96561:DOLE RS07070
gene id: 96561:DOLE_RS07070
uniprot id: A8ZYS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

96561:DOLE RS06610
gene id: 96561:DOLE_RS06610
uniprot id: A8ZY89
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

96561:DOLE RS00795
gene id: 96561:DOLE_RS00795
uniprot id: A8ZSQ6
names: Similarity
messages: Belongs to the universal stress protein A family.

96561:DOLE RS07265
gene id: 96561:DOLE_RS07265
uniprot id: A8ZYW3
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

96561:DOLE RS16320
gene id: 96561:DOLE_RS16320
uniprot id: A9A056
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

96561:DOLE RS01565
gene id: 96561:DOLE_RS01565
uniprot id: A8ZSV7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

96561:DOLE RS05730
gene id: 96561:DOLE_RS05730
uniprot id: A8ZXG7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

96561:DOLE RS08915
gene id: 96561:DOLE_RS08915
uniprot id: A9A0R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

96561:DOLE RS03080
gene id: 96561:DOLE_RS03080
uniprot id: A8ZUA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

96561:DOLE RS12600
gene id: 96561:DOLE_RS12600
uniprot id: A8ZW27
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

96561:DOLE RS00120
gene id: 96561:DOLE_RS00120
uniprot id: A8ZRR7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

96561:DOLE RS03715
gene id: 96561:DOLE_RS03715
uniprot id: A8ZV69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

96561:DOLE RS06570
gene id: 96561:DOLE_RS06570
uniprot id: A8ZY81
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

96561:DOLE RS16590
gene id: 96561:DOLE_RS16590
uniprot id: A9A0A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

96561:DOLE RS02730
gene id: 96561:DOLE_RS02730
uniprot id: A8ZU36
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

96561:DOLE RS03470
gene id: 96561:DOLE_RS03470
uniprot id: A8ZUS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

96561:DOLE RS02395
gene id: 96561:DOLE_RS02395
uniprot id: A8ZTM0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

96561:DOLE RS15720
gene id: 96561:DOLE_RS15720
uniprot id: A8ZZI4
names: Similarity
messages: Belongs to the GSP E family.

96561:DOLE RS03860
gene id: 96561:DOLE_RS03860
uniprot id: A8ZV98
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

96561:DOLE RS06015
gene id: 96561:DOLE_RS06015
uniprot id: A8ZXM2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

96561:DOLE RS05370
gene id: 96561:DOLE_RS05370
uniprot id: A8ZWZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Cell membrane
messages: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

96561:DOLE RS05635
gene id: 96561:DOLE_RS05635
uniprot id: A8ZX50
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

96561:DOLE RS01380
gene id: 96561:DOLE_RS01380
uniprot id: A8ZS69
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

96561:DOLE RS00455
gene id: 96561:DOLE_RS00455
uniprot id: A8ZRY4
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

96561:DOLE RS02435
gene id: 96561:DOLE_RS02435
uniprot id: A8ZTM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

96561:DOLE RS15340
gene id: 96561:DOLE_RS15340
uniprot id: A8ZZ11
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

96561:DOLE RS00445
gene id: 96561:DOLE_RS00445
uniprot id: A8ZRY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

96561:DOLE RS08310
gene id: 96561:DOLE_RS08310
uniprot id: A9A021
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

96561:DOLE RS13095
gene id: 96561:DOLE_RS13095
uniprot id: A8ZWM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

96561:DOLE RS14590
gene id: 96561:DOLE_RS14590
uniprot id: A8ZY11
names: Similarity
messages: Belongs to the LOG family.

96561:DOLE RS03730
gene id: 96561:DOLE_RS03730
uniprot id: A8ZV72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

96561:DOLE RS12465
gene id: 96561:DOLE_RS12465
uniprot id: A8ZVP7
names: Caution
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS04215
gene id: 96561:DOLE_RS04215
uniprot id: A8ZVR9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS16630
gene id: 96561:DOLE_RS16630
uniprot id: A9A0B6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

96561:DOLE RS14150
gene id: 96561:DOLE_RS14150
uniprot id: A8ZXT0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

96561:DOLE RS08920
gene id: 96561:DOLE_RS08920
uniprot id: A9A0R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

96561:DOLE RS04375
gene id: 96561:DOLE_RS04375
uniprot id: A8ZVV0
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

96561:DOLE RS03825
gene id: 96561:DOLE_RS03825
uniprot id: A8ZV91
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

96561:DOLE RS02385
gene id: 96561:DOLE_RS02385
uniprot id: A8ZTL8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

96561:DOLE RS01175
gene id: 96561:DOLE_RS01175
uniprot id: A8ZS28
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

96561:DOLE RS03230
gene id: 96561:DOLE_RS03230
uniprot id: A8ZUM6
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS05725
gene id: 96561:DOLE_RS05725
uniprot id: A8ZXG6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

96561:DOLE RS08505
gene id: 96561:DOLE_RS08505
uniprot id: A9A0G0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

96561:DOLE RS07750
gene id: 96561:DOLE_RS07750
uniprot id: A8ZZF7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

96561:DOLE RS06565
gene id: 96561:DOLE_RS06565
uniprot id: A8ZY80
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS14665
gene id: 96561:DOLE_RS14665
uniprot id: A8ZYC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

96561:DOLE RS04750
gene id: 96561:DOLE_RS04750
uniprot id: A8ZWC5
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

96561:DOLE RS03655
gene id: 96561:DOLE_RS03655
uniprot id: A8ZV57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

96561:DOLE RS04970
gene id: 96561:DOLE_RS04970
uniprot id: A8ZWG8
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

96561:DOLE RS03660
gene id: 96561:DOLE_RS03660
uniprot id: A8ZV58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

96561:DOLE RS07370
gene id: 96561:DOLE_RS07370
uniprot id: A8ZZ83
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS10670
gene id: 96561:DOLE_RS10670
uniprot id: A8ZTU6
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

96561:DOLE RS14345
gene id: 96561:DOLE_RS14345
uniprot id: A8ZXW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

96561:DOLE RS02700
gene id: 96561:DOLE_RS02700
uniprot id: A8ZU30
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS17470
gene id: 96561:DOLE_RS17470
uniprot id: A8ZTW4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

96561:DOLE RS07805
gene id: 96561:DOLE_RS07805
uniprot id: A8ZZG8
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

96561:DOLE RS05275
gene id: 96561:DOLE_RS05275
uniprot id: A8ZWY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

96561:DOLE RS16625
gene id: 96561:DOLE_RS16625
uniprot id: A9A0B5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

96561:DOLE RS03830
gene id: 96561:DOLE_RS03830
uniprot id: A8ZV92
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

96561:DOLE RS01560
gene id: 96561:DOLE_RS01560
uniprot id: A8ZSV6
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS04930
gene id: 96561:DOLE_RS04930
uniprot id: A8ZWG0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

96561:DOLE RS15330
gene id: 96561:DOLE_RS15330
uniprot id: A8ZZ09
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

96561:DOLE RS09920
gene id: 96561:DOLE_RS09920
uniprot id: A8ZT56
names: Similarity
messages: Belongs to the Nudix hydrolase family.

96561:DOLE RS09605
gene id: 96561:DOLE_RS09605
uniprot id: A8ZSD5
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS16310
gene id: 96561:DOLE_RS16310
uniprot id: A9A054
names: Cofactor
messages: Binds 4 heme c groups covalently per monomer.

96561:DOLE RS08560
gene id: 96561:DOLE_RS08560
uniprot id: A9A0H1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

96561:DOLE RS11400
gene id: 96561:DOLE_RS11400
uniprot id: A8ZUI9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

96561:DOLE RS00025
gene id: 96561:DOLE_RS00025
uniprot id: A8ZRP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

96561:DOLE RS16660
gene id: 96561:DOLE_RS16660
uniprot id: A9A0C2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

96561:DOLE RS13715
gene id: 96561:DOLE_RS13715
uniprot id: A8ZX96
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

96561:DOLE RS16950
gene id: 96561:DOLE_RS16950
uniprot id: A8ZTN2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS03685
gene id: 96561:DOLE_RS03685
uniprot id: A8ZV63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

96561:DOLE RS03040
gene id: 96561:DOLE_RS03040
uniprot id: A8ZU94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

96561:DOLE RS09070
gene id: 96561:DOLE_RS09070
uniprot id: A9A0U3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

96561:DOLE RS08200
gene id: 96561:DOLE_RS08200
uniprot id: A8ZZZ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

96561:DOLE RS14905
gene id: 96561:DOLE_RS14905
uniprot id: A8ZYH5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase A1 family.
messages: Binds 1 Ca(2+) ion per monomer.
messages: Cell outer membrane
messages: Homodimer; dimerization is reversible, and the dimeric form is the active one.
messages: Membrane

96561:DOLE RS06330
gene id: 96561:DOLE_RS06330
uniprot id: A8ZY34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

96561:DOLE RS14330
gene id: 96561:DOLE_RS14330
uniprot id: A8ZXW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

96561:DOLE RS02805
gene id: 96561:DOLE_RS02805
uniprot id: A8ZU49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

96561:DOLE RS05135
gene id: 96561:DOLE_RS05135
uniprot id: A8ZWK1
names: Similarity
messages: Belongs to the HdrA family.

96561:DOLE RS09830
gene id: 96561:DOLE_RS09830
uniprot id: A8ZSI4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

96561:DOLE RS05695
gene id: 96561:DOLE_RS05695
uniprot id: A8ZX62
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

96561:DOLE RS10920
gene id: 96561:DOLE_RS10920
uniprot id: A8ZTZ6
names: Similarity
messages: Belongs to the pyruvate kinase family.

96561:DOLE RS11455
gene id: 96561:DOLE_RS11455
uniprot id: A8ZUK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

96561:DOLE RS00470
gene id: 96561:DOLE_RS00470
uniprot id: A8ZRY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

96561:DOLE RS14015
gene id: 96561:DOLE_RS14015
uniprot id: A8ZXF0
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

96561:DOLE RS17450
gene id: 96561:DOLE_RS17450
uniprot id: A8ZTC1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

96561:DOLE RS01965
gene id: 96561:DOLE_RS01965
uniprot id: A8ZT36
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS12735
gene id: 96561:DOLE_RS12735
uniprot id: A8ZW51
names: Similarity
messages: Belongs to the ClpA/ClpB family.

96561:DOLE RS15625
gene id: 96561:DOLE_RS15625
uniprot id: A8ZZ67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

96561:DOLE RS15860
gene id: 96561:DOLE_RS15860
uniprot id: A8ZZL2
names: Similarity
messages: Belongs to the universal stress protein A family.

96561:DOLE RS10850
gene id: 96561:DOLE_RS10850
uniprot id: A8ZTY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS17175
gene id: 96561:DOLE_RS17175
uniprot id: A8ZY77
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.
messages: Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).

96561:DOLE RS08150
gene id: 96561:DOLE_RS08150
uniprot id: A8ZZY9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

96561:DOLE RS11620
gene id: 96561:DOLE_RS11620
uniprot id: A8ZUX4
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

96561:DOLE RS03515
gene id: 96561:DOLE_RS03515
uniprot id: A8ZUT0
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

96561:DOLE RS07680
gene id: 96561:DOLE_RS07680
uniprot id: A8ZZE4
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

96561:DOLE RS07875
gene id: 96561:DOLE_RS07875
uniprot id: A8ZZT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell inner membrane
messages: Probably functions as a manganese efflux pump.

96561:DOLE RS04585
gene id: 96561:DOLE_RS04585
uniprot id: A8ZVZ2
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

96561:DOLE RS05185
gene id: 96561:DOLE_RS05185
uniprot id: A8ZWL1
names: Similarity
messages: Belongs to the polysaccharide synthase family.

96561:DOLE RS10675
gene id: 96561:DOLE_RS10675
uniprot id: A8ZTU7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

96561:DOLE RS01020
gene id: 96561:DOLE_RS01020
uniprot id: A8ZSV0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS09505
gene id: 96561:DOLE_RS09505
uniprot id: A8ZSB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

96561:DOLE RS12275
gene id: 96561:DOLE_RS12275
uniprot id: A8ZVL0
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

96561:DOLE RS09060
gene id: 96561:DOLE_RS09060
uniprot id: A9A0U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

96561:DOLE RS14630
gene id: 96561:DOLE_RS14630
uniprot id: A8ZYC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

96561:DOLE RS17365
gene id: 96561:DOLE_RS17365
uniprot id: A9A0X6
names: Similarity
messages: Belongs to the CapA family.

96561:DOLE RS02885
gene id: 96561:DOLE_RS02885
uniprot id: A8ZU65
names: Activity Regulation
names: Caution
names: Domain
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

96561:DOLE RS10470
gene id: 96561:DOLE_RS10470
uniprot id: A8ZTQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

96561:DOLE RS02095
gene id: 96561:DOLE_RS02095
uniprot id: A8ZTG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

96561:DOLE RS14265
gene id: 96561:DOLE_RS14265
uniprot id: A8ZXV0
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

96561:DOLE RS00070
gene id: 96561:DOLE_RS00070
uniprot id: A8ZRQ7
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS08820
gene id: 96561:DOLE_RS08820
uniprot id: A9A0M0
names: Similarity
messages: Belongs to the acylphosphatase family.

96561:DOLE RS06160
gene id: 96561:DOLE_RS06160
uniprot id: A8ZXQ0
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

96561:DOLE RS06030
gene id: 96561:DOLE_RS06030
uniprot id: A8ZXM5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

96561:DOLE RS14240
gene id: 96561:DOLE_RS14240
uniprot id: A8ZXU5
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

96561:DOLE RS14080
gene id: 96561:DOLE_RS14080
uniprot id: A8ZXG2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

96561:DOLE RS02590
gene id: 96561:DOLE_RS02590
uniprot id: A8ZU09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

96561:DOLE RS03930
gene id: 96561:DOLE_RS03930
uniprot id: A8ZVB2
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS11665
gene id: 96561:DOLE_RS11665
uniprot id: A8ZUY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

96561:DOLE RS00225
gene id: 96561:DOLE_RS00225
uniprot id: A8ZRT7
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS12440
gene id: 96561:DOLE_RS12440
uniprot id: A8ZVP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.

