved in the positive regulation of histone H3-K9 dimethylation.
messages: Nucleus

9823:TXK
gene id: 9823:TXK
uniprot id: A0A4X1UHV6
uniprot id: A0A4X1UJL4
uniprot id: F1SEA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:UBIAD1
gene id: 9823:UBIAD1
uniprot id: A0A287B839
uniprot id: A0A8D1WYG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9823:P3H3
gene id: 9823:P3H3
uniprot id: F1SLU9
names: Similarity
messages: Belongs to the leprecan family.

9823:B4GALT7
gene id: 9823:B4GALT7
uniprot id: A0A4X1VRF9
uniprot id: D1H0P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9823:SARAF
gene id: 9823:SARAF
uniprot id: A0A287AGS1
uniprot id: A0A8D0SMA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9823:CYP17A1
gene id: 9823:CYP17A1
uniprot id: P19100
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity.

9823:KCNV2
gene id: 9823:KCNV2
uniprot id: A0A4X1W8Q8
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100525119
gene id: 9823:LOC100525119
uniprot id: A0A4X1VIM1
uniprot id: F1S9N3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:BSCL2
gene id: 9823:BSCL2
uniprot id: A0A4X1VLP2
uniprot id: A0A4X1VN05
uniprot id: B2LVD1
uniprot id: B8Y8D6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LOC100738859
gene id: 9823:LOC100738859
uniprot id: A0A287BID4
uniprot id: A0A8D0MDG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:SLA-1
gene id: 9823:SLA-1
uniprot id: A0A0A7BZR3
uniprot id: A1YH77
names: Similarity
messages: Belongs to the MHC class I family.

9823:HOXB8
gene id: 9823:HOXB8
uniprot id: A0A4X1UQX1
uniprot id: F1RWG3
names: Subcellular Location Annotation
messages: Nucleus

9823:OXTR
gene id: 9823:OXTR
uniprot id: A0A4X1V1T1
uniprot id: A0A8D1HKV9
uniprot id: P32306
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

9823:PPP4R3A
gene id: 9823:PPP4R3A
uniprot id: A0A4X1SQV3
uniprot id: F1SD90
names: Similarity
messages: Belongs to the SMEK family.

9823:CD4
gene id: 9823:CD4
uniprot id: I3L556
names: Subcellular Location Annotation
messages: Cell membrane

9823:EIF3A
gene id: 9823:EIF3A
uniprot id: A0A8D1ETP6
uniprot id: F1S4P6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with EIF4G1. Also interacts with KRT7 and PIWIL2.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

9823:BMP15
gene id: 9823:BMP15
uniprot id: F1RV73
uniprot id: Q8WMY6
names: Similarity
messages: Belongs to the TGF-beta family.

9823:C1H9orf78
gene id: 9823:C1H9orf78
uniprot id: A0A8D1BG90
uniprot id: F1RQE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLS1 family.
messages: Nucleus

9823:CAPZA2
gene id: 9823:CAPZA2
uniprot id: A0PFK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9823:TTC39C
gene id: 9823:TTC39C
uniprot id: A0A4X1VND1
uniprot id: F1SBB2
names: Similarity
messages: Belongs to the TTC39 family.

9823:AGPAT1
gene id: 9823:AGPAT1
uniprot id: Q460L6
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9823:TAS1R2
gene id: 9823:TAS1R2
uniprot id: I1ZBR6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:SLC6A8
gene id: 9823:SLC6A8
uniprot id: C6KE31
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.
messages: Cell membrane
messages: Membrane

9823:SERPINE2
gene id: 9823:SERPINE2
uniprot id: A0A4X1U5V7
uniprot id: A0A8D1D3U6
names: Similarity
messages: Belongs to the serpin family.

9823:TWF2
gene id: 9823:TWF2
uniprot id: A0A4X1VPA1
uniprot id: A0A8D1EG15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9823:CYP2C42
gene id: 9823:CYP2C42
uniprot id: A0A480QNA8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:MGAT4C
gene id: 9823:MGAT4C
uniprot id: Q6ITT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity).
messages: Golgi apparatus membrane

9823:HLCS
gene id: 9823:HLCS
uniprot id: A0A8D1MTH1
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9823:NPPC
gene id: 9823:NPPC
uniprot id: P18104
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Degraded by IDE (in vitro).
messages: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3 (By similarity).
messages: Secreted

9823:WDR55
gene id: 9823:WDR55
uniprot id: A0A8D1D656
uniprot id: F1RGE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

9823:NF2
gene id: 9823:NF2
uniprot id: A0A480KT19
uniprot id: A0A4X1V8X9
uniprot id: A0A8D0U9C9
uniprot id: A0A8D0WV25
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9823:RAB18
gene id: 9823:RAB18
uniprot id: A0A4X1U5P7
uniprot id: I3LC07
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9823:LOC102167841
gene id: 9823:LOC102167841
uniprot id: A0A4X1V306
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NKX3-1
gene id: 9823:NKX3-1
uniprot id: A0A287BML5
uniprot id: A0A8D1EQC2
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100517176
gene id: 9823:LOC100517176
uniprot id: A0A287AX23
uniprot id: A0A8D1YXN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SNCB
gene id: 9823:SNCB
uniprot id: A0A4X1SIN8
uniprot id: A8QW48
names: Similarity
messages: Belongs to the synuclein family.

9823:MINOS1
gene id: 9823:MINOS1
uniprot id: A0A481AS71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9823:ELOA
gene id: 9823:ELOA
uniprot id: A0A8D1FSM7
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100523079
gene id: 9823:LOC100523079
uniprot id: A0A287BPR8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:REXO2
gene id: 9823:REXO2
uniprot id: A0A286ZIZ9
uniprot id: A0A4X1T1G5
names: Similarity
messages: Belongs to the oligoribonuclease family.

9823:NDUFB1
gene id: 9823:NDUFB1
uniprot id: A0A8D1J6F0
uniprot id: A0A8D2CGH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:NARF
gene id: 9823:NARF
uniprot id: F1S011
names: Similarity
messages: Belongs to the NARF family.

9823:PNLIPRP2
gene id: 9823:PNLIPRP2
uniprot id: D7EZN2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:23770034). In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (PubMed:23770034). Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:23770034). Can completely deacylate triacylglycerols (By similarity). When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase (By similarity). Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (By similarity). Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides (By similarity). Hydrolyzes long-chain monoglycerides with high efficiency (By similarity). In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity (PubMed:23770034). In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).
messages: Secreted
messages: Up-regulated by CLPS in the presence of increasing concentrations of bile salts.
messages: Zymogen granule membrane
messages: neuron projection

9823:ACTL9
gene id: 9823:ACTL9
uniprot id: A0A4X1VLN3
uniprot id: F1SA46
names: Similarity
messages: Belongs to the actin family.

9823:FAM126A
gene id: 9823:FAM126A
uniprot id: A0A4X1T583
uniprot id: A0A8D0Y359
uniprot id: F1SBZ3
uniprot id: I3LJX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9823:NCLN
gene id: 9823:NCLN
uniprot id: A0A481CWD2
uniprot id: A0A4X1VSQ7
uniprot id: A0A4X1VTC6
uniprot id: A0A8D1MY07
uniprot id: F1S8E9
names: Function
names: Similarity
messages: Belongs to the nicastrin family.
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

9823:LOC106504908
gene id: 9823:LOC106504908
uniprot id: A0A5G2QTX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PLCB4
gene id: 9823:PLCB4
uniprot id: A0A287BD89
uniprot id: A0A8D1CIQ7
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9823:SLC35C1
gene id: 9823:SLC35C1
uniprot id: A0A4X1SER9
uniprot id: A0A8D0X2S5
uniprot id: A0A8D1J1L0
uniprot id: F1SHJ7
names: Subcellular Location Annotation
messages: Membrane

9823:IL13RA1
gene id: 9823:IL13RA1
uniprot id: Q863Z6
names: Subcellular Location Annotation
messages: Membrane

9823:MAPK6
gene id: 9823:MAPK6
uniprot id: A0A8D0IX08
uniprot id: F1RZB8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9823:A4GNT
gene id: 9823:A4GNT
uniprot id: A0A4X1TK07
uniprot id: I3LSM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9823:TMEM200B
gene id: 9823:TMEM200B
uniprot id: A0A4X1SX25
uniprot id: A0A8W4FAK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9823:IFN-OMEGA-4
gene id: 9823:IFN-OMEGA-4
uniprot id: A0A4X1WC30
uniprot id: C8CKC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:CLPS
gene id: 9823:CLPS
uniprot id: D5KJH8
uniprot id: P02703
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the colipase family.
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Expressed by the pancreas.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9823:PSIP1
gene id: 9823:PSIP1
uniprot id: A0A4X1W5S3
uniprot id: A0A8D1HFQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9823:SEPT11
gene id: 9823:SEPT11
uniprot id: A0A173G6G6
uniprot id: A0A287AFS4
uniprot id: A0A4X1SW97
uniprot id: A0A8D1G7M0
uniprot id: A0A8D1TYU6
uniprot id: A0A8W4F7D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9823:SPPL2B
gene id: 9823:SPPL2B
uniprot id: A0A287BCL8
uniprot id: A0A480EN37
uniprot id: A0A4X1VN26
uniprot id: A0A8D1E4T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

9823:PLA1A
gene id: 9823:PLA1A
uniprot id: A0A287BC40
uniprot id: A0A481CXY7
uniprot id: A0A8D1IC58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9823:CENPQ
gene id: 9823:CENPQ
uniprot id: A0A8D0I8X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

9823:GJA5
gene id: 9823:GJA5
uniprot id: A0A8D0PC11
uniprot id: F1SDC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:YPEL5
gene id: 9823:YPEL5
uniprot id: A0A4X1TCI2
uniprot id: A0A8D0SK01
names: Similarity
messages: Belongs to the yippee family.

9823:SPMI
gene id: 9823:SPMI
uniprot id: A0A8D0XIF2
uniprot id: I7HJH6
names: Caution
names: Similarity
messages: Belongs to the spermadhesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:SOD3
gene id: 9823:SOD3
uniprot id: Q007T6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

9823:ST8SIA2
gene id: 9823:ST8SIA2
uniprot id: A0A4X1UGP8
uniprot id: M1FW61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9823:IRF5
gene id: 9823:IRF5
uniprot id: K9J6J1
names: Subcellular Location Annotation
messages: Nucleus

9823:TUBB2B
gene id: 9823:TUBB2B
uniprot id: A0A287AGU7
uniprot id: A0A8D1UIR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9823:TRAPPC5
gene id: 9823:TRAPPC5
uniprot id: A0A4X1VNE1
uniprot id: F1SCJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: cis-Golgi network

9823:SNRPA1
gene id: 9823:SNRPA1
uniprot id: A0A480UFC4
uniprot id: A0A4X1U918
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9823:LOC100519808
gene id: 9823:LOC100519808
uniprot id: A0A287AH66
uniprot id: A0A287APH1
uniprot id: A0A4X1UVM9
uniprot id: A0A8D1G401
names: Similarity
messages: Belongs to the TCAF family.

9823:BSX
gene id: 9823:BSX
uniprot id: A0A4X1VIV4
uniprot id: F1S9Q4
names: Subcellular Location Annotation
messages: Nucleus

9823:ACTA1
gene id: 9823:ACTA1
uniprot id: A0A480QNI6
uniprot id: P68137
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-75 by SETD3.
messages: Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with alpha-actinin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity). Interacts with TTID. Interacts (via its C-terminus) with USP25 (By similarity).
messages: cytoskeleton

9823:JAKMIP1
gene id: 9823:JAKMIP1
uniprot id: A0A480IS38
uniprot id: A0A4X1SLJ9
names: Similarity
messages: Belongs to the JAKMIP family.

9823:NDST2
gene id: 9823:NDST2
uniprot id: A0A4X1SY66
uniprot id: A0A8D1BH74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9823:SLC4A1
gene id: 9823:SLC4A1
uniprot id: A0A8D1HL68
uniprot id: K7GR72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

9823:SMIM15
gene id: 9823:SMIM15
uniprot id: A0A287BL25
uniprot id: A0A8D0MI71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9823:ARR3
gene id: 9823:ARR3
uniprot id: A0A4X1VZR9
uniprot id: A0A8D1MMV8
uniprot id: Q7YS78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arrestin family.
messages: Homodimer; disulfide-linked in response to retinal illumination (By similarity). Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4 (By similarity).
messages: May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins (By similarity).
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9823:C1H18orf25
gene id: 9823:C1H18orf25
uniprot id: A0A287A2F4
uniprot id: A0A4X1USU5
uniprot id: A0A8D1LJF2
uniprot id: F1RPS7
names: Subcellular Location Annotation
messages: Nucleus

9823:EID1
gene id: 9823:EID1
uniprot id: A0A4X1SKU0
uniprot id: F1SQG2
names: Subcellular Location Annotation
messages: Nucleus

9823:TNFSF14
gene id: 9823:TNFSF14
uniprot id: A0A4X1VSJ9
uniprot id: A0A8D0LQZ9
uniprot id: A0A8D0V8G2
uniprot id: A0A8D1V6R8
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:LOC106509345
gene id: 9823:LOC106509345
uniprot id: A0A8D0RHW1
uniprot id: F1RMF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:HSDL2
gene id: 9823:HSDL2
uniprot id: A0A4X1V4W9
names: Subcellular Location Annotation
messages: Peroxisome

9823:PPIL3
gene id: 9823:PPIL3
uniprot id: A0A8D0IQ99
uniprot id: F2Z5T7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9823:SLC25A17
gene id: 9823:SLC25A17
uniprot id: A0A287B1G7
uniprot id: A0A4X1W0U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:METTL11B
gene id: 9823:METTL11B
uniprot id: A0A287B4H2
uniprot id: A0A4X1UK40
uniprot id: A0A8D1IP54
uniprot id: F1RSD2
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9823:TPM2
gene id: 9823:TPM2
uniprot id: A0A4X1VWM4
uniprot id: A0A8D1DIF5
uniprot id: A0A8W4FLZ3
uniprot id: A1X899
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9823:EP300
gene id: 9823:EP300
uniprot id: A0A480QJT4
uniprot id: A0A8D0VBW0
names: Subcellular Location Annotation
messages: Cytoplasm

9823:SLC22A12
gene id: 9823:SLC22A12
uniprot id: A0A4X1VBJ4
uniprot id: A0A8D0VQK0
names: Subcellular Location Annotation
messages: Membrane

9823:RMND1
gene id: 9823:RMND1
uniprot id: A0A5G2QJM3
uniprot id: A0A8D1QZ60
names: Similarity
messages: Belongs to the RMD1/sif2 family.

9823:RIF1
gene id: 9823:RIF1
uniprot id: A0A8D0ZQC0
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9823:ZNF703
gene id: 9823:ZNF703
uniprot id: A0A8D0ZTG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

9823:DLK2
gene id: 9823:DLK2
uniprot id: B2LW77
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Regulates adipogenesis.

9823:LXN
gene id: 9823:LXN
uniprot id: A0A8D1I9F1
uniprot id: I3LN84
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9823:ITGB1
gene id: 9823:ITGB1
uniprot id: A0A4X1TP89
uniprot id: K7GNY7
uniprot id: Q9GLP0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, …
messages: Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner (By similarity). Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB, FLNC and RANBP9. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with RAB21. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with MYO10. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with DAB2. Interacts with FGR and HCK. Isoform 2 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 2 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has a heterodimer form (By similarity). ITGA5:ITGB1 interacts with CCN3 (By similarity). ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (By similarity). ITGA5:ITGB1 interacts with FBN1 (By similarity). ITGA5:ITGB1 interacts with IL1B. Interacts with MDK. ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation. ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite-outg…
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.
messages: Widely expressed.
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle
messages: ruffle membrane

9823:APMAP
gene id: 9823:APMAP
uniprot id: A0A8D2BP17
names: Similarity
messages: Belongs to the strictosidine synthase family.

9823:SNX19
gene id: 9823:SNX19
uniprot id: A0A287BNC7
uniprot id: A0A4X1VAT3
names: Similarity
messages: Belongs to the sorting nexin family.

9823:MCRIP2
gene id: 9823:MCRIP2
uniprot id: A0A4X1SHE9
uniprot id: F1RGT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

9823:BBS5
gene id: 9823:BBS5
uniprot id: A0A287B2N5
uniprot id: A0A8D0SM41
uniprot id: A0A8D1HWF0
uniprot id: A0A8D1P1T1
uniprot id: A0A8D1P1U1
uniprot id: F1S1V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9823:LOC100511183
gene id: 9823:LOC100511183
uniprot id: A0A8D2C3W6
uniprot id: F1S3K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9823:GCLM
gene id: 9823:GCLM
uniprot id: A0A4X1U0N2
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

9823:TIMM17B
gene id: 9823:TIMM17B
uniprot id: A0A5G2R0D0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

9823:GCG
gene id: 9823:GCG
uniprot id: P01274
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glucagon family.
messages: GLP-2 does not have cleavage on a pair of basic residues at C-terminus as in other mammals.
messages: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain.
messages: Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion (By similarity).
messages: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
messages: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
messages: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6. Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis.
messages: Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas (By similarity).
messages: Secreted
messages: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.
messages: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.

9823:TLR2
gene id: 9823:TLR2
uniprot id: A0A8D1VGR5
uniprot id: Q59HI8
uniprot id: Q6TN21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Membrane

9823:CHRNG
gene id: 9823:CHRNG
uniprot id: F1SMT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:TCP11L2
gene id: 9823:TCP11L2
uniprot id: A0A480R7V7
uniprot id: A0A8D0PDG7
names: Similarity
messages: Belongs to the TCP11 family.

9823:LOC100524359
gene id: 9823:LOC100524359
uniprot id: A0A4X1STQ4
uniprot id: A0A8W4FAR8
names: Subcellular Location Annotation
messages: Nucleus

9823:MAP1LC3A
gene id: 9823:MAP1LC3A
uniprot id: A0A8D1YWJ5
uniprot id: D2KQR0
names: Similarity
messages: Belongs to the ATG8 family.

9823:SNRPD3
gene id: 9823:SNRPD3
uniprot id: A0A4X1V3C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9823:PKIA
gene id: 9823:PKIA
uniprot id: Q71U53
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
messages: The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and 'pseudosubstrate site' of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site (By similarity).

9823:CCL25
gene id: 9823:CCL25
uniprot id: Q4PR21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).
messages: Secreted

9823:VTI1B
gene id: 9823:VTI1B
uniprot id: Q6R6K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9823:MTFR1L
gene id: 9823:MTFR1L
uniprot id: A0A4X1VMJ2
uniprot id: A0A8D0JD83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9823:LOC100623024
gene id: 9823:LOC100623024
uniprot id: A0A4X1TXD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CD3D
gene id: 9823:CD3D
uniprot id: Q764N2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells.
messages: Cell membrane
messages: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.
messages: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with coreceptors CD4 and CD8.

9823:SLC13A5
gene id: 9823:SLC13A5
uniprot id: A0A8D0RKL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9823:DDC
gene id: 9823:DDC
uniprot id: B5KFA0
uniprot id: P80041
names: Function
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.
messages: Homodimer.

9823:MB21D1
gene id: 9823:MB21D1
uniprot id: I3LM39
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-359, Lys-369 and Lys-389 inhibits the cyclic GMP-AMP synthase activity. Deacetylated upon cytosolic DNA challenge such as viral infections. Acetylation by KAT5 increases the cyclic GMP-AMP synthase activity by promoting DNA-binding and subsequent activation.
messages: Belongs to the mab-21 family.
messages: Binds 1 Mg(2+) per subunit (PubMed:23722159). Is also active with Mn(2+). Mn(2+)-activated enzyme forms an inverted pppGp(2'-5')A intermediate, suggesting a non-canonical but accelerated 2',3'-cGAMP cyclization without substrate flip-over. Mn(2+) ions are coordinated by triphosphate moiety of the inverted substrate, independent of the catalytic triad residues (PubMed:23722159) (By similarity).
messages: Cell membrane
messages: Chromosome
messages: Degraded via selective autophagy following interaction with IRGM. IRGM promotes CGAS recruitment to autophagosome membranes, promoting its SQSTM1/p62-dependent autophagic degradation.
messages: Monomer in the absence of DNA. Homodimer in presence of dsDNA: forms a 2:2 dimer with two enzymes binding to two DNA molecules. Interacts with nucleosomes; interaction is mainly mediated via histones H2A and H2B and inactivates the nucleotidyltransferase activity by blocking DNA-binding and subsequent activation. Interacts with PQBP1 (via WW domain). Interacts with TRIM14; this interaction recruits USP14, leading to deubiquitinate and stabilize CGAS and promote type I interferon production. Interacts with ZCCHC3; promoting sensing of dsDNA by CGAS. Interacts (when not monomethylated) with (poly-ADP-ribosylated) PARP1; interaction takes place in the nucleus and prevents the formation of the PARP1-TIMELESS complex (By similarity). Interacts (when monomethylated) with SGF29; interaction with SGF29 prevents interaction with PARP1. Interacts with PCBP2; preventing the formation of liquid-like droplets in which CGAS is activated (By similarity). Interacts with IRGM; promoting CGAS degradation (By similarity).
messages: Monomethylated at Lys-481 by SETD7 (By similarity). Monomethylation promotes interaction with SGF29, preventing interaction between PARP1 nad SGF29. Demethylation by RIOX1 promotes interaction with PARP1, followed by PARP1 inactivation (By similarity).
messages: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:23722159). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:23722159). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production. Preferentially binds long dsDNA (around 45 bp) and forms ladder-like networks that function cooperatively to stabilize individual cGAS-dsDNA complexes. Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm. Also acts as an innate immune sensor of infection by retroviruses by detecting the presence of reverse-transcribed DNA in the cytosol (By similarity). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA. Also detects the presence of DNA from bacteria (By similarity). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells. 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner. Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (By simila…
messages: Nucleus
messages: Palmitoylation at Cys-449 by ZDHHC18 impairs DNA-binding, thereby preventing the cyclic GMP-AMP synthase activity.
messages: Poly-ADP-ribosylation at Glu-165 by PARP1 impairs DNA-binding, thereby preventing the cyclic GMP-AMP synthase activity.
messages: Polyglutamylated by TTLL6 at Glu-261, leading to impair DNA-binding activity. Deglutamylated by AGBL5/CCP5 and AGBL6/CCP6.
messages: Proteolytically cleaved by apoptotic caspases during apoptosis, leading to its inactivation. The damage of the nucleus and the mitochondria during apoptosis leads to leakage of nuclear and mitochondrial DNA, which activate CGAS: cleavage and inactivation during apoptosis in required to prevent cytokine overproduction. Cleaved by CASP7 and CASP3 during virus-induced apoptosis, thereby inactivating it and preventing cytokine overproduction. Cleaved by CASP1 upon DNA virus infection; the cleavage impairs cGAMP production. Also cleaved by the pyroptotic CASP4 during non-canonical inflammasome activation; does not cut at the same sites than CASP1.
messages: Sumoylated at Lys-206 by TRIM38 in uninfected cells and during the early phase of viral infection, promoting its stability by preventing ubiquitination at Lys-260 and subsequent degradation. Desumoylated by SENP2 during the late phase of viral infection. Sumoylation at Lys-322, Lys-359 and Lys-369 prevents DNA-binding, oligomerization and nucleotidyltransferase activity. Desumoylation at Lys-322, Lys-359 and Lys-369 by SENP7 relieves inhibition and activates CGAS.
messages: The N-terminal disordered part (1-134) binds unspecifically dsDNA and expands the binding and moving range of CGAS on dsDNA (By similarity). The disordered and positively charged residues enhance CGAS-DNA phase separation by increasing the valencies of DNA-binding. The N-terminus is required to sense chromatin and its phosphorylation blocks its activation by chromatin DNA (By similarity). When the N-terminal part (1-134) is missing the protein bound to dsDNA homodimerizes (By similarity).
messages: The N-terminal disordered part (1-134) is phosphorylated by AURKB during the G2-M transition, blocking CGAS liquid phase separation and preventing activation. Phosphorylation at Tyr-190 by BLK promotes cytosolic retention. Localizes into the nucleus following dephosphorylation at Tyr-190 (By similarity). Phosphorylation at Ser-410 activates the nucleotidyltransferase activity. Dephosphorylation at Ser-410 by PPP6C impairs its ability to bind GTP, thereby inactivating it (By similarity). Phosphorylation at Ser-188 by PRKDC inhibits its cyclic GMP-AMP synthase activity by impairing homodimerization and activation (By similarity). Phosphorylation at Ser-278 by AKT (AKT1, AKT2 or AKT3) suppresses the nucleotidyltransferase activity. Phosphorylation at Ser-278 by CDK1 during mitosis leads to its inhibition, thereby preventing CGAS activation by self-DNA during mitosis. Dephosphorylated at Ser-278 by protein phosphatase PP1 upon mitotic exit (By similarity).
messages: The arginine-anchor tightly binds to the canonical H2A acidic-patch residues.
messages: The enzyme activity is strongly increased by double-stranded DNA (dsDNA), but not by single-stranded DNA or RNA (PubMed:23722159). DNA-binding induces the formation of liquid-like droplets in which CGAS is activated. Liquid-like droplets also create a selective environment that restricts entry of negative regulators, such as TREX1 or BANF1/BAF, allowing sensing of DNA (By similarity). A number of mechanisms exist to restrict its activity toward self-DNA. The nucleotidyltransferase activity is inhibited in the nucleus via its association with nucleosomes: interacts with the acidic patch of histones H2A and H2B, thereby blocking DNA-binding and subsequent activation (By similarity). CGAS is also inactive when associated with mitotic chromatin (By similarity). Chromatin-bound CGAS cannot be activated by exogenous DNA in mitotic cells: phosphorylation of the N-terminal disordered part by AURKB during the G2-M transition blocks CGAS liquid phase separation and activation (By similarity). Activity toward self-DNA is inhibited by BANF1/BAF upon acute loss of nuclear membrane integrity: BANF1/BAF acts by outcompeting CGAS for DNA-binding, thereby preventing CGAS activation (By similarity). DNA-induced activation at micronuclei is also limited by TREX1, which degrades micronuclear DNA upon nuclear envelope rupture, thereby preventing CGAS activation. Acetylation at Lys-359, Lys-369 and Lys-389 inhibits the cyclic GMP-AMP synthase activity. Acetylation by KAT5 increases the cyclic GMP-AMP synthase activity by promoting DNA-binding and subsequent activation (By similarity). Phosphorylation at Ser-278 suppresses the nucleotidyltransferase activity. Phosphorylation at Ser-410 promotes the cyclic GMP-AMP synthase activity (By similarity). Phosphorylation at Ser-188 inhibits its cyclic GMP-AMP synthase activity. Ubiquitination at Lys-359 via 'Lys-27'-linked polyubiquitination enhances the cyclic GMP-AMP synthase activity (By similarity). Monoubiquitination at Lys-322 promotes olig…
messages: Ubiquitinated at Lys-389 via 'Lys-48'-linked polyubiquitin chains, leading to its SQSTM1-mediated autophagic degradation. Interaction with TRIM14 promotes recruitment of USP14, leading to deubiquitinate Lys-389 and stabilize CGAS. Ubiquitinated at Lys-359 by RNF185 via 'Lys-27'-linked polyubiquitination, promoting CGAS cyclic GMP-AMP synthase activity (By similarity). Monoubiquitination at Lys-322 by TRIM56 promotes oligomerization and subsequent activation (By similarity). Monoubiquitination by TRIM41 promotes CGAS activation (By similarity). Ubiquitination at Lys-260 via 'Lys-48'-linked polyubiquitination promotes its degradation. Deubiquitination at Lys-260 by USP29 promotes its stabilization. Deubiquitinated by USP27X, promoting its stabilization (By similarity). Ubiquitinated at Lys-386 via 'Lys-63'-linked polyubiquitin chains by MARCHF8, leading to the inhibition of its DNA binding ability (By similarity).
messages: Undergoes a liquid-like phase transition after binding to DNA, which is dependent on zinc.
messages: cytosol

9823:CLDN23
gene id: 9823:CLDN23
uniprot id: A0A8D0LLJ4
uniprot id: A0A8D0N0M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9823:GDF5
gene id: 9823:GDF5
uniprot id: A0A8D2BTT8
uniprot id: F1S4W8
names: Similarity
messages: Belongs to the TGF-beta family.

9823:AMT
gene id: 9823:AMT
uniprot id: A0A8D0TL78
uniprot id: I3LIR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9823:PTMS
gene id: 9823:PTMS
uniprot id: A0A4X1UU16
names: Similarity
messages: Belongs to the pro/parathymosin family.

9823:ACTR10
gene id: 9823:ACTR10
uniprot id: A0A4X1WCZ5
uniprot id: I3LHK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family.
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
messages: Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6 (PubMed:33734450, PubMed:36071160). The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin (PubMed:25814576, PubMed:33734450, PubMed:36071160, PubMed:29420470).
messages: cytoskeleton

9823:CNGA4
gene id: 9823:CNGA4
uniprot id: A0A8D1UWC4
uniprot id: F1RMM3
names: Subcellular Location Annotation
messages: Membrane

9823:SLA-DRA
gene id: 9823:SLA-DRA
uniprot id: A0A8D0ISX7
uniprot id: Q31065
names: Similarity
messages: Belongs to the MHC class II family.

9823:GFM1
gene id: 9823:GFM1
uniprot id: A0A480EKY5
uniprot id: A0A4X1SGR9
uniprot id: A0A4X1SGY0
uniprot id: I3LKJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9823:GIPC2
gene id: 9823:GIPC2
uniprot id: A0A287BNZ1
uniprot id: A0A4X1UUE4
names: Similarity
messages: Belongs to the GIPC family.

9823:CNRIP1
gene id: 9823:CNRIP1
uniprot id: A0A4X1WA04
uniprot id: F2Z5U6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9823:TTC38
gene id: 9823:TTC38
uniprot id: A0A480V890
uniprot id: A0A4X1W4N0
names: Similarity
messages: Belongs to the TTC38 family.

9823:ANTXR2
gene id: 9823:ANTXR2
uniprot id: A0A8D1CVD7
uniprot id: K9J4T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9823:HAO2
gene id: 9823:HAO2
uniprot id: A0A287BQZ1
uniprot id: A0A8D1VA36
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9823:ADORA1
gene id: 9823:ADORA1
uniprot id: A0A8D1Q4P6
uniprot id: I3LEN5
uniprot id: Q4VQ11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9823:GLUD1
gene id: 9823:GLUD1
uniprot id: A0A480ZB10
uniprot id: A0A4X1VHE8
uniprot id: P42174
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity. Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Endoplasmic reticulum
messages: Homohexamer (By similarity). Interacts with HADH; this interaction inhibits the activation of GLUD1 (By similarity).
messages: Liver, brain and thyroid.
messages: Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:8240242). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
messages: Mitochondrion
messages: Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme. Inhibited by SIRT4 (By similarity). Inhibited by HADH (By similarity).

9823:LOC100519930
gene id: 9823:LOC100519930
uniprot id: A0A4X1UAI6
uniprot id: A0A8D0I751
names: Similarity
messages: Belongs to the histone H2B family.

9823:SPATA18
gene id: 9823:SPATA18
uniprot id: D5K8A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain). Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane.
messages: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).
messages: Mitochondrion outer membrane

9823:CCR10
gene id: 9823:CCR10
uniprot id: A0A4X1TZB5
uniprot id: Q1WL53
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:SLC44A4
gene id: 9823:SLC44A4
uniprot id: A5PF08
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CTL (choline transporter-like) family.
messages: Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (By similarity).
messages: Membrane
messages: N-glycosylated; N-glycosylation of Asn-677 and Asn-390 is required for a proper thiamine pyrophosphate uptake.

9823:GEM
gene id: 9823:GEM
uniprot id: A0A4X1U1R7
uniprot id: A0A4X1U6D0
uniprot id: A0A8D0SS83
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9823:TMEM120B
gene id: 9823:TMEM120B
uniprot id: A0A4X1U3Y9
uniprot id: A0A8D0ZLK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9823:GLE1
gene id: 9823:GLE1
uniprot id: A0A4X1TXP4
uniprot id: A0A8D1ZTM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

9823:PRKG1
gene id: 9823:PRKG1
uniprot id: A0A4X1V6L9
uniprot id: Q3YJM5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9823:CLN5
gene id: 9823:CLN5
uniprot id: A0A287BKL1
uniprot id: A0A4X1V966
names: Similarity
messages: Belongs to the CLN5 family.

9823:HYAL1
gene id: 9823:HYAL1
uniprot id: Q6RHW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Highly expressed in spleen, kidney, and lung.
messages: Lysosome
messages: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity).
messages: Secreted

9823:SLCO3A1
gene id: 9823:SLCO3A1
uniprot id: A0A287ASP2
uniprot id: A0A4X1UGL5
uniprot id: F1SCI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9823:ICAM3
gene id: 9823:ICAM3
uniprot id: C0JX97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9823:AOC2
gene id: 9823:AOC2
uniprot id: A0A480WBC5
uniprot id: A0A4X1TX67
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9823:DNMT3A
gene id: 9823:DNMT3A
uniprot id: A1XX82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9823:PPP2R2B
gene id: 9823:PPP2R2B
uniprot id: P54614
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: Brain.
messages: Cytoplasm
messages: Membrane
messages: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TOMM22 (By similarity). Interacts with IER5 (via N- and C-terminal regions) (By similarity).
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
messages: cytoskeleton

9823:ITIH2
gene id: 9823:ITIH2
uniprot id: O02668
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITIH family.
messages: Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
messages: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin.
messages: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Secreted

9823:ABHD1
gene id: 9823:ABHD1
uniprot id: A0A8D1B060
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9823:LOC100152013
gene id: 9823:LOC100152013
uniprot id: F1S3P9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:GSK3B
gene id: 9823:GSK3B
uniprot id: B2LUN4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9823:RPL8
gene id: 9823:RPL8
uniprot id: A0A4X1UQ84
uniprot id: F2Z567
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9823:LOC396866
gene id: 9823:LOC396866
uniprot id: Q28988
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Cytoplasm
messages: This is an intracellular thiol proteinase inhibitor.

9823:STIM1
gene id: 9823:STIM1
uniprot id: A0A287BE30
uniprot id: A0A480K0A2
uniprot id: A0A8D0W1L6
uniprot id: B4XH83
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:AHSA1
gene id: 9823:AHSA1
uniprot id: A0A4X1T4G7
uniprot id: A0A8D0I062
names: Similarity
messages: Belongs to the AHA1 family.

9823:UOX
gene id: 9823:UOX
uniprot id: P16164
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Homotetramer.
messages: Peroxisome

9823:SCAMP4
gene id: 9823:SCAMP4
uniprot id: A0A4X1VU89
uniprot id: F1SDH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9823:PRDX5
gene id: 9823:PRDX5
uniprot id: Q9GLW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Peroxisome matrix
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

9823:ZDHHC24
gene id: 9823:ZDHHC24
uniprot id: A0A480WG70
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:LOC100525165
gene id: 9823:LOC100525165
uniprot id: A0A4X1WBA8
uniprot id: A0A5G2QAN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:C1QA
gene id: 9823:C1QA
uniprot id: Q69DL0
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain. Interacts (via C-terminus) with CD33; this interaction activates CD33 inhibitory motifs.
messages: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
messages: O-linked glycans are Glc-Gal disaccharides typically found as secondary modifications of hydroxylated lysines in collagen-like domains.
messages: Proline residues in the collagen-like domain motif, GXPG, are typically 4-hydroxylated.
messages: Secreted

9823:PCSK1
gene id: 9823:PCSK1
uniprot id: Q28959
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9823:HINT2
gene id: 9823:HINT2
uniprot id: A0A4X1VTQ0
names: Similarity
messages: Belongs to the HINT family.

9823:PRPS1
gene id: 9823:PRPS1
uniprot id: A0A4X1W5D4
uniprot id: A0A8D1IY65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9823:CX3CR1
gene id: 9823:CX3CR1
uniprot id: A0A4X1TT40
uniprot id: I3LAU2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9823:CHAC2
gene id: 9823:CHAC2
uniprot id: A0A4X1WC75
uniprot id: A0A8D0YTN7
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9823:AMH
gene id: 9823:AMH
uniprot id: A0A4X1VNC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
messages: Secreted

9823:TET1
gene id: 9823:TET1
uniprot id: A0A4X1TN68
uniprot id: M9T6D7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9823:ID1
gene id: 9823:ID1
uniprot id: A0A8D1K6E8
uniprot id: B3W6M6
names: Subcellular Location Annotation
messages: Nucleus

9823:ATP5L
gene id: 9823:ATP5L
uniprot id: A0A4X1SQX6
uniprot id: A0A8D0JB11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9823:LOC100512888
gene id: 9823:LOC100512888
uniprot id: A0A480JTH2
uniprot id: A0A8D1FP05
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:POLR2I
gene id: 9823:POLR2I
uniprot id: A0A480LGI2
uniprot id: P60899
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).
messages: nucleolus

9823:DPM1
gene id: 9823:DPM1
uniprot id: A0A480VTP7
uniprot id: A0A8D1N733
uniprot id: A5GFZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Binds 1 divalent metal cation.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; within the complex, directly interacts with DPM3. This interaction may stabilize DPM1.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9823:UGT2B31
gene id: 9823:UGT2B31
uniprot id: I3LBU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9823:ATP5A1
gene id: 9823:ATP5A1
uniprot id: P80021
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated on lysine residues. BLOC1S1 is required for acetylation.
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Expressed in heart (at protein level).
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1) (PubMed:1714390). CF(0) has three main subunits: a, b and c (By similarity). Interacts with ATPAF2. Interacts with HRG; the interaction occurs on the surface of T-cells and alters the cell morphology when associated with concanavalin (in vitro). Interacts with PLG (angiostatin peptide); the interaction inhibits most of the angiogenic properties of angiostatin (By similarity). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with BLOC1S1 (By similarity). Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F(1)F(0) ATP synthase and enhances neurons metabolic efficiency (By similarity). Interacts with CLN5 and PPT1 (By similarity). Interacts with S100A1; this interaction increases F1-ATPase activity (By similarity). Interacts with ABCB7; this interaction allows the regulation of cellular iron homeostasis and cellular reactive oxygen species (ROS) levels in cardiomyocytes (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: The siderophore enterobactin (Ent) produced by enteric bacteria binds Fe(3+) and helps bacteria scavenge iron ions from the environment. As a consequence, the mammalian siderocalin LCN2 plays an important role in defense against bacterial infections by sequestering iron bound to microbial siderophores. LCN2 can also bind iron bound to endogenous or nutrient-derived iron chelators and plays an important role in cellular iron homeostasis. Enterobactin produced by non-pathogenic E.coli strains can facilitate mitochondrial iron assimilation, suggesting that iron bound to siderophores from non-pathogenic bacteria may contribute to iron absorption by the host.

9823:OPRK1
gene id: 9823:OPRK1
uniprot id: A0A4X1T6Q9
uniprot id: F1RSG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with NHERF1. Interacts with GABARAPL1.
messages: Membrane

9823:ARHGEF12
gene id: 9823:ARHGEF12
uniprot id: A0A4X1VLK8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9823:GRK3
gene id: 9823:GRK3
uniprot id: A0A480X2X7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9823:CRSP3
gene id: 9823:CRSP3
uniprot id: Q766Y6
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calcitonin family.
messages: Mainly expressed in the thyroid gland and CNS. Found in the nerve cells of cerebrum, hippocampus, hypothalamus, pons/midbrain and thalamus.
messages: Secreted

9823:LOC100624648
gene id: 9823:LOC100624648
uniprot id: A0A4X1TYS3
uniprot id: K7GP27
names: Similarity
messages: Belongs to the WD repeat EBI family.

9823:CDC42EP4
gene id: 9823:CDC42EP4
uniprot id: A0A4X1SKS7
uniprot id: F1RV35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9823:FGF18
gene id: 9823:FGF18
uniprot id: A0A4X1U5Q8
uniprot id: A0A5G2QUY7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:PCBD1
gene id: 9823:PCBD1
uniprot id: A0A4X1TCW0
uniprot id: F1SUB1
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9823:IL12A
gene id: 9823:IL12A
uniprot id: Q29053
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. This heterodimer is known as interleukin IL-12. Heterodimer with EBI3/IL27B; not disulfide-linked. This heterodimer is known as interleukin IL-35. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
messages: Secreted

9823:PLP1
gene id: 9823:PLP1
uniprot id: Q712P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Cell membrane
messages: Myelin membrane
messages: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin (By similarity).

9823:AKR1CL1
gene id: 9823:AKR1CL1
uniprot id: Q2TJA5
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9823:PEBP1
gene id: 9823:PEBP1
uniprot id: A0A4X1TTH9
uniprot id: A0A8D1IYQ4
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9823:GNB3
gene id: 9823:GNB3
uniprot id: A0A8D1V493
uniprot id: F1SLU8
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9823:LOC100517331
gene id: 9823:LOC100517331
uniprot id: F1S6M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:COQ4
gene id: 9823:COQ4
uniprot id: A0A8D1SBE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

9823:NIPAL1
gene id: 9823:NIPAL1
uniprot id: A0A287AD64
uniprot id: A0A4X1UI07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9823:TRMT6
gene id: 9823:TRMT6
uniprot id: A0A480WZS9
uniprot id: A0A8D1B7S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9823:MYC
gene id: 9823:MYC
uniprot id: Q29031
names: Biotechnology
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Alternative translation initiation from an upstream, in-frame non-ATG (CTG) codon or a downstream ATG start site results in the production of 2 isoforms with distinct N-termini, shown in this entry as isoform 2 and isoform 1, respectively.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-71 and Ser-75) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity). Interacts with CIP2A; leading to the stabilization of MYC (By similarity).
messages: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
messages: Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser-342 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-75 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-75 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-71. Phosphorylation at Thr-71 and Ser-75 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at Ser-75 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity).
messages: Produced by alternative translation initiation from a CTG codon, which is translated as Met.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).
messages: Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-71 and Ser-75, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner.
messages: nucleolus
messages: nucleoplasm

9823:NEUROD4
gene id: 9823:NEUROD4
uniprot id: A0A8D0QLE1
uniprot id: A0A8D1FBA3
names: Subcellular Location Annotation
messages: Nucleus

9823:SERINC2
gene id: 9823:SERINC2
uniprot id: A0A480TQ97
uniprot id: A0A8D1VLG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9823:GALNT14
gene id: 9823:GALNT14
uniprot id: A0A4X1TER4
uniprot id: F1S3Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9823:HDC
gene id: 9823:HDC
uniprot id: A0A8D1HD29
uniprot id: F1SQH5
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9823:WDR46
gene id: 9823:WDR46
uniprot id: A0A287BMA8
names: Subcellular Location Annotation
messages: nucleolus

9823:RBM42
gene id: 9823:RBM42
uniprot id: A0A4X1TII9
uniprot id: A0A8D0N039
uniprot id: A0A8D1C3E8
uniprot id: A0A8D1WAD4
names: Similarity
messages: Belongs to the RRM RBM42 family.

9823:TM2D3
gene id: 9823:TM2D3
uniprot id: A0A4X1U956
uniprot id: A0A8D0KD82
uniprot id: A0A8D0KDB0
uniprot id: F1RZ95
names: Subcellular Location Annotation
messages: Membrane

9823:CORO2A
gene id: 9823:CORO2A
uniprot id: A0A4X1TZM0
uniprot id: A0A8D1W194
names: Similarity
messages: Belongs to the WD repeat coronin family.

9823:NIP7
gene id: 9823:NIP7
uniprot id: Q56P27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NIP7 family.
messages: Expressed in muscle, heart, liver, fat, kidney and lung. Weakly expressed in small intestine, ovary and spleen.
messages: Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. Interacts with FTSJ3 (By similarity).
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

9823:SPTSSA
gene id: 9823:SPTSSA
uniprot id: A0A4X1T7F5
uniprot id: A0A8W4FE73
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:NKRF
gene id: 9823:NKRF
uniprot id: A0A8D1L7Q1
uniprot id: F1RUA0
names: Similarity
messages: Belongs to the CARF family.

9823:LOC100153329
gene id: 9823:LOC100153329
uniprot id: A0A8D0PDZ6
uniprot id: A0A8D1GQW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:CEND1
gene id: 9823:CEND1
uniprot id: Q29026
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Appears during early brain development where it increases with age to give high levels in the mature animal.
messages: Belongs to the CEND1 family.
messages: Cell membrane
messages: Endomembrane system
messages: Found in the spinal cord, cerebellum and cerebrum, where it is localized in neurons.
messages: Homodimer (By similarity). Interacts with AHI1 (By similarity).
messages: Involved in neuronal differentiation.

9823:CERS4
gene id: 9823:CERS4
uniprot id: A0A8D0J161
uniprot id: D0G774
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9823:NAF1
gene id: 9823:NAF1
uniprot id: A0A5G2QM69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

9823:MOS
gene id: 9823:MOS
uniprot id: P50118
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Restricted to gonadal tissues.

9823:FAM229B
gene id: 9823:FAM229B
uniprot id: A0A286ZZE4
uniprot id: A0A8D1REW2
names: Similarity
messages: Belongs to the FAM229 family.

9823:BID
gene id: 9823:BID
uniprot id: Q4JHS0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2. Interacts with PLEKHN1.
messages: Induces caspase activation and apoptosis (By similarity). Allows the release of cytochrome c (By similarity).
messages: Induces caspases and apoptosis. Counters the protective effect of BCL2.
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
messages: Interacts with ITCH (By similarity). Interacts with MTCH2 (By similarity).
messages: Mitochondrion membrane
messages: Mitochondrion outer membrane
messages: TNF-alpha induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products (By similarity). Cleaved by CASP6 into a major p15 and minor p13 products, leading to release of cytochrome c and subsequent nonalcoholic steatohepatitis (By similarity).
messages: Ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.

9823:HNRNPA2B1
gene id: 9823:HNRNPA2B1
uniprot id: A0A4X1TY93
uniprot id: A0A8D1MKR9
names: Subcellular Location Annotation
messages: Cytoplasmic granule

9823:SLA-DOA
gene id: 9823:SLA-DOA
uniprot id: A0A8D1ZXG7
uniprot id: A5D9K5
names: Similarity
messages: Belongs to the MHC class II family.

9823:KIAA2022
gene id: 9823:KIAA2022
uniprot id: A0A4X1W3A1
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100521430
gene id: 9823:LOC100521430
uniprot id: A0A4X1UKF1
uniprot id: A0A5G2RD84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GALNT15
gene id: 9823:GALNT15
uniprot id: A0A4X1UQ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9823:LOC100512477
gene id: 9823:LOC100512477
uniprot id: A0A4X1SLT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RTN4
gene id: 9823:RTN4
uniprot id: A0A287B5Q4
uniprot id: A0A4X1WDD7
uniprot id: A0A8D1EXL5
uniprot id: A0A8D1MN63
uniprot id: A0A8W4FPP8
uniprot id: Q6IM70
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:IER2
gene id: 9823:IER2
uniprot id: A0A4X1T0S1
uniprot id: A0A8W4FC27
names: Similarity
messages: Belongs to the IER family.

9823:RPL27
gene id: 9823:RPL27
uniprot id: A0A480JJD1
uniprot id: A1XQU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Component of the large ribosomal subunit (PubMed:24930395). Interacts with RRP1B (By similarity). Component of the large ribosomal subunit. Interacts with RRP1B. Interacts with DHX33 (By similarity).
messages: Component of the large ribosomal subunit (PubMed:24930395). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

9823:NCAPG
gene id: 9823:NCAPG
uniprot id: A0A480VBP6
uniprot id: A0A4X1VBG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9823:TRIT1
gene id: 9823:TRIT1
uniprot id: A0A480EF58
uniprot id: A0A8D1IVU4
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

9823:VPS36
gene id: 9823:VPS36
uniprot id: A0A286ZW46
uniprot id: A0A4X1SQ57
uniprot id: A0A8D1DW19
uniprot id: A0A8D1DY89
uniprot id: A0A8D1UMB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

9823:CCNI
gene id: 9823:CCNI
uniprot id: A0A8D0R2W9
uniprot id: F1RYS4
names: Similarity
messages: Belongs to the cyclin family.

9823:ING3
gene id: 9823:ING3
uniprot id: A0A4X1W373
uniprot id: A0A8D0PV35
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9823:CD53
gene id: 9823:CD53
uniprot id: A0A4X1TCS7
uniprot id: F1S628
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:GOLT1B
gene id: 9823:GOLT1B
uniprot id: A0A8D0Z1K2
uniprot id: A0A8D1PDZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9823:MPP1
gene id: 9823:MPP1
uniprot id: A0A4X1T7B8
uniprot id: K7GP41
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

9823:LAPTM4A
gene id: 9823:LAPTM4A
uniprot id: A0A4X1U6W0
uniprot id: I3LPB3
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9823:CARNMT1
gene id: 9823:CARNMT1
uniprot id: A0A480EE99
uniprot id: A0A8D2A6D9
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

9823:FAM213B
gene id: 9823:FAM213B
uniprot id: A9CQL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. Prostamide/prostaglandin F synthase subfamily.
messages: Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha).
messages: cytosol

9823:FGF11
gene id: 9823:FGF11
uniprot id: A0A287BK28
uniprot id: A0A4X1V2Z2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:CPEB2
gene id: 9823:CPEB2
uniprot id: A0A8D0X731
uniprot id: D7R612
names: Similarity
messages: Belongs to the RRM CPEB family.

9823:IFN-DELTA-7
gene id: 9823:IFN-DELTA-7
uniprot id: A0A4X1W6K1
uniprot id: C8CKB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:LOC100520398
gene id: 9823:LOC100520398
uniprot id: A0A8W4FKU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MAP3K8
gene id: 9823:MAP3K8
uniprot id: A0A4X1UIT6
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9823:PORCN
gene id: 9823:PORCN
uniprot id: A0A287A5T7
uniprot id: A0A287B2I9
uniprot id: A0A4X1VEY2
uniprot id: A0A4X1VKA3
uniprot id: A0A4X1VLP4
uniprot id: A0A8D1P6V5
uniprot id: I3LFC9
uniprot id: I3LRY6
names: Subcellular Location Annotation
messages: Membrane

9823:TFAP2C
gene id: 9823:TFAP2C
uniprot id: A0A8D1DB58
uniprot id: A5GFZ9
names: Similarity
messages: Belongs to the AP-2 family.

9823:PPP1R16B
gene id: 9823:PPP1R16B
uniprot id: A0A8D1WB37
uniprot id: F1SDW9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:OXSR1
gene id: 9823:OXSR1
uniprot id: A0A096ZXA2
uniprot id: Q863I2
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated following phosphorylation by WNK kinases (WNK1, WNK2, WNK3 or WNK4).
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (By similarity). Specifically recognizes and binds proteins with a RFXV motif (By similarity). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (By similarity). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (By similarity). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (By similarity). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (By similarity). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (By similarity). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (By similarity). Phosphorylates RELL1, RELL2, RELT and PAK1. Phosphorylates PLSCR1 in the presence of RELT (By similarity).
messages: Phosphorylation at Thr-185 by WNK kinases (WNK1, WNK2, WNK3 or WNK4) is required for activation. Autophosphorylated; promoting its activity.

9823:PABPC1
gene id: 9823:PABPC1
uniprot id: A0A4X1TSV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9823:AKT3
gene id: 9823:AKT3
uniprot id: A0A4X1T4H6
uniprot id: A0A4X1T4I6
uniprot id: A0A4X1T5U2
uniprot id: A0A8D0S186
uniprot id: A0A8D0X2I7
uniprot id: A0A8D1DCQ6
uniprot id: G9BWQ3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9823:NCF2
gene id: 9823:NCF2
uniprot id: A0A480TE35
uniprot id: A0A8D0JVZ4
uniprot id: B1PK10
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9823:FAM20B
gene id: 9823:FAM20B
uniprot id: A0A8D0JM33
uniprot id: F1S6Y3
names: Similarity
messages: Belongs to the FAM20 family.

9823:LOC100622387
gene id: 9823:LOC100622387
uniprot id: A0A8D1QBH6
uniprot id: F2Z587
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:LOC110255251
gene id: 9823:LOC110255251
uniprot id: A0A5G2QXL9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:EIF2S2
gene id: 9823:EIF2S2
uniprot id: A0A4X1T4S6
uniprot id: A0A8D0HZZ9
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9823:C16H5orf22
gene id: 9823:C16H5orf22
uniprot id: A0A480Y8G2
uniprot id: A0A4X1TIX6
names: Similarity
messages: Belongs to the UPF0489 family.

9823:CDC37L1
gene id: 9823:CDC37L1
uniprot id: A0A8D0XBG9
uniprot id: F1SK44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9823:PTGDR
gene id: 9823:PTGDR
uniprot id: A0A4X1WD75
uniprot id: F1SFF2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:MAN2B1
gene id: 9823:MAN2B1
uniprot id: K9J4R3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9823:MIF
gene id: 9823:MIF
uniprot id: P80928
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIF family.
messages: Cytoplasm
messages: Homotrimer (By similarity). Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, USO1, COPS5 and BNIPL (By similarity).
messages: Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
messages: Secreted

9823:CACNG3
gene id: 9823:CACNG3
uniprot id: A0A287AXU2
uniprot id: A0A8D1A9M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9823:RPL13A
gene id: 9823:RPL13A
uniprot id: A0A4X1VYE4
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9823:LOC100736818
gene id: 9823:LOC100736818
uniprot id: A0A4X1TMP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9823:SLA-2
gene id: 9823:SLA-2
uniprot id: Q4AC39
names: Similarity
messages: Belongs to the MHC class I family.

9823:SLC16A5
gene id: 9823:SLC16A5
uniprot id: A0A287AB15
uniprot id: A0A4X1V462
uniprot id: K9J6H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9823:MPC2
gene id: 9823:MPC2
uniprot id: A0A4X1V8M2
uniprot id: A0A8D0ING5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9823:THOC6
gene id: 9823:THOC6
uniprot id: A0A286ZII9
uniprot id: A0A8D0HP96
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9823:IFNE
gene id: 9823:IFNE
uniprot id: A7UHZ5
uniprot id: C8CKC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted
messages: Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).

9823:ALDH6A1
gene id: 9823:ALDH6A1
uniprot id: A0A8D1DYX8
uniprot id: F1S3H1
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9823:TMX2
gene id: 9823:TMX2
uniprot id: A0A8D0I5I8
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9823:HAGHL
gene id: 9823:HAGHL
uniprot id: A0A481DA93
uniprot id: A0A8D1QI56
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9823:POLR3GL
gene id: 9823:POLR3GL
uniprot id: A0A4X1SJZ4
uniprot id: A0A8D0NKQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9823:TCTN1
gene id: 9823:TCTN1
uniprot id: A0A480JQD0
uniprot id: A0A4X1U4H6
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9823:CASP6
gene id: 9823:CASP6
uniprot id: A0A4X1UXQ4
uniprot id: A0A8D0K1M4
uniprot id: A0A8D0QWP5
uniprot id: F1S131
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:MRPL50
gene id: 9823:MRPL50
uniprot id: A0A8D0XGN5
uniprot id: A0A8D1EHA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9823:UBAP2L
gene id: 9823:UBAP2L
uniprot id: A0A4X1W143
uniprot id: A0A5G2QD79
uniprot id: A0A8D0RB60
uniprot id: A0A8D0Y067
uniprot id: A0A8D1BS26
uniprot id: A0A8D1W5B3
uniprot id: A0A8D1W5Y5
uniprot id: I3LQ83
names: Subcellular Location Annotation
messages: Cytoplasm

9823:COQ10A
gene id: 9823:COQ10A
uniprot id: A0A8D1P408
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9823:UBA6
gene id: 9823:UBA6
uniprot id: A0A480TN91
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9823:LOC100523452
gene id: 9823:LOC100523452
uniprot id: A0A4X1TJ43
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FAM26D
gene id: 9823:FAM26D
uniprot id: A0A4X1V2M0
uniprot id: A0A8D1M6Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9823:TEKT1
gene id: 9823:TEKT1
uniprot id: A0A8D1EF23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9823:HSPA8
gene id: 9823:HSPA8
uniprot id: A0A480ECX1
uniprot id: A0A4X1VJ17
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9823:IDH3G
gene id: 9823:IDH3G
uniprot id: A0A480K0P7
uniprot id: A0A8D1PNK1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9823:TMED4
gene id: 9823:TMED4
uniprot id: A0A8D1PZN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:OOEP
gene id: 9823:OOEP
uniprot id: A0A8D1BR25
uniprot id: E2IUK8
names: Similarity
messages: Belongs to the KHDC1 family.

9823:RSAD1
gene id: 9823:RSAD1
uniprot id: A0A8D1PHX3
uniprot id: F1RT95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Mitochondrion

9823:NDUFB2
gene id: 9823:NDUFB2
uniprot id: A0A4X1V766
uniprot id: A0A8D1G9F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:CDKN1B
gene id: 9823:CDKN1B
uniprot id: A0A4X1V4V1
uniprot id: Q9BDC3
names: Similarity
messages: Belongs to the CDI family.

9823:KRT34
gene id: 9823:KRT34
uniprot id: A0A4X1U891
uniprot id: F1S0K4
names: Similarity
messages: Belongs to the intermediate filament family.

9823:PTOV1
gene id: 9823:PTOV1
uniprot id: A0A8D1QET8
uniprot id: F1RHU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
messages: Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: May interact with CREBBP. Interacts with FLOT1.
messages: Nucleus
messages: perinuclear region

9823:TM6SF1
gene id: 9823:TM6SF1
uniprot id: A0A287BAJ7
uniprot id: A0A4X1ULT7
uniprot id: A0A4X1UP10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

9823:SLC25A44
gene id: 9823:SLC25A44
uniprot id: A0A4X1VZF2
uniprot id: A0A8D0U889
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:ZNF706
gene id: 9823:ZNF706
uniprot id: A0A4X1TUR5
uniprot id: A0A8W4FLV5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:FAU
gene id: 9823:FAU
uniprot id: P55812
names: Miscellaneous
names: Similarity
messages: Belongs to the ubiquitin family.
messages: This protein is synthesized with ribosomal S30 as its C-terminal extension.

9823:RPL31
gene id: 9823:RPL31
uniprot id: P62901
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9823:TMPRSS15
gene id: 9823:TMPRSS15
uniprot id: P98074
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Heterotrimer of a catalytic (light) chain, a multidomain (heavy) chain, and a mini chain.
messages: Membrane
messages: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
messages: The chains are derived from a single precursor that is cleaved by a trypsin-like protease.
messages: The mini chain may be cleaved by elastase.

9823:LOC100739286
gene id: 9823:LOC100739286
uniprot id: A0A4X1TW59
uniprot id: A0A8D1KG45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CEP76
gene id: 9823:CEP76
uniprot id: A0A480QQC8
uniprot id: A0A4X1VTN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP76 family.
messages: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
messages: centriole

9823:EMG1
gene id: 9823:EMG1
uniprot id: A0A4X1UWG9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9823:KCNG1
gene id: 9823:KCNG1
uniprot id: A0A8D1ICQ0
uniprot id: A5GFZ3
names: Subcellular Location Annotation
messages: Membrane

9823:CAMTA2
gene id: 9823:CAMTA2
uniprot id: A0A287BG15
uniprot id: A0A287BRF2
uniprot id: A0A8D0UJU3
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

9823:NMU
gene id: 9823:NMU
uniprot id: A0A287BA96
uniprot id: A0A8D0ZJ63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9823:STRIP2
gene id: 9823:STRIP2
uniprot id: A0A287BNU2
uniprot id: A0A4X1VZZ4
names: Similarity
messages: Belongs to the STRIP family.

9823:VKORC1L1
gene id: 9823:VKORC1L1
uniprot id: A0A4X1SYC2
uniprot id: A0A5K1VIT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:MED19
gene id: 9823:MED19
uniprot id: A0A480E1V8
uniprot id: A0A8D1L1F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:LOC100521433
gene id: 9823:LOC100521433
uniprot id: A0A4X1U0G5
uniprot id: A0A5G2R1Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:VPS41
gene id: 9823:VPS41
uniprot id: A0A4X1UMY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

9823:IL26
gene id: 9823:IL26
uniprot id: A0A287BFZ9
uniprot id: A0A4X1W3X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9823:SLC30A5
gene id: 9823:SLC30A5
uniprot id: B6ECZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9823:QDPR
gene id: 9823:QDPR
uniprot id: Q8MJ30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
messages: Homodimer.

9823:STRN4
gene id: 9823:STRN4
uniprot id: A0A4X1VW91
uniprot id: F1RM09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9823:ZNF174
gene id: 9823:ZNF174
uniprot id: A0A4X1VNH3
uniprot id: A0A8D1IBE1
names: Subcellular Location Annotation
messages: Nucleus

9823:CHST13
gene id: 9823:CHST13
uniprot id: A0A480TFC8
uniprot id: A0A4X1TRW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:SMARCA4
gene id: 9823:SMARCA4
uniprot id: A0A480YYJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9823:F5
gene id: 9823:F5
uniprot id: Q9GLP1
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin.
messages: Domain B contains 41 X 9 AA tandem repeats. Domains C1 and C2 may be involved in membrane binding.
messages: Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent. Forms heterodimer with SERPINA5 (By similarity).
messages: Inhibited by SERPINA5.
messages: Secreted
messages: Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).

9823:OLF42-1
gene id: 9823:OLF42-1
uniprot id: I7GH08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:AR
gene id: 9823:AR
uniprot id: A0A4X1VUS1
uniprot id: F1RTM6
uniprot id: Q9GKL7
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1 and RREB1. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts with MACROD1 (via macro domain) (By similarity). Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with HIP1 (via coiled coil domain). Interacts (via ligand-binding domain) with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with RACK1. Interacts with RANBP10; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone-independent way; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK and NCOA3. Interacts with CRY1. Interacts with CCAR1 and GATA2. Interacts with ZNF318. Interacts with BUD31. Interacts with ARID4A. Interacts with ARID4B. Interacts (via NR LBD domain) with ZBTB7A; the interaction is direct and androgen-dependent (By similarity). Interacts with NCOR1 (By similarity). Interacts with NCOR2 (By similarity). Interacts with CRY2 in a ligand-dependent manner (By similarity).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N-terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain (By similarity).
messages: Cytoplasm
messages: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
messages: Nucleus
messages: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity).
messages: Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-511 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression (By similarity). Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity. Phosphorylation at Ser-65 by CDK9 regulates AR promoter selectivity and cell growth (By similarity).
messages: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
messages: Sumoylated on Lys-378 (major) and Lys-497 (By similarity). Ubiquitinated. Deubiquitinated by USP26 (By similarity). 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity (By similarity).
messages: Transcriptional activity is enhanced by binding to RANBP9.

9823:MBP
gene id: 9823:MBP
uniprot id: Q6J2R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin basic protein family.
messages: Myelin membrane

9823:CAMK2D
gene id: 9823:CAMK2D
uniprot id: Q95266
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity (By similarity).
messages: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state (By similarity).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with RRAD CACNB2 (By similarity).
messages: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimu…
messages: Sarcoplasmic reticulum membrane
messages: The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
messages: sarcolemma

9823:LOC100522011
gene id: 9823:LOC100522011
uniprot id: A0A4X1TCM8
uniprot id: K7GQI7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

9823:MBOAT7
gene id: 9823:MBOAT7
uniprot id: A0A4X1VJN0
uniprot id: F1RNH0
names: Subcellular Location Annotation
messages: Membrane

9823:SRSF2
gene id: 9823:SRSF2
uniprot id: Q06A98
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6, which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation (By similarity).
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation (By similarity).
messages: In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with CCNL1 and CCNL2. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus). Interacts with BRDT (By similarity).
messages: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: nucleoplasm

9823:SNX11
gene id: 9823:SNX11
uniprot id: A0A8D0JA93
uniprot id: A0A8D1PM87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9823:DPM3
gene id: 9823:DPM3
uniprot id: A0A4X1VV08
uniprot id: A0A8W4FL18
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

9823:TPK1
gene id: 9823:TPK1
uniprot id: A0A4X1UMM2
uniprot id: A0A8D0K5F4
uniprot id: A0A8D1F7G3
uniprot id: F1SAD1
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9823:FAM206A
gene id: 9823:FAM206A
uniprot id: A0A8D1I7N9
uniprot id: F1SP28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9823:LOC100524254
gene id: 9823:LOC100524254
uniprot id: A0A8D0ZJL5
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9823:NAA40
gene id: 9823:NAA40
uniprot id: A0A8D0ZH34
uniprot id: F1RPY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

9823:GKN3
gene id: 9823:GKN3
uniprot id: D2XPP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrokine family.
messages: May inhibit gastric epithelial cell proliferation.
messages: Secreted

9823:MANBA
gene id: 9823:MANBA
uniprot id: A0A8D0KDM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

9823:PPP1R14C
gene id: 9823:PPP1R14C
uniprot id: A0A4X1VL95
uniprot id: A0A5G2RL03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Inhibitor of PPP1CA.
messages: Membrane

9823:SFTPA1
gene id: 9823:SFTPA1
uniprot id: P49874
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFTPA family.
messages: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.
messages: Oligomeric complex of 6 set of homotrimers.
messages: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
messages: Secreted
messages: extracellular matrix
messages: surface film

9823:MFAP1
gene id: 9823:MFAP1
uniprot id: A0A4X1VC88
uniprot id: A0A8D0T9V6
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9823:FRK
gene id: 9823:FRK
uniprot id: A0A4X1V6L0
uniprot id: F1RZK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:NPL
gene id: 9823:NPL
uniprot id: A0A481AUE8
uniprot id: Q9BEC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
messages: Cytoplasm
messages: Homotetramer.

9823:LOC100516426
gene id: 9823:LOC100516426
uniprot id: A0A286ZP59
uniprot id: A0A4X1U0H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SPTSSB
gene id: 9823:SPTSSB
uniprot id: A0A5G2RLJ3
uniprot id: A0A8D1MU24
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LOC106505477
gene id: 9823:LOC106505477
uniprot id: A0A5G2QIQ5
uniprot id: A0A8D1CSU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GGTA1P
gene id: 9823:GGTA1P
uniprot id: A0A4X1UM53
uniprot id: A0A8D1XAT9
uniprot id: P50127
uniprot id: Q548W5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Golgi stack membrane
messages: Membrane
messages: Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isogloboside 3 (iGb3) (By similarity).
messages: The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.

