9646:LOC100474917
gene id: 9646:LOC100474917
uniprot id: D2HVS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9646:KPNA6
gene id: 9646:KPNA6
uniprot id: G1LMT1
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9646:LOC100480317
gene id: 9646:LOC100480317
uniprot id: D2H2C9
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9646:GINS2
gene id: 9646:GINS2
uniprot id: D2GWN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Nucleus

9646:PSMB3
gene id: 9646:PSMB3
uniprot id: G1LCI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9646:PLA2G3
gene id: 9646:PLA2G3
uniprot id: D2H207
uniprot id: G1LKV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9646:ACSS2
gene id: 9646:ACSS2
uniprot id: G1LRW3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9646:TADA3
gene id: 9646:TADA3
uniprot id: D2HRA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

9646:FBN1
gene id: 9646:FBN1
uniprot id: G1L4Y3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9646:SRP19
gene id: 9646:SRP19
uniprot id: A0A7N5KCS8
uniprot id: G1M1S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

9646:TRAPPC2L
gene id: 9646:TRAPPC2L
uniprot id: G1L0B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9646:SERPINI1
gene id: 9646:SERPINI1
uniprot id: A0A7N5P375
names: Similarity
messages: Belongs to the serpin family.

9646:PIGU
gene id: 9646:PIGU
uniprot id: G1LRI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:TRIT1
gene id: 9646:TRIT1
uniprot id: A0A7N5P1B0
names: Similarity
messages: Belongs to the IPP transferase family.

9646:QSOX1
gene id: 9646:QSOX1
uniprot id: D2HFH1
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

9646:ACOX2
gene id: 9646:ACOX2
uniprot id: G1M082
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9646:STOML2
gene id: 9646:STOML2
uniprot id: D2I1Z7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9646:RIOK3
gene id: 9646:RIOK3
uniprot id: A0A7N5K3E3
uniprot id: G1M591
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.

9646:SEPTIN3
gene id: 9646:SEPTIN3
uniprot id: G1LS35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9646:FAM83C
gene id: 9646:FAM83C
uniprot id: D2H448
names: Similarity
messages: Belongs to the FAM83 family.

9646:TIPARP
gene id: 9646:TIPARP
uniprot id: D2HJI0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9646:DYNLRB1
gene id: 9646:DYNLRB1
uniprot id: G1LRF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9646:ELMO2
gene id: 9646:ELMO2
uniprot id: D2I5V9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9646:CENPL
gene id: 9646:CENPL
uniprot id: G1MAT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

9646:UBAC2
gene id: 9646:UBAC2
uniprot id: G1LCL4
names: Subcellular Location Annotation
messages: Membrane

9646:DDX58
gene id: 9646:DDX58
uniprot id: D2HZI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9646:BPNT1
gene id: 9646:BPNT1
uniprot id: G1LU04
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9646:ATP6V0D1
gene id: 9646:ATP6V0D1
uniprot id: D2H9E6
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

9646:YIPF6
gene id: 9646:YIPF6
uniprot id: A0A7N5P576
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:LOC100468187
gene id: 9646:LOC100468187
uniprot id: D2HUT4
names: Similarity
messages: Belongs to the serpin family.

9646:SLC30A9
gene id: 9646:SLC30A9
uniprot id: G1M2Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

9646:LOC100466214
gene id: 9646:LOC100466214
uniprot id: D2I7B4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ELK4
gene id: 9646:ELK4
uniprot id: D2H8T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:ARAP3
gene id: 9646:ARAP3
uniprot id: D2GUL8
names: Subcellular Location Annotation
messages: Cytoplasm

9646:MLST8
gene id: 9646:MLST8
uniprot id: G1MHK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9646:CCDC39
gene id: 9646:CCDC39
uniprot id: G1LX10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC39 family.
messages: cilium axoneme

9646:FAM98A
gene id: 9646:FAM98A
uniprot id: A0A7N5JYR6
names: Similarity
messages: Belongs to the FAM98 family.

9646:USP30
gene id: 9646:USP30
uniprot id: G1MDL8
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9646:OSBPL7
gene id: 9646:OSBPL7
uniprot id: D2H549
names: Similarity
messages: Belongs to the OSBP family.

9646:EPDR1
gene id: 9646:EPDR1
uniprot id: A0A7N5JG37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ependymin family.
messages: Binds anionic lipids and gangliosides at acidic pH.
messages: Lysosome lumen

9646:FUT11
gene id: 9646:FUT11
uniprot id: G1MEE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9646:SEC11C
gene id: 9646:SEC11C
uniprot id: G1M9R6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:LOC100478996
gene id: 9646:LOC100478996
uniprot id: G1LMC8
names: Similarity
messages: Belongs to the Tango6 family.

9646:LOC100468223
gene id: 9646:LOC100468223
uniprot id: G1LL82
names: Subcellular Location Annotation
messages: Membrane

9646:CD3G
gene id: 9646:CD3G
uniprot id: G1M3D4
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Membrane
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.

9646:EPHB4
gene id: 9646:EPHB4
uniprot id: A0A7N5KBM2
names: Subcellular Location Annotation
messages: Membrane

9646:ADPRHL1
gene id: 9646:ADPRHL1
uniprot id: D2HTS3
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9646:ST3GAL2
gene id: 9646:ST3GAL2
uniprot id: D2HFV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9646:TNFAIP1
gene id: 9646:TNFAIP1
uniprot id: D2GU42
names: Similarity
messages: Belongs to the BACURD family.

9646:TAS2R38
gene id: 9646:TAS2R38
uniprot id: G1M985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9646:PSMC4
gene id: 9646:PSMC4
uniprot id: G1M1U5
names: Similarity
messages: Belongs to the AAA ATPase family.

9646:ERI1
gene id: 9646:ERI1
uniprot id: G1MC25
names: Subcellular Location Annotation
messages: Cytoplasm

9646:REXO4
gene id: 9646:REXO4
uniprot id: G1LYU7
names: Similarity
messages: Belongs to the REXO4 family.

9646:STEAP2
gene id: 9646:STEAP2
uniprot id: D2HE08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9646:SNTA1
gene id: 9646:SNTA1
uniprot id: D2H8Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9646:ATL1
gene id: 9646:ATL1
uniprot id: G1LTT3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9646:SPDEF
gene id: 9646:SPDEF
uniprot id: D2GYX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:CALHM4
gene id: 9646:CALHM4
uniprot id: D2HNV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9646:CD28
gene id: 9646:CD28
uniprot id: G1L897
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100477689
gene id: 9646:LOC100477689
uniprot id: D2I5Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TMEM208
gene id: 9646:TMEM208
uniprot id: G1MG15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9646:TRPT1
gene id: 9646:TRPT1
uniprot id: D2H4U4
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

9646:CXCL9
gene id: 9646:CXCL9
uniprot id: A0A7N5K754
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9646:LOC100467946
gene id: 9646:LOC100467946
uniprot id: A0A7N5JI02
uniprot id: D2HXQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9646:RNF5
gene id: 9646:RNF5
uniprot id: D2I367
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

9646:RPL10
gene id: 9646:RPL10
uniprot id: D3YC00
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9646:MINDY4
gene id: 9646:MINDY4
uniprot id: G1LJI6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9646:IBSP
gene id: 9646:IBSP
uniprot id: D2GX57
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9646:LPCAT4
gene id: 9646:LPCAT4
uniprot id: D2I547
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9646:LOC100464112
gene id: 9646:LOC100464112
uniprot id: D2HWJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:CHRM2
gene id: 9646:CHRM2
uniprot id: D2GYP2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9646:PPP1R14B
gene id: 9646:PPP1R14B
uniprot id: A0A7N5P2C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9646:RNF40
gene id: 9646:RNF40
uniprot id: D2HQN6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9646:SEC24C
gene id: 9646:SEC24C
uniprot id: D2HEF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9646:SLC2A1
gene id: 9646:SLC2A1
uniprot id: G1L5P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane
messages: Photoreceptor inner segment

9646:LOC100465962
gene id: 9646:LOC100465962
uniprot id: D2I6R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:SLC16A4
gene id: 9646:SLC16A4
uniprot id: G1LYG9
names: Subcellular Location Annotation
messages: Membrane

9646:CDH7
gene id: 9646:CDH7
uniprot id: D2HQX2
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9646:C3H5orf24
gene id: 9646:C3H5orf24
uniprot id: D2GVJ9
names: Similarity
messages: Belongs to the UPF0461 family.