96561:DOLE RS08765
gene id: 96561:DOLE_RS08765
uniprot id: A9A0K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

96561:DOLE RS08800
gene id: 96561:DOLE_RS08800
uniprot id: A9A0L6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

96561:DOLE RS03105
gene id: 96561:DOLE_RS03105
uniprot id: A8ZUK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS05250
gene id: 96561:DOLE_RS05250
uniprot id: A8ZWX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

96561:DOLE RS06040
gene id: 96561:DOLE_RS06040
uniprot id: A8ZXM7
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

96561:DOLE RS14325
gene id: 96561:DOLE_RS14325
uniprot id: A8ZXW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

96561:DOLE RS15615
gene id: 96561:DOLE_RS15615
uniprot id: A8ZZ65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

96561:DOLE RS15490
gene id: 96561:DOLE_RS15490
uniprot id: A8ZZ40
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS08870
gene id: 96561:DOLE_RS08870
uniprot id: A9A0N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

96561:DOLE RS06425
gene id: 96561:DOLE_RS06425
uniprot id: A8ZY52
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS04175
gene id: 96561:DOLE_RS04175
uniprot id: A8ZVR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

96561:DOLE RS06865
gene id: 96561:DOLE_RS06865
uniprot id: A8ZYN7
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS09360
gene id: 96561:DOLE_RS09360
uniprot id: A9A100
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

96561:DOLE RS08545
gene id: 96561:DOLE_RS08545
uniprot id: A9A0G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

96561:DOLE RS14545
gene id: 96561:DOLE_RS14545
uniprot id: A8ZY02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

96561:DOLE RS13865
gene id: 96561:DOLE_RS13865
uniprot id: A8ZXC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

96561:DOLE RS03725
gene id: 96561:DOLE_RS03725
uniprot id: A8ZV71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

96561:DOLE RS14755
gene id: 96561:DOLE_RS14755
uniprot id: A8ZYE4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

96561:DOLE RS02380
gene id: 96561:DOLE_RS02380
uniprot id: A8ZTL7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

96561:DOLE RS05155
gene id: 96561:DOLE_RS05155
uniprot id: A8ZWK5
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

96561:DOLE RS08370
gene id: 96561:DOLE_RS08370
uniprot id: A9A0D3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

96561:DOLE RS06970
gene id: 96561:DOLE_RS06970
uniprot id: A8ZYQ8
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS11685
gene id: 96561:DOLE_RS11685
uniprot id: A8ZUY7
names: Similarity
messages: Belongs to the glutamine synthetase family.

96561:DOLE RS12785
gene id: 96561:DOLE_RS12785
uniprot id: A8ZW61
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

96561:DOLE RS15020
gene id: 96561:DOLE_RS15020
uniprot id: A8ZYJ7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

96561:DOLE RS04860
gene id: 96561:DOLE_RS04860
uniprot id: A8ZWE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

96561:DOLE RS08880
gene id: 96561:DOLE_RS08880
uniprot id: A9A0N2
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

96561:DOLE RS08825
gene id: 96561:DOLE_RS08825
uniprot id: A9A0M1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

96561:DOLE RS09915
gene id: 96561:DOLE_RS09915
uniprot id: A8ZT55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

96561:DOLE RS07690
gene id: 96561:DOLE_RS07690
uniprot id: A8ZZE6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

96561:DOLE RS13200
gene id: 96561:DOLE_RS13200
uniprot id: A8ZWP5
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

96561:DOLE RS14390
gene id: 96561:DOLE_RS14390
uniprot id: A8ZXX4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

96561:DOLE RS15620
gene id: 96561:DOLE_RS15620
uniprot id: A8ZZ66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

96561:DOLE RS16325
gene id: 96561:DOLE_RS16325
uniprot id: A9A057
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

96561:DOLE RS03605
gene id: 96561:DOLE_RS03605
uniprot id: A8ZUU5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

96561:DOLE RS14425
gene id: 96561:DOLE_RS14425
uniprot id: A8ZXX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS09805
gene id: 96561:DOLE_RS09805
uniprot id: A8ZSH8
names: Similarity
messages: Belongs to the RemA family.

96561:DOLE RS11340
gene id: 96561:DOLE_RS11340
uniprot id: A8ZUH8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

96561:DOLE RS01780
gene id: 96561:DOLE_RS01780
uniprot id: A8ZSZ9
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS05490
gene id: 96561:DOLE_RS05490
uniprot id: A8ZX23
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

96561:DOLE RS01710
gene id: 96561:DOLE_RS01710
uniprot id: A8ZSY5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

96561:DOLE RS10260
gene id: 96561:DOLE_RS10260
uniprot id: A8ZTC2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS02525
gene id: 96561:DOLE_RS02525
uniprot id: A8ZTP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

96561:DOLE RS03775
gene id: 96561:DOLE_RS03775
uniprot id: A8ZV81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

96561:DOLE RS11125
gene id: 96561:DOLE_RS11125
uniprot id: A8ZUD6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS10710
gene id: 96561:DOLE_RS10710
uniprot id: A8ZTV4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

96561:DOLE RS00035
gene id: 96561:DOLE_RS00035
uniprot id: A8ZRQ0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

96561:DOLE RS13000
gene id: 96561:DOLE_RS13000
uniprot id: A8ZWA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

96561:DOLE RS01065
gene id: 96561:DOLE_RS01065
uniprot id: A8ZS05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

96561:DOLE RS12545
gene id: 96561:DOLE_RS12545
uniprot id: A8ZW16
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS01955
gene id: 96561:DOLE_RS01955
uniprot id: A8ZT34
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

96561:DOLE RS11825
gene id: 96561:DOLE_RS11825
uniprot id: A8ZV15
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

96561:DOLE RS01655
gene id: 96561:DOLE_RS01655
uniprot id: A8ZSX4
names: Similarity
messages: Belongs to the intimin/invasin family.

96561:DOLE RS01240
gene id: 96561:DOLE_RS01240
uniprot id: A8ZS41
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

96561:DOLE RS04020
gene id: 96561:DOLE_RS04020
uniprot id: A8ZVC9
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS13040
gene id: 96561:DOLE_RS13040
uniprot id: A8ZWL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

96561:DOLE RS02330
gene id: 96561:DOLE_RS02330
uniprot id: A8ZTK8
names: Cofactor
messages: Binds 4 heme c groups covalently per monomer.

96561:DOLE RS11505
gene id: 96561:DOLE_RS11505
uniprot id: A8ZUV1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

96561:DOLE RS13085
gene id: 96561:DOLE_RS13085
uniprot id: A8ZWM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

96561:DOLE RS00350
gene id: 96561:DOLE_RS00350
uniprot id: A8ZRW3
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

96561:DOLE RS09310
gene id: 96561:DOLE_RS09310
uniprot id: A9A0Z1
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

96561:DOLE RS07785
gene id: 96561:DOLE_RS07785
uniprot id: A8ZZG4
names: Similarity
messages: Belongs to the thioredoxin family.

96561:DOLE RS08485
gene id: 96561:DOLE_RS08485
uniprot id: A9A0F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

96561:DOLE RS10575
gene id: 96561:DOLE_RS10575
uniprot id: A8ZTS8
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

96561:DOLE RS13055
gene id: 96561:DOLE_RS13055
uniprot id: A8ZWL6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

96561:DOLE RS13105
gene id: 96561:DOLE_RS13105
uniprot id: A8ZWM7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

96561:DOLE RS11370
gene id: 96561:DOLE_RS11370
uniprot id: A8ZUI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

96561:DOLE RS05720
gene id: 96561:DOLE_RS05720
uniprot id: A8ZXG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

96561:DOLE RS03650
gene id: 96561:DOLE_RS03650
uniprot id: A8ZV56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

96561:DOLE RS04145
gene id: 96561:DOLE_RS04145
uniprot id: A8ZVQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

96561:DOLE RS11840
gene id: 96561:DOLE_RS11840
uniprot id: A8ZV18
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

96561:DOLE RS11105
gene id: 96561:DOLE_RS11105
uniprot id: A8ZUD2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

96561:DOLE RS14680
gene id: 96561:DOLE_RS14680
uniprot id: A8ZYD0
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

96561:DOLE RS10570
gene id: 96561:DOLE_RS10570
uniprot id: A8ZTS7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

96561:DOLE RS09560
gene id: 96561:DOLE_RS09560
uniprot id: A8ZSC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

96561:DOLE RS11285
gene id: 96561:DOLE_RS11285
uniprot id: A8ZUG7
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

96561:DOLE RS03240
gene id: 96561:DOLE_RS03240
uniprot id: A8ZUM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.

96561:DOLE RS06275
gene id: 96561:DOLE_RS06275
uniprot id: A8ZY23
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

96561:DOLE RS16480
gene id: 96561:DOLE_RS16480
uniprot id: A9A088
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS06500
gene id: 96561:DOLE_RS06500
uniprot id: A8ZY67
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

96561:DOLE RS11225
gene id: 96561:DOLE_RS11225
uniprot id: A8ZUF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

96561:DOLE RS10085
gene id: 96561:DOLE_RS10085
uniprot id: A8ZT87
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS10845
gene id: 96561:DOLE_RS10845
uniprot id: A8ZTY1
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

96561:DOLE RS00600
gene id: 96561:DOLE_RS00600
uniprot id: A8ZSL8
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS09565
gene id: 96561:DOLE_RS09565
uniprot id: A8ZSC7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS11435
gene id: 96561:DOLE_RS11435
uniprot id: A8ZUJ6
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

96561:DOLE RS11135
gene id: 96561:DOLE_RS11135
uniprot id: A8ZUD8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

96561:DOLE RS17615
gene id: 96561:DOLE_RS17615
uniprot id: A8ZY07
names: Cofactor
messages: Binds 4 heme c groups covalently per monomer.

96561:DOLE RS14350
gene id: 96561:DOLE_RS14350
uniprot id: A8ZXW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

96561:DOLE RS09615
gene id: 96561:DOLE_RS09615
uniprot id: A8ZSD7
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.

96561:DOLE RS02350
gene id: 96561:DOLE_RS02350
uniprot id: A8ZTL2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS02800
gene id: 96561:DOLE_RS02800
uniprot id: A8ZU48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

96561:DOLE RS09510
gene id: 96561:DOLE_RS09510
uniprot id: A8ZSB7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

96561:DOLE RS00065
gene id: 96561:DOLE_RS00065
uniprot id: A8ZRQ6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

96561:DOLE RS02600
gene id: 96561:DOLE_RS02600
uniprot id: A8ZU11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

96561:DOLE RS09665
gene id: 96561:DOLE_RS09665
uniprot id: A8ZSE7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

96561:DOLE RS02225
gene id: 96561:DOLE_RS02225
uniprot id: A8ZTI6
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

96561:DOLE RS14505
gene id: 96561:DOLE_RS14505
uniprot id: A8ZXZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

96561:DOLE RS10465
gene id: 96561:DOLE_RS10465
uniprot id: A8ZTQ8
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

96561:DOLE RS00315
gene id: 96561:DOLE_RS00315
uniprot id: A8ZRV6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

96561:DOLE RS14720
gene id: 96561:DOLE_RS14720
uniprot id: A8ZYD7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

96561:DOLE RS03450
gene id: 96561:DOLE_RS03450
uniprot id: A8ZUR6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS09990
gene id: 96561:DOLE_RS09990
uniprot id: A8ZT68
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

96561:DOLE RS04030
gene id: 96561:DOLE_RS04030
uniprot id: A8ZVD1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

96561:DOLE RS12100
gene id: 96561:DOLE_RS12100
uniprot id: A8ZVH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

96561:DOLE RS04130
gene id: 96561:DOLE_RS04130
uniprot id: A8ZVF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

96561:DOLE RS17745
gene id: 96561:DOLE_RS17745
uniprot id: A9A0Q3
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS00750
gene id: 96561:DOLE_RS00750
uniprot id: A8ZSP9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

96561:DOLE RS08555
gene id: 96561:DOLE_RS08555
uniprot id: A9A0H0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

96561:DOLE RS02235
gene id: 96561:DOLE_RS02235
uniprot id: A8ZTI8
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

96561:DOLE RS05735
gene id: 96561:DOLE_RS05735
uniprot id: A8ZXG8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS10700
gene id: 96561:DOLE_RS10700
uniprot id: A8ZTV2
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

96561:DOLE RS02550
gene id: 96561:DOLE_RS02550
uniprot id: A8ZTP9
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

96561:DOLE RS14840
gene id: 96561:DOLE_RS14840
uniprot id: A8ZYG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

96561:DOLE RS08075
gene id: 96561:DOLE_RS08075
uniprot id: A8ZZX4
names: Similarity
messages: Belongs to the CinA family.

96561:DOLE RS05030
gene id: 96561:DOLE_RS05030
uniprot id: A8ZWI0
names: Similarity
messages: Belongs to the NodU/CmcH family.