9823:NEDD9
gene id: 9823:NEDD9
uniprot id: A0A287A380
uniprot id: A0A4X1SFI6
uniprot id: A0A4X1SGA7
uniprot id: F1RV86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9823:CRX
gene id: 9823:CRX
uniprot id: A0A4X1W2N1
names: Subcellular Location Annotation
messages: Nucleus

9823:NXPH3
gene id: 9823:NXPH3
uniprot id: A0A4X1UM08
uniprot id: F1RTC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9823:TSPAN33
gene id: 9823:TSPAN33
uniprot id: A0A4X1W1D2
uniprot id: A0A8D2CBR4
uniprot id: F1SMQ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:BRMS1L
gene id: 9823:BRMS1L
uniprot id: A0A4X1TCZ2
uniprot id: A0A8D1UDN1
names: Subcellular Location Annotation
messages: Nucleus

9823:PITPNM2
gene id: 9823:PITPNM2
uniprot id: A0A480THL1
uniprot id: A0A8D1JJ47
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9823:RBPJ
gene id: 9823:RBPJ
uniprot id: A0A287A324
uniprot id: A0A4X1V8S0
uniprot id: A0A4X1V9N0
uniprot id: A0A4X1VAZ3
uniprot id: A0A8D0HYD2
uniprot id: A0A8D1KDI8
uniprot id: A0A8D1M2Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9823:VCL
gene id: 9823:VCL
uniprot id: A0A4X1SRF3
uniprot id: A0A8D0PFK1
uniprot id: P26234
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated; mainly by myristic acid but also by a small amount of palmitic acid.
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Exhibits self-association properties. Part of a complex composed of THSD1, PTK2/FAK1, TLN1 and VCL (By similarity). Interacts with APBB1IP, NRAP and TLN1. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin (By similarity). Interacts with SORBS1 (By similarity). Interacts with SYNM (By similarity). Interacts with CTNNA1 (By similarity). Binds to ACTN4; this interaction triggers conformational changes (By similarity).
messages: Exists in at least two conformations. When in the closed, 'inactive' conformation, extensive interactions between the head and tail domains prevent detectable binding to most of its ligands. It takes on an 'active' conformation after cooperative and simultaneous binding of two different ligands. This activation involves displacement of the head-tail interactions and leads to a significant accumulation of ternary complexes. The active form then binds a number of proteins that have both signaling and structural roles that are essential for cell adhesion.
messages: Membrane
messages: Phosphorylated; on serines, threonines and tyrosines. Phosphorylation on Tyr-1134 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques (By similarity).
messages: The N-terminal globular head (Vh) comprises of subdomains D1-D4. The C-terminal tail (Vt) binds F-actin and cross-links actin filaments into bundles. An intramolecular interaction between Vh and Vt masks the F-actin-binding domain located in Vt. The binding of talin and alpha-actinin to the D1 subdomain of vinculin induces a helical bundle conversion of this subdomain, leading to the disruption of the intramolecular interaction and the exposure of the cryptic F-actin-binding domain of Vt. Vt inhibits actin filament barbed end elongation without affecting the critical concentration of actin assembly.
messages: adherens junction
messages: cytoskeleton
messages: focal adhesion
messages: podosome
messages: sarcolemma

9823:SART1
gene id: 9823:SART1
uniprot id: A0A8D1XQ20
uniprot id: F1RU31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

9823:LIAS
gene id: 9823:LIAS
uniprot id: A0A480R659
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9823:CNNM1
gene id: 9823:CNNM1
uniprot id: A0A4X1U6W3
uniprot id: F1S8W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9823:GFRA3
gene id: 9823:GFRA3
uniprot id: A0A480PSU1
names: Similarity
messages: Belongs to the GDNFR family.

9823:TARBP2
gene id: 9823:TARBP2
uniprot id: A0A287BSF9
uniprot id: A0A4X1WAY9
uniprot id: A0A8D0LIU3
uniprot id: A0A8D0S1W2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9823:NFIB
gene id: 9823:NFIB
uniprot id: A0A286ZNP3
uniprot id: A0A4X1WAI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9823:GCNT7
gene id: 9823:GCNT7
uniprot id: A5GFW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 14 family.
messages: Glycosyltransferase.
messages: Golgi apparatus membrane

9823:LOC100624389
gene id: 9823:LOC100624389
uniprot id: A0A8D1BQ86
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:HSPB8
gene id: 9823:HSPB8
uniprot id: A0A4X1TV19
uniprot id: A0A8D0LH48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9823:PLK2
gene id: 9823:PLK2
uniprot id: A0A8D0PK30
uniprot id: F1SLJ2
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9823:ARPC5L
gene id: 9823:ARPC5L
uniprot id: B5APV1
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9823:MAOB
gene id: 9823:MAOB
uniprot id: A0A4X1VJA2
uniprot id: Q6PLK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

9823:LOC100516632
gene id: 9823:LOC100516632
uniprot id: A0A8D1LNZ3
uniprot id: I3LLI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SPIN2B
gene id: 9823:SPIN2B
uniprot id: A0A286ZXD6
uniprot id: A0A4X1VL59
uniprot id: A0A8D1B164
names: Similarity
messages: Belongs to the SPIN/STSY family.

9823:GALNT11
gene id: 9823:GALNT11
uniprot id: A0A287B5N4
uniprot id: A0A4X1UHW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9823:PRAF2
gene id: 9823:PRAF2
uniprot id: A0A4X1T6F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9823:OLFM4
gene id: 9823:OLFM4
uniprot id: A0A8D1XEM5
uniprot id: F1RJ68
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:BET1L
gene id: 9823:BET1L
uniprot id: A0A8D0LFA3
uniprot id: F1RGD1
names: Subcellular Location Annotation
messages: Membrane

9823:KCTD10
gene id: 9823:KCTD10
uniprot id: A0A480KXU6
names: Similarity
messages: Belongs to the BACURD family.

9823:HR
gene id: 9823:HR
uniprot id: A3RGC0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9823:NEK7
gene id: 9823:NEK7
uniprot id: A0A4X1SPB7
uniprot id: A0A4X1SPG3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:LOC100519205
gene id: 9823:LOC100519205
uniprot id: A0A8D0SIF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ACSM5
gene id: 9823:ACSM5
uniprot id: A0A8D2A1H2
uniprot id: I3L882
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:ACAT2
gene id: 9823:ACAT2
uniprot id: A0A287AHQ0
uniprot id: A0A4X1VWU7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9823:BEST3
gene id: 9823:BEST3
uniprot id: A0A480EBW3
uniprot id: A0A8D0UBG6
uniprot id: A0A8D1GVJ2
uniprot id: A0A8D1N044
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:LOC110255211
gene id: 9823:LOC110255211
uniprot id: A0A4X1ST70
uniprot id: A0A4X1TVA6
uniprot id: A0A4X1UEK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9823:TMEM167A
gene id: 9823:TMEM167A
uniprot id: A0A4X1T901
uniprot id: A0A8W4FGN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

9823:TM7SF3
gene id: 9823:TM7SF3
uniprot id: A0A4X1SIF4
uniprot id: A0A8D0LJ51
names: Subcellular Location Annotation
messages: Membrane

9823:CKS1B
gene id: 9823:CKS1B
uniprot id: A0A480C3W8
uniprot id: A0A4X1W0Z6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9823:TMEM55A
gene id: 9823:TMEM55A
uniprot id: A0A4X1UBV2
uniprot id: F1RXF6
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9823:CEBPE
gene id: 9823:CEBPE
uniprot id: A0A8D1TGA5
uniprot id: F1S9D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9823:SMN1
gene id: 9823:SMN1
uniprot id: A0A287B5F8
uniprot id: A0A480K549
uniprot id: A0A8D0ZU32
uniprot id: A0A8D0ZV49
uniprot id: B3VQJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body
messages: Perikaryon
messages: Z line
messages: gem
messages: neuron projection

9823:RIDA
gene id: 9823:RIDA
uniprot id: A0A286ZNH3
uniprot id: A0A8D0NPR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9823:CYP2D25
gene id: 9823:CYP2D25
uniprot id: O46658
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the 25-hydroxylation of vitamin D(3) (calciol), 1alpha-hydroxyvitamin D(3) (alphacalcidiol) and some C27 steroids. In addition the enzyme catalyzes the hydroxylation of positions 11 and 12 of dodecanoate.
messages: Endoplasmic reticulum membrane
messages: Found in liver and kidney.
messages: Microsome membrane

9823:LOC106507488
gene id: 9823:LOC106507488
uniprot id: F1SQE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PDE4B
gene id: 9823:PDE4B
uniprot id: B3TNN3
uniprot id: B3TNN4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9823:GALE
gene id: 9823:GALE
uniprot id: A0A4X1VTU2
uniprot id: A0A8D0J228
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9823:BVES
gene id: 9823:BVES
uniprot id: B8Q0B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the popeye family.
messages: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Important for skeletal muscle and heart development. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury (By similarity).
messages: Homodimer. Homodimerization requires the C-terminus cytoplasmic region. Interacts (via the C-terminus cytoplasmic tail) with TJP1. Interacts (via the C-terminus cytoplasmic tail) with ARHGEF25/GEFT (via the DH domain). Interacts (via the C-terminus cytoplasmic tail) with VAMP3 (By similarity). Interacts with KCNK2; the interaction enhances KCNK2 surface expression (By similarity). Interacts with CAV3 (By similarity).
messages: Lateral cell membrane
messages: Membrane
messages: caveola
messages: sarcolemma
messages: tight junction

9823:NR2C2
gene id: 9823:NR2C2
uniprot id: A0A4X1U9D4
uniprot id: A0A4X1UBA4
uniprot id: A0A8D0LT51
uniprot id: A0A8D0WYU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:DOLPP1
gene id: 9823:DOLPP1
uniprot id: A0A287BKI5
uniprot id: A0A4X1TJ37
uniprot id: A0A4X1TLI0
uniprot id: A0A5G2QW58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9823:VARS
gene id: 9823:VARS
uniprot id: A0A8D1SAD4
uniprot id: B9TSR5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9823:FAM98C
gene id: 9823:FAM98C
uniprot id: A0A4X1T6N2
uniprot id: F1RI46
names: Similarity
messages: Belongs to the FAM98 family.

9823:NCOA1
gene id: 9823:NCOA1
uniprot id: Q4PJW2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors.
messages: Interacts with PPARA; the interaction is direct (By similarity). Interacts with PPARG; the interaction is direct (By similarity). Interacts with ESRRG; the interaction is direct (By similarity). Interacts with STAT5A (via FDL motif) (By similarity). Interacts with STAT5B (via FDL motif) (By similarity). Interacts with STAT6 (via LXXLL motif) (By similarity). Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif) (By similarity). Interacts with ASXL1 (By similarity). Interacts with the methyltransferase CARM1 (By similarity). Interacts with COPS5 (By similarity). Interacts with the histone acetyltransferase CREBBP (By similarity). Interacts with DDX5 (By similarity). Interacts with the histone acetyltransferase EP300 (By similarity). Interacts with ESR1 (By similarity). Interacts with GCCR (By similarity). Interacts with the basal transcription factor GTF2B (By similarity). Interacts with NCOA6 (By similarity). Interacts with NCOA2 (By similarity). Interacts with NR3C1 (By similarity). Interacts with NR4A1/Nur77 (By similarity). Interacts with NR4A3 (By similarity). Interacts with PCAF (By similarity). Interacts with PGR (By similarity). Interacts with PRMT2 (By similarity). Interacts with PRMT6 (By similarity). Interacts with PSMB9 (By similarity). Interacts with RXRA, the interaction is ligand-dependent (By similarity). Interacts with STAT3 following IL-6 stimulation (By similarity). Interacts with TRA (By similarity). Interacts with TRIP4 (By similarity). Interacts with TTLL5/STAMP (By similarity). Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity (By similarity). Interacts with VDR (By similarity).
messages: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response (By similarity).
messages: Nucleus
messages: Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein (By similarity).
messages: The C-terminal (1107-1447) part mediates the histone acetyltransferase (HAT) activity.
messages: Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites (By similarity).

9823:ACVR2B
gene id: 9823:ACVR2B
uniprot id: A0A287BJX6
uniprot id: A0A4X1TWT8
uniprot id: Q66T47
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Forms an activin receptor complex with activin type II receptors such as ACVR1B. Interacts with VPS39. Interacts with DYNLT1.
messages: Membrane
messages: Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity (By similarity).
messages: Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity).

9823:PSME1
gene id: 9823:PSME1
uniprot id: Q64L94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PA28 family.
messages: Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers (By similarity).
messages: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity).

9823:FABP1
gene id: 9823:FABP1
uniprot id: P49924
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: Monomer.
messages: Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.

9823:MPPE1
gene id: 9823:MPPE1
uniprot id: A0A481B239
uniprot id: A0A8D1W5F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10.
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

9823:WEE2
gene id: 9823:WEE2
uniprot id: A4PES0
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Continuous activation of WEE2 is a cause of meiotic failure of small oocytes. In mammals, oocytes with a diameter less than 80% of that of full-grown oocytes cannot start meiotic maturation (PubMed:19550110).
messages: Detected only in the oocytes throughout oocyte maturation period.
messages: Nucleus
messages: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
messages: Ovary-specific.
messages: Phosphorylation leads to increase its activity.

9823:E2F4
gene id: 9823:E2F4
uniprot id: A0A286ZZW3
uniprot id: A0A8D1T6B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9823:AMOT
gene id: 9823:AMOT
uniprot id: A0A480S534
uniprot id: A0A4X1VZZ3
names: Similarity
messages: Belongs to the angiomotin family.

9823:PRR15
gene id: 9823:PRR15
uniprot id: A0A4X1TGE5
uniprot id: F1SIG5
names: Similarity
messages: Belongs to the PRR15 family.

9823:TMEM150C
gene id: 9823:TMEM150C
uniprot id: A0A4X1TDF9
uniprot id: A0A4X1TDG4
uniprot id: A0A8D0K950
uniprot id: A0A8D0TZY2
names: Subcellular Location Annotation
messages: Membrane

9823:PDGFRA
gene id: 9823:PDGFRA
uniprot id: A0A4X1UD13
uniprot id: A0A8D0PMK2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9823:PABPC1L
gene id: 9823:PABPC1L
uniprot id: F1SDR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9823:TMEM255A
gene id: 9823:TMEM255A
uniprot id: A0A4X1W0G6
uniprot id: A0A4X1W5E5
uniprot id: A0A5G2QAW8
uniprot id: K7GNE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9823:NUP93
gene id: 9823:NUP93
uniprot id: A0A481B0D3
uniprot id: A0A8D0LY85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9823:SFRP5
gene id: 9823:SFRP5
uniprot id: A0A4X1U966
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DHX29
gene id: 9823:DHX29
uniprot id: A0A8D1NEY3
uniprot id: I3LQ47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

9823:IRF1
gene id: 9823:IRF1
uniprot id: A0FIN4
uniprot id: D2KC06
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by MYD88.
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Monomer (By similarity). Homodimer (By similarity). Interacts with EP300 (By similarity). Interacts with MYD88 (By similarity). Interacts with PIAS3 (By similarity).
messages: Nucleus
messages: Phosphorylated by CK2 and this positively regulates its activity.
messages: Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation (By similarity). Sumolyated by UBE2I/UBC9 and SUMO1 (By similarity). Inactivates the tumor suppressor activity (By similarity). Elevated levels in tumor cells. Major site is Lys-276 (By similarity). Sumoylation is enhanced by PIAS3 (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites (By similarity).
messages: Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (By similarity). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (By similarity). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Binds to a consensus sequence in gene promoters (By similarity). Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as GBP2, GBP5 and NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (By similarity). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (By similarity). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (By similarity). Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development a…
messages: Ubiquitinated. Appears to compete with sumoylation on C-terminal sites (By similarity).

9823:CRYAB
gene id: 9823:CRYAB
uniprot id: B1Q039
uniprot id: Q7M2W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Interacts with HSPBAP1 and TTN/titin. Interacts with TMEM109; in the cellular response to DNA damage. Interacts with DES; binds rapidly during early stages of DES filament assembly and a reduced binding seen in the later stages. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with ATP6V1A and with MTOR, forming a ternary complex (By similarity).
messages: Lysosome
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity).
messages: Nucleus
messages: Secreted

9823:GNPDA2
gene id: 9823:GNPDA2
uniprot id: A0A4X1UI84
uniprot id: A0A8D0JS89
uniprot id: A0A8D1NEL2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9823:ASIC5
gene id: 9823:ASIC5
uniprot id: A0A4X1U3N8
uniprot id: A0A8D0SU54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9823:SLC25A27
gene id: 9823:SLC25A27
uniprot id: A0A480X2I8
uniprot id: A0A4X1V4Z9
uniprot id: A0A8D0W2M8
uniprot id: D9IZY8
uniprot id: I3LSK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:LOC100520442
gene id: 9823:LOC100520442
uniprot id: A0A287ALI3
uniprot id: A0A4X1V971
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SEC63
gene id: 9823:SEC63
uniprot id: A0A8D0MIX6
uniprot id: F1RT28
names: Subcellular Location Annotation
messages: Membrane

9823:IFN-DELTA-2
gene id: 9823:IFN-DELTA-2
uniprot id: C8CKB2
uniprot id: Q29115
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:LOC100524598
gene id: 9823:LOC100524598
uniprot id: A0A8D1HMZ8
uniprot id: F1SG16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9823:CCRL2
gene id: 9823:CCRL2
uniprot id: Q75ZH0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
messages: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity).

9823:ADH5
gene id: 9823:ADH5
uniprot id: A0A8D1QD02
uniprot id: F1S0C1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

9823:TMOD3
gene id: 9823:TMOD3
uniprot id: A0A4X1T2H0
uniprot id: Q9N0Y9
names: Subcellular Location Annotation
messages: cytoskeleton

9823:PICK1
gene id: 9823:PICK1
uniprot id: A0A8D0SYV8
uniprot id: F1SKP0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

9823:TCEANC2
gene id: 9823:TCEANC2
uniprot id: A0A4X1WAX2
uniprot id: A0A8D1A189
names: Subcellular Location Annotation
messages: Nucleus

9823:KCNE3
gene id: 9823:KCNE3
uniprot id: A0A8D1K260
uniprot id: Q8MIS1
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9823:MYO5A
gene id: 9823:MYO5A
uniprot id: A0A480JT56
uniprot id: A0A480T559
uniprot id: A0A4X1T7R2
uniprot id: A0A4X1T7T9
uniprot id: A0A8D1CQI9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9823:IL15
gene id: 9823:IL15
uniprot id: A0A4X1VGX8
uniprot id: A0A4X1VJN4
uniprot id: M4M653
uniprot id: Q95253
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (By similarity). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).
messages: Secreted

9823:MGMT
gene id: 9823:MGMT
uniprot id: A0A287ATP1
uniprot id: A0A4X1VAC7
uniprot id: A0A4X1VAE7
uniprot id: F1SDK3
names: Function
names: Similarity
messages: Belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

9823:MYOCD
gene id: 9823:MYOCD
uniprot id: Q7YR76
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the heart and in smooth muscle cells-containing tissues (aorta, pulmonary vein, lung), but is not detectable in skeletal muscle, liver, kidney and spleen.
messages: Homodimer. Interacts with MLLT7/FOXO4. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation (By similarity). Interacts (via C-terminal) with EP300 (via the CREB-binding domain) (By similarity). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C (By similarity).
messages: Nucleus
messages: Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity.
messages: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).
messages: The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a basic and a Gln-rich domain, confers transcriptional potency and specificity by mediating association with the MADS box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation and ternary complex formation (By similarity).

9823:DMRTA1
gene id: 9823:DMRTA1
uniprot id: A0A4X1WCD4
uniprot id: F1SNK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9823:PAX9
gene id: 9823:PAX9
uniprot id: A0A480DYY0
uniprot id: A0A4X1TAS5
names: Subcellular Location Annotation
messages: Nucleus

9823:OGT
gene id: 9823:OGT
uniprot id: A0A8D0RX56
uniprot id: K7GSL3
uniprot id: Q27HV0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, ATG4B, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU, NOD2 and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (By similarity). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues. O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex. Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity …
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Homotrimer, oligomerizes via TPR repeats 6 and 7. Trimerization is not necessary for activity in vitro, however it increases affinity for UDP-GlcNAc (By similarity). Component of a THAP1/THAP3-HCFC1-OGT complex. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts directly with HCFC1; the interaction O-glycosylates HCFC1, regulates its proteolytic processing and transcriptional activity and, in turn, stabilizes OGT in the nucleus. Interacts (via TPRs 1-6) with SIN3A; the interaction mediates transcriptional repression in parallel with histone deacetylase. Interacts (via TPR 5-6) with TET1, TET2 and TET3 (By similarity). Interacts (via TPR repeats 6 and 7) with ATXN10 (By similarity). Interacts with histone H2B (By similarity). Interacts with BMAL1. Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with SINHCAF (By similarity). Component of a complex composed of KMT2E/MLL5, OGT and USP7; the complex stabilizes KMT2E/MLL5, preventing KMT2E/MLL5 ubiquitination and proteasomal-mediated degradation. Interacts (via TRP repeats) with KMT2E/MLL5 (via N-terminus). Interacts with USP7. Interacts with TRAK1; this interaction is not required for glycosylation of TRAK1 by this protein. Found in a complex with KIF5B, RHOT1, RHOT2 and TRAK1 (By similarity). Interacts (via TPR repeats domain) with HOXA1; the interaction takes place mainly in the nucleus (By similarity). Interacts with NSD2 (By similarity). Interacts with PROSER1; this interaction mediates TET2 O-GlcNAcylation and stability by promoting the interaction between OGT and TET2 (By similarity).
messages: Mitochondrion membrane
messages: Nucleus
messages: Phosphorylation on Ser-3 or Ser-4 by GSK3-beta positively regulates its activity.
messages: The TPR repeat domain is required for substrate binding and oligomerization.
messages: Ubiquitinated, leading to its proteasomal degradation.

9823:FGFR4
gene id: 9823:FGFR4
uniprot id: A0A4X1SFS2
uniprot id: F1S3B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9823:VWDE
gene id: 9823:VWDE
uniprot id: A0A8D0RFV9
uniprot id: A0A8D0RQH1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CPO
gene id: 9823:CPO
uniprot id: A0A8D0W9R9
uniprot id: A0A8D1IA37
names: Similarity
messages: Belongs to the peptidase M14 family.

9823:ADAMTS15
gene id: 9823:ADAMTS15
uniprot id: A0A8D1BAY0
uniprot id: F1S6D2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:HMGCS1
gene id: 9823:HMGCS1
uniprot id: A0A5K1UCS8
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9823:IP6K2
gene id: 9823:IP6K2
uniprot id: A0A4X1T105
uniprot id: A0A8D0PPQ7
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9823:NRG4
gene id: 9823:NRG4
uniprot id: A0A4X1TYN8
uniprot id: A0A8W4FCC1
names: Caution
names: Similarity
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100520926
gene id: 9823:LOC100520926
uniprot id: A0A8D0QVD4
uniprot id: A0A8D1HZC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PRKG2
gene id: 9823:PRKG2
uniprot id: A0A8D0VB77
uniprot id: F1RVC8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9823:GABRB2
gene id: 9823:GABRB2
uniprot id: A0A4X1TXI6
uniprot id: A0A4X1U2I4
uniprot id: A0A8D0M7E8
uniprot id: A0A8D1UTI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:ACER1
gene id: 9823:ACER1
uniprot id: A0A4X1VRI7
uniprot id: A0A8D0WRJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9823:AQP8
gene id: 9823:AQP8
uniprot id: A8WCF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:RPL35
gene id: 9823:RPL35
uniprot id: Q29361
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9823:AFF2
gene id: 9823:AFF2
uniprot id: A0A287A0H6
uniprot id: A0A480K3V4
uniprot id: A0A8D1A9C9
names: Similarity
messages: Belongs to the AF4 family.

9823:ZFPL1
gene id: 9823:ZFPL1
uniprot id: A0A8D1KF42
uniprot id: F1RQT4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

9823:C3
gene id: 9823:C3
uniprot id: P01025
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a chemoattractant for neutrophils in chronic inflammation.
messages: Adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in post-prandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-internalization and recycling of C5AR2 (By similarity).
messages: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (By similarity).
messages: C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). Forms the pro-C3-convertase enzyme complex by binding to Complement factor B Bb fragment (Bb), which is then stabilized by binding CFP, allowing the complex to become active (By similarity). The interaction with Bb is dependent on Mg2+ (By similarity). C3b interacts with CR1 (via Sushi 8 and Sushi 9 domains). C3b interacts with CFH. C3d interacts with CFH. C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with VSIG4. Interacts with S.aureus immunoglobulin-binding protein sbi, this prevents interaction between C3dg and CR2. Interacts with S.aureus fib. Interacts (both C3a and ASP) with C5AR2; the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of C5AR2, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.
messages: C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxylases to release the C-termianl arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by insulin and dietary chylomicrons (By similarity).
messages: Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity).
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Secreted

9823:FAM160B1
gene id: 9823:FAM160B1
uniprot id: A0A8D0QCY5
uniprot id: F1S4V3
names: Similarity
messages: Belongs to the FHIP family.

9823:UNC119B
gene id: 9823:UNC119B
uniprot id: A0A4X1T6U9
uniprot id: F1RJH3
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9823:HOXA2
gene id: 9823:HOXA2
uniprot id: A0A4X1TPJ8
uniprot id: F1SHT0
names: Subcellular Location Annotation
messages: Nucleus

9823:KIF19
gene id: 9823:KIF19
uniprot id: I3LEH8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:SUV39H2
gene id: 9823:SUV39H2
uniprot id: A0A287A6I1
uniprot id: A0A8D0NXY6
uniprot id: A0A8D0WCK3
uniprot id: Q27I49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9823:MTURN
gene id: 9823:MTURN
uniprot id: A0A286ZWP7
uniprot id: A0A8D0ZGG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTURN family.
messages: Cytoplasm

9823:CASK
gene id: 9823:CASK
uniprot id: A0A8D1ZHH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane

9823:POLR1A
gene id: 9823:POLR1A
uniprot id: A0A8D1IL37
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9823:LOC100524864
gene id: 9823:LOC100524864
uniprot id: A0A5G2QT77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100620442
gene id: 9823:LOC100620442
uniprot id: A0A8D1IA24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9823:LOC100518267
gene id: 9823:LOC100518267
uniprot id: A0A4X1SHH2
uniprot id: A0A5G2QFL3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:EPCAM
gene id: 9823:EPCAM
uniprot id: A0A1X9RRB4
uniprot id: Q75QW1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPCAM family.
messages: Cell membrane
messages: Glycosylation at Asn-198 is crucial for protein stability.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity).
messages: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
messages: Membrane
messages: Monomer. Interacts with phosphorylated CLDN7 (By similarity).
messages: tight junction

9823:TRAPPC6B
gene id: 9823:TRAPPC6B
uniprot id: A0A4X1SVM0
uniprot id: A0A8D2BYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9823:CRB2
gene id: 9823:CRB2
uniprot id: A0A8D0RS61
uniprot id: F1SKU3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100737069
gene id: 9823:LOC100737069
uniprot id: A0A5G2QJF9
uniprot id: A0A8D1AIE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PTH
gene id: 9823:PTH
uniprot id: P01269
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).
messages: Secreted

9823:CMTM5
gene id: 9823:CMTM5
uniprot id: A0A8D1Y371
names: Subcellular Location Annotation
messages: Membrane

9823:SPAST
gene id: 9823:SPAST
uniprot id: A0A8D0LXS3
uniprot id: A0A8D1HKC9
uniprot id: Q719N1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.
messages: Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Midbody
messages: Nucleus
messages: axon
messages: centrosome
messages: cytoskeleton
messages: perinuclear region
messages: spindle

9823:CLU
gene id: 9823:CLU
uniprot id: Q29549
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers. Interacts with a broad range of misfolded proteins, including APP, APOC2 and LYZ. Slightly acidic pH promotes interaction with misfolded proteins. Forms high-molecular weight oligomers upon interaction with misfolded proteins. Interacts with APOA1, LRP2, CLUAP1 and PON1. Interacts with the complement complex. Interacts (via alpha chain) with XRCC6. Interacts with SYVN1, COMMD1, BTRC, CUL1 and with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Interacts (via alpha chain) with BAX in stressed cells, where BAX undergoes a conformation change leading to association with the mitochondrial membrane. Does not interact with BAX in unstressed cells. Found in a complex with LTF, CLU, EPPIN and SEMG1. Interacts (immaturely glycosylated pre-secreted form) with HSPA5; this interaction promotes CLU stability and facilitates stress-induced CLU retrotranslocation from the secretory pathway to the mitochondria, thereby reducing stress-induced apoptosis by stabilizing mitochondrial membrane integrity. Interacts with BCL2L1; this interaction releases and activates BAX and promotes cell death. Interacts with TGFBR2 and ACVR1 (By similarity). Interacts (secreted form) with STMN3; this interaction may act as an important modulator during neuronal differentiation (By similarity). Interacts with VLDLR and LRP8 (By similarity).
messages: Belongs to the clusterin family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (By similarity). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity).
messages: Heavily N-glycosylated. About 30% of the protein mass is comprised of complex N-linked carbohydrate. Endoplasmic reticulum (ER) stress induces changes in glycosylation status and increases level of hypoglycosylated forms. Core carbohydrates are essential for chaperone activity. Non-secreted forms are hypoglycosylated or unglycosylated.
messages: Highest levels in brain and liver; lower levels are detected in other tissues, including the aorta. Abundant in senescent porcine pituitary colloids.
messages: Microsome
messages: Mitochondrion
messages: Mitochondrion membrane
messages: Nucleus
messages: Polyubiquitinated, leading to proteasomal degradation. Under cellular stress, the intracellular level of cleaved form is reduced due to proteasomal degradation.
messages: Proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen. Proteolytic cleavage is not necessary for its chaperone activity. All non-secreted forms are not proteolytically cleaved. Chaperone activity of uncleaved forms is dependent on a non-reducing envoronment.
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9823:LOC100738403
gene id: 9823:LOC100738403
uniprot id: A0A480J7X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9823:RETN
gene id: 9823:RETN
uniprot id: A0A4X1VP29
uniprot id: Q6QR67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9823:EOGT
gene id: 9823:EOGT
uniprot id: K9MA89
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

9823:ST13
gene id: 9823:ST13
uniprot id: A0A4X1VWC1
names: Similarity
messages: Belongs to the FAM10 family.

9823:ARL5B
gene id: 9823:ARL5B
uniprot id: A0A286ZX20
uniprot id: A0A8D1RFA2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9823:PREP
gene id: 9823:PREP
uniprot id: A0A480WGK4
uniprot id: P23687
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S9A family.
messages: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
messages: Cytoplasm
messages: The N-terminus is blocked.
messages: Ubiquitous.

9823:LOC100522686
gene id: 9823:LOC100522686
uniprot id: A0A4X1VJ80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TMEM176B
gene id: 9823:TMEM176B
uniprot id: A0A5G2Q8F1
uniprot id: A0A5G2R8T2
uniprot id: A0A8D1U6J8
names: Similarity
messages: Belongs to the TMEM176 family.

9823:PLTP
gene id: 9823:PLTP
uniprot id: Q8WMN7
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

9823:OAZ2
gene id: 9823:OAZ2
uniprot id: A0A8D2C852
uniprot id: B2CR16
names: Similarity
messages: Belongs to the ODC antizyme family.

9823:HBS1L
gene id: 9823:HBS1L
uniprot id: A0A8D0QSH2
uniprot id: A0A8D2C6Q7
names: Subcellular Location Annotation
messages: Cytoplasm

9823:DDX55
gene id: 9823:DDX55
uniprot id: A0A287AP74
uniprot id: A0A4X1UKV9
uniprot id: A0A4X1ULL1
uniprot id: F1RFL5
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9823:ILKAP
gene id: 9823:ILKAP
uniprot id: A0A287AVD8
uniprot id: A0A4X1T6K5
names: Similarity
messages: Belongs to the PP2C family.

9823:PKIG
gene id: 9823:PKIG
uniprot id: Q7YQJ4
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9823:S100A3
gene id: 9823:S100A3
uniprot id: A0A8D0UKB1
uniprot id: F1SFV6
names: Similarity
messages: Belongs to the S-100 family.

9823:PSMB10
gene id: 9823:PSMB10
uniprot id: A0A4X1UH60
uniprot id: Q1W2K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9823:SLCO1A2
gene id: 9823:SLCO1A2
uniprot id: A0A4X1VET9
uniprot id: A0A5K1U410
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:LOC100154782
gene id: 9823:LOC100154782
uniprot id: A0A4X1SNR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:LOC100517422
gene id: 9823:LOC100517422
uniprot id: A0A4X1T7R5
uniprot id: A0A8W4FQD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PAN3
gene id: 9823:PAN3
uniprot id: A0A480QQ86
uniprot id: A0A8D1DTH8
uniprot id: A0A8D1K5Y3
uniprot id: F1RSU6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Cytoplasm
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

9823:METAP2
gene id: 9823:METAP2
uniprot id: A0A8D1F8W4
uniprot id: I3LSP1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9823:CCL20
gene id: 9823:CCL20
uniprot id: A0A8D1VMA7
uniprot id: Q5K4L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:SLC13A1
gene id: 9823:SLC13A1
uniprot id: A0A287AWR1
uniprot id: A0A8D1K5K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9823:OPTC
gene id: 9823:OPTC
uniprot id: A0A4X1V4V4
uniprot id: Q8MIS4
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9823:PGR
gene id: 9823:PGR
uniprot id: D0EWS6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Nucleus
messages: Steroid hormone receptor involved in the regulation of eukaryotic gene expression which affects cellular proliferation and differentiation in target tissues.

9823:GPD1
gene id: 9823:GPD1
uniprot id: A0A4X1WCQ0
uniprot id: A0A8D0QAV5
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9823:HOMER2
gene id: 9823:HOMER2
uniprot id: A0A287B2S7
uniprot id: A0A4X1UN37
uniprot id: A0A4X1UPH9
uniprot id: A0A8D0IZW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9823:NUDT18
gene id: 9823:NUDT18
uniprot id: A0A8D1BBQ9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9823:VPS16
gene id: 9823:VPS16
uniprot id: A0A480V3F0
uniprot id: A0A4X1SGW4
uniprot id: A0A8D0U823
uniprot id: F1S8A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9823:YIPF2
gene id: 9823:YIPF2
uniprot id: A0A481CLA2
uniprot id: A0A4X1VD29
uniprot id: F1S589
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9823:KIF18B
gene id: 9823:KIF18B
uniprot id: A0A5G2QRZ8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:GPAT3
gene id: 9823:GPAT3
uniprot id: A0A287BKR7
uniprot id: A0A4X1TQJ3
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9823:RNF114
gene id: 9823:RNF114
uniprot id: Q6J1I8
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated. Polyubiquitinated in the presence of E2 enzymes UBE2D1, UBE2D2 and UBE2D3, but only monoubiquitinated in the presence of UBE2E1.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation. Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C. This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis (By similarity). Inhibits classical swine fever virus replication by mediating 'K27'-linked ubiquitination of viral NS4B and inducing its degradation via the proteasome (PubMed:31413123).
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
messages: Nucleus

9823:TOB1
gene id: 9823:TOB1
uniprot id: A0A8D0IG14
uniprot id: B2BE68
names: Similarity
messages: Belongs to the BTG family.

9823:NCAPH2
gene id: 9823:NCAPH2
uniprot id: F1RXT8
names: Similarity
messages: Belongs to the CND2 H2 (condensin-2 subunit 2) family.

9823:PDYN
gene id: 9823:PDYN
uniprot id: P01214
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
messages: Leumorphin has a typical opioid activity and may have anti-apoptotic effect.
messages: Secreted
messages: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

9823:CCNA2
gene id: 9823:CCNA2
uniprot id: D5HP13
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9823:LOC100152708
gene id: 9823:LOC100152708
uniprot id: A0A4X1VFH9
uniprot id: F1S7N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PLIN5
gene id: 9823:PLIN5
uniprot id: A0A4X1VLU6
uniprot id: B1PHQ9
names: Similarity
messages: Belongs to the perilipin family.

9823:OSBPL10
gene id: 9823:OSBPL10
uniprot id: A0A480I0X8
uniprot id: A0A8D0RA18
names: Similarity
messages: Belongs to the OSBP family.

9823:FZR1
gene id: 9823:FZR1
uniprot id: A0A4X1VSL5
uniprot id: Q5H7B9
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9823:USO1
gene id: 9823:USO1
uniprot id: A0A480JSR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

9823:EPHX2
gene id: 9823:EPHX2
uniprot id: Q6Q2C2
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
messages: Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:15308618). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (By similarity).
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited by 1-(1-acetylpiperidin-4-yl)-3-(4-(trifl uoromethoxy)phenyl)urea (TPAU), 1-cyclohexyl-3-dodecylurea (CDU), 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), 1-((3S, 5S, 7S)-adamantan-1-yl)-3-(5-(2-(2-ethoxyethoxy) ethoxy)pentyl)urea (AEPU), N-adamantyl-N[']-cyclohexyl urea (ACU), 4-(((1S, 4S)-4-(3-((3S, 5S, 7S)-adamantan-1-yl) ureido)cyclohexyl)oxy)benzoic acid (c-AUCB), 4-(((1R, 4R)-4-(3-((3S, 5S, 7S)-adamantan-1-yl)ureido)cyclohexyl)oxy)benzoic acid (t-AUCB), 4-(((1R, 4R)-4-(3-(4(trifluoromethoxy)phenyl)ureido)cyclohexyl)oxy)benzoic acid (t-TAUCB) and to a lesser extent by 8-(3-((3S, 5S, 7S)-adamantan-1-yl)ureido) octanoic acid (AUOA).
messages: Peroxisome
messages: The N-terminal domain has phosphatase activity. The C-terminal domain has epoxide hydrolase activity.
messages: The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation (By similarity).

9823:LOC100516720
gene id: 9823:LOC100516720
uniprot id: F1S7L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SETD6
gene id: 9823:SETD6
uniprot id: A0A4X1UXW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Protein-lysine N-methyltransferase.

9823:HSP90AB1
gene id: 9823:HSP90AB1
uniprot id: A0A4X1V534
uniprot id: A0A8D1I190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9823:RIPOR2
gene id: 9823:RIPOR2
uniprot id: A0A286ZIL0
uniprot id: A0A286ZJE0
uniprot id: A0A4X1VMC2
uniprot id: A0A4X1VMC9
uniprot id: A0A4X1VMD4
uniprot id: A0A4X1VNK6
names: Similarity
messages: Belongs to the RIPOR family.

9823:LOC100512836
gene id: 9823:LOC100512836
uniprot id: A0A8D1LVN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GHRH
gene id: 9823:GHRH
uniprot id: A0A8D1EPS5
uniprot id: E0Y439
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9823:SLC9A6
gene id: 9823:SLC9A6
uniprot id: A0A481B7Y0
uniprot id: A0A4X1SEX9
uniprot id: A0A8D1S7I2
uniprot id: K7GPQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Recycling endosome membrane

9823:LOC100525311
gene id: 9823:LOC100525311
uniprot id: A0A287A3F2
uniprot id: A0A4X1TGD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9823:MC3R
gene id: 9823:MC3R
uniprot id: A0A8D1YT97
uniprot id: A5GFS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9823:OVOL1
gene id: 9823:OVOL1
uniprot id: A0A4X1UIC6
uniprot id: F1RU16
names: Subcellular Location Annotation
messages: Nucleus

9823:DDIT3
gene id: 9823:DDIT3
uniprot id: A0A8D1B7X1
uniprot id: B8Q504
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9823:PAN2
gene id: 9823:PAN2
uniprot id: A0A287AC03
uniprot id: A0A4X1W369
uniprot id: A0A4X1W8L2
uniprot id: A0A8D0LNJ2
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

9823:SIGMAR1
gene id: 9823:SIGMAR1
uniprot id: A0A287BCF9
uniprot id: A0A8D0SNA5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle
messages: growth cone

9823:LOC100156674
gene id: 9823:LOC100156674
uniprot id: A0A8D1JBR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9823:CDC25C
gene id: 9823:CDC25C
uniprot id: Q29029
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity).
messages: Interacts with MAPK14 and 14-3-3 proteins (By similarity). When phosphorylated at Ser-122 and/or Thr-123, interacts with PLK1 (By similarity). Interacts with MARK3/C-TAK1 (By similarity).
messages: Nucleus
messages: Phosphorylated by CHEK1 and MAPK14 at Ser-245. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase (By similarity). Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-217 promotes nuclear translocation. Ser-224 is a minor phosphorylation site (By similarity). Phosphorylation by CDK1 occurs at G2 and G2-M transition and leads to increased activity (By similarity).

9823:GPC2
gene id: 9823:GPC2
uniprot id: F1RNM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9823:INTS14
gene id: 9823:INTS14
uniprot id: A0A4X1THU5
uniprot id: A0A8D0Q7B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9823:SRPK3
gene id: 9823:SRPK3
uniprot id: B8Y466
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily.
messages: Highly expressed in skeletal muscle, heart, uterus and parorchis. Weakly expressed in brain, stomach, small intestine and ovary.
messages: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).

9823:CAMK2G
gene id: 9823:CAMK2G
uniprot id: A0A8D1MEG3
uniprot id: A0A8D1RV00
uniprot id: A0A8D1RVW6
uniprot id: A0A8D1TEB7
uniprot id: Q7JFN2
uniprot id: Q7JFN3
uniprot id: Q7JFN4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9823:DCLK3
gene id: 9823:DCLK3
uniprot id: A0A4X1U1Z3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9823:CLCN7
gene id: 9823:CLCN7
uniprot id: A0A5G2QUV5
uniprot id: A0A8D1AC75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9823:PLSCR1
gene id: 9823:PLSCR1
uniprot id: F4ZS19
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9823:NLRP3
gene id: 9823:NLRP3
uniprot id: A0A8D1EM40
uniprot id: H2EW08
names: Similarity
messages: Belongs to the NLRP family.

9823:TBX21
gene id: 9823:TBX21
uniprot id: A0A8D0QMW5
uniprot id: M5AJM4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:LOC100153093
gene id: 9823:LOC100153093
uniprot id: A0A8D1H6D6
uniprot id: F1RKY6
names: Similarity
messages: Belongs to the RIMBP family.

9823:MYMK
gene id: 9823:MYMK
uniprot id: A0A8D0J184
uniprot id: I3LUN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9823:ADSS
gene id: 9823:ADSS
uniprot id: A4Z6H1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited competitively by AMP and IMP and non-competitively by fructose 1,6-bisphosphate.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Widely expressed.

9823:FANCM
gene id: 9823:FANCM
uniprot id: A0A8D1TK32
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

9823:SCAP
gene id: 9823:SCAP
uniprot id: A0A287B848
uniprot id: A0A8D1KXU4
uniprot id: A0A8D1MC93
uniprot id: F1SNT3
uniprot id: Q5MNU5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat SCAP family.
messages: COPII-coated vesicle membrane
messages: Cholesterol bound to SSD domain of SCAP or oxysterol bound to INSIG (INSIG1 or INSIG2) leads to masking of an ER export signal (also named MELADL motif) on SCAP possibly by moving the signal further away from the ER membrane.
messages: Endoplasmic reticulum membrane
messages: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.
messages: Expressed in liver and muscle. Isoform 3 expressed in testis.
messages: Expressed in testis.
messages: Golgi apparatus membrane
messages: Loop-1 binds to loop-7, enabling interaction with COPII-coated vesicles. When levels of cholesterol in the endoplasmic reticulum increase, Loop-1 binds to cholesterol instead, thereby disrupting direct binding between the two loops and preventing the SCAP-SREBP complex from exiting the endoplasmic reticulum.
messages: Membrane region forms a homotetramer (By similarity). Forms a stable complex with SREBF1/SREBP1 or SREBF2/SREBP2 through its C-terminal cytoplasmic domain (By similarity). Forms a ternary complex with INSIG1 or INSIG2 through its transmembrane domains at high sterol concentrations (By similarity). Interacts with the SEC23-SEC24 complex in a SAR1-GTP-dependent manner through an ER export signal in its third cytoplasmic loop (By similarity). Binds cholesterol through its SSD domain (By similarity). Component of SCAP-SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing (By similarity). Interacts with RNF139; the interaction inhibits the interaction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP-SREBP complex (By similarity). Interacts with SPRING1 (By similarity).
messages: Ubiquitinated at Lys-454 and Lys-466. RNF145 triggers ubiquitination of SCAP, likely inhibiting SCAP-SREBP complex transport to the Golgi apparatus and the subsequent processing/maturation of SREBF2/SREBP2.
messages: Widely expressed with higher levels in lung, kidney, gut, brain and adipose tissue.

9823:TSPAN9
gene id: 9823:TSPAN9
uniprot id: Q06AA5
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Found in a complex with GP6.
messages: Glycosylated.
messages: Membrane

9823:ADGRG5
gene id: 9823:ADGRG5
uniprot id: A0A8D0PQQ2
names: Subcellular Location Annotation
messages: Membrane

9823:DSC1
gene id: 9823:DSC1
uniprot id: A0A8D1AR94
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9823:TMEM234
gene id: 9823:TMEM234
uniprot id: A0A481BBG1
uniprot id: A0A4X1VZD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

9823:TM7SF2
gene id: 9823:TM7SF2
uniprot id: A0A480QTI0
uniprot id: A0A8D0LHC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9823:NCOA7
gene id: 9823:NCOA7
uniprot id: A0A5K1U8K2
uniprot id: A0A8D0YHB8
uniprot id: A0A8D1CCK3
uniprot id: F1S2V5
names: Similarity
messages: Belongs to the OXR1 family.

9823:NAGPA
gene id: 9823:NAGPA
uniprot id: A0A8D1TBE0
uniprot id: F1RK92
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:KDM1A
gene id: 9823:KDM1A
uniprot id: A8WC96
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

9823:LOC102166240
gene id: 9823:LOC102166240
uniprot id: A0A8D0RWZ4
uniprot id: I3LNR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9823:KDM5C
gene id: 9823:KDM5C
uniprot id: A0A8D1CN82
uniprot id: A1YVX4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the JARID1 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Both the JmjC domain and the JmjN domain are required for enzymatic activity.
messages: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (By similarity).
messages: Nucleus
messages: Part of two distinct complexes, one containing E2F6, and the other containing REST. Interacts with ZMYND8.
messages: The first PHD-type zinc finger domain recognizes and binds H3-K9Me3.

9823:PDSS1
gene id: 9823:PDSS1
uniprot id: A0A8D1D4I1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9823:LOC100157239
gene id: 9823:LOC100157239
uniprot id: A0A4X1VUW5
uniprot id: A0A5G2QXK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LMCD1
gene id: 9823:LMCD1
uniprot id: Q5PXT2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Highly expressed in both skeletal muscle and cardiac muscle.
messages: Interacts with beta-dystroglycan. Interacts with GATA1, GATA4 and GATA6 (By similarity).
messages: Nucleus
messages: The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6.
messages: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway (By similarity).

9823:SPP2
gene id: 9823:SPP2
uniprot id: Q711S8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Multiply phosphorylated at serine residues.
messages: Phosphorylation sites are present in the extracellular medium.
messages: Secreted

9823:SPACA4
gene id: 9823:SPACA4
uniprot id: A0A8D0XCF2
uniprot id: D5K890
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9823:RNF19A
gene id: 9823:RNF19A
uniprot id: Q2VJ60
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. RNF19 subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR.
messages: Interacts with UBE2L3 and UBE2L6. Also interacts with transcription factor Sp1. Interacts with SNCAIP, CASR and VCP (By similarity).
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
messages: Membrane
messages: centrosome

9823:GDI1
gene id: 9823:GDI1
uniprot id: A0A4X1T6D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9823:CPA1
gene id: 9823:CPA1
uniprot id: A0A4X1VSS2
uniprot id: P09954
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity). Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (By similarity).
messages: Monomer. May form a complex with proelastase 2.
messages: Secreted

9823:ARL4D
gene id: 9823:ARL4D
uniprot id: A0A8D1ZVQ3
uniprot id: F1S1H1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9823:SPDYC
gene id: 9823:SPDYC
uniprot id: A0A286ZLZ4
uniprot id: A0A8D0TG89
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9823:ATP1B1
gene id: 9823:ATP1B1
uniprot id: P05027
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Glutathionylated (By similarity). N-glycosylated (By similarity).
messages: Involved in cell adhesion and establishing epithelial cell polarity.
messages: The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic subunit ATP12A (By similarity). Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (By similarity). Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM. Interacts with KIRREL3 (By similarity). Interacts with OBSCN (via protein kinase domain 1) (By similarity). Interacts with TRAF3 and TRAF6 (By similarity).
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1.
messages: sarcolemma

9823:LOC100519710
gene id: 9823:LOC100519710
uniprot id: A0A4X1VVK1
uniprot id: A0A5G2QR19
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ERLEC1
gene id: 9823:ERLEC1
uniprot id: A0A287B0P2
uniprot id: A0A8D0M5C7
uniprot id: A0A8D0TM32
uniprot id: A0A8D1KFT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

9823:ERMP1
gene id: 9823:ERMP1
uniprot id: A0A287A5Y2
uniprot id: A0A4X1W8V6
uniprot id: A0A8D1ZSS5
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100517700
gene id: 9823:LOC100517700
uniprot id: F1S3F9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NGDN
gene id: 9823:NGDN
uniprot id: A0A4X1SIH2
uniprot id: A0A8D0TH53
names: Subcellular Location Annotation
messages: nucleolus

9823:MUT
gene id: 9823:MUT
uniprot id: Q8MI68
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.
messages: Cytoplasm
messages: Homodimer. Interacts (the apoenzyme form) with MMAA; the interaction is GTP dependent.
messages: Inhibited by itaconyl-CoA, a metabolite that inactivates the coenzyme B12 cofactor.
messages: Mitochondrion
messages: Mitochondrion matrix

9823:AP3B1
gene id: 9823:AP3B1
uniprot id: A5A767
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9823:CHI3L1
gene id: 9823:CHI3L1
uniprot id: Q29411
names: Caution
names: Function
names: Induction
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although it belongs to the glycosyl hydrolase 18 family, Leu-140 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity.
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity). Stimulates migration and adhesion of cultured vascular smooth muscle cells.
messages: Cytoplasm
messages: Detected in smooth muscle cells in atherosclerotic plaques. Detected in regions of vascular occlusion in the aorta.
messages: Endoplasmic reticulum
messages: Monomer.
messages: Sequencing errors.
messages: Up-regulated in cultured aortic smooth muscle cells upon transition to a nodular, multilayered culture.
messages: extracellular space
messages: perinuclear region

9823:TFF2
gene id: 9823:TFF2
uniprot id: A0A4X1TI83
uniprot id: A0A8D1L5W7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CRTC2
gene id: 9823:CRTC2
uniprot id: A0A8D2A0K4
uniprot id: F1SFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9823:CDCA5
gene id: 9823:CDCA5
uniprot id: A0A480JPV6
uniprot id: A0A4X1V334
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9823:CD79A
gene id: 9823:CD79A
uniprot id: A0A8D1QJ52
uniprot id: B5QTD1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:LMNA
gene id: 9823:LMNA
uniprot id: A0A287AE06
uniprot id: A0A8D1MMD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9823:TF
gene id: 9823:TF
uniprot id: A0A8D0PY93
uniprot id: A0A8D1SNW7
uniprot id: Q29545
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transferrin family.
messages: Blood plasma (at protein level).
messages: Inhibitor for carbonic anhydrase 2 (CA2) (PubMed:1463741, PubMed:18712936). Does not bind iron ions (By similarity).
messages: Monomer (PubMed:1463741). Interacts (via transferrin-like domain 2) with CA2 (By similarity).
messages: Monomer.
messages: N-glycosylated.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

9823:DIO1
gene id: 9823:DIO1
uniprot id: Q6QN13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iodothyronine deiodinase family.
messages: Endoplasmic reticulum membrane
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

9823:TRPM7
gene id: 9823:TRPM7
uniprot id: A0A4X1SXJ2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

9823:FOXI1
gene id: 9823:FOXI1
uniprot id: A0A8D0SVM4
uniprot id: F1RR95
names: Subcellular Location Annotation
messages: Nucleus

9823:DNTT
gene id: 9823:DNTT
uniprot id: A0A4X1UFW0
uniprot id: F1SBG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.

9823:SLC6A13
gene id: 9823:SLC6A13
uniprot id: A0A8D0YZT0
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9823:LPCAT4
gene id: 9823:LPCAT4
uniprot id: A0A5G2R2A1
uniprot id: A0A8D1CSV5
uniprot id: C0KEG5
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9823:DBH
gene id: 9823:DBH
uniprot id: A0A4X1SZ01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Conversion of dopamine to noradrenaline.
messages: Homotetramer; composed of two disulfide-linked dimers.
messages: chromaffin granule lumen
messages: chromaffin granule membrane
messages: secretory vesicle lumen
messages: secretory vesicle membrane

9823:TUBA1A
gene id: 9823:TUBA1A
uniprot id: A0A4X1WCL8
uniprot id: A0A8D1E8F5
uniprot id: B6A7R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9823:DPY19L2
gene id: 9823:DPY19L2
uniprot id: A0A4X1W164
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9823:PTPRE
gene id: 9823:PTPRE
uniprot id: A0A8D1KJ71
uniprot id: F1SDK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

9823:MCHR2
gene id: 9823:MCHR2
uniprot id: A0A8D0KIF8
uniprot id: A0A8D1VDP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:IPO13
gene id: 9823:IPO13
uniprot id: A0A8D0MN67
uniprot id: M3VK27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

9823:SCNN1G
gene id: 9823:SCNN1G
uniprot id: A0A8D1WXS6
uniprot id: F1RPF1
names: Subcellular Location Annotation
messages: Membrane

9823:TMEM216
gene id: 9823:TMEM216
uniprot id: A0A287AG87
uniprot id: A0A4X1VP00
uniprot id: A0A8D0V353
uniprot id: A0A8D1UQI1
names: Subcellular Location Annotation
messages: Membrane

9823:CD34
gene id: 9823:CD34
uniprot id: Q8WMG9
names: Subcellular Location Annotation
messages: Membrane

9823:MOG
gene id: 9823:MOG
uniprot id: E2JL22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9823:ACSS2
gene id: 9823:ACSS2
uniprot id: A0A287BEZ5
uniprot id: A0A8D1H621
uniprot id: B8XY19
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:LOC100524011
gene id: 9823:LOC100524011
uniprot id: A0A5G2QUE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ODF1
gene id: 9823:ODF1
uniprot id: F2Y3N8
uniprot id: Q29077
names: Domain
names: Function
names: Subunit
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.
messages: Interacts (via leucine zipper motif) with TCP11 (By similarity). Interacts with SPAG4 (By similarity). Interacts with KLC3 (By similarity).
messages: The C-terminal contains many C-X-P repeats.

9823:SNX10
gene id: 9823:SNX10
uniprot id: A0A8D0PN10
uniprot id: F2Z5P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9823:LOC100514671
gene id: 9823:LOC100514671
uniprot id: A0A4X1VIB9
uniprot id: F1S806
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MAGOHB
gene id: 9823:MAGOHB
uniprot id: A0A4X1V2Y4
uniprot id: F1SQ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9823:LOC100628183
gene id: 9823:LOC100628183
uniprot id: A0A5G2R808
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MC4R
gene id: 9823:MC4R
uniprot id: O97504
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ATRNL1 (By similarity). Homodimer; disulfide-linked, also forms higher order oligomers. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with MRAP and MRAP2; these associated factors increase ligand-sensitivity and generation of cAMP (By similarity).
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9823:STARD5
gene id: 9823:STARD5
uniprot id: A0A8D1BUF6
uniprot id: F1RID6
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9823:PTPN11
gene id: 9823:PTPN11
uniprot id: A0A480ERB4
uniprot id: A0A480LMF4
uniprot id: A0A4X1TG72
uniprot id: A0A8D1HDC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9823:STMN1
gene id: 9823:STMN1
uniprot id: Q6DUB7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the stathmin family.
messages: Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST (By similarity).
messages: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
messages: Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity).
messages: cytoskeleton

9823:LOC100520680
gene id: 9823:LOC100520680
uniprot id: A0A8D1G4W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9823:MTR
gene id: 9823:MTR
uniprot id: A0A8D1Y7H2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

9823:CREG2
gene id: 9823:CREG2
uniprot id: A0A4X1W203
uniprot id: F1STG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9823:PTAFR
gene id: 9823:PTAFR
uniprot id: A0A287B7B1
uniprot id: A0A8D1Y0G6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9823:LIMS2
gene id: 9823:LIMS2
uniprot id: A0A480W7H2
uniprot id: A0A4X1VR23
uniprot id: A0A8D0JMC7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9823:SLC35B2
gene id: 9823:SLC35B2
uniprot id: A0A4X1V5X1
uniprot id: F1RQU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9823:IFN-DELTA-8
gene id: 9823:IFN-DELTA-8
uniprot id: A0A4X1WCC1
uniprot id: I3LKN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:MDC1
gene id: 9823:MDC1
uniprot id: Q767L8
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Homodimer. Interacts with several proteins involved in the DNA damage response, although not all these interactions may be direct. Interacts with H2AX, which requires phosphorylation of H2AX. Interacts with the MRN complex, composed of MRE11, RAD50, and NBN. Interacts with CHEK2, which requires ATM-mediated phosphorylation within the FHA domain of CHEK2. Interacts constitutively with the BRCA1-BARD1 complex, SMC1A and TP53BP1. Interacts with ATM and FANCD2, and these interactions are reduced upon DNA damage. Also interacts with the PRKDC complex, composed of XRCC6/KU70, XRCC5/KU80 and PRKDC/XRCC7. This interaction may be required for PRKDC autophosphorylation, which is essential for DNA double strand break (DSB) repair. When phosphorylated by ATM, interacts with RNF8 (via FHA domain). Interacts with CEP164. When phosphorylated, interacts with APTX (via FHA-like domain) (By similarity).
messages: Nucleus
messages: Phosphorylated upon exposure to ionizing radiation (IR), ultraviolet radiation (UV), and hydroxyurea (HU). Phosphorylation in response to IR requires ATM, NBN, and possibly CHEK2. Also phosphorylated during the G2/M phase of the cell cycle and during activation of the mitotic spindle checkpoint. Phosphorylation at Thr-4 by ATM stabilizes and enhances homodimerization via the FHA domain (By similarity).
messages: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (By similarity).
messages: Sumoylation by PIAS4 following DNA damage promotes ubiquitin-mediated degradation.
messages: Tandemly repeated BRCT domains are characteristic of proteins involved in DNA damage signaling. In MDC1, these repeats are required for localization to chromatin which flanks sites of DNA damage marked by 'Ser-139' phosphorylation of H2AX (By similarity).
messages: Ubiquitinated by RNF4, leading to proteasomal degradation; undergoes 'Lys-48'-linked polyubiquitination.

9823:RITA1
gene id: 9823:RITA1
uniprot id: A0A287BD58
uniprot id: A0A8D0MBD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RITA family.
messages: Cytoplasm
messages: Interacts with RBPJ/RBPSUH.
messages: Nucleus
messages: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

9823:PARP9
gene id: 9823:PARP9
uniprot id: A0A8D1RY71
names: Similarity
messages: Belongs to the ARTD/PARP family.

9823:FOXA1
gene id: 9823:FOXA1
uniprot id: A0A287AEQ3
uniprot id: A0A4X1TF89
names: Subcellular Location Annotation
messages: Nucleus

9823:MARCO
gene id: 9823:MARCO
uniprot id: A0A4X1SMC4
uniprot id: A0A8D1R4J2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:CCDC22
gene id: 9823:CCDC22
uniprot id: A0A5G2RD19
uniprot id: A0A8D1TN58
names: Similarity
messages: Belongs to the CCDC22 family.

9823:LOC100514306
gene id: 9823:LOC100514306
uniprot id: A0A286ZYL6
uniprot id: A0A8D1XFL3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SRD5A2
gene id: 9823:SRD5A2
uniprot id: O18765
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity).
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9823:PNN
gene id: 9823:PNN
uniprot id: A0A4X1SUU5
uniprot id: A0A8D0PLD0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pinin family.
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.
messages: Nucleus speckle
messages: desmosome

9823:HAT1
gene id: 9823:HAT1
uniprot id: A0A480SKM4
uniprot id: A0A4X1V891
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9823:TRIM54
gene id: 9823:TRIM54
uniprot id: G0WLG4
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9823:FBLN1
gene id: 9823:FBLN1
uniprot id: A0A480HZK3
uniprot id: A0A4X1W4U1
uniprot id: A0A8D1FL72
uniprot id: F1SM61
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibulin family.
messages: Homomultimerizes and interacts with various extracellular matrix components.
messages: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:MAP2K1
gene id: 9823:MAP2K1
uniprot id: B8XSJ8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:DRD2
gene id: 9823:DRD2
uniprot id: A0A4X1T900
uniprot id: F1SM69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9823:FXYD3
gene id: 9823:FXYD3
uniprot id: A0A8D0NC87
uniprot id: O97797
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes.
messages: Belongs to the FXYD family.
messages: Cell membrane
messages: Glutathionylated.
messages: Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic alpha subunit ATP1A1. Also interacts with non-catalytic beta subunit ATP1B1. Interacts with the alpha1-beta1, alpha2-beta1 and alpha3-beta1 NKA isozymes.

9823:POP4
gene id: 9823:POP4
uniprot id: A0A480XEX1
uniprot id: A0A4X1TRB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9823:IL28B
gene id: 9823:IL28B
uniprot id: A0A8D0R842
uniprot id: D0FHA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9823:PPP1R11
gene id: 9823:PPP1R11
uniprot id: A0A8D1I3N7
uniprot id: B6ICU5
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

9823:PKN1
gene id: 9823:PKN1
uniprot id: A0A287BRF6
uniprot id: A0A4X1V4I5
uniprot id: A0A4X1V693
uniprot id: F1SCG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9823:BRS3
gene id: 9823:BRS3
uniprot id: A0A4X1SFP0
uniprot id: A0A8D1S5J6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9823:BCO2
gene id: 9823:BCO2
uniprot id: A0A8D1QGF1
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

9823:NCK2
gene id: 9823:NCK2
uniprot id: A0A8D0NVV2
uniprot id: B6E314
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9823:AKAP4
gene id: 9823:AKAP4
uniprot id: A0A4X1SKT8
names: Similarity
messages: Belongs to the AKAP110 family.

9823:GKAP1
gene id: 9823:GKAP1
uniprot id: A0A480PA23
uniprot id: A0A4X1UWZ3
uniprot id: A0A8D0IN93
uniprot id: A0A8D0PCK8
uniprot id: I3LGA9
names: Similarity
messages: Belongs to the GKAP1 family.

9823:PANX3
gene id: 9823:PANX3
uniprot id: A0A4X1VH71
uniprot id: A0A8D0ZDJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9823:PSME3
gene id: 9823:PSME3
uniprot id: A0A4X1TXU2
uniprot id: A0A8D0IIT0
uniprot id: K9IWE8
uniprot id: P61291
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1 (By similarity).
messages: Belongs to the PA28 family.
messages: Cytoplasm
messages: Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with p53/TP53, MDM2 and MAP3K3. Associates with the proteasome. Interacts with CCAR2. Interacts with PSME3IP1 (via C-terminus); the interaction is direct and promotes the association of PSME3 with the 20S proteasome. Interacts with COIL; the interaction is inhibited by PSME3IP1.
messages: Nucleus
messages: Phosphorylated by MAP3K3. Phosphorylation at Ser-247 promotes its association with CCAR2.
messages: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity).
messages: The C-terminal sequences affect heptamer stability and proteasome affinity.