9646:RAB3A
gene id: 9646:RAB3A
uniprot id: D2GV26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9646:ELOVL5
gene id: 9646:ELOVL5
uniprot id: G1LGM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: dendrite

9646:PSMA5
gene id: 9646:PSMA5
uniprot id: G1LDQ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9646:TACR2
gene id: 9646:TACR2
uniprot id: G1MHU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:LOC100474670
gene id: 9646:LOC100474670
uniprot id: G1MN55
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:IP6K1
gene id: 9646:IP6K1
uniprot id: D2HEU2
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9646:LOC100472203
gene id: 9646:LOC100472203
uniprot id: D2HU47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:PLAT
gene id: 9646:PLAT
uniprot id: G1LFI3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:ALLC
gene id: 9646:ALLC
uniprot id: G1MJF8
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

9646:MSRA
gene id: 9646:MSRA
uniprot id: A0A7N5KKV0
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

9646:LOC100471980
gene id: 9646:LOC100471980
uniprot id: D2I6T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ATPAF2
gene id: 9646:ATPAF2
uniprot id: A0A7N5P5K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9646:VTA1
gene id: 9646:VTA1
uniprot id: D2GUS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9646:TRAPPC5
gene id: 9646:TRAPPC5
uniprot id: D2HI87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9646:DAZL
gene id: 9646:DAZL
uniprot id: A0A7N5K1Y5
names: Subcellular Location Annotation
messages: Cytoplasm

9646:DCTN5
gene id: 9646:DCTN5
uniprot id: A0A7N5KKG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

9646:FAM171A1
gene id: 9646:FAM171A1
uniprot id: A0A7N5KIM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

9646:NPPA
gene id: 9646:NPPA
uniprot id: G1LTH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney.
messages: May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

9646:IGFBP4
gene id: 9646:IGFBP4
uniprot id: D2HR23
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:LCN2
gene id: 9646:LCN2
uniprot id: G1M9R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9646:NDUFS2
gene id: 9646:NDUFS2
uniprot id: A0A7N5JDT2
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

9646:PLA2G12A
gene id: 9646:PLA2G12A
uniprot id: D2I2D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9646:LOC100476410
gene id: 9646:LOC100476410
uniprot id: G1M598
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

9646:NUP50
gene id: 9646:NUP50
uniprot id: G1LR55
names: Subcellular Location Annotation
messages: nuclear pore complex

9646:OSGEPL1
gene id: 9646:OSGEPL1
uniprot id: G1M0Q0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Mitochondrion
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9646:VSIG1
gene id: 9646:VSIG1
uniprot id: G1L803
names: Subcellular Location Annotation
messages: Membrane

9646:SPC24
gene id: 9646:SPC24
uniprot id: G1LWB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9646:FAM187A
gene id: 9646:FAM187A
uniprot id: G1MNN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9646:YEATS4
gene id: 9646:YEATS4
uniprot id: A0A7N5J9P1
uniprot id: G1LZE9
names: Subcellular Location Annotation
messages: Nucleus

9646:SLC6A6
gene id: 9646:SLC6A6
uniprot id: A0A7N5JZA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

9646:MTMR2
gene id: 9646:MTMR2
uniprot id: G1LN07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9646:HEATR1
gene id: 9646:HEATR1
uniprot id: D2I0E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9646:GDPD5
gene id: 9646:GDPD5
uniprot id: D2H1D1
uniprot id: G1MF72
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9646:ZIC3
gene id: 9646:ZIC3
uniprot id: D2HD88
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9646:CLRN1
gene id: 9646:CLRN1
uniprot id: D2H3Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9646:CCN4
gene id: 9646:CCN4
uniprot id: A0A7N5K7E9
names: Caution
names: Similarity
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:KDM3A
gene id: 9646:KDM3A
uniprot id: G1LTS0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9646:LOC100484357
gene id: 9646:LOC100484357
uniprot id: A0A7N5P8J2
uniprot id: G1LJW6
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

9646:LOC100469028
gene id: 9646:LOC100469028
uniprot id: G1MJL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:HSD3B7
gene id: 9646:HSD3B7
uniprot id: G1LLV7
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9646:AZGP1
gene id: 9646:AZGP1
uniprot id: A0A7N5JYI2
names: Similarity
messages: Belongs to the MHC class I family.

9646:GRM1
gene id: 9646:GRM1
uniprot id: G1LHF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9646:SLC45A2
gene id: 9646:SLC45A2
uniprot id: D2HC23
names: Subcellular Location Annotation
messages: Membrane

9646:CRCP
gene id: 9646:CRCP
uniprot id: A0A7N5KMX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9646:TBK1
gene id: 9646:TBK1
uniprot id: A0A7N5J866
names: Subcellular Location Annotation
messages: Cytoplasm

9646:TFIP11
gene id: 9646:TFIP11
uniprot id: D2HKD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9646:CLDN5
gene id: 9646:CLDN5
uniprot id: D2HEY1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9646:KCNB1
gene id: 9646:KCNB1
uniprot id: D2GVP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: dendrite
messages: sarcolemma
messages: synaptosome

9646:MED22
gene id: 9646:MED22
uniprot id: G1LZ20
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9646:ARMC1
gene id: 9646:ARMC1
uniprot id: D2H415
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

9646:PSMD13
gene id: 9646:PSMD13
uniprot id: D2I616
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9646:GFOD2
gene id: 9646:GFOD2
uniprot id: D2H9F4
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9646:DEDD2
gene id: 9646:DEDD2
uniprot id: D2HNG8
names: Subcellular Location Annotation
messages: nucleolus

9646:HVCN1
gene id: 9646:HVCN1
uniprot id: A0A7N5JFA7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9646:PAPSS1
gene id: 9646:PAPSS1
uniprot id: G1L586
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9646:FZD3
gene id: 9646:FZD3
uniprot id: D2HAJ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:EMC8
gene id: 9646:EMC8
uniprot id: D2GWN5
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9646:PRL
gene id: 9646:PRL
uniprot id: Q8HXS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the somatotropin/prolactin family.
messages: Interacts with PRLR.
messages: Prolactin acts primarily on the mammary gland by promoting lactation.
messages: Secreted

9646:SURF6
gene id: 9646:SURF6
uniprot id: G1LZ28
names: Similarity
messages: Belongs to the SURF6 family.

9646:VWC2L
gene id: 9646:VWC2L
uniprot id: G1LAX2
names: Subcellular Location Annotation
messages: Synapse

9646:MYO5C
gene id: 9646:MYO5C
uniprot id: G1LKY6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9646:RPL21
gene id: 9646:RPL21
uniprot id: F2X260
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9646:KIF15
gene id: 9646:KIF15
uniprot id: G1M062
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.
messages: spindle

9646:ELMO3
gene id: 9646:ELMO3
uniprot id: G1MG03
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9646:PSMB10
gene id: 9646:PSMB10
uniprot id: G1MGU2
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100476268
gene id: 9646:LOC100476268
uniprot id: G1MMP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ABCA9
gene id: 9646:ABCA9
uniprot id: D2HSX8
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100468610
gene id: 9646:LOC100468610
uniprot id: D2HNJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CMC4
gene id: 9646:CMC4
uniprot id: G1LZR9
names: Similarity
messages: Belongs to the CMC4 family.

9646:GPRC6A
gene id: 9646:GPRC6A
uniprot id: A0A7N5P2X9
uniprot id: D2HNW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:MSR1
gene id: 9646:MSR1
uniprot id: D2I0F6
names: Subcellular Location Annotation
messages: Membrane

9646:APEX1
gene id: 9646:APEX1
uniprot id: D2I2U8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9646:CEP55
gene id: 9646:CEP55
uniprot id: D2H3D1
names: Subcellular Location Annotation
messages: Cytoplasm

9646:CD151
gene id: 9646:CD151
uniprot id: D2I6I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9646:LASP1
gene id: 9646:LASP1
uniprot id: A0A7N5KS11
uniprot id: D2H536
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

9646:UBE2E1
gene id: 9646:UBE2E1
uniprot id: D2HKU5
uniprot id: G1L9Y1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9646:LOC100471390
gene id: 9646:LOC100471390
uniprot id: D2HUM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9646:IL18
gene id: 9646:IL18
uniprot id: T2C4C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted

9646:NDUFB10
gene id: 9646:NDUFB10
uniprot id: D2HE03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

9646:UBE2T
gene id: 9646:UBE2T
uniprot id: G1LZJ5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9646:POLA1
gene id: 9646:POLA1
uniprot id: G1M8F8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

9646:LOC100464625
gene id: 9646:LOC100464625
uniprot id: G1LEG0
names: Similarity
messages: Belongs to the cornifelin family.

9646:ATP6V0E1
gene id: 9646:ATP6V0E1
uniprot id: D2H5F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane

9646:GNGT2
gene id: 9646:GNGT2
uniprot id: D2H579
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9646:TSPAN3
gene id: 9646:TSPAN3
uniprot id: G1LT39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9646:HOXC6
gene id: 9646:HOXC6
uniprot id: D2HM46
names: Subcellular Location Annotation
messages: Nucleus

9646:UNC119
gene id: 9646:UNC119
uniprot id: A0A7N5JE75
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9646:LOC100468044
gene id: 9646:LOC100468044
uniprot id: A0A7N5P8I9
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9646:FSHB
gene id: 9646:FSHB
uniprot id: D2HUC2
uniprot id: Q8WN19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.
messages: Secreted
messages: Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.

9646:SLC30A2
gene id: 9646:SLC30A2
uniprot id: G1LV00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9646:LOC109489291
gene id: 9646:LOC109489291
uniprot id: D2H5W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9646:RAD21
gene id: 9646:RAD21
uniprot id: D2HZV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9646:USP39
gene id: 9646:USP39
uniprot id: G1L6A4
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100470304
gene id: 9646:LOC100470304
uniprot id: A0A7N5KL41
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9646:LOC109488460
gene id: 9646:LOC109488460
uniprot id: D2I4Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:KCTD20
gene id: 9646:KCTD20
uniprot id: D2GYV4
names: Subcellular Location Annotation
messages: Cytoplasm

9646:LOC100472672
gene id: 9646:LOC100472672
uniprot id: G1LD28
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9646:ZNF277
gene id: 9646:ZNF277
uniprot id: G1LGG7
names: Similarity
messages: Belongs to the ZNF277 family.