96561:DOLE RS16685
gene id: 96561:DOLE_RS16685
uniprot id: A9A0C7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

96561:DOLE RS08860
gene id: 96561:DOLE_RS08860
uniprot id: A9A0M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

96561:DOLE RS03645
gene id: 96561:DOLE_RS03645
uniprot id: A8ZUU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

96561:DOLE RS02115
gene id: 96561:DOLE_RS02115
uniprot id: A8ZTG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

96561:DOLE RS13835
gene id: 96561:DOLE_RS13835
uniprot id: A8ZXB8
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

96561:DOLE RS10440
gene id: 96561:DOLE_RS10440
uniprot id: A8ZTQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

96561:DOLE RS11300
gene id: 96561:DOLE_RS11300
uniprot id: A8ZUH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

96561:DOLE RS05770
gene id: 96561:DOLE_RS05770
uniprot id: A8ZXH5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

96561:DOLE RS00475
gene id: 96561:DOLE_RS00475
uniprot id: A8ZRY8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

96561:DOLE RS04865
gene id: 96561:DOLE_RS04865
uniprot id: A8ZWE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

96561:DOLE RS08595
gene id: 96561:DOLE_RS08595
uniprot id: A9A0H8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

96561:DOLE RS10825
gene id: 96561:DOLE_RS10825
uniprot id: A8ZTX7
names: Similarity
messages: Belongs to the RecJ family.

96561:DOLE RS09780
gene id: 96561:DOLE_RS09780
uniprot id: A8ZSH3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

96561:DOLE RS03255
gene id: 96561:DOLE_RS03255
uniprot id: A8ZUN0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

96561:DOLE RS08385
gene id: 96561:DOLE_RS08385
uniprot id: A9A0D6
names: Similarity
messages: Belongs to the ParB family.

96561:DOLE RS07525
gene id: 96561:DOLE_RS07525
uniprot id: A8ZZB3
names: Similarity
messages: Belongs to the asparagine synthetase family.

96561:DOLE RS13575
gene id: 96561:DOLE_RS13575
uniprot id: A8ZX68
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

96561:DOLE RS14805
gene id: 96561:DOLE_RS14805
uniprot id: A8ZYF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

96561:DOLE RS04220
gene id: 96561:DOLE_RS04220
uniprot id: A8ZVS0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS12755
gene id: 96561:DOLE_RS12755
uniprot id: A8ZW55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

96561:DOLE RS14120
gene id: 96561:DOLE_RS14120
uniprot id: A8ZXS2
names: Similarity
messages: Belongs to the threonine synthase family.

96561:DOLE RS09645
gene id: 96561:DOLE_RS09645
uniprot id: A8ZSE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

96561:DOLE RS16605
gene id: 96561:DOLE_RS16605
uniprot id: A9A0B1
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS00390
gene id: 96561:DOLE_RS00390
uniprot id: A8ZRX1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

96561:DOLE RS02430
gene id: 96561:DOLE_RS02430
uniprot id: A8ZTM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

96561:DOLE RS06495
gene id: 96561:DOLE_RS06495
uniprot id: A8ZY66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

96561:DOLE RS06540
gene id: 96561:DOLE_RS06540
uniprot id: A8ZY75
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

96561:DOLE RS08785
gene id: 96561:DOLE_RS08785
uniprot id: A9A0L3
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

96561:DOLE RS13505
gene id: 96561:DOLE_RS13505
uniprot id: A8ZWV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

96561:DOLE RS15355
gene id: 96561:DOLE_RS15355
uniprot id: A8ZZ13
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

96561:DOLE RS15510
gene id: 96561:DOLE_RS15510
uniprot id: A8ZZ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS00515
gene id: 96561:DOLE_RS00515
uniprot id: A8ZSK1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS06950
gene id: 96561:DOLE_RS06950
uniprot id: A8ZYQ4
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

96561:DOLE RS03705
gene id: 96561:DOLE_RS03705
uniprot id: A8ZV67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

96561:DOLE RS14245
gene id: 96561:DOLE_RS14245
uniprot id: A8ZXU6
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

96561:DOLE RS08405
gene id: 96561:DOLE_RS08405
uniprot id: A9A0E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

96561:DOLE RS03765
gene id: 96561:DOLE_RS03765
uniprot id: A8ZV79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

96561:DOLE RS01455
gene id: 96561:DOLE_RS01455
uniprot id: A8ZS82
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

96561:DOLE RS04320
gene id: 96561:DOLE_RS04320
uniprot id: A8ZVT9
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

96561:DOLE RS12590
gene id: 96561:DOLE_RS12590
uniprot id: A8ZW25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

96561:DOLE RS17350
gene id: 96561:DOLE_RS17350
uniprot id: A9A0U4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

96561:DOLE RS02045
gene id: 96561:DOLE_RS02045
uniprot id: A8ZT53
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

96561:DOLE RS15060
gene id: 96561:DOLE_RS15060
uniprot id: A8ZYK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

96561:DOLE RS12155
gene id: 96561:DOLE_RS12155
uniprot id: A8ZVI6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

96561:DOLE RS02390
gene id: 96561:DOLE_RS02390
uniprot id: A8ZTL9
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

96561:DOLE RS07480
gene id: 96561:DOLE_RS07480
uniprot id: A8ZZA4
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

96561:DOLE RS10680
gene id: 96561:DOLE_RS10680
uniprot id: A8ZTU8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS12305
gene id: 96561:DOLE_RS12305
uniprot id: A8ZVL6
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS14340
gene id: 96561:DOLE_RS14340
uniprot id: A8ZXW4
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS07810
gene id: 96561:DOLE_RS07810
uniprot id: A8ZZG9
names: Similarity
messages: Belongs to the lipase chaperone family.

96561:DOLE RS04490
gene id: 96561:DOLE_RS04490
uniprot id: A8ZVX3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

96561:DOLE RS08215
gene id: 96561:DOLE_RS08215
uniprot id: A9A002
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

96561:DOLE RS03610
gene id: 96561:DOLE_RS03610
uniprot id: A8ZUU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

96561:DOLE RS05800
gene id: 96561:DOLE_RS05800
uniprot id: A8ZXI1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

96561:DOLE RS12760
gene id: 96561:DOLE_RS12760
uniprot id: A8ZW56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

96561:DOLE RS14070
gene id: 96561:DOLE_RS14070
uniprot id: A8ZXG0
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

96561:DOLE RS11385
gene id: 96561:DOLE_RS11385
uniprot id: A8ZUI7
names: Similarity
messages: Belongs to the LarC family.

96561:DOLE RS08145
gene id: 96561:DOLE_RS08145
uniprot id: A8ZZY8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

96561:DOLE RS16900
gene id: 96561:DOLE_RS16900
uniprot id: A8ZSR5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

96561:DOLE RS01545
gene id: 96561:DOLE_RS01545
uniprot id: A8ZSV3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

96561:DOLE RS08005
gene id: 96561:DOLE_RS08005
uniprot id: A8ZZW1
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

96561:DOLE RS11730
gene id: 96561:DOLE_RS11730
uniprot id: A8ZUZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

96561:DOLE RS16510
gene id: 96561:DOLE_RS16510
uniprot id: A9A093
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

96561:DOLE RS02360
gene id: 96561:DOLE_RS02360
uniprot id: A8ZTL3
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

96561:DOLE RS00640
gene id: 96561:DOLE_RS00640
uniprot id: A8ZSM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

96561:DOLE RS15930
gene id: 96561:DOLE_RS15930
uniprot id: A8ZZM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS06920
gene id: 96561:DOLE_RS06920
uniprot id: A8ZYP8
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS15345
gene id: 96561:DOLE_RS15345
uniprot id: A8ZZ12
names: Similarity
messages: Belongs to the heat shock protein 70 family.

96561:DOLE RS14115
gene id: 96561:DOLE_RS14115
uniprot id: A8ZXS1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

96561:DOLE RS10690
gene id: 96561:DOLE_RS10690
uniprot id: A8ZTV0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

96561:DOLE RS06520
gene id: 96561:DOLE_RS06520
uniprot id: A8ZY71
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

96561:DOLE RS14315
gene id: 96561:DOLE_RS14315
uniprot id: A8ZXV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

96561:DOLE RS11200
gene id: 96561:DOLE_RS11200
uniprot id: A8ZUF1
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

96561:DOLE RS06940
gene id: 96561:DOLE_RS06940
uniprot id: A8ZYQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

96561:DOLE RS05560
gene id: 96561:DOLE_RS05560
uniprot id: A8ZX35
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

96561:DOLE RS16335
gene id: 96561:DOLE_RS16335
uniprot id: A9A059
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

96561:DOLE RS10860
gene id: 96561:DOLE_RS10860
uniprot id: A8ZTY4
names: Cofactor
names: Similarity
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

96561:DOLE RS07780
gene id: 96561:DOLE_RS07780
uniprot id: A8ZZG3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

96561:DOLE RS14935
gene id: 96561:DOLE_RS14935
uniprot id: A8ZYI1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS00735
gene id: 96561:DOLE_RS00735
uniprot id: A8ZSP6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

96561:DOLE RS12530
gene id: 96561:DOLE_RS12530
uniprot id: A8ZW13
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

96561:DOLE RS11245
gene id: 96561:DOLE_RS11245
uniprot id: A8ZUG0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IcmF family.
messages: Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
messages: Homodimer.
messages: Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS07725
gene id: 96561:DOLE_RS07725
uniprot id: A8ZZF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

96561:DOLE RS04155
gene id: 96561:DOLE_RS04155
uniprot id: A8ZVQ7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

96561:DOLE RS05655
gene id: 96561:DOLE_RS05655
uniprot id: A8ZX54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

96561:DOLE RS04135
gene id: 96561:DOLE_RS04135
uniprot id: A8ZVF1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

96561:DOLE RS06545
gene id: 96561:DOLE_RS06545
uniprot id: A8ZY76
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

96561:DOLE RS10560
gene id: 96561:DOLE_RS10560
uniprot id: A8ZTS5
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS16000
gene id: 96561:DOLE_RS16000
uniprot id: A8ZZP1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

96561:DOLE RS05205
gene id: 96561:DOLE_RS05205
uniprot id: A8ZWW7
names: Caution
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS03755
gene id: 96561:DOLE_RS03755
uniprot id: A8ZV77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

96561:DOLE RS07550
gene id: 96561:DOLE_RS07550
uniprot id: A8ZZB8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

96561:DOLE RS02795
gene id: 96561:DOLE_RS02795
uniprot id: A8ZU47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

96561:DOLE RS05875
gene id: 96561:DOLE_RS05875
uniprot id: A8ZXJ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm
messages: Monomer.

96561:DOLE RS11475
gene id: 96561:DOLE_RS11475
uniprot id: A8ZUK4
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

96561:DOLE RS11190
gene id: 96561:DOLE_RS11190
uniprot id: A8ZUE9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

96561:DOLE RS09435
gene id: 96561:DOLE_RS09435
uniprot id: A8ZSA3
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS11765
gene id: 96561:DOLE_RS11765
uniprot id: A8ZV03
names: Similarity
messages: Belongs to the AOR/FOR family.

96561:DOLE RS10155
gene id: 96561:DOLE_RS10155
uniprot id: A8ZTA1
names: Similarity
messages: Belongs to the peptidase S49 family.

96561:DOLE RS13270
gene id: 96561:DOLE_RS13270
uniprot id: A8ZWQ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

96561:DOLE RS06580
gene id: 96561:DOLE_RS06580
uniprot id: A8ZY83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

96561:DOLE RS05650
gene id: 96561:DOLE_RS05650
uniprot id: A8ZX53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

96561:DOLE RS02290
gene id: 96561:DOLE_RS02290
uniprot id: A8ZTK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

96561:DOLE RS10775
gene id: 96561:DOLE_RS10775
uniprot id: A8ZTW7
names: Similarity
messages: Belongs to the HsdR family.

96561:DOLE RS00465
gene id: 96561:DOLE_RS00465
uniprot id: A8ZRY6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

96561:DOLE RS09530
gene id: 96561:DOLE_RS09530
uniprot id: A8ZSC1
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

96561:DOLE RS04800
gene id: 96561:DOLE_RS04800
uniprot id: A8ZWD4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

96561:DOLE RS11535
gene id: 96561:DOLE_RS11535
uniprot id: A8ZUV7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

96561:DOLE RS04950
gene id: 96561:DOLE_RS04950
uniprot id: A8ZWG4
names: Function
names: Similarity
messages: Belongs to the acetyltransferase family. EctA subfamily.
messages: Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.

96561:DOLE RS03880
gene id: 96561:DOLE_RS03880
uniprot id: A8ZVA2
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

96561:DOLE RS04410
gene id: 96561:DOLE_RS04410
uniprot id: A8ZVV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell inner membrane
messages: Mediates zinc uptake. May also transport other divalent cations.

96561:DOLE RS10480
gene id: 96561:DOLE_RS10480
uniprot id: A8ZTR1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

96561:DOLE RS14400
gene id: 96561:DOLE_RS14400
uniprot id: A8ZXX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

96561:DOLE RS08455
gene id: 96561:DOLE_RS08455
uniprot id: A9A0F0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.

96561:DOLE RS09880
gene id: 96561:DOLE_RS09880
uniprot id: A8ZSJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

96561:DOLE RS16600
gene id: 96561:DOLE_RS16600
uniprot id: A9A0B0
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS06815
gene id: 96561:DOLE_RS06815
uniprot id: A8ZYM7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

96561:DOLE RS07670
gene id: 96561:DOLE_RS07670
uniprot id: A8ZZE2
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

96561:DOLE RS05055
gene id: 96561:DOLE_RS05055
uniprot id: A8ZWI5
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

96561:DOLE RS03630
gene id: 96561:DOLE_RS03630
uniprot id: A8ZV52
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

96561:DOLE RS00095
gene id: 96561:DOLE_RS00095
uniprot id: A8ZRR2
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS13755
gene id: 96561:DOLE_RS13755
uniprot id: A8ZXA4
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

96561:DOLE RS09165
gene id: 96561:DOLE_RS09165
uniprot id: A9A0W1
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

96561:DOLE RS03635
gene id: 96561:DOLE_RS03635
uniprot id: A8ZV53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

96561:DOLE RS01485
gene id: 96561:DOLE_RS01485
uniprot id: A8ZS87
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

96561:DOLE RS12915
gene id: 96561:DOLE_RS12915
uniprot id: A8ZW86
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

96561:DOLE RS11565
gene id: 96561:DOLE_RS11565
uniprot id: A8ZUW2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

96561:DOLE RS02780
gene id: 96561:DOLE_RS02780
uniprot id: A8ZU44
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

96561:DOLE RS12565
gene id: 96561:DOLE_RS12565
uniprot id: A8ZW20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

96561:DOLE RS02405
gene id: 96561:DOLE_RS02405
uniprot id: A8ZTM2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS17655
gene id: 96561:DOLE_RS17655
uniprot id: A8ZZ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

96561:DOLE RS11230
gene id: 96561:DOLE_RS11230
uniprot id: A8ZUF7
names: Similarity
messages: Belongs to the transglycosylase Slt family.