9823:LOC100524554
gene id: 9823:LOC100524554
uniprot id: A0A4X1W253
uniprot id: A0A4X1W313
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9823:LOC100524947
gene id: 9823:LOC100524947
uniprot id: A0A4X1VHK3
uniprot id: A0A8D1Y4E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RNF4
gene id: 9823:RNF4
uniprot id: A0A286ZYA4
uniprot id: A0A8D0NJK3
uniprot id: Q1L1E0
names: Subcellular Location Annotation
messages: Nucleus

9823:ATP6V0D2
gene id: 9823:ATP6V0D2
uniprot id: A0A4X1UE85
uniprot id: F1RXD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9823:SH3GL3
gene id: 9823:SH3GL3
uniprot id: I3LPZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9823:PSMD3
gene id: 9823:PSMD3
uniprot id: A0A4X1UAW4
uniprot id: F1RXA7
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9823:CSF3
gene id: 9823:CSF3
uniprot id: O02837
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity).
messages: Monomer.
messages: O-glycosylated.
messages: Secreted

9823:COX5B
gene id: 9823:COX5B
uniprot id: Q5S3G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5B family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9823:GCLC
gene id: 9823:GCLC
uniprot id: A0A480K1F4
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

9823:AMBP
gene id: 9823:AMBP
uniprot id: A0A480P2R0
uniprot id: A0A4X1V0L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: cytosol
messages: extracellular matrix

9823:RPS13
gene id: 9823:RPS13
uniprot id: A0A480V540
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9823:FMO1
gene id: 9823:FMO1
uniprot id: A0A480Y4M1
uniprot id: P16549
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMO family.
messages: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (PubMed:7758472). Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (By similarity). In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (By similarity).
messages: Endoplasmic reticulum membrane
messages: Liver.
messages: Membrane

9823:HK2
gene id: 9823:HK2
uniprot id: Q1W674
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hexokinase family.
messages: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
messages: Hexokinase activity is specifically inhibited by 2,6-disubstituted glucosamines.
messages: Mitochondrion outer membrane
messages: Monomer (By similarity). Interacts with TIGAR; the interaction increases hexokinase activity in a hypoxia- and HIF1A-dependent manner (By similarity).
messages: The N- and C-terminal halves of the protein contain a hexokinase domain. In contrast to hexokinase-1 and -3 (HK1 and HK3, respectively), both hexokinase domains display catalytic activity. The region connecting the two hexokinase domains is required for the catalytic activity of the N-terminal hexokinase domain. The N-terminal half regulates stability of the whole enzyme.
messages: cytosol

9823:MGP
gene id: 9823:MGP
uniprot id: D3Y2W1
uniprot id: Q8MJ39
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9823:MFSD6
gene id: 9823:MFSD6
uniprot id: A0A480KQQ8
uniprot id: A1DWM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9823:TMEM38B
gene id: 9823:TMEM38B
uniprot id: A0A286ZVK0
uniprot id: A0A8D0HL24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9823:HSF1
gene id: 9823:HSF1
uniprot id: A0A4X1URB1
uniprot id: F1RSM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9823:PAQR6
gene id: 9823:PAQR6
uniprot id: A0A4X1VTI6
uniprot id: A0A8D1INI6
uniprot id: F1RP12
uniprot id: G8XQW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:SOX11
gene id: 9823:SOX11
uniprot id: A0A8D0S848
uniprot id: F1S9L1
names: Subcellular Location Annotation
messages: Nucleus

9823:VPS45
gene id: 9823:VPS45
uniprot id: A0A4X1SHS6
uniprot id: A0A8D0MDV8
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9823:OCA2
gene id: 9823:OCA2
uniprot id: Q8MIQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation. One of the components of the mammalian pigmentary system. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color (By similarity). Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis (By similarity).
messages: Melanosome membrane

9823:ADAMTS20
gene id: 9823:ADAMTS20
uniprot id: H9BR48
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:HTT
gene id: 9823:HTT
uniprot id: Q9GM99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the huntingtin family.
messages: Cytoplasm
messages: May play a role in microtubule-mediated transport or vesicle function.
messages: Nucleus

9823:LRRC8A
gene id: 9823:LRRC8A
uniprot id: A0A4X1TJT1
uniprot id: A0A8D0XBM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9823:PRKAA2
gene id: 9823:PRKAA2
uniprot id: C9W108
uniprot id: Q28948
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity). Interacts with DUSP29 (By similarity).
messages: Activated by phosphorylation on Thr-172. Binding of AMP to non-catalytic gamma subunit (PRKAG1, PRKAG2 or PRKAG3) results in allosteric activation, inducing phosphorylation on Thr-172. AMP-binding to gamma subunit also sustains activity by preventing dephosphorylation of Thr-172. ADP also stimulates Thr-172 phosphorylation, without stimulating already phosphorylated AMPK. ATP promotes dephosphorylation of Thr-172, rendering the enzyme inactive. Under physiological conditions AMPK mainly exists in its inactive form in complex with ATP, which is much more abundant than AMP. Selectively inhibited by compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyyrazolo[1,5-a] pyrimidine. Activated by resveratrol, a natural polyphenol present in red wine, and S17834, a synthetic polyphenol. Salicylate/aspirin directly activates kinase activity, primarily by inhibiting Thr-172 dephosphorylation (By similarity).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (By similarity). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (By similarity). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient lim…
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated at Thr-172 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-172 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-172, but at much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK (By similarity). Dephosphorylated by PPM1A and PPM1B at Thr-172 (mediated by STK11/LKB1) (By similarity).
messages: The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.
messages: Ubiquitinated.

9823:RNASE1
gene id: 9823:RNASE1
uniprot id: A0A8D0QK08
uniprot id: D0PSF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9823:MEA1
gene id: 9823:MEA1
uniprot id: A0A1B2TT57
uniprot id: Q95313
names: Caution
names: Function
messages: It is uncertain whether Met-1 or Met-11 is the initiator.
messages: May play an important role in spermatogenesis and/or testis development.

9823:LOC100512154
gene id: 9823:LOC100512154
uniprot id: A0A8D1JLG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:OSBPL6
gene id: 9823:OSBPL6
uniprot id: A0A8D0M2P7
uniprot id: A0A8D0RXG1
uniprot id: A0A8D0V9W1
uniprot id: A0A8D1VER8
names: Similarity
messages: Belongs to the OSBP family.

9823:MAL2
gene id: 9823:MAL2
uniprot id: A0A4X1T956
uniprot id: C3UP60
names: Subcellular Location Annotation
messages: Membrane

9823:BMS1
gene id: 9823:BMS1
uniprot id: A0A4X1U1W8
names: Subcellular Location Annotation
messages: nucleolus

9823:MYL4
gene id: 9823:MYL4
uniprot id: F1RRT2
names: Function
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.
messages: Regulatory light chain of myosin. Does not bind calcium.

9823:PIAS4
gene id: 9823:PIAS4
uniprot id: A0A4X1VM99
uniprot id: I3LNY9
names: Similarity
messages: Belongs to the PIAS family.

9823:KEF22 p09
gene id: 9823:KEF22_p09
uniprot id: Q35914
uniprot id: Q7IIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9823:SERPINI2
gene id: 9823:SERPINI2
uniprot id: A0A4X1VEQ2
uniprot id: F1SH45
names: Similarity
messages: Belongs to the serpin family.

9823:TSPAN14
gene id: 9823:TSPAN14
uniprot id: A0A4X1SGR6
uniprot id: A0A4X1SH99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:ME1
gene id: 9823:ME1
uniprot id: A0A4X1V1B8
uniprot id: A0A5G2RAJ8
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9823:FOXL2
gene id: 9823:FOXL2
uniprot id: A0A480Z083
uniprot id: Q6VFT6
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ESR1. Interacts with UBE2I/UBC9. Interacts with SMAD3. Interacts with DDX20.
messages: Nucleus
messages: Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.
messages: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination (By similarity). Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells (By similarity). Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Activates SIRT1 transcription under cellular stress conditions (By similarity). Activates transcription of OSR2 (By similarity). Is a regulator of CYP19 expression (By similarity). Is a transcriptional repressor of STAR (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity).

9823:CUEDC2
gene id: 9823:CUEDC2
uniprot id: A0A286ZXC4
uniprot id: A0A8D2A2Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9823:RAMP1
gene id: 9823:RAMP1
uniprot id: Q867C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAMP family.
messages: Heterodimer of CALCRL and RAMP1.
messages: Membrane
messages: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL (By similarity).

9823:DUSP4
gene id: 9823:DUSP4
uniprot id: A0A4X1VTP4
uniprot id: F1RX60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9823:DTNBP1
gene id: 9823:DTNBP1
uniprot id: A0A4X1VR02
uniprot id: A5A770
names: Similarity
messages: Belongs to the dysbindin family.

9823:MAATS1
gene id: 9823:MAATS1
uniprot id: A0A8D1P7J1
uniprot id: F1SPB5
names: Similarity
messages: Belongs to the CFAP91 family.

9823:GC
gene id: 9823:GC
uniprot id: A0A4X1T9I2
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9823:DMD
gene id: 9823:DMD
uniprot id: Q5GN48
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.
messages: In the retina, expressed in the outer plexiform layer (OPL) and around the blood vessels. Also observed at the vitreal border of the retina corresponding to the inner limiting membrane (ILM). Presynaptically localized in cone pedicles and postsynaptically in bipolar cells (at protein level).
messages: Interacts with SYNM (By similarity). Interacts with the syntrophins SNTG1 and SNTG2. Interacts with KRT19. Component of the dystrophin-associated glycoprotein complex which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts with DAG1 (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif of DAG1 (By similarity). Interacts with SYNM; SNTA1 and SNTB1. Interacts with CMYA5. Directly interacts with ANK2 and ANK3; these interactions do not interfere with betaDAG1-binding and are necessary for proper localization in muscle cells. Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (By similarity). Interacts with DTNB (By similarity). Interacts with PGM5; the interaction is direct (By similarity). Interacts with NOS1; localizes NOS1 to sarcolemma in muscle cells (By similarity).
messages: Postsynaptic cell membrane
messages: cytoskeleton
messages: sarcolemma

9823:TMEM126B
gene id: 9823:TMEM126B
uniprot id: A0A480WQG8
uniprot id: A0A8D0ZD71
names: Subcellular Location Annotation
messages: Membrane

9823:COMP
gene id: 9823:COMP
uniprot id: A0A8D1U7D8
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:C7H15orf40
gene id: 9823:C7H15orf40
uniprot id: A0A8D0IZB8
uniprot id: F1RIB1
names: Similarity
messages: Belongs to the UPF0235 family.

9823:NQO1
gene id: 9823:NQO1
uniprot id: A0A8D0UV43
uniprot id: F1S395
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9823:CRAT
gene id: 9823:CRAT
uniprot id: A0A8D1QS88
uniprot id: A9JPD4
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9823:ACTN4
gene id: 9823:ACTN4
uniprot id: A0A287A4Q7
uniprot id: A0A287BAZ5
uniprot id: A0A480HSJ4
uniprot id: A0A4X1T1N2
uniprot id: A0A4X1T3R1
uniprot id: A0A8D0SN05
uniprot id: A0A8D0XA68
uniprot id: A0A8D1XWF6
uniprot id: F1RI39
names: Similarity
messages: Belongs to the alpha-actinin family.

9823:FZD5
gene id: 9823:FZD5
uniprot id: A0A8D0WIM6
uniprot id: F1SSU5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:SMARCD1
gene id: 9823:SMARCD1
uniprot id: A0A4X1WCH9
names: Similarity
messages: Belongs to the SMARCD family.

9823:RYR1
gene id: 9823:RYR1
uniprot id: Q29105
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9823:MAPK10
gene id: 9823:MAPK10
uniprot id: A0A4X1U0H3
uniprot id: A0A8D0WKS3
uniprot id: A0A8D1H850
uniprot id: A0A8D1K3D7
uniprot id: A0A8W4FNC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9823:EDNRB
gene id: 9823:EDNRB
uniprot id: P35463
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
messages: Cell membrane
messages: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9823:CLUAP1
gene id: 9823:CLUAP1
uniprot id: A0A480TL40
uniprot id: A0A4X1VT63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9823:TRAK1
gene id: 9823:TRAK1
uniprot id: A0A287APB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9823:SIAH1
gene id: 9823:SIAH1
uniprot id: A0A286ZUL1
uniprot id: A0A4X1TX37
uniprot id: A0A8D1CUM9
uniprot id: A0A8D1EFU7
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9823:FAM133B
gene id: 9823:FAM133B
uniprot id: A0A480JGJ3
uniprot id: A0A4X1U0P4
names: Similarity
messages: Belongs to the FAM133 family.

9823:TMEM63A
gene id: 9823:TMEM63A
uniprot id: A0A8D1JAS5
uniprot id: A0A8D1QMV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9823:ELOVL1
gene id: 9823:ELOVL1
uniprot id: A0A287AJA7
uniprot id: A0A8D0WFJ7
uniprot id: D0G6S6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:ZNF202
gene id: 9823:ZNF202
uniprot id: A0A4X1VHT3
uniprot id: A0A8D0LEP6
names: Subcellular Location Annotation
messages: Nucleus

9823:TMEM205
gene id: 9823:TMEM205
uniprot id: A0A287BCE5
uniprot id: A0A8D0M4C2
uniprot id: A0A8D1BLL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9823:MT1A
gene id: 9823:MT1A
uniprot id: P49068
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
messages: Monomer.

9823:F13A1
gene id: 9823:F13A1
uniprot id: A0A8D0ZUY7
uniprot id: K7GQL2
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9823:LOC100519871
gene id: 9823:LOC100519871
uniprot id: A0A8D0W9W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9823:SEC11C
gene id: 9823:SEC11C
uniprot id: A0A481CTH0
uniprot id: A0A4X1TPZ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:PDK1
gene id: 9823:PDK1
uniprot id: A0A8D1EH84
uniprot id: F1S069
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9823:BMP2
gene id: 9823:BMP2
uniprot id: A0A286ZZE2
uniprot id: A0A4X1UEL6
uniprot id: E1AXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9823:TTYH1
gene id: 9823:TTYH1
uniprot id: A0A5K1UQJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9823:LOC396867
gene id: 9823:LOC396867
uniprot id: Q28987
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Cytoplasm
messages: This is an intracellular thiol proteinase inhibitor.

9823:FYN
gene id: 9823:FYN
uniprot id: A1Y2K1
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated at Tyr-420 (By similarity). Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in an inactive state. PTPRC/CD45 dephosphorylates Tyr-531 leading to activation. Ultraviolet B (UVB) strongly increase phosphorylation at Thr-12 and kinase activity, and promotes translocation from the cytoplasm to the nucleus. Dephosphorylation at Tyr-420 by PTPN2 negatively regulates T-cell receptor signaling (By similarity). Phosphorylated at tyrosine residues, which can be enhanced by NTN1 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.
messages: Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB1, PAG1, and SH2D1A. Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway. Interacts with UNC119. Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity). Interacts with PTPRO (phosphorylated form) (By similarity). Interacts with PTPRB (phosphorylated form) (By similarity). Interacts with FYB2 (By similarity). Interacts with DSCAM (By similarity). Interacts with SKAP1 and FYB1; this interaction promotes the phosphorylation of CLNK (By similarity). Interacts with NEDD9; in the presence of PTK2 (By similarity).
messages: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By simi…
messages: Nucleus
messages: Palmitoylated. Palmitoylation at Cys-3 and Cys-6, probably by ZDHHC21, regulates subcellular location.
messages: Perikaryon

9823:GABRQ
gene id: 9823:GABRQ
uniprot id: A0A480DH03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:C2H19orf70
gene id: 9823:C2H19orf70
uniprot id: A1XQR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, MICOS13/MIC13, APOOL/MIC27 and IMMT/MIC60. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex.
messages: Mitochondrion inner membrane

9823:UTP15
gene id: 9823:UTP15
uniprot id: A0A480QFB6
uniprot id: A0A8D0IJX6
names: Subcellular Location Annotation
messages: nucleolus

9823:PLA2G5
gene id: 9823:PLA2G5
uniprot id: A0A286ZX54
uniprot id: A0A4X1W493
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9823:ARL4C
gene id: 9823:ARL4C
uniprot id: A0A8D1I8T7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9823:FERMT3
gene id: 9823:FERMT3
uniprot id: A0A480K0R6
uniprot id: A0A4X1VGB7
names: Similarity
messages: Belongs to the kindlin family.

9823:BMP6
gene id: 9823:BMP6
uniprot id: D0VFJ0
names: Similarity
messages: Belongs to the TGF-beta family.

9823:ANTXRL
gene id: 9823:ANTXRL
uniprot id: A0A4X1VH41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9823:LOC100516001
gene id: 9823:LOC100516001
uniprot id: A0A8D0UMS6
uniprot id: F1RFM2
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9823:GATA2
gene id: 9823:GATA2
uniprot id: A0A8D1BUN5
uniprot id: Q865U9
names: Subcellular Location Annotation
messages: Nucleus

9823:C6H18orf21
gene id: 9823:C6H18orf21
uniprot id: A0A481BD10
uniprot id: A0A4X1VD73
names: Similarity
messages: Belongs to the UPF0711 family.

9823:LOC100737983
gene id: 9823:LOC100737983
uniprot id: A0A4X1W7L0
uniprot id: F1SFB2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ACRBP
gene id: 9823:ACRBP
uniprot id: A0A480WSQ6
uniprot id: Q29016
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome (PubMed:8144514). Involved also in the acrosome formation (By similarity).
messages: Binds specifically to the 55- and 53-kDa proacrosins and the 49-kDa acrosin intermediate, but is not capable of binding 43-kDa acrosin intermediate and 32-kDa mature acrosin.
messages: Phosphorylated on Tyr residues in capacitated sperm.
messages: Secreted
messages: Specifically expressed in testis.
messages: Synthesized as a 60-kDa precursor, the 35-kDa mature form is post-translationally produced by the removal of the N-terminal half of the precursor during sperm maturation in the testis and/or epididymis.
messages: The N-terminus is blocked.
messages: acrosome

9823:NR2E1
gene id: 9823:NR2E1
uniprot id: A0A8D1KG40
uniprot id: I3LU21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:CLCN6
gene id: 9823:CLCN6
uniprot id: A0A481AIE6
uniprot id: A0A4X1W2C6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:CHFR
gene id: 9823:CHFR
uniprot id: A0A8D0WIN6
uniprot id: A0A8D0ZK93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHFR family.
messages: PML body

9823:LPAR2
gene id: 9823:LPAR2
uniprot id: A0A286ZX94
uniprot id: A0A4X1U1Q6
uniprot id: C5G5X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:DEFB123
gene id: 9823:DEFB123
uniprot id: A0A4X1SP61
uniprot id: A0A8D0SQ22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:PIGB
gene id: 9823:PIGB
uniprot id: A0A286ZQB9
uniprot id: A0A8D0W191
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:ECHS1
gene id: 9823:ECHS1
uniprot id: A0A480JRE1
uniprot id: A0A4X1V758
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9823:NDUFB8
gene id: 9823:NDUFB8
uniprot id: B8Y651
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:HCN3
gene id: 9823:HCN3
uniprot id: A0A480MSV7
uniprot id: A0A4X1VZD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9823:GAS8
gene id: 9823:GAS8
uniprot id: A0A481CAM7
uniprot id: A0A4X1TEQ1
uniprot id: A0A8D0YDR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum
messages: flagellum axoneme

9823:MRM1
gene id: 9823:MRM1
uniprot id: A0A5G2R9B5
uniprot id: A0A8D1G5U2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

9823:HOXA9
gene id: 9823:HOXA9
uniprot id: A0A4X1TU47
uniprot id: F1SHT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9823:C3H16orf71
gene id: 9823:C3H16orf71
uniprot id: F1RK72
names: Function
names: Subcellular Location Annotation
messages: Dynein axonemal particle
messages: In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.

9823:BIRC5
gene id: 9823:BIRC5
uniprot id: Q9GLN5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-129 results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.
messages: Belongs to the IAP family.
messages: Chromosome
messages: Cytoplasm
messages: In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities. Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity. Phosphorylation at Ser-20 by AURKC is critical for regulation of proper chromosome alignment and segregation, and possibly cytokinesis.
messages: Midbody
messages: Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8. Interacts with JTB. Interacts (via BIR domain) with histone H3 phosphorylated at 'Thr-3' (H3pT3). Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce. Interacts with FBXL7; this interaction facilitates the polyubiquitination and subsequent proteasomal degradation of BIRC5 by the SCF(FBXL7) E3 ubiquitin-protein ligase complex (By similarity).
messages: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity).
messages: Nucleus
messages: The BIR repeat is necessary and sufficient for LAMTOR5 binding.
messages: Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting. Deubiquitinated by USP35 or USP38; leading to stabilization.
messages: centromere
messages: kinetochore
messages: spindle

9823:CDC42
gene id: 9823:CDC42
uniprot id: A0A4X1W0S5
uniprot id: F2Z5W2
uniprot id: Q007T2
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with activated CSPG4 and with BAIAP2. Interacts with DOCK11/Zizimin2; the interaction activates CDC42 by exchanging GDP for GTP. Interacts with DOCK9; the interaction activates CDC42 by exchanging GDP for GTP. Interacts with DOCK8 (via DHR-2 domain); the interaction activates CDC42 by exchanging GDP for GTP. Interacts with IQGAP1. Interacts with NET1 and ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. The GTP-bound form interacts with CCPG1. Interacts with USP6. Interacts with NEK6. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with ITGB1BP1. Interacts with ARHGDIA; this interaction inactivates and stabilizes CDC42. Interacts with ARHGDIB; this maintains CDC42 in the inactive, GDP-bound form. Interacts in (GTP-bound form) with FNBP1L and ABI1, but only in the presence of FNBP1L.
messages: Membrane
messages: Midbody
messages: Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation inhibitor RhoGDI.
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity).
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
messages: centrosome
messages: dendrite
messages: lamellipodium membrane
messages: spindle

9823:CCL4
gene id: 9823:CCL4
uniprot id: B0FYJ9
uniprot id: Q711P4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Homodimer. Interacts with CCR5 (By similarity).
messages: Monokine with inflammatory and chemokinetic properties.
messages: Secreted

9823:AHCYL1
gene id: 9823:AHCYL1
uniprot id: A0A4X1TEF2
uniprot id: E7EI18
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

9823:UQCC
gene id: 9823:UQCC
uniprot id: A0A8D1ZA96
uniprot id: D3K5L2
names: Similarity
messages: Belongs to the CBP3 family.

9823:MT-2B
gene id: 9823:MT-2B
uniprot id: P79379
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Interacts with EOLA1.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

9823:TAMM41
gene id: 9823:TAMM41
uniprot id: A0A4X1UGZ8
uniprot id: A0A8D0QDG4
uniprot id: A0A8D1CB62
uniprot id: F1SQA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9823:NDUFB4
gene id: 9823:NDUFB4
uniprot id: A0A4X1T6M0
uniprot id: A0A8D1I4J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:IGFBP3
gene id: 9823:IGFBP3
uniprot id: P16611
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis (By similarity).
messages: Interacts with XLKD1. Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with TMEM219 (By similarity).
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Secreted

9823:PFDN1
gene id: 9823:PFDN1
uniprot id: A0A287BED1
uniprot id: A0A4X1SDR8
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9823:KARS
gene id: 9823:KARS
uniprot id: A0A287AKI9
uniprot id: A0A8D1ID99
uniprot id: F1S458
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9823:TCP1
gene id: 9823:TCP1
uniprot id: A0A8D1SZI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: centrosome

9823:SLC8A3
gene id: 9823:SLC8A3
uniprot id: A0A287A5R3
uniprot id: A0A287BCG8
uniprot id: A0A4X1TYI8
uniprot id: A0A4X1TYK9
uniprot id: A0A4X1U198
uniprot id: A0A4X1U456
uniprot id: F1S4A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9823:MGST1
gene id: 9823:MGST1
uniprot id: P79382
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAPEG family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Endoplasmic reticulum membrane
messages: Homotrimer; The trimer binds only one molecule of glutathione.
messages: Mitochondrion outer membrane

9823:NDUFAF7
gene id: 9823:NDUFAF7
uniprot id: A0A4X1T425
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

9823:HS3ST3B1
gene id: 9823:HS3ST3B1
uniprot id: A0A8D0RV86
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:LOC100737030
gene id: 9823:LOC100737030
uniprot id: A0A287AHM5
uniprot id: A0A4X1U9C9
names: Similarity
messages: Belongs to the intermediate filament family.

9823:SERINC5
gene id: 9823:SERINC5
uniprot id: A0A4X1T661
uniprot id: A0A8D1RS67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9823:LOC100514797
gene id: 9823:LOC100514797
uniprot id: A0A5G2R066
uniprot id: A0A8D1TQZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MEP1A
gene id: 9823:MEP1A
uniprot id: A0A480PSH0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:SSTR2
gene id: 9823:SSTR2
uniprot id: A0A480ZK14
uniprot id: P34994
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain) (By similarity).
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity).
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization (By similarity).
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9823:USP37
gene id: 9823:USP37
uniprot id: A0A480TJS3
uniprot id: A0A8D0JIU5
uniprot id: A0A8D0WHR0
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:TYRP1
gene id: 9823:TYRP1
uniprot id: A0A4X1WAF7
uniprot id: F6Q7U8
uniprot id: Q4R1H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9823:LOC100739644
gene id: 9823:LOC100739644
uniprot id: A0A8D0RMW4
uniprot id: A0A8D1KX76
names: Subcellular Location Annotation
messages: Secreted

9823:STAM2
gene id: 9823:STAM2
uniprot id: A0A4X1SUT4
uniprot id: F1SHW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9823:SNAP91
gene id: 9823:SNAP91
uniprot id: A0A4X1V5R8
uniprot id: A0A8D0IND4
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9823:DONSON
gene id: 9823:DONSON
uniprot id: A0A287BJG1
uniprot id: A0A4X1TZ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

9823:TTYH2
gene id: 9823:TTYH2
uniprot id: A0A287BMC9
uniprot id: A0A480XSM7
uniprot id: A0A8D0XYH2
uniprot id: A0A8D0Y1C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9823:FLOT1
gene id: 9823:FLOT1
uniprot id: A0A480IKJ2
uniprot id: A0A8D0N671
uniprot id: Q767L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Melanosome
messages: Membrane
messages: Membrane raft
messages: caveola

9823:DDX28
gene id: 9823:DDX28
uniprot id: A0A4X1UGF4
uniprot id: I3LB32
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9823:C1GALT1
gene id: 9823:C1GALT1
uniprot id: A0A8D0J401
uniprot id: A0A8D1ZA71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Membrane

9823:RELL2
gene id: 9823:RELL2
uniprot id: A0A8D0JDM0
uniprot id: A0A8D0JKZ1
names: Similarity
messages: Belongs to the RELT family.

9823:FOLR2
gene id: 9823:FOLR2
uniprot id: A0A287BJS7
uniprot id: A0A8D0PZ86
uniprot id: A0A8D0W485
uniprot id: P79388
names: Similarity
messages: Belongs to the folate receptor family.

9823:PNPLA4
gene id: 9823:PNPLA4
uniprot id: A0A8D1B072
uniprot id: A0A8D1J1J3
uniprot id: A0A8D1U918
uniprot id: C1KJN1
uniprot id: F1SG26
uniprot id: I3LD73
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:RBM15
gene id: 9823:RBM15
uniprot id: A0A4X1TC88
uniprot id: F1S619
names: Similarity
messages: Belongs to the RRM Spen family.

9823:LOC100152475
gene id: 9823:LOC100152475
uniprot id: A0A4X1ULM2
uniprot id: A0A8D1JTY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ISL1
gene id: 9823:ISL1
uniprot id: A0A4X1SR51
uniprot id: F1SMF7
names: Subcellular Location Annotation
messages: Nucleus

9823:SSRP1
gene id: 9823:SSRP1
uniprot id: A0A4X1VPY1
uniprot id: A0A8D0IFL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

9823:LHX1
gene id: 9823:LHX1
uniprot id: A0A8D1AEC3
uniprot id: F2Z531
names: Subcellular Location Annotation
messages: Nucleus

9823:PFN1
gene id: 9823:PFN1
uniprot id: A0A4X1UWL6
uniprot id: A0A8D0JTL8
names: Similarity
messages: Belongs to the profilin family.

9823:PDE1B
gene id: 9823:PDE1B
uniprot id: A0A8D1YEF5
uniprot id: I3LNW1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9823:ITGB6
gene id: 9823:ITGB6
uniprot id: Q1RPR6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Heterodimer of an alpha and a beta subunit (By similarity). Interacts with FLNB. Interacts with HAX1. ITGAV:ITGB6 interacts with FBN1 (By similarity). ITGAV:ITGB6 interacts with TGFB1 (By similarity).
messages: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity).
messages: The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.
messages: focal adhesion

9823:RAB33A
gene id: 9823:RAB33A
uniprot id: A0A8D1JY37
uniprot id: Q06AU8
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9823:CNOT6
gene id: 9823:CNOT6
uniprot id: A0A8D0Q4J7
uniprot id: A0A8D0SG00
uniprot id: A0A8D0SI12
uniprot id: A0A8D1CLJ2
uniprot id: A0A8D1XGJ1
uniprot id: F1S5Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9823:A1CF
gene id: 9823:A1CF
uniprot id: A0A287A5G9
names: Subcellular Location Annotation
messages: Cytoplasm

9823:LOC100525239
gene id: 9823:LOC100525239
uniprot id: F1RJD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SULT1A3
gene id: 9823:SULT1A3
uniprot id: Q6Y0X5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:SFRP4
gene id: 9823:SFRP4
uniprot id: A0A8D1HQM2
uniprot id: B2DCZ8
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:MAPK14
gene id: 9823:MAPK14
uniprot id: A0A287BHS8
uniprot id: A0A4X1SVG2
uniprot id: A0A4X1SWQ7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9823:TMEM254
gene id: 9823:TMEM254
uniprot id: A0A8D1AQQ8
names: Subcellular Location Annotation
messages: Membrane

9823:MDFI
gene id: 9823:MDFI
uniprot id: A0A480V2U7
uniprot id: A0A4X1SJK1
uniprot id: A0A8D0XX84
uniprot id: A0A8D1FIL7
uniprot id: A0A8D1VU81
names: Similarity
messages: Belongs to the MDFI family.

9823:DDX6
gene id: 9823:DDX6
uniprot id: A0A287AZJ4
uniprot id: A0A4X1SLL7
uniprot id: A0A4X1SMT0
uniprot id: F1SAJ5
names: Similarity
messages: Belongs to the DEAD box helicase family.

9823:SLC6A14
gene id: 9823:SLC6A14
uniprot id: A0A4X1W4T9
uniprot id: A0A8D1Z7Z3
uniprot id: C8CBZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9823:BEX1
gene id: 9823:BEX1
uniprot id: A0A4X1V0M4
uniprot id: F1RYE5
names: Similarity
messages: Belongs to the BEX family.

9823:CCL5
gene id: 9823:CCL5
uniprot id: A0A4X1T3A0
uniprot id: Q2EN89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:C1H6orf120
gene id: 9823:C1H6orf120
uniprot id: A0A4X1VX98
uniprot id: I3LL77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
messages: Secreted

9823:LOC100523887
gene id: 9823:LOC100523887
uniprot id: A0A5G2QBN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:STUM
gene id: 9823:STUM
uniprot id: A0A4X1TDT0
uniprot id: A0A4X1TEL7
names: Subcellular Location Annotation
messages: Membrane

9823:NAT9
gene id: 9823:NAT9
uniprot id: A0A4X1SI52
uniprot id: A0A8D1JFE0
uniprot id: A0A8D1RP55
uniprot id: A0A8W4F8U4
uniprot id: D3K5K7
uniprot id: F1RV66
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

9823:HTRA3
gene id: 9823:HTRA3
uniprot id: D3K5L5
names: Similarity
messages: Belongs to the peptidase S1C family.

9823:PLP2
gene id: 9823:PLP2
uniprot id: A0A4X1SYJ3
uniprot id: F1RW43
names: Subcellular Location Annotation
messages: Membrane

9823:SGK1
gene id: 9823:SGK1
uniprot id: A0A4X1VG12
uniprot id: A0A8D0QQD5
uniprot id: A0A8D1L2C2
uniprot id: A0A8D1NS28
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:FAM19A4
gene id: 9823:FAM19A4
uniprot id: A0A287B8Y1
uniprot id: A0A8D0J7I3
names: Similarity
messages: Belongs to the TAFA family.

9823:PRKRIP1
gene id: 9823:PRKRIP1
uniprot id: A0A5G2QNT3
uniprot id: A0A8D0T7D2
names: Similarity
messages: Belongs to the PRKRIP1 family.

9823:NSUN2
gene id: 9823:NSUN2
uniprot id: A0A480N382
uniprot id: A0A480V5Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

9823:PITHD1
gene id: 9823:PITHD1
uniprot id: A0A4X1VZ34
uniprot id: I3L9H4
names: Similarity
messages: Belongs to the PITHD1 family.

9823:TMEM14A
gene id: 9823:TMEM14A
uniprot id: A0A480JHW3
uniprot id: P56984
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM14 family.
messages: Endoplasmic reticulum membrane
messages: Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
messages: Mitochondrion membrane

9823:FAM214B
gene id: 9823:FAM214B
uniprot id: A0A8D1PK46
uniprot id: F1SIH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

9823:SLA-DQA1
gene id: 9823:SLA-DQA1
uniprot id: Q6JHY7
uniprot id: Q7YQ90
names: Similarity
messages: Belongs to the MHC class II family.

9823:EVX1
gene id: 9823:EVX1
uniprot id: A0A4X1TSU9
uniprot id: F1SHT9
names: Subcellular Location Annotation
messages: Nucleus

9823:DYNC1LI2
gene id: 9823:DYNC1LI2
uniprot id: A0A287BSZ9
uniprot id: A0A8D0X6Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9823:PYGL
gene id: 9823:PYGL
uniprot id: B1A8Z3
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9823:CUL4A
gene id: 9823:CUL4A
uniprot id: A0A480LCF6
uniprot id: A0A4X1U051
names: Similarity
messages: Belongs to the cullin family.

9823:ERGIC1
gene id: 9823:ERGIC1
uniprot id: A0A8D1MNR8
uniprot id: F1SJY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9823:TPPP2
gene id: 9823:TPPP2
uniprot id: A0A4X1UXK8
uniprot id: A0A8D0QLY7
names: Similarity
messages: Belongs to the TPPP family.

9823:PUSL1
gene id: 9823:PUSL1
uniprot id: A0A8D0VSL6
uniprot id: A0A8D1UHR8
uniprot id: F1RJE9
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9823:LOC100624524
gene id: 9823:LOC100624524
uniprot id: A0A5G2R151
uniprot id: A0A8D1AUG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FTO
gene id: 9823:FTO
uniprot id: A9LN07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fto family.
messages: Cytoplasm
messages: Nucleus speckle

9823:SLC12A4
gene id: 9823:SLC12A4
uniprot id: A0A4X1UI23
uniprot id: O18887
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9823:RAB3A
gene id: 9823:RAB3A
uniprot id: Q06AU3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Interacts with RIMS1 and RIMS2 (By similarity). Interacts with Rabphilin-3A/RPH3A and Rab effector Noc2/RPH3AL (By similarity). Interacts with SYTL4 (By similarity). Interacts with RAB3IP (By similarity). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with SYT1 (By similarity). Interacts with MYH9; this interaction is essential for lysosome exocytosis and plasma membrane repair (By similarity). Interacts with STXBP1; this interaction promotes RAB3A dissociation from the vesicle membrane (By similarity). Interacts with SNCA (By similarity). Interacts with GDI1, GDI2, CHM and CHML; phosphorylation at Thr-86 disrupts these interactions (By similarity). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).
messages: Lysosome
messages: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Postsynapse
messages: Presynapse
messages: Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity). Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity).
messages: axon
messages: cytosol
messages: secretory vesicle

9823:LAMP1
gene id: 9823:LAMP1
uniprot id: A0A8D1DTS3
uniprot id: Q5K4G2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9823:SLC35A4
gene id: 9823:SLC35A4
uniprot id: Q8MIA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Found in a complex with SLC35A2 and SLC35A3.
messages: Golgi apparatus membrane
messages: Mediates the transport of CDP-ribitol (By similarity). Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity (By similarity).

9823:ADAT2
gene id: 9823:ADAT2
uniprot id: A0A287ATE6
uniprot id: A0A4X1VMQ7
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9823:NARFL
gene id: 9823:NARFL
uniprot id: A0A4X1SX73
uniprot id: A0A8D1U0T3
names: Similarity
messages: Belongs to the NARF family.

9823:HYAL2
gene id: 9823:HYAL2
uniprot id: A0A4X1SK14
uniprot id: A0A5K1TZ96
uniprot id: Q6RHW3
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9823:ASF1B
gene id: 9823:ASF1B
uniprot id: A0A8D1P8G9
uniprot id: B6DX84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9823:PRLR
gene id: 9823:PRLR
uniprot id: A0A8D0ZCE3
uniprot id: Q6JTA8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9823:PIK3R5
gene id: 9823:PIK3R5
uniprot id: O02696
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Greatly activated by G gamma proteins.
messages: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers.
messages: Nucleus
messages: Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.
messages: The heterodimerization region allows the binding to the catalytic subunit.

9823:SLC5A6
gene id: 9823:SLC5A6
uniprot id: A0A8D1D4I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9823:BCL2A1
gene id: 9823:BCL2A1
uniprot id: A0A8D1SE13
uniprot id: C7F841
names: Similarity
messages: Belongs to the Bcl-2 family.

9823:TEX261
gene id: 9823:TEX261
uniprot id: A0A4X1W993
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9823:CLDN4
gene id: 9823:CLDN4
uniprot id: A0A8D1YZR5
uniprot id: C3VML0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:BCAN
gene id: 9823:BCAN
uniprot id: A0A8D0QRR0
uniprot id: F1RP38
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:IRF4
gene id: 9823:IRF4
uniprot id: A0MZ86
names: Subcellular Location Annotation
messages: Nucleus

9823:MFSD14B
gene id: 9823:MFSD14B
uniprot id: A0A4X1U4Y8
uniprot id: I3LSQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9823:ITM2C
gene id: 9823:ITM2C
uniprot id: Q06AV4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITM2 family.
messages: Cell membrane
messages: Interacts with BACE1. Interacts with APP. Interacts with STMN2 (By similarity).
messages: Lysosome membrane
messages: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
messages: Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B (By similarity).

9823:ITPKC
gene id: 9823:ITPKC
uniprot id: A0A8D1ZQL3
uniprot id: F1RHA5
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9823:NAGA
gene id: 9823:NAGA
uniprot id: B1PK16
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9823:LOC100522551
gene id: 9823:LOC100522551
uniprot id: A0A8D1L275
uniprot id: F1S454
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9823:SLC29A2
gene id: 9823:SLC29A2
uniprot id: A0A5G2R8E6
uniprot id: A0A8D1AMS7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

9823:RPSA
gene id: 9823:RPSA
uniprot id: A0A480SME4
uniprot id: Q4GWZ2
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9823:NMUR2
gene id: 9823:NMUR2
uniprot id: A0A060ILH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9823:DMAP1
gene id: 9823:DMAP1
uniprot id: A0A287B017
uniprot id: A0A4X1W961
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100514309
gene id: 9823:LOC100514309
uniprot id: A0A4X1VIF5
uniprot id: A0A8W4FI21
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:C1H15orf65
gene id: 9823:C1H15orf65
uniprot id: A0A287AA69
uniprot id: A0A4X1TH04
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9823:HSPB6
gene id: 9823:HSPB6
uniprot id: A0A287AQR8
uniprot id: A0A4X1TIY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Nucleus

9823:CDC45
gene id: 9823:CDC45
uniprot id: A0A480WYQ3
uniprot id: A0A4X1UT27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9823:THRSP
gene id: 9823:THRSP
uniprot id: A0A286ZQX5
uniprot id: A0A8D0Z2C1
uniprot id: F8UX46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9823:TBCB
gene id: 9823:TBCB
uniprot id: A0A8D1JEU4
uniprot id: Q8HXL4
names: Similarity
messages: Belongs to the TBCB family.

9823:ATPIF1
gene id: 9823:ATPIF1
uniprot id: Q29307
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase (By similarity). Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme (By similarity).
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil composed of residues 74-106, leaving each N-terminal inhibitory region (residues 26-52) accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region (residues 26-52) binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity (By similarity).
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0 (By similarity).
messages: Mitochondrion

9823:PIN4
gene id: 9823:PIN4
uniprot id: A0A4X1W136
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

9823:PPIC
gene id: 9823:PPIC
uniprot id: A0A287AEA2
uniprot id: A0A4X1UDH8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9823:SBDS
gene id: 9823:SBDS
uniprot id: A0A4X1SWU2
uniprot id: F1RJJ3
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9823:RIBC1
gene id: 9823:RIBC1
uniprot id: A0A5G2R4Y0
uniprot id: A0A8D0YSQ9
names: Similarity
messages: Belongs to the RIB43A family.

9823:ACTL7A
gene id: 9823:ACTL7A
uniprot id: A0A8D0ZMQ0
uniprot id: A0A8D1FNL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

9823:ARG1
gene id: 9823:ARG1
uniprot id: A0A480QN87
uniprot id: Q95JC8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Homotrimer (By similarity). Interacts with CMTM6 (By similarity).

9823:FLNC
gene id: 9823:FLNC
uniprot id: A0A480S5Q0
uniprot id: A0A480U5F8
uniprot id: A0A8D0TZP9
uniprot id: A0A8D1F931
uniprot id: F1SMN5
names: Similarity
messages: Belongs to the filamin family.

9823:MAP4
gene id: 9823:MAP4
uniprot id: A0A8D0QTZ3
uniprot id: A0A8D1XAI2
uniprot id: F1SLI3
names: Subcellular Location Annotation
messages: cytoskeleton

9823:OLFM2
gene id: 9823:OLFM2
uniprot id: I3L7A4
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9823:MAB21L1
gene id: 9823:MAB21L1
uniprot id: A0A8D0M948
uniprot id: A0A8D0ZIJ2
names: Similarity
messages: Belongs to the mab-21 family.

9823:MYO5C
gene id: 9823:MYO5C
uniprot id: A0A287ARB4
uniprot id: A0A8D0J3Q4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9823:HPS6
gene id: 9823:HPS6
uniprot id: A0A8D0TMT0
uniprot id: A5A775
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

9823:MAPRE1
gene id: 9823:MAPRE1
uniprot id: A0A4X1SZV0
uniprot id: A0A4X1T1C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9823:NPG1
gene id: 9823:NPG1
uniprot id: P32194
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.
messages: Secreted

9823:EXOSC3
gene id: 9823:EXOSC3
uniprot id: A0A8D0TA53
uniprot id: F1ST67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm
messages: nucleolus

9823:PIH1D3
gene id: 9823:PIH1D3
uniprot id: A0A8D0S7C3
uniprot id: A0A8D1B8D1
uniprot id: K7GNQ8
names: Similarity
messages: Belongs to the PIH1 family.

9823:NFIL3
gene id: 9823:NFIL3
uniprot id: A0A4X1SEN5
uniprot id: F1RN07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Homodimer. Binds DNA as a dimer.
messages: Nucleus

9823:SEC61G
gene id: 9823:SEC61G
uniprot id: A0A287B1B1
uniprot id: A0A8D0W158
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:DRAM1
gene id: 9823:DRAM1
uniprot id: A0A8D1RMI6
uniprot id: D7RA18
names: Subcellular Location Annotation
messages: Membrane

9823:UBE2D1
gene id: 9823:UBE2D1
uniprot id: A0A4X1VCP6
uniprot id: Q06AA8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:ARL14
gene id: 9823:ARL14
uniprot id: A0A8D1Q775
uniprot id: A0A8W4FJD5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9823:TSHB
gene id: 9823:TSHB
uniprot id: P01224
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Indispensable for the control of thyroid structure and metabolism.
messages: Secreted

9823:TMEM229B
gene id: 9823:TMEM229B
uniprot id: A0A4X1U8L5
uniprot id: A0A8D1IVP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9823:CA11
gene id: 9823:CA11
uniprot id: A0A480JGT2
uniprot id: A0A4X1W0M0
uniprot id: Q866X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.
messages: Secreted

9823:RPL5
gene id: 9823:RPL5
uniprot id: B0FWK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9823:MED10
gene id: 9823:MED10
uniprot id: A0A4X1TKI3
uniprot id: A0A8D1BGW3
uniprot id: A0A8W4F6T0
uniprot id: F1S049
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:LTF
gene id: 9823:LTF
uniprot id: P14632
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferrin family.
messages: Cytoplasmic granule
messages: Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity. Antimicrobial properties may include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. May have anabolic, differentiating and anti-apoptotic effects on osteoblasts and may also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. May interfere with the lipopolysaccharide (LPS)-stimulated TLR4 signaling (By similarity).
messages: Monomer. Found in a complex with LTF, CLU, EPPIN and SEMG1 (By similarity).
messages: Secreted
messages: The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites.
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.

9823:NR5A1
gene id: 9823:NR5A1
uniprot id: P79387
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation stimulates the transcriptional activity.
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Binds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with NR0B2, NCOA2 and PPARGC1A. Interacts with DGKQ and CDK7. Binds to and activated by HIPK3 (By similarity).
messages: Nucleus
messages: Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity).
messages: Sumoylation reduces CDK7-mediated phosphorylation on Ser-203.
messages: Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity).

9823:ATP6V0A1
gene id: 9823:ATP6V0A1
uniprot id: A0A287BC33
uniprot id: A0A480IX08
uniprot id: A0A4X1U3I6
uniprot id: A0A4X1U3K4
uniprot id: F1S1D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9823:KANSL2
gene id: 9823:KANSL2
uniprot id: A0A480XKJ0
uniprot id: A0A480XWY2
uniprot id: A0A4X1TB16
uniprot id: A0A8D0XWF5
uniprot id: A0A8D1MUD4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
messages: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
messages: Nucleus

9823:COPS6
gene id: 9823:COPS6
uniprot id: A0A480LKS3
uniprot id: A7TX81
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although related to the peptidase M67A family, it lacks the JAMM motif that probably constitutes the catalytic center and therefore it probably does not have a protease activity.
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Has some glucocorticoid receptor-responsive activity (By similarity). Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets, including SFN (By similarity).
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (By similarity). In the complex, it probably interacts directly with COPS2, COPS4, COPS5, COPS7 (COPS7A or COPS7B) and COPS9 (By similarity). Interacts with the translation initiation factor EIF3S6 (By similarity). Interacts weakly with RBX1 (By similarity). Directly interacts with COP1 and 14-3-3 protein sigma/SFN (By similarity). Interacts with ERCC6 (By similarity).
messages: Cytoplasm
messages: Nucleus

9823:SCARA5
gene id: 9823:SCARA5
uniprot id: A0A4X1VB74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9823:TDP1
gene id: 9823:TDP1
uniprot id: A0A5G2R3G8
uniprot id: A0A8D1CQS6
uniprot id: A0A8D2C8J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

9823:PRKD3
gene id: 9823:PRKD3
uniprot id: A0A4X1T2Y5
uniprot id: A0A4X1T3J1
uniprot id: A0A8D0MYE6
uniprot id: A0A8D1MR81
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9823:SLC35B4
gene id: 9823:SLC35B4
uniprot id: A0A8D1SHV0
uniprot id: A0A8W4FIJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9823:SLC15A4
gene id: 9823:SLC15A4
uniprot id: A0A4X1UL43
uniprot id: A0A8D1ZMG7
uniprot id: I3LDX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

9823:RPL10
gene id: 9823:RPL10
uniprot id: Q29195
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Citrullinated by PADI4.
messages: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
messages: Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
messages: Cytoplasm
messages: Ufmylated by UFL1.

9823:TRIM65
gene id: 9823:TRIM65
uniprot id: A0A4X1V0V0
uniprot id: F1RW04
names: Subcellular Location Annotation
messages: Cytoplasm

9823:SLC7A7
gene id: 9823:SLC7A7
uniprot id: A0A4X1V3S9
uniprot id: A8HG48
names: Subcellular Location Annotation
messages: Membrane

9823:RPL23A
gene id: 9823:RPL23A
uniprot id: A0A286ZL51
uniprot id: A0A4X1TPC2
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9823:DHRS7
gene id: 9823:DHRS7
uniprot id: A0A4X1W7G7
uniprot id: F1SSI2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:ALAS2
gene id: 9823:ALAS2
uniprot id: A0A481BET8
uniprot id: A0A4X1VBZ1
uniprot id: A0A4X1VC48
uniprot id: A0A8D0PNK7
uniprot id: F1RUD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9823:LOC100523171
gene id: 9823:LOC100523171
uniprot id: A0A287BB46
uniprot id: A0A4X1V2M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TBK1
gene id: 9823:TBK1
uniprot id: A0A4X1W422
uniprot id: A0A8D1J7T4
names: Subcellular Location Annotation
messages: Cytoplasm

9823:RIC3
gene id: 9823:RIC3
uniprot id: A0A8D0R739
uniprot id: A0A8D1W1N9
names: Similarity
messages: Belongs to the ric-3 family.

9823:GALT
gene id: 9823:GALT
uniprot id: A0A4X1UUG9
uniprot id: F1S3U0
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

9823:MED4
gene id: 9823:MED4
uniprot id: A0A286ZZ81
uniprot id: A0A8D2BUW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:DOHH
gene id: 9823:DOHH
uniprot id: A0A8D1T6S4
uniprot id: F1S8E6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

9823:IRAK1BP1
gene id: 9823:IRAK1BP1
uniprot id: A0A8D0ZZH1
uniprot id: F1RQK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

9823:PTGFR
gene id: 9823:PTGFR
uniprot id: A0A8D0MX71
uniprot id: Q95L06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:NUDT4
gene id: 9823:NUDT4
uniprot id: A0A287A8H7
uniprot id: A0A8D0M225
uniprot id: A0A8D1X0I3
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9823:LBX2
gene id: 9823:LBX2
uniprot id: A0A4X1W775
uniprot id: F1SNT2
names: Subcellular Location Annotation
messages: Nucleus

9823:CACNA2D1
gene id: 9823:CACNA2D1
uniprot id: A0A287AP40
uniprot id: A0A480T791
uniprot id: A0A4X1SKZ9
uniprot id: A0A4X1SL12
uniprot id: A0A8D0J0B3
uniprot id: A0A8D0ZLH1
uniprot id: O77773
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9823:ATM
gene id: 9823:ATM
uniprot id: Q6PQD5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and subsequent autophosphorylation on Ser-1982. Acetylated in vitro by KAT5/TIP60. Deacetylated by SIRT7 during the late stages of DNA damage response, promoting ATM dephosphorylation and subsequent deactivation.
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Cytoplasmic vesicle
messages: Homodimer (By similarity). Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active. Binds p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with RAD17; DNA damage promotes the association. Interacts with EEF1E1; the interaction, induced on DNA damage, up-regulates TP53. Interacts with DCLRE1C, KAT8, KAT5, NABP2, ATMIN and CEP164. Interacts with AP2B1 and AP3B2; the interaction occurs in cytoplasmic vesicles (By similarity). Interacts with TELO2 and TTI1. Interacts with DDX1. Interacts with BRAT1 (By similarity). Interacts with CYREN (via XLF motif) (By similarity). Interacts (via microbody targeting signal) with PEX5; promoting translocation to peroxisomes in response to reactive oxygen species (ROS) (By similarity).
messages: Inhibited by wortmannin.
messages: Nucleus
messages: Peroxisome matrix
messages: Phosphorylated by NUAK1/ARK5. Autophosphorylation on Ser-367, Ser-1894, Ser-1982 correlates with DNA damage-mediated activation of the kinase. During the late stages of DNA damage response, dephosphorylated following deacetylation by SIRT7, leading to ATM deactivation.
messages: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (By similarity). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (By similarity). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in re…
messages: The FATC domain is required for interaction with KAT5.
messages: centrosome

9823:NR1I3
gene id: 9823:NR1I3
uniprot id: A0A8D0I3K3
uniprot id: Q2V0W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:SLC39A4
gene id: 9823:SLC39A4
uniprot id: F1RSN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9823:CCDC86
gene id: 9823:CCDC86
uniprot id: A0A4X1VLW1
uniprot id: A0A8D0Y9K4
names: Subcellular Location Annotation
messages: Nucleus

9823:AZIN1
gene id: 9823:AZIN1
uniprot id: A0A8D2BKE3
uniprot id: B2ZDY9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9823:ATG4C
gene id: 9823:ATG4C
uniprot id: A0A8D0MSY4
uniprot id: D7RA23
uniprot id: F1S810
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9823:GTF2H1
gene id: 9823:GTF2H1
uniprot id: A0A4X1T9S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9823:NKX2-3
gene id: 9823:NKX2-3
uniprot id: A0A4X1U6N2
names: Subcellular Location Annotation
messages: Nucleus

9823:TMEM251
gene id: 9823:TMEM251
uniprot id: Q6QA74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LYSET family.
messages: Golgi apparatus membrane
messages: Interacts with GNPTAB; this interaction is important for proper localization of GNPTAB in Golgi stacks. Interacts with MBTPS1.
messages: Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases.

9823:USP30
gene id: 9823:USP30
uniprot id: A0A4X1STA2
uniprot id: A0A8D1B889
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:FGF13
gene id: 9823:FGF13
uniprot id: A0A4X1SHL0
uniprot id: I3LMC4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:ANXA2
gene id: 9823:ANXA2
uniprot id: A0A4X1TPP0
uniprot id: K7GKR6
uniprot id: P19620
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
messages: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with ATP1B1 (By similarity). Interacts with DYSF (By similarity). Interacts with COCH. Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR. Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1 (By similarity). Interacts with APPL2 and APPL1; targets APPL2 to endosomes and acting in parallel to RAB5A (By similarity). Interacts with S100A4 (By similarity). May interact with UBAP2 (By similarity).
messages: ISGylated.
messages: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
messages: Melanosome
messages: Membrane
messages: basement membrane

9823:CCL22
gene id: 9823:CCL22
uniprot id: G8XRI5
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9823:SLC5A4
gene id: 9823:SLC5A4
uniprot id: P31636
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Inhibited by phlorizin.
messages: Kidney, intestine, liver, skeletal muscle and spleen.
messages: Low-affinity sodium/D-glucose symporter with a great selectivity for sugars (D-glucose >> D-galactose) (PubMed:13130073, PubMed:8077195). Na(+) and D-glucose transport are tightly coupled at neutral pH, but at acidic pH, ion transport is uncoupled from sugar transport (PubMed:13130073, PubMed:8077195).
messages: Was originally thought to be a sodium/neutral amino acid cotransporter (system a neutral amino acid transporter) responsible for the sodium-dependent intake of neutral amino acids such as alanine, glycine, serine, cysteine, and proline.

9823:CCNH
gene id: 9823:CCNH
uniprot id: A0A480Q032
uniprot id: A0A4X1TCE5
uniprot id: A0A8D0X880
uniprot id: A0A8D1EU90
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9823:HEXA
gene id: 9823:HEXA
uniprot id: B1PK15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9823:PARP3
gene id: 9823:PARP3
uniprot id: A0A8D1BNC0
uniprot id: I3LJ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9823:LAMB1
gene id: 9823:LAMB1
uniprot id: A0A8D1XZJ0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9823:PEBP4
gene id: 9823:PEBP4
uniprot id: A0A4X1VFH2
uniprot id: C4TP28
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9823:TP53
gene id: 9823:TP53
uniprot id: A0A1B2TT48
uniprot id: Q9TUB2
names: Cofactor
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of Lys-375 by CREBBP enhances transcriptional activity. Acetylation of Lys-375 by EP300. Deacetylation of Lys-375 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner. Acetylation at Lys-374 increases stability. Deacetylation at Lys-374 by SIRT6 decreases its stability, thereby regulating cell senescence.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Forms homodimers and homotetramers (By similarity). Binds DNA as a homotetramer. Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity. Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-375) with L3MBTL1. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interactio…
messages: Mitochondrion matrix
messages: Monomethylated at Lys-365 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-363 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-365 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-363. Dimethylated at Lys-366 by EHMT1 and EHMT2. Monomethylated at Lys-375 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Demethylation of dimethylated Lys-363 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity). Monomethylated at Arg-326 and dimethylated at Arg-328 and Arg-330 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).
messages: Nucleus
messages: PML body
messages: Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated by HIPK1. Phosphorylated on Ser-385 following UV but not gamma irradiation. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-47, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-47 in response to genotoxic stress. Phosphorylated at Ser-308 and Ser-385 by CDK2 in response to DNA-damage (By similarity). Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (By similarity).
messages: Sumoylated with SUMO1. Sumoylated at Lys-379 by UBC9 (By similarity).
messages: The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
messages: Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation (By similarity). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity). Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation (By similarity).
messages: centrosome
messages: p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.

9823:XCR1
gene id: 9823:XCR1
uniprot id: A0A8D0Y1X9
uniprot id: Q75ZH8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:GAB1
gene id: 9823:GAB1
uniprot id: A0A480ZFM5
uniprot id: A0A8D1U4K7
names: Similarity
messages: Belongs to the GAB family.

9823:PSMC2
gene id: 9823:PSMC2
uniprot id: A0A4X1VCL1
uniprot id: A0A8D0VT21
names: Similarity
messages: Belongs to the AAA ATPase family.

9823:PPP1R9B
gene id: 9823:PPP1R9B
uniprot id: A0A480L9H7
uniprot id: A0A8D1IPX5
names: Subcellular Location Annotation
messages: cytoskeleton

9823:DYNC1I2
gene id: 9823:DYNC1I2
uniprot id: A0A4X1VH50
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9823:IL17RB
gene id: 9823:IL17RB
uniprot id: A0A287ACJ1
uniprot id: A0A4X1VKS3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:SF3B1
gene id: 9823:SF3B1
uniprot id: A0A286ZHW0
uniprot id: A0A8D0RX55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

9823:LOC100514282
gene id: 9823:LOC100514282
uniprot id: A0A286ZJ89
uniprot id: A0A4X1W6G6
names: Similarity
messages: Belongs to the PRORSD1 family.

9823:SH2B2
gene id: 9823:SH2B2
uniprot id: A0A4X1UK61
names: Similarity
messages: Belongs to the SH2B adapter family.

9823:GADD45G
gene id: 9823:GADD45G
uniprot id: A0A4X1SEY5
uniprot id: D3Y270
names: Similarity
messages: Belongs to the GADD45 family.

9823:ST3GAL3
gene id: 9823:ST3GAL3
uniprot id: A0A4X1W822
uniprot id: Q70D54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9823:RPS21
gene id: 9823:RPS21
uniprot id: P63221
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9823:AMPD3
gene id: 9823:AMPD3
uniprot id: A0A287BD33
uniprot id: A0A4X1TV15
uniprot id: A0A8D0W124
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9823:ANTXR1
gene id: 9823:ANTXR1
uniprot id: A0A8D1DNI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9823:AVIL
gene id: 9823:AVIL
uniprot id: A0A8D0YIU0
uniprot id: I3LI80
names: Similarity
messages: Belongs to the villin/gelsolin family.

9823:INHBA
gene id: 9823:INHBA
uniprot id: P03970
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity).
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9823:CCR3
gene id: 9823:CCR3
uniprot id: Q75ZH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:FBN1
gene id: 9823:FBN1
uniprot id: Q9TV36
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibrillin family.
messages: Cleavage of N- and C-terminus by furin is required for incorporation into the extracellular matrix and assembly into microfibrils. The C-terminus, which corresponds to the Asprosin chain, was initially thought to constitute a propeptide. Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin, an essential step for incorporation of Fibrillin-1 into the nascent microfibrils.
messages: Forms intermolecular disulfide bonds either with other fibrillin-1 molecules or with other components of the microfibrils.
messages: Hormone that targets the liver to increase plasma glucose levels. Secreted by white adipose tissue and circulates in the plasma. Acts in response to fasting and promotes blood glucose elevation by binding to the surface of hepatocytes. Promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation.
messages: Interacts with COL16A1. Interacts with integrin alpha-V/beta-3. Interacts with ADAMTS10; this interaction promotes microfibril assembly. Interacts with THSD4; this interaction promotes fibril formation. Interacts (via N-terminal domain) with FBLN2 and FBLN5. Interacts with ELN. Forms a ternary complex with ELN and FBLN2 or FBLN5 and a significant interaction with ELN seen only in the presence of FBLN2 or FBLN5. Interacts (via N-terminal domain) with LTBP2 (via C-terminal domain) in a Ca(+2)-dependent manner. Interacts (via N-terminal domain) with LTBP1 (via C-terminal domain). Interacts with integrins ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. Interacts (via N-terminal domain) with BMP2, BMP4, BMP7, BMP10 and GDF5. Interacts (via N-terminal domain) with MFAP2 and MFAP5. Interacts with ADAMTSL5. Interacts with MFAP4. Interacts (via N-terminal domain) with TNFSF11 in a Ca(+2)-dependent manner. Interacts (via N-terminal domain) with EFEMP2; this interaction inhibits EFEMP2 binding to LOX and ELN (By similarity).
messages: O-glycosylated on serine residues by POGLUT2 and POGLUT3 which is necessary for efficient protein secretion.
messages: Secreted
messages: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function. Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils.
messages: extracellular matrix

9823:GSS
gene id: 9823:GSS
uniprot id: A0A8D1TEU2
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9823:C15H2orf76
gene id: 9823:C15H2orf76
uniprot id: A0A8D0HPV6
names: Similarity
messages: Belongs to the UPF0538 family.

9823:NTN4
gene id: 9823:NTN4
uniprot id: F1SQR3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LPCAT1
gene id: 9823:LPCAT1
uniprot id: A0A4X1TM25
uniprot id: F1S029
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9823:LOC106504264
gene id: 9823:LOC106504264
uniprot id: A0A4X1SL23
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TSEN15
gene id: 9823:TSEN15
uniprot id: A0A8D1X8K8
names: Similarity
messages: Belongs to the SEN15 family.

9823:PGLYRP1
gene id: 9823:PGLYRP1
uniprot id: Q6PKY6
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

9823:ACP1
gene id: 9823:ACP1
uniprot id: A0A4X1UMF6
uniprot id: A0A8D0PYL8
uniprot id: P81693
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm
messages: Inhibited by sulfhydryl reagents.
messages: Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1. Interacts with the SH3 domain of SPTAN1.
messages: Phosphorylated by LCK. Phosphorylation at Tyr-132 increases its phosphatase activity.

9823:CCR7
gene id: 9823:CCR7
uniprot id: A0A8D1ML07
uniprot id: Q861S1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:CFLAR
gene id: 9823:CFLAR
uniprot id: A0A4X1VD43
uniprot id: A0A4X1VD48
uniprot id: Q6QN97
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:CDK9
gene id: 9823:CDK9
uniprot id: A0A8D1H4G0
uniprot id: C9E1C9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:MED12
gene id: 9823:MED12
uniprot id: A0A8X9AEI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

9823:LOC100525869
gene id: 9823:LOC100525869
uniprot id: A0A287AZF9
uniprot id: A0A4X1UNI7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Membrane
messages: Mitochondrion inner membrane

9823:CRISP1
gene id: 9823:CRISP1
uniprot id: A0A8D0S0L0
uniprot id: B2ZGN1
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DLAT
gene id: 9823:DLAT
uniprot id: Q95N04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9823:ADRA2A
gene id: 9823:ADRA2A
uniprot id: P18871
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Alpha2-adrenergic receptor shows an allosteric modulation by Na(+), H(+) and amiloride analogs.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
messages: Cell membrane
messages: It is uncertain whether Met-1 or Met-16 is the initiator.

9823:DDO
gene id: 9823:DDO
uniprot id: A3KCL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome
messages: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.

9823:CA6
gene id: 9823:CA6
uniprot id: A0A4X1W9S1
uniprot id: B7X727
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9823:PCLAF
gene id: 9823:PCLAF
uniprot id: A0A4X1TYD4
uniprot id: F1S0A4
names: Subcellular Location Annotation
messages: Nucleus
messages: perinuclear region

9823:LOC100517855
gene id: 9823:LOC100517855
uniprot id: A0A287ACH8
uniprot id: A0A4X1SMK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

9823:NXPH2
gene id: 9823:NXPH2
uniprot id: A0A287BFD3
uniprot id: A0A4X1SZQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9823:SPAM1
gene id: 9823:SPAM1
uniprot id: Q8MI02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9823:CAST
gene id: 9823:CAST
uniprot id: Q6Q781
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

9823:TMEM86B
gene id: 9823:TMEM86B
uniprot id: A0A8D0XJW7
uniprot id: F1RMN2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM86 family.
messages: Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen.
messages: Competitively inhibited by lysophosphatidic acid.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Membrane

9823:UTS2
gene id: 9823:UTS2
uniprot id: Q95J46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Highly potent vasoconstrictor.
messages: Secreted

9823:PARVG
gene id: 9823:PARVG
uniprot id: A0A8D0Z6S9
uniprot id: F1SJU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane

9823:ALG5
gene id: 9823:ALG5
uniprot id: A0A4X1T2U6
uniprot id: F1RS38
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9823:LSM6
gene id: 9823:LSM6
uniprot id: A0A8W4FJI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9823:SYS1
gene id: 9823:SYS1
uniprot id: A0A8D0PP51
uniprot id: F1SD37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9823:SMIM8
gene id: 9823:SMIM8
uniprot id: A0A4X1VLA3
uniprot id: A0A8D1L3F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9823:IFRD2
gene id: 9823:IFRD2
uniprot id: A0A480K124
uniprot id: A0A4X1SKJ2
names: Similarity
messages: Belongs to the IFRD family.

9823:ICOS
gene id: 9823:ICOS
uniprot id: A0A4X1V2P7
uniprot id: A0A8D1WQ52
uniprot id: Q2KMN0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9823:CPLX1
gene id: 9823:CPLX1
uniprot id: A0A8D0LSF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9823:CALR
gene id: 9823:CALR
uniprot id: P28491
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calreticulin family.
messages: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (PubMed:20222029). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity).
messages: Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity).
messages: Cell surface
messages: Cortical granule
messages: Cytolytic granule
messages: Endoplasmic reticulum lumen
messages: Expressed in immature GV-stage oocytes, mature MII-stage oocytes, parthenogenetically activated MII-stage oocytes and in pronuclear embryos (at protein level). During in vitro oocyte maturation, expression initially increases after 12 hours of culture, followed by a strong decline at 30 hours (MI stage) and 44 hours (MII stage). Expression remains constant in MII-stage oocytes after parthenogenetic activation, increasing in two- and four-cell parthenotes. Not detected in blastocyst stage embryos.
messages: In blastocyst expressed in all blastomeres (at protein level). In embryos, expressed in spleen, kidney, liver, fat, muscle, ovary, granulosa cells and cumulus cells.
messages: Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and SPACA9 (By similarity). Interacts with TRIM21. Interacts with NR3C1. Interacts with PPIB. Interacts (via P-domain) with PDIA5. Interacts with CLCC1 (By similarity).
messages: Sarcoplasmic reticulum lumen
messages: The interaction with glycans occurs through a binding site in the globular lectin domain.
messages: The zinc binding sites are localized to the N-domain.
messages: cytosol
messages: extracellular matrix

9823:APEH
gene id: 9823:APEH
uniprot id: P19205
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Expressed in the liver (at protein level).
messages: Homotetramer.
messages: Homotetramerization is required for activity (Probable). Tetramerization results in the formation of a gated channel which is involved in substrate selection and substrate access to the catalytic sites (Probable).
messages: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (By similarity). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins (By similarity).