9646:ASPDH
gene id: 9646:ASPDH
uniprot id: G1M2T6
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9646:GRM8
gene id: 9646:GRM8
uniprot id: G1LD81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9646:PDE6D
gene id: 9646:PDE6D
uniprot id: G1MCW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9646:LOC100473113
gene id: 9646:LOC100473113
uniprot id: G1M620
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:LSM5
gene id: 9646:LSM5
uniprot id: A0A7N5K1Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9646:TLR5
gene id: 9646:TLR5
uniprot id: D2HJD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9646:DYNLL2
gene id: 9646:DYNLL2
uniprot id: D2H256
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9646:TCTN3
gene id: 9646:TCTN3
uniprot id: G1MBW5
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9646:CGA
gene id: 9646:CGA
uniprot id: G1LYF7
uniprot id: Q8WN20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9646:ATF7IP2
gene id: 9646:ATF7IP2
uniprot id: G1M8L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9646:NFKB1
gene id: 9646:NFKB1
uniprot id: G1LQS1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:LOC100473570
gene id: 9646:LOC100473570
uniprot id: A0A7N5K5K2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9646:LOC100481277
gene id: 9646:LOC100481277
uniprot id: G1MLF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TMEM256
gene id: 9646:TMEM256
uniprot id: G1ME39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9646:SNRPG
gene id: 9646:SNRPG
uniprot id: G1MC08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9646:LOC100482795
gene id: 9646:LOC100482795
uniprot id: G1MN63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9646:MUS81
gene id: 9646:MUS81
uniprot id: G1MG23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

9646:ADCY3
gene id: 9646:ADCY3
uniprot id: D2GXP9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Membrane

9646:PPP1R3B
gene id: 9646:PPP1R3B
uniprot id: D2I1W2
uniprot id: G1MNS0
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9646:HINT1
gene id: 9646:HINT1
uniprot id: D2HVN8
names: Similarity
messages: Belongs to the HINT family.

9646:ANXA13
gene id: 9646:ANXA13
uniprot id: A0A7N5KLK1
uniprot id: G1LXJ9
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9646:TAT
gene id: 9646:TAT
uniprot id: D2HFW4
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

9646:SEH1L
gene id: 9646:SEH1L
uniprot id: D2HKN7
uniprot id: G1MHC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

9646:SPOP
gene id: 9646:SPOP
uniprot id: D2HMY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9646:MRPL35
gene id: 9646:MRPL35
uniprot id: A0A7N5JHG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9646:OCIAD1
gene id: 9646:OCIAD1
uniprot id: G1LNP7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

9646:LCK
gene id: 9646:LCK
uniprot id: G1LMD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9646:MAK16
gene id: 9646:MAK16
uniprot id: G1L801
names: Similarity
messages: Belongs to the MAK16 family.

9646:PIWIL1
gene id: 9646:PIWIL1
uniprot id: A0A7N5JP18
uniprot id: D2HWM8
names: Similarity
messages: Belongs to the argonaute family.

9646:SOSTDC1
gene id: 9646:SOSTDC1
uniprot id: A0A7N5KQG4
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:LIPM
gene id: 9646:LIPM
uniprot id: G1L1Y9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9646:LOC100475926
gene id: 9646:LOC100475926
uniprot id: D2I565
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:RRS1
gene id: 9646:RRS1
uniprot id: D2H419
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9646:ARF6
gene id: 9646:ARF6
uniprot id: D2HIE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

9646:ASCC3
gene id: 9646:ASCC3
uniprot id: D2HIC5
names: Similarity
messages: Belongs to the helicase family.

9646:LOC100465427
gene id: 9646:LOC100465427
uniprot id: A0A7N5JNU6
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9646:ACKR1
gene id: 9646:ACKR1
uniprot id: A0A7N5KAN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Membrane
messages: Recycling endosome

9646:PDCD4
gene id: 9646:PDCD4
uniprot id: A0A7N5JG17
names: Similarity
messages: Belongs to the PDCD4 family.

9646:PTGER4
gene id: 9646:PTGER4
uniprot id: D2HJX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9646:GSDMA
gene id: 9646:GSDMA
uniprot id: A0A7N5K1R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9646:MTIF2
gene id: 9646:MTIF2
uniprot id: D2GY80
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

9646:HSD17B3
gene id: 9646:HSD17B3
uniprot id: A0A7N5K4E2
uniprot id: A0A7N5KLQ4
uniprot id: A0A7N5P9D1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:ST6GALNAC3
gene id: 9646:ST6GALNAC3
uniprot id: G1LAB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9646:ADH5
gene id: 9646:ADH5
uniprot id: G1M5T4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

9646:PAX5
gene id: 9646:PAX5
uniprot id: G1LU97
names: Subcellular Location Annotation
messages: Nucleus

9646:GNGT1
gene id: 9646:GNGT1
uniprot id: D2H8V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9646:CALR3
gene id: 9646:CALR3
uniprot id: D2GUZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9646:ELOVL6
gene id: 9646:ELOVL6
uniprot id: D2H706
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

9646:RPA2
gene id: 9646:RPA2
uniprot id: G1LXA5
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

9646:LAMTOR5
gene id: 9646:LAMTOR5
uniprot id: A0A7N5K0Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

9646:LOC100472383
gene id: 9646:LOC100472383
uniprot id: D2HT44
names: Similarity
messages: Belongs to the actin family.

9646:MYOD1
gene id: 9646:MYOD1
uniprot id: D2I0V4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9646:PSME3IP1
gene id: 9646:PSME3IP1
uniprot id: A0A7N5JF08
names: Subcellular Location Annotation
messages: Nucleus

9646:TARDBP
gene id: 9646:TARDBP
uniprot id: D2HKA5
names: Subcellular Location Annotation
messages: Nucleus

9646:PRPH2
gene id: 9646:PRPH2
uniprot id: D2GZE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9646:ST6GALNAC4
gene id: 9646:ST6GALNAC4
uniprot id: G1M9I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9646:CAPN2
gene id: 9646:CAPN2
uniprot id: A0A7N5KEN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9646:RPS29
gene id: 9646:RPS29
uniprot id: F2X227
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9646:RNGTT
gene id: 9646:RNGTT
uniprot id: G1L0L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

9646:SLC25A3
gene id: 9646:SLC25A3
uniprot id: A0A7N5KC34
uniprot id: D2HE44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9646:PSMC1
gene id: 9646:PSMC1
uniprot id: A0A7N5J9R3
names: Similarity
messages: Belongs to the AAA ATPase family.

9646:LOC100480394
gene id: 9646:LOC100480394
uniprot id: A0A7N5JJE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:EXTL1
gene id: 9646:EXTL1
uniprot id: D2GWF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:ALOX5AP
gene id: 9646:ALOX5AP
uniprot id: A0A7N5JHE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:TAF8
gene id: 9646:TAF8
uniprot id: G1M2Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

9646:LOC100463816
gene id: 9646:LOC100463816
uniprot id: G1LHT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9646:HAPLN1
gene id: 9646:HAPLN1
uniprot id: G1LLU8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9646:PROX1
gene id: 9646:PROX1
uniprot id: G1MBC1
names: Subcellular Location Annotation
messages: Nucleus

9646:LCAT
gene id: 9646:LCAT
uniprot id: A0A7N5JCH2
uniprot id: A0A7N5P0Z6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9646:NOP58
gene id: 9646:NOP58
uniprot id: G1M3K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9646:TJP2
gene id: 9646:TJP2
uniprot id: A0A7N5JM83
uniprot id: A0A7N5KNU0
uniprot id: G1LK83
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9646:SLC33A1
gene id: 9646:SLC33A1
uniprot id: D2HT98
names: Subcellular Location Annotation
messages: Membrane

9646:PGAP3
gene id: 9646:PGAP3
uniprot id: D2I2F9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:LOC100470585
gene id: 9646:LOC100470585
uniprot id: A0A7N5P8B3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9646:TRMT1
gene id: 9646:TRMT1
uniprot id: G1M1S7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

9646:SVOPL
gene id: 9646:SVOPL
uniprot id: G1MI25
names: Subcellular Location Annotation
messages: Membrane

9646:KATNAL2
gene id: 9646:KATNAL2
uniprot id: G1M2A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

9646:RRP1
gene id: 9646:RRP1
uniprot id: G1LYA4
names: Similarity
messages: Belongs to the RRP1 family.

9646:TAX1BP3
gene id: 9646:TAX1BP3
uniprot id: G1LRM9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9646:DAP3
gene id: 9646:DAP3
uniprot id: G1KZJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

9646:PHOSPHO2
gene id: 9646:PHOSPHO2
uniprot id: D2H4C7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9646:EID1
gene id: 9646:EID1
uniprot id: G1MLU6
names: Subcellular Location Annotation
messages: Nucleus

9646:BORCS8
gene id: 9646:BORCS8
uniprot id: G1LYY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

9646:SLC17A4
gene id: 9646:SLC17A4
uniprot id: G1LTU4
names: Subcellular Location Annotation
messages: Membrane

9646:ATP2A2
gene id: 9646:ATP2A2
uniprot id: G1M646
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9646:ZW10
gene id: 9646:ZW10
uniprot id: D2HZX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

9646:ZDHHC4
gene id: 9646:ZDHHC4
uniprot id: G1LJG0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9646:SLC22A5
gene id: 9646:SLC22A5
uniprot id: D2GVH3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9646:TOMM40L
gene id: 9646:TOMM40L
uniprot id: D2I0S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9646:LOC100483805
gene id: 9646:LOC100483805
uniprot id: D2I6C4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:UCN3
gene id: 9646:UCN3
uniprot id: D2HEB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9646:CLK4
gene id: 9646:CLK4
uniprot id: D2HGD2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:LOC100476603
gene id: 9646:LOC100476603
uniprot id: G1MPD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CHRNA1
gene id: 9646:CHRNA1
uniprot id: G1M0T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:USP48
gene id: 9646:USP48
uniprot id: A0A7N5KCA6
uniprot id: G1M752
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

9646:TMEM150C
gene id: 9646:TMEM150C
uniprot id: D2GUF3
names: Subcellular Location Annotation
messages: Membrane

9646:RSPO2
gene id: 9646:RSPO2
uniprot id: G1M298
names: Similarity
messages: Belongs to the R-spondin family.