96561:DOLE RS00800
gene id: 96561:DOLE_RS00800
uniprot id: A8ZSQ7
names: Similarity
messages: Belongs to the universal stress protein A family.

96561:DOLE RS03710
gene id: 96561:DOLE_RS03710
uniprot id: A8ZV68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

96561:DOLE RS09120
gene id: 96561:DOLE_RS09120
uniprot id: A9A0V3
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS15650
gene id: 96561:DOLE_RS15650
uniprot id: A8ZZ71
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

96561:DOLE RS10005
gene id: 96561:DOLE_RS10005
uniprot id: A8ZT71
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

96561:DOLE RS15335
gene id: 96561:DOLE_RS15335
uniprot id: A8ZZ10
names: Similarity
messages: Belongs to the UPF0166 family.

96561:DOLE RS17255
gene id: 96561:DOLE_RS17255
uniprot id: A8ZZ84
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

96561:DOLE RS13570
gene id: 96561:DOLE_RS13570
uniprot id: A8ZX67
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

96561:DOLE RS03620
gene id: 96561:DOLE_RS03620
uniprot id: A8ZV50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

96561:DOLE RS16350
gene id: 96561:DOLE_RS16350
uniprot id: A9A062
names: Similarity
messages: Belongs to the histone deacetylase family.

96561:DOLE RS06670
gene id: 96561:DOLE_RS06670
uniprot id: A8ZYA1
names: Similarity
messages: Belongs to the polysaccharide synthase family.

96561:DOLE RS06045
gene id: 96561:DOLE_RS06045
uniprot id: A8ZXM8
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

96561:DOLE RS03740
gene id: 96561:DOLE_RS03740
uniprot id: A8ZV74
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

96561:DOLE RS08130
gene id: 96561:DOLE_RS08130
uniprot id: A8ZZY5
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

96561:DOLE RS07240
gene id: 96561:DOLE_RS07240
uniprot id: A8ZYV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

96561:DOLE RS10715
gene id: 96561:DOLE_RS10715
uniprot id: A8ZTV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

96561:DOLE RS13255
gene id: 96561:DOLE_RS13255
uniprot id: A8ZWQ5
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

96561:DOLE RS02500
gene id: 96561:DOLE_RS02500
uniprot id: A8ZTP1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

96561:DOLE RS17660
gene id: 96561:DOLE_RS17660
uniprot id: A8ZZK7
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS14875
gene id: 96561:DOLE_RS14875
uniprot id: A8ZYG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

96561:DOLE RS02400
gene id: 96561:DOLE_RS02400
uniprot id: A8ZTM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

96561:DOLE RS11415
gene id: 96561:DOLE_RS11415
uniprot id: A8ZUJ2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS08540
gene id: 96561:DOLE_RS08540
uniprot id: A9A0G7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

96561:DOLE RS08095
gene id: 96561:DOLE_RS08095
uniprot id: A8ZZX8
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

96561:DOLE RS07340
gene id: 96561:DOLE_RS07340
uniprot id: A8ZZ78
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Belongs to the GARS family.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

96561:DOLE RS00430
gene id: 96561:DOLE_RS00430
uniprot id: A8ZRX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

96561:DOLE RS07575
gene id: 96561:DOLE_RS07575
uniprot id: A8ZZC3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

96561:DOLE RS07975
gene id: 96561:DOLE_RS07975
uniprot id: A8ZZV5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

96561:DOLE RS01550
gene id: 96561:DOLE_RS01550
uniprot id: A8ZSV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

96561:DOLE RS04140
gene id: 96561:DOLE_RS04140
uniprot id: A8ZVF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

96561:DOLE RS00780
gene id: 96561:DOLE_RS00780
uniprot id: A8ZSQ3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

96561:DOLE RS18525
gene id: 96561:DOLE_RS18525
uniprot id: A8ZXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

96561:DOLE RS07365
gene id: 96561:DOLE_RS07365
uniprot id: A8ZZ82
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS16235
gene id: 96561:DOLE_RS16235
uniprot id: A9A039
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS09850
gene id: 96561:DOLE_RS09850
uniprot id: A8ZSI8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS16365
gene id: 96561:DOLE_RS16365
uniprot id: A9A065
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS00875
gene id: 96561:DOLE_RS00875
uniprot id: A8ZSS1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

96561:DOLE RS01470
gene id: 96561:DOLE_RS01470
uniprot id: A8ZS85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

96561:DOLE RS04790
gene id: 96561:DOLE_RS04790
uniprot id: A8ZWD2
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

96561:DOLE RS03465
gene id: 96561:DOLE_RS03465
uniprot id: A8ZUS0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

96561:DOLE RS00450
gene id: 96561:DOLE_RS00450
uniprot id: A8ZRY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

96561:DOLE RS08730
gene id: 96561:DOLE_RS08730
uniprot id: A9A0K4
names: Similarity
messages: Belongs to the YoeB family.

96561:DOLE RS09230
gene id: 96561:DOLE_RS09230
uniprot id: A9A0X5
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS11360
gene id: 96561:DOLE_RS11360
uniprot id: A8ZUI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

96561:DOLE RS03055
gene id: 96561:DOLE_RS03055
uniprot id: A8ZU97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

96561:DOLE RS07170
gene id: 96561:DOLE_RS07170
uniprot id: A8ZYU4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS07660
gene id: 96561:DOLE_RS07660
uniprot id: A8ZZE0
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS03220
gene id: 96561:DOLE_RS03220
uniprot id: A8ZUM4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

96561:DOLE RS04125
gene id: 96561:DOLE_RS04125
uniprot id: A8ZVE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

96561:DOLE RS01810
gene id: 96561:DOLE_RS01810
uniprot id: A8ZT05
names: Similarity
messages: Belongs to the lipase chaperone family.

96561:DOLE RS09045
gene id: 96561:DOLE_RS09045
uniprot id: A9A0T8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

96561:DOLE RS10370
gene id: 96561:DOLE_RS10370
uniprot id: A8ZTE3
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS06235
gene id: 96561:DOLE_RS06235
uniprot id: A8ZXR5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

96561:DOLE RS15295
gene id: 96561:DOLE_RS15295
uniprot id: A8ZZ02
names: Subunit
messages: Heterodimer of a large and a small subunit.

96561:DOLE RS08495
gene id: 96561:DOLE_RS08495
uniprot id: A9A0F8
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS00365
gene id: 96561:DOLE_RS00365
uniprot id: A8ZRW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

96561:DOLE RS04795
gene id: 96561:DOLE_RS04795
uniprot id: A8ZWD3
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

96561:DOLE RS08525
gene id: 96561:DOLE_RS08525
uniprot id: A9A0G4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

96561:DOLE RS08830
gene id: 96561:DOLE_RS08830
uniprot id: A9A0M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

96561:DOLE RS15420
gene id: 96561:DOLE_RS15420
uniprot id: A8ZZ26
names: Similarity
messages: Belongs to the Ahb/Nir family.

96561:DOLE RS11585
gene id: 96561:DOLE_RS11585
uniprot id: A8ZUW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

96561:DOLE RS13390
gene id: 96561:DOLE_RS13390
uniprot id: A8ZWS9
names: Similarity
messages: Belongs to the YoeB family.

96561:DOLE RS12350
gene id: 96561:DOLE_RS12350
uniprot id: A8ZVM5
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS00405
gene id: 96561:DOLE_RS00405
uniprot id: A8ZRX4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

96561:DOLE RS00020
gene id: 96561:DOLE_RS00020
uniprot id: A8ZRP7
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

96561:DOLE RS06830
gene id: 96561:DOLE_RS06830
uniprot id: A8ZYN0
names: Similarity
messages: Belongs to the universal stress protein A family.

96561:DOLE RS02745
gene id: 96561:DOLE_RS02745
uniprot id: A8ZU39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

96561:DOLE RS07815
gene id: 96561:DOLE_RS07815
uniprot id: A8ZZH0
names: Similarity
messages: Belongs to the Nth/MutY family.

96561:DOLE RS14890
gene id: 96561:DOLE_RS14890
uniprot id: A8ZYH2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

96561:DOLE RS11390
gene id: 96561:DOLE_RS11390
uniprot id: A8ZUI8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

96561:DOLE RS03070
gene id: 96561:DOLE_RS03070
uniprot id: A8ZUA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

96561:DOLE RS08530
gene id: 96561:DOLE_RS08530
uniprot id: A9A0G5
names: Similarity
messages: Belongs to the TlyA family.

96561:DOLE RS03235
gene id: 96561:DOLE_RS03235
uniprot id: A8ZUM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

96561:DOLE RS11450
gene id: 96561:DOLE_RS11450
uniprot id: A8ZUJ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS01050
gene id: 96561:DOLE_RS01050
uniprot id: A8ZS01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

96561:DOLE RS14515
gene id: 96561:DOLE_RS14515
uniprot id: A8ZXZ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

96561:DOLE RS03135
gene id: 96561:DOLE_RS03135
uniprot id: A8ZUK7
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS13045
gene id: 96561:DOLE_RS13045
uniprot id: A8ZWL4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

96561:DOLE RS10350
gene id: 96561:DOLE_RS10350
uniprot id: A8ZTD9
names: Subcellular Location Annotation
messages: Cytoplasm

96561:DOLE RS03250
gene id: 96561:DOLE_RS03250
uniprot id: A8ZUM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

96561:DOLE RS00090
gene id: 96561:DOLE_RS00090
uniprot id: A8ZRR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Membrane raft

96561:DOLE RS04840
gene id: 96561:DOLE_RS04840
uniprot id: A8ZWE1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

96561:DOLE RS06100
gene id: 96561:DOLE_RS06100
uniprot id: A8ZXN9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

96561:DOLE RS04095
gene id: 96561:DOLE_RS04095
uniprot id: A8ZVE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

96561:DOLE RS15385
gene id: 96561:DOLE_RS15385
uniprot id: A8ZZ19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

96561:DOLE RS12805
gene id: 96561:DOLE_RS12805
uniprot id: A8ZW65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

96561:DOLE RS13690
gene id: 96561:DOLE_RS13690
uniprot id: A8ZX91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

96561:DOLE RS07970
gene id: 96561:DOLE_RS07970
uniprot id: A8ZZV4
names: Subcellular Location Annotation
messages: Peroxisome

96561:DOLE RS03700
gene id: 96561:DOLE_RS03700
uniprot id: A8ZV66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

96561:DOLE RS07505
gene id: 96561:DOLE_RS07505
uniprot id: A8ZZA9
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

96561:DOLE RS04590
gene id: 96561:DOLE_RS04590
uniprot id: A8ZVZ3
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

96561:DOLE RS03500
gene id: 96561:DOLE_RS03500
uniprot id: A8ZUS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

96561:DOLE RS08885
gene id: 96561:DOLE_RS08885
uniprot id: A9A0N3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

96561:DOLE RS07675
gene id: 96561:DOLE_RS07675
uniprot id: A8ZZE3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

96561:DOLE RS12580
gene id: 96561:DOLE_RS12580
uniprot id: A8ZW23
names: Similarity
messages: Belongs to the peptidase S41A family.