9823:SLC25A43
gene id: 9823:SLC25A43
uniprot id: A0A4X1W0A8
uniprot id: K7GPX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:NR3C1
gene id: 9823:NR3C1
uniprot id: A0A4X1STV1
uniprot id: A0A4X1SVJ0
uniprot id: A0A8D1ET92
uniprot id: M4QER0
uniprot id: Q9N1U3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity.
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The ligand-binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required.
messages: Cytoplasm
messages: Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23. Directly interacts with UNC45A. Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1 and TGFB1I1. Interacts with NCOA1. Interacts with NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1. Interacts with CLOCK, CRY1 and CRY2 in a ligand-dependent fashion. Interacts with CIART. Interacts with RWDD3. Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3. Interacts with GRIP1. Interacts with NR4A3 (via nuclear receptor DNA-binding domain), represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE). Directly interacts with PNRC2 to attract and form a complex with UPF1 and DCP1A; the interaction leads to rapid mRNA degradation. Interacts with GSK3B. Interacts with FNIP1 and FNIP2. Interacts (via C-terminus) with HNRNPU (via C-terminus). Interacts with MCM3AP (By similarity). Interacts (via domain NR LBD) with HSP90AA1 and HSP90AB1 (By similarity). In the absence of hormonal ligand, interacts with TACC1 (By similarity). Interacts (via NR LBD domain) with ZNF764 (via KRAB domain); the interaction regula…
messages: Increased proteasome-mediated degradation in response to glucocorticoids.
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-208, Ser-231 and Ser-410-phosphorylated forms are mainly cytoplasmic, and the Ser-216-phosphorylated form is nuclear. Phosphorylation at Ser-216 increases transcriptional activity. Phosphorylation at Ser-208, Ser-231 and Ser-410 decreases signaling capacity. Phosphorylation at Ser-410 may protect from glucocorticoid-induced apoptosis. Phosphorylation at Ser-208 and Ser-216 is not required in regulation of chromosome segregation. May be dephosphorylated by PPP5C, attenuates NR3C1 action.
messages: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.
messages: Sumoylation at Lys-282 and Lys-298 negatively regulates its transcriptional activity. Sumoylation at Lys-708 positively regulates its transcriptional activity in the presence of RWDD3. Sumoylation at Lys-282 and Lys-298 is dispensable whereas sumoylation at Lys-708 is critical for the stimulatory effect of RWDD3 on its transcriptional activity. Heat shock increases sumoylation in a RWDD3-dependent manner.
messages: Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.
messages: centrosome
messages: spindle

9823:VSTM5
gene id: 9823:VSTM5
uniprot id: A0A4X1TYN1
uniprot id: F1STK6
names: Subcellular Location Annotation
messages: Membrane

9823:MAP3K14
gene id: 9823:MAP3K14
uniprot id: A0A8D1TWS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

9823:CYBA
gene id: 9823:CYBA
uniprot id: P52650
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain). Interacts with SH3PXD2A (By similarity). Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX3 and NOX4. Interacts with calprotectin (S100A8/9) (By similarity). Interacts with GBP7 (By similarity).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting p47phox binding.
messages: The heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both, and it is possible that more than one heme is present per cytochrome b-245.
messages: Ubiquitinated at Lys-149 likely by RNF145.

9823:SCG2
gene id: 9823:SCG2
uniprot id: Q5FZP5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Binds calcium with a low-affinity.
messages: Interacts with Secretogranin III/SCG3.
messages: Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
messages: Secreted

9823:ACTRT2
gene id: 9823:ACTRT2
uniprot id: A0A4X1W8S9
uniprot id: A0A8D0S6Y1
names: Similarity
messages: Belongs to the actin family.

9823:VPS51
gene id: 9823:VPS51
uniprot id: A0A4X1UYP1
uniprot id: A0A8D1HXJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.
messages: Endosome
messages: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.
messages: Recycling endosome
messages: trans-Golgi network

9823:TMEM18
gene id: 9823:TMEM18
uniprot id: A0A4X1UM98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM18 family.
messages: Membrane
messages: Nucleus membrane

9823:PI4K2A
gene id: 9823:PI4K2A
uniprot id: A0A4X1U7Y0
uniprot id: F1S8X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9823:SNED1
gene id: 9823:SNED1
uniprot id: A0A8D0V1R5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CTSZ
gene id: 9823:CTSZ
uniprot id: A0A4X1UVH7
uniprot id: A5GFX7
names: Similarity
messages: Belongs to the peptidase C1 family.

9823:GPR1
gene id: 9823:GPR1
uniprot id: A0A4X1UXN1
uniprot id: F1SHD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9823:PRKN
gene id: 9823:PRKN
uniprot id: Q1WDP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. Parkin subfamily.
messages: Forms an E3 ubiquitin ligase complex.
messages: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
messages: Mitochondrion
messages: cytosol

9823:RTCB
gene id: 9823:RTCB
uniprot id: Q19PY3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.
messages: Nucleus

9823:LOC100516627
gene id: 9823:LOC100516627
uniprot id: A0A4X1UZH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TAGLN2
gene id: 9823:TAGLN2
uniprot id: A0A4X1VV05
uniprot id: A0A8D1VYG7
names: Similarity
messages: Belongs to the calponin family.

9823:EMSY
gene id: 9823:EMSY
uniprot id: A0A287AIH4
uniprot id: A0A480EY27
uniprot id: A0A480WC73
uniprot id: A0A4X1UKE9
uniprot id: A0A8D0IDZ4
uniprot id: A0A8D1ZS73
names: Subcellular Location Annotation
messages: Nucleus

9823:GAL3ST2
gene id: 9823:GAL3ST2
uniprot id: Q6XQG9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-3-O-sulfotransferase family.
messages: Golgi stack membrane
messages: Strongly inhibited by Cu(2+) and Zn(2+).
messages: Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency (By similarity).

9823:GLYCTK
gene id: 9823:GLYCTK
uniprot id: A0A4X1VIM6
uniprot id: F1SIX9
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9823:KCND1
gene id: 9823:KCND1
uniprot id: A0A5G2QNS8
uniprot id: A0A8D0V0J3
uniprot id: A0A8D1CDQ9
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

9823:COX7A2
gene id: 9823:COX7A2
uniprot id: A1XQV6
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9823:CHCHD4
gene id: 9823:CHCHD4
uniprot id: A0A4X1U653
uniprot id: F1SPI0
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

9823:LOC100736633
gene id: 9823:LOC100736633
uniprot id: A0A8D1DCJ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:KCNAB2
gene id: 9823:KCNAB2
uniprot id: A0A8D1PPJ2
uniprot id: I3LP21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Membrane
messages: axon
messages: cytoskeleton
messages: synaptosome

9823:ANKS6
gene id: 9823:ANKS6
uniprot id: A0A480EIG2
uniprot id: A0A4X1TV03
uniprot id: A0A4X1TVE0
uniprot id: A0A8D1VZL1
uniprot id: F1SSF0
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9823:GAR1
gene id: 9823:GAR1
uniprot id: A0A4X1UY81
uniprot id: I3LVQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9823:FOXA2
gene id: 9823:FOXA2
uniprot id: A0A286ZU79
uniprot id: A0A8D0SSF8
uniprot id: F1SAU0
names: Subcellular Location Annotation
messages: Nucleus

9823:BCAT2
gene id: 9823:BCAT2
uniprot id: A0A287BER5
uniprot id: A0A4X1W1Q7
uniprot id: A0A5G2RDA5
uniprot id: A0A8D1TR22
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9823:SIX1
gene id: 9823:SIX1
uniprot id: A0A4X1WCT7
uniprot id: E5DCJ4
names: Subcellular Location Annotation
messages: Nucleus

9823:ALG14
gene id: 9823:ALG14
uniprot id: A0A8D1PEF8
uniprot id: F1S544
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

9823:TRPT1
gene id: 9823:TRPT1
uniprot id: A0A8D0VL97
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

9823:PBX2
gene id: 9823:PBX2
uniprot id: A0A4X1V7G0
uniprot id: A5A8X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9823:DMC1
gene id: 9823:DMC1
uniprot id: A0A8D0V998
uniprot id: F1SKQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

9823:POLR2L
gene id: 9823:POLR2L
uniprot id: A0A4X1VYD0
uniprot id: A0A8W4F9W9
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

9823:LOC100737613
gene id: 9823:LOC100737613
uniprot id: A0A4X1TWI5
uniprot id: A0A8D0KLC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SH2B3
gene id: 9823:SH2B3
uniprot id: A0A8D1D8T9
uniprot id: F1RMZ2
names: Similarity
messages: Belongs to the SH2B adapter family.

9823:WNT7A
gene id: 9823:WNT7A
uniprot id: A0A287AGQ6
uniprot id: A0A8D2C3X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:SLC51A
gene id: 9823:SLC51A
uniprot id: A0A4X1TWX2
uniprot id: F1SQV7
names: Subcellular Location Annotation
messages: Membrane

9823:MNS1
gene id: 9823:MNS1
uniprot id: A0A4X1TJ85
uniprot id: A0A5G2RCJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNS1 family.
messages: Nucleus
messages: cilium axoneme
messages: flagellum axoneme

9823:LOC100623541
gene id: 9823:LOC100623541
uniprot id: A0A4X1VZ45
uniprot id: A0A8D0JVD8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:ING2
gene id: 9823:ING2
uniprot id: A0A4X1VYP4
uniprot id: I3LVN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9823:DCP1A
gene id: 9823:DCP1A
uniprot id: A0A8D1AZG7
names: Similarity
messages: Belongs to the DCP1 family.

9823:MAP3K12
gene id: 9823:MAP3K12
uniprot id: A0A8D0NW83
uniprot id: A0A8D1LCE5
uniprot id: A0A8D1Y1T9
uniprot id: F1SFP4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: May be an activator of the JNK/SAPK pathway.

9823:BCL7C
gene id: 9823:BCL7C
uniprot id: A0A4X1TMW7
uniprot id: A0A4X1TN19
uniprot id: F1RG97
names: Similarity
messages: Belongs to the BCL7 family.

9823:PRICKLE3
gene id: 9823:PRICKLE3
uniprot id: A0A4X1SYC1
uniprot id: F1RW44
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9823:BLK
gene id: 9823:BLK
uniprot id: A0A481ASF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:GABRE
gene id: 9823:GABRE
uniprot id: A0A8D1J1C9
uniprot id: F1S2D3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:HOPX
gene id: 9823:HOPX
uniprot id: Q8MJD6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
messages: Cytoplasm
messages: Interacts with serum response factor (SRF). Component of a large complex containing histone deacetylases such as HDAC2. Interacts with the acetylated forms of HSPA1A and HSPA1B. Interacts with HSPA8.
messages: Nucleus

9823:CD200R1L
gene id: 9823:CD200R1L
uniprot id: A0A8D0LH50
uniprot id: A0A8D1FDD3
names: Similarity
messages: Belongs to the CD200R family.

9823:RPS23
gene id: 9823:RPS23
uniprot id: Q6SA96
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with the African swine fever virus (ASFV) ubiquitin-conjugating enzyme UBCv1; this interaction probably plays a role in the viral regulation of host protein synthesis.
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit (PubMed:24930395). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:24930395). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
messages: Cytoplasm
messages: Hydroxylation at Pro-62 affects translation termination efficiency.
messages: Rough endoplasmic reticulum
messages: cytosol
messages: nucleolus

9823:WEE1
gene id: 9823:WEE1
uniprot id: A0A4X1TU94
uniprot id: F1S6U8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

9823:EBP
gene id: 9823:EBP
uniprot id: A0A8D0UAL8
uniprot id: D0G6S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:FLVCR2
gene id: 9823:FLVCR2
uniprot id: B7TJ17
names: Subcellular Location Annotation
messages: Membrane

9823:ADAM19
gene id: 9823:ADAM19
uniprot id: A0A8D1I4L9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100515649
gene id: 9823:LOC100515649
uniprot id: A0A5G2R5D4
uniprot id: A0A8D0YC59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:EXOC7
gene id: 9823:EXOC7
uniprot id: A0A480WY60
uniprot id: A0A481AI88
uniprot id: A0A8D0SEB6
uniprot id: A0A8D1Q2G3
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9823:EXOSC1
gene id: 9823:EXOSC1
uniprot id: A0A4X1UA33
uniprot id: A0A8D0TE59
names: Subcellular Location Annotation
messages: Cytoplasm

9823:SLC25A33
gene id: 9823:SLC25A33
uniprot id: A0A287BLT7
uniprot id: A0A4X1W7Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:VNN2
gene id: 9823:VNN2
uniprot id: A0A4X1V8P2
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9823:COQ2
gene id: 9823:COQ2
uniprot id: A0A287B031
uniprot id: A0A4X1TL08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

9823:EFTUD2
gene id: 9823:EFTUD2
uniprot id: A0A8D1HBP4
uniprot id: F1RQZ9
names: Subcellular Location Annotation
messages: Nucleus

9823:SMUG1
gene id: 9823:SMUG1
uniprot id: A0A4X1W4T3
uniprot id: A0A8D1GGN1
uniprot id: A0A8D2BBJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9823:RARS
gene id: 9823:RARS
uniprot id: A0A8D1RIW8
uniprot id: F1RR89
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9823:MOGAT2
gene id: 9823:MOGAT2
uniprot id: A0A5G2QHM2
uniprot id: A0A8D0W744
uniprot id: D0G779
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DHH
gene id: 9823:DHH
uniprot id: A0A4X1WCP1
uniprot id: F1SJ10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9823:CCND2
gene id: 9823:CCND2
uniprot id: Q8WNW2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
messages: Nucleus
messages: Nucleus membrane
messages: Phosphorylation at Thr-279 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex.
messages: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
messages: Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-279 phosphorylation. The DCX(AMBRA1) complex represents the major regulator of CCND2 stability during the G1/S transition (By similarity). Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation (By similarity).

9823:LTBP2
gene id: 9823:LTBP2
uniprot id: A0A5G2QZZ4
uniprot id: F1S2T5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:TRAPPC1
gene id: 9823:TRAPPC1
uniprot id: A0A4X1V846
uniprot id: A0A8D0K2H2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9823:NAB2
gene id: 9823:NAB2
uniprot id: A0A8D0PXE4
uniprot id: I6L5G0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9823:PSMD2
gene id: 9823:PSMD2
uniprot id: A0A480JRT9
uniprot id: A0A8D0IXB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9823:FAM216A
gene id: 9823:FAM216A
uniprot id: A0A8D1R6I3
uniprot id: F1RNN1
names: Similarity
messages: Belongs to the FAM216 family.

9823:NEDD8
gene id: 9823:NEDD8
uniprot id: A0A8D0U3H9
uniprot id: A0A8D1I6C1
names: Similarity
messages: Belongs to the ubiquitin family.

9823:B3GNT7
gene id: 9823:B3GNT7
uniprot id: A0A287BKI9
uniprot id: A0A4X1TI73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:STX11
gene id: 9823:STX11
uniprot id: A0A8D0YJI5
uniprot id: F1S731
names: Similarity
messages: Belongs to the syntaxin family.

9823:ADIG
gene id: 9823:ADIG
uniprot id: Q30C86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adipogenin family.
messages: Membrane
messages: Nucleus
messages: Plays a role in stimulating adipocyte differentiation and development.

9823:ORMDL3
gene id: 9823:ORMDL3
uniprot id: A0A4X1UGJ1
uniprot id: A0A8D0HW16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9823:RAB14
gene id: 9823:RAB14
uniprot id: A0A4X1UKV3
uniprot id: A0A8D1BT00
uniprot id: Q52NJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with KIF16B. Interacts with ZFYVE20 (By similarity).
messages: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity).
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9823:LYVE1
gene id: 9823:LYVE1
uniprot id: A0A8D1ZLE8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:MELK
gene id: 9823:MELK
uniprot id: A0A480JCS7
uniprot id: A0A8D2BLP3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9823:GAMT
gene id: 9823:GAMT
uniprot id: A0A286ZU36
uniprot id: A0A4X1VP82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.
messages: Monomer.

9823:ITM2A
gene id: 9823:ITM2A
uniprot id: A0A4X1W489
uniprot id: K7GMP3
uniprot id: Q52NJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9823:SLA
gene id: 9823:SLA
uniprot id: A0A4X1SRU5
uniprot id: K7GT15
names: Subcellular Location Annotation
messages: Cytoplasm

9823:RNASEH2B
gene id: 9823:RNASEH2B
uniprot id: A0A480JH42
uniprot id: A0A8D0YYE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

9823:MRPL14
gene id: 9823:MRPL14
uniprot id: A0A287BSR7
uniprot id: A0A4X1V5Z4
uniprot id: A0A8D0MZ28
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9823:SPCS2
gene id: 9823:SPCS2
uniprot id: A0A8D1S1R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:SRPRA
gene id: 9823:SRPRA
uniprot id: A0A8D0U477
uniprot id: K9IVR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:TRPC6
gene id: 9823:TRPC6
uniprot id: A0A8D1IRE0
names: Subcellular Location Annotation
messages: Membrane

9823:MTX1
gene id: 9823:MTX1
uniprot id: Q27HK4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metaxin family.
messages: Interacts with MTX2/metaxin-2 (By similarity). Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13 (By similarity). This complex was also known under the names MINOS or MitOS complex (By similarity). The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (By similarity). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex (By similarity). Interacts with ARMC1 (By similarity).
messages: Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).
messages: Mitochondrion outer membrane
messages: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

9823:IDH1
gene id: 9823:IDH1
uniprot id: A0A4X1UYV3
uniprot id: A0A4X1UZU9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Homodimer.

9823:CALCRL
gene id: 9823:CALCRL
uniprot id: A0A4X1TUL8
uniprot id: A0A8D0TIQ4
uniprot id: Q8WN93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Detected in lung and coronary artery.
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2 (By similarity).
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9823:FICD
gene id: 9823:FICD
uniprot id: A0A480X7L8
names: Similarity
messages: Belongs to the fic family.

9823:LOC100623890
gene id: 9823:LOC100623890
uniprot id: A0A8D0RL81
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FUS
gene id: 9823:FUS
uniprot id: A0A4X1TF04
uniprot id: G8ENL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9823:TMOD4
gene id: 9823:TMOD4
uniprot id: A0A286ZL64
uniprot id: A0A8D0XMX7
names: Subcellular Location Annotation
messages: cytoskeleton

9823:VPS4B
gene id: 9823:VPS4B
uniprot id: A0A287BA12
uniprot id: A0A8D0XD99
names: Similarity
messages: Belongs to the AAA ATPase family.

9823:MDH1
gene id: 9823:MDH1
uniprot id: A0A480JV95
uniprot id: P11708
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation.
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).
messages: Homodimer.
messages: ISGylated.
messages: cytosol

9823:CTNS
gene id: 9823:CTNS
uniprot id: A0A4X1UAJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

9823:SFXN2
gene id: 9823:SFXN2
uniprot id: A0A4X1TTL7
uniprot id: F1S852
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9823:STAT4
gene id: 9823:STAT4
uniprot id: A0A8D0WTT9
uniprot id: E1U8C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9823:DBP
gene id: 9823:DBP
uniprot id: A0A4X1VUT2
uniprot id: F1RIP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9823:LOC100153325
gene id: 9823:LOC100153325
uniprot id: A0A4X1WC40
uniprot id: Q304W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:SAP30L
gene id: 9823:SAP30L
uniprot id: A0A287ABA7
uniprot id: A0A4X1TTB1
names: Similarity
messages: Belongs to the SAP30 family.

9823:P4HA2
gene id: 9823:P4HA2
uniprot id: A0A4X1UQU2
uniprot id: A0A4X1UR01
uniprot id: I3L5Y0
uniprot id: I3L769
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9823:POLR3G
gene id: 9823:POLR3G
uniprot id: A0A4X1TD65
uniprot id: A0A8D0RL15
uniprot id: A0A8D1CAB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9823:IL1RAP
gene id: 9823:IL1RAP
uniprot id: A0A4X1UBM6
uniprot id: A0A4X1UCR9
uniprot id: A0A8D0TMK2
uniprot id: A0A8D1N881
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9823:ACSM2B
gene id: 9823:ACSM2B
uniprot id: A0A8D0YVA5
uniprot id: F1RPB0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:MBOAT4
gene id: 9823:MBOAT4
uniprot id: D7RJV9
names: Subcellular Location Annotation
messages: Membrane

9823:PR39
gene id: 9823:PR39
uniprot id: P80054
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cathelicidin family.
messages: Exerts a potent antimicrobial activity against both E.coli and B.megaterium.
messages: Secreted
messages: Small intestine and bone marrow.

9823:MAP3K6
gene id: 9823:MAP3K6
uniprot id: A0A8D0U1R6
uniprot id: K7GLX4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9823:LOC100152848
gene id: 9823:LOC100152848
uniprot id: A0A4X1VXG0
uniprot id: F1RNC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC102167936
gene id: 9823:LOC102167936
uniprot id: A0A5G2QWP5
uniprot id: A0A8D0R4U2
names: Similarity
messages: Belongs to the bZIP family. NFIL3 subfamily.

9823:ESCO1
gene id: 9823:ESCO1
uniprot id: A0A287B1A4
uniprot id: A0A4X1VNL4
names: Subcellular Location Annotation
messages: Nucleus

9823:TOMM40
gene id: 9823:TOMM40
uniprot id: A0A8D1K2F8
uniprot id: D0V557
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:PCSK4
gene id: 9823:PCSK4
uniprot id: I3LT46
names: Similarity
messages: Belongs to the peptidase S8 family.

9823:SAR1A
gene id: 9823:SAR1A
uniprot id: Q52NJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Interacts with B3GAT1.
messages: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity).

9823:SV2A
gene id: 9823:SV2A
uniprot id: A0A8D0X9K1
uniprot id: F1SDF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9823:SEMA4F
gene id: 9823:SEMA4F
uniprot id: A0A287AF71
uniprot id: A0A287BS05
uniprot id: A0A4X1W6S8
uniprot id: A0A4X1W863
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DES
gene id: 9823:DES
uniprot id: P02540
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylation prevents ability to form intermediate filaments.
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Homomer. Interacts with DST. Interacts with MTM1. Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament. Interacts with CRYAB. Interacts with NEB (via nebulin repeats 160-164). Interacts (via rod region) with NEBL (via nebulin repeats 1-5). Interacts with ASB2; the interaction targets DES for proteasomal degradation (By similarity). Interacts with PKP1 (By similarity).
messages: Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin.
messages: Nucleus
messages: Phosphorylation at Ser-7, Ser-28 and Ser-32 by CDK1 and phosphorylation at Ser-60 by AURKB contribute to efficient separation of desmin intermediate filaments during mitosis.
messages: Ubiquitination by a SCF-like complex containing ASB2 leads to proteasomal degradation.
messages: Z line
messages: sarcolemma

9823:STX12
gene id: 9823:STX12
uniprot id: A0A8D0XI23
names: Similarity
messages: Belongs to the syntaxin family.

9823:KDM1B
gene id: 9823:KDM1B
uniprot id: A0A480TKW4
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9823:CLDN10
gene id: 9823:CLDN10
uniprot id: A0A8D0P4B8
uniprot id: F1RP52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:TATDN1
gene id: 9823:TATDN1
uniprot id: A0A287A0F5
uniprot id: A0A4X1T073
uniprot id: A0A8D0ZR77
uniprot id: I3LKU9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9823:APC2
gene id: 9823:APC2
uniprot id: F2X0U7
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9823:DPYSL4
gene id: 9823:DPYSL4
uniprot id: A0A480URP4
uniprot id: A0A8D1V0Q8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9823:WNT10B
gene id: 9823:WNT10B
uniprot id: U5XKA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:AIF1L
gene id: 9823:AIF1L
uniprot id: A0A4X1TC08
names: Subcellular Location Annotation
messages: ruffle membrane

9823:RBM4B
gene id: 9823:RBM4B
uniprot id: Q06AT9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with TNPO3, which may mediate nuclear import of the protein.
messages: Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity).
messages: nucleolus

9823:MRPS18C
gene id: 9823:MRPS18C
uniprot id: A0A8D0T668
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9823:PHACTR3
gene id: 9823:PHACTR3
uniprot id: A0A8D0MD19
uniprot id: A0A8D1Y6M4
uniprot id: A5GFN9
uniprot id: A5GFP0
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9823:OPN1SW
gene id: 9823:OPN1SW
uniprot id: Q8MIR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9823:KEF22 p07
gene id: 9823:KEF22_p07
uniprot id: Q35916
uniprot id: Q69G29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9823:EPB41
gene id: 9823:EPB41
uniprot id: A0A287ANL7
uniprot id: A0A287BDW2
uniprot id: A0A8D0Q5C9
uniprot id: A0A8D0UDT1
uniprot id: A0A8D0X7Q9
uniprot id: A0A8D1CAX1
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex
messages: cytoskeleton

9823:GTF2I
gene id: 9823:GTF2I
uniprot id: A0A480HY11
uniprot id: A0A480I447
uniprot id: A0A480SDW2
uniprot id: A0A480WNN3
uniprot id: A0A5K1VLI8
uniprot id: A0A8D0HXG2
uniprot id: A0A8D0LET8
uniprot id: A0A8D1AB35
uniprot id: A0A8D1E3Z3
uniprot id: A0A8D1VZY8
uniprot id: A0A8D1XB59
uniprot id: F1RJL2
names: Subcellular Location Annotation
messages: Nucleus

9823:TMEM54
gene id: 9823:TMEM54
uniprot id: A0A286ZLI1
uniprot id: A0A8D0K925
uniprot id: A0A8D2BMV6
uniprot id: I3LA99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9823:COX17
gene id: 9823:COX17
uniprot id: A0A8D1IAS9
uniprot id: D2XUP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9823:USP44
gene id: 9823:USP44
uniprot id: A0A287AMI4
uniprot id: A0A8D1GDB9
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:BMPR1A
gene id: 9823:BMPR1A
uniprot id: A0A8D0XWJ4
uniprot id: E9M2M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9823:EREG
gene id: 9823:EREG
uniprot id: A0A287A6I2
uniprot id: A0A4X1T4H4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:EN2
gene id: 9823:EN2
uniprot id: A0A287AUN5
uniprot id: A0A8D1UFJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

9823:HMGCR
gene id: 9823:HMGCR
uniprot id: C7S800
uniprot id: Q1W675
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HMG-CoA reductase family.
messages: Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.
messages: Endoplasmic reticulum membrane
messages: High expression found in liver, heart, kidney, bladder and subcutaneous fat. Lower levels in lung, uterus and large intestine. Lowest levels in cerebrum, spleen, spinal cord, stomach, ovary, longissimus muscle, and small intestine.
messages: Homotetramer. Homodimer. Interacts (via its SSD) with INSIG1; the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1.
messages: Membrane
messages: N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.
messages: Peroxisome membrane
messages: Phosphorylated. Phosphorylation at Ser-869 reduces the catalytic activity.
messages: Regulated by a negative feedback mechanism through sterols and non-sterol metabolites derived from mevalonate (By similarity). Phosphorylation at Ser-869 down-regulates the catalytic activity (By similarity).
messages: Undergoes sterol-mediated ubiquitination and ER-associated degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1 or INSIG2. The INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78, RNF139 or RNF145, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. The INSIG2-binding leads to the recruitment of the ubiquitin ligase RNF139, initiating ubiquitination of the reductase. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein.

9823:WNT11
gene id: 9823:WNT11
uniprot id: A0A5G2QZA2
uniprot id: A0A8D1MKJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:LOC100151788
gene id: 9823:LOC100151788
uniprot id: F1S246
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:ROMO1
gene id: 9823:ROMO1
uniprot id: A0A4X1TBQ2
uniprot id: A0A8D1H5Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9823:TSPYL2
gene id: 9823:TSPYL2
uniprot id: A0A4X1T268
uniprot id: A0A8D2CBR6
uniprot id: F1RUI4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9823:RCL1
gene id: 9823:RCL1
uniprot id: A0A4X1W823
uniprot id: A0A5G2R2D8
uniprot id: A0A8D1HPQ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: nucleolus

9823:IFN-ALPHA-10
gene id: 9823:IFN-ALPHA-10
uniprot id: Q304V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:MTMR8
gene id: 9823:MTMR8
uniprot id: A0A480L019
uniprot id: A0A8D0UQ79
uniprot id: A0A8D1ZP82
uniprot id: I3LJL9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9823:MRRF
gene id: 9823:MRRF
uniprot id: A0A8D1JFI4
uniprot id: F1SLQ7
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9823:AQP9
gene id: 9823:AQP9
uniprot id: A0A8D0K043
uniprot id: A8WCF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:LAMP5
gene id: 9823:LAMP5
uniprot id: A0A8D0Y8L7
uniprot id: F1SBK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Membrane

9823:TMEM86A
gene id: 9823:TMEM86A
uniprot id: A0A4X1T895
uniprot id: F1SFX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9823:SETDB1
gene id: 9823:SETDB1
uniprot id: A0A8D1PZT6
uniprot id: F1SS95
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9823:TMEM134
gene id: 9823:TMEM134
uniprot id: A0A8D1GJR2
uniprot id: F1RUZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

9823:PLIN1
gene id: 9823:PLIN1
uniprot id: Q2TCH2
names: Similarity
messages: Belongs to the perilipin family.

9823:EHF
gene id: 9823:EHF
uniprot id: A0A4X1SQF9
uniprot id: A0A8D0Z6P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:RPL10A
gene id: 9823:RPL10A
uniprot id: A0A4X1T0H0
uniprot id: A0A8D1U2F2
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9823:CHST1
gene id: 9823:CHST1
uniprot id: A0A4X1SF01
uniprot id: F1SHJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9823:TAPT1
gene id: 9823:TAPT1
uniprot id: A0A8D1B7C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

9823:TEAD4
gene id: 9823:TEAD4
uniprot id: B7SFP7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

9823:FCF1
gene id: 9823:FCF1
uniprot id: A0A4X1TD48
uniprot id: A0A8D0KGJ8
uniprot id: A0A8D1C5Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9823:GPATCH11
gene id: 9823:GPATCH11
uniprot id: A0A4X1T1R0
uniprot id: A0A8D1HTZ5
names: Similarity
messages: Belongs to the GPATCH11 family.

9823:IFRD1
gene id: 9823:IFRD1
uniprot id: A0A287AJN2
uniprot id: A0A4X1VYZ3
uniprot id: Q5S1U6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IFRD family.
messages: Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity).
messages: Interacts with PSIP1/LEDGF.

9823:SNRPE
gene id: 9823:SNRPE
uniprot id: A1XQR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with SMN1; the interaction is direct. Interacts with GEMIN2 (via N-terminus); the interaction is direct. Interacts with SNRPF; the interaction is direct. Interacts with SNRPG; the interaction is direct.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9823:UNC45A
gene id: 9823:UNC45A
uniprot id: A0A480X1W1
uniprot id: A0A8D0I6T6
names: Subcellular Location Annotation
messages: perinuclear region

9823:TMA16
gene id: 9823:TMA16
uniprot id: A0A4X1TTF1
uniprot id: F1RTW4
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9823:WNT2B
gene id: 9823:WNT2B
uniprot id: A0A8D1UI92
uniprot id: F1SBP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:PEX16
gene id: 9823:PEX16
uniprot id: A0A480PCT8
uniprot id: A0A4X1SEG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

9823:CNN1
gene id: 9823:CNN1
uniprot id: A0A4X1VKD2
uniprot id: Q08092
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the calponin family.
messages: Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.
messages: Smooth muscle, and tissues containing significant amounts of smooth muscle.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9823:MRPL27
gene id: 9823:MRPL27
uniprot id: A0A4X1U0F6
uniprot id: A0A8D1NY38
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9823:COPG2
gene id: 9823:COPG2
uniprot id: F6JTE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9823:SGO1
gene id: 9823:SGO1
uniprot id: A0A4X1UJE9
uniprot id: F1RS59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9823:APOO
gene id: 9823:APOO
uniprot id: A0A8D0R0S7
uniprot id: K7GPW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9823:PDHX
gene id: 9823:PDHX
uniprot id: A0A8D0UCV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9823:SERPINE1
gene id: 9823:SERPINE1
uniprot id: P79335
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms a heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Interacts with PPP1CB. In complex with PLAU/uPA, interacts with PLAUR/uPAR (By similarity). Interacts with SORL1 and LRP1, either alone or in complex with PLAU; these interactions are abolished in the presence of LRPAP1/RAP (By similarity). The ternary complex composed of PLAUR-PLAU-PAI1 also interacts with SORL1 (By similarity). Also interacts with SORL1, when complexed to PLAT/tPA (By similarity).
messages: Secreted
messages: Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).

9823:TULP3
gene id: 9823:TULP3
uniprot id: A0A287BTI9
uniprot id: A0A480JWW4
uniprot id: A0A4X1UKF7
uniprot id: A0A4X1UM45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9823:PSMC3
gene id: 9823:PSMC3
uniprot id: A0A8D0K1V5
uniprot id: A0A8W4FR49
names: Similarity
messages: Belongs to the AAA ATPase family.

9823:EIF4E1B
gene id: 9823:EIF4E1B
uniprot id: A0A480EPA0
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9823:COPS5
gene id: 9823:COPS5
uniprot id: A7TX80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9823:IL21
gene id: 9823:IL21
uniprot id: Q76LU6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity (PubMed:15107555). Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
messages: It is uncertain whether Met-1 or Met-7 is the initiator.
messages: Secreted

9823:POLR2J
gene id: 9823:POLR2J
uniprot id: A0A8D0TE17
uniprot id: F1RKE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

9823:ELK4
gene id: 9823:ELK4
uniprot id: A0A286ZLL4
uniprot id: A0A4X1UUF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:PCOLCE2
gene id: 9823:PCOLCE2
uniprot id: A0A4X1T6H1
uniprot id: F1SKE7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:PTGES2
gene id: 9823:PTGES2
uniprot id: A0A8D1K232
uniprot id: F1RRY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

9823:HCRT
gene id: 9823:HCRT
uniprot id: O77668
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity).
messages: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity).
messages: Cytoplasmic vesicle
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Specific enzymatic cleavages at paired basic residues yield the different active peptides.
messages: Synapse

9823:LOC100518059
gene id: 9823:LOC100518059
uniprot id: A0A4X1UIS2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:KCTD20
gene id: 9823:KCTD20
uniprot id: A0A481D8Q7
uniprot id: A0A4X1STM3
uniprot id: A0A8D0QN82
names: Subcellular Location Annotation
messages: Cytoplasm

9823:PLSCR3
gene id: 9823:PLSCR3
uniprot id: A0A8D1AJD8
uniprot id: I3LHI3
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9823:GRN
gene id: 9823:GRN
uniprot id: Q1EG87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

9823:SPINK4
gene id: 9823:SPINK4
uniprot id: P37109
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Inhibits the glucose-induced insulin secretion from perfused pancreas; also plays a role in the immune system. Does not inhibit trypsin.
messages: Secreted
messages: Synthesized in duodenal goblet cells and in monocytes in bone marrow and blood.

9823:ADRB2
gene id: 9823:ADRB2
uniprot id: Q28997
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity).
messages: Binds NHERF1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC (By similarity). Interacts with USP20 and USP33 (By similarity). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3. Interacts with NEDD4 (By similarity). Interacts with MARCHF2 (By similarity).
messages: Cell membrane
messages: Early endosome
messages: Expressed in heart, liver, lung, skeletal muscle and subcutaneous adipose tissue.
messages: Golgi apparatus
messages: Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.
messages: Palmitoylated. Mainly palmitoylated at Cys-341. Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi. Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor. Could be depalmitoylated by LYPLA1 at the plasma membrane.
messages: Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity).
messages: Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
messages: Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
messages: Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent (By similarity).

9823:IL13RA2
gene id: 9823:IL13RA2
uniprot id: A0A4X1VZZ9
uniprot id: F1RWT5
names: Subcellular Location Annotation
messages: Membrane

9823:GPX4
gene id: 9823:GPX4
uniprot id: P36968
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutathione peroxidase family.
messages: Cytoplasm
messages: Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (PubMed:3978121, PubMed:2386798, PubMed:8135530). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (PubMed:8135530, PubMed:2386798, PubMed:3978121). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (PubMed:8617728).
messages: Mitochondrion
messages: Monomer (PubMed:3978121). Has a tendency to form higher mass oligomers (By similarity).

9823:EEF1A1
gene id: 9823:EEF1A1
uniprot id: A0A8D0I6I6
uniprot id: Q0PY11
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9823:PSMA7
gene id: 9823:PSMA7
uniprot id: A0A287AT18
uniprot id: A0A8D1GFG8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9823:PIK3C3
gene id: 9823:PIK3C3
uniprot id: Q5D891
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family.
messages: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
messages: Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 associating with additional regulatory/auxilliary subunits to form alternative complex forms. Alternative complex forms containing a forth regulatory subunit in a mutually exclusive manner are: the PI3K complex I (PI3KC3-C1) containing ATG14, and the PI3K complex II (PI3KC3-C2) containing UVRAG. PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex. Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits such as RUBCN, SH3GLB1/Bif-1 and AMBRA1. PI3KC3-C1 probably associates with PIK3CB. Interacts with RAB7A in the presence of PIK3R4. Interacts with AMBRA1. Interacts with BECN1P1/BECN2. Interacts with SLAMF1. May be a component of a complex composed of RAB5A (in GDP-bound form), DYN2 and PIK3C3 (By similarity). Interacts with NCKAP1L (By similarity). Interacts with ATG14; this interaction is increased in the absence of TMEM39A (By similarity). Interacts with STEEP1; the interaction is STING1-dependent and required for trafficking of STING1 from the endoplasmic reticulum (By similarity). Interacts with YWHAG (By similarity).
messages: Late endosome
messages: Midbody
messages: Ubiquitinated via 'Lys-29'- and 'Lys-48'-linked ubiquitination by UBE3C, promoting its degradation. Deubiquitination by ZRANB1/TRABID promotes its stabilization, leading to autophagosome maturation.
messages: autophagosome

9823:AKAP3
gene id: 9823:AKAP3
uniprot id: A0A8D1RRN7
uniprot id: D3K5M3
names: Similarity
messages: Belongs to the AKAP110 family.

9823:MRI1
gene id: 9823:MRI1
uniprot id: A0A8D0KCG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

9823:LOC100620249
gene id: 9823:LOC100620249
uniprot id: A0A8D1N3T0
uniprot id: F1S636
names: Similarity
messages: Belongs to the peptidase A1 family.

9823:GBX2
gene id: 9823:GBX2
uniprot id: A0A4X1TAE5
uniprot id: F1SM11
names: Subcellular Location Annotation
messages: Nucleus

9823:CNP
gene id: 9823:CNP
uniprot id: A0A480ZVP3
uniprot id: A0A4X1U7L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

9823:FOXH1
gene id: 9823:FOXH1
uniprot id: A0A8D1EPH6
names: Subcellular Location Annotation
messages: Nucleus

9823:KCNA5
gene id: 9823:KCNA5
uniprot id: A0A4X1UM58
uniprot id: Q5USC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

9823:SIX2
gene id: 9823:SIX2
uniprot id: A0A4X1SIW3
uniprot id: F1S5K5
names: Subcellular Location Annotation
messages: Nucleus

9823:TVP23B
gene id: 9823:TVP23B
uniprot id: A0A287BIS8
uniprot id: A0A5K1VLD8
uniprot id: A0A8D1EAE9
uniprot id: A0A8D1U9C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9823:IER3IP1
gene id: 9823:IER3IP1
uniprot id: A0A4X1ULT2
uniprot id: F1RZY2
names: Similarity
messages: Belongs to the YOS1 family.

9823:APTX
gene id: 9823:APTX
uniprot id: Q7YRZ1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
messages: Interacts with single-strand break repair proteins XRCC1, XRCC4, ADPRT/PARP1 and p53/TP53. Interacts with NCL. Interacts (via FHA-like domain) with MDC1 (phosphorylated).
messages: The C2H2-type zinc finger mediates DNA-binding.
messages: The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4.
messages: The HIT domain is required for enzymatic activity.
messages: The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide.
messages: nucleolus
messages: nucleoplasm

9823:LPAR3
gene id: 9823:LPAR3
uniprot id: A0A8D0JST7
uniprot id: C5G5X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:CD55
gene id: 9823:CD55
uniprot id: Q9GLM0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100627234
gene id: 9823:LOC100627234
uniprot id: A0A287BB81
uniprot id: A0A8D0K8I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LIN7C
gene id: 9823:LIN7C
uniprot id: A0A8D0YQY9
uniprot id: A0A8D1GJU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9823:GALNS
gene id: 9823:GALNS
uniprot id: Q8WNQ7
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Homodimer.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9823:MRPL24
gene id: 9823:MRPL24
uniprot id: A0A8D0QJH8
uniprot id: F1RHJ1
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9823:GRIN3B
gene id: 9823:GRIN3B
uniprot id: A0A8D1IWF5
uniprot id: I3LMD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9823:CDKAL1
gene id: 9823:CDKAL1
uniprot id: F1RUG0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

9823:LOC100626407
gene id: 9823:LOC100626407
uniprot id: A0A480F155
names: Subcellular Location Annotation
messages: Membrane

9823:RPL24
gene id: 9823:RPL24
uniprot id: A0A4X1SH42
uniprot id: A0A8D2CH72
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9823:MRPL43
gene id: 9823:MRPL43
uniprot id: F1S8U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

9823:CCDC85A
gene id: 9823:CCDC85A
uniprot id: A0A286ZUX7
uniprot id: A0A8D0YAA6
uniprot id: A0A8D1KYD7
uniprot id: A0A8D1UA63
uniprot id: A0A8D1Y9F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9823:TMEM59L
gene id: 9823:TMEM59L
uniprot id: A0A4X1U390
uniprot id: F1S907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:AMD1
gene id: 9823:AMD1
uniprot id: A0A480PUC7
uniprot id: A0A4X1VBX0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9823:SNUPN
gene id: 9823:SNUPN
uniprot id: A0A4X1TQ71
uniprot id: A0A8D0N8Q8
uniprot id: A0A8D1I1H9
uniprot id: F1SJ72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

9823:TNFSF9
gene id: 9823:TNFSF9
uniprot id: A0A4X1VSK8
uniprot id: F1SBT1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:IFNG
gene id: 9823:IFNG
uniprot id: A9LN08
uniprot id: P17803
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.
messages: Released primarily from activated T lymphocytes.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9823:CHRNB4
gene id: 9823:CHRNB4
uniprot id: A0A4X1UTL4
uniprot id: A0A8D1LYV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:GAL3ST3
gene id: 9823:GAL3ST3
uniprot id: A0A4X1UB24
uniprot id: I3LDC5
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9823:IFN-ALPHA-14
gene id: 9823:IFN-ALPHA-14
uniprot id: C8CKA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:MFSD9
gene id: 9823:MFSD9
uniprot id: A0A286ZNG6
uniprot id: A0A8D1XCI7
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100736692
gene id: 9823:LOC100736692
uniprot id: A0A8D1ALX2
uniprot id: A0A8W4FGP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CDCA7L
gene id: 9823:CDCA7L
uniprot id: A0A4X1T6W4
uniprot id: A0A8D1IWN3
uniprot id: F1SC06
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:NOSIP
gene id: 9823:NOSIP
uniprot id: A0A4X1VYM4
uniprot id: A0A5G2QVZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

9823:TCEA1
gene id: 9823:TCEA1
uniprot id: A0A4X1T3C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9823:LGR5
gene id: 9823:LGR5
uniprot id: A0A0H4J9E9
uniprot id: A0A4X1VVP4
names: Subcellular Location Annotation
messages: Membrane

9823:TMEM177
gene id: 9823:TMEM177
uniprot id: F1RXW5
names: Function
names: Similarity
messages: Belongs to the TMEM177 family.
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

9823:ADHFE1
gene id: 9823:ADHFE1
uniprot id: A0A8D0YXS2
uniprot id: F1RTZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

9823:USP21
gene id: 9823:USP21
uniprot id: A0A8D1PC95
uniprot id: F1S196
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:SLCO1B3
gene id: 9823:SLCO1B3
uniprot id: A0A4X1VA05
uniprot id: A0A5K1VT10
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:CXHXorf56
gene id: 9823:CXHXorf56
uniprot id: A0A8D0KAE7
uniprot id: F2Z566
names: Similarity
messages: Belongs to the STEEP1 family.

9823:C2
gene id: 9823:C2
uniprot id: A5PF02
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:AHR
gene id: 9823:AHR
uniprot id: A0A0A1ERS1
names: Subcellular Location Annotation
messages: Cytoplasm

9823:LCAT
gene id: 9823:LCAT
uniprot id: C7S7Z9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9823:HMGB2
gene id: 9823:HMGB2
uniprot id: P17741
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMGB family.
messages: Both, HMG box 1 and HMG box 2, show antimicrobial activity.
messages: Chromosome
messages: Cytoplasm
messages: Interacts with POU2F2, POU2F1 and POU3F1. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET. Interacts with LEF1.
messages: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11275566). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE. Has antimicrobial activity in gastrointestinal epithelial tissues. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity. May play a role in germ cell differentiation. Involved in modulation of neurogenesis probably by regulation of neural stem proliferation. Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
messages: Nucleus
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so).
messages: Secreted

9823:GSPT2
gene id: 9823:GSPT2
uniprot id: A0A8D1ZRZ1
uniprot id: F1RUJ9
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9823:MSN
gene id: 9823:MSN
uniprot id: A0A4X1VJQ8
uniprot id: P26042
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.
messages: Apical cell membrane
messages: Binds NHERF1. In resting T-cells, part of a PAG1-NHERF1-MSN complex which is disrupted upon TCR activation. Interacts with PPP1R16B. Interacts with PDZD8. Interacts with SELPLG and SYK; mediates the activation of SYK by SELPLG. Interacts with PDPN (via cytoplasmic domain); activates RHOA and promotes epithelial-mesenchymal transition. Interacts with SPN/CD43 cytoplasmic tail, CD44 and ICAM2 (By similarity).
messages: Cell membrane
messages: Membrane
messages: Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. Phosphorylation on Thr-558 by STK10 negatively regulates lymphocyte migration and polarization (By similarity).
messages: Probably involved in connections of major cytoskeletal structures to the plasma membrane. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation.
messages: S-nitrosylation of Cys-117 is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) implicating the iNOS-S100A8/9 transnitrosylase complex.
messages: The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
messages: cytoskeleton
messages: microvillus
messages: microvillus membrane

9823:COQ9
gene id: 9823:COQ9
uniprot id: A0A480PNJ5
uniprot id: A0A4X1UZ68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

9823:HABP2
gene id: 9823:HABP2
uniprot id: A0A480TIV4
uniprot id: A0A4X1T8P7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:NAP1L4
gene id: 9823:NAP1L4
uniprot id: I6NCL0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9823:ATP6V0D1
gene id: 9823:ATP6V0D1
uniprot id: A0A4X1UJS8
uniprot id: A0A8D0QB91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9823:PLG
gene id: 9823:PLG
uniprot id: P06867
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Cannot be activated with streptokinase.
messages: In the presence of the inhibitor, the activation involves only cleavage after Arg-579, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide (By similarity).
messages: Interacts with CSPG4 and AMOT. Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation. Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4. Angiostatin: Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin.
messages: Kringle domains mediate interaction with CSPG4.
messages: N-linked glycan contains N-acetyllactosamine, sialic acid and is core fucosylated. O-linked glycans consist of Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues (microheterogeneity).
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity).
messages: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.
messages: Secreted

9823:PEA15
gene id: 9823:PEA15
uniprot id: A0A287AGA5
uniprot id: A0A4X1VP31
names: Subcellular Location Annotation
messages: Cytoplasm

9823:EN1
gene id: 9823:EN1
uniprot id: A0A4X1SM98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

9823:MOCS3
gene id: 9823:MOCS3
uniprot id: A5GFZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 acting as a sulfur donor for thiocarboxylation reactions.

9823:HMMR
gene id: 9823:HMMR
uniprot id: A0A5G2RBP4
uniprot id: A0A8D0ZZB4
names: Subcellular Location Annotation
messages: spindle

9823:FAM207A
gene id: 9823:FAM207A
uniprot id: A0A8D1VXL8
uniprot id: I3LJV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

9823:LOC100518442
gene id: 9823:LOC100518442
uniprot id: A0A8D0SF36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:DDB1
gene id: 9823:DDB1
uniprot id: A0A4X1VLC3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

9823:CDK2AP1
gene id: 9823:CDK2AP1
uniprot id: A0A8D1SGB6
uniprot id: F1RFL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9823:ARSK
gene id: 9823:ARSK
uniprot id: A0A480QD42
uniprot id: A0A8D1XHU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome

9823:TMBIM4
gene id: 9823:TMBIM4
uniprot id: A0A480YW12
uniprot id: A0A4X1W3Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9823:PLPPR4
gene id: 9823:PLPPR4
uniprot id: A0A8D0YWJ0
uniprot id: F1S553
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9823:CYP4F2
gene id: 9823:CYP4F2
uniprot id: A0A480QDV1
uniprot id: A0A4X1VIQ8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:STEAP3
gene id: 9823:STEAP3
uniprot id: A0A4X1SMD0
uniprot id: A0A4X1SNA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9823:APOC2
gene id: 9823:APOC2
uniprot id: A0A4X1W295
uniprot id: D3Y264
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
messages: Secreted

9823:CDS1
gene id: 9823:CDS1
uniprot id: Q30GF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9823:DLK1
gene id: 9823:DLK1
uniprot id: B2LYU1
uniprot id: Q0H2C7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:MED21
gene id: 9823:MED21
uniprot id: A0A8D1DDD8
uniprot id: F1SG80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9823:GMNN
gene id: 9823:GMNN
uniprot id: A0A286ZKU4
uniprot id: A0A8D1A8R7
uniprot id: A0A8D1H8Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9823:FAM3D
gene id: 9823:FAM3D
uniprot id: A0A481CXF8
uniprot id: A0A8D0TSR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9823:SPTAN1
gene id: 9823:SPTAN1
uniprot id: A0A8D2CFZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9823:SUSD1
gene id: 9823:SUSD1
uniprot id: F1SNB0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:HSD3B1
gene id: 9823:HSD3B1
uniprot id: D0G6Y4
uniprot id: Q9N119
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
messages: Belongs to the 3-beta-HSD family.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane

9823:PLK4
gene id: 9823:PLK4
uniprot id: A0A480V3H2
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: centriole

9823:DIS3L2
gene id: 9823:DIS3L2
uniprot id: D3K5M4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cytoplasm
messages: P-body
messages: Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.

9823:CCDC167
gene id: 9823:CCDC167
uniprot id: A0A287AUD4
uniprot id: A0A4X1SRW8
names: Subcellular Location Annotation
messages: Membrane

9823:USP45
gene id: 9823:USP45
uniprot id: A0A8D1Y7P9
uniprot id: F1RXY2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:NPC2
gene id: 9823:NPC2
uniprot id: O97763
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NPC2 family.
messages: Binds cholesterol in a hydrophobic pocket; there are no hydrogen bonds between the sterol and the protein.
messages: Endoplasmic reticulum
messages: Found in the fluid from the distal caput to cauda epididymis, not detected in the rete testis and the proximal and middle caput epididymal fluids (at protein level).
messages: Interacts with NPC1 (via the second lumenal domain) in a cholestrol-dependent manner. Interacts with NUS1/NgBR, the interaction stabilizes NCP2 and regulates cholesterol trafficking. Interacts with DHDDS. Interacts with NEDD4L (via C2 domain). Interacts with NPC1L1.
messages: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes (By similarity). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:10366780). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
messages: Lysosome
messages: N-glycosylated. Found in the epididymal fluid as a 19 kDa glycoprotein that is processed during its passage through the epididymis into a 16 kDa protein.
messages: Secreted

9823:CCNB1
gene id: 9823:CCNB1
uniprot id: A0A8D0S4R5
uniprot id: D2IE28
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.

9823:HMOX2
gene id: 9823:HMOX2
uniprot id: A0A4X1VRH0
uniprot id: A0A4X1VSV5
uniprot id: A0A8D0PJC0
uniprot id: F1RK58
names: Similarity
messages: Belongs to the heme oxygenase family.

9823:LOC100522220
gene id: 9823:LOC100522220
uniprot id: A0A8D0UDF0
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9823:HEPH
gene id: 9823:HEPH
uniprot id: A0A4X1VTE4
uniprot id: A0A8D1X3N1
uniprot id: K7GSZ6
names: Similarity
messages: Belongs to the multicopper oxidase family.

9823:ZNF397
gene id: 9823:ZNF397
uniprot id: A0A287B716
uniprot id: A0A4X1VCD0
names: Subcellular Location Annotation
messages: Nucleus

9823:BOD1
gene id: 9823:BOD1
uniprot id: A0A4X1UDJ6
uniprot id: F1SJZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

9823:LHB
gene id: 9823:LHB
uniprot id: P01232
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
messages: Secreted

9823:PDE6C
gene id: 9823:PDE6C
uniprot id: A0A4X1UQX4
uniprot id: F1SC79
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9823:LOC100517149
gene id: 9823:LOC100517149
uniprot id: A0A480EGR6
uniprot id: A0A8D1CVK8
uniprot id: A0A8D1X7Y9
names: Subcellular Location Annotation
messages: Nucleus

9823:PRRT1
gene id: 9823:PRRT1
uniprot id: A5A8Z9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:LOC100151901
gene id: 9823:LOC100151901
uniprot id: A0A4X1V1L8
uniprot id: A0A8D0TSG9
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

9823:MAP2K6
gene id: 9823:MAP2K6
uniprot id: A0A4X1SME1
uniprot id: A0A5K1UKA4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:FZD2
gene id: 9823:FZD2
uniprot id: D3K5N8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:MARCKSL1
gene id: 9823:MARCKSL1
uniprot id: A0A4X1W0E6
names: Similarity
messages: Belongs to the MARCKS family.

9823:POLR2F
gene id: 9823:POLR2F
uniprot id: A0A4X1VEK9
uniprot id: A0A8D1KNW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9823:LOC100518620
gene id: 9823:LOC100518620
uniprot id: A0A287A0X1
uniprot id: A0A4X1UUS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9823:LLPH
gene id: 9823:LLPH
uniprot id: A0A287B8Z8
uniprot id: A0A8D0U5J7
names: Similarity
messages: Belongs to the learning-associated protein family.

9823:TMEM53
gene id: 9823:TMEM53
uniprot id: A0A4X1W3W7
uniprot id: A0A4X1W9T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9823:CLRN2
gene id: 9823:CLRN2
uniprot id: A0A4X1V8B3
uniprot id: I3LUJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9823:SS18L2
gene id: 9823:SS18L2
uniprot id: A0A8D1ZHZ2
uniprot id: F1SRF4
names: Similarity
messages: Belongs to the SS18 family.

9823:DLST
gene id: 9823:DLST
uniprot id: Q9N0F1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (PubMed:10806400). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (PubMed:10806400). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A.

9823:TSPAN6
gene id: 9823:TSPAN6
uniprot id: A0A4X1U084
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:GNPDA1
gene id: 9823:GNPDA1
uniprot id: A0A287AHC2
uniprot id: A0A480UKY8
uniprot id: A0A4X1SSI5
uniprot id: A0A8D1GXI9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9823:PGPEP1L
gene id: 9823:PGPEP1L
uniprot id: A0A8D0QJ06
uniprot id: F1SRY2
names: Similarity
messages: Belongs to the peptidase C15 family.

9823:HSP70.2
gene id: 9823:HSP70.2
uniprot id: A5A8V6
uniprot id: Q6S4N2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress.
messages: May be an auxiliary component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with METTL21A. Interacts with TRIM5 (via B30.2/SPRY domain). Interacts with PRKN. Interacts with FOXP3. Interacts with NOD2; the interaction enhances NOD2 stability. Interacts with DNAJC9 (via J domain). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes. Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non-acetylated form interact with HOPX and STUB1 respectively. Interacts with NEDD1 and SMAD3. Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105. Interacts with DNAJC8.
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein re…
messages: Testis-specific.
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
messages: centrosome

9823:DOK5
gene id: 9823:DOK5
uniprot id: A0A4X1UMC8
uniprot id: A5GFP8
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9823:FFAR3
gene id: 9823:FFAR3
uniprot id: A0A8D1ZAQ9
uniprot id: I1X3K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:LOC100523537
gene id: 9823:LOC100523537
uniprot id: A0A8D1PY12
uniprot id: F1SAN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SLC25A36
gene id: 9823:SLC25A36
uniprot id: A0A8D0SP01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:KRT5
gene id: 9823:KRT5
uniprot id: F1SGG6
names: Similarity
messages: Belongs to the intermediate filament family.

9823:IL23A
gene id: 9823:IL23A
uniprot id: C8KIR2
uniprot id: Q9N2H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23. Interacts with IL23R; this interaction enables recruitment of IL12RB1.
messages: Secreted

9823:CERS3
gene id: 9823:CERS3
uniprot id: A0A4X1UI88
uniprot id: A0A8D1CCZ6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9823:RASGRP2
gene id: 9823:RASGRP2
uniprot id: A0A8D1TSW8
names: Similarity
messages: Belongs to the RASGRP family.

9823:TSSK1B
gene id: 9823:TSSK1B
uniprot id: A0A8D0SR93
uniprot id: F1RK80
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:RASGRP1
gene id: 9823:RASGRP1
uniprot id: A0A287BSC2
uniprot id: A0A4X1ULG6
names: Similarity
messages: Belongs to the RASGRP family.

9823:WASHC1
gene id: 9823:WASHC1
uniprot id: A0A480TN39
uniprot id: A0A4X1ULF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WASH1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Recycling endosome membrane

9823:INTS3
gene id: 9823:INTS3
uniprot id: A0A8D1BLI5
uniprot id: F1SFW4
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

9823:LOC100516963
gene id: 9823:LOC100516963
uniprot id: A0A4X1VTC7
uniprot id: F1RHM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ZC3H12B
gene id: 9823:ZC3H12B
uniprot id: A0A4X1VPU5
uniprot id: F1RTN0
names: Similarity
messages: Belongs to the ZC3H12 family.

9823:DOK2
gene id: 9823:DOK2
uniprot id: A0A480V4P5
uniprot id: A0A8D0JZB7
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9823:PRSS36
gene id: 9823:PRSS36
uniprot id: A0A8D1BPK4
uniprot id: F1RIS0
names: Function
names: Subcellular Location Annotation
messages: Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1.
messages: extracellular matrix

9823:GPNMB
gene id: 9823:GPNMB
uniprot id: A0A4X1T4E9
uniprot id: A5A766
names: Similarity
messages: Belongs to the PMEL/NMB family.

9823:NECTIN1
gene id: 9823:NECTIN1
uniprot id: Q9GL76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nectin family.
messages: Cell membrane
messages: Interacts with HSV glycoprotein D (gD).
messages: Probably involved in cell adhesion. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells.

9823:KCND3
gene id: 9823:KCND3
uniprot id: A0A4X1T8H8
uniprot id: A0A8D1LA13
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

9823:CLDN18
gene id: 9823:CLDN18
uniprot id: A0A8D1JJ57
uniprot id: C3VMW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9823:PIGC
gene id: 9823:PIGC
uniprot id: A0A8D0SHR8
uniprot id: D0G788
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9823:FAR1
gene id: 9823:FAR1
uniprot id: A0A4X1TLN7
uniprot id: A0A8D0KKB9
uniprot id: A0A8D1S2D8
uniprot id: G8ENM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9823:GLP1R
gene id: 9823:GLP1R
uniprot id: A0A4X1SP80
uniprot id: F1RVR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9823:PLCD1
gene id: 9823:PLCD1
uniprot id: A0A480F1A1
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9823:IFN-DELTA-6
gene id: 9823:IFN-DELTA-6
uniprot id: A0A4X1WDG0
uniprot id: C8CKB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:BLM
gene id: 9823:BLM
uniprot id: B0M1M9
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9823:NCBP2
gene id: 9823:NCBP2
uniprot id: A0A8D1PJS1
uniprot id: F2Z5Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9823:KCNK1
gene id: 9823:KCNK1
uniprot id: A0A4X1UHG4
uniprot id: F1RGV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

9823:FA2H
gene id: 9823:FA2H
uniprot id: A0A480VWF2
uniprot id: A0A4X1SSW8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:CAV3
gene id: 9823:CAV3
uniprot id: Q3ZDQ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Expressed specifically in skeletal muscle and heart.
messages: Golgi apparatus membrane
messages: Homooligomer. Interacts with DYSF. Interacts with DLG1 and KCNA5; forms a ternary complex. Interacts with DAG1 (via its C-terminal); the interaction prevents binding of DAG1 with DMD. Interacts with TRIM72. Interacts with MUSK; may regulate MUSK signaling. Interacts with BVES. Interacts with CAVIN1, CAVIN2 and CAVIN4.
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.
messages: Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.
messages: caveola
messages: sarcolemma

9823:HMGB1
gene id: 9823:HMGB1
uniprot id: A0A4X1TJK2
uniprot id: A0A8D1RRK7
uniprot id: P12682
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on multiple sites upon stimulation with LPS (By similarity). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion. Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity.
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Endosome
messages: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.
messages: HMG box 2 mediates pro-inflammatory cytokine-stimulating activity and binding to TLR4. However, not involved in mediating immunogenic activity in the context of apoptosis-induced immune tolerance.
messages: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity).
messages: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization. Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM. Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE. Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways (PubMed:14660645). Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10. Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2. In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes. Contributes to tumor proliferation by association with ACER/RAGE. Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex. Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin imm…
messages: In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance. Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and pro-inflammatory activities (By similarity).
messages: Interacts (fully reduced HMGB1) with CXCL12; probably in a 1:2 ratio involving two molecules of CXCL12, each interacting with one HMG box of HMGB1; inhibited by glycyrrhizin. Associates with the TLR4:LY96 receptor complex. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Interacts (in cytoplasm upon starvation) with BECN1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with KPNA1; involved in nuclear import. Interacts with SREBF1, TLR2, TLR4, TLR9, PTPRZ1, APEX1, FEN1, POLB, TERT. Interacts with IL1B, AGER, MSH2, XPA, XPC, HNF1A, TP53. Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with THBD; prevents HGMB1 interaction with ACER/RAGE and inhibits HGMB1 pro-inflammatory activity. Interacts with HAVCR2; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response. Interacts with XPO1; mediating nuclear export. Interacts with receptor RAGE/AGER (By similarity).
messages: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins (By similarity).
messages: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). In vitro can displace histone H1 from highly bent DNA. Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding. Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities. Facilitates binding of TP53 to DNA. May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1. Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). Represses porcine circovirus type 2 replication within the nucleus by binding to the Ori region of the viral genome (PubMed:32321806).
messages: Nucleus
messages: Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion (By similarity). Phosphorylation at Thr-51 within the NLS is crucial for secretion induced by porcine reproductive and respiratory syndrome virus (PRRSV)(PubMed:35632744).
messages: Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS.
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).
messages: Secreted
messages: The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins.

9823:GMFG
gene id: 9823:GMFG
uniprot id: A0A4X1SWK9
uniprot id: A0A8D1DBZ1
uniprot id: F1SEH2
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9823:CCL3L1
gene id: 9823:CCL3L1
uniprot id: Q6DUK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:TMED2
gene id: 9823:TMED2
uniprot id: A0A8D2C4M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9823:PRDM1
gene id: 9823:PRDM1
uniprot id: A0A287BLU1
uniprot id: A0A4X1VA80
uniprot id: A0A4X1VE21
uniprot id: A0A4X1VE26
uniprot id: F1RYP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9823:ARHGDIA
gene id: 9823:ARHGDIA
uniprot id: A0A8D0VGV2
uniprot id: E7EI20
names: Similarity
messages: Belongs to the Rho GDI family.

9823:LPGAT1
gene id: 9823:LPGAT1
uniprot id: A0A8D0T3Y6
uniprot id: F1S2U6
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9823:ATE1
gene id: 9823:ATE1
uniprot id: A0A287BP37
uniprot id: A0A480M856
uniprot id: A0A5G2RH42
uniprot id: A0A8D0ZJW3
uniprot id: A0A8D0ZNV4
uniprot id: A0A8D1CSL7
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9823:AZIN2
gene id: 9823:AZIN2
uniprot id: A0A8D1VWG4
uniprot id: B2CRH7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9823:CASTOR1
gene id: 9823:CASTOR1
uniprot id: A0A4X1VBI5
uniprot id: A0A4X1VCG3
uniprot id: A0A8D0SLA8
uniprot id: A0A8D1P7I0
names: Similarity
messages: Belongs to the GATS family.

9823:FMO5
gene id: 9823:FMO5
uniprot id: A0A4X1SM21
uniprot id: A0A8D0STF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9823:BEND6
gene id: 9823:BEND6
uniprot id: A0A8D1NVL0
uniprot id: F1RZU9
names: Subcellular Location Annotation
messages: Nucleus

9823:UTP3
gene id: 9823:UTP3
uniprot id: B7TJ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAS10 family.
messages: nucleolus

9823:CYBRD1
gene id: 9823:CYBRD1
uniprot id: A0A8D0TVG5
uniprot id: B2ZPK1
names: Subcellular Location Annotation
messages: Membrane

9823:KCNK5
gene id: 9823:KCNK5
uniprot id: A0A8D1T572
uniprot id: F1RVQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9823:NSUN7
gene id: 9823:NSUN7
uniprot id: A0A480DIN4
uniprot id: A0A4X1UYU7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:FDXR
gene id: 9823:FDXR
uniprot id: A0A480IMK2
uniprot id: A0A8D0V9S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

9823:LOC100621915
gene id: 9823:LOC100621915
uniprot id: A0A480RS85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:HIGD2A
gene id: 9823:HIGD2A
uniprot id: A1XQS4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9823:PLLP
gene id: 9823:PLLP
uniprot id: A0A4X1SDQ5
uniprot id: A0A8D1U654
names: Subcellular Location Annotation
messages: Membrane

9823:MCMBP
gene id: 9823:MCMBP
uniprot id: A0A480WXM5
uniprot id: A0A8D1C0Z1
uniprot id: F1S413
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

9823:GDI2
gene id: 9823:GDI2
uniprot id: Q6Q7J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A.
messages: Interacts with RHOH. Interacts with the GDP-bound forms of RAB3A, RAB3B, RAB3C, RAB5A, RAB5B, RAB5C, RAB8B, RAB10, RAB12, RAB35, and RAB43; binds RAB3D to a lesser extent. Interacts with RAB8A (GDP-bound inactive form); prevents RAB8A activation. Interacts with DZIP1; negatively regulates the interaction of GDI2 with GDP-bound RAB8A.
messages: Membrane

9823:MAGI3
gene id: 9823:MAGI3
uniprot id: A0A287BIU8
uniprot id: A0A4X1T4I1
uniprot id: A0A4X1T4L8
uniprot id: A0A5G2QTS3
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100623441
gene id: 9823:LOC100623441
uniprot id: A0A8D1PZR9
uniprot id: I3LC84
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:LOC100620101
gene id: 9823:LOC100620101
uniprot id: A0A286ZQT8
uniprot id: A0A8D2C9K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TLR5
gene id: 9823:TLR5
uniprot id: A0A8D1CXZ2
uniprot id: C0L925
uniprot id: Q59HI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9823:SCNN1A
gene id: 9823:SCNN1A
uniprot id: Q6TM04
names: Subcellular Location Annotation
messages: Membrane

9823:DLX5
gene id: 9823:DLX5
uniprot id: A8ILX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9823:SENP7
gene id: 9823:SENP7
uniprot id: A0A287A2Z8
uniprot id: A0A287A739
uniprot id: A0A4X1UX12
uniprot id: A0A8D0JPD0
uniprot id: A0A8D0LR97
uniprot id: A0A8D1TIF2
uniprot id: A0A8D2BFW9
uniprot id: I3LG40
names: Similarity
messages: Belongs to the peptidase C48 family.