9646:LOC100481084
gene id: 9646:LOC100481084
uniprot id: A0A7N5JNH5
uniprot id: D2H835
uniprot id: G1MCM1
uniprot id: G1MCM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9646:ATP9B
gene id: 9646:ATP9B
uniprot id: G1LUR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9646:LANCL1
gene id: 9646:LANCL1
uniprot id: G1LEM2
names: Similarity
messages: Belongs to the LanC-like protein family.

9646:MYO1A
gene id: 9646:MYO1A
uniprot id: D2H372
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9646:HSF2
gene id: 9646:HSF2
uniprot id: A0A7N5JIB3
uniprot id: D2HCP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9646:CTSE
gene id: 9646:CTSE
uniprot id: G1M264
names: Similarity
messages: Belongs to the peptidase A1 family.

9646:NMNAT1
gene id: 9646:NMNAT1
uniprot id: D2HA35
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9646:IL1RAP
gene id: 9646:IL1RAP
uniprot id: A0A7N5JIH0
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9646:AWAT1
gene id: 9646:AWAT1
uniprot id: G1LRB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9646:NUP62
gene id: 9646:NUP62
uniprot id: D2H7U0
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

9646:SEC22B
gene id: 9646:SEC22B
uniprot id: G1LZ42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9646:MAPK1IP1L
gene id: 9646:MAPK1IP1L
uniprot id: G1LKH2
names: Similarity
messages: Belongs to the MISS family.

9646:FGF10
gene id: 9646:FGF10
uniprot id: D2HSJ5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9646:AMIGO2
gene id: 9646:AMIGO2
uniprot id: D2HJ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Cell membrane
messages: Membrane

9646:IMMP1L
gene id: 9646:IMMP1L
uniprot id: G1LJZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9646:PREPL
gene id: 9646:PREPL
uniprot id: D2GU97
names: Similarity
messages: Belongs to the peptidase S9A family.

9646:CA8
gene id: 9646:CA8
uniprot id: A0A7N5P2J9
uniprot id: G1LGX2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9646:B9D1
gene id: 9646:B9D1
uniprot id: A0A7N5KF30
names: Subcellular Location Annotation
messages: cilium basal body

9646:BABAM1
gene id: 9646:BABAM1
uniprot id: G1LV77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

9646:POLR1C
gene id: 9646:POLR1C
uniprot id: D2GZB5
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9646:DRGX
gene id: 9646:DRGX
uniprot id: G1LV28
names: Subcellular Location Annotation
messages: Nucleus

9646:PSMA8
gene id: 9646:PSMA8
uniprot id: G1M6I4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9646:LOC100468607
gene id: 9646:LOC100468607
uniprot id: G1LEV6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9646:GPR137
gene id: 9646:GPR137
uniprot id: G1MI14
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9646:INTS11
gene id: 9646:INTS11
uniprot id: G1M5A3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

9646:S100PBP
gene id: 9646:S100PBP
uniprot id: G1LLP2
names: Subcellular Location Annotation
messages: Nucleus

9646:NDUFA12
gene id: 9646:NDUFA12
uniprot id: D2HBK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9646:SLCO1A2
gene id: 9646:SLCO1A2
uniprot id: G1L278
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:MRPL53
gene id: 9646:MRPL53
uniprot id: D2HH60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

9646:MAP2K6
gene id: 9646:MAP2K6
uniprot id: G1LLJ8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:CBLB
gene id: 9646:CBLB
uniprot id: A0A7N5P587
uniprot id: D2H3B0
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9646:TMX2
gene id: 9646:TMX2
uniprot id: G1M7S9
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9646:CYRIB
gene id: 9646:CYRIB
uniprot id: A0A7N5KPV4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9646:PEX16
gene id: 9646:PEX16
uniprot id: G1L1C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

9646:PMP22
gene id: 9646:PMP22
uniprot id: A0A7N5KNY5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

9646:ZBTB8OS
gene id: 9646:ZBTB8OS
uniprot id: A0A7N5KLM4
uniprot id: D2HI52
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

9646:C3H5orf63
gene id: 9646:C3H5orf63
uniprot id: A0A7N5JQH7
names: Similarity
messages: Belongs to the glutaredoxin family.

9646:LOC100469388
gene id: 9646:LOC100469388
uniprot id: D2I4W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:HDAC9
gene id: 9646:HDAC9
uniprot id: A0A7N5P1Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9646:LCTL
gene id: 9646:LCTL
uniprot id: D2GYU2
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9646:LPAR1
gene id: 9646:LPAR1
uniprot id: G1MI20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

9646:LBR
gene id: 9646:LBR
uniprot id: D2HYY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

9646:LTA4H
gene id: 9646:LTA4H
uniprot id: D2HBJ3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

9646:MRPS15
gene id: 9646:MRPS15
uniprot id: G1L3T6
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9646:DIS3L
gene id: 9646:DIS3L
uniprot id: A0A7N5K3I6
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9646:PRPS1
gene id: 9646:PRPS1
uniprot id: D2HJV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9646:NPRL2
gene id: 9646:NPRL2
uniprot id: D2HES3
names: Similarity
messages: Belongs to the NPR2 family.

9646:KCNS2
gene id: 9646:KCNS2
uniprot id: G1MN46
names: Subcellular Location Annotation
messages: Membrane

9646:MTTP
gene id: 9646:MTTP
uniprot id: G1L2K6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:NCOA2
gene id: 9646:NCOA2
uniprot id: G1LI96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9646:LOC100464456
gene id: 9646:LOC100464456
uniprot id: G1M220
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9646:TRIAP1
gene id: 9646:TRIAP1
uniprot id: G1M3T6
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

9646:SLCO5A1
gene id: 9646:SLCO5A1
uniprot id: D2H9L3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:MTMR6
gene id: 9646:MTMR6
uniprot id: G1M6K7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9646:MTFMT
gene id: 9646:MTFMT
uniprot id: G1L7P1
names: Similarity
messages: Belongs to the Fmt family.

9646:CAPZA3
gene id: 9646:CAPZA3
uniprot id: D2HI28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9646:P4HA1
gene id: 9646:P4HA1
uniprot id: A0A7N5JLM7
uniprot id: G1MF58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9646:CHMP2A
gene id: 9646:CHMP2A
uniprot id: G1LLY3
names: Similarity
messages: Belongs to the SNF7 family.

9646:SPINK4
gene id: 9646:SPINK4
uniprot id: D2HUA7
names: Subcellular Location Annotation
messages: Secreted

9646:LOC100466991
gene id: 9646:LOC100466991
uniprot id: A0A7N5KAP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9646:PHLDA3
gene id: 9646:PHLDA3
uniprot id: G1MNM5
names: Subcellular Location Annotation
messages: Cytoplasm

9646:NTAQ1
gene id: 9646:NTAQ1
uniprot id: A0A7N5KLL7
uniprot id: G1LXB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9646:PRKAR1B
gene id: 9646:PRKAR1B
uniprot id: D2I2Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9646:LOC100472558
gene id: 9646:LOC100472558
uniprot id: G1MKR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GRHL3
gene id: 9646:GRHL3
uniprot id: G1LTX3
names: Subcellular Location Annotation
messages: Nucleus

9646:SLC25A51
gene id: 9646:SLC25A51
uniprot id: D2H0I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:EFHC1
gene id: 9646:EFHC1
uniprot id: A0A7N5JCS1
names: Subcellular Location Annotation
messages: cilium axoneme

9646:TAAR5
gene id: 9646:TAAR5
uniprot id: D2HL29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9646:GLOD4
gene id: 9646:GLOD4
uniprot id: G1LNZ3
names: Similarity
messages: Belongs to the glyoxalase I family.

9646:ARMCX3
gene id: 9646:ARMCX3
uniprot id: D2I2N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9646:EBAG9
gene id: 9646:EBAG9
uniprot id: G1LHY8
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

9646:SLC35F6
gene id: 9646:SLC35F6
uniprot id: G1L5T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9646:NDUFAF3
gene id: 9646:NDUFAF3
uniprot id: D2HEW2
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9646:TMEM184A
gene id: 9646:TMEM184A
uniprot id: D2HNU1
names: Subcellular Location Annotation
messages: Membrane

9646:FHL5
gene id: 9646:FHL5
uniprot id: D2HXV6
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9646:LOC100474856
gene id: 9646:LOC100474856
uniprot id: A0A7N5K062
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9646:ZNF174
gene id: 9646:ZNF174
uniprot id: G1LVR7
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100468460
gene id: 9646:LOC100468460
uniprot id: D2I5M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9646:MED29
gene id: 9646:MED29
uniprot id: G1LPH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

9646:VAC14
gene id: 9646:VAC14
uniprot id: D2HFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9646:GSG1L2
gene id: 9646:GSG1L2
uniprot id: G1M092
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9646:LOC100483962
gene id: 9646:LOC100483962
uniprot id: A0A7N5JYF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9646:LOC100465141
gene id: 9646:LOC100465141
uniprot id: G1L9B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9646:PLPPR2
gene id: 9646:PLPPR2
uniprot id: G1LVU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9646:TSEN15
gene id: 9646:TSEN15
uniprot id: A0A7N5K8S0
names: Similarity
messages: Belongs to the SEN15 family.

9646:ACOX1
gene id: 9646:ACOX1
uniprot id: A0A7N5P608
uniprot id: G1LTX1
uniprot id: G1LTX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9646:NMBR
gene id: 9646:NMBR
uniprot id: D2GUS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:LOC100475019
gene id: 9646:LOC100475019
uniprot id: G1MMR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GAS6
gene id: 9646:GAS6
uniprot id: G1LCY3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:AKR1D1
gene id: 9646:AKR1D1
uniprot id: G1MI75
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9646:CA2
gene id: 9646:CA2
uniprot id: G1L761
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9646:EIF4EBP3
gene id: 9646:EIF4EBP3
uniprot id: A0A7N5JQS8
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9646:AP1S1
gene id: 9646:AP1S1
uniprot id: G1L7G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9646:PLP2
gene id: 9646:PLP2
uniprot id: D2H7M2
names: Subcellular Location Annotation
messages: Membrane

9646:SEMA4A
gene id: 9646:SEMA4A
uniprot id: G1M747
names: Similarity
messages: Belongs to the semaphorin family.