96561:DOLE RS16305
gene id: 96561:DOLE_RS16305
uniprot id: A9A053
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

96561:DOLE RS05325
gene id: 96561:DOLE_RS05325
uniprot id: A8ZWZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS11295
gene id: 96561:DOLE_RS11295
uniprot id: A8ZUG9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

96561:DOLE RS13240
gene id: 96561:DOLE_RS13240
uniprot id: A8ZWQ2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

96561:DOLE RS16700
gene id: 96561:DOLE_RS16700
uniprot id: A9A0C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS12445
gene id: 96561:DOLE_RS12445
uniprot id: A8ZVP4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

96561:DOLE RS14605
gene id: 96561:DOLE_RS14605
uniprot id: A8ZY13
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

96561:DOLE RS01900
gene id: 96561:DOLE_RS01900
uniprot id: A8ZT23
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS11480
gene id: 96561:DOLE_RS11480
uniprot id: A8ZUK5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

96561:DOLE RS11950
gene id: 96561:DOLE_RS11950
uniprot id: A8ZV41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

96561:DOLE RS12825
gene id: 96561:DOLE_RS12825
uniprot id: A8ZW69
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

96561:DOLE RS07490
gene id: 96561:DOLE_RS07490
uniprot id: A8ZZA6
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

96561:DOLE RS05610
gene id: 96561:DOLE_RS05610
uniprot id: A8ZX45
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS08835
gene id: 96561:DOLE_RS08835
uniprot id: A9A0M3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

96561:DOLE RS14895
gene id: 96561:DOLE_RS14895
uniprot id: A8ZYH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS13175
gene id: 96561:DOLE_RS13175
uniprot id: A8ZWP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

96561:DOLE RS01635
gene id: 96561:DOLE_RS01635
uniprot id: A8ZSX0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

96561:DOLE RS13450
gene id: 96561:DOLE_RS13450
uniprot id: A8ZWU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS01030
gene id: 96561:DOLE_RS01030
uniprot id: A8ZRZ7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

96561:DOLE RS01135
gene id: 96561:DOLE_RS01135
uniprot id: A8ZS21
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

96561:DOLE RS11995
gene id: 96561:DOLE_RS11995
uniprot id: A8ZVF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

96561:DOLE RS01540
gene id: 96561:DOLE_RS01540
uniprot id: A8ZSV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

96561:DOLE RS03675
gene id: 96561:DOLE_RS03675
uniprot id: A8ZV61
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

96561:DOLE RS09695
gene id: 96561:DOLE_RS09695
uniprot id: A8ZSF3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

96561:DOLE RS07515
gene id: 96561:DOLE_RS07515
uniprot id: A8ZZB1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

96561:DOLE RS02630
gene id: 96561:DOLE_RS02630
uniprot id: A8ZU17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

96561:DOLE RS09170
gene id: 96561:DOLE_RS09170
uniprot id: A9A0W2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

96561:DOLE RS08045
gene id: 96561:DOLE_RS08045
uniprot id: A8ZZW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

96561:DOLE RS14095
gene id: 96561:DOLE_RS14095
uniprot id: A8ZXR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

96561:DOLE RS13840
gene id: 96561:DOLE_RS13840
uniprot id: A8ZXB9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

96561:DOLE RS00460
gene id: 96561:DOLE_RS00460
uniprot id: A8ZRY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

96561:DOLE RS08460
gene id: 96561:DOLE_RS08460
uniprot id: A9A0F1
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

96561:DOLE RS09870
gene id: 96561:DOLE_RS09870
uniprot id: A8ZSJ2
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

96561:DOLE RS03190
gene id: 96561:DOLE_RS03190
uniprot id: A8ZUL8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

96561:DOLE RS06405
gene id: 96561:DOLE_RS06405
uniprot id: A8ZY48
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

96561:DOLE RS11380
gene id: 96561:DOLE_RS11380
uniprot id: A8ZUI6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

96561:DOLE RS10880
gene id: 96561:DOLE_RS10880
uniprot id: A8ZTY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

96561:DOLE RS12110
gene id: 96561:DOLE_RS12110
uniprot id: A8ZVH7
names: Similarity
messages: Belongs to the neutral ceramidase family.

96561:DOLE RS03385
gene id: 96561:DOLE_RS03385
uniprot id: A8ZUQ3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

96561:DOLE RS01880
gene id: 96561:DOLE_RS01880
uniprot id: A8ZT19
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

96561:DOLE RS11545
gene id: 96561:DOLE_RS11545
uniprot id: A8ZUV9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

96561:DOLE RS08040
gene id: 96561:DOLE_RS08040
uniprot id: A8ZZW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

96561:DOLE RS10895
gene id: 96561:DOLE_RS10895
uniprot id: A8ZTZ1
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

96561:DOLE RS13385
gene id: 96561:DOLE_RS13385
uniprot id: A8ZWS8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

96561:DOLE RS16070
gene id: 96561:DOLE_RS16070
uniprot id: A8ZZQ4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS11710
gene id: 96561:DOLE_RS11710
uniprot id: A8ZUZ2
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS04425
gene id: 96561:DOLE_RS04425
uniprot id: A8ZVW0
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS11965
gene id: 96561:DOLE_RS11965
uniprot id: A8ZV44
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

96561:DOLE RS11870
gene id: 96561:DOLE_RS11870
uniprot id: A8ZV24
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

96561:DOLE RS14670
gene id: 96561:DOLE_RS14670
uniprot id: A8ZYC8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

96561:DOLE RS14650
gene id: 96561:DOLE_RS14650
uniprot id: A8ZYC4
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS00745
gene id: 96561:DOLE_RS00745
uniprot id: A8ZSP8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

96561:DOLE RS14065
gene id: 96561:DOLE_RS14065
uniprot id: A8ZXF9
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

96561:DOLE RS14270
gene id: 96561:DOLE_RS14270
uniprot id: A8ZXV1
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

96561:DOLE RS00135
gene id: 96561:DOLE_RS00135
uniprot id: A8ZRR9
names: Similarity
messages: Belongs to the citrate synthase family.

96561:DOLE RS11650
gene id: 96561:DOLE_RS11650
uniprot id: A8ZUY0
names: Similarity
messages: Belongs to the glutamate synthase family.

96561:DOLE RS02510
gene id: 96561:DOLE_RS02510
uniprot id: A8ZTP3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS02535
gene id: 96561:DOLE_RS02535
uniprot id: A8ZTP6
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

96561:DOLE RS05480
gene id: 96561:DOLE_RS05480
uniprot id: A8ZX21
names: Cofactor
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Binds 1 Mg(2+) ion per subunit.

96561:DOLE RS07290
gene id: 96561:DOLE_RS07290
uniprot id: A8ZYW8
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

96561:DOLE RS10125
gene id: 96561:DOLE_RS10125
uniprot id: A8ZT95
names: Similarity
messages: Belongs to the histone deacetylase family.

96561:DOLE RS00440
gene id: 96561:DOLE_RS00440
uniprot id: A8ZRY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

96561:DOLE RS15785
gene id: 96561:DOLE_RS15785
uniprot id: A8ZZJ7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

96561:DOLE RS03665
gene id: 96561:DOLE_RS03665
uniprot id: A8ZV59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

96561:DOLE RS01935
gene id: 96561:DOLE_RS01935
uniprot id: A8ZT30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

96561:DOLE RS12695
gene id: 96561:DOLE_RS12695
uniprot id: A8ZW44
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

96561:DOLE RS03460
gene id: 96561:DOLE_RS03460
uniprot id: A8ZUR8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

96561:DOLE RS06515
gene id: 96561:DOLE_RS06515
uniprot id: A8ZY70
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

96561:DOLE RS16575
gene id: 96561:DOLE_RS16575
uniprot id: A9A0A6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS00130
gene id: 96561:DOLE_RS00130
uniprot id: A8ZRR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

96561:DOLE RS00495
gene id: 96561:DOLE_RS00495
uniprot id: A8ZRZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

96561:DOLE RS03760
gene id: 96561:DOLE_RS03760
uniprot id: A8ZV78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

96561:DOLE RS16440
gene id: 96561:DOLE_RS16440
uniprot id: A9A080
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

96561:DOLE RS06110
gene id: 96561:DOLE_RS06110
uniprot id: A8ZXP1
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

96561:DOLE RS05685
gene id: 96561:DOLE_RS05685
uniprot id: A8ZX60
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

96561:DOLE RS14160
gene id: 96561:DOLE_RS14160
uniprot id: A8ZXT1
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

96561:DOLE RS01555
gene id: 96561:DOLE_RS01555
uniprot id: A8ZSV5
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS08650
gene id: 96561:DOLE_RS08650
uniprot id: A9A0I9
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

96561:DOLE RS01850
gene id: 96561:DOLE_RS01850
uniprot id: A8ZT13
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

96561:DOLE RS05935
gene id: 96561:DOLE_RS05935
uniprot id: A8ZXK7
names: Similarity
messages: Belongs to the HdrA family.

96561:DOLE RS03060
gene id: 96561:DOLE_RS03060
uniprot id: A8ZU98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

96561:DOLE RS07665
gene id: 96561:DOLE_RS07665
uniprot id: A8ZZE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

96561:DOLE RS06685
gene id: 96561:DOLE_RS06685
uniprot id: A8ZYA4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS15755
gene id: 96561:DOLE_RS15755
uniprot id: A8ZZJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

96561:DOLE RS12525
gene id: 96561:DOLE_RS12525
uniprot id: A8ZW12
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

96561:DOLE RS14210
gene id: 96561:DOLE_RS14210
uniprot id: A8ZXU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

96561:DOLE RS00230
gene id: 96561:DOLE_RS00230
uniprot id: A8ZRT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

96561:DOLE RS01000
gene id: 96561:DOLE_RS01000
uniprot id: A8ZSU6
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS15655
gene id: 96561:DOLE_RS15655
uniprot id: A8ZZ72
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

96561:DOLE RS17030
gene id: 96561:DOLE_RS17030
uniprot id: A8ZVX4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

96561:DOLE RS15055
gene id: 96561:DOLE_RS15055
uniprot id: A8ZYK4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

96561:DOLE RS16570
gene id: 96561:DOLE_RS16570
uniprot id: A9A0A5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS10335
gene id: 96561:DOLE_RS10335
uniprot id: A8ZTD6
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

96561:DOLE RS03555
gene id: 96561:DOLE_RS03555
uniprot id: A8ZUU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

96561:DOLE RS16240
gene id: 96561:DOLE_RS16240
uniprot id: A9A040
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS15460
gene id: 96561:DOLE_RS15460
uniprot id: A8ZZ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

96561:DOLE RS04570
gene id: 96561:DOLE_RS04570
uniprot id: A8ZVY9
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS02605
gene id: 96561:DOLE_RS02605
uniprot id: A8ZU12
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

96561:DOLE RS08060
gene id: 96561:DOLE_RS08060
uniprot id: A8ZZX1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

96561:DOLE RS11095
gene id: 96561:DOLE_RS11095
uniprot id: A8ZUD0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

96561:DOLE RS15960
gene id: 96561:DOLE_RS15960
uniprot id: A8ZZN3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS12140
gene id: 96561:DOLE_RS12140
uniprot id: A8ZVI3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS04290
gene id: 96561:DOLE_RS04290
uniprot id: A8ZVT4
names: Similarity
messages: Belongs to the leucine-binding protein family.

96561:DOLE RS13735
gene id: 96561:DOLE_RS13735
uniprot id: A8ZXA0
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS15910
gene id: 96561:DOLE_RS15910
uniprot id: A8ZW27
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

96561:DOLE RS03025
gene id: 96561:DOLE_RS03025
uniprot id: A8ZU91
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

96561:DOLE RS01720
gene id: 96561:DOLE_RS01720
uniprot id: A8ZSY7
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS11695
gene id: 96561:DOLE_RS11695
uniprot id: A8ZUY9
names: Similarity
messages: Belongs to the glutamate synthase family.

96561:DOLE RS03185
gene id: 96561:DOLE_RS03185
uniprot id: A8ZUL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

96561:DOLE RS13030
gene id: 96561:DOLE_RS13030
uniprot id: A8ZWA8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

96561:DOLE RS09090
gene id: 96561:DOLE_RS09090
uniprot id: A9A0U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS05140
gene id: 96561:DOLE_RS05140
uniprot id: A8ZWK2
names: Similarity
messages: Belongs to the HdrA family.

96561:DOLE RS13670
gene id: 96561:DOLE_RS13670
uniprot id: A8ZX87
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

96561:DOLE RS08535
gene id: 96561:DOLE_RS08535
uniprot id: A9A0G6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

96561:DOLE RS01875
gene id: 96561:DOLE_RS01875
uniprot id: A8ZT18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

96561:DOLE RS01870
gene id: 96561:DOLE_RS01870
uniprot id: A8ZT17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

96561:DOLE RS12790
gene id: 96561:DOLE_RS12790
uniprot id: A8ZW62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

96561:DOLE RS11005
gene id: 96561:DOLE_RS11005
uniprot id: A8ZUB4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

96561:DOLE RS11785
gene id: 96561:DOLE_RS11785
uniprot id: A8ZV07
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

96561:DOLE RS07440
gene id: 96561:DOLE_RS07440
uniprot id: A8ZZ97
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS04035
gene id: 96561:DOLE_RS04035
uniprot id: A8ZVD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

96561:DOLE RS05675
gene id: 96561:DOLE_RS05675
uniprot id: A8ZX58
names: Similarity
messages: Belongs to the asparagine synthetase family.

96561:DOLE RS02335
gene id: 96561:DOLE_RS02335
uniprot id: A8ZTK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

96561:DOLE RS11955
gene id: 96561:DOLE_RS11955
uniprot id: A8ZV42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS06000
gene id: 96561:DOLE_RS06000
uniprot id: A8ZXL9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

96561:DOLE RS10425
gene id: 96561:DOLE_RS10425
uniprot id: A8ZTF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

96561:DOLE RS10000
gene id: 96561:DOLE_RS10000
uniprot id: A8ZT70
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

96561:DOLE RS01615
gene id: 96561:DOLE_RS01615
uniprot id: A8ZSW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

96561:DOLE RS07735
gene id: 96561:DOLE_RS07735
uniprot id: A8ZZF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.

96561:DOLE RS16255
gene id: 96561:DOLE_RS16255
uniprot id: A9A043
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

96561:DOLE RS18660
gene id: 96561:DOLE_RS18660
uniprot id: A8ZV83
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

96561:DOLE RS12180
gene id: 96561:DOLE_RS12180
uniprot id: A8ZVJ1
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

96561:DOLE RS13630
gene id: 96561:DOLE_RS13630
uniprot id: A8ZX79
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

96561:DOLE RS10080
gene id: 96561:DOLE_RS10080
uniprot id: A8ZT86
names: Function
names: Similarity
messages: Belongs to the rhamnosyl O-methyltransferase family.
messages: Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD).

96561:DOLE RS17405
gene id: 96561:DOLE_RS17405
uniprot id: A8ZSJ1
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

96561:DOLE RS11215
gene id: 96561:DOLE_RS11215
uniprot id: A8ZUF4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS12460
gene id: 96561:DOLE_RS12460
uniprot id: A8ZVP6
names: Similarity
messages: Belongs to the MEMO1 family.

96561:DOLE RS15805
gene id: 96561:DOLE_RS15805
uniprot id: A8ZZK1
names: Similarity
messages: Belongs to the thioredoxin family.

96561:DOLE RS00945
gene id: 96561:DOLE_RS00945
uniprot id: A8ZST5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

96561:DOLE RS15645
gene id: 96561:DOLE_RS15645
uniprot id: A8ZZ70
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

96561:DOLE RS05810
gene id: 96561:DOLE_RS05810
uniprot id: A8ZXI3
names: Cofactor
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Binds 1 Mg(2+) ion per subunit.