9823:POLR2G
gene id: 9823:POLR2G
uniprot id: A0A4X1VKG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9823:TPST2
gene id: 9823:TPST2
uniprot id: A0A4X1SIB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9823:TMEM151A
gene id: 9823:TMEM151A
uniprot id: A0A4X1TSM4
uniprot id: F1RU42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9823:ANKH
gene id: 9823:ANKH
uniprot id: A0A480XL82
uniprot id: A0A4X1TLB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

9823:FLAD1
gene id: 9823:FLAD1
uniprot id: A0A286ZN22
uniprot id: A0A8D1VX30
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9823:LOC100737597
gene id: 9823:LOC100737597
uniprot id: A0A4X1T8H3
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9823:UTP11
gene id: 9823:UTP11
uniprot id: A0A8D0WLH0
uniprot id: F1SV29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9823:TMOD2
gene id: 9823:TMOD2
uniprot id: A0A287BG70
uniprot id: A0A4X1T3P0
uniprot id: A0A8D0QY88
names: Subcellular Location Annotation
messages: cytoskeleton

9823:SPDYA
gene id: 9823:SPDYA
uniprot id: Q4R1K5
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9823:RP2
gene id: 9823:RP2
uniprot id: A0A480E0X6
uniprot id: A0A4X1VJZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9823:REEP3
gene id: 9823:REEP3
uniprot id: A0A287ARX4
uniprot id: A0A4X1TSY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9823:OPTN
gene id: 9823:OPTN
uniprot id: A0A4X1VXX3
uniprot id: A0A8D1IYN0
uniprot id: A0A8D1PED0
uniprot id: Q7YS99
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasmic vesicle
messages: Down-regulated upon treatment with dexamethasone. Not regulated by hypoxic conditions.
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection.
messages: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
messages: Present in aqueous humor of the eye (at protein level). Expressed in trabecular meshwork and astrocytes.
messages: Recycling endosome
messages: Self-associates (By similarity). Interacts with HD, GTF3A, TRAF3, TBK1 and MYO6. Interacts (via UBAN) with ubiquitinated TFRC. Interacts with active GTP-bound Rab8 (RAB8A and/or RAB8B). Interacts with TBC1D17. Binds to linear ubiquitin chains. Interacts with LC3 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2; OPTN phosphorylation increases the association (at least with MAP1LC3B). Interacts with RAB12; the interaction may be indirect (By similarity). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction does not lead to palmitoylation of OPTN (By similarity). Interacts with CYLD (By similarity). Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and OPTN (By similarity).
messages: The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.
messages: Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

9823:CRYBB1
gene id: 9823:CRYBB1
uniprot id: Q007T1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).
messages: Specific cleavages in the N-terminal arm occur during lens maturation and give rise to truncated forms, leading to impaired oligomerization and protein insolubilization.

9823:HNMT
gene id: 9823:HNMT
uniprot id: A0A287AA45
uniprot id: A0A4X1SYB7
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9823:SLC29A1
gene id: 9823:SLC29A1
uniprot id: A0A8D1I3Q2
uniprot id: A0A8D1L104
uniprot id: A0A8D1UUL4
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

9823:NELFCD
gene id: 9823:NELFCD
uniprot id: A0A480NDK8
uniprot id: A5GFY4
uniprot id: K7GPN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NELF-D family.
messages: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity).
messages: Nucleus
messages: The NELF complex is composed of NELFA, NELFB, NELFCD and NELFE; NELFA and NELFCD form a stable subcomplex that binds primarily through NELFCD to the N-terminus of NELFB (By similarity). Binds RNA which may help to stabilize the NELF complex on nucleic acid (By similarity). In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner (By similarity). Interacts with ARAF1 (By similarity). Interacts with PCF11 (By similarity). Interacts with NELFB (By similarity). Interacts with KAT8 (By similarity).

9823:SST
gene id: 9823:SST
uniprot id: P01168
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the somatostatin family.
messages: C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure.
messages: Expressed in the pancreas and the spleen (at protein level).
messages: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.
messages: May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (By similarity).
messages: Secreted

9823:LEP
gene id: 9823:LEP
uniprot id: C7EDV4
uniprot id: Q29406
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP…
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

9823:PTPN21
gene id: 9823:PTPN21
uniprot id: A0A8D1CU08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9823:BFSP2
gene id: 9823:BFSP2
uniprot id: F1SLB0
names: Similarity
messages: Belongs to the intermediate filament family.

9823:FRG1
gene id: 9823:FRG1
uniprot id: A0A4X1U2Z7
uniprot id: A0A8D0NPQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

9823:RAB39A
gene id: 9823:RAB39A
uniprot id: A0A287A5W5
uniprot id: A0A4X1VI77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9823:BTNL9
gene id: 9823:BTNL9
uniprot id: A0A8D0YN28
uniprot id: I3LLH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9823:TMEM168
gene id: 9823:TMEM168
uniprot id: A0A4X1W654
uniprot id: A0A8D0XJI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane
messages: Nucleus membrane

9823:ASIP
gene id: 9823:ASIP
uniprot id: A0A8D1HAG1
uniprot id: I3W8V4
uniprot id: Q6ZYM3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
messages: Secreted
messages: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

9823:ENG
gene id: 9823:ENG
uniprot id: P37176
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer; disulfide-linked. Forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGFB1 and TGFB2 with high affinity, but not TGFB3 (PubMed:8294451). Interacts with GDF2, forming a heterotetramer with a 2:2 stoichiometry. Interacts with ACVRL1. Can form a heteromeric complex with GDF2 and ACVRL1. Interacts with BMP10. Interacts with DYNLT4. Interacts with ARRB2 (By similarity).
messages: Lacks a RGD motif, contrary to the human protein.
messages: The N-terminal OR region is composed of two intertwined domains (OR1 and OR2) with a common, novel fold. Each contains 12 beta-strands that form a parallel beta-helix-like structure, plus a single alpha-helix. The OR1 region mediates interaction with GDF2.
messages: The ZP domain mediates dimerization.
messages: Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to integrins (By similarity). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8294451). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity).

9823:RPL22
gene id: 9823:RPL22
uniprot id: P67985
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL22 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9823:LOC100151929
gene id: 9823:LOC100151929
uniprot id: A0A4X1SRS0
uniprot id: F1S964
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:AGO1
gene id: 9823:AGO1
uniprot id: A0A8D0RXU0
uniprot id: A0A8D0ZC34
uniprot id: D9YJ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9823:LCLAT1
gene id: 9823:LCLAT1
uniprot id: A0A4X1TGC3
uniprot id: B7U2H0
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9823:SLC1A1
gene id: 9823:SLC1A1
uniprot id: A0A4X1W8W1
uniprot id: F1SK41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9823:CCL21
gene id: 9823:CCL21
uniprot id: Q6EKW3
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9823:TFCP2L1
gene id: 9823:TFCP2L1
uniprot id: A0A4X1SFL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9823:ACTA2
gene id: 9823:ACTA2
uniprot id: A0A8D0IP73
uniprot id: C7AI81
names: Similarity
messages: Belongs to the actin family.

9823:BTG1
gene id: 9823:BTG1
uniprot id: A0A4X1SGU2
uniprot id: A5YRP0
names: Similarity
messages: Belongs to the BTG family.

9823:CDK4
gene id: 9823:CDK4
uniprot id: P79432
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Both phosphorylation at Thr-172 and binding of a D-type cyclin are necessary for enzymatic activity. Full activation of the cyclin-D-CDK4 complex appears to require other factors such as recruitment of the substrate via a substrate recruitment motif, and/or formation of the CDKN1B ternary complex. Inhibited by INK4 family members. In resting cells, the non-tyrosine-phosphorylated form of CDKN1B prevents phosphorylation at Thr-172 and inactivation, while, in proliferating cells, tyrosine phosphorylation of CDKN1B allows phosphorylation of Thr-172 of CDK4 and subsequent activation.
messages: Component of the D-CDK4 complex, composed of CDK4 and some D-type G1 cyclin (CCND1, CCND2 or CCND3). Interacts directly in the complex with CCND1, CCND2 or CCND3. Interacts with SEI1 and ZNF655. Forms a ternary complex, cyclin D-CDK4-CDKN1B, involved in modulating CDK4 enzymatic activity. Interacts directly with CDKN1B (phosphorylated on 'Tyr-88' and 'Tyr-89'); the interaction allows assembly of the cyclin D-CDK4 complex, Thr-172 phosphorylation, nuclear translocation and enhances the cyclin D-CDK4 complex activity. CDK4 activity is either inhibited or enhanced depending on stoichiometry of complex. The non-tyrosine-phosphorylated form of CDKN1B prevents T-loop phosphorylation of CDK4 producing inactive CDK4. Interacts (unphosphorylated form) with CDK2. Also forms ternary complexes with CDKN1A or CDKN2A. Interacts directly with CDKN1A (via its N-terminal); the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Interacts with CCND1; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23. Interacts with CEBPA (when phosphorylated). Interacts with FNIP1 and FNIP2.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus membrane
messages: Phosphorylation at Thr-172 is required for enzymatic activity. Phosphorylated, in vitro, at this site by CCNH-CDK7, but, in vivo, appears to be phosphorylated by a proline-directed kinase. In the cyclin D-CDK4-CDKN1B complex, this phosphorylation and consequent CDK4 enzyme activity, is dependent on the tyrosine phosphorylation state of CDKN1B. Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the T-loop. In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of CDKN1B (By similarity).
messages: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

9823:AKIRIN2
gene id: 9823:AKIRIN2
uniprot id: A0A287BDC1
uniprot id: A0A4X1VIF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the akirin family.
messages: Cytoplasm
messages: Homodimer. Interacts with IPO9; the interaction is direct. Associates with 20S and 26S proteasomes (By similarity). Interacts with SMARCD1; promoting SWI/SNF complex recruitment. Interacts with NFKBIZ (By similarity). Interacts with YWHAB (By similarity).
messages: Membrane
messages: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (By similarity). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (PubMed:25686036, PubMed:28327665).
messages: Nucleus
messages: Widely expressed (PubMed:22537061). Most abundant in the lung, followed by the skeletal muscle, heart, liver, fat, thymus, lymph node, small intestine, kidney and spleen (PubMed:22537061). In skeletal muscle, expressed at higher level in fast extensor digitorum longus (EDL) and longissimus lumborum (LL) muscles than in slow soleus (SOL) muscles (PubMed:25686036).

9823:PALMD
gene id: 9823:PALMD
uniprot id: A0A480JY98
uniprot id: Q2MJV9
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the paralemmin family.
messages: Cytoplasm
messages: Interacts with GLUL (By similarity). Cell projection, dendrite. Cell projection, dendritic spine (By similarity).
messages: Phosphorylated.
messages: dendrite
messages: dendritic spine

9823:LEPR
gene id: 9823:LEPR
uniprot id: O02671
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Kidney, liver, spleen, lung, brain, testis, uterus, ovary, corpus luteum, theca and granulosa cells.
messages: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. Phosphorylation of Tyr-1079 has a more accessory role.
messages: Present as a mixture of monomers and dimers. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3 (By similarity). Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade (By similarity).
messages: Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (By similarity). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.

9823:SSTR3
gene id: 9823:SSTR3
uniprot id: A0A4X1ULT4
uniprot id: A0A8D0PP89
uniprot id: I3LL93
uniprot id: Q6YEX9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:BLVRA
gene id: 9823:BLVRA
uniprot id: A0A480V8U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
messages: Monomer.
messages: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
messages: cytosol

9823:GRIA4
gene id: 9823:GRIA4
uniprot id: A0A480ECV5
uniprot id: A0A4X1THI5
uniprot id: A0A4X1TLY6
uniprot id: A0A8D0JZP4
uniprot id: A0A8D1EB35
uniprot id: A0A8D1QA73
uniprot id: A0A8D1QAD2
uniprot id: A0A8D1VTW1
uniprot id: A0A8D1X8M6
uniprot id: I3L8N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9823:ADI1
gene id: 9823:ADI1
uniprot id: A0A8D1CG10
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

9823:C7
gene id: 9823:C7
uniprot id: Q9TUQ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: C- and N-glycosylated.
messages: C7 has 28 disulfide bridges.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.
messages: Detected in plasma (at protein level). Bone marrow, heart, intestine, lung, spleen, kidney, liver and thymus.
messages: Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes. MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).
messages: Secreted

9823:C2H11orf68
gene id: 9823:C2H11orf68
uniprot id: A0A8D2BT85
uniprot id: F1RU27
names: Similarity
messages: Belongs to the UPF0696 family.

9823:ADAM22
gene id: 9823:ADAM22
uniprot id: A0A287AU50
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LHFPL1
gene id: 9823:LHFPL1
uniprot id: A0A8D0XPY8
uniprot id: F1RWT8
names: Subcellular Location Annotation
messages: Membrane

9823:PDIA3
gene id: 9823:PDIA3
uniprot id: A0A8D0IPP9
uniprot id: E1CAJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9823:ANKS1A
gene id: 9823:ANKS1A
uniprot id: F8SIP9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9823:KCNJ1
gene id: 9823:KCNJ1
uniprot id: A0A8D0HQP9
uniprot id: A0A8D1DW95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9823:PSMA3
gene id: 9823:PSMA3
uniprot id: A0A8D1ZB41
uniprot id: F1SSL6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9823:DCAF13
gene id: 9823:DCAF13
uniprot id: A0A480V443
uniprot id: A0A8D1RCH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

9823:MED17
gene id: 9823:MED17
uniprot id: A0A4X1TVK2
uniprot id: A0A8D0XVA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:PDK4
gene id: 9823:PDK4
uniprot id: A0A8D1RMF6
uniprot id: C1IHT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9823:SV2B
gene id: 9823:SV2B
uniprot id: A0A4X1UER6
uniprot id: A0A8D1G9T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9823:COG8
gene id: 9823:COG8
uniprot id: A0A4X1SFA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG8 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:DECR2
gene id: 9823:DECR2
uniprot id: A0A4X1UK46
uniprot id: A0A4X1UNX2
uniprot id: A0A8D0KGB1
uniprot id: A0A8D1FXH8
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

9823:MTFMT
gene id: 9823:MTFMT
uniprot id: A0A4X1U587
uniprot id: F1S1X2
names: Similarity
messages: Belongs to the Fmt family.

9823:WNT8B
gene id: 9823:WNT8B
uniprot id: A0A4X1TZ80
uniprot id: A0A8D0SKN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:RFLNA
gene id: 9823:RFLNA
uniprot id: A0A4X1UJ62
uniprot id: A0A5G2QSA2
uniprot id: A0A8D1UKA7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9823:CASP14
gene id: 9823:CASP14
uniprot id: A0A8D0ULZ6
uniprot id: F1SAN1
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:ARRB1
gene id: 9823:ARRB1
uniprot id: A0A286ZZD7
uniprot id: A0A480TT90
uniprot id: A0A8D0N667
uniprot id: A0A8D0S8Q0
uniprot id: A0A8D1RNJ6
names: Similarity
messages: Belongs to the arrestin family.

9823:DCTN3
gene id: 9823:DCTN3
uniprot id: F1SEC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynactin subunit 3 family.
messages: Cleavage furrow
messages: Cytoplasm
messages: Midbody
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (PubMed:33734450, PubMed:36071160). Together with dynein is involved in spindle assembly and cytokinesis (By similarity).
messages: Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3 (PubMed:33734450, PubMed:36071160). The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6 (PubMed:33734450). The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin (PubMed:33734450, PubMed:36071160).
messages: centrosome
messages: cytoskeleton
messages: kinetochore
messages: spindle

9823:INHBB
gene id: 9823:INHBB
uniprot id: P04088
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity).
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9823:LOC106506651
gene id: 9823:LOC106506651
uniprot id: A0A287A2G9
uniprot id: A0A4X1WBW9
names: Similarity
messages: Belongs to the intermediate filament family.

9823:FBLN7
gene id: 9823:FBLN7
uniprot id: A0A4X1VFY2
uniprot id: F1SUA0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CD109
gene id: 9823:CD109
uniprot id: A0A8D1AXL6
uniprot id: K7GKY0
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

9823:SDHAF2
gene id: 9823:SDHAF2
uniprot id: A0A8D0XRJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9823:TARS2
gene id: 9823:TARS2
uniprot id: A0A480WLU7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9823:FAM46A
gene id: 9823:FAM46A
uniprot id: A0A4X1V4L2
uniprot id: F1RQL4
names: Similarity
messages: Belongs to the TENT family.

9823:RPL22L1
gene id: 9823:RPL22L1
uniprot id: A0A4X1V8X4
uniprot id: A0A8D1LX87
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9823:OAS2
gene id: 9823:OAS2
uniprot id: A0A8D1TDW8
uniprot id: Q56VQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9823:PIGL
gene id: 9823:PIGL
uniprot id: A0A4X1SRG8
uniprot id: A0A5G2RER5
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

9823:MRPL47
gene id: 9823:MRPL47
uniprot id: A0A4X1V3N8
uniprot id: A0A8D0YZW0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9823:SLC28A1
gene id: 9823:SLC28A1
uniprot id: O62667
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Cell membrane
messages: Due to its high apparent affinity but slow transport, adenosine could act as a negative regulator of pyrimidine transport under some conditions.
messages: N-glycosylated. N-glycosylation is required for localization to the plasma membrane and the transporter activity.
messages: Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity. Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit). Involved in renal nucleoside (re)absorption.

9823:LOC100621287
gene id: 9823:LOC100621287
uniprot id: A0A4X1SME5
uniprot id: A0A8D2CAJ9
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9823:LOC100517830
gene id: 9823:LOC100517830
uniprot id: A0A287BP72
names: Similarity
messages: Belongs to the PRAME family.

9823:CSRNP1
gene id: 9823:CSRNP1
uniprot id: A0A8D2AC51
uniprot id: F1SJR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9823:SIX4
gene id: 9823:SIX4
uniprot id: A0A286ZV22
uniprot id: A0A4X1W7E9
names: Subcellular Location Annotation
messages: Nucleus

9823:KEF22 p05
gene id: 9823:KEF22_p05
uniprot id: P56632
uniprot id: Q7IIB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9823:FDX1
gene id: 9823:FDX1
uniprot id: P00258
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adrenodoxin/putidaredoxin family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons.
messages: Interacts with CYP11A1.
messages: Mitochondrion matrix

9823:HAPLN1
gene id: 9823:HAPLN1
uniprot id: A0A8D0I7T0
uniprot id: F1REZ1
uniprot id: P10859
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAPLN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
messages: extracellular matrix

9823:FGF20
gene id: 9823:FGF20
uniprot id: A0A4X1TU89
uniprot id: G0ZMB9
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:ARAF
gene id: 9823:ARAF
uniprot id: O19004
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Interacts with TH1L/NELFD.
messages: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). Phosphorylates PFKFB2 (By similarity).

9823:HADH
gene id: 9823:HADH
uniprot id: A0A480WX09
uniprot id: P00348
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Homodimer (PubMed:3479790, PubMed:9593854). Interacts with GLUD1; this interaction inhibits the activation of glutamate dehydrogenase 1 (GLUD1) (By similarity).
messages: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:9593854, PubMed:2817332). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity).
messages: Mitochondrion matrix
messages: Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5.

9823:HIF1A
gene id: 9823:HIF1A
uniprot id: A0T1H6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:TNS4
gene id: 9823:TNS4
uniprot id: A0A8D0S2E2
uniprot id: F1RXE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9823:LSM2
gene id: 9823:LSM2
uniprot id: A0A4X1V9D9
uniprot id: A5A8V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

9823:GNPAT
gene id: 9823:GNPAT
uniprot id: A0A8D0S8C1
uniprot id: D0G6X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9823:ERC1
gene id: 9823:ERC1
uniprot id: A0A8D0M9C5
names: Subcellular Location Annotation
messages: Cytoplasm

9823:C5AR2
gene id: 9823:C5AR2
uniprot id: A0A5G2QHE8
uniprot id: A0A8D1FJQ6
uniprot id: A0A8D1WQF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

9823:OTOP2
gene id: 9823:OTOP2
uniprot id: A0A4X1SFQ1
uniprot id: A0A8D0TP05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9823:RPL7
gene id: 9823:RPL7
uniprot id: A8YQT9
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9823:EIF2S1
gene id: 9823:EIF2S1
uniprot id: A0A4X1U4D4
uniprot id: A0A4X1U6Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9823:PFKM
gene id: 9823:PFKM
uniprot id: Q2HYU2
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: GlcNAcylation decreases enzyme activity.
messages: Homo- and heterotetramers (By similarity). Phosphofructokinase (PFK) enzyme functions as a tetramer composed of different combinations of 3 types of subunits, called PFKM (M), PFKL (L) and PFKP (P). The composition of the PFK tetramer differs according to the tissue type it is present in. The kinetic and regulatory properties of the tetrameric enzyme are dependent on the subunit composition, hence can vary across tissues (Probable). Interacts (via C-terminus) with HK1 (via N-terminal spermatogenic cell-specific region) (By similarity).

9823:IAPP
gene id: 9823:IAPP
uniprot id: A0A480NY05
uniprot id: A0A4X1VGM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted
messages: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

9823:SLC22A2
gene id: 9823:SLC22A2
uniprot id: O02713
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basal cell membrane
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Contains one proline-rich sequence (Pro-Glu-Ser-Pro-Arg) that may be involved in tyrosine-protein kinase YES1 binding and is required for the activation of substrate transport.
messages: Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Functions as a Na(+)-independent, bidirectional uniporter. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (By similarity). However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (By similarity). Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow. Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters. Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system. Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium. Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1-methylnicotinamide (NMN). Mediates the uptake and efflux of quaternary ammonium compound choline. Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamines putrescine and spermidine. Able to transport non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha). Also involved in the uptake of xenobiotic 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP). May contribute to regulate the transport of organic co…
messages: Mediates the renal secretion of many clinically used cationic drugs. Transports drugs such as diabetes treatment medicine metformin and neurotoxins 1-methyl-4-phenylpyridinium (MPP(+)), famotidine, ranitidine, amantadine, acriflavine, amiloride, memantine, cimetidine, cisplatin, oxaliplatin, platinum-based drugs cisplatin and oxaliplatin, 3'-azido-3'-deoxythymidine (AZT) and tetraethylammonium (TEA). Mediates the bidirectional transport of MPP(+). Metformin competitively inhibits OCT1-mediated thiamine uptake, leading to a decrease in hepatic steatosis. Plays a predominant role in the anticancer activity of cisplatin and oxaliplatin and may contribute to antitumor specificity (By similarity). Involved in cisplatin-induced nephrotoxicity (By similarity).
messages: Tyrosine phosphorylated.
messages: Tyrosine phosphorylation of the transporter leads to activation of the transport activity. Inhibited by cGMP, most likely through a cGMP-binding protein that interacts with OCT2.
messages: While most authors have deduced a localization at the basolateral membrane of proximal tubules, other studies demonstrated a localization to the luminal membrane in the distal tubule.

9823:NAPSA
gene id: 9823:NAPSA
uniprot id: A0A287AH87
uniprot id: A0A8D0IXX3
names: Similarity
messages: Belongs to the peptidase A1 family.

9823:BLCAP
gene id: 9823:BLCAP
uniprot id: A0A4X1THT8
uniprot id: A0A8W4FKJ0
names: Similarity
messages: Belongs to the BLCAP family.

9823:EBF1
gene id: 9823:EBF1
uniprot id: A0A286ZSS0
uniprot id: A0A4X1TX79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9823:FADS3
gene id: 9823:FADS3
uniprot id: A0A8D0ZT88
uniprot id: D2D0E5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9823:RTN4IP1
gene id: 9823:RTN4IP1
uniprot id: A0A4X1VG46
uniprot id: A0A5K1VV69
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9823:NIFK
gene id: 9823:NIFK
uniprot id: A7E1T9
names: Subcellular Location Annotation
messages: nucleolus

9823:LOC100525679
gene id: 9823:LOC100525679
uniprot id: A0A8D1S9I8
uniprot id: K7GP63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9823:DPP4
gene id: 9823:DPP4
uniprot id: A0A480UDQ9
uniprot id: P22411
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell junction
messages: Cell membrane
messages: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:14719797). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity).
messages: Inhibited by GPC3 and diprotin A.
messages: Membrane raft
messages: Monomer. Homodimer (PubMed:12690074). Heterodimer with Seprase (FAP) (By similarity). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation (By similarity). Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (By similarity). Associates with collagen (By similarity). Interacts with PTPRC; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes (By similarity). Interacts (via extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity (By similarity). Interacts with CAV1 (via the N-terminus); the interaction is direct (By similarity). Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11 (By similarity). Interacts with IGF2R; the interaction is direct (By similarity). Interacts with GPC3 (By similarity).
messages: N- and O-Glycosylated.
messages: Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation (By similarity).
messages: Secreted
messages: The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.
messages: invadopodium membrane
messages: lamellipodium membrane

9823:SERPINA3-2
gene id: 9823:SERPINA3-2
uniprot id: Q9GMA6
names: Similarity
messages: Belongs to the serpin family.

9823:ASIC3
gene id: 9823:ASIC3
uniprot id: A0A8D1YS29
names: Subcellular Location Annotation
messages: Membrane

9823:YOD1
gene id: 9823:YOD1
uniprot id: A0A480ZEB3
uniprot id: A0A8D0LEQ2
uniprot id: F1RTR7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

9823:TFB1M
gene id: 9823:TFB1M
uniprot id: B2MUB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

9823:PI4KB
gene id: 9823:PI4KB
uniprot id: A0A4X1W0B2
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9823:MYOG
gene id: 9823:MYOG
uniprot id: P49812
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).
messages: Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts (via C-terminal region) with SSRP1 and SUPT16H; the interaction is indicative of an interaction with the FACT complex. Interacts with CSRP3 (By similarity).
messages: Nucleus
messages: Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles (By similarity).

9823:PSMB3
gene id: 9823:PSMB3
uniprot id: A0A286ZN52
uniprot id: A0A8D0S700
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9823:TRAM1
gene id: 9823:TRAM1
uniprot id: A0A481D5U0
uniprot id: A0A4X1UPH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9823:ANKRD13C
gene id: 9823:ANKRD13C
uniprot id: A0A4X1U755
uniprot id: F1S834
names: Subcellular Location Annotation
messages: Membrane

9823:OAS1
gene id: 9823:OAS1
uniprot id: Q29599
uniprot id: Q5MX78
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
messages: Microsome
messages: Mitochondrion
messages: Monomer. Homotetramer (By similarity).
messages: Nucleus
messages: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators (By similarity).
messages: Secreted

9823:DDX31
gene id: 9823:DDX31
uniprot id: A0A8D1ICL8
uniprot id: F1S0U0
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9823:SLC25A5
gene id: 9823:SLC25A5
uniprot id: A0A4X1W7H9
uniprot id: F2Z565
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9823:SERPINA5
gene id: 9823:SERPINA5
uniprot id: A0A4X1SGC6
uniprot id: A0A8D0Y9U8
names: Similarity
messages: Belongs to the serpin family.

9823:RNF182
gene id: 9823:RNF182
uniprot id: A0A480DHP1
uniprot id: A0A8D0SAS8
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9823:C13H21orf59
gene id: 9823:C13H21orf59
uniprot id: A0A4X1U411
uniprot id: A0A8D1MUL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9823:COX6B
gene id: 9823:COX6B
uniprot id: A0A4X1TG97
uniprot id: A0A8D0W345
uniprot id: A1XQT1
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9823:CNTN1
gene id: 9823:CNTN1
uniprot id: A0A287B9Q3
uniprot id: A0A4X1U3Q4
uniprot id: A0A8D1A8J6
uniprot id: F1SHN1
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9823:CDC5L
gene id: 9823:CDC5L
uniprot id: A0A8D0USH3
uniprot id: F1RQS5
names: Similarity
messages: Belongs to the CEF1 family.

9823:BLOC1S6
gene id: 9823:BLOC1S6
uniprot id: A0A8D0M7G8
uniprot id: A5A778
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9823:PMAP-36
gene id: 9823:PMAP-36
uniprot id: P49931
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Exerts antimicrobial activity against both Gram-positive and negative bacteria. Its activity appears to be mediated by its ability to damage bacterial membranes.
messages: Secreted

9823:EFHB
gene id: 9823:EFHB
uniprot id: A0A8D1W322
uniprot id: F1RS61
names: Subcellular Location Annotation
messages: cilium axoneme

9823:IL10
gene id: 9823:IL10
uniprot id: B5D5P9
uniprot id: Q29055
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-10 family.
messages: Homodimer. Interacts with IL10RA and IL10RB.
messages: Immune regulatory cytokine.
messages: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
messages: Secreted

9823:CCKAR
gene id: 9823:CCKAR
uniprot id: A0A4X1V8E5
uniprot id: I3LFK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9823:LPCAT3
gene id: 9823:LPCAT3
uniprot id: A0A481BA38
uniprot id: A0A8D1USY5
names: Subcellular Location Annotation
messages: Membrane

9823:PPP1R35
gene id: 9823:PPP1R35
uniprot id: A0A4X1UE31
uniprot id: F1RNM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP1R35 family.
messages: centriole

9823:TP23
gene id: 9823:TP23
uniprot id: Q95JC9
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acinar cells and secretory granules of the parotid gland.
messages: Secreted
messages: The parotid hormone stimulates dentinal fluid transport in teeth.

9823:IKBKB
gene id: 9823:IKBKB
uniprot id: A0A8D1BUX9
uniprot id: A5A757
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:SPCS3
gene id: 9823:SPCS3
uniprot id: A0A4X1VWP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:UGP2
gene id: 9823:UGP2
uniprot id: P79303
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Cytoplasm
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9823:NT5C3A
gene id: 9823:NT5C3A
uniprot id: A0A4X1SP24
uniprot id: A0A8D0TAA3
uniprot id: A0A8D1FDL2
uniprot id: A0A8D1J1G0
uniprot id: A0A8D1QYZ7
uniprot id: I3LCJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9823:LOC100158115
gene id: 9823:LOC100158115
uniprot id: A0A4X1TMZ1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9823:SNRPA
gene id: 9823:SNRPA
uniprot id: Q06AA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM U1 A/B'' family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity).
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component of a snRNP-free complex with SFPQ (By similarity).

9823:GYS2
gene id: 9823:GYS2
uniprot id: E0X6R4
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9823:TNFSF13
gene id: 9823:TNFSF13
uniprot id: A0A8D1ZAX8
uniprot id: A9Q6C0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:ADRA1B
gene id: 9823:ADRA1B
uniprot id: A0A4X1U0M4
uniprot id: F1RR36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

9823:NUBP1
gene id: 9823:NUBP1
uniprot id: A0A480QFS8
uniprot id: A0A5G2RCL1
uniprot id: A0A8D1A987
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9823:LOC100156741
gene id: 9823:LOC100156741
uniprot id: A0A286ZJQ0
uniprot id: A0A8D1E1K4
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:RPS6KB2
gene id: 9823:RPS6KB2
uniprot id: A0A8D0VH50
uniprot id: F1RUZ0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9823:HBB
gene id: 9823:HBB
uniprot id: P02067
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

9823:GINS4
gene id: 9823:GINS4
uniprot id: A0A480XGX2
uniprot id: A0A8D1EWA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9823:GPRASP1
gene id: 9823:GPRASP1
uniprot id: A0A8D1ALK9
uniprot id: F1RYE9
names: Similarity
messages: Belongs to the GPRASP family.

9823:LOC100519856
gene id: 9823:LOC100519856
uniprot id: A0A8D1XEP9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FIGN
gene id: 9823:FIGN
uniprot id: A0A480UT36
uniprot id: A0A8D1RRA4
names: Similarity
messages: Belongs to the AAA ATPase family.

9823:ACMSD
gene id: 9823:ACMSD
uniprot id: A0A4X1SS84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9823:CAV2
gene id: 9823:CAV2
uniprot id: Q2QLE2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
messages: Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).
messages: Nucleus
messages: Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).
messages: caveola

9823:RFC1
gene id: 9823:RFC1
uniprot id: A0A8D0YJM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

9823:ORAI2
gene id: 9823:ORAI2
uniprot id: A0A4X1UHY0
uniprot id: F1RKF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9823:TTL
gene id: 9823:TTL
uniprot id: P38160
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin--tyrosine ligase family.
messages: Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
messages: Monomer.

9823:FAM83F
gene id: 9823:FAM83F
uniprot id: A0A480E6T4
uniprot id: A0A8D1XPV8
names: Similarity
messages: Belongs to the FAM83 family.

9823:CCL11
gene id: 9823:CCL11
uniprot id: G8XRI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:ATP6V1E2
gene id: 9823:ATP6V1E2
uniprot id: A0A8D0U5A2
uniprot id: A0A8D1ECX5
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9823:IMPA1
gene id: 9823:IMPA1
uniprot id: O77591
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inositol monophosphatase superfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM.
messages: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.

9823:CD47
gene id: 9823:CD47
uniprot id: A8VKH9
uniprot id: Q9GKE8
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adhesive protein that mediates cell-to-cell interactions (PubMed:12153520). Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:12153520). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (By similarity). Plays a role in modulating pulmonary endothelin EDN1 signaling (By similarity). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (By similarity). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (By similarity). In response to THBS1, negatively modulates wound healing. Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction (By similarity). May prevent premature elimination of red blood cells (By similarity).
messages: Cell membrane
messages: Membrane
messages: Monomer (By similarity). Interacts with THBS1 (via the C-terminal domain) (By similarity) (PubMed:12153520). Interacts with SIRPA (By similarity). Interacts with FAS/CD95; interaction may be enhanced by functional activation (By similarity). Interacts with SIRPG, UBQLN1 and UBQLN2 (By similarity). May interact with fibrinogen (PubMed:12153520).
messages: Widely expressed, detected in kidney, liver, platelets, thymus, spleen, macrophages, bone marrow and peripheral blood mononuclear cells.

9823:NUDT5
gene id: 9823:NUDT5
uniprot id: A0A480XE17
uniprot id: A0A8D0Q0V6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9823:RIC8A
gene id: 9823:RIC8A
uniprot id: A0A480TRI9
uniprot id: A0A4X1VZI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9823:OBP2B
gene id: 9823:OBP2B
uniprot id: P53715
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket (By similarity).
messages: Predominantly monomer (By similarity). May form homodimer (By similarity). Interacts with LMBR1L; this interaction mediates the endocytosis of LCN1 (By similarity).
messages: Secreted

9823:CRABP1
gene id: 9823:CRABP1
uniprot id: A0A4X1USY8
uniprot id: B3F0B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9823:LEFTY2
gene id: 9823:LEFTY2
uniprot id: A0A8D1ERX8
uniprot id: D3K5M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9823:CDK1
gene id: 9823:CDK1
uniprot id: A0A8D1I9P1
uniprot id: C0SW08
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:PSMA6
gene id: 9823:PSMA6
uniprot id: B6VAQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus

9823:SEC23A
gene id: 9823:SEC23A
uniprot id: A0A4X1TF27
uniprot id: F1SHL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9823:ST6GALNAC4
gene id: 9823:ST6GALNAC4
uniprot id: Q704X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9823:PDE6H
gene id: 9823:PDE6H
uniprot id: A0A287AXH0
uniprot id: A0A8D1SBW4
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9823:SPIN1
gene id: 9823:SPIN1
uniprot id: D3K5M6
names: Similarity
messages: Belongs to the SPIN/STSY family.

9823:CCM2
gene id: 9823:CCM2
uniprot id: F1ST61
names: Similarity
messages: Belongs to the CCM2 family.

9823:PEX12
gene id: 9823:PEX12
uniprot id: A0A4X1T9A1
uniprot id: F1S181
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.
messages: Membrane
messages: Peroxisome membrane

9823:CCDC153
gene id: 9823:CCDC153
uniprot id: A0A480MPJ4
uniprot id: A0A4X1SF06
uniprot id: A0A4X1SFW9
names: Similarity
messages: Belongs to the UPF0610 family.

9823:CHL1
gene id: 9823:CHL1
uniprot id: A0A287ASJ8
uniprot id: A0A8D1A718
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9823:ZSCAN9
gene id: 9823:ZSCAN9
uniprot id: A0A4X1VF90
names: Subcellular Location Annotation
messages: Nucleus

9823:FTL
gene id: 9823:FTL
uniprot id: A0A8D1HA22
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9823:MITF
gene id: 9823:MITF
uniprot id: D2JUK3
uniprot id: Q4LE87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9823:TM9SF4
gene id: 9823:TM9SF4
uniprot id: A0A287BSC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9823:NRN1L
gene id: 9823:NRN1L
uniprot id: A0A8D0ZMW8
uniprot id: I3LQE2
names: Similarity
messages: Belongs to the neuritin family.

9823:SULT1E1
gene id: 9823:SULT1E1
uniprot id: Q95MF8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:TATDN3
gene id: 9823:TATDN3
uniprot id: A0A287A4L5
uniprot id: A0A4X1TIQ0
uniprot id: A0A4X1TN24
uniprot id: A0A8D1Y928
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9823:AP3M1
gene id: 9823:AP3M1
uniprot id: A0A287AM27
uniprot id: A0A4X1SRE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9823:LSM14A
gene id: 9823:LSM14A
uniprot id: A0A8D0P6Z5
uniprot id: R4JU57
names: Similarity
messages: Belongs to the LSM14 family.

9823:C2H19orf25
gene id: 9823:C2H19orf25
uniprot id: A0A4X1VTF6
uniprot id: A0A8D0JJC0
names: Similarity
messages: Belongs to the UPF0449 family.

9823:OVGP1
gene id: 9823:OVGP1
uniprot id: Q28990
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.
messages: Oviduct.
messages: secretory vesicle

9823:SERBP1
gene id: 9823:SERBP1
uniprot id: A0A4X1V0E9
uniprot id: A0A8D1RKR9
uniprot id: F1S827
names: Similarity
messages: Belongs to the SERBP1-HABP4 family.

9823:USP16
gene id: 9823:USP16
uniprot id: A0A286ZPB7
uniprot id: A0A480V986
uniprot id: A0A8D1G8U2
uniprot id: A0A8D1KP44
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9823:ADSL
gene id: 9823:ADSL
uniprot id: A0A4X1W0L6
uniprot id: B3VMQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

9823:PDRG1
gene id: 9823:PDRG1
uniprot id: A0A8D0XDX9
uniprot id: A0A8D1W6V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9823:MLST8
gene id: 9823:MLST8
uniprot id: A0A4X1VW75
uniprot id: A0A8D0QL72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9823:LOC100157002
gene id: 9823:LOC100157002
uniprot id: A0A4X1SNR2
uniprot id: A0A8D0YP29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9823:CS
gene id: 9823:CS
uniprot id: P00889
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Homodimer.
messages: Methylated (PubMed:7093227). Trimethylation at Lys-395 by CSKMT decreases citrate synthase activity (By similarity).
messages: Mitochondrion matrix

9823:KCNJ9
gene id: 9823:KCNJ9
uniprot id: A0A5G2R5J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9823:LOC100620620
gene id: 9823:LOC100620620
uniprot id: A0A287BIM6
uniprot id: A0A4X1T8J7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:EIF4G1
gene id: 9823:EIF4G1
uniprot id: A0A480IQ15
uniprot id: A0A480VXI3
uniprot id: A0A4X1UP28
uniprot id: A0A4X1URB6
uniprot id: A0A8D0QG87
uniprot id: A0A8D0S1T9
uniprot id: A0A8D0WUP9
uniprot id: F8TEL5
uniprot id: I3LMH4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9823:GLIPR1
gene id: 9823:GLIPR1
uniprot id: F1SGE0
names: Similarity
messages: Belongs to the CRISP family.

9823:SLC5A7
gene id: 9823:SLC5A7
uniprot id: A0A4X1W1N8
uniprot id: F1SU25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9823:NME5
gene id: 9823:NME5
uniprot id: A0A8D0HQU0
uniprot id: A0A8D0ZP73
uniprot id: I3LN92
names: Similarity
messages: Belongs to the NDK family.

9823:HOXA11
gene id: 9823:HOXA11
uniprot id: A0A8D0NE02
uniprot id: F1SHT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9823:SPTLC3
gene id: 9823:SPTLC3
uniprot id: A0A4X1UR31
uniprot id: F1SBJ7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9823:SATB1
gene id: 9823:SATB1
uniprot id: A0A4X1UMR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9823:STOML1
gene id: 9823:STOML1
uniprot id: A0A8D1I1I8
uniprot id: A0A8D1M8E1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9823:LOC100514828
gene id: 9823:LOC100514828
uniprot id: A0A8W4FKV2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LHFPL5
gene id: 9823:LHFPL5
uniprot id: A0A4X1SY33
uniprot id: F1RYX7
names: Subcellular Location Annotation
messages: Membrane

9823:SLC39A3
gene id: 9823:SLC39A3
uniprot id: A0A4X1VMY9
uniprot id: A0A8D1QY22
names: Subcellular Location Annotation
messages: Membrane

9823:MRPL16
gene id: 9823:MRPL16
uniprot id: A0A480MAF3
uniprot id: A0A8D1RWV1
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9823:ELP4
gene id: 9823:ELP4
uniprot id: A0A4X1SWT6
uniprot id: F1SGP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

9823:ACTL6A
gene id: 9823:ACTL6A
uniprot id: A0A4X1V4J6
uniprot id: F1SGC8
names: Similarity
messages: Belongs to the actin family.

9823:PPP3CB
gene id: 9823:PPP3CB
uniprot id: A0A8D1H101
uniprot id: A0A8D1XDF9
uniprot id: F1SU57
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9823:DPYSL2
gene id: 9823:DPYSL2
uniprot id: A0A4X1VC81
uniprot id: A0A8D0T416
uniprot id: A0A8D0VGN5
uniprot id: F1RJT3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9823:LYRM9
gene id: 9823:LYRM9
uniprot id: A0A4X1TR76
uniprot id: A0A8D0Y253
uniprot id: A0A8D1HR18
uniprot id: A0A8W4FJA3
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

9823:PHB2
gene id: 9823:PHB2
uniprot id: A0A4X1UWE0
uniprot id: A0A5G2QT83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9823:ALDH2
gene id: 9823:ALDH2
uniprot id: Q2XQV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.

9823:SLBP
gene id: 9823:SLBP
uniprot id: A0A4X1T2Q7
uniprot id: F1S9F2
names: Similarity
messages: Belongs to the SLBP family.

9823:ATG2B
gene id: 9823:ATG2B
uniprot id: A0A8D1SGN7
uniprot id: D7RA36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9823:NSUN5
gene id: 9823:NSUN5
uniprot id: A0A480RAA0
uniprot id: A0A8D1YNY7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9823:LOC100520009
gene id: 9823:LOC100520009
uniprot id: A0A4X1V337
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100526148
gene id: 9823:LOC100526148
uniprot id: A0A286ZXD6
uniprot id: A0A4X1VL59
names: Similarity
messages: Belongs to the SPIN/STSY family.

9823:RPS27A
gene id: 9823:RPS27A
uniprot id: A0A4X1WDC9
uniprot id: A0A8D0THD4
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

9823:PHEROC
gene id: 9823:PHEROC
uniprot id: A0A4X1VKP2
uniprot id: A0A8D1PM14
names: Subcellular Location Annotation
messages: Secreted

9823:ARPC2
gene id: 9823:ARPC2
uniprot id: A0A4X1UM70
uniprot id: F1SS01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9823:EFNA2
gene id: 9823:EFNA2
uniprot id: A0A4X1VP93
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:TMED3
gene id: 9823:TMED3
uniprot id: A0A8D0YZV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9823:HOXB5
gene id: 9823:HOXB5
uniprot id: A0A8D1K7X8
uniprot id: F1RWG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:TMEM186
gene id: 9823:TMEM186
uniprot id: A0A287AQT2
uniprot id: A0A8D0VIL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9823:KIF3A
gene id: 9823:KIF3A
uniprot id: A0A4X1UWV9
uniprot id: A0A4X1UXZ4
uniprot id: A0A4X1UY17
uniprot id: A0A5G2QP73
uniprot id: A0A8D1PQB3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:TWIST1
gene id: 9823:TWIST1
uniprot id: A0A4X1TEI0
uniprot id: A0A8W4FJQ2
names: Function
messages: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer.

9823:TNFRSF4
gene id: 9823:TNFRSF4
uniprot id: A0A287A7B3
uniprot id: A0A4X1W8N2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:APOOL
gene id: 9823:APOOL
uniprot id: A0A4X1W4W5
uniprot id: A0A5G2QPN0
uniprot id: A0A8D1RYM2
uniprot id: F1S1Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9823:PER1
gene id: 9823:PER1
uniprot id: A0A8D1RLF4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:NTAN1
gene id: 9823:NTAN1
uniprot id: Q28955
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer.
messages: N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position.

9823:SLC2A8
gene id: 9823:SLC2A8
uniprot id: A0A480HHY7
uniprot id: A0A4X1U9S2
uniprot id: A0A8D1HFS4
uniprot id: F1RS19
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9823:SRSF1
gene id: 9823:SRSF1
uniprot id: Q3YLA6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Asymmetrically dimethylated at arginines, probably by PRMT1, methylation promotes localization to nuclear speckles.
messages: Belongs to the splicing factor SR family.
messages: Consists of two polypeptides of p32 and p33. Identified in the spliceosome C complex. Component of a ribonucleoprotein complex containing mRNAs and RNA-binding proteins including DDX5, HNRNPH2 and SRSF1 as well as splicing regulator ARVCF. In vitro, self-associates and binds SRSF2, SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with SAFB/SAFB1. Interacts with PSIP1/LEDGF. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus). Interacts with SRPK1 and a sliding docking interaction is essential for its sequential and processive phosphorylation by SRPK1. Interacts with NXF1. Interacts with CCNL1, CCNL2 and CDK11B. Interacts with RRP1B. Interacts (when phosphorylated in its RS domain) with TNPO3; promoting nuclear import. Interacts with ILDR1 (via C-terminus) and ILDR2.
messages: Cytoplasm
messages: Nucleus speckle
messages: Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Phosphorylated by SRPK1 at multiple serines in its RS domain via a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds to a docking groove in the large lobe of the kinase domain of SRPK1 and this induces certain structural changes in SRPK1 and/or RRM 2 domain of SRSF1, allowing RRM 2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM 2, which then docks at the docking groove of SRPK1. This also signals RRM 2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed (By similarity).
messages: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway (By similarity).
messages: The RRM 2 domain plays an important role in governing both the binding mode and the phosphorylation mechanism of the RS domain by SRPK1. RS domain and RRM 2 are uniquely positioned to initiate a highly directional (C-terminus to N-terminus) phosphorylation reaction in which the RS domain slides through an extended electronegative channel separating the docking groove of SRPK1 and the active site. RRM 2 binds toward the periphery of the active site and guides the directional phosphorylation mechanism. Both the RS domain and an RRM domain are required for nucleocytoplasmic shuttling (By similarity).

9823:RPL6
gene id: 9823:RPL6
uniprot id: Q2YGT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL6 family.
messages: Component of the large ribosomal subunit (PubMed:24930395). May bind IPO9 with low affinity (By similarity).
messages: Component of the large ribosomal subunit (PubMed:24930395). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:24930395).
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9823:XKR9
gene id: 9823:XKR9
uniprot id: A0A8D1RUM0
uniprot id: F1RU13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9823:UIMC1
gene id: 9823:UIMC1
uniprot id: A0P8Z5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAP80 family.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1. Interacts with UBE2I. Interacts with NR6A1. Interacts with ESR1 (By similarity). Interacts with TSP57 (By similarity). Interacts with TRAIP (By similarity).
messages: Nucleus
messages: Phosphorylated upon DNA damage by ATM or ATR.
messages: Sumoylated.
messages: The Abraxas-interacting region (AIR) mediates the interaction with ABRAXAS1.
messages: The tandem UIM domains form a continuous 60 Angstrom-long alpha-helix and mediate binding to 'Lys-63'-linked ubiquitins. UIM1 and UIM2 bind to the proximal and distal ubiquitin moieties and recognize an 'Ile-44'-centered hydrophobic patch. Since UIMs don't interact with the 'Lys-63' isopeptide bond the UIM-linker region between the 2 UIM domains determines the selectivity for 'Lys-63'-linkage, and its length is very important for specificity.
messages: Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

9823:GPM6B
gene id: 9823:GPM6B
uniprot id: A0A4X1UQC2
uniprot id: A0A4X1UV67
uniprot id: A0A8D1UT30
uniprot id: A0A8D1Y7W3
uniprot id: F1SRH8
uniprot id: K7GLP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9823:ATL1
gene id: 9823:ATL1
uniprot id: A0A4X1SG47
uniprot id: A0A4X1SGI8
uniprot id: F1SHX5
uniprot id: F1SHX6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9823:PTGIS
gene id: 9823:PTGIS
uniprot id: A0A480J0J0
uniprot id: A0A8D0ZAZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
messages: Endoplasmic reticulum membrane

9823:TAF7L
gene id: 9823:TAF7L
uniprot id: A0A4X1W3R0
uniprot id: A0A5G2QH00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9823:LOC100514488
gene id: 9823:LOC100514488
uniprot id: A0A8W4FH17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RORC
gene id: 9823:RORC
uniprot id: A0A8D0Q7K3
uniprot id: A0A8D1A5G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9823:AK4
gene id: 9823:AK4
uniprot id: A0A4X1THS1
uniprot id: B1NI70
uniprot id: Q15B97
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

9823:TNNT3
gene id: 9823:TNNT3
uniprot id: Q75NG9
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9823:TTR
gene id: 9823:TTR
uniprot id: P50390
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transthyretin family.
messages: Detected in plasma and cerebrospinal fluid (at protein level). Highly expressed in the choroid plexus. Detected in liver.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation.
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9823:TYR
gene id: 9823:TYR
uniprot id: A0A8D1FZ43
uniprot id: Q4R1H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9823:NDUFB5
gene id: 9823:NDUFB5
uniprot id: A0A5G2R7U1
uniprot id: A0A8D0U647
uniprot id: F1SGC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:DAZL
gene id: 9823:DAZL
uniprot id: A0A1B2TT46
uniprot id: A0A8D0IUM1
names: Subcellular Location Annotation
messages: Cytoplasm

9823:CD9
gene id: 9823:CD9
uniprot id: Q8WMQ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (By similarity). Interacts with integrin ITGA6:ITGB1; interaction takes place in oocytes and is involved in sperm-egg fusion (By similarity). Part of integrin-tetraspanin complexes composed of CD81, beta-1 and beta-2 integrins in the membrane of monocyte/macrophages (By similarity). Interacts with CD63; identified in a complex with CD63 and ITGB3. Associates with CR2/CD21 and with PTGFRN/CD9P1. Part of a complex composed of CD9, CD81, PTGFRN and IGSF8 (By similarity). Interacts directly with IGSF8. Interacts with PDPN; this interaction is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Interacts (on T cell side) with CD81 at immunological synapses between antigen-presenting cells and T cells (By similarity).
messages: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity).
messages: Membrane
messages: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion.
messages: Ubiquitous.
messages: extracellular exosome

9823:FLT3
gene id: 9823:FLT3
uniprot id: A0A4X1TMR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Membrane

9823:RNF8
gene id: 9823:RNF8
uniprot id: A0A4X1SS01
uniprot id: A0A4X1SSS0
uniprot id: A0A4X1SST0
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9823:SPIN3
gene id: 9823:SPIN3
uniprot id: A0A480RFK2
uniprot id: A0A4X1VJK4
names: Similarity
messages: Belongs to the SPIN/STSY family.

9823:PLPPR1
gene id: 9823:PLPPR1
uniprot id: A0A480RSD9
uniprot id: A0A4X1VFS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9823:UQCR10
gene id: 9823:UQCR10
uniprot id: A0A8D1J3N6
uniprot id: Q2EN79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9823:LOC100523964
gene id: 9823:LOC100523964
uniprot id: A0A4X1W9L8
uniprot id: A0A8D0IP90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9823:CETN2
gene id: 9823:CETN2
uniprot id: A0A4X1TCT6
uniprot id: A0A8D1YFS9
names: Similarity
messages: Belongs to the centrin family.

9823:UBE2E2
gene id: 9823:UBE2E2
uniprot id: Q06AB0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:EXOC3L1
gene id: 9823:EXOC3L1
uniprot id: A0A4X1UM37
uniprot id: F1RFW4
names: Similarity
messages: Belongs to the SEC6 family.

9823:LOC100621352
gene id: 9823:LOC100621352
uniprot id: A0A8D0PL42
uniprot id: I3L7J3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:LAMP2
gene id: 9823:LAMP2
uniprot id: A0A287B836
uniprot id: A0A4X1W6B1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9823:ST6GALNAC5
gene id: 9823:ST6GALNAC5
uniprot id: Q704S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9823:FADS2
gene id: 9823:FADS2
uniprot id: D2D0E4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9823:TNP1
gene id: 9823:TNP1
uniprot id: P17306
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear transition protein 1 family.
messages: Chromosome
messages: Nucleus
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: Testis.

9823:STX6
gene id: 9823:STX6
uniprot id: A0A4X1U1S9
uniprot id: A0A8D1RYP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9823:IFI30
gene id: 9823:IFI30
uniprot id: B3SP85
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GILT family.
messages: Both precursor form and mature form have thiol reductase activity.
messages: By LPS in spleen and blood.
messages: Dimer; disulfide-linked.
messages: Expressed in many tissues, including spleen, liver, lung, heart, intestine, blood and kidney.
messages: Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).
messages: Lysosome
messages: N-glycosylated. Sugar chains contain mannose-6-phosphate (By similarity).
messages: Secreted
messages: Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases (By similarity).

9823:RRAGA
gene id: 9823:RRAGA
uniprot id: A0A4X1WBE4
uniprot id: F2Z5Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9823:TFRC
gene id: 9823:TFRC
uniprot id: Q8HZV3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
messages: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Interacts with SH3BP4 (By similarity). Interacts with SH3BP3. Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (By similarity).
messages: Melanosome
messages: Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation (By similarity). Stearoylation does not affect iron uptake (By similarity).

9823:NPRL2
gene id: 9823:NPRL2
uniprot id: A0A286ZXP1
uniprot id: A0A8D1G8F6
uniprot id: A0A8D1PRD1
names: Similarity
messages: Belongs to the NPR2 family.

9823:LGR4
gene id: 9823:LGR4
uniprot id: A0A4X1SXY8
uniprot id: F1SGM5
names: Subcellular Location Annotation
messages: Membrane

9823:NME6
gene id: 9823:NME6
uniprot id: A0A8D1RAL0
uniprot id: F1SKM8
names: Similarity
messages: Belongs to the NDK family.

9823:ONECUT1
gene id: 9823:ONECUT1
uniprot id: A0A480JMP2
uniprot id: A0A8D1E675
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9823:ERO1A
gene id: 9823:ERO1A
uniprot id: B6CVD7
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane
messages: Enzyme activity is tightly regulated to prevent the accumulation of reactive oxygen species in the endoplasmic reticulum. Reversibly down-regulated by the formation of disulfide bonds between the active site Cys-94 and Cys-131, and between Cys-99 and Cys-104. Glutathione may be required to regulate its activity in the endoplasmic reticulum (By similarity).
messages: Golgi apparatus lumen
messages: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.
messages: Phosphorylated on Ser-145 by FAM20C in the Golgi which increases its enzymatic activity (By similarity). Phosphorylation is induced by lactation (By similarity). It is also induced by hypoxia and reductive stress (By similarity).
messages: Predominantly monomer. May function both as a monomer and a homodimer. Interacts with PDILT. Interacts with ERP44; the interaction results in retention of ERO1A in the endoplasmic reticulum.
messages: Secreted
messages: The Cys-94/Cys-99 and Cys-394/Cys-397 disulfide bonds constitute the redox-active center. The Cys-94/Cys-99 disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys-394/Cys-397. The regulatory Cys-99/Cys-104 disulfide bond stabilizes the other regulatory bond Cys-94/Cys-131 (By similarity).
messages: dendrite

9823:CCDC90B
gene id: 9823:CCDC90B
uniprot id: A0A8D1I261
uniprot id: F1STU7
names: Similarity
messages: Belongs to the CCDC90 family.

9823:ELAVL1
gene id: 9823:ELAVL1
uniprot id: A0A8D1MVT4
uniprot id: D3K5N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm

9823:WNK3
gene id: 9823:WNK3
uniprot id: A0A480ESI3
uniprot id: A0A8D1CV61
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9823:ST7L
gene id: 9823:ST7L
uniprot id: A0A286ZJZ2
uniprot id: A0A4X1T8Y2
uniprot id: A0A4X1T9M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9823:ADA2
gene id: 9823:ADA2
uniprot id: P58780
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity).
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Binds 1 zinc ion per subunit.
messages: High-affinity binding to heparin/glycosaminoclycan (GAG) is mediated by a large, highly positively charged surface at the interface of dimer's subunits involving approximately residues 25-40, 386-393, and 419-425.
messages: Homodimer. Interacts with adenosine receptors. Binds heparin (By similarity).
messages: Secreted
messages: The PRB domain is involved in receptor binding, and may be responsible for the cytokine-like growth factor activity due to it's sharing of several structural properties with chemokines.

9823:STARD3NL
gene id: 9823:STARD3NL
uniprot id: A0A8D1WQK6
uniprot id: E7EAU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Membrane

9823:LAMA3
gene id: 9823:LAMA3
uniprot id: A0A480RXN2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9823:AKAP10
gene id: 9823:AKAP10
uniprot id: P57770
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).
messages: Membrane
messages: Mitochondrion
messages: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

9823:GALNTL5
gene id: 9823:GALNTL5
uniprot id: A0A4X1UI21
uniprot id: F1SSN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Membrane

9823:LGI1
gene id: 9823:LGI1
uniprot id: A0A8D0X5U1
uniprot id: A0A8D1GFJ2
names: Subcellular Location Annotation
messages: Secreted

9823:RPL18A
gene id: 9823:RPL18A
uniprot id: A0A8D0TRE3
uniprot id: A0A8D1UYD5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9823:ISG15
gene id: 9823:ISG15
uniprot id: A0A287AB58
uniprot id: A0A8D1LSM4
names: Subcellular Location Annotation
messages: cytosol

9823:PTHLH
gene id: 9823:PTHLH
uniprot id: A0A4X1V7L2
uniprot id: Q866H2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

9823:NR5A2
gene id: 9823:NR5A2
uniprot id: H9DUR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9823:RPL35A
gene id: 9823:RPL35A
uniprot id: A0A4X1TPT1
uniprot id: A0A8D0RXZ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9823:AVP
gene id: 9823:AVP
uniprot id: P01183
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A shorter neurophysin molecule (32-123) is called neurophysin-I and is derived from the complete protein (called neurophysin III) by proteolytic degradation (in vivo or after extraction).
messages: Belongs to the vasopressin/oxytocin family.
messages: Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (By similarity). Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (By similarity).
messages: Neurophysin 2 specifically binds vasopressin.
messages: Secreted
messages: Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (By similarity).

9823:ACADL
gene id: 9823:ACADL
uniprot id: A0A480PCQ6
uniprot id: P79274
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3.
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (By similarity).
messages: Mitochondrion matrix

9823:RBP1
gene id: 9823:RBP1
uniprot id: A0A8D1YU42
uniprot id: F1SL52
uniprot id: Q53J08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9823:POU2F1
gene id: 9823:POU2F1
uniprot id: A0A287BKD1
uniprot id: A0A4X1VDX5
uniprot id: A0A8D0RPU8
uniprot id: A0A8D1H765
uniprot id: A0A8D1XNZ0
uniprot id: F1S265
uniprot id: Q29076
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Interacts with POU2AF1; the interaction increases POU2F1 transactivation activity. Interacts with NR3C1, AR, PGR and HCFC1.
messages: Nucleus
messages: Phosphorylated by PRKDC.
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9823:LOC100522842
gene id: 9823:LOC100522842
uniprot id: A0A8W4FBV5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9823:AQN-1
gene id: 9823:AQN-1
uniprot id: A0A4X1SHD7
uniprot id: Q4R0H3
names: Caution
names: Similarity
messages: Belongs to the spermadhesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100511184
gene id: 9823:LOC100511184
uniprot id: A0A4X1V1Z1
uniprot id: F1S9Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RC3H1
gene id: 9823:RC3H1
uniprot id: A0A8D1KX72
uniprot id: A0A8D1QIX7
names: Subcellular Location Annotation
messages: P-body

9823:NOX4
gene id: 9823:NOX4
uniprot id: A0A4X1TZY9
uniprot id: A0A4X1U272
uniprot id: A0A5G2QTR4
uniprot id: A0A8D0LV61
uniprot id: A0A8D0V5M6
uniprot id: K7GRK1
names: Subcellular Location Annotation
messages: Membrane

9823:SLC5A3
gene id: 9823:SLC5A3
uniprot id: A0A287A6C9
uniprot id: A0A8D1DZU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9823:RPL9
gene id: 9823:RPL9
uniprot id: A0A4X1V3Z6
uniprot id: I3LP78
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

9823:LOC100520723
gene id: 9823:LOC100520723
uniprot id: A0A5G2R7L8
uniprot id: A0A8D1XVD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NKIRAS1
gene id: 9823:NKIRAS1
uniprot id: A0A8D0R1X0
uniprot id: I3L911
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9823:PTN
gene id: 9823:PTN
uniprot id: A0A480VM92
uniprot id: A0A8D0UHY1
uniprot id: P79281
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pleiotrophin family.
messages: Interacts with ALK and NEK6. Interacts with PTPRZ1 (via chondroitin sulfate groups); promotes formation of homooligomers; oligomerization impairs tyrosine phosphatase activity. Forms a complex with PTPRZ1 and CTNNB1; this complex inactivates PTPRZ1 protein tyrosine phosphatase activity through PTN interaction and stimulates tyrosine phosphorylation of CTNNB1. Interacts with ITGB3 and ITGA5. Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through ITGB3 'Tyr-773' phosphorylation (By similarity). Interacts with SDC3 (via heparan sulfate chains); this interaction mediates the neurite outgrowth-promoting signal from PTN to the cytoskeleton of growing neurites; this interaction mediates osteoblast recruitment. Interacts with GPC2 (via heparan sulfate); this interaction promotes neurite outgrowth through binding of PTN with chondroitin sulfate of proteoglycans, thereby releasing PTPRS of chondroitin sulfate proteoglycans (CSPGs) and leading to binding with heparan sulfate of GPC2 (By similarity).
messages: Phosphorylated by NEK6.
messages: Secreted
messages: Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway. Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway. Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion. Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-…

9823:RBP2
gene id: 9823:RBP2
uniprot id: P50121
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: Intracellular transport of retinol.

9823:SLC15A3
gene id: 9823:SLC15A3
uniprot id: A0A480MV35
uniprot id: A0A4X1VPF2
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

9823:CERS2
gene id: 9823:CERS2
uniprot id: A0A287A843
uniprot id: A0A8D0MHP1
uniprot id: A0A8D0SKI3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9823:C4A
gene id: 9823:C4A
uniprot id: B0LFE9
names: Subcellular Location Annotation
messages: Secreted

9823:RNF10
gene id: 9823:RNF10
uniprot id: A0A8D0PIS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

9823:KRT84
gene id: 9823:KRT84
uniprot id: A0A4X1WD65
names: Similarity
messages: Belongs to the intermediate filament family.

9823:MSMO1
gene id: 9823:MSMO1
uniprot id: Q6UGB2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol.
messages: Endoplasmic reticulum membrane
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

9823:SRPX
gene id: 9823:SRPX
uniprot id: A0A4X1U3P4
uniprot id: A0A4X1U8J2
uniprot id: F1RXR1
uniprot id: K7GKF8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100510915
gene id: 9823:LOC100510915
uniprot id: A0A4X1UZX8
uniprot id: A0A8D0W364
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RFC4
gene id: 9823:RFC4
uniprot id: A0A4X1UGI7
uniprot id: F1SFI3
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9823:MSX1
gene id: 9823:MSX1
uniprot id: C4TJC7
names: Subcellular Location Annotation
messages: Nucleus

9823:SUMF1
gene id: 9823:SUMF1
uniprot id: A0A480WFL8
uniprot id: A0A8D0ZT85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9823:GTPBP4
gene id: 9823:GTPBP4
uniprot id: A0A4X1T044
uniprot id: I3LJI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9823:MTF2
gene id: 9823:MTF2
uniprot id: A0A4X1U2W1
uniprot id: A0A8D0NU79
uniprot id: F1S531
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9823:OTX1
gene id: 9823:OTX1
uniprot id: A0A287ARL1
uniprot id: A0A4X1WBI3
names: Subcellular Location Annotation
messages: Nucleus

9823:HBM
gene id: 9823:HBM
uniprot id: A0A4X1UM07
uniprot id: F1RGX5
names: Similarity
messages: Belongs to the globin family.

9823:POMGNT1
gene id: 9823:POMGNT1
uniprot id: A0A287AMB9
uniprot id: A0A4X1WAD9
uniprot id: A0A8D0W5S0
uniprot id: F1S3V2
uniprot id: Q0KKC1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9823:RIMKLB
gene id: 9823:RIMKLB
uniprot id: A0A4X1U2S6
uniprot id: A0A8D0M4L4
names: Similarity
messages: Belongs to the RimK family.