9646:PAF1
gene id: 9646:PAF1
uniprot id: G1LPL2
names: Similarity
messages: Belongs to the PAF1 family.

9646:RBP2
gene id: 9646:RBP2
uniprot id: D2I6R1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9646:MED23
gene id: 9646:MED23
uniprot id: A0A7N5JTE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

9646:GOSR1
gene id: 9646:GOSR1
uniprot id: G1LB09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9646:THNSL1
gene id: 9646:THNSL1
uniprot id: D2I7J7
names: Similarity
messages: Belongs to the threonine synthase family.

9646:TPRG1L
gene id: 9646:TPRG1L
uniprot id: D2HC11
names: Similarity
messages: Belongs to the TPRG1 family.

9646:CCNA1
gene id: 9646:CCNA1
uniprot id: A0A7N5KGS9
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9646:SLC25A17
gene id: 9646:SLC25A17
uniprot id: A0A7N5K0T6
uniprot id: G1M5K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:C4H2orf49
gene id: 9646:C4H2orf49
uniprot id: A0A7N5K3Z9
uniprot id: G1M3T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9646:PRKAR1A
gene id: 9646:PRKAR1A
uniprot id: D2HSY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9646:EFEMP1
gene id: 9646:EFEMP1
uniprot id: D2GY76
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:TEX261
gene id: 9646:TEX261
uniprot id: G1MBJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9646:HOXC4
gene id: 9646:HOXC4
uniprot id: D2HM48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9646:LAMP2
gene id: 9646:LAMP2
uniprot id: A0A7N5JZT9
uniprot id: G1L021
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9646:MSX2
gene id: 9646:MSX2
uniprot id: D2H5G1
names: Subcellular Location Annotation
messages: Nucleus

9646:PIGK
gene id: 9646:PIGK
uniprot id: G1LKX8
names: Similarity
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.

9646:GPR146
gene id: 9646:GPR146
uniprot id: G1MP48
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:ALKBH1
gene id: 9646:ALKBH1
uniprot id: D2HUS3
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

9646:TSR2
gene id: 9646:TSR2
uniprot id: A0A7N5JV56
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9646:KNG1
gene id: 9646:KNG1
uniprot id: A0A7N5JWY1
names: Subcellular Location Annotation
messages: extracellular space

9646:PPP5C
gene id: 9646:PPP5C
uniprot id: D2HL56
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

9646:MTMR10
gene id: 9646:MTMR10
uniprot id: G1MAA1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9646:MRPS24
gene id: 9646:MRPS24
uniprot id: D2HNM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

9646:CDR2L
gene id: 9646:CDR2L
uniprot id: A0A7N5K7G5
names: Similarity
messages: Belongs to the CDR2 family.

9646:GABRA6
gene id: 9646:GABRA6
uniprot id: D2GUJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:DDX28
gene id: 9646:DDX28
uniprot id: G1MM92
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9646:CCSER1
gene id: 9646:CCSER1
uniprot id: G1M968
names: Similarity
messages: Belongs to the CCSER family.

9646:LOC100465480
gene id: 9646:LOC100465480
uniprot id: A0A7N5J826
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9646:SFMBT1
gene id: 9646:SFMBT1
uniprot id: G1LN74
names: Subcellular Location Annotation
messages: Nucleus

9646:TAFA2
gene id: 9646:TAFA2
uniprot id: A0A7N5JQF8
names: Similarity
messages: Belongs to the TAFA family.

9646:AMPD2
gene id: 9646:AMPD2
uniprot id: A0A7N5KLQ8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9646:PPM1A
gene id: 9646:PPM1A
uniprot id: A0A7N5JUQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9646:MPZ
gene id: 9646:MPZ
uniprot id: G1MA37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myelin P0 protein family.
messages: Cell membrane
messages: Homodimer and homotetramer.
messages: Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
messages: Membrane

9646:INO80C
gene id: 9646:INO80C
uniprot id: G1L0P4
names: Subcellular Location Annotation
messages: Nucleus

9646:MFRP
gene id: 9646:MFRP
uniprot id: D2GYA3
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:GALNT13
gene id: 9646:GALNT13
uniprot id: G1LGB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9646:LOC100468691
gene id: 9646:LOC100468691
uniprot id: G1M9E3
names: Similarity
messages: Belongs to the serpin family.

9646:LYG1
gene id: 9646:LYG1
uniprot id: G1M3X2
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9646:LOC100471205
gene id: 9646:LOC100471205
uniprot id: D2HLN1
names: Similarity
messages: Belongs to the intermediate filament family.

9646:PTPN22
gene id: 9646:PTPN22
uniprot id: G1L9D3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.

9646:RPL30
gene id: 9646:RPL30
uniprot id: D3YBZ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9646:TENT5C
gene id: 9646:TENT5C
uniprot id: D2HQ27
names: Similarity
messages: Belongs to the TENT family.

9646:MTRF1
gene id: 9646:MTRF1
uniprot id: D2H2S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9646:POLR2C
gene id: 9646:POLR2C
uniprot id: D2GTX3
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9646:LDLRAD4
gene id: 9646:LDLRAD4
uniprot id: A0A7N5KQH9
uniprot id: G1MH96
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:STXBP5
gene id: 9646:STXBP5
uniprot id: A0A7N5JD04
uniprot id: A0A7N5JSX7
uniprot id: G1MCW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9646:NEU2
gene id: 9646:NEU2
uniprot id: G1MD87
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9646:ZMYND10
gene id: 9646:ZMYND10
uniprot id: D2HES4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Dynein axonemal particle
messages: centriolar satellite

9646:MGAT5B
gene id: 9646:MGAT5B
uniprot id: A0A7N5P134
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:PDZK1IP1
gene id: 9646:PDZK1IP1
uniprot id: A0A7N5K0K0
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100470998
gene id: 9646:LOC100470998
uniprot id: G1MDS2
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9646:MLF1
gene id: 9646:MLF1
uniprot id: A0A7N5JY32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9646:TMEM39A
gene id: 9646:TMEM39A
uniprot id: G1LL27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9646:SLC1A3
gene id: 9646:SLC1A3
uniprot id: D2HLY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9646:GABRA5
gene id: 9646:GABRA5
uniprot id: D2HI26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:MYH9
gene id: 9646:MYH9
uniprot id: D2GZG2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9646:ISL1
gene id: 9646:ISL1
uniprot id: G1LH63
names: Subcellular Location Annotation
messages: Nucleus

9646:SS18L2
gene id: 9646:SS18L2
uniprot id: D2HSV4
names: Similarity
messages: Belongs to the SS18 family.

9646:UBE2E2
gene id: 9646:UBE2E2
uniprot id: A0A7N5K1K9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9646:NPPB
gene id: 9646:NPPB
uniprot id: A0A7N5JXD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.
messages: Secreted

9646:COMP
gene id: 9646:COMP
uniprot id: D2GV41
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:LOC100469323
gene id: 9646:LOC100469323
uniprot id: D2H861
names: Similarity
messages: Belongs to the GAGE family.

9646:FAM3B
gene id: 9646:FAM3B
uniprot id: A0A7N5KR41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9646:FOXL1
gene id: 9646:FOXL1
uniprot id: D2GWM9
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100480547
gene id: 9646:LOC100480547
uniprot id: D2I7M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TGM7
gene id: 9646:TGM7
uniprot id: G1MAE9
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9646:RASGRP4
gene id: 9646:RASGRP4
uniprot id: G1LUU4
names: Similarity
messages: Belongs to the RASGRP family.

9646:GBF1
gene id: 9646:GBF1
uniprot id: D2GXW0
names: Subcellular Location Annotation
messages: Golgi apparatus

9646:PIAS2
gene id: 9646:PIAS2
uniprot id: A0A7N5KI91
names: Similarity
messages: Belongs to the PIAS family.

9646:C16H11orf58
gene id: 9646:C16H11orf58
uniprot id: G1L7X6
names: Similarity
messages: Belongs to the SMAP family.

9646:IFI44L
gene id: 9646:IFI44L
uniprot id: D2HHV1
names: Similarity
messages: Belongs to the IFI44 family.

9646:DDR1
gene id: 9646:DDR1
uniprot id: A0A7N5KTC7
uniprot id: A0A7N5P9Y9
uniprot id: G1M3B9
names: Subcellular Location Annotation
messages: Membrane

9646:PPM1L
gene id: 9646:PPM1L
uniprot id: G1MGQ6
names: Similarity
messages: Belongs to the PP2C family.

9646:MYOZ3
gene id: 9646:MYOZ3
uniprot id: G1LD46
names: Similarity
messages: Belongs to the myozenin family.

9646:TSPAN13
gene id: 9646:TSPAN13
uniprot id: G1LVH0
names: Subcellular Location Annotation
messages: Membrane

9646:FAM32A
gene id: 9646:FAM32A
uniprot id: A0A7N5KC65
names: Similarity
messages: Belongs to the FAM32 family.

9646:C17H9orf64
gene id: 9646:C17H9orf64
uniprot id: D2H0P0
names: Function
names: Similarity
messages: Belongs to the QNG1 protein family.
messages: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.

9646:RPS6
gene id: 9646:RPS6
uniprot id: F2X207
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

9646:BEX4
gene id: 9646:BEX4
uniprot id: D2I6F6
names: Similarity
messages: Belongs to the BEX family.