96561:DOLE RS02310
gene id: 96561:DOLE_RS02310
uniprot id: A8ZTK4
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

96561:DOLE RS03625
gene id: 96561:DOLE_RS03625
uniprot id: A8ZV51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

96561:DOLE RS12780
gene id: 96561:DOLE_RS12780
uniprot id: A8ZW60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

96561:DOLE RS07840
gene id: 96561:DOLE_RS07840
uniprot id: A8ZZH5
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

96561:DOLE RS08910
gene id: 96561:DOLE_RS08910
uniprot id: A9A0R3
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

96561:DOLE RS16540
gene id: 96561:DOLE_RS16540
uniprot id: A9A099
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

96561:DOLE RS03585
gene id: 96561:DOLE_RS03585
uniprot id: A8ZUU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

96561:DOLE RS03530
gene id: 96561:DOLE_RS03530
uniprot id: A8ZUT5
names: Similarity
messages: Belongs to the archease family.

96561:DOLE RS01025
gene id: 96561:DOLE_RS01025
uniprot id: A8ZRZ6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS02375
gene id: 96561:DOLE_RS02375
uniprot id: A8ZTL6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS01505
gene id: 96561:DOLE_RS01505
uniprot id: A8ZS91
names: Similarity
messages: Belongs to the MEMO1 family.

96561:DOLE RS00435
gene id: 96561:DOLE_RS00435
uniprot id: A8ZRY0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

96561:DOLE RS02585
gene id: 96561:DOLE_RS02585
uniprot id: A8ZU08
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

96561:DOLE RS11280
gene id: 96561:DOLE_RS11280
uniprot id: A8ZUG6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

96561:DOLE RS13830
gene id: 96561:DOLE_RS13830
uniprot id: A8ZXB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

96561:DOLE RS11335
gene id: 96561:DOLE_RS11335
uniprot id: A8ZUH7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

96561:DOLE RS07235
gene id: 96561:DOLE_RS07235
uniprot id: A8ZYV7
names: Similarity
messages: Belongs to the GSP E family.

96561:DOLE RS07985
gene id: 96561:DOLE_RS07985
uniprot id: A8ZZV7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS05050
gene id: 96561:DOLE_RS05050
uniprot id: A8ZWI4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

96561:DOLE RS07495
gene id: 96561:DOLE_RS07495
uniprot id: A8ZZA7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

96561:DOLE RS03910
gene id: 96561:DOLE_RS03910
uniprot id: A8ZVA8
names: Similarity
messages: Belongs to the thioesterase PaaI family.

96561:DOLE RS03815
gene id: 96561:DOLE_RS03815
uniprot id: A8ZV89
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

96561:DOLE RS02565
gene id: 96561:DOLE_RS02565
uniprot id: A8ZTQ2
names: Similarity
messages: Belongs to the sigma-54 factor family.

96561:DOLE RS08815
gene id: 96561:DOLE_RS08815
uniprot id: A9A0L9
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

96561:DOLE RS00370
gene id: 96561:DOLE_RS00370
uniprot id: A8ZRW7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

96561:DOLE RS00560
gene id: 96561:DOLE_RS00560
uniprot id: A8ZSL0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

96561:DOLE RS05640
gene id: 96561:DOLE_RS05640
uniprot id: A8ZX51
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

96561:DOLE RS08510
gene id: 96561:DOLE_RS08510
uniprot id: A9A0G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS10035
gene id: 96561:DOLE_RS10035
uniprot id: A8ZT77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

96561:DOLE RS03980
gene id: 96561:DOLE_RS03980
uniprot id: A8ZVC2
names: Similarity
messages: Belongs to the aspartokinase family.

96561:DOLE RS13750
gene id: 96561:DOLE_RS13750
uniprot id: A8ZXA3
names: Similarity
messages: Belongs to the CapA family.

96561:DOLE RS07860
gene id: 96561:DOLE_RS07860
uniprot id: A8ZZT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

96561:DOLE RS10965
gene id: 96561:DOLE_RS10965
uniprot id: A8ZU05
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

96561:DOLE RS18140
gene id: 96561:DOLE_RS18140
uniprot id: A8ZWG2
names: Function
names: Similarity
messages: Belongs to the ectoine synthase family.
messages: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.

96561:DOLE RS03475
gene id: 96561:DOLE_RS03475
uniprot id: A8ZUS2
names: Similarity
messages: Belongs to the UPF0758 family.

96561:DOLE RS03690
gene id: 96561:DOLE_RS03690
uniprot id: A8ZV64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

96561:DOLE RS05190
gene id: 96561:DOLE_RS05190
uniprot id: A8ZWW4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

96561:DOLE RS03770
gene id: 96561:DOLE_RS03770
uniprot id: A8ZV80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

96561:DOLE RS04955
gene id: 96561:DOLE_RS04955
uniprot id: A8ZWG5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

96561:DOLE RS05965
gene id: 96561:DOLE_RS05965
uniprot id: A8ZXL3
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

96561:DOLE RS04870
gene id: 96561:DOLE_RS04870
uniprot id: A8ZWE7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

96561:DOLE RS03030
gene id: 96561:DOLE_RS03030
uniprot id: A8ZU92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

96561:DOLE RS11030
gene id: 96561:DOLE_RS11030
uniprot id: A8ZUB9
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

96561:DOLE RS12215
gene id: 96561:DOLE_RS12215
uniprot id: A8ZVJ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

96561:DOLE RS08550
gene id: 96561:DOLE_RS08550
uniprot id: A9A0G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

96561:DOLE RS12190
gene id: 96561:DOLE_RS12190
uniprot id: A8ZVJ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

96561:DOLE RS07980
gene id: 96561:DOLE_RS07980
uniprot id: A8ZZV6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS04785
gene id: 96561:DOLE_RS04785
uniprot id: A8ZWD1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS14775
gene id: 96561:DOLE_RS14775
uniprot id: A8ZYE8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.
messages: Homodimer.

96561:DOLE RS00940
gene id: 96561:DOLE_RS00940
uniprot id: A8ZST4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

96561:DOLE RS10160
gene id: 96561:DOLE_RS10160
uniprot id: A8ZTA2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.

96561:DOLE RS12085
gene id: 96561:DOLE_RS12085
uniprot id: A8ZVH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

96561:DOLE RS12810
gene id: 96561:DOLE_RS12810
uniprot id: A8ZW66
names: Similarity
messages: Belongs to the peptidase T1B family. HslV subfamily.

96561:DOLE RS02530
gene id: 96561:DOLE_RS02530
uniprot id: A8ZTP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

96561:DOLE RS02025
gene id: 96561:DOLE_RS02025
uniprot id: A8ZT48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

96561:DOLE RS11800
gene id: 96561:DOLE_RS11800
uniprot id: A8ZV10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

96561:DOLE RS13605
gene id: 96561:DOLE_RS13605
uniprot id: A8ZX74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

96561:DOLE RS00510
gene id: 96561:DOLE_RS00510
uniprot id: A8ZSK0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).

96561:DOLE RS00100
gene id: 96561:DOLE_RS00100
uniprot id: A8ZRR3
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS15040
gene id: 96561:DOLE_RS15040
uniprot id: A8ZYK1
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS15830
gene id: 96561:DOLE_RS15830
uniprot id: A8ZZK6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS16315
gene id: 96561:DOLE_RS16315
uniprot id: A9A055
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

96561:DOLE RS03670
gene id: 96561:DOLE_RS03670
uniprot id: A8ZV60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

96561:DOLE RS06665
gene id: 96561:DOLE_RS06665
uniprot id: A8ZYA0
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS01220
gene id: 96561:DOLE_RS01220
uniprot id: A8ZS37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

96561:DOLE RS00045
gene id: 96561:DOLE_RS00045
uniprot id: A8ZRQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

96561:DOLE RS16550
gene id: 96561:DOLE_RS16550
uniprot id: A9A0A1
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS06265
gene id: 96561:DOLE_RS06265
uniprot id: A8ZY21
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

96561:DOLE RS15590
gene id: 96561:DOLE_RS15590
uniprot id: A8ZZ60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

96561:DOLE RS16655
gene id: 96561:DOLE_RS16655
uniprot id: A9A0C1
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS00850
gene id: 96561:DOLE_RS00850
uniprot id: A8ZSR6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

96561:DOLE RS11140
gene id: 96561:DOLE_RS11140
uniprot id: A8ZUD9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

96561:DOLE RS02505
gene id: 96561:DOLE_RS02505
uniprot id: A8ZTP2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

96561:DOLE RS10475
gene id: 96561:DOLE_RS10475
uniprot id: A8ZTR0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADH to yield (R)-2,3-dihydroxy-isovalerate.

96561:DOLE RS07705
gene id: 96561:DOLE_RS07705
uniprot id: A8ZZE9
names: Similarity
messages: Belongs to the thioesterase PaaI family.

96561:DOLE RS01105
gene id: 96561:DOLE_RS01105
uniprot id: A8ZS14
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

96561:DOLE RS14430
gene id: 96561:DOLE_RS14430
uniprot id: A8ZXY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS12540
gene id: 96561:DOLE_RS12540
uniprot id: A8ZW15
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

96561:DOLE RS10165
gene id: 96561:DOLE_RS10165
uniprot id: A8ZTA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

96561:DOLE RS03505
gene id: 96561:DOLE_RS03505
uniprot id: A8ZUS8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS00605
gene id: 96561:DOLE_RS00605
uniprot id: A8ZSL9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS13565
gene id: 96561:DOLE_RS13565
uniprot id: A8ZX66
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

96561:DOLE RS02070
gene id: 96561:DOLE_RS02070
uniprot id: A8ZTF8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

96561:DOLE RS03065
gene id: 96561:DOLE_RS03065
uniprot id: A8ZU99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

96561:DOLE RS06825
gene id: 96561:DOLE_RS06825
uniprot id: A8ZYM9
names: Similarity
messages: Belongs to the universal stress protein A family.

96561:DOLE RS03520
gene id: 96561:DOLE_RS03520
uniprot id: A8ZUT1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

96561:DOLE RS05665
gene id: 96561:DOLE_RS05665
uniprot id: A8ZX56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

96561:DOLE RS02370
gene id: 96561:DOLE_RS02370
uniprot id: A8ZTL5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

96561:DOLE RS12800
gene id: 96561:DOLE_RS12800
uniprot id: A8ZW64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

96561:DOLE RS10580
gene id: 96561:DOLE_RS10580
uniprot id: A8ZTS9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS14110
gene id: 96561:DOLE_RS14110
uniprot id: A8ZXS0
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

96561:DOLE RS14550
gene id: 96561:DOLE_RS14550
uniprot id: A8ZY03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

96561:DOLE RS02740
gene id: 96561:DOLE_RS02740
uniprot id: A8ZU38
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

96561:DOLE RS15270
gene id: 96561:DOLE_RS15270
uniprot id: A8ZYZ7
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

96561:DOLE RS16495
gene id: 96561:DOLE_RS16495
uniprot id: A9A091
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

96561:DOLE RS02870
gene id: 96561:DOLE_RS02870
uniprot id: A8ZU62
names: Similarity
messages: Belongs to the P(II) protein family.

96561:DOLE RS04875
gene id: 96561:DOLE_RS04875
uniprot id: A8ZWE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

96561:DOLE RS16435
gene id: 96561:DOLE_RS16435
uniprot id: A9A079
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

96561:DOLE RS11270
gene id: 96561:DOLE_RS11270
uniprot id: A8ZUG4
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

96561:DOLE RS06300
gene id: 96561:DOLE_RS06300
uniprot id: A8ZY28
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

96561:DOLE RS11515
gene id: 96561:DOLE_RS11515
uniprot id: A8ZUV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

96561:DOLE RS03925
gene id: 96561:DOLE_RS03925
uniprot id: A8ZVB1
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

96561:DOLE RS07965
gene id: 96561:DOLE_RS07965
uniprot id: A8ZZV3
names: Subcellular Location Annotation
messages: Peroxisome

96561:DOLE RS06555
gene id: 96561:DOLE_RS06555
uniprot id: A8ZY78
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

96561:DOLE RS05900
gene id: 96561:DOLE_RS05900
uniprot id: A8ZXJ9
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

96561:DOLE RS05660
gene id: 96561:DOLE_RS05660
uniprot id: A8ZX55
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS08360
gene id: 96561:DOLE_RS08360
uniprot id: A9A031
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS03485
gene id: 96561:DOLE_RS03485
uniprot id: A8ZUS4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

96561:DOLE RS13625
gene id: 96561:DOLE_RS13625
uniprot id: A8ZX78
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

96561:DOLE RS10265
gene id: 96561:DOLE_RS10265
uniprot id: A8ZTC3
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS02610
gene id: 96561:DOLE_RS02610
uniprot id: A8ZU13
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS02425
gene id: 96561:DOLE_RS02425
uniprot id: A8ZTM6
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

96561:DOLE RS02810
gene id: 96561:DOLE_RS02810
uniprot id: A8ZU50
names: Similarity
messages: Belongs to the P(II) protein family.

96561:DOLE RS16705
gene id: 96561:DOLE_RS16705
uniprot id: A9A0D0
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

96561:DOLE RS11240
gene id: 96561:DOLE_RS11240
uniprot id: A8ZUF9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

96561:DOLE RS08055
gene id: 96561:DOLE_RS08055
uniprot id: A8ZZX0
names: Similarity
messages: Belongs to the TrpC family.