9823:TAS2R38
gene id: 9823:TAS2R38
uniprot id: A0A8D0ZY27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9823:UPK2
gene id: 9823:UPK2
uniprot id: Q95L04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the uroplakin-2 family.
messages: Cell membrane
messages: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).
messages: Expressed only in the urothelium. Localizes to urothelial superficial cells.
messages: Interacts with uroplakin-1a (UPK1A).

9823:PPP2R1A
gene id: 9823:PPP2R1A
uniprot id: P54612
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase 2A regulatory subunit A family.
messages: Cytoplasm
messages: Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
messages: Lateral cell membrane
messages: Nucleus
messages: PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with FOXO1; the interaction dephosphorylates FOXO1 on AKT-mediated phosphorylation sites. Interacts with IPO9. Interacts with TP53 and SGO1. Interacts with PLA2G16; this interaction might decrease PP2A activity. Interacts with CTTNBP2NL. Interacts with GNA12; the interaction promotes protein phosphatase 2A activation causing dephosphorylation of MAPT. Interacts with CIP2A; this interaction stabilizes CIP2A (By similarity). Interacts with PABIR1/FAM122A (By similarity). Interacts with ADCY8; antagonizes interaction between ADCY8 and calmodulin (By similarity). Interacts with CRTC3 (when phosphorylated at 'Ser-391') (By similarity). Interacts with SPRY2 (By similarity).
messages: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (By similarity). Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity).
messages: centromere
messages: dendrite

9823:IL12RB2
gene id: 9823:IL12RB2
uniprot id: A0A8D0UJX9
uniprot id: Q8MJS1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain (By similarity).
messages: Membrane
messages: On IL12 stimulation, phosphorylated on C-terminal tyrosine residues.
messages: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway.
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.

9823:ADPRHL2
gene id: 9823:ADPRHL2
uniprot id: A0A480MAC3
uniprot id: A0A4X1VXS6
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9823:FGF6
gene id: 9823:FGF6
uniprot id: A0A287AFX3
uniprot id: A0A4X1UR46
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:LBP
gene id: 9823:LBP
uniprot id: B3F714
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

9823:GRK4
gene id: 9823:GRK4
uniprot id: A0A8D1PZE3
uniprot id: F1S8P7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9823:TMSB4X
gene id: 9823:TMSB4X
uniprot id: B3XXC3
uniprot id: Q95274
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AcSDKP is inactivated by ACE, which removes the dipeptide Lys-Pro from its C-terminus.
messages: Belongs to the thymosin beta family.
messages: Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity). Interacts with SERPINB1 (By similarity).
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: Potent inhibitor of bone marrow derived stem cell differentiation (By similarity). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity).
messages: cytoskeleton

9823:GGH
gene id: 9823:GGH
uniprot id: A0A286ZMB2
uniprot id: A0A4X1V297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9823:SEPT3
gene id: 9823:SEPT3
uniprot id: A0A173G6G5
uniprot id: A0A8D0MSK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9823:SLA-5
gene id: 9823:SLA-5
uniprot id: Q9TSW6
names: Similarity
messages: Belongs to the MHC class I family.

9823:ARF2
gene id: 9823:ARF2
uniprot id: B9V4E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9823:TTC4
gene id: 9823:TTC4
uniprot id: A0A8D1RVU2
names: Similarity
messages: Belongs to the TTC4 family.

9823:SMIM18
gene id: 9823:SMIM18
uniprot id: A0A4X1VV20
uniprot id: A0A8D0S5Y2
names: Subcellular Location Annotation
messages: Membrane

9823:TFE3
gene id: 9823:TFE3
uniprot id: A0A4X1T5N9
uniprot id: F1RW57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9823:FGFR1OP
gene id: 9823:FGFR1OP
uniprot id: A0A480K4F7
uniprot id: A0A8D0NMT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9823:WNK4
gene id: 9823:WNK4
uniprot id: A0A481B8A0
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9823:RBM3
gene id: 9823:RBM3
uniprot id: A0A480JVS5
uniprot id: A0A4X1VF00
uniprot id: A0A8D0M5N2
uniprot id: A0A8D1B194
names: Subcellular Location Annotation
messages: Cytoplasm

9823:BCLAF1
gene id: 9823:BCLAF1
uniprot id: A0A286ZMT9
uniprot id: A0A4X1VK93
uniprot id: A0A4X1VL28
uniprot id: A0A8D0XBI1
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9823:CDC25B
gene id: 9823:CDC25B
uniprot id: A0A287B203
uniprot id: A0A8D1NVI3
uniprot id: A0A8D1R4F1
uniprot id: D2KX74
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9823:CACNG6
gene id: 9823:CACNG6
uniprot id: A0A8D1T738
uniprot id: F1RNI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

9823:GMPPB
gene id: 9823:GMPPB
uniprot id: A0A4X1SQL6
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9823:HPS5
gene id: 9823:HPS5
uniprot id: A5A774
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

9823:MRPL33
gene id: 9823:MRPL33
uniprot id: A0A4X1TLP9
uniprot id: A0A8D1FGP6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9823:RDH12
gene id: 9823:RDH12
uniprot id: A0A8D0RCK9
uniprot id: F1SA23
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:PTGDR2
gene id: 9823:PTGDR2
uniprot id: A0A4X1VND5
uniprot id: K7GSF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

9823:SERPINA1
gene id: 9823:SERPINA1
uniprot id: P50447
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin (By similarity).
messages: Interacts with CELA2A (By similarity). Interacts with ERGIC3 and LMAN1/ERGIC53 (By similarity). Interacts with PRSS1/Trypsin (By similarity).
messages: Secreted
messages: The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).

9823:LOC100518052
gene id: 9823:LOC100518052
uniprot id: A0A4X1SJX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ARID3A
gene id: 9823:ARID3A
uniprot id: A0A8D1KHX7
uniprot id: F1S6T2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Transcription factor.

9823:GRK5
gene id: 9823:GRK5
uniprot id: A0A4X1SV29
uniprot id: F1S417
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9823:APOD
gene id: 9823:APOD
uniprot id: A0A8D0PJF8
uniprot id: F1SQX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Homodimer.
messages: Secreted

9823:TUBB4A
gene id: 9823:TUBB4A
uniprot id: A0A480UV25
uniprot id: A0A8D1HA58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9823:SREBF1
gene id: 9823:SREBF1
uniprot id: O97676
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activation by cleavage is down-regulated upon activation of SIRT3-dependent PRKAA1/AMPK-alpha signaling cascade which leads to inhibition of ATP-consuming lipogenesis to restore cellular energy balance.
messages: Belongs to the SREBP family.
messages: COPII-coated vesicle membrane
messages: Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein (By similarity). Interacts with CEBPA, the interaction produces a transcriptional synergy. Interacts with LMNA (By similarity).
messages: Endoplasmic reticulum membrane
messages: Forms a tight complex with SCAP, the SCAP-SREBP complex, in the endoplasmic reticulum membrane.
messages: Golgi apparatus membrane
messages: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation.
messages: Nucleus
messages: Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-403 by SIK1 represses activity possibly by inhibiting DNA-binding.
messages: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (By similarity). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity).
messages: Processed in the Golgi apparatus, releasing the protein from the membrane. At low cholesterol the SCAP-SREBP complex is recruited into COPII vesicles for export from the endoplasmic reticulum. In the Golgi, complex SREBPs are cleaved sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain, releasing the transcription factor from the Golgi membrane.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Ubiquitinated; the nuclear form has a rapid turnover and is rapidly ubiquitinated and degraded by the proteasome in the nucleus.

9823:LOC100517544
gene id: 9823:LOC100517544
uniprot id: A0A287A9V8
uniprot id: A0A8D0PK86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GABRP
gene id: 9823:GABRP
uniprot id: A0A8D0JAU8
uniprot id: F1RRX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:NDUFS8
gene id: 9823:NDUFS8
uniprot id: A0A286ZUN9
uniprot id: A0A287BDC0
uniprot id: A0A4X1SVK9
uniprot id: A0A8D2C1R2
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

9823:PEX14
gene id: 9823:PEX14
uniprot id: F1RHS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
messages: Peroxisome membrane

9823:MSI1
gene id: 9823:MSI1
uniprot id: I7GVS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Musashi family.
messages: Cytoplasm

9823:MYH2
gene id: 9823:MYH2
uniprot id: Q9TV63
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction. Required for cytoskeleton organization (By similarity).
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with GCSAM.
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-2 (MYO2).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9823:CCDC58
gene id: 9823:CCDC58
uniprot id: A0A8D1HB26
uniprot id: I3LE14
names: Similarity
messages: Belongs to the MIX23 family.

9823:LOC100154892
gene id: 9823:LOC100154892
uniprot id: A0A286ZHX1
uniprot id: A0A4X1V031
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9823:BAIAP2
gene id: 9823:BAIAP2
uniprot id: A0A480P5D4
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

9823:TPP1
gene id: 9823:TPP1
uniprot id: A0A8D1R6C0
uniprot id: I3L812
names: Cofactor
messages: Binds 1 Ca(2+) ion per subunit.

9823:STXBP5
gene id: 9823:STXBP5
uniprot id: A0A4X1VQV1
uniprot id: A0A4X1VSR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9823:LOC100624683
gene id: 9823:LOC100624683
uniprot id: A0A4X1U132
uniprot id: A0A8D0JLD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:AP1M1
gene id: 9823:AP1M1
uniprot id: A0A4X1UZG6
uniprot id: A0A4X1V0U3
uniprot id: A0A8D0ZTM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9823:PIGV
gene id: 9823:PIGV
uniprot id: A0A8D1ASY6
uniprot id: F1STS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9823:PTGES3
gene id: 9823:PTGES3
uniprot id: A0A8D1GTB2
uniprot id: A0A8D1UEM7
uniprot id: A0A8D1YC89
uniprot id: F1SL99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

9823:EIF4E
gene id: 9823:EIF4E
uniprot id: A0A4X1UC72
uniprot id: A0A8D0PVK2
uniprot id: A0A8D0Z5C8
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9823:LOC100515886
gene id: 9823:LOC100515886
uniprot id: A0A5G2R2J2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GK
gene id: 9823:GK
uniprot id: A0A4X1VFA8
uniprot id: A0A8D1B697
uniprot id: A0A8D1IXK3
uniprot id: B8XSK5
uniprot id: K7GRB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9823:LOC106509346
gene id: 9823:LOC106509346
uniprot id: A0A5G2QUK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NPY2R
gene id: 9823:NPY2R
uniprot id: A0A8D1F3D0
uniprot id: F1RYR8
uniprot id: O02836
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY.

9823:AIDA
gene id: 9823:AIDA
uniprot id: A0A4X1TLZ0
uniprot id: F1S9H0
names: Similarity
messages: Belongs to the AIDA family.

9823:PRPS1L1
gene id: 9823:PRPS1L1
uniprot id: A0A8D0TUK6
uniprot id: A0A8D0Y8E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9823:EGR1
gene id: 9823:EGR1
uniprot id: A0A8D0LED0
uniprot id: A0A8D0NAP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9823:HMGCS2
gene id: 9823:HMGCS2
uniprot id: O02734
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
messages: Homodimer.
messages: Mitochondrion
messages: Succinylated. Desuccinylated by SIRT5. Succinylation, at least at Lys-310, inhibits the enzymatic activity.

9823:B3GAT2
gene id: 9823:B3GAT2
uniprot id: A0A8D1YBK7
uniprot id: I3LR31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:IFITM1
gene id: 9823:IFITM1
uniprot id: A9QW81
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:DDX4
gene id: 9823:DDX4
uniprot id: A0A4X1SLB0
uniprot id: A0A5K1UMM8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9823:STRIP1
gene id: 9823:STRIP1
uniprot id: A0A4X1TD37
uniprot id: F1S614
names: Similarity
messages: Belongs to the STRIP family.

9823:CDH19
gene id: 9823:CDH19
uniprot id: A0A4X1TW58
uniprot id: F1SMY0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9823:CHRNB2
gene id: 9823:CHRNB2
uniprot id: A0A287BFD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:DCLRE1A
gene id: 9823:DCLRE1A
uniprot id: A0A480L7R0
uniprot id: A0A8D0R7I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9823:LDHB
gene id: 9823:LDHB
uniprot id: A0A8D1PFP5
uniprot id: F1SR05
uniprot id: P00336
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer (PubMed:7338899). Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria (By similarity).
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
messages: Mitochondrion inner membrane

9823:ALDH5A1
gene id: 9823:ALDH5A1
uniprot id: A0A481AID6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

9823:TMEM116
gene id: 9823:TMEM116
uniprot id: A0A287BB11
uniprot id: A0A4X1T9A0
uniprot id: A0A4X1TBM7
uniprot id: A0A8D0LZZ0
uniprot id: F1RJK9
names: Subcellular Location Annotation
messages: Membrane

9823:TLL2
gene id: 9823:TLL2
uniprot id: A0A287AKC2
uniprot id: A0A4X1UGP7
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:E2F8
gene id: 9823:E2F8
uniprot id: A0A287AUT3
uniprot id: A0A8D1Y9P1
uniprot id: A0A8D2C563
uniprot id: F1SFY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9823:TMEM115
gene id: 9823:TMEM115
uniprot id: A0A480E453
uniprot id: A0A4X1SJQ8
names: Subcellular Location Annotation
messages: Membrane

9823:ASF1A
gene id: 9823:ASF1A
uniprot id: A0A4X1TG55
uniprot id: F1SF37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9823:ARL6IP4
gene id: 9823:ARL6IP4
uniprot id: A0A287AL31
uniprot id: A0A4X1UG70
uniprot id: A0A4X1UHF9
uniprot id: A0A8D1KAM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: Nucleus speckle
messages: nucleolus

9823:GABRR1
gene id: 9823:GABRR1
uniprot id: A0A4X1VEA9
uniprot id: A0A8D2BLW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:TMEM230
gene id: 9823:TMEM230
uniprot id: A0A4X1UC59
uniprot id: A0A4X1UG78
uniprot id: A0A4X1UH58
uniprot id: A0A8D1C7Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9823:C1D
gene id: 9823:C1D
uniprot id: A0A4X1WBP4
uniprot id: A0A8D1UMH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9823:CNOT8
gene id: 9823:CNOT8
uniprot id: A0A8D1EPD3
uniprot id: F2Z590
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9823:NIT2
gene id: 9823:NIT2
uniprot id: A0A8D1CV10
uniprot id: F1SKY2
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9823:MMP13
gene id: 9823:MMP13
uniprot id: A0A481A6Z6
uniprot id: A0A8D1XG17
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9823:LY75
gene id: 9823:LY75
uniprot id: D6MT50
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ATP6V1G3
gene id: 9823:ATP6V1G3
uniprot id: A0A8D0ZRR7
uniprot id: A0A8D1ERN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9823:HSD17B10
gene id: 9823:HSD17B10
uniprot id: A0A8D0QWP1
uniprot id: K7GP28
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:PDCL
gene id: 9823:PDCL
uniprot id: A0A286ZXX5
uniprot id: A0A8D0P5W5
names: Similarity
messages: Belongs to the phosducin family.

9823:TMEM225B
gene id: 9823:TMEM225B
uniprot id: A0A8D0Q6D7
names: Subcellular Location Annotation
messages: Membrane

9823:KCNAB3
gene id: 9823:KCNAB3
uniprot id: A0A287BA57
uniprot id: A0A8D0JV74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

9823:CDC123
gene id: 9823:CDC123
uniprot id: A0A8D1KJH2
uniprot id: A0A8D2ADH9
uniprot id: F1RUP8
uniprot id: I3LND7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9823:RPN2
gene id: 9823:RPN2
uniprot id: Q9GL01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (By similarity). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with DDI2 (By similarity). Interacts with TMEM35A/NACHO (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9823:SFTPD
gene id: 9823:SFTPD
uniprot id: A0A287BPZ1
uniprot id: A0A8D0RCN8
uniprot id: Q9N1X4
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFTPD family.
messages: Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties (By similarity).
messages: Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
messages: Oligomeric complex of 4 set of homotrimers.
messages: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
messages: S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.
messages: extracellular matrix
messages: surface film

9823:TMEFF1
gene id: 9823:TMEFF1
uniprot id: A0A287BBI1
uniprot id: A0A4X1VEZ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:HTR6
gene id: 9823:HTR6
uniprot id: A0A4X1W6S7
uniprot id: A0A8D0IMH7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:SH2D1A
gene id: 9823:SH2D1A
uniprot id: Q06AA1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (By similarity).
messages: Interacts with CD84, CD244, LY9, SLAMF1 and FYN. Interacts with NTRK1, NTRK2 and NTRK3 (By similarity).

9823:WNT16
gene id: 9823:WNT16
uniprot id: A0A8D0PVA1
uniprot id: F1SJF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:CNDP2
gene id: 9823:CNDP2
uniprot id: A0A8D2A423
uniprot id: F1SNL7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9823:LOC100152489
gene id: 9823:LOC100152489
uniprot id: A0A287A6J1
uniprot id: A0A4X1VEA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:VEZT
gene id: 9823:VEZT
uniprot id: A0A480VKQ5
uniprot id: A0A4X1SH23
uniprot id: A0A8D1G8R2
uniprot id: F1SQP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9823:PPIF
gene id: 9823:PPIF
uniprot id: A0A287AP21
uniprot id: A0A4X1SIE5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9823:FBL
gene id: 9823:FBL
uniprot id: A0A8D0RWQ5
uniprot id: I3L5T3
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9823:MRPL44
gene id: 9823:MRPL44
uniprot id: A0A8D0MQC7
uniprot id: F1SR64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

9823:TMEM47
gene id: 9823:TMEM47
uniprot id: A0A4X1VH18
uniprot id: F2Z5B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9823:LTBR
gene id: 9823:LTBR
uniprot id: A0A8D1KZM8
uniprot id: K4J7V4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:TIGD3
gene id: 9823:TIGD3
uniprot id: A0A8D0TGD9
uniprot id: F1RRI0
names: Subcellular Location Annotation
messages: Nucleus

9823:FAM114A2
gene id: 9823:FAM114A2
uniprot id: A0A8D2A6M2
names: Similarity
messages: Belongs to the FAM114 family.

9823:MED27
gene id: 9823:MED27
uniprot id: Q6Q7J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
messages: Nucleus

9823:LOC100738816
gene id: 9823:LOC100738816
uniprot id: A0A8D1KKB3
uniprot id: A0A8W4FC01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MNAT1
gene id: 9823:MNAT1
uniprot id: A0A4X1WCT0
uniprot id: C9K507
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9823:REEP5
gene id: 9823:REEP5
uniprot id: A0A8D1SAX9
uniprot id: F1RLG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9823:SGCD
gene id: 9823:SGCD
uniprot id: A0A4X1TUU5
uniprot id: A0A8D1LZF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9823:RPL30
gene id: 9823:RPL30
uniprot id: A0A4X1TXJ8
uniprot id: A0A8D1IQG6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9823:FAM174B
gene id: 9823:FAM174B
uniprot id: A0A4X1UCT1
uniprot id: A0A8D1XSW2
uniprot id: F1SA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9823:SEC31B
gene id: 9823:SEC31B
uniprot id: A0A8D1HFE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

9823:SNCG
gene id: 9823:SNCG
uniprot id: A0A8D0RCE0
uniprot id: A7YX24
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.
messages: spindle

9823:LOC100519511
gene id: 9823:LOC100519511
uniprot id: A0A8D1K596
names: Similarity
messages: Belongs to the CFAP97 family.

9823:TRMT11
gene id: 9823:TRMT11
uniprot id: A0A481AJX3
uniprot id: A0A8D0MCI6
uniprot id: A0A8D0YGK1
uniprot id: A0A8D1GUW1
uniprot id: A0A8D1XSA1
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

9823:SIRT3
gene id: 9823:SIRT3
uniprot id: A0A8D0SIL8
uniprot id: A0A8D1P6H0
uniprot id: A8CYZ2
uniprot id: B7U9B0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

9823:GSKIP
gene id: 9823:GSKIP
uniprot id: A0A481B832
uniprot id: A0A8D0NQ94
names: Similarity
messages: Belongs to the GSKIP family.

9823:MMP3
gene id: 9823:MMP3
uniprot id: C9VZX5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9823:PPA1
gene id: 9823:PPA1
uniprot id: A0A4X1TE56
uniprot id: A0A5G2QKC9
names: Similarity
messages: Belongs to the PPase family.

9823:ICAM1
gene id: 9823:ICAM1
uniprot id: A0A8D1VF75
uniprot id: Q9MZU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9823:BCDIN3D
gene id: 9823:BCDIN3D
uniprot id: A0A287A7U6
uniprot id: A0A8D0QB17
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9823:LOC106510297
gene id: 9823:LOC106510297
uniprot id: A0A4X1W9V6
uniprot id: F1SR41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:KRT35
gene id: 9823:KRT35
uniprot id: A0A8D1J8J6
uniprot id: F1S0K7
names: Similarity
messages: Belongs to the intermediate filament family.

9823:QTRT2
gene id: 9823:QTRT2
uniprot id: A0A4X1SX99
uniprot id: A0A8D0JY76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9823:UCHL3
gene id: 9823:UCHL3
uniprot id: Q06AB3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C12 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3, and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome (By similarity).
messages: Inhibited by monoubiquitin and diubiquitin.
messages: Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits the hydrolyzing activity on other substrates.

9823:BPIFC
gene id: 9823:BPIFC
uniprot id: A0A4X1SXV5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9823:SERPINB1
gene id: 9823:SERPINB1
uniprot id: A0A4X1SRT1
uniprot id: M3TYG7
names: Similarity
messages: Belongs to the serpin family.

9823:DEF8
gene id: 9823:DEF8
uniprot id: A0A4X1TF08
uniprot id: F1S6M6
names: Similarity
messages: Belongs to the DEF8 family.

9823:HCRTR2
gene id: 9823:HCRTR2
uniprot id: O62809
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
messages: The N-terminal region is required for orexin signaling.

9823:OSBPL8
gene id: 9823:OSBPL8
uniprot id: A0A4X1VYM2
uniprot id: A0A4X1VZA8
uniprot id: A0A4X1W141
uniprot id: F1SGD5
uniprot id: I3LKX6
uniprot id: K9J6H2
names: Similarity
messages: Belongs to the OSBP family.

9823:EPOR
gene id: 9823:EPOR
uniprot id: B0ZYW8
uniprot id: Q9MYZ9
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
messages: Forms homodimers on EPO stimulation.
messages: Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein APS, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3 and CRKL. The N-terminal SH2 domain of PTPN6 binds Tyr-455 and inhibits signaling through dephosphorylation of JAK2. APS binding also inhibits the JAK-STAT signaling. Binding to PTPN11, preferentially through the N-terminal SH2 domain, promotes mitogenesis and phosphorylation of PTPN11. Binding of JAK2 (through its N-terminal) promotes cell-surface expression. Interaction with the ubiquitin ligase NOSIP mediates EPO-induced cell proliferation. Interacts with ATXN2L and INPP5D/SHIP1 (By similarity).
messages: Low expression at day 24 gestation in fetal liver. Expression increases dramatically thereafter to day 30. Levels then remain constant up to day 40.
messages: Membrane
messages: On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2. The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation. Phosphorylation on Tyr-455 is required for PTPN6 interaction, Tyr-427 for PTPN11. Tyr-427 is also required for SOCS3 binding, but Tyr-455/Tyr-457 motif is the preferred binding site (By similarity).
messages: Receptor for erythropoietin.
messages: Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: Ubiquitinated by NOSIP; appears to be either multi-monoubiquitinated or polyubiquitinated. Ubiquitination mediates proliferation and survival of EPO-dependent cells. Ubiquitination at Lys-282 mediates receptor internalization, whereas ubiquitination at Lys-454 promotes trafficking of activated receptors to the lysosomes for degradation (By similarity).

9823:TONSL
gene id: 9823:TONSL
uniprot id: A0A480U9Q8
uniprot id: A0A481CBQ9
uniprot id: A0A4X1UNE6
uniprot id: A0A8D0SVA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tonsoku family.
messages: Chromosome

9823:BCAP31
gene id: 9823:BCAP31
uniprot id: A0A4X1T1G4
uniprot id: F1S2A8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9823:GANAB
gene id: 9823:GANAB
uniprot id: A0A4X1VKG9
uniprot id: I3LNH3
uniprot id: P79403
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.
messages: Contains sialylated polysaccharide chains.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH). Binds glycosylated PTPRC.
messages: Melanosome

9823:DUSP13
gene id: 9823:DUSP13
uniprot id: A0A4X1SP77
uniprot id: A0A8D1D7P6
uniprot id: A0A8D1HFU2
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9823:LAMTOR1
gene id: 9823:LAMTOR1
uniprot id: A0A4X1V3R0
uniprot id: F2Z5W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9823:MLLT3
gene id: 9823:MLLT3
uniprot id: A0A287A4E4
uniprot id: A0A4X1W628
uniprot id: A0A4X1WD08
uniprot id: A0A4X1WD13
uniprot id: F1SNG3
names: Subcellular Location Annotation
messages: Nucleus

9823:PTBP1
gene id: 9823:PTBP1
uniprot id: A0A8D0J3K9
uniprot id: Q29099
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Monomer. Part of a ternary complex containing KHSRP, PTBP1, PTBP2 and HNRPH1. Interacts with RAVER1 and SFPQ (By similarity).
messages: Nucleus
messages: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.

9823:LOC100525298
gene id: 9823:LOC100525298
uniprot id: A0A4X1VDK4
uniprot id: A0A8D1A3U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GLTP
gene id: 9823:GLTP
uniprot id: P68266
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides (By similarity).
messages: Belongs to the GLTP family.
messages: Cytoplasm
messages: Monomer.

9823:GADD45A
gene id: 9823:GADD45A
uniprot id: Q15B93
names: Similarity
messages: Belongs to the GADD45 family.

9823:SPACA3
gene id: 9823:SPACA3
uniprot id: D5K889
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9823:DCP2
gene id: 9823:DCP2
uniprot id: A0A286ZYW5
uniprot id: A0A4X1U2G7
uniprot id: A0A8D0KDG0
uniprot id: A0A8D0Q7A5
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9823:TSPAN31
gene id: 9823:TSPAN31
uniprot id: A0A5G2R1G0
uniprot id: A0A8D0K2Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:INMT
gene id: 9823:INMT
uniprot id: A0A480ZLY1
uniprot id: A0A4X1SZZ4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9823:FAM183A
gene id: 9823:FAM183A
uniprot id: A0A8D0I0X9
uniprot id: F1SFB7
names: Similarity
messages: Belongs to the CFAP144 family.

9823:STARD6
gene id: 9823:STARD6
uniprot id: A0A8D1PAR7
uniprot id: F1S1Z6
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9823:EXO1
gene id: 9823:EXO1
uniprot id: A0A4X1T6P3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

9823:CYP2A19
gene id: 9823:CYP2A19
uniprot id: Q6YN43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9823:DGAT1
gene id: 9823:DGAT1
uniprot id: Q8MHZ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9823:TMEM206
gene id: 9823:TMEM206
uniprot id: A0A4X1TM74
uniprot id: F1S2V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9823:LOC100515529
gene id: 9823:LOC100515529
uniprot id: F1S6N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100626785
gene id: 9823:LOC100626785
uniprot id: A0ZQ09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ASNA1
gene id: 9823:ASNA1
uniprot id: A0A8D1SZ54
uniprot id: A0A8D1Y217
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

9823:PPP1R10
gene id: 9823:PPP1R10
uniprot id: Q767K9
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity).
messages: Nucleus
messages: Phosphorylated on Thr-398 by PKA within the region necessary for interaction with PPP1CA.
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).

9823:ERGIC2
gene id: 9823:ERGIC2
uniprot id: A0A4X1V1E8
uniprot id: A0A8D0LJ46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9823:CLCN5
gene id: 9823:CLCN5
uniprot id: Q9GKE7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (PubMed:10978325). Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable).
messages: Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation.

9823:LOC100517166
gene id: 9823:LOC100517166
uniprot id: A0A480ZG93
uniprot id: A0A4X1SG73
names: Similarity
messages: Belongs to the TMEM14 family.

9823:RGN
gene id: 9823:RGN
uniprot id: A0A4X1VIS8
uniprot id: A0A8D2A1A7
uniprot id: Q06AA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMP-30/CGR1 family.
messages: Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor is most likely Ca(2+) or Mg(2+).
messages: Cytoplasm
messages: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
messages: Monomer.

9823:BCORL1
gene id: 9823:BCORL1
uniprot id: A0A8D1PN92
uniprot id: F1RTH5
names: Similarity
messages: Belongs to the BCOR family.

9823:RPRD1A
gene id: 9823:RPRD1A
uniprot id: A0A4X1VAN7
uniprot id: A0A8D0HWL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

9823:FN3KRP
gene id: 9823:FN3KRP
uniprot id: A0A4X1U3C7
names: Similarity
messages: Belongs to the fructosamine kinase family.

9823:VAPB
gene id: 9823:VAPB
uniprot id: A5GFS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and late endosomes via interaction with STARD3 in a FFAT motif phosphorylation dependent manner. Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
messages: Homodimer, and heterodimer with VAPA. Interacts with VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27. Interacts with RMDN3. Interacts with KIF5A in a ZFYVE27-dependent manner. Interacts (via MSP domain) with STARD3 (via phospho-FFAT motif). Interacts with STARD3NL (via FFAT motif). Interacts with CERT1. Interacts with PLEKHA3 and SACM1L to form a ternary complex. Interacts with VPS13A (via FFAT motif). Interacts with RB1CC1 (via phosphorylated FFAT motif), MIGA2 (via phosphorylated FFAT motif), RMDN3 (via phosphorylated FFAT motif), OSBPL1A (via FFAT motif), KCNB1 (via phosphorylated FFAT motif) and KCNB2 (via phosphorylated FFAT motif).

9823:C6H1orf174
gene id: 9823:C6H1orf174
uniprot id: A0A4X1W8Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9823:SNX6
gene id: 9823:SNX6
uniprot id: A0A4X1T8K8
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9823:GNRHR2
gene id: 9823:GNRHR2
uniprot id: Q6QGW2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

9823:IDE
gene id: 9823:IDE
uniprot id: A0A287BBS8
uniprot id: A0A4X1UV52
uniprot id: A0A4X1UYL0
uniprot id: F1SC98
names: Similarity
messages: Belongs to the peptidase M16 family.

9823:C15H4orf47
gene id: 9823:C15H4orf47
uniprot id: A0A480TNM1
uniprot id: A0A4X1VW16
uniprot id: A0A8D0K329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP96 family.
messages: centrosome

9823:LOC100518623
gene id: 9823:LOC100518623
uniprot id: A0A4X1SHH2
uniprot id: A0A5G2QFL3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:KIAA1324
gene id: 9823:KIAA1324
uniprot id: A0A8D1Z3V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9823:GUSB
gene id: 9823:GUSB
uniprot id: Q4FAT7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

9823:SLC35B3
gene id: 9823:SLC35B3
uniprot id: A0A287A9F6
uniprot id: A0A4X1SH77
uniprot id: A0A8D1VXL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9823:ST14
gene id: 9823:ST14
uniprot id: A0A287AP26
uniprot id: A0A8D0XAY2
uniprot id: A0A8D1B9S9
uniprot id: F1S6D6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:PTPRB
gene id: 9823:PTPRB
uniprot id: A0A4X1VW45
uniprot id: F1SH38
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

9823:ZNF711
gene id: 9823:ZNF711
uniprot id: A0A4X1W508
uniprot id: A0A8D1RSG8
names: Subcellular Location Annotation
messages: Nucleus

9823:GGT1
gene id: 9823:GGT1
uniprot id: A0A4X1V1S5
uniprot id: A0A5K1UGB8
uniprot id: P20735
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by autocatalytic cleavage.
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cell membrane
messages: Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme.
messages: Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Heterodimer composed of the light and heavy chains. The active site is located in the light chain.
messages: Highly expressed in kidney. Detected at lower levels in liver, lung, plexus choroideus and brain capillary endothelial cells.
messages: Membrane
messages: N-glycosylated on both chains.

9823:RAB1A
gene id: 9823:RAB1A
uniprot id: Q52NJ2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: May interact with YIPF5. Interacts with C9orf72; the interaction mediates recruitment of RAB1A to the ATG1/ULK1 kinase complex. Interacts with GDI1; this promotes dissociation from membranes.
messages: Melanosome
messages: Membrane
messages: Phosphorylated by CDK1 kinase during mitosis.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Required to modulate the compacted morphology of the Golgi (By similarity). Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity).
messages: cytosol

9823:XIAP
gene id: 9823:XIAP
uniprot id: A0A4X1W670
uniprot id: A1YPR8
names: Similarity
messages: Belongs to the IAP family.

9823:HEXB
gene id: 9823:HEXB
uniprot id: D0G6X8
uniprot id: Q29548
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Addition of GM2A stimulates the hydrolysis of sulfated glycosphingolipid SM2 and the ganglioside GM2.
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Cortical granule
messages: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity).
messages: Lysosome
messages: There are 3 forms of beta-hexosaminidase: hexosaminidase A is an heterodimer composed of one subunit alpha and one subunit beta (chain A and B); hexosaminidase B is an homodimer of two beta subunits (two chains A and B); hexosaminidase S is a homodimer of two alpha subunits (By similarity). The composition of the dimer (isozyme A versus isozyme S) has a significant effect on the substrate specificity of the alpha subunit active site (By similarity).

9823:ADAM10
gene id: 9823:ADAM10
uniprot id: O77633
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Catalytically inactive when the propeptide is intact and associated with the mature enzyme (By similarity). The disintegrin and cysteine-rich regions modulate access of substrates to exerts an inhibitory effect on the cleavage of ADAM10 substrates (By similarity).
messages: Cell membrane
messages: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (By similarity). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (By similarity).
messages: Cytoplasm
messages: Expressed in chondrocytes.
messages: Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function (By similarity). Interacts with the clathrin adapter AP2 complex subunits AP2A1, AP2A2, AP2B1, and AP2M1; this interaction facilitates ADAM10 endocytosis from the plasma membrane during long-term potentiation in hippocampal neurons (By similarity). Interacts (via extracellular domain) with TSPAN33 (via extracellular domain) and (via cytoplasmic domain) with AFDN; interaction with TSPAN33 allows the docking of ADAM10 to zonula adherens through a PDZ11-dependent interaction between TSPAN33 and PLEKHA7 while interaction with AFDN locks ADAM10 at zonula adherens (By similarity). Forms a ternary complex composed of ADAM10, EPHA4 and CADH1; within the complex, ADAM10 cleaves CADH1 which disrupts adherens junctions (By similarity). Interacts with EPHA2 (By similarity). Interacts with NGF in a divalent cation-dependent manner (By similarity). Interacts with TSPAN14; the interaction promotes ADAM10 maturation and cell surface expression (By similarity). Interacts with TSPAN5, TSPAN10, TSPAN15, TSPAN17 and TSPAN33; these interactions regulate the ADAM10 substrate cleaving (By similarity). Interacts with DLG1; this interaction recruits ADAM10 to the cell membrane during long-term depression in hippocampal neurons (By similarity). Interacts (via extracellular domain) with BACE1 (via extracellular domain) (By similarity). Interacts with FAM171A1 (By similarity).
messages: Golgi apparatus membrane
messages: The precursor is cleaved by furin and PCSK7.
messages: The propeptide keeps the metalloprotease in a latent form via a cysteine switch mechanism. This mechanism may be mediated by a highly conserved cysteine (Cys-173) in the propeptide, which interacts and neutralizes the zinc-coordinating HEXGHXXGXXHD catalytic core of the metalloprotease domain. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: Up-regulared in chondrocytes culture by interleukin-1 and reduced by retinoic acid.
messages: adherens junction
messages: axon
messages: clathrin-coated vesicle
messages: dendrite

9823:APOB
gene id: 9823:APOB
uniprot id: A0A0F6TNY5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:PHOSPHO2
gene id: 9823:PHOSPHO2
uniprot id: A0A8D0P794
uniprot id: F1S1V3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9823:DNAJC5B
gene id: 9823:DNAJC5B
uniprot id: F1RTY8
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with the chaperone complex consisting of HSC70 and SGTA.
messages: Membrane
messages: Palmitoylated.

9823:HUWE1
gene id: 9823:HUWE1
uniprot id: A0A4X1V1Y8
uniprot id: F1RUH0
names: Similarity
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.

9823:RNF185
gene id: 9823:RNF185
uniprot id: A0A4X1V951
uniprot id: A0A8D0K0T3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

9823:CALB2
gene id: 9823:CALB2
uniprot id: E2IUK5
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9823:SFT2D1
gene id: 9823:SFT2D1
uniprot id: A0A4X1VWQ2
uniprot id: F1SBY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9823:ALKBH8
gene id: 9823:ALKBH8
uniprot id: A0A480X220
uniprot id: A0A8D0ZAQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

9823:SUPT4H1
gene id: 9823:SUPT4H1
uniprot id: A0A480VIE8
uniprot id: A0A4X1SL69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9823:LOC100157348
gene id: 9823:LOC100157348
uniprot id: A0A8D1QBA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ST3GAL4
gene id: 9823:ST3GAL4
uniprot id: B2ZCZ8
uniprot id: Q70E75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9823:HIP1R
gene id: 9823:HIP1R
uniprot id: A0A4X1UGG6
uniprot id: F1REX8
names: Similarity
messages: Belongs to the SLA2 family.

9823:SLC39A8
gene id: 9823:SLC39A8
uniprot id: A0A480EKF5
uniprot id: A0A8D0YLS2
names: Subcellular Location Annotation
messages: Membrane

9823:KCNK6
gene id: 9823:KCNK6
uniprot id: A0A287AWU0
uniprot id: A0A4X1TA95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9823:IFT20
gene id: 9823:IFT20
uniprot id: A0A480XEH4
uniprot id: A0A8D0MYT4
uniprot id: I3LK11
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9823:SLC5A5
gene id: 9823:SLC5A5
uniprot id: A0A8D1EXN7
uniprot id: Q9GJX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9823:CCT4
gene id: 9823:CCT4
uniprot id: A0A4X1WBL9
uniprot id: A0A8D0WWU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9823:CDH6
gene id: 9823:CDH6
uniprot id: A0A480PJS1
uniprot id: A0A8D0I4Q8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9823:SLC41A1
gene id: 9823:SLC41A1
uniprot id: A0A5G2QSK8
uniprot id: A0A8D0N7Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9823:GLRX
gene id: 9823:GLRX
uniprot id: F2XWZ9
uniprot id: P12309
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutaredoxin family.
messages: Cytoplasm
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9823:ARPC5
gene id: 9823:ARPC5
uniprot id: A0A4X1TX88
uniprot id: B5APV0
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9823:LOC100156293
gene id: 9823:LOC100156293
uniprot id: A0A4X1W7C1
uniprot id: F1SJE8
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

9823:SMARCB1
gene id: 9823:SMARCB1
uniprot id: A0A287A179
uniprot id: A0A4X1V165
uniprot id: A0A4X1V171
uniprot id: F2Z4X9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

9823:WARS2
gene id: 9823:WARS2
uniprot id: A0A8D1V9D8
uniprot id: B2ZF50
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9823:ASPN
gene id: 9823:ASPN
uniprot id: A0A8D1VZA0
uniprot id: F1SUE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9823:SEMA3E
gene id: 9823:SEMA3E
uniprot id: A0A8D0SUJ5
uniprot id: F1SBX2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:NDUFS1
gene id: 9823:NDUFS1
uniprot id: A0A4X1V1H9
uniprot id: A0A8D1F3I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

9823:CCDC39
gene id: 9823:CCDC39
uniprot id: A0A8D1PDR4
uniprot id: F1SGC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC39 family.
messages: cilium axoneme

9823:LOC100519675
gene id: 9823:LOC100519675
uniprot id: A0A4X1TPT1
uniprot id: A0A8D0RXZ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9823:BICD1
gene id: 9823:BICD1
uniprot id: A0A287AJ04
uniprot id: A0A4X1VPW9
uniprot id: A0A4X1VQ10
uniprot id: A0A4X1VQM7
uniprot id: A0A8D0X195
uniprot id: A0A8D0X8M9
uniprot id: A0A8D1A040
uniprot id: A0A8D1RDD7
names: Similarity
messages: Belongs to the BicD family.

9823:SLC13A2
gene id: 9823:SLC13A2
uniprot id: A0A480QMV3
uniprot id: A0A4X1TMC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9823:GATA5
gene id: 9823:GATA5
uniprot id: A0A8D1QB79
names: Subcellular Location Annotation
messages: Nucleus

9823:TNFRSF19
gene id: 9823:TNFRSF19
uniprot id: A0A8D1ZU11
uniprot id: F1RTN6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:MMP8
gene id: 9823:MMP8
uniprot id: A0A8D1XD16
uniprot id: F1SV69
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9823:PSMB4
gene id: 9823:PSMB4
uniprot id: A0A287B088
uniprot id: A0A8D0XSI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9823:CD8A
gene id: 9823:CD8A
uniprot id: A0A287A9Y5
uniprot id: A0A8D1HB99
uniprot id: Q6R2U9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:PFDN4
gene id: 9823:PFDN4
uniprot id: A0A8D1KSS6
uniprot id: A5GHK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9823:SLC16A11
gene id: 9823:SLC16A11
uniprot id: A0A4X1UZ62
uniprot id: A0A8D1I758
uniprot id: F1RFS3
names: Subcellular Location Annotation
messages: Membrane

9823:ADNP
gene id: 9823:ADNP
uniprot id: A0A4X1UJE1
uniprot id: A0A8D0UVH6
uniprot id: A5GHK7
names: Subcellular Location Annotation
messages: Nucleus

9823:SH3BGR
gene id: 9823:SH3BGR
uniprot id: A0A8D0WIU2
names: Similarity
messages: Belongs to the SH3BGR family.

9823:ABCG2
gene id: 9823:ABCG2
uniprot id: Q8MIB3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion (By similarity). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (By similarity). Mediates the secretion of the riboflavin and biotin vitamins into milk. Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (PubMed:12054514). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (By similarity). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus. May play a role in early stem cell self-renewal by blocking differentiation (By similarity).
messages: Cell membrane
messages: High expression in brain, kidney and lung. Also expressed in livere, colon, small intestine, heart, skeletal muscle, spleen, stomach and pancreas.
messages: Homodimer; disulfide-linked. The minimal functional unit is a homodimer, but the major oligomeric form in plasma membrane is a homotetramer with possibility of higher order oligomerization up to homododecamers.
messages: Mitochondrion membrane
messages: N-glycosylated. Glycosylation-deficient ABCG2 is normally expressed and functional.
messages: Phosphorylated. Phosphorylation may regulate the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter.
messages: The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.

9823:DPF2
gene id: 9823:DPF2
uniprot id: A0A4X1UUR7
uniprot id: A0A8D0U3A5
names: Similarity
messages: Belongs to the requiem/DPF family.

9823:GRHL2
gene id: 9823:GRHL2
uniprot id: A0A8D1BQM0
names: Subcellular Location Annotation
messages: Nucleus

9823:TOMM20
gene id: 9823:TOMM20
uniprot id: A0A4X1UGW3
uniprot id: A0A8D0INM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:MRPL32
gene id: 9823:MRPL32
uniprot id: A0A287B1Q6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9823:GCNT1
gene id: 9823:GCNT1
uniprot id: A0A4X1W2A6
uniprot id: F1SIN0
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9823:PIWIL1
gene id: 9823:PIWIL1
uniprot id: D9YJ48
names: Similarity
messages: Belongs to the argonaute family.

9823:ICMT
gene id: 9823:ICMT
uniprot id: A0A481C9N4
uniprot id: A0A4X1W840
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:ELMO3
gene id: 9823:ELMO3
uniprot id: A0A480SAH9
uniprot id: A0A8D1T6H7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9823:ORAI1
gene id: 9823:ORAI1
uniprot id: D3U7X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9823:LOC110255216
gene id: 9823:LOC110255216
uniprot id: F1RML5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100523177
gene id: 9823:LOC100523177
uniprot id: A0A286ZRW2
uniprot id: A0A4X1W2L0
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9823:IL6ST
gene id: 9823:IL6ST
uniprot id: A1EHE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9823:MAPK8
gene id: 9823:MAPK8
uniprot id: A0A480EHQ8
uniprot id: A0A4X1VFI4
uniprot id: A0A5G2Q9X6
uniprot id: K7GRS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9823:RPL26
gene id: 9823:RPL26
uniprot id: A0A4X1V977
uniprot id: I3L7Y1
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9823:MTRF1L
gene id: 9823:MTRF1L
uniprot id: A0A8D0YTZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9823:LOC100739396
gene id: 9823:LOC100739396
uniprot id: A0A4X1VDT0
uniprot id: F1RSF6
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

9823:POLD2
gene id: 9823:POLD2
uniprot id: A0A480YVX5
uniprot id: A0A8D0RNE6
uniprot id: A0A8D2CD08
uniprot id: F1SSF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

9823:C5
gene id: 9823:C5
uniprot id: Q6VPV1
names: Subcellular Location Annotation
messages: Secreted

9823:CHRNB3
gene id: 9823:CHRNB3
uniprot id: I3LLF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:DMRT2
gene id: 9823:DMRT2
uniprot id: A0A480RGK4
uniprot id: A0A4X1W5X0
uniprot id: A0A4X1W737
uniprot id: A0A8W4FMU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9823:LOC100620470
gene id: 9823:LOC100620470
uniprot id: A0A4X1W6H0
uniprot id: A0A8D1CFQ7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:LOC100359361
gene id: 9823:LOC100359361
uniprot id: A0A8D0MED0
uniprot id: D3K5K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9823:GDE1
gene id: 9823:GDE1
uniprot id: A0A8D0Y3L0
uniprot id: I3LLY2
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9823:LOC100523054
gene id: 9823:LOC100523054
uniprot id: A0A287AHG6
uniprot id: A0A8D0RXK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:TRH
gene id: 9823:TRH
uniprot id: A0A4X1UCE1
uniprot id: F1SPI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

9823:HCFC1
gene id: 9823:HCFC1
uniprot id: A0A480J3L4
names: Subcellular Location Annotation
messages: Nucleus

9823:SGCE
gene id: 9823:SGCE
uniprot id: B8Y4S6
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

9823:ABCD1
gene id: 9823:ABCD1
uniprot id: A0A8D0TH65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9823:SZRD1
gene id: 9823:SZRD1
uniprot id: A0A287AWQ5
uniprot id: A0A8D0M0D6
names: Similarity
messages: Belongs to the SZRD1 family.

9823:HSPE1
gene id: 9823:HSPE1
uniprot id: A0A8D1F5H5
uniprot id: Q6WSP6
names: Similarity
messages: Belongs to the GroES chaperonin family.

9823:RPL32
gene id: 9823:RPL32
uniprot id: Q6QAT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL32 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9823:ANPEP
gene id: 9823:ANPEP
uniprot id: A0A4X1U246
uniprot id: K7GMF9
uniprot id: P15145
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) In case of porcine transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCoV) infections, serves as a receptor for TGEV and PRCoV spike glycoprotein in a species-specific manner.
messages: (Microbial infection) Interacts with TGEV and PRCoV spike glycoprotein.
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met-enkephalin but not cholecystokinin CCK8, neuromedin C (GRP-10), somatostatin-14, substance P and vasoactive intestinal peptide (PubMed:8963385). May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).
messages: Cell membrane
messages: Homodimer. Interacts with SLC6A19 (By similarity).
messages: May undergo proteolysis and give rise to a soluble form.
messages: Membrane
messages: N- and O-glycosylated.
messages: Sulfated.

9823:MEP1B
gene id: 9823:MEP1B
uniprot id: A0A8D1C3S6
uniprot id: F1SAL4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:LAMTOR4
gene id: 9823:LAMTOR4
uniprot id: A0A8D0HMM5
names: Similarity
messages: Belongs to the LAMTOR4 family.

9823:TNFSF4
gene id: 9823:TNFSF4
uniprot id: A0A8D0JZB1
uniprot id: Q4QTJ8
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:SLC30A6
gene id: 9823:SLC30A6
uniprot id: A0A8D1ADK8
uniprot id: B6V6V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9823:KIF20B
gene id: 9823:KIF20B
uniprot id: A0A480QVY1
uniprot id: A0A480ZX77
uniprot id: A0A4X1V1I0
uniprot id: A0A4X1V2Z5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:GJA10
gene id: 9823:GJA10
uniprot id: A0A480DJL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:MYH1
gene id: 9823:MYH1
uniprot id: Q9TV61
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9823:AIFM1
gene id: 9823:AIFM1
uniprot id: A0A068CA64
uniprot id: A0A4X1W3S1
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

9823:NUDT21
gene id: 9823:NUDT21
uniprot id: A0A286ZWI2
uniprot id: A0A8D0ZM03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

9823:SUMO2
gene id: 9823:SUMO2
uniprot id: C7S2Z6
uniprot id: P61958
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
messages: Interacts with SAE2 and UBE2I. Interacts with ZNF451. Identified in a complex with ZNF451 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 and SOBP (via SIM domains). Interacts with MTA1 (By similarity). Interacts with HINT1 (By similarity). Interacts with GCNA (via SIM domains); this interaction allows the GCNA recruitment to DPCs sites (By similarity).
messages: Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.
messages: Nucleus
messages: PML body
messages: Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4 (By similarity).
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity).

9823:FSHR
gene id: 9823:FSHR
uniprot id: A0A8D1R806
uniprot id: I3L9Z2
uniprot id: P49059
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation (By similarity).
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation.
messages: Membrane
messages: N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.
messages: Sulfated.

9823:TMEM33
gene id: 9823:TMEM33
uniprot id: A0A4X1UR13
uniprot id: A0A8D1R4B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9823:NAXD
gene id: 9823:NAXD
uniprot id: A0A480VIL3
uniprot id: A0A4X1U1Z0
uniprot id: A0A4X1U774
uniprot id: I3LS60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Mitochondrion

9823:VIL1
gene id: 9823:VIL1
uniprot id: A0A480TKM7
uniprot id: A0A8D1R845
names: Similarity
messages: Belongs to the villin/gelsolin family.

9823:MMP16
gene id: 9823:MMP16
uniprot id: A0A287AKC1
uniprot id: A0A8D1LEA6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9823:PDF
gene id: 9823:PDF
uniprot id: A0A480VWD0
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

9823:PARL
gene id: 9823:PARL
uniprot id: A0A5G2Q7L9
names: Subcellular Location Annotation
messages: Membrane

9823:GLS2
gene id: 9823:GLS2
uniprot id: A0A8D0P4A7
uniprot id: A0A8D1Q6Y5
uniprot id: F1SLB4
names: Similarity
messages: Belongs to the glutaminase family.

9823:MKS1
gene id: 9823:MKS1
uniprot id: A0A4X1SK90
names: Subcellular Location Annotation
messages: cilium basal body

9823:NUBP2
gene id: 9823:NUBP2
uniprot id: A0A4X1VT84
uniprot id: A0A8D1JF77
uniprot id: A0A8D1SK94
uniprot id: F1RG29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9823:SLC12A5
gene id: 9823:SLC12A5
uniprot id: A0A287BS17
uniprot id: A0A4X1U3U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9823:LOC100622380
gene id: 9823:LOC100622380
uniprot id: A0A4X1TB72
uniprot id: A0A5G2QL90
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MRPL15
gene id: 9823:MRPL15
uniprot id: A0A8D0HMG9
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9823:GHITM
gene id: 9823:GHITM
uniprot id: A0A8D1XT50
uniprot id: F1SEQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9823:RAP2B
gene id: 9823:RAP2B
uniprot id: Q06AU2
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by the guanine nucleotide-exchange factors RAPGEF3 and RAPGEF4 in a cAMP-dependent manner. Nucleotide exchange is also specifically stimulated by RAPGEF5, RASGEF1A and RASGEF1B (By similarity).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Interacts (GTP-bound form) with RUNDC3A. Interacts with PLCE1. Interacts with ARHGAP29, SGSM1, SGSM2 and SGSM3. Interacts (GTP-bound form preferentially) with TNIK (via the CNH domain); the interaction is direct and recruits RAP2A to the E3 ubiquitin ligase NEDD4. Interacts with MINK1. Interacts (GTP-bound form preferentially) with MAP4K4. Interacts with cytoskeletal actin. Interacts with RGS14; the interaction is GTP-dependent (By similarity).
messages: Midbody
messages: Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (By similarity).
messages: The effector domain mediates the interaction with RUNDC3A.
messages: Ubiquitinated; undergoes 'Lys-63' monoubiquitination and diubiquitination by NEDD4. Multiple lysine residues are probably modified. Ubiquitination requires TNIK, prevents interaction with effectors and inactivates RAP2A (By similarity).

9823:SYNDIG1L
gene id: 9823:SYNDIG1L
uniprot id: A0A4X1THB5
uniprot id: A0A4X1TJE8
uniprot id: A0A8D0LW33
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:SNPH
gene id: 9823:SNPH
uniprot id: A0A8D0VED3
names: Subcellular Location Annotation
messages: Membrane

9823:EFNA4
gene id: 9823:EFNA4
uniprot id: A0A286ZW63
uniprot id: A0A4X1W227
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:NDFIP2
gene id: 9823:NDFIP2
uniprot id: A0A8D0SUG3
uniprot id: F1RP69
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9823:AMIGO2
gene id: 9823:AMIGO2
uniprot id: A0A480E129
uniprot id: A0A8D0U080
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9823:ADAM2
gene id: 9823:ADAM2
uniprot id: A0A8D1KBK0
uniprot id: Q866A8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:BHLHB9
gene id: 9823:BHLHB9
uniprot id: A0A4X1VZB2
uniprot id: F1RYE8
names: Similarity
messages: Belongs to the GPRASP family.

9823:LOC100152150
gene id: 9823:LOC100152150
uniprot id: A0A8D0SUD3
uniprot id: F1RX88
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:TNNT1
gene id: 9823:TNNT1
uniprot id: A0A4X1V7C9
uniprot id: Q75ZZ6
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9823:FAR2
gene id: 9823:FAR2
uniprot id: A0A287AZP5
uniprot id: A0A4X1V3D0
uniprot id: A0A8D0PX71
uniprot id: A0A8D1AVY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9823:NPBWR1
gene id: 9823:NPBWR1
uniprot id: A0A4X1T4V5
uniprot id: A0A8W4F7A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:SLC25A15
gene id: 9823:SLC25A15
uniprot id: A0A4X1SS99
uniprot id: A0A8D0RZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:PHKG1
gene id: 9823:PHKG1
uniprot id: A0A024BTL2
uniprot id: A0A8D0S2H2
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9823:PPIL1
gene id: 9823:PPIL1
uniprot id: A0A4X1STN7
uniprot id: A0A8D0LQF7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9823:HPX
gene id: 9823:HPX
uniprot id: P50828
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Expressed by the liver and secreted in plasma.
messages: Lacks the conserved His heme iron ligand in position 81. There is a Gln in this position.
messages: Secreted
messages: The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity).

9823:VIPR2
gene id: 9823:VIPR2
uniprot id: E0Y442
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9823:ACP5
gene id: 9823:ACP5
uniprot id: P09889
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 2 iron ions per subunit.
messages: Secreted
messages: Uteroferrin is a phosphoprotein phosphatase, synthesized in response to progesterone. It appears to function in transplacental transport of iron in pig.

9823:CD82
gene id: 9823:CD82
uniprot id: A0A4X1SFI7
uniprot id: B7ZEQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:RCAN2
gene id: 9823:RCAN2
uniprot id: A0A4X1V5F5
uniprot id: A0A8D1ZM99
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9823:SAA3
gene id: 9823:SAA3
uniprot id: Q2HXZ9
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9823:LOC100521229
gene id: 9823:LOC100521229
uniprot id: I3LHU5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.

9823:HTR1F
gene id: 9823:HTR1F
uniprot id: A0A4X1UP98
uniprot id: Q9GKI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

9823:SRF
gene id: 9823:SRF
uniprot id: A0A8D1L599
uniprot id: F1RRM9
names: Subcellular Location Annotation
messages: Nucleus

9823:SFT2D2
gene id: 9823:SFT2D2
uniprot id: A0A287AHI5
uniprot id: A0A4X1V3M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9823:DOK4
gene id: 9823:DOK4
uniprot id: A0A480SYL8
uniprot id: A0A4X1UYW0
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9823:PADI2
gene id: 9823:PADI2
uniprot id: A0A5K1VJD9
uniprot id: A0A8D1ULA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9823:GJC1
gene id: 9823:GJC1
uniprot id: A4GVD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:FAAH
gene id: 9823:FAAH
uniprot id: A0A8D1FAJ9
uniprot id: Q9TUI8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidase family.
messages: Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:10526230, PubMed:12664593). Also catalyzes the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:10526230, PubMed:12664593). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: inhibited by trifluoromethyl ketone.

9823:RGR
gene id: 9823:RGR
uniprot id: A0A4X1SDS0
uniprot id: A0A8D0JFW7
names: Subcellular Location Annotation
messages: Membrane

9823:MDK
gene id: 9823:MDK
uniprot id: A0A8D0TPY6
uniprot id: A0A8D1BER4
uniprot id: A0A8D1BSI8
uniprot id: A0A8D1G462
names: Similarity
messages: Belongs to the pleiotrophin family.

9823:SERPINA7
gene id: 9823:SERPINA7
uniprot id: Q9TT35
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Expressed by the liver and secreted in plasma.
messages: Major thyroid hormone transport protein in serum.
messages: Secreted
messages: The allele with Asn-245 has a significantly greater affinity for thyroxine than the His-245 allele found in Meishan boars. This polymorphism is a candidate for the causative variation affecting testis size in boars.

9823:LOC100622230
gene id: 9823:LOC100622230
uniprot id: A0A4X1V3S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CSAD
gene id: 9823:CSAD
uniprot id: A0A8D0PLY3
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9823:LOC100620992
gene id: 9823:LOC100620992
uniprot id: A0A286ZYR2
uniprot id: A0A287B5Z5
uniprot id: A0A8D1PNH9
uniprot id: A0A8D1X5T0
uniprot id: A0A8D2BX37
uniprot id: I3LJN6
names: Subcellular Location Annotation
messages: Nucleus

9823:PSMC1
gene id: 9823:PSMC1
uniprot id: A0A4X1ST93
uniprot id: F2Z5J1
names: Similarity
messages: Belongs to the AAA ATPase family.

9823:FOLR1
gene id: 9823:FOLR1
uniprot id: A0A287BLX2
uniprot id: A0A4X1UY18
uniprot id: A0A4X1V387
uniprot id: A0A8D1D1N2
uniprot id: Q9XSH0
uniprot id: Q9XSH1
names: Similarity
messages: Belongs to the folate receptor family.

9823:GNG3
gene id: 9823:GNG3
uniprot id: A0A286ZLJ8
uniprot id: A0A8D0VJB8
uniprot id: A0A8D1BZR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9823:CHST3
gene id: 9823:CHST3
uniprot id: A0A4X1T9E4
uniprot id: A0A8D1TAJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9823:DHX58
gene id: 9823:DHX58
uniprot id: A0A4X1U1Q9
uniprot id: E3NZJ4
uniprot id: F1S0P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9823:CAPN5
gene id: 9823:CAPN5
uniprot id: A0A8D1ZTX6
names: Similarity
messages: Belongs to the peptidase C2 family.

9823:PPP1R3C
gene id: 9823:PPP1R3C
uniprot id: A0A4X1V0S1
uniprot id: A0A8D1NKW8
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9823:HOXC13
gene id: 9823:HOXC13
uniprot id: A0A4X1WBW3
uniprot id: F1SFN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9823:APOA1
gene id: 9823:APOA1
uniprot id: P18648
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Glycosylated.
messages: Homodimer (By similarity). Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity). Interacts with NAXE and YJEFN3 (By similarity).
messages: Liver apoa-I expressed in fetal, newborn and suckling animals. Intestinal apoA-I only expressed in postpartum animals.
messages: Major protein of plasma HDL, also found in chylomicrons. Synthesized predominantly in the intestine and the liver.
messages: Palmitoylated.
messages: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
messages: Phosphorylation sites are present in the extracellular medium.
messages: Secreted

9823:DUOXA2
gene id: 9823:DUOXA2
uniprot id: A0A8D0M717
uniprot id: A0A8D0M8J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9823:TLX3
gene id: 9823:TLX3
uniprot id: A0A8D1GR04
names: Subcellular Location Annotation
messages: Nucleus

9823:KREMEN1
gene id: 9823:KREMEN1
uniprot id: A0A480W7P4
uniprot id: A0A8D1YCT1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

9823:AQP6
gene id: 9823:AQP6
uniprot id: A0A8D1T7R8
uniprot id: B2MUK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:SEC23B
gene id: 9823:SEC23B
uniprot id: A0A4X1V0I4
uniprot id: F1SBH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9823:RCE1
gene id: 9823:RCE1
uniprot id: A0A287A799
uniprot id: A0A4X1TD43
uniprot id: A0A4X1TD88
uniprot id: A0A8D1YL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:MYOZ3
gene id: 9823:MYOZ3
uniprot id: Q1AG05
names: Similarity
messages: Belongs to the myozenin family.

9823:ZBTB8OS
gene id: 9823:ZBTB8OS
uniprot id: A0A8D1JLQ2
uniprot id: I3L7E1
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

9823:OPRL1
gene id: 9823:OPRL1
uniprot id: P79292
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Detected in brain cortex, stomach, ileum, jejunum and colon.
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin (By similarity).
messages: Phosphorylation at Ser-363 requires GRK3.

9823:GABARAPL2
gene id: 9823:GABARAPL2
uniprot id: A0A8D0THN7
uniprot id: A0A8W4FN23
names: Similarity
messages: Belongs to the ATG8 family.

9823:CARMIL1
gene id: 9823:CARMIL1
uniprot id: A0A480IRX4
uniprot id: A0A8D1GVF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9823:SPATA6
gene id: 9823:SPATA6
uniprot id: A0A8D1VWC6
uniprot id: D5K8A1
names: Similarity
messages: Belongs to the SPATA6 family.

9823:SEZ6L2
gene id: 9823:SEZ6L2
uniprot id: A0A480TLM4
uniprot id: A0A4X1U052
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100517101
gene id: 9823:LOC100517101
uniprot id: A0A287AX84
names: Similarity
messages: Belongs to the PRAME family.

9823:SMC3
gene id: 9823:SMC3
uniprot id: A0A4X1TFF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

9823:STK38
gene id: 9823:STK38
uniprot id: A0A4X1SUS9
uniprot id: A0A8D1YB09
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:POLR1C
gene id: 9823:POLR1C
uniprot id: A0A286ZY98
uniprot id: A0A5G2R496
uniprot id: A0A8D1DU83
uniprot id: A0A8D1V2J3
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9823:MAGED1
gene id: 9823:MAGED1
uniprot id: Q6ITT4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA (By similarity).
messages: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed (By similarity).
messages: Nucleus

9823:POLR2K
gene id: 9823:POLR2K
uniprot id: A0A4X1TRS6
uniprot id: A0A8D0JYF1
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9823:LOC100736951
gene id: 9823:LOC100736951
uniprot id: A0A4X1T4B8
uniprot id: F1SNU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9823:TRPV2
gene id: 9823:TRPV2
uniprot id: F1SDE4
names: Subcellular Location Annotation
messages: Membrane

9823:DNTTIP1
gene id: 9823:DNTTIP1
uniprot id: A0A4X1U011
uniprot id: F1SC86
names: Subcellular Location Annotation
messages: Nucleus

9823:PSD3
gene id: 9823:PSD3
uniprot id: A0A287AHS5
uniprot id: A0A8D0KAU8
uniprot id: I3L6H3
names: Subcellular Location Annotation
messages: Membrane
messages: ruffle membrane

9823:MRPL9
gene id: 9823:MRPL9
uniprot id: A0A287BLN5
uniprot id: I3LR45
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

9823:SGCA
gene id: 9823:SGCA
uniprot id: A0A4X1URV3
uniprot id: B8Y4S3
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

9823:RNF20
gene id: 9823:RNF20
uniprot id: A0A4X1VEK1
uniprot id: A0A8D1UV13
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9823:POSTN
gene id: 9823:POSTN
uniprot id: A0A4X1SVF9
uniprot id: A0A8D0WEG1
uniprot id: A0A8D1IGT6
uniprot id: D3K5K1
uniprot id: I3LDM1
names: Subcellular Location Annotation
messages: extracellular matrix

9823:SOAT1
gene id: 9823:SOAT1
uniprot id: A0A8D0LQT2
uniprot id: I3L5S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:PRICKLE2
gene id: 9823:PRICKLE2
uniprot id: A0A8D1R5Z4
uniprot id: A0A8D1TDN5
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9823:ANGPT1
gene id: 9823:ANGPT1
uniprot id: Q9BDY8
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity).
messages: Glycosylated.
messages: Secreted

9823:SYPL2
gene id: 9823:SYPL2
uniprot id: A0A5G2R2H0
uniprot id: A0A8D0WHT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9823:TRNAU1AP
gene id: 9823:TRNAU1AP
uniprot id: A0A287AQ52
uniprot id: A0A8D0RAW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9823:NUDT3
gene id: 9823:NUDT3
uniprot id: A0A0E3KLW5
uniprot id: A0A4X1T4G5
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9823:TAF1A
gene id: 9823:TAF1A
uniprot id: A0A8X9AEX9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9823:ADAMDEC1
gene id: 9823:ADAMDEC1
uniprot id: A0A8D1BA64
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:GPAT4
gene id: 9823:GPAT4
uniprot id: A0A4X1U8B9
uniprot id: B8XTR4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9823:IRAK4
gene id: 9823:IRAK4
uniprot id: A0A8D1BGX3
uniprot id: A9QT42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9823:SCNM1
gene id: 9823:SCNM1
uniprot id: A0A4X1W1P3
uniprot id: F1SSY2
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: nucleoplasm

9823:FFAR1
gene id: 9823:FFAR1
uniprot id: A0A4X1TJT4
uniprot id: F1RM69
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:OSGEP
gene id: 9823:OSGEP
uniprot id: A0A8D0J405
uniprot id: F1S8H4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleus

9823:LOC100522141
gene id: 9823:LOC100522141
uniprot id: A0A4X1SS80
uniprot id: F1RHC3
names: Similarity
messages: Belongs to the TTC9 family.