9646:ATP6V1E2
gene id: 9646:ATP6V1E2
uniprot id: D2GUA6
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9646:SLC25A20
gene id: 9646:SLC25A20
uniprot id: G1L0V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:GNB2
gene id: 9646:GNB2
uniprot id: D2HX06
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9646:CYFIP2
gene id: 9646:CYFIP2
uniprot id: A0A7N5K9J0
uniprot id: G1LI36
names: Similarity
messages: Belongs to the CYFIP family.

9646:ETFRF1
gene id: 9646:ETFRF1
uniprot id: A0A7N5JE42
names: Similarity
messages: Belongs to the complex I LYR family.

9646:HECTD1
gene id: 9646:HECTD1
uniprot id: A0A7N5KQT6
uniprot id: D2H9M5
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

9646:LPL
gene id: 9646:LPL
uniprot id: G1L2A1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9646:PKIB
gene id: 9646:PKIB
uniprot id: A0A7N5KFI2
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9646:MRPS26
gene id: 9646:MRPS26
uniprot id: D2HAC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9646:THOC6
gene id: 9646:THOC6
uniprot id: G1LFY6
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9646:FGFR1OP2
gene id: 9646:FGFR1OP2
uniprot id: A0A7N5JX31
uniprot id: D2H5Z7
names: Similarity
messages: Belongs to the SIKE family.

9646:USP45
gene id: 9646:USP45
uniprot id: G1LQW2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9646:UCHL3
gene id: 9646:UCHL3
uniprot id: A0A7N5KM99
uniprot id: G1LY51
names: Similarity
messages: Belongs to the peptidase C12 family.

9646:SH2B1
gene id: 9646:SH2B1
uniprot id: A0A7N5KRY4
names: Similarity
messages: Belongs to the SH2B adapter family.

9646:LOC100477680
gene id: 9646:LOC100477680
uniprot id: G1L058
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation.
messages: Membrane

9646:XIRP1
gene id: 9646:XIRP1
uniprot id: D2I4K2
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9646:LOC100483773
gene id: 9646:LOC100483773
uniprot id: D2HNC5
names: Subcellular Location Annotation
messages: Membrane

9646:GPAM
gene id: 9646:GPAM
uniprot id: G1MAU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

9646:BSCL2
gene id: 9646:BSCL2
uniprot id: G1LIS1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:CTSW
gene id: 9646:CTSW
uniprot id: A0A7N5KF48
names: Similarity
messages: Belongs to the peptidase C1 family.

9646:NDUFS3
gene id: 9646:NDUFS3
uniprot id: G1LM91
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

9646:ARG2
gene id: 9646:ARG2
uniprot id: D2HRG3
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9646:XRN2
gene id: 9646:XRN2
uniprot id: G1M1T0
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9646:CMTM5
gene id: 9646:CMTM5
uniprot id: A0A7N5P7S2
names: Subcellular Location Annotation
messages: Membrane

9646:ZC3HAV1
gene id: 9646:ZC3HAV1
uniprot id: A0A7N5K4N0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9646:HMGN4
gene id: 9646:HMGN4
uniprot id: D2I670
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9646:DRAM2
gene id: 9646:DRAM2
uniprot id: D2HXF6
names: Subcellular Location Annotation
messages: Membrane

9646:ACVR1C
gene id: 9646:ACVR1C
uniprot id: G1M6Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9646:GOT1
gene id: 9646:GOT1
uniprot id: D2I671
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9646:SLC34A3
gene id: 9646:SLC34A3
uniprot id: G1MDA4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9646:LOC109490817
gene id: 9646:LOC109490817
uniprot id: D2HWJ2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:PDSS2
gene id: 9646:PDSS2
uniprot id: G1LN41
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9646:LOC100478626
gene id: 9646:LOC100478626
uniprot id: D2I4D4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:INSM2
gene id: 9646:INSM2
uniprot id: D2HKI4
names: Subcellular Location Annotation
messages: Nucleus

9646:TSR1
gene id: 9646:TSR1
uniprot id: D2H8B1
names: Subcellular Location Annotation
messages: nucleolus

9646:MTO1
gene id: 9646:MTO1
uniprot id: G1LMJ9
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

9646:ATP5MD
gene id: 9646:ATP5MD
uniprot id: D2GXX9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion membrane

9646:MTX3
gene id: 9646:MTX3
uniprot id: A0A7N5JER4
uniprot id: G1MAX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9646:NR5A1
gene id: 9646:NR5A1
uniprot id: D2HDG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9646:VPS33A
gene id: 9646:VPS33A
uniprot id: D2GVX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9646:PATL2
gene id: 9646:PATL2
uniprot id: A0A7N5KRF4
names: Similarity
messages: Belongs to the PAT1 family.

9646:FGF13
gene id: 9646:FGF13
uniprot id: A0A7N5P3Y9
uniprot id: G1MCK0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9646:E2F7
gene id: 9646:E2F7
uniprot id: D2I4G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9646:APOOL
gene id: 9646:APOOL
uniprot id: A0A7N5JKU1
uniprot id: A0A7N5KBH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9646:LOC100482789
gene id: 9646:LOC100482789
uniprot id: D2HWJ2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:GAREM1
gene id: 9646:GAREM1
uniprot id: D2HQL4
names: Similarity
messages: Belongs to the GAREM family.

9646:METAP2
gene id: 9646:METAP2
uniprot id: D2HBJ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9646:LOC100474000
gene id: 9646:LOC100474000
uniprot id: G1MNB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC100469047
gene id: 9646:LOC100469047
uniprot id: A0A7N5KL52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9646:LYRM7
gene id: 9646:LYRM7
uniprot id: G1MHE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9646:SLC25A40
gene id: 9646:SLC25A40
uniprot id: G1L2Y7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9646:NCAPG
gene id: 9646:NCAPG
uniprot id: D2I3G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9646:LOC100465110
gene id: 9646:LOC100465110
uniprot id: D2HZU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:ACTL7B
gene id: 9646:ACTL7B
uniprot id: D2H478
names: Similarity
messages: Belongs to the actin family.

9646:ZNF532
gene id: 9646:ZNF532
uniprot id: A0A7N5JA96
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9646:ENKD1
gene id: 9646:ENKD1
uniprot id: G1MGK6
names: Subcellular Location Annotation
messages: cilium axoneme

9646:LOC100480861
gene id: 9646:LOC100480861
uniprot id: D2HMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9646:CDK7
gene id: 9646:CDK7
uniprot id: G1L901
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9646:RHBG
gene id: 9646:RHBG
uniprot id: A0A7N5KNF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9646:PGK1
gene id: 9646:PGK1
uniprot id: G1MGY6
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9646:NDEL1
gene id: 9646:NDEL1
uniprot id: G1L6P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9646:SNX2
gene id: 9646:SNX2
uniprot id: A0A7N5P5U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9646:TGS1
gene id: 9646:TGS1
uniprot id: G1L4R9
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9646:NAA35
gene id: 9646:NAA35
uniprot id: A0A7N5JJL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9646:AMBP
gene id: 9646:AMBP
uniprot id: G1M2K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: extracellular matrix

9646:FGF18
gene id: 9646:FGF18
uniprot id: A0A7N5JGX8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9646:ETV1
gene id: 9646:ETV1
uniprot id: D2HPJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:MRPS12
gene id: 9646:MRPS12
uniprot id: G1LQ39
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

9646:CSNK1G1
gene id: 9646:CSNK1G1
uniprot id: G1L735
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9646:NFE2L2
gene id: 9646:NFE2L2
uniprot id: G1LZQ0
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9646:SLC7A9
gene id: 9646:SLC7A9
uniprot id: G1MAI1
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100479124
gene id: 9646:LOC100479124
uniprot id: D2I0D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:STARD3NL
gene id: 9646:STARD3NL
uniprot id: G1M6S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Membrane

9646:DEFB127
gene id: 9646:DEFB127
uniprot id: G1LXR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9646:TEFM
gene id: 9646:TEFM
uniprot id: G1LG24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEFM family.
messages: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
messages: mitochondrion nucleoid

9646:CENPC
gene id: 9646:CENPC
uniprot id: G1L9R7
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

9646:GPHB5
gene id: 9646:GPHB5
uniprot id: D2GYJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9646:LOC100472982
gene id: 9646:LOC100472982
uniprot id: D2I6U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:IL5RA
gene id: 9646:IL5RA
uniprot id: G1M7H0
names: Subcellular Location Annotation
messages: Membrane

9646:VCAM1
gene id: 9646:VCAM1
uniprot id: G1LSS1
names: Subcellular Location Annotation
messages: Cell membrane

9646:FEN1
gene id: 9646:FEN1
uniprot id: D2HUF5
names: Function
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

9646:DCLRE1C
gene id: 9646:DCLRE1C
uniprot id: D2I3V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9646:PEX5L
gene id: 9646:PEX5L
uniprot id: A0A7N5JKF0
uniprot id: A0A7N5KI43
uniprot id: A0A7N5KIT8
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9646:PTPRG
gene id: 9646:PTPRG
uniprot id: G1MA58
uniprot id: G1MA60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9646:TMEM205
gene id: 9646:TMEM205
uniprot id: D2HGW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9646:NDUFAF4
gene id: 9646:NDUFAF4
uniprot id: A0A7N5K2H8
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9646:CDC6
gene id: 9646:CDC6
uniprot id: D2HR21
names: Similarity
messages: Belongs to the CDC6/cdc18 family.

9646:POLR2I
gene id: 9646:POLR2I
uniprot id: D2HFU4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: nucleolus

9646:FAM124A
gene id: 9646:FAM124A
uniprot id: G1LZX6
names: Similarity
messages: Belongs to the FAM124 family.