96561:DOLE RS15595
gene id: 96561:DOLE_RS15595
uniprot id: A8ZZ61
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

96561:DOLE RS02415
gene id: 96561:DOLE_RS02415
uniprot id: A8ZTM4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

96561:DOLE RS12430
gene id: 96561:DOLE_RS12430
uniprot id: A8ZVP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

96561:DOLE RS03735
gene id: 96561:DOLE_RS03735
uniprot id: A8ZV73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

96561:DOLE RS13190
gene id: 96561:DOLE_RS13190
uniprot id: A8ZWP3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

96561:DOLE RS06230
gene id: 96561:DOLE_RS06230
uniprot id: A8ZXR4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

96561:DOLE RS03835
gene id: 96561:DOLE_RS03835
uniprot id: A8ZV93
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

96561:DOLE RS02035
gene id: 96561:DOLE_RS02035
uniprot id: A8ZT50
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

96561:DOLE RS13650
gene id: 96561:DOLE_RS13650
uniprot id: A8ZX83
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

96561:DOLE RS01045
gene id: 96561:DOLE_RS01045
uniprot id: A8ZS00
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

96561:DOLE RS06305
gene id: 96561:DOLE_RS06305
uniprot id: A8ZY29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

96561:DOLE RS05495
gene id: 96561:DOLE_RS05495
uniprot id: A8ZX24
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

96561:DOLE RS10970
gene id: 96561:DOLE_RS10970
uniprot id: A8ZUA7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

96561:DOLE RS07335
gene id: 96561:DOLE_RS07335
uniprot id: A8ZZ77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

96561:DOLE RS15500
gene id: 96561:DOLE_RS15500
uniprot id: A8ZZ42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

96561:DOLE RS14855
gene id: 96561:DOLE_RS14855
uniprot id: A8ZYG3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.
messages: Membrane

96561:DOLE RS12535
gene id: 96561:DOLE_RS12535
uniprot id: A8ZW14
names: Similarity
messages: Belongs to the DprA/Smf family.

96561:DOLE RS03600
gene id: 96561:DOLE_RS03600
uniprot id: A8ZUU4
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

96561:DOLE RS10420
gene id: 96561:DOLE_RS10420
uniprot id: A8ZTF2
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

96561:DOLE RS11810
gene id: 96561:DOLE_RS11810
uniprot id: A8ZV12
names: Similarity
messages: Belongs to the UPF0102 family.

96561:DOLE RS10360
gene id: 96561:DOLE_RS10360
uniprot id: A8ZTE1
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS07255
gene id: 96561:DOLE_RS07255
uniprot id: A8ZYW1
names: Similarity
messages: Belongs to the Lgt family.

96561:DOLE RS00420
gene id: 96561:DOLE_RS00420
uniprot id: A8ZRX7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

96561:DOLE RS11460
gene id: 96561:DOLE_RS11460
uniprot id: A8ZUK1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

96561:DOLE RS12065
gene id: 96561:DOLE_RS12065
uniprot id: A8ZVG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

96561:DOLE RS01165
gene id: 96561:DOLE_RS01165
uniprot id: A8ZS26
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

96561:DOLE RS10695
gene id: 96561:DOLE_RS10695
uniprot id: A8ZTV1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

96561:DOLE RS09545
gene id: 96561:DOLE_RS09545
uniprot id: A8ZSC3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

96561:DOLE RS00050
gene id: 96561:DOLE_RS00050
uniprot id: A8ZRQ3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

96561:DOLE RS10585
gene id: 96561:DOLE_RS10585
uniprot id: A8ZTT0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

96561:DOLE RS10135
gene id: 96561:DOLE_RS10135
uniprot id: A8ZT97
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

96561:DOLE RS00595
gene id: 96561:DOLE_RS00595
uniprot id: A8ZSL7
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

96561:DOLE RS14300
gene id: 96561:DOLE_RS14300
uniprot id: A8ZXV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

96561:DOLE RS13265
gene id: 96561:DOLE_RS13265
uniprot id: A8ZWQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

96561:DOLE RS06795
gene id: 96561:DOLE_RS06795
uniprot id: A8ZYM3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

96561:DOLE RS00415
gene id: 96561:DOLE_RS00415
uniprot id: A8ZRX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

96561:DOLE RS01450
gene id: 96561:DOLE_RS01450
uniprot id: A8ZS81
names: Similarity
messages: Belongs to the UPF0235 family.

96561:DOLE RS12130
gene id: 96561:DOLE_RS12130
uniprot id: A8ZVI1
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS10595
gene id: 96561:DOLE_RS10595
uniprot id: A8ZTT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

96561:DOLE RS13620
gene id: 96561:DOLE_RS13620
uniprot id: A8ZX77
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

96561:DOLE RS00340
gene id: 96561:DOLE_RS00340
uniprot id: A8ZRW1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

96561:DOLE RS03695
gene id: 96561:DOLE_RS03695
uniprot id: A8ZV65
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

96561:DOLE RS11355
gene id: 96561:DOLE_RS11355
uniprot id: A8ZUI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane

96561:DOLE RS05970
gene id: 96561:DOLE_RS05970
uniprot id: A8ZXL4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

96561:DOLE RS03540
gene id: 96561:DOLE_RS03540
uniprot id: A8ZUT7
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS08010
gene id: 96561:DOLE_RS08010
uniprot id: A8ZZW2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

96561:DOLE RS03075
gene id: 96561:DOLE_RS03075
uniprot id: A8ZUA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

96561:DOLE RS10640
gene id: 96561:DOLE_RS10640
uniprot id: A8ZTU0
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS13545
gene id: 96561:DOLE_RS13545
uniprot id: A8ZW27
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

96561:DOLE RS03875
gene id: 96561:DOLE_RS03875
uniprot id: A8ZVA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

96561:DOLE RS14530
gene id: 96561:DOLE_RS14530
uniprot id: A8ZXZ9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

96561:DOLE RS13480
gene id: 96561:DOLE_RS13480
uniprot id: A8ZWU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

96561:DOLE RS01460
gene id: 96561:DOLE_RS01460
uniprot id: A8ZS83
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

96561:DOLE RS11345
gene id: 96561:DOLE_RS11345
uniprot id: A8ZUH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

96561:DOLE RS13025
gene id: 96561:DOLE_RS13025
uniprot id: A8ZWA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

96561:DOLE RS11100
gene id: 96561:DOLE_RS11100
uniprot id: A8ZUD1
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

96561:DOLE RS00270
gene id: 96561:DOLE_RS00270
uniprot id: A8ZRU7
names: Similarity
messages: Belongs to the DEAD box helicase family.

96561:DOLE RS13020
gene id: 96561:DOLE_RS13020
uniprot id: A8ZWA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

96561:DOLE RS08240
gene id: 96561:DOLE_RS08240
uniprot id: A9A007
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

96561:DOLE RS09790
gene id: 96561:DOLE_RS09790
uniprot id: A8ZSH5
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

96561:DOLE RS15675
gene id: 96561:DOLE_RS15675
uniprot id: A8ZZH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS16430
gene id: 96561:DOLE_RS16430
uniprot id: A9A078
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS07175
gene id: 96561:DOLE_RS07175
uniprot id: A8ZYU5
names: Similarity
messages: Belongs to the DapB family.

96561:DOLE RS10945
gene id: 96561:DOLE_RS10945
uniprot id: A8ZU01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

96561:DOLE RS14850
gene id: 96561:DOLE_RS14850
uniprot id: A8ZYG2
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS12830
gene id: 96561:DOLE_RS12830
uniprot id: A8ZW70
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS06690
gene id: 96561:DOLE_RS06690
uniprot id: A8ZYA5
names: Function
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

96561:DOLE RS06910
gene id: 96561:DOLE_RS06910
uniprot id: A8ZYP6
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS14710
gene id: 96561:DOLE_RS14710
uniprot id: A8ZYD5
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

96561:DOLE RS11405
gene id: 96561:DOLE_RS11405
uniprot id: A8ZUJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

96561:DOLE RS09300
gene id: 96561:DOLE_RS09300
uniprot id: A9A0Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

96561:DOLE RS03640
gene id: 96561:DOLE_RS03640
uniprot id: A8ZV54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

96561:DOLE RS05430
gene id: 96561:DOLE_RS05430
uniprot id: A8ZX11
names: Similarity
messages: Belongs to the LacAB/RpiB family.

96561:DOLE RS01735
gene id: 96561:DOLE_RS01735
uniprot id: A8ZSZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

96561:DOLE RS04980
gene id: 96561:DOLE_RS04980
uniprot id: A8ZWH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

96561:DOLE RS16620
gene id: 96561:DOLE_RS16620
uniprot id: A9A0B4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

96561:DOLE RS02065
gene id: 96561:DOLE_RS02065
uniprot id: A8ZTF7
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

96561:DOLE RS08610
gene id: 96561:DOLE_RS08610
uniprot id: A9A0I1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

96561:DOLE RS09105
gene id: 96561:DOLE_RS09105
uniprot id: A9A0V0
names: Similarity
messages: Belongs to the AOR/FOR family.

96561:DOLE RS00500
gene id: 96561:DOLE_RS00500
uniprot id: A8ZRZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

96561:DOLE RS14500
gene id: 96561:DOLE_RS14500
uniprot id: A8ZXZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

96561:DOLE RS12185
gene id: 96561:DOLE_RS12185
uniprot id: A8ZVJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

96561:DOLE RS00030
gene id: 96561:DOLE_RS00030
uniprot id: A8ZRP9
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

96561:DOLE RS05305
gene id: 96561:DOLE_RS05305
uniprot id: A8ZWY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS02840
gene id: 96561:DOLE_RS02840
uniprot id: A8ZU56
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

96561:DOLE RS09890
gene id: 96561:DOLE_RS09890
uniprot id: A8ZSJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

96561:DOLE RS14360
gene id: 96561:DOLE_RS14360
uniprot id: A8ZXW8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS11070
gene id: 96561:DOLE_RS11070
uniprot id: A8ZUC5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

96561:DOLE RS05460
gene id: 96561:DOLE_RS05460
uniprot id: A8ZX17
names: Similarity
messages: Belongs to the citrate synthase family.

96561:DOLE RS17165
gene id: 96561:DOLE_RS17165
uniprot id: A8ZY60
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

96561:DOLE RS10095
gene id: 96561:DOLE_RS10095
uniprot id: A8ZT89
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

96561:DOLE RS01895
gene id: 96561:DOLE_RS01895
uniprot id: A8ZT22
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

96561:DOLE RS07025
gene id: 96561:DOLE_RS07025
uniprot id: A8ZYR9
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS14780
gene id: 96561:DOLE_RS14780
uniprot id: A8ZYE9
names: Similarity
messages: Belongs to the peptidase M16 family.

96561:DOLE RS01805
gene id: 96561:DOLE_RS01805
uniprot id: A8ZT04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

96561:DOLE RS04000
gene id: 96561:DOLE_RS04000
uniprot id: A8ZVC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

96561:DOLE RS04925
gene id: 96561:DOLE_RS04925
uniprot id: A8ZWF9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

96561:DOLE RS14600
gene id: 96561:DOLE_RS14600
uniprot id: A8ZY12
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS13035
gene id: 96561:DOLE_RS13035
uniprot id: A8ZWL2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

96561:DOLE RS07310
gene id: 96561:DOLE_RS07310
uniprot id: A8ZYX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

96561:DOLE RS00480
gene id: 96561:DOLE_RS00480
uniprot id: A8ZRY9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS16015
gene id: 96561:DOLE_RS16015
uniprot id: A8ZZP4
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS13090
gene id: 96561:DOLE_RS13090
uniprot id: A8ZWM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

96561:DOLE RS13600
gene id: 96561:DOLE_RS13600
uniprot id: A8ZX73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

96561:DOLE RS12945
gene id: 96561:DOLE_RS12945
uniprot id: A8ZW92
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

96561:DOLE RS03050
gene id: 96561:DOLE_RS03050
uniprot id: A8ZU96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase B chain family.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

96561:DOLE RS14310
gene id: 96561:DOLE_RS14310
uniprot id: A8ZXV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

96561:DOLE RS14375
gene id: 96561:DOLE_RS14375
uniprot id: A8ZXX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

96561:DOLE RS04515
gene id: 96561:DOLE_RS04515
uniprot id: A8ZVX8
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

96561:DOLE RS07945
gene id: 96561:DOLE_RS07945
uniprot id: A8ZZU9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS10220
gene id: 96561:DOLE_RS10220
uniprot id: A8ZTB4
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS08245
gene id: 96561:DOLE_RS08245
uniprot id: A9A008
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS11610
gene id: 96561:DOLE_RS11610
uniprot id: A8ZUX2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS11055
gene id: 96561:DOLE_RS11055
uniprot id: A8ZUC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

96561:DOLE RS10460
gene id: 96561:DOLE_RS10460
uniprot id: A8ZTQ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

96561:DOLE RS00860
gene id: 96561:DOLE_RS00860
uniprot id: A8ZSR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

96561:DOLE RS09725
gene id: 96561:DOLE_RS09725
uniprot id: A8ZSG0
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

96561:DOLE RS15605
gene id: 96561:DOLE_RS15605
uniprot id: A8ZZ63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

96561:DOLE RS14005
gene id: 96561:DOLE_RS14005
uniprot id: A8ZXE8
names: Similarity
messages: Belongs to the HsdR family.

96561:DOLE RS10040
gene id: 96561:DOLE_RS10040
uniprot id: A8ZT78
names: Similarity
messages: Belongs to the UPF0251 family.

96561:DOLE RS14510
gene id: 96561:DOLE_RS14510
uniprot id: A8ZXZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

96561:DOLE RS10410
gene id: 96561:DOLE_RS10410
uniprot id: A8ZTF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

96561:DOLE RS06560
gene id: 96561:DOLE_RS06560
uniprot id: A8ZY79
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

96561:DOLE RS06990
gene id: 96561:DOLE_RS06990
uniprot id: A8ZYR2
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

96561:DOLE RS10445
gene id: 96561:DOLE_RS10445
uniprot id: A8ZTQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

96561:DOLE RS09535
gene id: 96561:DOLE_RS09535
uniprot id: A8ZSC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

96561:DOLE RS02720
gene id: 96561:DOLE_RS02720
uniprot id: A8ZU34
names: Similarity
messages: Belongs to the GSP E family.