9823:EWSR1
gene id: 9823:EWSR1
uniprot id: A0A4X1VEY0
uniprot id: A0A4X1VHL7
uniprot id: A0A5G2RG83
uniprot id: A0A8D0PSR4
uniprot id: A0A8D2AKJ7
uniprot id: G8ENL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9823:VAT1
gene id: 9823:VAT1
uniprot id: A0A8D0YLH0
uniprot id: I3L9V2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9823:C2H5orf24
gene id: 9823:C2H5orf24
uniprot id: A0A4X1V145
uniprot id: A0A4X1V155
uniprot id: A0A5G2Q9T2
uniprot id: A0A8D1DJQ2
names: Similarity
messages: Belongs to the UPF0461 family.

9823:TVP23A
gene id: 9823:TVP23A
uniprot id: A0A4X1VQS6
uniprot id: A0A8D1CXG5
uniprot id: I3LSV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9823:CASS4
gene id: 9823:CASS4
uniprot id: A0A4X1UQ43
uniprot id: A5GFW5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAS family.
messages: Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading (By similarity).
messages: Interacts (via SH3 domain) with PTK2/FAK1 (via C-terminus).
messages: Phosphorylated on tyrosines by SRC.
messages: The SH3 domain interacts with the C-terminal region of PTK2/FAK1.
messages: cytoskeleton
messages: focal adhesion

9823:AMBN
gene id: 9823:AMBN
uniprot id: Q28989
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Ameloblast-specific. Located at the Tomes processes of secretory ameloblasts and in the sheath space between rod-interrod enamel.
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

9823:ARMCX2
gene id: 9823:ARMCX2
uniprot id: A0A4X1W3V7
uniprot id: K7GNG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9823:NUDT6
gene id: 9823:NUDT6
uniprot id: A0A480E320
uniprot id: A0A5G2QE17
uniprot id: A0A8D0K9P0
uniprot id: A0A8D0LVW9
uniprot id: A0A8D0N0E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Cytoplasm
messages: May contribute to the regulation of cell proliferation.
messages: Mitochondrion
messages: Monomer and homodimer.
messages: Nucleus

9823:NR0B1
gene id: 9823:NR0B1
uniprot id: P79386
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2 (By similarity). Interacts with ESRRB; represses ESRRB activity at the GATA6 promoter (By similarity).
messages: Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1 and NROB2 through its N-terminal LXXLL motifs (By similarity).
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).

9823:EPS8L3
gene id: 9823:EPS8L3
uniprot id: A0A4X1TF84
names: Similarity
messages: Belongs to the EPS8 family.

9823:LOC100522145
gene id: 9823:LOC100522145
uniprot id: A0A8D0ZSS6
uniprot id: F1SAG6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:ARL6IP5
gene id: 9823:ARL6IP5
uniprot id: Q56P28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homodimer. Heterodimer with ARL6IP1. Forms multimers. Interacts with ARL6. Interacts with prenylated RAB1A and RAB3A. Interacts with SLC1A1/EAAC1. Interacts with RTN2 (via first transmembrane domain). Does not interact with VAMP1, VAMP2 or VAMP3.
messages: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum.
messages: cytoskeleton

9823:HSPB9
gene id: 9823:HSPB9
uniprot id: A0A4X1U196
uniprot id: F1S0Q1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

9823:VRTN
gene id: 9823:VRTN
uniprot id: E1CHH8
names: Similarity
messages: Belongs to the vertnin family.

9823:INPP5K
gene id: 9823:INPP5K
uniprot id: D7P0F2
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9823:SPIB
gene id: 9823:SPIB
uniprot id: A0A4X1VVR0
uniprot id: A0A8D1JXL3
uniprot id: A0A8W4FGP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:TASP1
gene id: 9823:TASP1
uniprot id: A0A287AGF4
uniprot id: A0A4X1UTB2
uniprot id: A0A4X1UWG7
uniprot id: A0A8D1HVK1
uniprot id: A0A8D1LQT1
uniprot id: A0A8D1RYU6
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9823:LOC100623905
gene id: 9823:LOC100623905
uniprot id: A0A4X1SVN5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ECI1
gene id: 9823:ECI1
uniprot id: M9TGS8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9823:ART1
gene id: 9823:ART1
uniprot id: A0A8D1WFF8
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9823:UNC45B
gene id: 9823:UNC45B
uniprot id: A9X3M3
names: Subcellular Location Annotation
messages: A band
messages: Z line
messages: perinuclear region

9823:YIPF6
gene id: 9823:YIPF6
uniprot id: A0A4X1VVT6
uniprot id: F1RZ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:COPS4
gene id: 9823:COPS4
uniprot id: A7Y521
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN4 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).
messages: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (By similarity). In the complex, it probably interacts directly with COPS1, COPS2, COPS3, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8 (By similarity). Interacts with TOR1A; the interaction is direct and associates TOR1A and SNAPIN with the CSN complex (By similarity). Interacts with STON2; controls STON2 neddylation levels (By similarity). Interacts with ERCC6 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: synaptic vesicle

9823:HMGN2
gene id: 9823:HMGN2
uniprot id: P80272
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylation favors cytoplasmic localization.

9823:PGC
gene id: 9823:PGC
uniprot id: A0A286ZP41
uniprot id: A0A4X1SIV5
uniprot id: A0A8D1FKU8
uniprot id: A0A8D1VT43
names: Similarity
messages: Belongs to the peptidase A1 family.

9823:SLC26A5
gene id: 9823:SLC26A5
uniprot id: A0A4X1VAZ2
uniprot id: A0A8D2CGV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Voltage-sensitive motor protein that drives outer hair cell (OHC) electromotility (eM) and participates in sound amplification in the hearing organ. Converts changes in the transmembrane electric potential into mechanical displacements resulting in the coupling of its expansion to movement of a charged voltage sensor across the lipid membrane. The nature of the voltage sensor is not completely clear, and two models compete. In the first model, acts as an incomplete transporter where intracellular chloride anion acts as extrinsic voltage sensor that drives conformational change in the protein which is sufficient to produce a length change in the plane of the membrane and hence in the length of the OHC. The second model in which multiple charged amino acid residues are distributed at the intracellular and extracellular membrane interfaces that form an intrinsic voltage sensor, whose movement produces the non-linear capacitance (NLC). However, the effective voltage sensor may be the result of a hybrid voltage sensor, assembled from intrinsic charge (charged residues) and extrinsic charge (bound anion). Notably, binding of anions to the anion-binding pocket partially neutralizes the intrinsic positive charge rather than to form an electrically negative sensor, therefore remaining charge may serve as voltage sensor that, after depolarization, moves from down (expanded state) to up (contracted) conformation, which is accompanied by an eccentric contraction of the intermembrane cross-sectional area of the protein as well as a major increase in the hydrophobic thickness of the protein having as consequences the plasma membrane thickening and the cell contraction after membrane depolarization. The anion-binding pocket transits from the inward-open (Down) state, where it is exposed toward the intracellular solvent in the absence of anion, to the occluded (Up) state upon anion binding. Salicylate competes for the anion-binding site and inhibits the voltage-sensor movement, and…

9823:CCDC34
gene id: 9823:CCDC34
uniprot id: A0A4X1SXC4
uniprot id: A0A8D1U253
names: Subcellular Location Annotation
messages: flagellum

9823:CLEC12B
gene id: 9823:CLEC12B
uniprot id: A0A8D0PPP8
uniprot id: A0A8D1SNW2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:SEMA6C
gene id: 9823:SEMA6C
uniprot id: A0A480LR33
uniprot id: A0A480V9J4
uniprot id: A0A8D1AV11
uniprot id: A0A8D1I442
uniprot id: A0A8D1PYC4
uniprot id: F1SSX9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:PSMC3IP
gene id: 9823:PSMC3IP
uniprot id: A0A4X1U064
uniprot id: F1S1D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

9823:ACKR4
gene id: 9823:ACKR4
uniprot id: A0A8D0WK05
uniprot id: A3F9C6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:HDGFL2
gene id: 9823:HDGFL2
uniprot id: A0A8D1EHK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9823:TOMM7
gene id: 9823:TOMM7
uniprot id: A1XQS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom7 family.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).
messages: Mitochondrion outer membrane
messages: Required for assembly and stability of the TOM complex (By similarity). Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity).

9823:VGLL3
gene id: 9823:VGLL3
uniprot id: A0A4X1UMY1
uniprot id: A0A4X1UNS4
uniprot id: A0A8D0PJX7
uniprot id: B8Y4S7
uniprot id: B8Y4S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9823:RGS16
gene id: 9823:RGS16
uniprot id: F1S668
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Gets inactivated and/or degraded by porcine circovirus 2 ORF3 protein, leading to enhanced expression of IL-6 and IL-8 in infected lymphocytes. This would explain chronic inflammatory response of PCV2 infected pigs.
messages: (Microbial infection) Interacts with porcine circovirus 2 ORF3 protein.
messages: Interacts with GNAI1 and GNAQ. Interacts with GNAI3, GNAI3 and GNAO1.
messages: Membrane
messages: Palmitoylated on Cys-2 and/or Cys-12.
messages: Phosphorylated. Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1.
messages: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals.

9823:LOC100127131
gene id: 9823:LOC100127131
uniprot id: A0A4X1WCL3
uniprot id: F1SHC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9823:LOC100524508
gene id: 9823:LOC100524508
uniprot id: A0A4X1TGR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TPO
gene id: 9823:TPO
uniprot id: D6NHN4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Interacts with DUOX1, DUOX2 and CYBA.
messages: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:YDJC
gene id: 9823:YDJC
uniprot id: A0A4X1V0J3
uniprot id: F1RKY7
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

9823:GBP1
gene id: 9823:GBP1
uniprot id: B2XWS1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9823:RBM46
gene id: 9823:RBM46
uniprot id: A0A287AN41
uniprot id: A0A8D0Z7G5
names: Subcellular Location Annotation
messages: Cytoplasm

9823:GBX1
gene id: 9823:GBX1
uniprot id: A0A287AZC2
names: Subcellular Location Annotation
messages: Nucleus

9823:CA3
gene id: 9823:CA3
uniprot id: Q5S1S4
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Inhibited by acetazolamide.
messages: Reversible hydration of carbon dioxide.
messages: S-glutathionylated in hepatocytes under oxidative stress.
messages: S-thiolated both by thiol-disulfide exchange with glutathione disulfide and by oxyradical-initiated S-thiolation with reduced glutathione.

9823:LACC1
gene id: 9823:LACC1
uniprot id: A0A8D1JQA8
uniprot id: F1RJX9
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

9823:PARD6B
gene id: 9823:PARD6B
uniprot id: A0A4X1UH04
uniprot id: A5GHK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9823:CDK20
gene id: 9823:CDK20
uniprot id: D3K5N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: cilium

9823:SLC25A19
gene id: 9823:SLC25A19
uniprot id: C8C418
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:HSPA4
gene id: 9823:HSPA4
uniprot id: A0A4X1UY89
uniprot id: A0A8D1PLM7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9823:AOX1
gene id: 9823:AOX1
uniprot id: L7TEV7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9823:C3H2orf68
gene id: 9823:C3H2orf68
uniprot id: A0A4X1W7B1
uniprot id: A0A8D0YMP8
names: Similarity
messages: Belongs to the UPF0561 family.

9823:KIF11
gene id: 9823:KIF11
uniprot id: A0A8D1CLX4
uniprot id: F1SC89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle pole

9823:LOC100514912
gene id: 9823:LOC100514912
uniprot id: A0A4X1TZT2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9823:LTC4S
gene id: 9823:LTC4S
uniprot id: A0A8D1M8I1
uniprot id: I3LEI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:CRHR2
gene id: 9823:CRHR2
uniprot id: B8Q4Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

9823:SNRNP27
gene id: 9823:SNRNP27
uniprot id: A0A8D0UTB5
uniprot id: I3LA25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9823:LOC100512568
gene id: 9823:LOC100512568
uniprot id: A0A8D1XG61
uniprot id: F1RR91
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9823:LOC100510930
gene id: 9823:LOC100510930
uniprot id: A0A480KVX2
uniprot id: A0A8D0MRN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9823:HTR1A
gene id: 9823:HTR1A
uniprot id: A0A4X1UTF5
uniprot id: A0A8D1EDW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
messages: Membrane
messages: dendrite

9823:GEMIN2
gene id: 9823:GEMIN2
uniprot id: A0A4X1SVZ2
uniprot id: A0A8D1L5P9
uniprot id: A0A8W4FAH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

9823:S100A4
gene id: 9823:S100A4
uniprot id: F1SFV7
names: Similarity
messages: Belongs to the S-100 family.

9823:TUSC5
gene id: 9823:TUSC5
uniprot id: A0A8D2ADL4
uniprot id: A8D9X0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:EARS2
gene id: 9823:EARS2
uniprot id: A0A287A262
uniprot id: F1SAB4
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9823:TRIM26
gene id: 9823:TRIM26
uniprot id: O77666
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction.
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs) (PubMed:33086712). Plays also a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA. Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signalings. In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation. Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein. Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (By similarity). Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity). Inhibitis Porcine reproductive and respiratory syndrome virus-2 by catalyzing the 'Lys-48'-linked polyubiquitination of the nucleocapsid protein N (PubMed:35077707).
messages: Interacts with TBK1; this interaction bridges together TBK1 and NEMO in order to activate TBK1. Interacts with INCA1.
messages: Nucleus

9823:RPL11
gene id: 9823:RPL11
uniprot id: Q29205
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11. Interacts with PML. Interacts with MDM2; negatively regulates MDM2-mediated TP53 ubiquitination and degradation. Interacts with NOP53; retains RPL11 into the nucleolus.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Promotes nucleolar location of PML.
messages: Cytoplasm
messages: nucleolus

9823:ATXN7L3
gene id: 9823:ATXN7L3
uniprot id: F1RQY2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.
messages: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

9823:LOC100626564
gene id: 9823:LOC100626564
uniprot id: A0A5G2RCY6
uniprot id: A0A8D1AGG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CASP8
gene id: 9823:CASP8
uniprot id: A0A4X1V6R2
uniprot id: Q56VC3
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:EBF3
gene id: 9823:EBF3
uniprot id: A0A287BLL1
uniprot id: A0A8D1DHG1
uniprot id: F1SDK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9823:TAF9B
gene id: 9823:TAF9B
uniprot id: A0A8D0VW00
uniprot id: I3LFP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9823:PMS2
gene id: 9823:PMS2
uniprot id: A0A8D2C9C9
uniprot id: F1RFM9
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9823:LOC100049687
gene id: 9823:LOC100049687
uniprot id: A5HJZ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ST6GAL2
gene id: 9823:ST6GAL2
uniprot id: A0A480E8L5
uniprot id: A0A4X1VUQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

9823:HINT1
gene id: 9823:HINT1
uniprot id: A0A8D1MK00
uniprot id: F1RKI3
names: Similarity
messages: Belongs to the HINT family.

9823:AKIRIN1
gene id: 9823:AKIRIN1
uniprot id: A0A4X1VV46
uniprot id: B2CZF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9823:NDUFC1
gene id: 9823:NDUFC1
uniprot id: A0A8D1AS36
uniprot id: A1XQS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:ARMT1
gene id: 9823:ARMT1
uniprot id: A0A480QLZ8
uniprot id: A0A4X1VQN2
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9823:HSP90B1
gene id: 9823:HSP90B1
uniprot id: A0A4X1T658
uniprot id: Q29092
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Endoplasmic reticulum lumen
messages: Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9 (By similarity). Interacts with CNPY3; this interaction is disrupted in the presence of ATP. Interacts with several TLRs, including TLR4 and TLR9, but not with TLR3 (By similarity). Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with METTL23 (By similarity). Interacts with IL1B; the interaction facilitates cargo translocation into the ERGIC (By similarity).
messages: Melanosome
messages: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity).
messages: Phosphorylated.
messages: Sarcoplasmic reticulum lumen

9823:KRT1
gene id: 9823:KRT1
uniprot id: A0A8D1ZWI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9823:ELOVL3
gene id: 9823:ELOVL3
uniprot id: A0A8D1TU71
uniprot id: D0G6S7
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9823:SLC40A1
gene id: 9823:SLC40A1
uniprot id: A0A4X1TNP1
uniprot id: A0A8D0RK80
uniprot id: I3LV85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

9823:ZSCAN31
gene id: 9823:ZSCAN31
uniprot id: A0A8D1PY47
uniprot id: I3LQQ7
names: Subcellular Location Annotation
messages: Nucleus

9823:RNASE6
gene id: 9823:RNASE6
uniprot id: P81649
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pancreatic ribonuclease family.
messages: Cytoplasmic granule
messages: Interacts (via N-terminus) with bacterial lipopolysaccharide (LPS).
messages: Kidney.
messages: Lysosome
messages: Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:7764367). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (By similarity). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity). Probably contributes to urinary tract sterility (By similarity). Bactericidal activity is independent of RNase activity (By similarity).
messages: Secreted

9823:SH3BP5
gene id: 9823:SH3BP5
uniprot id: A0A8D1H9B2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9823:SNRPC
gene id: 9823:SNRPC
uniprot id: A0A4X1T4T3
uniprot id: A0A4X1T4T8
uniprot id: A0A8D0KLA8
uniprot id: A0A8D1Y0I3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

9823:AQP5
gene id: 9823:AQP5
uniprot id: A8W649
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity).
messages: Homotetramer. Interacts with TRPV4; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity.

9823:GABBR1
gene id: 9823:GABBR1
uniprot id: A0A4X1VL73
uniprot id: F1RYH7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LCK
gene id: 9823:LCK
uniprot id: B8XSK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9823:FSCN1
gene id: 9823:FSCN1
uniprot id: A0A4X1TSZ4
uniprot id: C0LZL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9823:TBX3
gene id: 9823:TBX3
uniprot id: A0A4X1TM24
uniprot id: A0A8D1BL22
uniprot id: F1RKD4
uniprot id: I3LVI3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:POLR3F
gene id: 9823:POLR3F
uniprot id: A0A8D0MJH3
uniprot id: A0A8D0ML72
uniprot id: F1SBH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9823:RXFP1
gene id: 9823:RXFP1
uniprot id: A0A480EUG1
uniprot id: A0A4X1U430
uniprot id: A0A4X1U4R7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:RNF111
gene id: 9823:RNF111
uniprot id: A0A480VLD1
uniprot id: A0A8D0J3Z3
uniprot id: A0A8D1ASU5
uniprot id: A0A8D1C9T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arkadia family.
messages: PML body

9823:PET100
gene id: 9823:PET100
uniprot id: A1XQS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PET100 family.
messages: Interacts with COX7A2.
messages: Membrane
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial complex IV assembly.

9823:FAM149A
gene id: 9823:FAM149A
uniprot id: A0A8D1I1L0
names: Similarity
messages: Belongs to the FAM149 family.

9823:ATP6AP2
gene id: 9823:ATP6AP2
uniprot id: A0A287AJK1
uniprot id: A0A8D1Y888
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9823:INS
gene id: 9823:INS
uniprot id: P01315
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

9823:PPM1A
gene id: 9823:PPM1A
uniprot id: A0A287AJ48
uniprot id: A0A4X1WD12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9823:SLC34A1
gene id: 9823:SLC34A1
uniprot id: Q3LUR7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9823:TSEN2
gene id: 9823:TSEN2
uniprot id: I3LE08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9823:SLC35D1
gene id: 9823:SLC35D1
uniprot id: A0A4X1U6K1
names: Subcellular Location Annotation
messages: Membrane

9823:PAIP2B
gene id: 9823:PAIP2B
uniprot id: A0A4X1W8Q1
uniprot id: A0A8W4FA45
names: Similarity
messages: Belongs to the PAIP2 family.

9823:CPT1A
gene id: 9823:CPT1A
uniprot id: A0A8D1A2C9
uniprot id: Q95JG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:KCNJ15
gene id: 9823:KCNJ15
uniprot id: A0A4X1TQF6
uniprot id: F1SGV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9823:ETV4
gene id: 9823:ETV4
uniprot id: A0A480JQF4
uniprot id: A0A480XKI0
uniprot id: A0A4X1TNR5
uniprot id: A0A8D1ZUH6
uniprot id: F1S1H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:GORASP1
gene id: 9823:GORASP1
uniprot id: A0A4X1TUQ3
names: Similarity
messages: Belongs to the GORASP family.

9823:MRPL2
gene id: 9823:MRPL2
uniprot id: A0A287A143
uniprot id: A0A8D0ZZU0
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9823:TXNIP
gene id: 9823:TXNIP
uniprot id: A0A480K2Q0
uniprot id: Q2HY40
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arrestin family.
messages: Cytoplasm
messages: Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (By similarity). Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4 (By similarity).
messages: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth (By similarity).
messages: Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.

9823:HARBI1
gene id: 9823:HARBI1
uniprot id: A0A8D0NCE0
uniprot id: F1SIA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9823:PTTG1
gene id: 9823:PTTG1
uniprot id: A0A480ZWQ5
uniprot id: A0A8D1FFN5
uniprot id: F1RR55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9823:TRAPPC3
gene id: 9823:TRAPPC3
uniprot id: A0A4X1VS55
uniprot id: A0A8D0LMU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9823:SFXN4
gene id: 9823:SFXN4
uniprot id: A0A286ZKL2
uniprot id: A0A4X1SX31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9823:STEAP2
gene id: 9823:STEAP2
uniprot id: A0A8D1IA15
uniprot id: F1S336
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9823:SMIM19
gene id: 9823:SMIM19
uniprot id: A0A287B4P4
uniprot id: A0A4X1U937
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9823:PTAR1
gene id: 9823:PTAR1
uniprot id: A0A8D2CAT0
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9823:RPS25
gene id: 9823:RPS25
uniprot id: A0A4X1SLJ1
uniprot id: A0A8D0N701
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the small ribosomal subunit.

9823:POP7
gene id: 9823:POP7
uniprot id: A0A4X1UCQ2
uniprot id: F1RMX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9823:CDX1
gene id: 9823:CDX1
uniprot id: A0A480JPE6
uniprot id: A0A8D0T324
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9823:MTFR2
gene id: 9823:MTFR2
uniprot id: A0A8D1Y5F9
uniprot id: F1S3R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9823:LOC100624207
gene id: 9823:LOC100624207
uniprot id: A0A8D0IIJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ADAMTS1
gene id: 9823:ADAMTS1
uniprot id: Q2N1I7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:ZPR1
gene id: 9823:ZPR1
uniprot id: A0A4X1T2A9
uniprot id: A0A8D0XSF7
names: Similarity
messages: Belongs to the ZPR1 family.

9823:AP4E1
gene id: 9823:AP4E1
uniprot id: A0A8D0QZ48
uniprot id: A0A8D1QJQ9
names: Function
names: Similarity
names: Subunit
messages: Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins, a medium adaptin and a small adaptin.
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

9823:LOC100516302
gene id: 9823:LOC100516302
uniprot id: A0A4X1V144
uniprot id: I3LTB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9823:CCNG1
gene id: 9823:CCNG1
uniprot id: A0A480PKJ0
uniprot id: Q52QT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
messages: Nucleus

9823:NR1H3
gene id: 9823:NR1H3
uniprot id: A0A287B056
uniprot id: A0A480WYK6
uniprot id: A0A4X1VT52
uniprot id: Q4TU03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9823:LOC100512650
gene id: 9823:LOC100512650
uniprot id: A0A287BC49
uniprot id: A0A4X1SNB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:DPRX
gene id: 9823:DPRX
uniprot id: A0A480EEG2
names: Subcellular Location Annotation
messages: Nucleus

9823:CCL26
gene id: 9823:CCL26
uniprot id: A0A8D1YQR5
uniprot id: Q0N2S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:ARPC1B
gene id: 9823:ARPC1B
uniprot id: A0A4X1U5P2
uniprot id: B5APU6
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

9823:ENO2
gene id: 9823:ENO2
uniprot id: A0A8D2BGJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9823:RUNX1
gene id: 9823:RUNX1
uniprot id: A0A4X1TP86
uniprot id: F8SIP5
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9823:PGLYRP2
gene id: 9823:PGLYRP2
uniprot id: Q866Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.
messages: Membrane
messages: Secreted

9823:RNASET2
gene id: 9823:RNASET2
uniprot id: A0A5G2QZM3
uniprot id: A0A8D1SJR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Lysosome lumen

9823:TNFSF8
gene id: 9823:TNFSF8
uniprot id: A0A4X1V0N6
uniprot id: A0A8D0X6I3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:ZUFSP
gene id: 9823:ZUFSP
uniprot id: A0A4X1TE28
uniprot id: A0A8D1WS53
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9823:BRCC3
gene id: 9823:BRCC3
uniprot id: A0A480V5W3
uniprot id: A0A4X1T8A2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9823:RPL38
gene id: 9823:RPL38
uniprot id: A0A4X1VLH7
uniprot id: A0A8D0KER0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9823:ENO4
gene id: 9823:ENO4
uniprot id: A0A481BB88
uniprot id: A0A4X1SZI5
uniprot id: F1S4S3
names: Similarity
messages: Belongs to the enolase family.

9823:HNRNPA3
gene id: 9823:HNRNPA3
uniprot id: A0A480W0D4
uniprot id: A0A4X1UJV5
uniprot id: A0A8X9AEX1
names: Subcellular Location Annotation
messages: Nucleus

9823:ITGB8
gene id: 9823:ITGB8
uniprot id: A4GUC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

9823:ZSCAN12
gene id: 9823:ZSCAN12
uniprot id: A0A480S2P2
uniprot id: A0A8D1C485
names: Subcellular Location Annotation
messages: Nucleus

9823:ARF4
gene id: 9823:ARF4
uniprot id: A0A8D0M5A1
uniprot id: Q56P20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9823:SYT1
gene id: 9823:SYT1
uniprot id: A0A480P6K7
uniprot id: A0A8D1HAI0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

9823:SDHD
gene id: 9823:SDHD
uniprot id: A0A8D1GMP5
uniprot id: A5GZW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9823:CLEC12A
gene id: 9823:CLEC12A
uniprot id: A0A076KXE7
uniprot id: A0A8D0YHY6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:ACO1
gene id: 9823:ACO1
uniprot id: A0A287BQT2
uniprot id: A0A4X1UMC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Cytoplasm

9823:NEFM
gene id: 9823:NEFM
uniprot id: A0A8D1UI82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon

9823:EZH1
gene id: 9823:EZH1
uniprot id: A0A8D0Y904
names: Subcellular Location Annotation
messages: Nucleus

9823:CENPU
gene id: 9823:CENPU
uniprot id: A0A4X1VRS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-U/AME1 family.
messages: Nucleus

9823:CCND3
gene id: 9823:CCND3
uniprot id: Q007T4
names: Similarity
messages: Belongs to the cyclin family.

9823:SKA1
gene id: 9823:SKA1
uniprot id: A0A4X1UKI5
uniprot id: F1RPP2
names: Similarity
messages: Belongs to the SKA1 family.

9823:C4H8orf37
gene id: 9823:C4H8orf37
uniprot id: A0A287BAN6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9823:PFN2
gene id: 9823:PFN2
uniprot id: A0A4X1SZN9
names: Similarity
messages: Belongs to the profilin family.

9823:MON1B
gene id: 9823:MON1B
uniprot id: A0A480JRT2
uniprot id: A0A8D1XDE4
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9823:SH3GL1
gene id: 9823:SH3GL1
uniprot id: A0A4X1VR96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9823:MED8
gene id: 9823:MED8
uniprot id: A0A287AM03
uniprot id: A0A4X1W7X7
uniprot id: A0A5G2QHV8
uniprot id: A0A8D0SXV6
uniprot id: A0A8D1FXJ4
uniprot id: A0A8D1MJH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:METTL2A
gene id: 9823:METTL2A
uniprot id: A0A4X1T701
uniprot id: A0A5G2RBP0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9823:ZFPM2
gene id: 9823:ZFPM2
uniprot id: D3K5N4
names: Subcellular Location Annotation
messages: Nucleus

9823:TCIRG1
gene id: 9823:TCIRG1
uniprot id: A0A8D1D0A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9823:GPR156
gene id: 9823:GPR156
uniprot id: A0A8D1AXN8
uniprot id: F1SPD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9823:SLC19A2
gene id: 9823:SLC19A2
uniprot id: B7U654
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9823:OTUB1
gene id: 9823:OTUB1
uniprot id: A0A8D1UUM7
uniprot id: C5H0C6
names: Similarity
messages: Belongs to the peptidase C65 family.

9823:KRR1
gene id: 9823:KRR1
uniprot id: A0A480Y0Q0
uniprot id: A0A8D1Y528
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9823:PDCD4
gene id: 9823:PDCD4
uniprot id: A0A4X1TF35
uniprot id: A0A4X1TG29
names: Similarity
messages: Belongs to the PDCD4 family.

9823:DGKE
gene id: 9823:DGKE
uniprot id: A0A8D0NLU7
uniprot id: D0G6S2
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9823:PRKAR1A
gene id: 9823:PRKAR1A
uniprot id: A0A4X1SQ46
uniprot id: A0A4X1SRN7
uniprot id: P07802
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
messages: Membrane
messages: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
messages: The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKACA and PRKACB (By similarity). PRKAR1A also interacts with RFC2; the complex may be involved in cell survival. Interacts with AKAP4. Interacts with RARA; the interaction occurs in the presence of cAMP or FSH and regulates RARA transcriptional activity. Interacts with the phosphorylated form of PJA2. Interacts with CBFA2T3. Interacts with PRKX; regulates this cAMP-dependent protein kinase (By similarity). Interacts with smAKAP; this interaction may target PRKAR1A to the plasma membrane. Interacts with AICDA (By similarity).
messages: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.

9823:INPP4A
gene id: 9823:INPP4A
uniprot id: B8R0Y5
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9823:NME2
gene id: 9823:NME2
uniprot id: Q2EN76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6) (By similarity). Interacts with CAPN8 (By similarity). Interacts with AKAP13 (By similarity). Interacts with ITGB1BP1 (via C-terminal domain region) (By similarity). Interacts with BCL2L10 (By similarity).
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not. Exhibits histidine protein kinase activity (By similarity).
messages: Nucleus
messages: lamellipodium
messages: ruffle

9823:FAM46D
gene id: 9823:FAM46D
uniprot id: A0A4X1W2X7
uniprot id: F1S1S5
names: Similarity
messages: Belongs to the TENT family.

9823:CD164
gene id: 9823:CD164
uniprot id: A0A4X1VE80
uniprot id: A0A8D1SLJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9823:AGTR1
gene id: 9823:AGTR1
uniprot id: P30555
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: C-terminal Ser or Thr residues may be phosphorylated.
messages: Cell membrane
messages: Interacts with MAS1 (By similarity). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:8491254). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (By similarity).

9823:TOMM40L
gene id: 9823:TOMM40L
uniprot id: A0A8D0HVB4
uniprot id: A0A8D1IS56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:NSUN4
gene id: 9823:NSUN4
uniprot id: A0A8D1JPK7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9823:EMP1
gene id: 9823:EMP1
uniprot id: A6N1V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9823:FGF16
gene id: 9823:FGF16
uniprot id: A0A4X1SGY7
uniprot id: I3LR27
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:LOC100737570
gene id: 9823:LOC100737570
uniprot id: A0A4X1U1W4
uniprot id: A0A5G2QL45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LACTB2
gene id: 9823:LACTB2
uniprot id: A0A8D1ND05
uniprot id: F1RU12
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

9823:PCYOX1L
gene id: 9823:PCYOX1L
uniprot id: A0A480VKE5
uniprot id: A0A8D1WVR6
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9823:KRT8
gene id: 9823:KRT8
uniprot id: A0A4X1WBI1
uniprot id: A0A8D1AD15
names: Similarity
messages: Belongs to the intermediate filament family.

9823:PLPBP
gene id: 9823:PLPBP
uniprot id: A0A8D1CGB9
uniprot id: F1RX84
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

9823:MEOX1
gene id: 9823:MEOX1
uniprot id: A0A5G2RBV7
uniprot id: A0A8D1LTQ2
uniprot id: A0A8D2CGI1
uniprot id: F1S1H4
names: Subcellular Location Annotation
messages: Nucleus

9823:SNCA
gene id: 9823:SNCA
uniprot id: Q3I5G7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
messages: Belongs to the synuclein family.
messages: Cytoplasm
messages: Membrane
messages: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).
messages: Nucleus
messages: Phosphorylated, predominantly on serine residues.
messages: Secreted
messages: Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (By similarity). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (By similarity).
messages: Synapse
messages: Ubiquitinated. The predominant conjugate is the diubiquitinated form.
messages: axon

9823:NTF4
gene id: 9823:NTF4
uniprot id: A0A4X1VZW4
uniprot id: F1RIN3
names: Similarity
messages: Belongs to the NGF-beta family.

9823:KIAA1024
gene id: 9823:KIAA1024
uniprot id: A0A8D1L4W4
uniprot id: A0A8D1QBN5
names: Similarity
messages: Belongs to the MINAR family.

9823:HAX1
gene id: 9823:HAX1
uniprot id: A0A481BZY7
uniprot id: A0A8D0XZN0
names: Function
names: Similarity
messages: Belongs to the HAX1 family.
messages: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

9823:CACNG7
gene id: 9823:CACNG7
uniprot id: A0A8D0W7Q0
uniprot id: F2Z4Y2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

9823:INPP1
gene id: 9823:INPP1
uniprot id: A0A4X1TID0
uniprot id: F1SN51
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9823:PAPOLG
gene id: 9823:PAPOLG
uniprot id: A0A4X1WBM2
uniprot id: A0A8D0U3G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

9823:NDUFA6
gene id: 9823:NDUFA6
uniprot id: A0A480VKQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:TRAF5
gene id: 9823:TRAF5
uniprot id: K7GN38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9823:TAC1
gene id: 9823:TAC1
uniprot id: A0A4X1TPS0
uniprot id: A0A4X1TSN8
uniprot id: A0A4X1TSP2
uniprot id: A0A8D0K2W3
uniprot id: A0A8D0WK79
uniprot id: A0A8D1LKF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9823:THRB
gene id: 9823:THRB
uniprot id: A0A286ZWA8
uniprot id: A0A287A833
uniprot id: A0A4X1UK31
uniprot id: A0A4X1ULP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9823:TADA1
gene id: 9823:TADA1
uniprot id: A0A8D0NPK8
uniprot id: F1S248
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

9823:BHMT
gene id: 9823:BHMT
uniprot id: A0A8D2CIG9
uniprot id: E7D6R2
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9823:FAM198B
gene id: 9823:FAM198B
uniprot id: A0A4X1U4G4
uniprot id: A0A8D0IT39
names: Similarity
messages: Belongs to the GASK family.

9823:IFN-ALPHA-15
gene id: 9823:IFN-ALPHA-15
uniprot id: C8CKA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:SELENOP
gene id: 9823:SELENOP
uniprot id: A1E951
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein P family.
messages: Secreted

9823:PADI1
gene id: 9823:PADI1
uniprot id: A0A8D1CS67
uniprot id: K7GNB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9823:LOC100523745
gene id: 9823:LOC100523745
uniprot id: A0A8D1WAT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9823:TELO2
gene id: 9823:TELO2
uniprot id: A0A287AD90
uniprot id: A0A8D1LAA2
uniprot id: A0A8D1WKU2
names: Similarity
messages: Belongs to the TEL2 family.

9823:UBE2T
gene id: 9823:UBE2T
uniprot id: A0A8D0LVP3
uniprot id: F1S5B2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:CREB1
gene id: 9823:CREB1
uniprot id: Q5I240
names: Subcellular Location Annotation
messages: Nucleus

9823:CTGF
gene id: 9823:CTGF
uniprot id: O97765
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:PERP
gene id: 9823:PERP
uniprot id: A0A4X1VKL0
uniprot id: A0A8D0MJG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9823:LOC100515171
gene id: 9823:LOC100515171
uniprot id: A0A286ZLY4
uniprot id: A0A287AUP2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9823:RAP2C
gene id: 9823:RAP2C
uniprot id: A0A8D0WUH2
uniprot id: I3LH60
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9823:LOC106504912
gene id: 9823:LOC106504912
uniprot id: A0A4X1TVF5
uniprot id: A0A8W4FK69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NSF
gene id: 9823:NSF
uniprot id: A0A287AYL9
uniprot id: A0A4X1TAC2
uniprot id: A0A4X1TE64
uniprot id: A0A8D1JA75
uniprot id: A0A8D1VDY7
uniprot id: F1RRS3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

9823:TSPO
gene id: 9823:TSPO
uniprot id: Q6UN27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TspO/BZRP family.
messages: Interacts with TSPOAP1. Interacts with MOST-1. May interact with STAR.
messages: Mitochondrion membrane
messages: Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (By similarity).
messages: Ubiquitous.

9823:SPP1
gene id: 9823:SPP1
uniprot id: D0G7G0
uniprot id: P14287
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
messages: Belongs to the osteopontin family.
messages: Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif (By similarity). The phosphorylated form inhibits hydroxyapatite crystallization. Dephosphorylation via a mechanism involving ALPL/TNAP promotes hydroxyapatite crystallization (By similarity).
messages: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers, increasing its collagen binding properties.
messages: Ligand for integrin alpha-V/beta-3.
messages: Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
messages: O-glycosylated.
messages: Secreted

9823:FGF5
gene id: 9823:FGF5
uniprot id: A0A287AAE4
uniprot id: A0A4X1T0C6
uniprot id: A0A8W4FEU6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:SCRN2
gene id: 9823:SCRN2
uniprot id: F1RWI8
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9823:DDIT4L
gene id: 9823:DDIT4L
uniprot id: A0A4X1UI95
uniprot id: I3LT71
names: Similarity
messages: Belongs to the DDIT4 family.

9823:CYP2E1
gene id: 9823:CYP2E1
uniprot id: P79383
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9823:DNAJC24
gene id: 9823:DNAJC24
uniprot id: A0A8D1B6R3
uniprot id: I3L880
names: Similarity
messages: Belongs to the DPH4 family.

9823:NECAP2
gene id: 9823:NECAP2
uniprot id: A0A287B045
uniprot id: A0A8D2BCV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9823:SLC12A1
gene id: 9823:SLC12A1
uniprot id: A0A287BI72
uniprot id: A0A8D0UAD2
uniprot id: F1SN65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9823:HMGN4
gene id: 9823:HMGN4
uniprot id: A0A4X1VFC9
uniprot id: I3LKV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9823:CATSPERE
gene id: 9823:CATSPERE
uniprot id: A0A4X1T3V8
names: Similarity
messages: Belongs to the CATSPERD family.

9823:DXO
gene id: 9823:DXO
uniprot id: A0A4X1VBG9
uniprot id: A5PEZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

9823:ZC2HC1C
gene id: 9823:ZC2HC1C
uniprot id: A0A4X1T926
uniprot id: F1S2Q5
names: Similarity
messages: Belongs to the ZC2HC1 family.

9823:LIX1
gene id: 9823:LIX1
uniprot id: A0A8D0TW15
uniprot id: A0A8D1QGR1
names: Similarity
messages: Belongs to the LIX1 family.

9823:AQP7
gene id: 9823:AQP7
uniprot id: A0A4X1URD6
uniprot id: A0A8D1E4G2
uniprot id: A9Y007
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:LOC100739859
gene id: 9823:LOC100739859
uniprot id: A0A8D0LEC0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SLC7A9
gene id: 9823:SLC7A9
uniprot id: A8HG47
names: Subcellular Location Annotation
messages: Membrane

9823:GKN1
gene id: 9823:GKN1
uniprot id: Q8HYA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the gastrokine family.
messages: Cytoplasmic granule
messages: Golgi apparatus
messages: Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
messages: Highly expressed specifically in surface cells of the antrum mucosa from where it is secreted.
messages: Secreted

9823:CSTF3
gene id: 9823:CSTF3
uniprot id: A0A8D1MKV3
uniprot id: A0A8D1PS07
names: Subcellular Location Annotation
messages: Nucleus

9823:FOXN3
gene id: 9823:FOXN3
uniprot id: Q33BP8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints) (By similarity).
messages: Interacts through its C-terminus with the C-terminus of SNW1/SKIP.
messages: Nucleus

9823:TACR2
gene id: 9823:TACR2
uniprot id: A0A4X1TFX5
uniprot id: A0A8D0V2Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:TM2D2
gene id: 9823:TM2D2
uniprot id: A0A8D0T4V4
uniprot id: I3LTJ8
names: Subcellular Location Annotation
messages: Membrane

9823:PTGR2
gene id: 9823:PTGR2
uniprot id: A0A4X1TM83
uniprot id: A0A8D0LY49
uniprot id: F1S3H7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9823:SQLE
gene id: 9823:SQLE
uniprot id: A0A8D1HQ11
uniprot id: A7L861
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9823:CASP9
gene id: 9823:CASP9
uniprot id: A0A4X1W1Y9
uniprot id: A0A4X1W839
uniprot id: F1SUV9
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:METTL15
gene id: 9823:METTL15
uniprot id: A0A8D2C5A4
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9823:LOC100626583
gene id: 9823:LOC100626583
uniprot id: A0A287AEQ9
uniprot id: A0A4X1U676
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9823:PARP11
gene id: 9823:PARP11
uniprot id: A0A286ZV63
uniprot id: A0A4X1UMS3
uniprot id: A0A4X1UQW7
uniprot id: A0A4X1UQZ1
uniprot id: F1SKY8
uniprot id: I3LAD0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9823:CDCA7
gene id: 9823:CDCA7
uniprot id: A0A286ZUB5
uniprot id: A0A287BST9
uniprot id: A0A4X1UPH8
uniprot id: A0A8D1G0M4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:SLC22A6
gene id: 9823:SLC22A6
uniprot id: Q8MK48
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Basal cell membrane
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Glycosylated. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane.
messages: Involved in the renal transport of a variety of drugs with well-known nephrotoxic potential, therefore may play a role in the etiology of the drug-associated nephrotoxicity (By similarity). Uptakes the diagnostic agent PAH/para-aminohippurate and clinically used drugs (PubMed:12628298). Mediates the bidirectional transport of PAH/para-aminohippurate (By similarity).
messages: Multiple cysteine residues are necessary for proper targeting to the plasma membrane.
messages: Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion (By similarity). Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP (By similarity). Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain. May transport glutamate. Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body. Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate. Xenobiotics include the mycotoxin ochratoxin (OTA). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier (By similarity).

9823:PRKAG1
gene id: 9823:PRKAG1
uniprot id: Q09138
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity).
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity).
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.
messages: Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK.
messages: The 4 CBS domains mediate binding to nucleotides. Of the 4 potential nucleotide-binding sites, 3 are occupied, designated as sites 1, 3, and 4 based on the CBS modules that provide the acidic residue for coordination with the 2'- and 3'-hydroxyl groups of the ribose of AMP. Of these, site 4 appears to be a structural site that retains a tightly held AMP molecule (AMP 3). The 2 remaining sites, 1 and 3, can bind either AMP, ADP or ATP. Site 1 (AMP, ADP or ATP 1) is the high-affinity binding site and likely accommodates AMP or ADP. Site 3 (AMP, ADP or ATP 2) is the weakest nucleotide-binding site on the gamma subunit, yet it is exquisitely sensitive to changes in nucleotide levels and this allows AMPK to respond rapidly to changes in cellular energy status. Site 3 is likely to be responsible for protection of a conserved threonine in the activation loop of the alpha catalytic subunit through conformational changes induced by binding of AMP or ADP.
messages: The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1 (By similarity).

9823:TPST1
gene id: 9823:TPST1
uniprot id: A0A4X1SY72
uniprot id: A0A8D1DJM7
uniprot id: F8S1I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9823:LOC100510917
gene id: 9823:LOC100510917
uniprot id: A0A4X1TGN8
uniprot id: A0A8D1KF14
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9823:DR1
gene id: 9823:DR1
uniprot id: A0A4X1U1Q8
uniprot id: A0A8D1V057
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9823:FAM219A
gene id: 9823:FAM219A
uniprot id: A0A8D1GDB7
names: Similarity
messages: Belongs to the FAM219 family.

9823:WIF1
gene id: 9823:WIF1
uniprot id: A0A8D1B219
uniprot id: K7GQ27
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:FMNL1
gene id: 9823:FMNL1
uniprot id: A0A480LCB3
uniprot id: A0A480T1G5
uniprot id: A0A8D0XC04
uniprot id: A0A8D1CCX1
names: Similarity
messages: Belongs to the formin homology family.

9823:PSP-II
gene id: 9823:PSP-II
uniprot id: P35496
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the spermadhesin family.
messages: Monomer or heterodimer with PSP-I (depending on the type of glycosylation of PSP-I).
messages: Secreted
messages: Seminal plasma or sperm.

9823:FAM136A
gene id: 9823:FAM136A
uniprot id: A0A4X1W9G6
uniprot id: F1SLD2
names: Similarity
messages: Belongs to the FAM136 family.

9823:LOC100152722
gene id: 9823:LOC100152722
uniprot id: A0A8D2C8U8
uniprot id: F1RK64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9823:DLGAP5
gene id: 9823:DLGAP5
uniprot id: A0A8D1CPG8
names: Similarity
messages: Belongs to the SAPAP family.

9823:IDH3B
gene id: 9823:IDH3B
uniprot id: A0A8D1ZWC4
uniprot id: Q1G1K7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9823:ABL2
gene id: 9823:ABL2
uniprot id: A0A4X1U5Y5
uniprot id: A0A4X1U822
uniprot id: A0A4X1U827
uniprot id: A0A4X1U8J1
uniprot id: A0A4X1U8M4
uniprot id: A0A8D0JR66
uniprot id: A0A8D1ES88
uniprot id: A0A8D1EUQ4
uniprot id: A0A8D1NF82
uniprot id: A0A8D1NM18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:PCK2
gene id: 9823:PCK2
uniprot id: A0A4X1SLW9
uniprot id: C5I4T6
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9823:NTS
gene id: 9823:NTS
uniprot id: A0A8D1E798
uniprot id: F1SPX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9823:HOGA1
gene id: 9823:HOGA1
uniprot id: A0A4X1UAM4
uniprot id: A0A8D0TM74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9823:GTF2F2
gene id: 9823:GTF2F2
uniprot id: A0A4X1SER4
uniprot id: A0A8D0Q294
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9823:RLN3
gene id: 9823:RLN3
uniprot id: Q8HY17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: May play a role in neuropeptide signaling processes. Ligand for LGR7, RXFP3 and RXFP4 (By similarity).
messages: Secreted

9823:SLC28A2
gene id: 9823:SLC28A2
uniprot id: A0A4X1VEK8
uniprot id: A0A8D0M6S2
uniprot id: A0A8D1ZEL5
uniprot id: F1SN44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9823:IL18R1
gene id: 9823:IL18R1
uniprot id: Q8HXQ6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9823:ETS1
gene id: 9823:ETS1
uniprot id: C5IWV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9823:RAD52
gene id: 9823:RAD52
uniprot id: A0A480VSL0
uniprot id: A0A8D1G7I6
uniprot id: B0M1M7
names: Similarity
messages: Belongs to the RAD52 family.

9823:CHMP4C
gene id: 9823:CHMP4C
uniprot id: A0A4X1TDZ8
uniprot id: I3LG19
names: Similarity
messages: Belongs to the SNF7 family.

9823:TFPI
gene id: 9823:TFPI
uniprot id: A0A8D2A5Z0
uniprot id: B5ST96
names: Subcellular Location Annotation
messages: Secreted

9823:ITIH1
gene id: 9823:ITIH1
uniprot id: Q29052
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITIH family.
messages: Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
messages: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin. Interacts with TNFAIP6 (via Link and CUB domains).
messages: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
messages: Secreted
messages: The S-linked glycan is composed of two 6-carbon sugars, possibly Glc or Gal.

9823:BMPR2
gene id: 9823:BMPR2
uniprot id: A0A4X1V8C6
uniprot id: F1SI16
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9823:SLC25A31
gene id: 9823:SLC25A31
uniprot id: F1RRA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9823:ZPBP
gene id: 9823:ZPBP
uniprot id: Q29108
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Expressed in testis. Detected in sperm cells.
messages: N-glycosylated.
messages: Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization.
messages: Secreted
messages: acrosome
messages: acrosome membrane

9823:GAL3ST1
gene id: 9823:GAL3ST1
uniprot id: A0A287BRU9
uniprot id: A0A4X1VA83
uniprot id: A0A8D1BYN5
uniprot id: F1RPE6
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9823:MINDY3
gene id: 9823:MINDY3
uniprot id: A0A4X1U705
uniprot id: F1RW87
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9823:TMED10
gene id: 9823:TMED10
uniprot id: A0A286ZV95
uniprot id: A0A8D0K0A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:SLC24A4
gene id: 9823:SLC24A4
uniprot id: A0A8D2BLJ6
uniprot id: F1SD72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9823:TRPC4
gene id: 9823:TRPC4
uniprot id: C0JJ16
names: Subcellular Location Annotation
messages: Membrane

9823:LDAH
gene id: 9823:LDAH
uniprot id: A0A8D1RXF6
uniprot id: I3L9Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

9823:GLG1
gene id: 9823:GLG1
uniprot id: A0A8D2CFE8
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

9823:REEP4
gene id: 9823:REEP4
uniprot id: A0A8D0LS54
uniprot id: F1RMB6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:IRGC
gene id: 9823:IRGC
uniprot id: D7EZJ4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9823:DDX52
gene id: 9823:DDX52
uniprot id: A0A8D1X1X7
uniprot id: I3LJA0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

9823:TIMM21
gene id: 9823:TIMM21
uniprot id: A0A287BDA0
uniprot id: A0A4X1U114
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9823:HTR4
gene id: 9823:HTR4
uniprot id: Q6Q253
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

9823:NDUFB6
gene id: 9823:NDUFB6
uniprot id: A0A4X1UIV8
uniprot id: Q2EN80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:MRPL52
gene id: 9823:MRPL52
uniprot id: A0A8D1AHF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

9823:ADD3
gene id: 9823:ADD3
uniprot id: A0A4X1TEQ8
uniprot id: A0A4X1TIC1
uniprot id: A0A8D0XJC4
uniprot id: A0A8D1HCF3
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9823:SCO2
gene id: 9823:SCO2
uniprot id: A0A287AQS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCO1/2 family.
messages: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
messages: Homodimer.
messages: Mitochondrion inner membrane

9823:ARFGEF2
gene id: 9823:ARFGEF2
uniprot id: A0A5G2QXW0
uniprot id: A0A8D1RFB5
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9823:FUT11
gene id: 9823:FUT11
uniprot id: A0A287BIT3
uniprot id: A0A8D1H7C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9823:C4H8orf46
gene id: 9823:C4H8orf46
uniprot id: A0A480DGF7
uniprot id: A0A4X1UZ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vexin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus

9823:PRTFDC1
gene id: 9823:PRTFDC1
uniprot id: A0A8D0XQ92
uniprot id: A0A8W4FGJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9823:CNN3
gene id: 9823:CNN3
uniprot id: A0A4X1TUU1
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9823:ACTB
gene id: 9823:ACTB
uniprot id: Q6QAQ1
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (PubMed:36071160, PubMed:25814576, PubMed:29420470, PubMed:33734450).
messages: Belongs to the actin family.
messages: ISGylated.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-73 by SETD3 (By similarity). Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (By similarity).
messages: Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.
messages: N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP.
messages: Nucleus
messages: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM (By similarity). Interacts with TBC1D21. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes. Interacts with FAM107A (By similarity). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (PubMed:25814576, PubMed:36071160, PubMed:29420470, PubMed:33734450). The filament contains 8 copies of ACTR1A and 1 ACTB (PubMed:25814576).
messages: cytoskeleton

9823:POPDC2
gene id: 9823:POPDC2
uniprot id: B8Q0B3
names: Similarity
messages: Belongs to the popeye family.

9823:CCL24
gene id: 9823:CCL24
uniprot id: A0A8D1PHB6
uniprot id: Q0N2S9
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9823:LOC100623990
gene id: 9823:LOC100623990
uniprot id: A0A8D1CUR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NUP133
gene id: 9823:NUP133
uniprot id: A0A4X1U7F6
uniprot id: A0A8D0LKS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

9823:SLC37A3
gene id: 9823:SLC37A3
uniprot id: A0A480P6F2
uniprot id: A0A8D0VT39
names: Subcellular Location Annotation
messages: Membrane

9823:NFATC1
gene id: 9823:NFATC1
uniprot id: O77638
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers (By similarity). Interacts with HOMER2 and HOMER3; this interaction may compete with calcineurin/PPP3CA-binding and hence prevent NFATC1 dephosphorylation and activation (By similarity). Interacts with TLE6/GRG6 (By similarity).
messages: Nucleus
messages: Phosphorylated by NFATC-kinase and GSK3B; phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1 (By similarity).
messages: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.
messages: Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
messages: The N-terminal transactivation domain (TAD-A) binds to and is activated by Cbp/p300. The dephosphorylated form contains two unmasked nuclear localization signals (NLS), which allow translocation of the protein to the nucleus (By similarity).

9823:LOC100522130
gene id: 9823:LOC100522130
uniprot id: A0A480XVY9
uniprot id: A0A4X1VWX3
names: Similarity
messages: Belongs to the FAH family.

9823:TMPRSS4
gene id: 9823:TMPRSS4
uniprot id: A0A4X1STB8
uniprot id: A0A8D0QWC5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100525388
gene id: 9823:LOC100525388
uniprot id: A0A4X1SNJ4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PTPRK
gene id: 9823:PTPRK
uniprot id: A0A287AEP8
uniprot id: A0A287B937
uniprot id: A0A480JYK3
uniprot id: A0A480NFN1
uniprot id: A0A8D0XAV0
uniprot id: A0A8D1PZ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9823:MAP2K4
gene id: 9823:MAP2K4
uniprot id: A0A8D0NMI2
uniprot id: A0A8D1CWD0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:PALM
gene id: 9823:PALM
uniprot id: Q2MJV8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apicolateral cell membrane
messages: Basolateral cell membrane
messages: Belongs to the paralemmin family.
messages: Cell membrane
messages: Interacts with dopamine receptor DRD3.
messages: Involved in plasma membrane dynamics and cell process formation. Necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner (By similarity).
messages: Phosphorylated.
messages: axon
messages: dendrite
messages: dendritic spine
messages: filopodium membrane

9823:TAP2
gene id: 9823:TAP2
uniprot id: A0A8D1TYN8
uniprot id: A5D9J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

9823:GNGT1
gene id: 9823:GNGT1
uniprot id: A0A4X1U0G3
uniprot id: A0A8D1C771
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9823:AHCYL2
gene id: 9823:AHCYL2
uniprot id: A0A287A100
uniprot id: A0A4X1VYW3
uniprot id: A0A4X1W051
uniprot id: A0A8D1H5S6
uniprot id: F1SMQ4
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

9823:CYP2C49
gene id: 9823:CYP2C49
uniprot id: Q8SQ65
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:TM9SF1
gene id: 9823:TM9SF1
uniprot id: A0A4X1SP11
uniprot id: A0A8D1ZH85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9823:GRB2
gene id: 9823:GRB2
uniprot id: A0A8D1NZZ8
uniprot id: B6E241
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9823:EIF2B1
gene id: 9823:EIF2B1
uniprot id: A0A286ZJA8
uniprot id: A0A8D1JHP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

9823:PADI4
gene id: 9823:PADI4
uniprot id: A0A8D1QC14
uniprot id: F1SUR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9823:LOC100524576
gene id: 9823:LOC100524576
uniprot id: A0A4X1VDL9
uniprot id: A0A5G2QW67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TRIM45
gene id: 9823:TRIM45
uniprot id: A0A8D1VNM6
uniprot id: K7GLN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9823:LRP3
gene id: 9823:LRP3
uniprot id: A0A8D1JEJ1
uniprot id: A0A8D1P1T5
uniprot id: F1RNW9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DTX4
gene id: 9823:DTX4
uniprot id: A0A287AIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9823:LOC100518239
gene id: 9823:LOC100518239
uniprot id: A0A4X1SWA3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RUVBL2
gene id: 9823:RUVBL2
uniprot id: A0A481C216
uniprot id: A0A4X1VU44
uniprot id: A0A8D1X2F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9823:ARPP19
gene id: 9823:ARPP19
uniprot id: Q712U6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Interacts (when phosphorylated at Ser-62) with PPP2R2D. Interacts with SNCA (By similarity).
messages: Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA (By similarity).
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity).
messages: Ubiquitously expressed.

9823:GH1
gene id: 9823:GH1
uniprot id: F6M7Y8
uniprot id: Q28957
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9823:DSG1
gene id: 9823:DSG1
uniprot id: Q3BDI7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to JUP/plakoglobin (By similarity). Interacts with PKP2 (By similarity).
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
messages: desmosome

9823:DCP1B
gene id: 9823:DCP1B
uniprot id: A0A4X1UEQ7
uniprot id: A0A8D1Y1T4
names: Similarity
messages: Belongs to the DCP1 family.

9823:STATH
gene id: 9823:STATH
uniprot id: D8WUT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Secreted

9823:CCT3
gene id: 9823:CCT3
uniprot id: A0A287AMZ2
uniprot id: A0A8D0VM93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9823:PSMB11
gene id: 9823:PSMB11
uniprot id: A0A4X1V3X5
uniprot id: F1S9C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9823:LOC106504901
gene id: 9823:LOC106504901
uniprot id: A0A8D1A589
uniprot id: F1S9P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MDFIC
gene id: 9823:MDFIC
uniprot id: A0A4X1W5Z4
uniprot id: F1SJC4
names: Similarity
messages: Belongs to the MDFI family.

9823:NEIL1
gene id: 9823:NEIL1
uniprot id: A0A4X1TT87
uniprot id: A0A8D1CQV2
names: Similarity
messages: Belongs to the FPG family.

9823:ATP1B4
gene id: 9823:ATP1B4
uniprot id: A0A481AY03
uniprot id: Q9BDK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with a SMAD7-transcriptional complex. Interacts with SNW1 and TOR1AIP1. Does not associate with known Na,K-ATPase alpha-subunits (By similarity).
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Expressed in skeletal muscle (at protein level). Expressed during postnatal development in skeletal muscle and heart.
messages: May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).
messages: Membrane
messages: Nucleus inner membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9823:SLC2A4
gene id: 9823:SLC2A4
uniprot id: B2LWF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9823:SEPT2
gene id: 9823:SEPT2
uniprot id: A0A8D1RQ57
uniprot id: F1SIP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

9823:LOC100514038
gene id: 9823:LOC100514038
uniprot id: A0A4X1UD02
uniprot id: F1RMY6
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9823:RPS3
gene id: 9823:RPS3
uniprot id: Q0Z8U2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the 40S small ribosomal subunit. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with HNRPD. Interacts with PRMT1; the interaction methylates RPS3. Interacts with SUMO1; the interaction sumoylates RPS3. Interacts with UBC9. Interacts with CDK1; the interaction phosphorylates RPS3. Interacts with PRKCD; the interaction phosphorylates RPS3. Interacts with PKB/AKT; the interaction phosphorylates RPS3. Interacts with E2F1; the interaction occurs in the absence of nerve growth factor and increases transcription of pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with the base excision repair proteins APEX1 and OGG1; interaction with OGG1 increases OGG1 N-glycosylase activity. Interacts with UNG; the interaction increases the uracil excision activity of UNG1. Interacts with HSP90; the interaction prevents the ubiquitination and proteasome-dependent degradation of RPS3 and is suppressed by increased ROS levels. Interacts with TOM70; the interaction promotes translocation of RPS3 to the mitochondrion. Interacts (via N-terminus) with RELA (via N-terminus); the interaction enhances the DNA-binding activity of the NF-kappa-B p65-p50 complex. Interacts with NFKBIA; the interaction is direct and may bridge the interaction between RPS3 and RELA. Interacts with IKKB; the interaction phosphorylates RPS3 and enhances its translocation to the nucleus. Interacts (via KH domain) with MDM2 and TP53. Interacts with TRADD. Interacts with CRY1.
messages: Cytoplasm
messages: Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein OGG1. Enhances the uracil excision activity of UNG1. Also stimulates the cleavage of the phosphodiester backbone by APEX1. When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide. Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes. Represses its own translation by binding to its cognate mRNA. Binds to and protects TP53/p53 from MDM2-mediated ubiquitination. Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization. Involved in induction of apoptosis through its role in activation of CASP8. Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation.
messages: Methylation by PRMT1 is required for import into the nucleolus and for ribosome assembly.
messages: Mitochondrion inner membrane
messages: Nucleus
messages: Phosphorylation at Thr-221 by CDK1 occurs mainly in G2/M phase. Phosphorylation by PRKCD occurs on a non-ribosomal-associated form which results in translocation of RPS3 to the nucleus and enhances its endonuclease activity. Phosphorylated on Ser-209 by IKKB in response to activation of the NF-kappa-B p65-p50 complex which enhances the association of RPS3 with importin-alpha and mediates the nuclear translocation of RPS3. Phosphorylation by MAPK is required for translocation to the nucleus following exposure of cells to DNA damaging agents such as hydrogen peroxide. Phosphorylation by PKB/AKT mediates RPS3 nuclear translocation, enhances RPS3 endonuclease activity and suppresses RPS3-induced neuronal apoptosis.
messages: Sumoylation by SUMO1 enhances protein stability through increased resistance to proteolysis. Sumoylation occurs at one or more of the three consensus sites, Lys-18, Lys-214 and Lys-230.
messages: Ubiquitinated; ubiquitination is prevented by interaction with HSP90 which stabilizes the protein. Monoubiquitinated at Lys-214 by RNF10 and ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide. Deubiquitinated at Lys-214 by USP10, preventing degradation by the proteasome and promoting 40S ribosome subunit recycling following ribosome dissociation.
messages: Ufmylated by UFL1.
messages: nucleolus
messages: spindle

9823:ZNF643
gene id: 9823:ZNF643
uniprot id: A0A8D0I1A5
uniprot id: A0A8D0I1C4
uniprot id: F1SCQ7
names: Subcellular Location Annotation
messages: Nucleus

9823:CAVIN2
gene id: 9823:CAVIN2
uniprot id: A0A4X1SGA2
uniprot id: I3LDR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9823:DNAAF2
gene id: 9823:DNAAF2
uniprot id: A0A8D1QI77
uniprot id: F1SHZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

9823:AURKA
gene id: 9823:AURKA
uniprot id: A4UTN8
uniprot id: A5GFW1
uniprot id: Q4R1K4
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment (By similarity). Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase (By similarity). Autophosphorylated at Thr-288 upon TPX2 binding (By similarity). Thr-288 can be phosphorylated by several kinases, including PAK and PKA (By similarity). Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis (By similarity). Phosphorylation at Ser-342 decreases the kinase activity (By similarity). PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis (By similarity).
messages: Activation of CDK1, appears to be an upstream event of AURKA activation (By similarity). Phosphatase inhibitor-2 (PPP1R2) and TPX2 act also as activators (By similarity). Inactivated by the G2 checkpoint (By similarity). Inhibited by GADD45A and p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1) (By similarity). MLN8054 is also a potent and selective inhibitor (By similarity). Activated during the early phase of cilia disassembly in the presence of CIMAP3 (By similarity). Inhibited by the small molecule inhibitor VX-680 (By similarity).
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (By similarity). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (By similarity). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for initial activation of CDK1 at centrosomes (By similarity). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (By similarity). Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation (By similarity). Plays a role in microtubule remodeling during neurite extension (By similarity). Important for microtubule formation and/or stabilization (By similarity). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (By similarity). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (By similarity). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (By similarity).
messages: Part of a complex composed of NEDD9, AURKA and CTTN; within the complex NEDD9 acts as a scaffold protein and is required for complex formation (By similarity). Identified in a complex with AUNIP and NIN (By similarity). Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC (By similarity). Interacts also with its substrates ARHGEF2, BORA, KIF2A, PARD3, and p53/TP53 (By similarity). Interaction with BORA promotes phosphorylation of PLK1 (By similarity). Interacts with CIMAP3 (By similarity). Interacts with GADD45A, competing with its oligomerization (By similarity). Interacts (via C-terminus) with AUNIP (via C-terminus) (By similarity). Interacts with FRY; this interaction facilitates AURKA-mediated PLK1 phosphorylation (By similarity). Interacts with SIRT2 (By similarity). Interacts with MYCN; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN (By similarity). Interacts with HNRNPU (By similarity). Interacts with AAAS (By similarity). Interacts with KLHL18 and CUL3 (By similarity). Interacts with FOXP1 (By similarity). Interacts with HDAC6; AURKA-mediated phosphorylation of HDAC6 promotes deacetylation of alpha-tubulin (By similarity).
messages: Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome (By similarity). Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the CUL3-KLHL18 ligase leading to its activation at the centrosome which is required for initiating mitotic entry (By similarity). Ubiquitination mediated by CUL3-KLHL18 ligase does not lead to its degradation by the proteasome (By similarity).
messages: centriole
messages: centrosome
messages: cilium
messages: cilium basal body
messages: neuron projection
messages: spindle pole

9823:PLA2G1B
gene id: 9823:PLA2G1B
uniprot id: P00592
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.
messages: Acylation causes dimerization.
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Loss of activity upon alkylation of His-70 with p-bromo phenacyl bromide; Ca(2+) and Ba(2+) protect against inactivation.
messages: Monomer or homodimer.
messages: Regulated by bile acid salts. Up-regulated by cholate and down-regulated by taurochenodeoxycholate.
messages: Secreted
messages: Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:17603006). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (By similarity). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).

9823:TMTC4
gene id: 9823:TMTC4
uniprot id: A0A287A0I3
uniprot id: A0A4X1U7W2
uniprot id: A0A4X1UC06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9823:AVPR1B
gene id: 9823:AVPR1B
uniprot id: A0A4X1USR6
uniprot id: F1SF06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9823:WDR83OS
gene id: 9823:WDR83OS
uniprot id: A0A8D0PA01
uniprot id: A0A8D1HTP8
uniprot id: Q6Q7K0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Asterix family.
messages: Component of the PAT complex, composed of WDR83OS/Asterix and CCDC47. The PAT complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex.
messages: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein. Within the PAT subcomplex, WDR83OS/Asterix binds to and redirects the substrate to a location behind the SEC61 complex (By similarity).
messages: Endoplasmic reticulum membrane
messages: Expressed during early cleavage-stage embryos before zygotic gene activation (ZGA), metaphase II (MII) oocyte, 1-cell, and 2-cell stage embryos.