9646:LOC100484909
gene id: 9646:LOC100484909
uniprot id: A0A7N5JVU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:BNIP3
gene id: 9646:BNIP3
uniprot id: G1LWI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9646:ACTR8
gene id: 9646:ACTR8
uniprot id: D2I1E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core (By similarity).
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity).
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity).

9646:PEX12
gene id: 9646:PEX12
uniprot id: D2HML4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9646:LOC100478510
gene id: 9646:LOC100478510
uniprot id: D2HV38
names: Similarity
messages: Belongs to the FAH family.

9646:CDC37L1
gene id: 9646:CDC37L1
uniprot id: D2HPJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9646:HNRNPC
gene id: 9646:HNRNPC
uniprot id: D2HYC2
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9646:CHRNG
gene id: 9646:CHRNG
uniprot id: G1MDK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:MBTPS2
gene id: 9646:MBTPS2
uniprot id: A0A7N5K4E3
names: Similarity
messages: Belongs to the peptidase M50A family.

9646:ACADL
gene id: 9646:ACADL
uniprot id: G1LEE6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

9646:STAC
gene id: 9646:STAC
uniprot id: D2GZR9
names: Subcellular Location Annotation
messages: sarcolemma

9646:ARL4C
gene id: 9646:ARL4C
uniprot id: D2H830
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9646:RBBP7
gene id: 9646:RBBP7
uniprot id: A0A7N5JLH6
names: Subcellular Location Annotation
messages: Nucleus

9646:UBE2S
gene id: 9646:UBE2S
uniprot id: G1LAQ6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9646:FTSJ1
gene id: 9646:FTSJ1
uniprot id: G1M262
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

9646:MGAT2
gene id: 9646:MGAT2
uniprot id: D2HIE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

9646:BCCIP
gene id: 9646:BCCIP
uniprot id: A0A7N5JPH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

9646:BCORL1
gene id: 9646:BCORL1
uniprot id: A0A7N5K2Y5
uniprot id: G1M8Y0
names: Similarity
messages: Belongs to the BCOR family.

9646:RPL9
gene id: 9646:RPL9
uniprot id: D9ZLV7
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

9646:AGTR1
gene id: 9646:AGTR1
uniprot id: D2HWD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

9646:TMPRSS11D
gene id: 9646:TMPRSS11D
uniprot id: G1L9Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9646:ISY1
gene id: 9646:ISY1
uniprot id: G1MA22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9646:SF3A2
gene id: 9646:SF3A2
uniprot id: D2HTL8
names: Similarity
messages: Belongs to the SF3A2 family.

9646:RNFT2
gene id: 9646:RNFT2
uniprot id: G1M1C9
names: Subcellular Location Annotation
messages: Membrane

9646:UBE2H
gene id: 9646:UBE2H
uniprot id: A0A7N5KHJ1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9646:LOC100483670
gene id: 9646:LOC100483670
uniprot id: G1LTA5
names: Similarity
messages: Belongs to the CBP3 family.

9646:MED19
gene id: 9646:MED19
uniprot id: G1M7Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9646:GABRA2
gene id: 9646:GABRA2
uniprot id: G1L9Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9646:LOC100464289
gene id: 9646:LOC100464289
uniprot id: G1L379
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9646:CCDC47
gene id: 9646:CCDC47
uniprot id: G1L946
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC47 family.
messages: Rough endoplasmic reticulum membrane

9646:EIF4A2
gene id: 9646:EIF4A2
uniprot id: G1L2C1
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9646:EHD2
gene id: 9646:EHD2
uniprot id: D2H814
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9646:GLI3
gene id: 9646:GLI3
uniprot id: D2GYG0
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9646:CMBL
gene id: 9646:CMBL
uniprot id: D2H9W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9646:TCL1A
gene id: 9646:TCL1A
uniprot id: G1LIZ1
names: Similarity
messages: Belongs to the TCL1 family.

9646:A4GALT
gene id: 9646:A4GALT
uniprot id: D2HVM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9646:DOP1B
gene id: 9646:DOP1B
uniprot id: D2H5T8
names: Similarity
messages: Belongs to the dopey family.

9646:SCG2
gene id: 9646:SCG2
uniprot id: D2H9R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Interacts with Secretogranin III/SCG3.
messages: Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
messages: Secreted

9646:ANAPC1
gene id: 9646:ANAPC1
uniprot id: D2HPH2
names: Similarity
messages: Belongs to the APC1 family.

9646:MSMP
gene id: 9646:MSMP
uniprot id: D2HAL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9646:CRX
gene id: 9646:CRX
uniprot id: D2H811
names: Subcellular Location Annotation
messages: Nucleus

9646:NSUN3
gene id: 9646:NSUN3
uniprot id: G1L6T2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9646:LOC100483551
gene id: 9646:LOC100483551
uniprot id: D2I489
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GPR15
gene id: 9646:GPR15
uniprot id: D2HSL3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:ROCK1
gene id: 9646:ROCK1
uniprot id: G1LJU8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

9646:UNC5CL
gene id: 9646:UNC5CL
uniprot id: D2I3I3
names: Similarity
messages: Belongs to the unc-5 family.

9646:ZNF330
gene id: 9646:ZNF330
uniprot id: D2HWA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: centromere
messages: nucleolus

9646:EFTUD2
gene id: 9646:EFTUD2
uniprot id: G1MJ97
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100479852
gene id: 9646:LOC100479852
uniprot id: G1MLP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9646:SKA3
gene id: 9646:SKA3
uniprot id: A0A7N5KHW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

9646:SLC22A18
gene id: 9646:SLC22A18
uniprot id: G1L689
names: Subcellular Location Annotation
messages: Membrane

9646:MC5R
gene id: 9646:MC5R
uniprot id: G1MLW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

9646:PDE1B
gene id: 9646:PDE1B
uniprot id: A0A7N5JNG4
uniprot id: D2HM59
uniprot id: G1L2M9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9646:MEF2C
gene id: 9646:MEF2C
uniprot id: A0A7N5KD46
uniprot id: G1M3T0
names: Subcellular Location Annotation
messages: Nucleus

9646:SGMS1
gene id: 9646:SGMS1
uniprot id: G1L163
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9646:ZSCAN30
gene id: 9646:ZSCAN30
uniprot id: G1L0Q4
names: Subcellular Location Annotation
messages: Nucleus

9646:TRAK2
gene id: 9646:TRAK2
uniprot id: D2H2Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9646:SLC6A7
gene id: 9646:SLC6A7
uniprot id: G1LE93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9646:MYD88
gene id: 9646:MYD88
uniprot id: D2GZQ7
names: Subcellular Location Annotation
messages: Cytoplasm

9646:NMI
gene id: 9646:NMI
uniprot id: G1M320
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9646:HSD17B11
gene id: 9646:HSD17B11
uniprot id: G1L975
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:CCDC130
gene id: 9646:CCDC130
uniprot id: G1M2N3
names: Similarity
messages: Belongs to the CWC16 family.

9646:GALNT7
gene id: 9646:GALNT7
uniprot id: D2GUW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9646:KDM5A
gene id: 9646:KDM5A
uniprot id: G1LCY8
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

9646:ARL5A
gene id: 9646:ARL5A
uniprot id: G1LQ72
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9646:MLH3
gene id: 9646:MLH3
uniprot id: D2GZX5
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9646:ADORA1
gene id: 9646:ADORA1
uniprot id: D2HSE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9646:ANAPC10
gene id: 9646:ANAPC10
uniprot id: D2H3Q0
names: Similarity
messages: Belongs to the APC10 family.

9646:LOC100475093
gene id: 9646:LOC100475093
uniprot id: A0A7N5KED1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:HOXD13
gene id: 9646:HOXD13
uniprot id: D2I1G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9646:MRPL24
gene id: 9646:MRPL24
uniprot id: G1M8U4
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9646:DHH
gene id: 9646:DHH
uniprot id: D2HWS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9646:JOSD2
gene id: 9646:JOSD2
uniprot id: A0A7N5P4F2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:COQ7
gene id: 9646:COQ7
uniprot id: G1LWZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9646:LITAFD
gene id: 9646:LITAFD
uniprot id: D2HCQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9646:SOAT2
gene id: 9646:SOAT2
uniprot id: G1M0E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:NSF
gene id: 9646:NSF
uniprot id: G1LC54
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

9646:CALB2
gene id: 9646:CALB2
uniprot id: D2HFV9
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9646:HMBS
gene id: 9646:HMBS
uniprot id: G1KZJ1
names: Similarity
messages: Belongs to the HMBS family.

9646:RGS4
gene id: 9646:RGS4
uniprot id: A0A7N5JXW7
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9646:ZAR1L
gene id: 9646:ZAR1L
uniprot id: A0A7N5JEW6
names: Similarity
names: Subunit
messages: Belongs to the ZAR1 family.
messages: Interacts with YBX2.

9646:OSBPL3
gene id: 9646:OSBPL3
uniprot id: A0A7N5JWU7
uniprot id: A0A7N5KNK7
uniprot id: G1LHM0
names: Similarity
messages: Belongs to the OSBP family.

9646:ARF3
gene id: 9646:ARF3
uniprot id: D2HWS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9646:HNRNPH2
gene id: 9646:HNRNPH2
uniprot id: D2I2N0
names: Subcellular Location Annotation
messages: nucleoplasm

9646:LOC100467027
gene id: 9646:LOC100467027
uniprot id: G1LGF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9646:TSSK6
gene id: 9646:TSSK6
uniprot id: G1MM19
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:LOC100464593
gene id: 9646:LOC100464593
uniprot id: G1LZR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9646:GALNT11
gene id: 9646:GALNT11
uniprot id: D2H1U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9646:KCNV1
gene id: 9646:KCNV1
uniprot id: A0A7N5KFZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9646:LOC100484465
gene id: 9646:LOC100484465
uniprot id: A0A7N5K4U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:PLPPR1
gene id: 9646:PLPPR1
uniprot id: G1L1E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9646:KCNK10
gene id: 9646:KCNK10
uniprot id: A0A7N5P8U6
uniprot id: G1L3G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9646:CPD
gene id: 9646:CPD
uniprot id: D2GU00
names: Similarity
messages: Belongs to the peptidase M14 family.