96561:DOLE RS16125
gene id: 96561:DOLE_RS16125
uniprot id: A8ZZR5
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

96561:DOLE RS08110
gene id: 96561:DOLE_RS08110
uniprot id: A8ZZY1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

96561:DOLE RS00285
gene id: 96561:DOLE_RS00285
uniprot id: A8ZRV0
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

96561:DOLE RS03020
gene id: 96561:DOLE_RS03020
uniprot id: A8ZU90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

96561:DOLE RS16585
gene id: 96561:DOLE_RS16585
uniprot id: A9A0A8
names: Similarity
messages: Belongs to the UPF0111 family.

96561:DOLE RS13610
gene id: 96561:DOLE_RS13610
uniprot id: A8ZX75
names: Cofactor
messages: Binds 4 heme c groups covalently per monomer.

96561:DOLE RS09345
gene id: 96561:DOLE_RS09345
uniprot id: A9A0Z7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

96561:DOLE RS13825
gene id: 96561:DOLE_RS13825
uniprot id: A8ZXB6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

96561:DOLE RS08895
gene id: 96561:DOLE_RS08895
uniprot id: A9A0R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

96561:DOLE RS02890
gene id: 96561:DOLE_RS02890
uniprot id: A8ZU66
names: Similarity
messages: Belongs to the NAD synthetase family.

96561:DOLE RS06090
gene id: 96561:DOLE_RS06090
uniprot id: A8ZXN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

96561:DOLE RS05955
gene id: 96561:DOLE_RS05955
uniprot id: A8ZXL1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

96561:DOLE RS03745
gene id: 96561:DOLE_RS03745
uniprot id: A8ZV75
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

96561:DOLE RS08875
gene id: 96561:DOLE_RS08875
uniprot id: A9A0N1
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS01115
gene id: 96561:DOLE_RS01115
uniprot id: A8ZS16
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

96561:DOLE RS09500
gene id: 96561:DOLE_RS09500
uniprot id: A8ZSB5
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

96561:DOLE RS14815
gene id: 96561:DOLE_RS14815
uniprot id: A8ZYF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

96561:DOLE RS09810
gene id: 96561:DOLE_RS09810
uniprot id: A8ZSH9
names: Similarity
messages: Belongs to the YicC/YloC family.

96561:DOLE RS11600
gene id: 96561:DOLE_RS11600
uniprot id: A8ZUX0
names: Similarity
messages: Belongs to the universal stress protein A family.

96561:DOLE RS06890
gene id: 96561:DOLE_RS06890
uniprot id: A8ZYP2
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS14170
gene id: 96561:DOLE_RS14170
uniprot id: A8ZXT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS00505
gene id: 96561:DOLE_RS00505
uniprot id: A8ZRZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

96561:DOLE RS11000
gene id: 96561:DOLE_RS11000
uniprot id: A8ZUB3
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS05200
gene id: 96561:DOLE_RS05200
uniprot id: A8ZWW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

96561:DOLE RS01590
gene id: 96561:DOLE_RS01590
uniprot id: A8ZSW2
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

96561:DOLE RS01385
gene id: 96561:DOLE_RS01385
uniprot id: A8ZS70
names: Similarity
messages: Belongs to the HsdR family.

96561:DOLE RS07200
gene id: 96561:DOLE_RS07200
uniprot id: A8ZYV0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

96561:DOLE RS09255
gene id: 96561:DOLE_RS09255
uniprot id: A9A0Y0
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS08185
gene id: 96561:DOLE_RS08185
uniprot id: A8ZZZ6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS10170
gene id: 96561:DOLE_RS10170
uniprot id: A8ZTA4
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

96561:DOLE RS06105
gene id: 96561:DOLE_RS06105
uniprot id: A8ZXP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

96561:DOLE RS14940
gene id: 96561:DOLE_RS14940
uniprot id: A8ZYI2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS07260
gene id: 96561:DOLE_RS07260
uniprot id: A8ZYW2
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS10665
gene id: 96561:DOLE_RS10665
uniprot id: A8ZTU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

96561:DOLE RS11865
gene id: 96561:DOLE_RS11865
uniprot id: A8ZV23
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

96561:DOLE RS17100
gene id: 96561:DOLE_RS17100
uniprot id: A8ZX41
names: Similarity
messages: Belongs to the GSP E family.

96561:DOLE RS15780
gene id: 96561:DOLE_RS15780
uniprot id: A8ZZJ6
names: Subcellular Location Annotation
messages: Cytoplasm

96561:DOLE RS12135
gene id: 96561:DOLE_RS12135
uniprot id: A8ZVI2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

96561:DOLE RS13855
gene id: 96561:DOLE_RS13855
uniprot id: A8ZXC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

96561:DOLE RS02875
gene id: 96561:DOLE_RS02875
uniprot id: A8ZU63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

96561:DOLE RS10785
gene id: 96561:DOLE_RS10785
uniprot id: A8ZTW9
names: Similarity
messages: Belongs to the SfsA family.

96561:DOLE RS12570
gene id: 96561:DOLE_RS12570
uniprot id: A8ZW21
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane

96561:DOLE RS04235
gene id: 96561:DOLE_RS04235
uniprot id: A8ZVS3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

96561:DOLE RS00290
gene id: 96561:DOLE_RS00290
uniprot id: A8ZRV1
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

96561:DOLE RS10290
gene id: 96561:DOLE_RS10290
uniprot id: A8ZTC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

96561:DOLE RS04715
gene id: 96561:DOLE_RS04715
uniprot id: A8ZWB8
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS15725
gene id: 96561:DOLE_RS15725
uniprot id: A8ZZI5
names: Similarity
messages: Belongs to the YggT family.

96561:DOLE RS14490
gene id: 96561:DOLE_RS14490
uniprot id: A8ZXZ2
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

96561:DOLE RS15670
gene id: 96561:DOLE_RS15670
uniprot id: A8ZZH6
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

96561:DOLE RS15585
gene id: 96561:DOLE_RS15585
uniprot id: A8ZZ59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

96561:DOLE RS14635
gene id: 96561:DOLE_RS14635
uniprot id: A8ZYC1
names: Similarity
messages: Belongs to the Skp family.

96561:DOLE RS11855
gene id: 96561:DOLE_RS11855
uniprot id: A8ZV21
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

96561:DOLE RS02750
gene id: 96561:DOLE_RS02750
uniprot id: A8ZU40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

96561:DOLE RS11750
gene id: 96561:DOLE_RS11750
uniprot id: A8ZV00
names: Subcellular Location Annotation
messages: Cell surface

96561:DOLE RS14380
gene id: 96561:DOLE_RS14380
uniprot id: A8ZXX2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

96561:DOLE RS04180
gene id: 96561:DOLE_RS04180
uniprot id: A8ZVR2
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS15965
gene id: 96561:DOLE_RS15965
uniprot id: A8ZZN4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS12815
gene id: 96561:DOLE_RS12815
uniprot id: A8ZW67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

96561:DOLE RS00570
gene id: 96561:DOLE_RS00570
uniprot id: A8ZSL2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

96561:DOLE RS15715
gene id: 96561:DOLE_RS15715
uniprot id: A8ZZI3
names: Similarity
messages: Belongs to the GSP E family.

96561:DOLE RS00400
gene id: 96561:DOLE_RS00400
uniprot id: A8ZRX3
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

96561:DOLE RS03495
gene id: 96561:DOLE_RS03495
uniprot id: A8ZUS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

96561:DOLE RS04520
gene id: 96561:DOLE_RS04520
uniprot id: A8ZVX9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

96561:DOLE RS16345
gene id: 96561:DOLE_RS16345
uniprot id: A9A061
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS11375
gene id: 96561:DOLE_RS11375
uniprot id: A8ZUI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

96561:DOLE RS13445
gene id: 96561:DOLE_RS13445
uniprot id: A8ZWU0
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase involved in purine salvage.

96561:DOLE RS02080
gene id: 96561:DOLE_RS02080
uniprot id: A8ZTG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

96561:DOLE RS13250
gene id: 96561:DOLE_RS13250
uniprot id: A8ZWQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

96561:DOLE RS05315
gene id: 96561:DOLE_RS05315
uniprot id: A8ZWY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP I family.
messages: Membrane

96561:DOLE RS02410
gene id: 96561:DOLE_RS02410
uniprot id: A8ZTM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

96561:DOLE RS11575
gene id: 96561:DOLE_RS11575
uniprot id: A8ZUW4
names: Cofactor
messages: Binds 4 heme c groups covalently per monomer.

96561:DOLE RS12740
gene id: 96561:DOLE_RS12740
uniprot id: A8ZW52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

96561:DOLE RS04945
gene id: 96561:DOLE_RS04945
uniprot id: A8ZWG3
names: Function
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.

96561:DOLE RS10960
gene id: 96561:DOLE_RS10960
uniprot id: A8ZU04
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

96561:DOLE RS11930
gene id: 96561:DOLE_RS11930
uniprot id: A8ZV37
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

96561:DOLE RS00210
gene id: 96561:DOLE_RS00210
uniprot id: A8ZRT4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

96561:DOLE RS05195
gene id: 96561:DOLE_RS05195
uniprot id: A8ZWW5
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

96561:DOLE RS04305
gene id: 96561:DOLE_RS04305
uniprot id: A8ZVT6
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS10210
gene id: 96561:DOLE_RS10210
uniprot id: A8ZTB2
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

96561:DOLE RS02270
gene id: 96561:DOLE_RS02270
uniprot id: A8ZTJ6
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS06020
gene id: 96561:DOLE_RS06020
uniprot id: A8ZXM3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

96561:DOLE RS13225
gene id: 96561:DOLE_RS13225
uniprot id: A8ZWP9
names: Similarity
messages: Belongs to the histone deacetylase family.

96561:DOLE RS14555
gene id: 96561:DOLE_RS14555
uniprot id: A8ZY04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

96561:DOLE RS10130
gene id: 96561:DOLE_RS10130
uniprot id: A8ZT96
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS05350
gene id: 96561:DOLE_RS05350
uniprot id: A8ZWZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane

96561:DOLE RS16525
gene id: 96561:DOLE_RS16525
uniprot id: A9A096
names: Similarity
messages: Belongs to the UbiD family.

96561:DOLE RS01500
gene id: 96561:DOLE_RS01500
uniprot id: A8ZS90
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

96561:DOLE RS04335
gene id: 96561:DOLE_RS04335
uniprot id: A8ZVU2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

96561:DOLE RS16475
gene id: 96561:DOLE_RS16475
uniprot id: A9A087
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

96561:DOLE RS12960
gene id: 96561:DOLE_RS12960
uniprot id: A8ZW95
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

96561:DOLE RS15750
gene id: 96561:DOLE_RS15750
uniprot id: A8ZZJ0
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

96561:DOLE RS11080
gene id: 96561:DOLE_RS11080
uniprot id: A8ZUC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

96561:DOLE RS16610
gene id: 96561:DOLE_RS16610
uniprot id: A9A0B2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form.

96561:DOLE RS06805
gene id: 96561:DOLE_RS06805
uniprot id: A8ZYM5
names: Similarity
messages: Belongs to the TPP enzyme family.

96561:DOLE RS11680
gene id: 96561:DOLE_RS11680
uniprot id: A8ZUY6
names: Similarity
messages: Belongs to the glutamine synthetase family.

96561:DOLE RS05300
gene id: 96561:DOLE_RS05300
uniprot id: A8ZWY5
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

96561:DOLE RS10485
gene id: 96561:DOLE_RS10485
uniprot id: A8ZTR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

96561:DOLE RS12495
gene id: 96561:DOLE_RS12495
uniprot id: A8ZVQ3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

96561:DOLE RS16275
gene id: 96561:DOLE_RS16275
uniprot id: A9A047
names: Similarity
messages: Belongs to the histone deacetylase family.

96561:DOLE RS15640
gene id: 96561:DOLE_RS15640
uniprot id: A8ZZ69
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

96561:DOLE RS14620
gene id: 96561:DOLE_RS14620
uniprot id: A8ZY16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

96561:DOLE RS06375
gene id: 96561:DOLE_RS06375
uniprot id: A8ZY43
names: Similarity
messages: Belongs to the GSP E family.

96561:DOLE RS09040
gene id: 96561:DOLE_RS09040
uniprot id: A9A0T7
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

96561:DOLE RS11075
gene id: 96561:DOLE_RS11075
uniprot id: A8ZUC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

96561:DOLE RS09445
gene id: 96561:DOLE_RS09445
uniprot id: A8ZSA5
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS01930
gene id: 96561:DOLE_RS01930
uniprot id: A8ZT29
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

96561:DOLE RS14215
gene id: 96561:DOLE_RS14215
uniprot id: A8ZXU1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

96561:DOLE RS15995
gene id: 96561:DOLE_RS15995
uniprot id: A8ZZP0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

96561:DOLE RS02905
gene id: 96561:DOLE_RS02905
uniprot id: A8ZU68
names: Similarity
messages: Belongs to the UPF0047 family.

96561:DOLE RS03750
gene id: 96561:DOLE_RS03750
uniprot id: A8ZV76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

96561:DOLE RS11835
gene id: 96561:DOLE_RS11835
uniprot id: A8ZV17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

96561:DOLE RS04300
gene id: 96561:DOLE_RS04300
uniprot id: A8ZVT5
names: Subcellular Location Annotation
messages: Membrane

96561:DOLE RS04365
gene id: 96561:DOLE_RS04365
uniprot id: A8ZVU8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

96561:DOLE RS03100
gene id: 96561:DOLE_RS03100
uniprot id: A8ZUA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

96561:DOLE RS03455
gene id: 96561:DOLE_RS03455
uniprot id: A8ZUR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.