9823:RPS4X
gene id: 9823:RPS4X
uniprot id: A0A287B771
uniprot id: A0A8D0MBB3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9823:STT3B
gene id: 9823:STT3B
uniprot id: A0A4X1UDA4
uniprot id: F1RRF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9823:TFIP11
gene id: 9823:TFIP11
uniprot id: A0A480XBS3
uniprot id: Q06AK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2 (By similarity).
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity).
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9823:POU3F2
gene id: 9823:POU3F2
uniprot id: A0A4X1VGK5
uniprot id: A0A8W4F7H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9823:RAB21
gene id: 9823:RAB21
uniprot id: A0A287A4W6
uniprot id: A0A4X1W0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: trans-Golgi network

9823:RORA
gene id: 9823:RORA
uniprot id: A0A286ZJH8
uniprot id: A0A4X1TNF7
uniprot id: A0A8D1QKE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9823:LDHC
gene id: 9823:LDHC
uniprot id: Q9TSX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2.
messages: Possible role in sperm motility.

9823:CSN1S2
gene id: 9823:CSN1S2
uniprot id: P39036
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9823:CEP55
gene id: 9823:CEP55
uniprot id: A0A4X1UUU8
uniprot id: F1SC81
names: Subcellular Location Annotation
messages: Cytoplasm

9823:GFRA1
gene id: 9823:GFRA1
uniprot id: A0A287A1Q3
uniprot id: A0A8D0QCR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9823:PDIA6
gene id: 9823:PDIA6
uniprot id: A0A4X1UE18
uniprot id: E1CAJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Melanosome

9823:TM4SF18
gene id: 9823:TM4SF18
uniprot id: A0A4X1SY37
uniprot id: A0A8D0RCV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9823:TSPAN12
gene id: 9823:TSPAN12
uniprot id: A0A4X1W2C4
uniprot id: A0A8D1DR37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:BACE2
gene id: 9823:BACE2
uniprot id: A0A4X1TLE9
uniprot id: A0A5G2R620
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Membrane

9823:IL4
gene id: 9823:IL4
uniprot id: F1CFE1
uniprot id: Q04745
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
messages: Secreted

9823:LOC100525396
gene id: 9823:LOC100525396
uniprot id: A0A287AV32
uniprot id: A0A4X1T5B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9823:LOC100737764
gene id: 9823:LOC100737764
uniprot id: A0A4X1VMB5
names: Subcellular Location Annotation
messages: Membrane

9823:CDK5R1
gene id: 9823:CDK5R1
uniprot id: A7LNG6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit and a regulatory subunit.
messages: Membrane

9823:CLTB
gene id: 9823:CLTB
uniprot id: A0A287BFZ5
uniprot id: A0A8D0ITW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9823:TGS1
gene id: 9823:TGS1
uniprot id: A0A4X1SY52
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9823:KCNB1
gene id: 9823:KCNB1
uniprot id: O18868
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Acetylation occurs in pancreatic beta cells in response to stimulation by incretin hormones in a histone acetyltransferase (HAT)/histone deacetylase (HDAC)-dependent signaling pathway, promoting beta cell survival.
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Cell membrane
messages: Homotetramer or heterotetramer with KCNB2. Heterotetramer with non-conducting channel-forming alpha subunits such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1. Channel activity is regulated by association with ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3. Interacts with KCNV2 (By similarity). Self-associates (via N-terminus and C-terminus); self-association is required to regulate trafficking, gating and C-terminal phosphorylation-dependent modulation of the channel. Interacts (via C-terminus) with STX1A (via C-terminus); this decreases the rate of channel activation and increases the rate of channel inactivation in pancreatic beta cells, induces also neuronal apoptosis in response to oxidative injury as well as pore-independent enhancement of exocytosis in neuroendocrine cells, chromaffin cells, pancreatic beta cells and from the soma of dorsal root ganglia (DRG) neurons. Interacts (via N-terminus) with SNAP25; this decreases the rate of channel inactivation in pancreatic beta cells and also increases interaction during neuronal apoptosis in a N-methyl-D-aspartate receptor (NMDAR)-dependent manner. Interacts (via N-terminus and C-terminus) with VAMP2 (via N-terminus); stimulates channel inactivation rate. Interacts with CREB1; this promotes channel acetylation in response to stimulation by incretin hormones. Interacts (via N-terminus and C-terminus) with MYL12B. Interacts (via N-terminus) with PIAS3; this increases the number of functional channels at the cell surface. Interacts with SUMO1. Interacts (via phosphorylated form) with PTPRE; this reduces phosphorylation and channel activity in heterologous cells. Interacts (via phosphorylated FFAT motif) with VAPA and VAPB (By similarity).
messages: Inhibited by 12.7 nM stromatoxin 1 (ScTx1), a spider venom toxin of the tarantula S.calceata. Inhibited by 42 nM hanatoxin 1 (HaTx1), a spider venom toxin of the tarantula G.spatulata. Modestly sensitive to millimolar levels of tetraethylammonium (TEA). Modestly sensitive to millimolar levels of 4-aminopyridine (4-AP). Completely insensitive to toxins such as dendrotoxin (DTX) and charybdotoxin (CTX).
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Phosphorylated. Differential C-terminal phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating in hippocampal neurons. Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/dephosphorylation activities. Tyr-128 can be phosphorylated by Src and dephosphorylated by cytoplasmic form of the phosphatase PTPRE. CDK5-induced Ser-607 phosphorylation increases in response to acute blockade of neuronal activity. Phosphorylated on Tyr-128 by Src and on Ser-805 by MAPK14/P38MAPK; phosphorylations are necessary and sufficient for an increase in plasma membrane insertion, apoptotic potassium current surge and completion of the neuronal cell death program. Phosphorylated on Ser-520, Ser-607, Ser-656 and Ser-805 by CDK5; phosphorylation is necessary for KCNB1 channel clustering formation. The Ser-607 phosphorylation state differs between KCNB1-containing clusters on the proximal and distal portions of the axon initial segment (AIS). Highly phosphorylated on serine residues in the C-terminal cytoplasmic tail in resting neurons. Phosphorylated in pancreatic beta cells in response to incretin hormones stimulation in a PKA- and RPS6KA5/MSK1-dependent signaling pathway, promoting beta cell survival. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5; levels then increase to reach adult levels by P14. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are sensitive to calcineurin-mediated dephosphorylation contributing to the modulation of the voltage-dependent gating properties. Dephosphorylation by phosphatase PTPRE confers neuroprotection by its inhibitory influence on the neuronal apoptotic potassium current surge in a Zn(2+)-dependent manner. Dephosphorylated at Ser-607 by protein phosphatase PPP1CA. Hypoxia-, seizure- or glutamate-induced neuronal activity promote calcium/calcineurin-dependent dep…
messages: Postsynaptic cell membrane
messages: Sumoylated on Lys-475, preferentially with SUMO1; sumoylation induces a positive shift in the voltage-dependence of activation and inhibits channel activity. Sumoylation increases the frequency of repetitive action potential firing at the cell surface of hippocampal neurons and decreases its frequency in pancreatic beta cells. Desumoylated by SENP1.
messages: Synapse
messages: The FFAT motif is involved in the interaction with VAPA and VAPB and its phosphorylation regulates these interactions.
messages: The N-terminal and C-terminal cytoplasmic regions mediate homooligomerization; self-association is required to regulate trafficking, gating and C-terminal phosphorylation-dependent modulation of the channel. The N-terminal cytoplasmic region is important for interaction with other channel-forming alpha subunits and with ancillary beta subunits. The C-terminus is necessary and sufficient for the restricted localization to, and clustering within, both in soma and proximal portions of dendrite of neurons and in lateral membrane of non-neuronal polarized cells. The C-terminus is both necessary and sufficient as a mediator of cholinergic and calcium-stimulated modulation of channel cell membrane clustering localization and activity in hippocampal neurons.
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Also plays a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (By similarity). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells. Channel properties are also modulated by cytoplasmic ancillary beta subunits, such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assig…
messages: axon
messages: dendrite
messages: sarcolemma
messages: synaptosome

9823:ECH1
gene id: 9823:ECH1
uniprot id: Q3Y5G5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9823:CNOT3
gene id: 9823:CNOT3
uniprot id: A0A480S6G3
uniprot id: A0A8D1GKB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
messages: Nucleus
messages: P-body

9823:SCAMP3
gene id: 9823:SCAMP3
uniprot id: A0A4X1W036
uniprot id: F1RLJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9823:CD151
gene id: 9823:CD151
uniprot id: A0A4X1VSR2
uniprot id: F1RYZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:GDF2
gene id: 9823:GDF2
uniprot id: A0A8D1NGR3
names: Similarity
messages: Belongs to the TGF-beta family.

9823:LOC100152911
gene id: 9823:LOC100152911
uniprot id: A0A4X1SIT3
uniprot id: F1SP69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:S100A16
gene id: 9823:S100A16
uniprot id: A0A8D1E7G9
uniprot id: F2Z5M4
names: Similarity
messages: Belongs to the S-100 family.

9823:KEF22 p08
gene id: 9823:KEF22_p08
uniprot id: Q35915
uniprot id: Q71K73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

9823:DUT
gene id: 9823:DUT
uniprot id: A0A287AX05
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

9823:GSTK1
gene id: 9823:GSTK1
uniprot id: A0A4X1V0V8
uniprot id: F1SRV4
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

9823:CCNG2
gene id: 9823:CCNG2
uniprot id: A0A287A578
uniprot id: A0A8D1Q137
names: Similarity
messages: Belongs to the cyclin family.

9823:GPR83
gene id: 9823:GPR83
uniprot id: I3RLE0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:CWF19L1
gene id: 9823:CWF19L1
uniprot id: A0A4X1U4C8
uniprot id: A0A8D0ZQK0
names: Similarity
messages: Belongs to the CWF19 family.

9823:GSR
gene id: 9823:GSR
uniprot id: A0A8D1Q9F8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

9823:DBNDD2
gene id: 9823:DBNDD2
uniprot id: A0A4X1TTI0
uniprot id: A0A4X1TVM3
names: Similarity
messages: Belongs to the dysbindin family.

9823:KRT12
gene id: 9823:KRT12
uniprot id: A0A8D1H2B2
uniprot id: F1RXG3
names: Similarity
messages: Belongs to the intermediate filament family.

9823:ZC3H14
gene id: 9823:ZC3H14
uniprot id: A0A287AE38
uniprot id: A0A287B8R9
uniprot id: A0A4X1SXD2
uniprot id: A0A4X1SXD7
uniprot id: A0A4X1SYZ4
uniprot id: A0A8D0PJ20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZC3H14 family.
messages: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
messages: Nucleus speckle

9823:FOXI2
gene id: 9823:FOXI2
uniprot id: A0A4X1V8D8
uniprot id: F1SDK7
names: Subcellular Location Annotation
messages: Nucleus

9823:IDO1
gene id: 9823:IDO1
uniprot id: F6K2E8
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9823:RNF7
gene id: 9823:RNF7
uniprot id: A0A4X1T8U9
uniprot id: A0A4X1TAT7
names: Similarity
messages: Belongs to the RING-box family.

9823:OTULIN
gene id: 9823:OTULIN
uniprot id: A0A4X1TR93
uniprot id: A0A5G2QLW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9823:IPO8
gene id: 9823:IPO8
uniprot id: A0A4X1VLY1
uniprot id: A0A8D0N8A8
uniprot id: A0A8D1ACB4
names: Subcellular Location Annotation
messages: Cytoplasm

9823:AEBP1
gene id: 9823:AEBP1
uniprot id: A0A8D1PQV8
uniprot id: F1SSF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9823:GNAL
gene id: 9823:GNAL
uniprot id: A0A4X1VNM1
uniprot id: A0A8D1XY38
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9823:LOC100621657
gene id: 9823:LOC100621657
uniprot id: A0A5G2QAJ1
uniprot id: A0A8D0ZPN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SCML1
gene id: 9823:SCML1
uniprot id: A0A4X1V0F1
uniprot id: A0A8D1QXD0
names: Similarity
messages: Belongs to the SCM family.

9823:MPEG1
gene id: 9823:MPEG1
uniprot id: I3Y4E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9823:IL18RAP
gene id: 9823:IL18RAP
uniprot id: A0A8D0ZJQ9
uniprot id: F1STH2
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9823:SLC9A1
gene id: 9823:SLC9A1
uniprot id: P48762
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated at acidic pHs. Inhibited by cariporide and eniporide. Inhibited by amiloride and 5-amino-substituted derivatives. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) bind and differentially regulate SLC9A1 activity.
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (By similarity). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (By similarity).
messages: Homodimer; dimerization is crucial for its function (By similarity). Oligomer (By similarity). Interacts with CALM in a calcium-dependent manner (By similarity). Interacts with TESC (By similarity). Interacts (via the juxtamembrane region of the cytoplasmic C-terminal domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner (By similarity). Interacts with CHP2; the interaction occurs in a calcium-dependent manner (By similarity). Interacts with EZR; regulates the cytoskeletal interactions of SLC9A1 and promotes stress fiber formation (By similarity).
messages: O-glycosylated.
messages: Palmitoylated; may play a major role in SLC9A1 regulation.
messages: Phosphorylation at Thr-782 increases SLC9A1 activity. Specifically dephosphorylated at Thr-782 by PPP3CA that negatively regulates SLC9A1 activity. Phosphorylation at Ser-648 by AKT1 reduces SLC9A1 binding to CALM1.
messages: Predicted models used for more than 20 years predicted 10-12 transmembrane segments. Recently, the stucture of SLC9A1 has been solved and reveals that SLC9A1 posseses 13 transmembranes.
messages: The interacting region with TESC is conflicting: In human, it has been reported that SLC9A1 interacts with TESC via the juxtamembrane region of the cytoplasmic C-terminal domain, including residues 503-545. However, another publication has reported interaction with TESC via residues 633-818, the region of the cytoplasmic C-terminus more distal to the membrane.
messages: Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1.

9823:AP5M1
gene id: 9823:AP5M1
uniprot id: A0A287B4H1
uniprot id: A0A8D0SIB5
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9823:GADD45GIP1
gene id: 9823:GADD45GIP1
uniprot id: A0A286ZXA6
uniprot id: A0A4X1T8J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

9823:MYOD1
gene id: 9823:MYOD1
uniprot id: D2KPI9
uniprot id: P49811
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).
messages: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1. Interacts with DDX5. Interacts with CHD2. Interacts with TSC22D3 (By similarity). Interacts with SETD3 (By similarity). Interacts with P-TEFB complex; promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation (By similarity). Interacts with CSRP3 (By similarity). Interacts with NUPR1 (By similarity).
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity.
messages: Nucleus
messages: Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation (By similarity).
messages: Ubiquitinated on the N-terminus; which is required for proteasomal degradation.

9823:DTX3
gene id: 9823:DTX3
uniprot id: A0A4X1W5X4
uniprot id: A0A8D0MJI7
uniprot id: A0A8D1VPD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9823:TNK2
gene id: 9823:TNK2
uniprot id: A0A287B071
uniprot id: A0A287BC95
uniprot id: A0A480HY67
uniprot id: A0A480NSI8
uniprot id: A0A8D0PQR3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nucleus

9823:UBE2F
gene id: 9823:UBE2F
uniprot id: A0A4X1T4L2
uniprot id: A0A4X1T7P4
uniprot id: A0A5G2Q7M6
uniprot id: I3L574
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:DYNC2LI1
gene id: 9823:DYNC2LI1
uniprot id: A0A4X1SKQ0
uniprot id: A0A8D0LKK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

9823:KIF20A
gene id: 9823:KIF20A
uniprot id: A0A4X1V2Q7
uniprot id: A0A8D0WNP5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:IDH3A
gene id: 9823:IDH3A
uniprot id: A0A480YSS4
uniprot id: A0A8D0ZSH2
uniprot id: P56471
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
messages: Divalent metal cations; Mn(2+) or Mg(2+). Activity higher in presence of Mn(2+) than of Mg(2+). Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion
messages: The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT-binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits.

9823:SHANK1
gene id: 9823:SHANK1
uniprot id: A0A8D1R2L1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.
messages: Postsynaptic density

9823:BRMS1
gene id: 9823:BRMS1
uniprot id: A0A4X1TSR2
uniprot id: F1RUT0
names: Subcellular Location Annotation
messages: Nucleus

9823:CHUK
gene id: 9823:CHUK
uniprot id: A0A4X1U511
uniprot id: B0LXP6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:PPP1R14A
gene id: 9823:PPP1R14A
uniprot id: O18734
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Detected in aorta smooth muscle and bladder.
messages: Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
messages: Phosphorylation of Thr-38 induces a conformation change.

9823:VAMP8
gene id: 9823:VAMP8
uniprot id: A0A4X1W681
uniprot id: A0A8W4FA01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9823:PGM2L1
gene id: 9823:PGM2L1
uniprot id: A0A4X1UQV2
uniprot id: A0A8D1IDJ7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9823:ACKR1
gene id: 9823:ACKR1
uniprot id: A0A8D1GND3
uniprot id: Q70DY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Recycling endosome

9823:XK
gene id: 9823:XK
uniprot id: A0A286ZKL8
uniprot id: A0A4X1VJC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9823:SELRC1
gene id: 9823:SELRC1
uniprot id: A0A4X1WC97
uniprot id: A0A8D0P592
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space
messages: Required for assembly of mitochondrial respiratory chain complexes.

9823:NOL8
gene id: 9823:NOL8
uniprot id: A0A480JUS0
names: Subcellular Location Annotation
messages: nucleolus

9823:MAP4K2
gene id: 9823:MAP4K2
uniprot id: A0A287A9F0
uniprot id: A0A8D1LXC3
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9823:RPIA
gene id: 9823:RPIA
uniprot id: A2TLM1
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9823:UNC5B
gene id: 9823:UNC5B
uniprot id: A0A286ZIM0
uniprot id: Q2HXW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9823:CIAO1
gene id: 9823:CIAO1
uniprot id: A0A4X1VT24
uniprot id: A0A8D0XC22
uniprot id: A0A8D1EAG5
uniprot id: F1SU35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9823:HORMAD1
gene id: 9823:HORMAD1
uniprot id: E2IUK4
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Interacts with HORMAD2. Interacts with IHO1.
messages: Nucleus
messages: Phosphorylated at Ser-377 in a SPO11-dependent manner.
messages: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.

9823:SLC46A3
gene id: 9823:SLC46A3
uniprot id: A0A4X1TKX8
uniprot id: M3UZC6
names: Subcellular Location Annotation
messages: Membrane

9823:TIMM8B
gene id: 9823:TIMM8B
uniprot id: A0A8D1QIU9
uniprot id: F2Z5V7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9823:ARCN1
gene id: 9823:ARCN1
uniprot id: A0A4X1SPY8
uniprot id: A0A8D0QU81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9823:CHMP2B
gene id: 9823:CHMP2B
uniprot id: A0A287A1F6
uniprot id: A0A4X1UIP9
names: Similarity
messages: Belongs to the SNF7 family.

9823:SLC9A3R1
gene id: 9823:SLC9A3R1
uniprot id: A0A4X1SHQ2
uniprot id: B8XH67
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

9823:PIWIL2
gene id: 9823:PIWIL2
uniprot id: D9YJ49
uniprot id: I3LE69
names: Similarity
messages: Belongs to the argonaute family.

9823:GFM2
gene id: 9823:GFM2
uniprot id: A0A287BK99
uniprot id: A0A4X1SNY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9823:BGLAP
gene id: 9823:BGLAP
uniprot id: A0A4X1VY69
uniprot id: F6PUF1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9823:UXT
gene id: 9823:UXT
uniprot id: A0A8D1F7J7
uniprot id: A0A8D1PE43
names: Similarity
messages: Belongs to the UXT family.

9823:MYL7
gene id: 9823:MYL7
uniprot id: F1SSF9
names: Miscellaneous
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.
messages: This chain binds calcium.

9823:SH3GLB1
gene id: 9823:SH3GLB1
uniprot id: A0A288CG11
uniprot id: A0A4X1UB53
uniprot id: A0A4X1UCY7
uniprot id: A0A4X1UE41
uniprot id: A0A5G2QNQ3
uniprot id: A0A8D0QM53
uniprot id: D0G7F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9823:OGG1
gene id: 9823:OGG1
uniprot id: A0A4X1UWX2
uniprot id: A0A8D0IZQ7
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

9823:STC2
gene id: 9823:STC2
uniprot id: A8IKA3
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9823:IYD
gene id: 9823:IYD
uniprot id: Q6TA49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nitroreductase family.
messages: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (By similarity). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:15289438). The scavanged iodide can then reenter the hormone-producing pathways (By similarity). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (By similarity).
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Detected in thyroid (at protein level).
messages: Homodimer.

9823:BMP7
gene id: 9823:BMP7
uniprot id: A0A8D0PUH2
uniprot id: A0A8D0Q1I3
uniprot id: A5GFN1
uniprot id: A5GFN2
names: Similarity
messages: Belongs to the TGF-beta family.

9823:MRPL40
gene id: 9823:MRPL40
uniprot id: A0A286ZP98
uniprot id: A0A4X1UTT8
uniprot id: A0A5G2R2V2
uniprot id: A0A8D0SU37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9823:APOH
gene id: 9823:APOH
uniprot id: A0A140TAK8
uniprot id: A0A286ZFW3
uniprot id: A0A8D0IMU7
uniprot id: A0A8D1DIK0
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:SUMO4
gene id: 9823:SUMO4
uniprot id: A7WLI0
uniprot id: C7S2Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Interacts with SAE2. Covalently attached to a number of proteins (By similarity).
messages: Nucleus
messages: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I (By similarity).

9823:XPO6
gene id: 9823:XPO6
uniprot id: A0A4X1UMS9
uniprot id: F1RFG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9823:MAGOH
gene id: 9823:MAGOH
uniprot id: A0A4X1WAU1
uniprot id: A0A8D1A6S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9823:GATC
gene id: 9823:GATC
uniprot id: A0A4X1T4U0
uniprot id: A0A8D1YD56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9823:TMEM144
gene id: 9823:TMEM144
uniprot id: A0A8D0QYQ1
uniprot id: A0A8D1GQT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

9823:TESMIN
gene id: 9823:TESMIN
uniprot id: A0A4X1SNK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9823:SCGB1D1
gene id: 9823:SCGB1D1
uniprot id: Q863D3
names: Subcellular Location Annotation
messages: Secreted

9823:ACAN
gene id: 9823:ACAN
uniprot id: F1SKR0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:TMEM107
gene id: 9823:TMEM107
uniprot id: A0A8D0JTK5
uniprot id: I3LUH9
names: Subcellular Location Annotation
messages: Membrane

9823:PHGDH
gene id: 9823:PHGDH
uniprot id: A0A481BII5
uniprot id: A5GFY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
messages: Homotetramer.

9823:LOC100518305
gene id: 9823:LOC100518305
uniprot id: A0A8D1PTP4
names: Similarity
messages: Belongs to the apolipoprotein L family.

9823:CCNY
gene id: 9823:CCNY
uniprot id: A0A4X1TGS6
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9823:MYH7B
gene id: 9823:MYH7B
uniprot id: A0A4X1T8T2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: myofibril

9823:HSPH1
gene id: 9823:HSPH1
uniprot id: A4UTN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

9823:TIPIN
gene id: 9823:TIPIN
uniprot id: A0A8D1CAS8
uniprot id: F1SJJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

9823:VPS11
gene id: 9823:VPS11
uniprot id: A0A4X1SIU4
uniprot id: F1SAH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9823:NSA2
gene id: 9823:NSA2
uniprot id: A0A4X1SRK5
uniprot id: A0A8D0XX85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

9823:MYF5
gene id: 9823:MYF5
uniprot id: A0A8D0P588
uniprot id: M9V7C8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9823:CHMP4A
gene id: 9823:CHMP4A
uniprot id: A0A4X1SRC3
uniprot id: A0A8D0NNW3
names: Similarity
messages: Belongs to the SNF7 family.

9823:INHA
gene id: 9823:INHA
uniprot id: P04087
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Proteolytic processing yields a number of bioactive forms, consisting either solely of the mature alpha chain, of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, or of the entire proprotein.
messages: Secreted

9823:LOC100511340
gene id: 9823:LOC100511340
uniprot id: A0A4X1VK99
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ANXA13
gene id: 9823:ANXA13
uniprot id: A0A8D1HLV4
uniprot id: A0A8D1LI27
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9823:UBL3
gene id: 9823:UBL3
uniprot id: A0A287B7A4
uniprot id: A0A8D0NKV7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:HDAC3
gene id: 9823:HDAC3
uniprot id: A0A480Q1X2
uniprot id: A0A8D1F8K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

9823:TSHZ2
gene id: 9823:TSHZ2
uniprot id: A5GFT6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Interacts (via homeobox domain) with APBB1 (via PID domain 1).
messages: Nucleus
messages: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).
messages: Sumoylated.

9823:DPT
gene id: 9823:DPT
uniprot id: A0A286ZVB7
uniprot id: A0A8D1QBU2
names: Similarity
messages: Belongs to the dermatopontin family.

9823:HKDC1
gene id: 9823:HKDC1
uniprot id: A0A286ZQ27
uniprot id: A0A4X1TKL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9823:MAP2
gene id: 9823:MAP2
uniprot id: A0A287B3S9
uniprot id: A0A8D0LDX5
uniprot id: A0A8D0YQA1
uniprot id: A0A8D1VPX4
uniprot id: A0A8D1ZII2
uniprot id: A0A8D2CD15
uniprot id: F1SSS6
names: Subcellular Location Annotation
messages: cytoskeleton

9823:RIOK1
gene id: 9823:RIOK1
uniprot id: A0A8D1VCF9
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9823:KCNV1
gene id: 9823:KCNV1
uniprot id: A0A8D1DR12
uniprot id: F1S1I3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9823:NLN
gene id: 9823:NLN
uniprot id: A0A480E8P3
uniprot id: Q02038
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1.
messages: Mitochondrion
messages: Predominantly expressed in the liver, kidney and adrenal gland.
messages: Truncated due to inclusion of exon 4 which leads to premature stop codon.

9823:STK38L
gene id: 9823:STK38L
uniprot id: A0A8D0WXD3
uniprot id: I3LN61
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:KCNMB1
gene id: 9823:KCNMB1
uniprot id: A0A8D0R9C7
uniprot id: F1RRX5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9823:FMO3
gene id: 9823:FMO3
uniprot id: A0A4X1V7C5
uniprot id: I3LS94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Membrane
messages: Microsome membrane

9823:CHMP5
gene id: 9823:CHMP5
uniprot id: A0A4X1UQ22
uniprot id: A0A8D0YFJ8
names: Similarity
messages: Belongs to the SNF7 family.

9823:CXCL16
gene id: 9823:CXCL16
uniprot id: A0A8D0ZDM9
uniprot id: Q9GKE2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Glycosylated.
messages: Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity).
messages: Membrane

9823:PDE6D
gene id: 9823:PDE6D
uniprot id: A0A480V9G7
uniprot id: A0A4X1THT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9823:CMTR1
gene id: 9823:CMTR1
uniprot id: A0A481BL07
uniprot id: A0A4X1SRQ0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

9823:GPR4
gene id: 9823:GPR4
uniprot id: P50132
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO(2)/H(+).

9823:KCNA4
gene id: 9823:KCNA4
uniprot id: A0A480EXH4
uniprot id: A0A4X1SXT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: axon

9823:CLDN5
gene id: 9823:CLDN5
uniprot id: A0A8D1SRL8
uniprot id: C3VML1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:FIBIN
gene id: 9823:FIBIN
uniprot id: A0A8D1AQY5
uniprot id: I3L9M3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9823:SLC43A2
gene id: 9823:SLC43A2
uniprot id: A0A480EJY2
uniprot id: A0A4X1U286
uniprot id: A0A4X1U7I0
uniprot id: A0A8W4FL32
names: Subcellular Location Annotation
messages: Membrane

9823:SPPL3
gene id: 9823:SPPL3
uniprot id: A0A8D0KH60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9823:LOC100154303
gene id: 9823:LOC100154303
uniprot id: A0A4X1UWQ5
uniprot id: F1S8J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100522725
gene id: 9823:LOC100522725
uniprot id: A0A8D1UTS5
uniprot id: F1RPZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9823:TSN
gene id: 9823:TSN
uniprot id: A0A286ZHZ3
uniprot id: A0A8D0QSX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9823:RASSF1
gene id: 9823:RASSF1
uniprot id: A0A8D0XBF7
uniprot id: A0A8D1HPQ5
names: Subcellular Location Annotation
messages: cytoskeleton

9823:LOC100155760
gene id: 9823:LOC100155760
uniprot id: A0A8D0U5V6
uniprot id: Q29084
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:ADAMTS9
gene id: 9823:ADAMTS9
uniprot id: A0A4X1VEL0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:BTF3
gene id: 9823:BTF3
uniprot id: A0A287BJ88
uniprot id: A0A4X1SMA4
uniprot id: A0A4X1SNH4
uniprot id: A0A8D0IHX6
names: Similarity
messages: Belongs to the NAC-beta family.

9823:RPLP1
gene id: 9823:RPLP1
uniprot id: A1XQU7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.
messages: Ubiquitinated at Lys-92 and Lys-93 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).

9823:S100G
gene id: 9823:S100G
uniprot id: P02632
names: Similarity
messages: Belongs to the S-100 family.

9823:CDC42SE2
gene id: 9823:CDC42SE2
uniprot id: A0A4X1UMB4
uniprot id: A0A8D0XNB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9823:FSCN3
gene id: 9823:FSCN3
uniprot id: A0A8D1F060
uniprot id: Q2I373
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9823:RARRES2
gene id: 9823:RARRES2
uniprot id: A0A8D1VUF9
uniprot id: B0LUW3
names: Subcellular Location Annotation
messages: Secreted

9823:TUBGCP3
gene id: 9823:TUBGCP3
uniprot id: A0A4X1TX02
uniprot id: F1RN46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9823:ACTN2
gene id: 9823:ACTN2
uniprot id: A0A8D0XC36
uniprot id: F1RHL9
names: Similarity
messages: Belongs to the alpha-actinin family.

9823:CD27
gene id: 9823:CD27
uniprot id: A0A4X1UUI8
uniprot id: L7QHB1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DOCK10
gene id: 9823:DOCK10
uniprot id: A0A481AKF2
names: Similarity
messages: Belongs to the DOCK family.

9823:BDKRB1
gene id: 9823:BDKRB1
uniprot id: Q8HZN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
messages: Cell membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9823:SLC10A1
gene id: 9823:SLC10A1
uniprot id: A0A8D0ZAJ9
uniprot id: F1S4B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9823:CDC42EP2
gene id: 9823:CDC42EP2
uniprot id: A0A4X1TEX2
uniprot id: F1RQV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9823:RNPC3
gene id: 9823:RNPC3
uniprot id: A0A4X1TI31
uniprot id: A0A4X1TMC8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

9823:PMEPA1
gene id: 9823:PMEPA1
uniprot id: A0A8D1C8F5
uniprot id: A5GFP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9823:LOC100519295
gene id: 9823:LOC100519295
uniprot id: A0A4X1VKU6
uniprot id: I3LNY8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9823:EXT1
gene id: 9823:EXT1
uniprot id: A0A8D1GGY4
uniprot id: F1S274
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:UROC1
gene id: 9823:UROC1
uniprot id: A0A480TLP6
uniprot id: A0A4X1U9M7
names: Similarity
messages: Belongs to the urocanase family.

9823:LOC100520823
gene id: 9823:LOC100520823
uniprot id: A0A5G2R8X1
uniprot id: A0A8D0YFB9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GOT2
gene id: 9823:GOT2
uniprot id: A0A480XZ96
uniprot id: P00506
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
messages: Cell membrane
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
messages: Mitochondrion matrix

9823:LOC100622479
gene id: 9823:LOC100622479
uniprot id: A0A5G2QV83
uniprot id: A0A8D1AB39
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SNX9
gene id: 9823:SNX9
uniprot id: A0A4X1VT93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9823:ARL3
gene id: 9823:ARL3
uniprot id: A0A480SIX0
uniprot id: Q52NJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cytoplasm
messages: Found in a complex with ARL3, RP2 and UNC119 (or UNC119B); RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119 (or UNC119B). Interacts with RP2; interaction is direct and stimulated with the activated GTP-bound form of ARL3. Interacts with SYS1. Interacts with ARL2BP; the GTP-bound form interacts with ARL2BP. Microtubule-associated protein. Does not interact with TBCC (By similarity). Interacts with RP2. Interacts with PDE6D; the interaction occurs specifically with the GTP-bound form of ARL3. Interacts with GGA1; the interaction recruits PKD1:PKD2 complex to trans-Golgi network and is required for ciliary targeting of PKD1:PKD2 complex (By similarity). Interacts with DNAAF9 (By similarity).
messages: Golgi apparatus membrane
messages: Nucleus
messages: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity).
messages: centrosome
messages: cilium
messages: spindle

9823:MYCL
gene id: 9823:MYCL
uniprot id: A0A4X1VU92
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9823:ETFRF1
gene id: 9823:ETFRF1
uniprot id: A0A287BTM9
uniprot id: A0A8D0TSS5
names: Similarity
messages: Belongs to the complex I LYR family.

9823:ACYP1
gene id: 9823:ACYP1
uniprot id: A0A8D0Z570
uniprot id: A0A8D1EZS6
uniprot id: P24540
names: Similarity
names: Tissue Specificity
messages: Belongs to the acylphosphatase family.
messages: Organ-common type isozyme is found in many different tissues.

9823:MAT1A
gene id: 9823:MAT1A
uniprot id: A0A4X1SHI9
uniprot id: A0A8D0Q1L1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9823:GAL
gene id: 9823:GAL
uniprot id: P07480
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.
messages: Secreted

9823:NDUFA3
gene id: 9823:NDUFA3
uniprot id: A0A4X1VQ42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9823:LOC100513271
gene id: 9823:LOC100513271
uniprot id: A0A4X1V0B6
uniprot id: F1S9Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PLPP4
gene id: 9823:PLPP4
uniprot id: A0A480QNQ9
uniprot id: A0A8D0UUK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9823:TMEM17
gene id: 9823:TMEM17
uniprot id: A0A8D1LXF4
uniprot id: I3LBE3
names: Subcellular Location Annotation
messages: Membrane

9823:NKIRAS2
gene id: 9823:NKIRAS2
uniprot id: A0A4X1U719
uniprot id: F2Z555
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9823:SF3B6
gene id: 9823:SF3B6
uniprot id: A0A8D1IBA3
uniprot id: F2Z5F1
names: Subcellular Location Annotation
messages: Nucleus

9823:COPS7A
gene id: 9823:COPS7A
uniprot id: A0A4X1UXG2
uniprot id: A0A8W4FDR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9823:MSH6
gene id: 9823:MSH6
uniprot id: A0A4X1SFD9
uniprot id: I3LUG7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

9823:SNX30
gene id: 9823:SNX30
uniprot id: A0A287A447
uniprot id: A0A4X1V4I7
names: Similarity
messages: Belongs to the sorting nexin family.

9823:GOT1
gene id: 9823:GOT1
uniprot id: A0A1B2TT55
uniprot id: P00503
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:4634443). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity).
messages: Cytoplasm
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9823:KAT7
gene id: 9823:KAT7
uniprot id: A0A8D0TF71
uniprot id: A0A8D0ZA13
uniprot id: D3K5K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9823:PSEN2
gene id: 9823:PSEN2
uniprot id: Q0MS45
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase A22A family.
messages: Detected in the embryonic brain in frontal cortex (at protein level). Expressed in the developing brain: frontal cortex, cerebellum, hippocampus, basal ganglia and brain stem. Localized mainly in neuronal cells and astrocytes.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Interacts with DOCK3. Interacts with HERPUD1, FLNA, FLNB and PARL (By similarity).
messages: Phosphorylated on serine residues.
messages: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
messages: The PAL motif is required for normal active site conformation.

9823:CD3E
gene id: 9823:CD3E
uniprot id: Q7YRN2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
messages: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with CD6. Interacts with NCK1. Interacts with NUMB; this interaction is important for TCR-CD3 internalization and subsequent degradation.

9823:MDM2
gene id: 9823:MDM2
uniprot id: A0A286ZIP0
uniprot id: A0A4X1VXV6
uniprot id: A0A8D0IL03
uniprot id: A0A8D0IL90
uniprot id: A0A8D1SCC5
uniprot id: A0A8D1WMJ8
uniprot id: A7Y496
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9823:EGR2
gene id: 9823:EGR2
uniprot id: A0A8D0M3F9
uniprot id: A1XSY8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated at Lys-246. May be deacetylated by HDAC6, HDAC10 or SIRT1.
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity.
messages: Interacts with HCFC1 (By similarity). Interacts with WWP2 (By similarity). Interacts with UBC9 (By similarity). Interacts with CITED1 (By similarity). Interacts (via phosphorylated form) with SFN (By similarity).
messages: Nucleus
messages: Sequence-specific DNA-binding transcription factor (By similarity). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity).
messages: Ubiquitinated by WWP2 leading to proteasomal degradation.

9823:UBALD2
gene id: 9823:UBALD2
uniprot id: A0A4X1UY87
uniprot id: A0A8D0UTP0
uniprot id: I3LEC8
names: Similarity
messages: Belongs to the UBALD family.

9823:RDH11
gene id: 9823:RDH11
uniprot id: A0A8D1YEA1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:IMMP1L
gene id: 9823:IMMP1L
uniprot id: A0A287A8V6
uniprot id: A0A287AVY3
uniprot id: A0A4X1SX34
uniprot id: A0A8D1KF23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9823:TGFB3
gene id: 9823:TGFB3
uniprot id: A0A8D0YVX8
uniprot id: K7GSJ9
uniprot id: P15203
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Interacts with ASPN (By similarity). Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide: Interacts with Transforming growth factor beta-3 (TGF-beta-3) chain; interaction is non-covalent and maintains (TGF-beta-3) in a latent state (By similarity). Latency-associated peptide: Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-3 and promote epithelial fusion during palate development (By similarity). Latency-associated peptide: Interacts (via cell attachment site) with integrins, leading to release of the active TGF-beta-3 (By similarity). Transforming growth factor beta-3: Homodimer; disulfide-linked (By similarity). Transforming growth factor beta-3: Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
messages: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity).
messages: Secreted
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: Transforming growth factor beta-3 proprotein: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-3 (TGF-beta-3) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-3 inactive.
messages: Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).
messages: extracellular matrix

9823:LOC100516990
gene id: 9823:LOC100516990
uniprot id: A0A286ZW50
uniprot id: A0A4X1VDB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ZHX1
gene id: 9823:ZHX1
uniprot id: A0A8D1FIX8
uniprot id: F1RR15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9823:SQSTM1
gene id: 9823:SQSTM1
uniprot id: A0A287BLE1
uniprot id: A0A480K284
uniprot id: A0A8D0YZY4
uniprot id: A0A8D1YAK0
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9823:DEDD
gene id: 9823:DEDD
uniprot id: A0A8D0NS01
uniprot id: F1S193
names: Subcellular Location Annotation
messages: nucleolus

9823:KLC2
gene id: 9823:KLC2
uniprot id: A0A480I2E4
uniprot id: A0A8D1RD32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9823:IGF1
gene id: 9823:IGF1
uniprot id: A0A288CFX8
uniprot id: A0A8D0KJC7
uniprot id: A0A8D0UYR0
uniprot id: A0A8D1ETG0
uniprot id: G9BFS5
uniprot id: G9BFS9
uniprot id: I3LBI3
uniprot id: P16545
uniprot id: Q45QB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).

9823:FADS1
gene id: 9823:FADS1
uniprot id: A8UHA7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9823:PDXK
gene id: 9823:PDXK
uniprot id: O46560
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is increased in the presence of K(+)or Na(+).
messages: Belongs to the pyridoxine kinase family.
messages: Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (PubMed:9924807) (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity).
messages: Divalent metal cations. Zn(2+) is more efficient than Mg(2+).
messages: Homodimer.
messages: The N-terminus is blocked.
messages: cytosol

9823:SLCO2A1
gene id: 9823:SLCO2A1
uniprot id: A0A4X1TUR3
uniprot id: Q2QEH5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:CYP21A2
gene id: 9823:CYP21A2
uniprot id: A0A5G2QLE9
uniprot id: A0A8D2C404
uniprot id: P15540
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: The leucine-rich hydrophobic amino acid N-terminal region probably helps to anchor the protein to the microsomal membrane.

9823:PPBP
gene id: 9823:PPBP
uniprot id: P43030
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemoattractant factor for neutrophils.
messages: Secreted

9823:LAMP3
gene id: 9823:LAMP3
uniprot id: A0A287BFU9
uniprot id: A0A480SDB7
uniprot id: A0A8D0RWP6
uniprot id: A0A8D0S198
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9823:HNF4A
gene id: 9823:HNF4A
uniprot id: A0A288CG37
uniprot id: A0A8D1JH95
uniprot id: Q1I181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:METTL6
gene id: 9823:METTL6
uniprot id: A0A8D0RC07
uniprot id: A0A8D0RMK9
uniprot id: A0A8D1H645
uniprot id: A0A8D1K4E4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9823:DUSP10
gene id: 9823:DUSP10
uniprot id: A0A8D0J0P1
uniprot id: F1S9I4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9823:LOC100621954
gene id: 9823:LOC100621954
uniprot id: A0A5G2R433
uniprot id: A0A8D0RN57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TIPARP
gene id: 9823:TIPARP
uniprot id: A0A4X1SJL9
uniprot id: A0A8D0IZD6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9823:LIN52
gene id: 9823:LIN52
uniprot id: A0A8D0QTU8
uniprot id: A0A8D0Y1X6
names: Similarity
messages: Belongs to the lin-52 family.

9823:CCDC43
gene id: 9823:CCDC43
uniprot id: A0A480TVB8
uniprot id: A0A4X1THW7
names: Similarity
messages: Belongs to the CCDC43 family.

9823:MYO7A
gene id: 9823:MYO7A
uniprot id: A5A782
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9823:CLK1
gene id: 9823:CLK1
uniprot id: A0A8D0W0H3
uniprot id: B1A9K1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:SPAI-2
gene id: 9823:SPAI-2
uniprot id: P16225
names: Domain
names: Function
names: PTM
names: Tissue Specificity
messages: Inhibits Na(+),K(+) ATPase by the competitive mode against Na(+).
messages: Small intestine > large intestine. The plasma contains the pro-SPAI form circulating.
messages: The repetitive domain of pro-SPAI serves as a substrate for transglutaminase.
messages: The short form (AA 127-187) may be an artifact due to the strongly acidic conditions of the duodenum. The pro-SPAI form may be the native form.

9823:ARRDC4
gene id: 9823:ARRDC4
uniprot id: A0A4X1ULW1
uniprot id: A0A8D0QNF2
names: Similarity
messages: Belongs to the arrestin family.

9823:DDX39B
gene id: 9823:DDX39B
uniprot id: Q29024
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DECD subfamily.
messages: Cytoplasm
messages: Homodimer, and heterodimer with DDX39A. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex bridges ALYREF/THOC4 and the THO complex, and, in a ATP-dependent manner, ALYREF/THOC4 and SARNP/CIP29. Component of the spliceosome. Interacts directly with U2AF2. Interacts with RBM8A, RNPS1 and SRRM1, FYTTD1/UIF, THOC1, MX1 and POLDIP3. Interacts with LUZP4.
messages: Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.
messages: Nucleus
messages: Nucleus speckle
messages: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [] reporting a stimulatory effect.
messages: The helicase C-terminal domain mediates interaction with ALYREF/THOC4.

9823:LOC100519633
gene id: 9823:LOC100519633
uniprot id: A0A8D0YM58
uniprot id: F1SSI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CKS2
gene id: 9823:CKS2
uniprot id: A0A4X1SFE7
uniprot id: A0A8D1ASZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9823:NR2C1
gene id: 9823:NR2C1
uniprot id: A0A8D0SA00
uniprot id: A0A8D1T6A0
uniprot id: F1SQP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:DCLRE1B
gene id: 9823:DCLRE1B
uniprot id: A0A8D1W758
uniprot id: F1SBR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9823:GTF2A2
gene id: 9823:GTF2A2
uniprot id: A0A480PU90
uniprot id: A0A4X1TRI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9823:PAX6
gene id: 9823:PAX6
uniprot id: A0A4X1SWS9
uniprot id: A0A8D0V8R2
uniprot id: A0A8D1F5F2
uniprot id: F2Z5M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9823:SYNE2
gene id: 9823:SYNE2
uniprot id: A0A480L0G3
uniprot id: A0A4X1WCF0
names: Similarity
messages: Belongs to the nesprin family.

9823:RAD23B
gene id: 9823:RAD23B
uniprot id: A0A480DNV8
uniprot id: A0A4X1VCP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9823:IFN-ALPHA-8
gene id: 9823:IFN-ALPHA-8
uniprot id: A0A8D0SHB6
uniprot id: Q0GC46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:PLIN2
gene id: 9823:PLIN2
uniprot id: A0A287AAY1
uniprot id: A0A4X1WBQ4
uniprot id: A0A8D1HAG0
uniprot id: D0G0B6
uniprot id: Q9MZE5
names: Similarity
messages: Belongs to the perilipin family.

9823:SPDL1
gene id: 9823:SPDL1
uniprot id: A0A8D0JIV6
uniprot id: I3LS43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

9823:RPL34
gene id: 9823:RPL34
uniprot id: Q29223
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL34 family.
messages: Component of the large ribosomal subunit (PubMed:24930395). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:24930395).
messages: Component of the large ribosomal subunit.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: cytosol

9823:SPARCL1
gene id: 9823:SPARCL1
uniprot id: A0A287BRY6
uniprot id: A0A8D1YSY6
uniprot id: A0A8D2C7R4
uniprot id: A3RIE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9823:RRM2B
gene id: 9823:RRM2B
uniprot id: A0A480TJS0
uniprot id: A0A4X1TTB9
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

9823:PIGP
gene id: 9823:PIGP
uniprot id: A0A4X1TPU0
uniprot id: A0A8D0MJD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

9823:PC
gene id: 9823:PC
uniprot id: Q7YS28
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

9823:PIK3IP1
gene id: 9823:PIK3IP1
uniprot id: A0A4X1V910
uniprot id: A0A8D1GNM2
uniprot id: F1RPC1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:FAM151B
gene id: 9823:FAM151B
uniprot id: A0A480K489
uniprot id: A0A4X1T6F7
names: Similarity
messages: Belongs to the FAM151 family.

9823:MORF4L1
gene id: 9823:MORF4L1
uniprot id: A0A4X1US98
uniprot id: A0A4X1UUF6
uniprot id: F1RKS0
uniprot id: K7GQW8
names: Subcellular Location Annotation
messages: Nucleus

9823:NME3
gene id: 9823:NME3
uniprot id: A0A4X1VZ23
uniprot id: A0A8D1WEU5
uniprot id: F1RG17
names: Similarity
messages: Belongs to the NDK family.

9823:GPER1
gene id: 9823:GPER1
uniprot id: A0A8D0ZN56
uniprot id: I3LSZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:CELF3
gene id: 9823:CELF3
uniprot id: A0A8D1GTG1
uniprot id: A0A8D1KLC3
uniprot id: F1ST15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

9823:GDF10
gene id: 9823:GDF10
uniprot id: A0A4X1VFY0
uniprot id: F1SEL5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9823:WDR91
gene id: 9823:WDR91
uniprot id: A0A480JW78
uniprot id: A0A4X1VS01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9823:DOK1
gene id: 9823:DOK1
uniprot id: A0A4X1W6T3
uniprot id: B7U6F5
uniprot id: F1SNV8
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9823:PDE3A
gene id: 9823:PDE3A
uniprot id: Q9XSW7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9823:RPS26
gene id: 9823:RPS26
uniprot id: P49171
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the 40S small ribosomal subunit.
messages: Component of the small ribosomal subunit (PubMed:24930395). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:24930395).
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9823:UBA3
gene id: 9823:UBA3
uniprot id: A0A287AU03
uniprot id: A0A4X1VAU4
uniprot id: A0A4X1VBU5
uniprot id: A0A4X1VDC4
uniprot id: A0A5G2QVD2
uniprot id: A0A8D2AB53
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

9823:ANKRD1
gene id: 9823:ANKRD1
uniprot id: Q865U8
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Down-regulated by doxorubicin (adriamycin), in vitro.
messages: Expressed in heart. In postnatal neonatal heart, it is expressed in an asymmetrical way; left ventricle favored towards right ventricle. Whether or not this could be correlated with a hypertrophic heart is still a matter of debate. Levels increase gradually from newborn to adult.
messages: Interacts with TTN/titin and YBX1.
messages: May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity).
messages: Nucleus

9823:PSMD12
gene id: 9823:PSMD12
uniprot id: A0A4X1SWC8
uniprot id: A0A4X1SWJ0
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

9823:LOC100154647
gene id: 9823:LOC100154647
uniprot id: A0A480DLH8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:LOC100511243
gene id: 9823:LOC100511243
uniprot id: A0A4X1VJ02
uniprot id: F1RMD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CPNE5
gene id: 9823:CPNE5
uniprot id: A0A287A2T7
uniprot id: A0A287AMN8
uniprot id: A0A4X1SSP6
uniprot id: A0A4X1SSR5
names: Similarity
messages: Belongs to the copine family.

9823:CDH11
gene id: 9823:CDH11
uniprot id: A0A8D1BCQ2
uniprot id: F1RFU7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9823:PSME2
gene id: 9823:PSME2
uniprot id: Q863Z0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PA28 family.
messages: Heterodimer of PSME1 and PSME2, which forms a hexameric ring.
messages: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity).

9823:APOA2
gene id: 9823:APOA2
uniprot id: A0A481BCM9
uniprot id: A0A4X1VK69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein A2 family.
messages: Secreted

9823:TIMM10B
gene id: 9823:TIMM10B
uniprot id: A0A5G2R1A5
uniprot id: A0A8D1E8E8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9823:CXCR6
gene id: 9823:CXCR6
uniprot id: A0A4X1TC43
uniprot id: Q6YT44
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:PABPC4
gene id: 9823:PABPC4
uniprot id: A0A287BQ02
uniprot id: A0A4X1VV02
uniprot id: A0A4X1VW37
uniprot id: A0A8D1UNY1
uniprot id: F1SV06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9823:DYNLRB1
gene id: 9823:DYNLRB1
uniprot id: A0A4X1T336
uniprot id: A0A8D0SJ55
uniprot id: A0A8D1D4D4
uniprot id: A0A8D1YUA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9823:KIF16B
gene id: 9823:KIF16B
uniprot id: A0A8D1KLH3
uniprot id: A0A8D1QTH4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:CYP2J34
gene id: 9823:CYP2J34
uniprot id: A0A8D1FXM9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:SERPINB7
gene id: 9823:SERPINB7
uniprot id: A0A8D1T114
uniprot id: F1SMW6
names: Similarity
messages: Belongs to the serpin family.

9823:COMT
gene id: 9823:COMT
uniprot id: A0A4X1URU2
uniprot id: D3K5L3
uniprot id: F1RHN3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
messages: Cell membrane

9823:FAM105A
gene id: 9823:FAM105A
uniprot id: A0A287AVS5
uniprot id: A0A4X1TLI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9823:OST4
gene id: 9823:OST4
uniprot id: A0A4X1TTR5
uniprot id: A0A8W4FP98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LOC100152306
gene id: 9823:LOC100152306
uniprot id: A0A480SJC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9823:OSTF1
gene id: 9823:OSTF1
uniprot id: Q8MJ49
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
messages: Interacts with SRC and SMN1. Interacts with FASLG (By similarity).
messages: The SH3 domain mediates interaction with SMN1.

9823:HOXD9
gene id: 9823:HOXD9
uniprot id: A0A8D1TV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9823:C9H11orf70
gene id: 9823:C9H11orf70
uniprot id: A0A4X1TMZ0
uniprot id: F1SV73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

9823:BTAF1
gene id: 9823:BTAF1
uniprot id: A0A287AFM0
uniprot id: A0A8D1NW12
names: Subcellular Location Annotation
messages: Nucleus

9823:DDX50
gene id: 9823:DDX50
uniprot id: A0A4X1TLH4
uniprot id: A0A8D0NQ41
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9823:LOC100512466
gene id: 9823:LOC100512466
uniprot id: A0A286ZPN3
uniprot id: A0A4X1W9W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SENP8
gene id: 9823:SENP8
uniprot id: A0A8D0RZ61
uniprot id: I3L5H4
names: Similarity
messages: Belongs to the peptidase C48 family.

9823:STX19
gene id: 9823:STX19
uniprot id: A0A8D0IVL3
uniprot id: I3LSW1
names: Similarity
messages: Belongs to the syntaxin family.

9823:CDPF1
gene id: 9823:CDPF1
uniprot id: A0A4X1W3S6
uniprot id: F1SM77
names: Similarity
messages: Belongs to the CDPF1 family.

9823:FCN1
gene id: 9823:FCN1
uniprot id: Q29042
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ficolin lectin family.
messages: Cell membrane
messages: Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (By similarity).
messages: Homotrimer. Interacts with elastin/ELN. Interacts (via Fibrinogen C-terminal domain) with FFAR2. Interacts with CRP; may regulate monocyte activation by FCN1.
messages: Most abundantly expressed in placenta and lung.
messages: Secreted
messages: The fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates and tethering to the cell surface in monocytes and granulocytes. The domain undergoes a conformational switch at pH under 6.2, and looses its carbohydrate-binding ability.

9823:MB21D2
gene id: 9823:MB21D2
uniprot id: A0A8D1E2P2
uniprot id: F1SFH0
names: Similarity
messages: Belongs to the mab-21 family.

9823:ACTL7B
gene id: 9823:ACTL7B
uniprot id: A0A8D1MNQ7
uniprot id: F1SP30
names: Similarity
messages: Belongs to the actin family.

9823:CCDC94
gene id: 9823:CCDC94
uniprot id: A0A480PXK7
uniprot id: A0A4X1VM71
uniprot id: A0A4X1VTX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

9823:ADK
gene id: 9823:ADK
uniprot id: A0A287ASQ2
uniprot id: A0A4X1SPA3
uniprot id: A0A4X1SPB8
uniprot id: A0A5G2R0F5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9823:NUS1
gene id: 9823:NUS1
uniprot id: A0A8D1FH46
uniprot id: I3LLX5
names: Similarity
messages: Belongs to the UPP synthase family.

9823:EDN3
gene id: 9823:EDN3
uniprot id: A5A752
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides.
messages: Secreted

9823:GLDN
gene id: 9823:GLDN
uniprot id: A0A4X1SZI4
uniprot id: F1RYN3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:MX1
gene id: 9823:MX1
uniprot id: P27594
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: By type I and type III interferons.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).
messages: ISGylated.
messages: Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles.
messages: The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.
messages: The middle domain mediates self-assembly and oligomerization.
messages: perinuclear region

9823:LOC100738212
gene id: 9823:LOC100738212
uniprot id: A0A4X1V7H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:DUOXA1
gene id: 9823:DUOXA1
uniprot id: A0A4X1VEG9
uniprot id: A0A8D1VDV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9823:HNRNPF
gene id: 9823:HNRNPF
uniprot id: A0A4X1U566
uniprot id: F1RG16
names: Subcellular Location Annotation
messages: nucleoplasm

9823:NUMB
gene id: 9823:NUMB
uniprot id: A0A4X1TLG8
uniprot id: A0A4X1TRB4
uniprot id: A0A8D0TYJ7
uniprot id: A0A8D0YV15
uniprot id: A0A8D1S0X7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9823:SRXN1
gene id: 9823:SRXN1
uniprot id: A0A8D1VMI3
names: Similarity
messages: Belongs to the sulfiredoxin family.

9823:PLPPR2
gene id: 9823:PLPPR2
uniprot id: A0A4X1VL51
uniprot id: A0A8D0W075
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9823:FABP2
gene id: 9823:FABP2
uniprot id: A8W348
uniprot id: Q45KW7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity).
messages: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
messages: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

9823:S100A11
gene id: 9823:S100A11
uniprot id: P31950
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the S-100 family.
messages: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.
messages: Cytoplasm
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.
messages: Nucleus
messages: Phosphorylation at Thr-8 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.

9823:CXHXorf23
gene id: 9823:CXHXorf23
uniprot id: A0A480NUY6
uniprot id: A0A4X1V7P7
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9823:LOC100156107
gene id: 9823:LOC100156107
uniprot id: A0A286ZM51
uniprot id: A0A4X1UYM7
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9823:HTR3A
gene id: 9823:HTR3A
uniprot id: A0A4X1T4H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:IL7R
gene id: 9823:IL7R
uniprot id: A0A8D1GNY7
uniprot id: B9ZSM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

9823:ENTPD7
gene id: 9823:ENTPD7
uniprot id: A0A8D1LB91
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9823:FAM46B
gene id: 9823:FAM46B
uniprot id: A0A4X1UN47
names: Similarity
messages: Belongs to the TENT family.

9823:SDE2
gene id: 9823:SDE2
uniprot id: A0A8D0THJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

9823:DCTN6
gene id: 9823:DCTN6
uniprot id: A0A4X1VN73
uniprot id: A0A8D0Y950
uniprot id: D0G6S1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
messages: Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.
messages: Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3 (PubMed:25814576, PubMed:29420470, PubMed:33734450, PubMed:36071160). The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. Within the complex DCTN6 forms a heterodimer with DCTN5 (PubMed:33734450). The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin (PubMed:25814576, PubMed:33734450, PubMed:36071160, PubMed:29420470). Interacts with PLK1 (By similarity).
messages: cytoskeleton
messages: kinetochore

9823:RPL19
gene id: 9823:RPL19
uniprot id: A0A8D0U758
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

9823:RIPK3
gene id: 9823:RIPK3
uniprot id: F1SGQ6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:EEF2K
gene id: 9823:EEF2K
uniprot id: A0A8D1ABQ6
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

9823:NAA38
gene id: 9823:NAA38
uniprot id: A0A480JI26
uniprot id: A0A8D1W328
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

9823:SMIM12
gene id: 9823:SMIM12
uniprot id: A0A4X1VZM1
uniprot id: A0A8W4FEK3
names: Similarity
messages: Belongs to the SMIM12 family.

9823:EXTL2
gene id: 9823:EXTL2
uniprot id: A0A4X1TSB0
uniprot id: A0A8D0VDC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:PPARGC1A
gene id: 9823:PPARGC1A
uniprot id: Q865B6
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Heavily acetylated by KAT2A/GCN5 under conditions of high nutrients, leading to inactivation of PPARGC1A. Deacetylated by SIRT1 in low nutrients/high NAD conditions, leading to its activation.
messages: Homooligomer (By similarity). Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation. Interacts with PRDM16, LPIN1 and PML. Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation (By similarity). Interacts with LRPPRC (By similarity). Interacts with FOXO1 (By similarity).
messages: Nucleus
messages: PML body
messages: Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.
messages: Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (By similarity). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity).
messages: Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.

9823:CPEB1
gene id: 9823:CPEB1
uniprot id: A4PES2
names: Similarity
messages: Belongs to the RRM CPEB family.

9823:ERAL1
gene id: 9823:ERAL1
uniprot id: A0A8D1CDW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

9823:INTS11
gene id: 9823:INTS11
uniprot id: A0A480SL68
uniprot id: A0A4X1WAC3
uniprot id: A0A8D1C103
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

9823:C7H6orf125
gene id: 9823:C7H6orf125
uniprot id: A0A287B747
uniprot id: A0A4X1T8G3
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9823:TNFRSF1A
gene id: 9823:TNFRSF1A
uniprot id: P50555
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BABAM2, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with DAB2IP. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway. Interacts with SH3RF2, TRADD and RIPK1. SH3RF2 facilitates the recruitment of RIPK1 and TRADD to TNFRSF1A in a TNF-alpha-dependent process. Interacts with PGLYRP1; this interaction is important for cell death induction. Interacts (via death domain) with MADD (via death domain) (By similarity).
messages: Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).

9823:HYAL3
gene id: 9823:HYAL3
uniprot id: A0A480XR39
uniprot id: A0A4X1SKF7
uniprot id: A0A4X1SLH4
uniprot id: A0A8D0KIN5
uniprot id: Q6RHW2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.
messages: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.
messages: Highly expressed in bladder, spleen and liver. Expressed at low levels in the kidney.
messages: Membrane
messages: N-glycosylated.
messages: Secreted
messages: acrosome

9823:EIF4EBP3
gene id: 9823:EIF4EBP3
uniprot id: A0A4X1SEI3
uniprot id: A0A8D1PHL4
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9823:ANAPC10
gene id: 9823:ANAPC10
uniprot id: A0A8D0Q8K0
uniprot id: D5L7X1
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9823:NPEPL1
gene id: 9823:NPEPL1
uniprot id: A0A480S777
uniprot id: A0A8D1A550
uniprot id: A5GFT5
names: Similarity
messages: Belongs to the peptidase M17 family.

9823:CCNYL1
gene id: 9823:CCNYL1
uniprot id: A0A4X1UYZ9
uniprot id: A0A4X1V0C9
uniprot id: A0A5G2QXE9
uniprot id: I3L5S3
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9823:ZNF197
gene id: 9823:ZNF197
uniprot id: A0A287AE44
uniprot id: A0A8D0ZWW6
names: Subcellular Location Annotation
messages: Nucleus

9823:ADAM9
gene id: 9823:ADAM9
uniprot id: A0A4X1VWW2
uniprot id: F1RZL4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CSN2
gene id: 9823:CSN2
uniprot id: B5KLC4
uniprot id: P39037
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-casein family.
messages: Important role in determination of the surface properties of the casein micelles.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9823:RPL13
gene id: 9823:RPL13
uniprot id: A0A4X1TCB0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

9823:RRAGD
gene id: 9823:RRAGD
uniprot id: A0A481CHT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9823:RNF13
gene id: 9823:RNF13
uniprot id: A0A287AZC7
uniprot id: A0A8D0J9P0
names: Subcellular Location Annotation
messages: Membrane

9823:SMC1A
gene id: 9823:SMC1A
uniprot id: A0A287B9V7
uniprot id: A0A4X1SXG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9823:SCAMP5
gene id: 9823:SCAMP5
uniprot id: A0A8D1WZ88
uniprot id: F1SJ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9823:AP1G1
gene id: 9823:AP1G1
uniprot id: A0A4X1SLQ9
uniprot id: A0A4X1SMZ1
uniprot id: A0A5K1VTT2
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9823:IL10RB
gene id: 9823:IL10RB
uniprot id: Q764M7
names: Subcellular Location Annotation
messages: Membrane

9823:TMEM80
gene id: 9823:TMEM80
uniprot id: A0A4X1W071
uniprot id: F1RYY4
names: Subcellular Location Annotation
messages: Membrane

9823:CYP1A2
gene id: 9823:CYP1A2
uniprot id: A0A4X1TKW5
uniprot id: F1SJ26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9823:MEGF8
gene id: 9823:MEGF8
uniprot id: A0A4X1SJD4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:LOC100522627
gene id: 9823:LOC100522627
uniprot id: F1RNG2
names: Subcellular Location Annotation
messages: Membrane

9823:ENO3
gene id: 9823:ENO3
uniprot id: B1A3A0
uniprot id: Q1KYT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Cytoplasm
messages: Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration.
messages: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific. Interacts with PNKD (By similarity).
messages: Mg(2+) is required for catalysis and for stabilizing the dimer.

9823:LOC102157846
gene id: 9823:LOC102157846
uniprot id: A0A5G2QL61
uniprot id: A0A8D1S3W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:IGF2
gene id: 9823:IGF2
uniprot id: G9BFT5
uniprot id: P23695
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Interacts with MYORG; this interaction is required for IGF2 secretion. Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.
messages: Secreted
messages: The IGF2 locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is imprinted, hence silenced.
messages: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).
messages: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate.

9823:C3H16orf72
gene id: 9823:C3H16orf72
uniprot id: A0A8D0NYF6
uniprot id: I3LPV6
names: Subcellular Location Annotation
messages: Nucleus

9823:CREG1
gene id: 9823:CREG1
uniprot id: A0A4X1VB53
uniprot id: A0A4X1VB58
uniprot id: F1S268
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9823:NMUR1
gene id: 9823:NMUR1
uniprot id: A0A060IQ50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9823:NAP1L3
gene id: 9823:NAP1L3
uniprot id: A0A8W4F809
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9823:NOL6
gene id: 9823:NOL6
uniprot id: A0A8D0SPK7
uniprot id: F1SE91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: nucleolus

9823:NFYB
gene id: 9823:NFYB
uniprot id: A0A4X1T8K5
uniprot id: A0A8D1Y8I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9823:GPC3
gene id: 9823:GPC3
uniprot id: A0A8D1DTY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9823:TAF15
gene id: 9823:TAF15
uniprot id: A0A8D2BCE6
uniprot id: A0A8X9AEW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9823:CDKN3
gene id: 9823:CDKN3
uniprot id: Q9MYN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity (By similarity).
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity).
messages: perinuclear region

9823:EPHX1
gene id: 9823:EPHX1
uniprot id: A0A480XW48
uniprot id: P79381
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity).
messages: Endoplasmic reticulum membrane
messages: Inhibited by 10-hydroxystearamide and methoxy-arachidonyl fluorophosphate.
messages: Microsome membrane

9823:CPPED1
gene id: 9823:CPPED1
uniprot id: A0A5G2QI52
uniprot id: A0A8D1QU30
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

9823:WNT1
gene id: 9823:WNT1
uniprot id: A0A4X1WCQ6
uniprot id: F1SJ15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:LOC396905
gene id: 9823:LOC396905
uniprot id: P26461
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Inhibits acrosin.
messages: Secreted
messages: Seminal plasma.

9823:SLC6A12
gene id: 9823:SLC6A12
uniprot id: A0A8D1Y8Y2
uniprot id: F1SK80
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Cell membrane
messages: Interacts with LIN7C.
messages: Lateral cell membrane
messages: Membrane