9646:DNM2
gene id: 9646:DNM2
uniprot id: A0A7N5KJC2
uniprot id: G1LX99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Cytoplasm

9646:PSME1
gene id: 9646:PSME1
uniprot id: G1MDG8
names: Similarity
messages: Belongs to the PA28 family.

9646:SFXN2
gene id: 9646:SFXN2
uniprot id: D2GXW8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9646:CTPS2
gene id: 9646:CTPS2
uniprot id: G1LV08
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9646:LOC100479104
gene id: 9646:LOC100479104
uniprot id: G1MML8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CAVIN4
gene id: 9646:CAVIN4
uniprot id: A0A7N5K393
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9646:LOC100468377
gene id: 9646:LOC100468377
uniprot id: D2HZC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GPX5
gene id: 9646:GPX5
uniprot id: A0A7N5P2N0
uniprot id: G1M5L9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9646:POP5
gene id: 9646:POP5
uniprot id: D2I158
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

9646:CDC14B
gene id: 9646:CDC14B
uniprot id: A0A7N5KFP6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9646:RPL5
gene id: 9646:RPL5
uniprot id: D9ZLV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9646:PAQR7
gene id: 9646:PAQR7
uniprot id: G1MPF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9646:BVES
gene id: 9646:BVES
uniprot id: D2H5S1
names: Similarity
messages: Belongs to the popeye family.

9646:C16H11orf49
gene id: 9646:C16H11orf49
uniprot id: A0A7N5JEZ1
uniprot id: G1LKS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: cytoskeleton

9646:KRT35
gene id: 9646:KRT35
uniprot id: D2HIQ9
names: Similarity
messages: Belongs to the intermediate filament family.

9646:LACTB2
gene id: 9646:LACTB2
uniprot id: G1LIE5
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

9646:UQCRQ
gene id: 9646:UQCRQ
uniprot id: D2GVI2
uniprot id: Q2L897
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with UQCC6 (By similarity).
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9646:ANO6
gene id: 9646:ANO6
uniprot id: A0A7N5KRZ0
uniprot id: G1MBD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9646:NRP2
gene id: 9646:NRP2
uniprot id: A0A7N5JBX0
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:CDKN1B
gene id: 9646:CDKN1B
uniprot id: G1LW64
names: Similarity
messages: Belongs to the CDI family.

9646:TARS1
gene id: 9646:TARS1
uniprot id: G1L9U5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9646:ORC2
gene id: 9646:ORC2
uniprot id: G1LHB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

9646:GPR155
gene id: 9646:GPR155
uniprot id: G1M0P4
names: Subcellular Location Annotation
messages: Membrane

9646:DYNC2LI1
gene id: 9646:DYNC2LI1
uniprot id: G1LGN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

9646:KRT222
gene id: 9646:KRT222
uniprot id: D2HR27
names: Similarity
messages: Belongs to the intermediate filament family.

9646:SEMA5B
gene id: 9646:SEMA5B
uniprot id: A0A7N5KF69
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:LOC100466939
gene id: 9646:LOC100466939
uniprot id: D2HZU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:MSN
gene id: 9646:MSN
uniprot id: A0A7N5JF56
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9646:B3GNT8
gene id: 9646:B3GNT8
uniprot id: D2HMT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:PRND
gene id: 9646:PRND
uniprot id: D2HQS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9646:LOC100473055
gene id: 9646:LOC100473055
uniprot id: G1MJV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:HIRIP3
gene id: 9646:HIRIP3
uniprot id: D2HX43
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100467289
gene id: 9646:LOC100467289
uniprot id: G1MP84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:SAR1B
gene id: 9646:SAR1B
uniprot id: G1MHM6
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9646:CHST10
gene id: 9646:CHST10
uniprot id: G1MB03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:CLASP1
gene id: 9646:CLASP1
uniprot id: G1LF58
names: Subcellular Location Annotation
messages: kinetochore

9646:TMED1
gene id: 9646:TMED1
uniprot id: D2HGX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9646:GLE1
gene id: 9646:GLE1
uniprot id: G1MAN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

9646:PSMC2
gene id: 9646:PSMC2
uniprot id: G1M9S2
names: Similarity
messages: Belongs to the AAA ATPase family.

9646:IL6
gene id: 9646:IL6
uniprot id: H2DL91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.
messages: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
messages: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells.
messages: Secreted

9646:PNLIPRP3
gene id: 9646:PNLIPRP3
uniprot id: G1M5Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9646:GCNT1
gene id: 9646:GCNT1
uniprot id: D2HPX9
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9646:GLRX
gene id: 9646:GLRX
uniprot id: D2HYF9
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9646:TMEM225
gene id: 9646:TMEM225
uniprot id: G1M061
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100479287
gene id: 9646:LOC100479287
uniprot id: D2I475
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TECR
gene id: 9646:TECR
uniprot id: G1LY96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:TAF1
gene id: 9646:TAF1
uniprot id: A0A7N5KI20
uniprot id: D2I1M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF1 family.
messages: Nucleus

9646:IWS1
gene id: 9646:IWS1
uniprot id: A0A7N5KJZ2
names: Subcellular Location Annotation
messages: Nucleus

9646:TM9SF1
gene id: 9646:TM9SF1
uniprot id: D2HG51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9646:CPA4
gene id: 9646:CPA4
uniprot id: A0A7N5KHX7
uniprot id: G1LFX7
names: Similarity
messages: Belongs to the peptidase M14 family.

9646:STXBP3
gene id: 9646:STXBP3
uniprot id: G1LCM9
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9646:PEG3
gene id: 9646:PEG3
uniprot id: A0A7N5P0T1
names: Subcellular Location Annotation
messages: Nucleus

9646:TRMT6
gene id: 9646:TRMT6
uniprot id: D2HR95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM6/GCD10 family.
messages: Nucleus

9646:EMP2
gene id: 9646:EMP2
uniprot id: A0A7N5P9K1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

9646:TBXA2R
gene id: 9646:TBXA2R
uniprot id: G1LGK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:KCNJ4
gene id: 9646:KCNJ4
uniprot id: D2GZJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9646:KCNJ11
gene id: 9646:KCNJ11
uniprot id: D2HRL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9646:RHBDD1
gene id: 9646:RHBDD1
uniprot id: G1LC53
names: Subcellular Location Annotation
messages: Membrane

9646:MEIG1
gene id: 9646:MEIG1
uniprot id: D2HVH0
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9646:MED28
gene id: 9646:MED28
uniprot id: D2H3S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9646:LYZ
gene id: 9646:LYZ
uniprot id: G1LZC7
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9646:GHRHR
gene id: 9646:GHRHR
uniprot id: G1LJT4
names: Subcellular Location Annotation
messages: Membrane

9646:IGFBP5
gene id: 9646:IGFBP5
uniprot id: D2GXE6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:LMX1A
gene id: 9646:LMX1A
uniprot id: G1LJ50
names: Subcellular Location Annotation
messages: Nucleus

9646:SEMA6D
gene id: 9646:SEMA6D
uniprot id: A0A7N5K4L6
uniprot id: A0A7N5P8U1
uniprot id: G1L5L8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:KEG54 p13
gene id: 9646:KEG54_p13
uniprot id: A5JFJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 1 family.
messages: Membrane
messages: Mitochondrion inner membrane

9646:BECN1
gene id: 9646:BECN1
uniprot id: A0A7N5K7W5
uniprot id: A0A7N5KHM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9646:PTGS1
gene id: 9646:PTGS1
uniprot id: G1L1M8
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:PITX2
gene id: 9646:PITX2
uniprot id: A0A7N5JAK8
uniprot id: A0A7N5KBN9
uniprot id: D2H704
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9646:GDF15
gene id: 9646:GDF15
uniprot id: D2GV32
names: Similarity
messages: Belongs to the TGF-beta family.

9646:MCM7
gene id: 9646:MCM7
uniprot id: A0A7N5JDX4
uniprot id: G1LXH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9646:MCM3
gene id: 9646:MCM3
uniprot id: G1LPP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9646:TCTN2
gene id: 9646:TCTN2
uniprot id: D2GW03
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9646:ATAT1
gene id: 9646:ATAT1
uniprot id: A0A7N5JHA3
uniprot id: G1M3R3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

9646:TBX5
gene id: 9646:TBX5
uniprot id: D2HSK1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9646:LOC100476935
gene id: 9646:LOC100476935
uniprot id: D2I5X4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:PIGH
gene id: 9646:PIGH
uniprot id: D2HRG4
names: Similarity
messages: Belongs to the PIGH family.

9646:MED4
gene id: 9646:MED4
uniprot id: D2HB80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9646:PLCB3
gene id: 9646:PLCB3
uniprot id: G1MI45
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9646:LRRC8D
gene id: 9646:LRRC8D
uniprot id: D2HJK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9646:VIM
gene id: 9646:VIM
uniprot id: G1LVM5
names: Similarity
messages: Belongs to the intermediate filament family.

9646:TNFSF4
gene id: 9646:TNFSF4
uniprot id: A0A7N5P907
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9646:HSPA4
gene id: 9646:HSPA4
uniprot id: D2GVI6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9646:LHX4
gene id: 9646:LHX4
uniprot id: G1L861
names: Subcellular Location Annotation
messages: Nucleus

9646:S100A4
gene id: 9646:S100A4
uniprot id: D2HJR5
names: Similarity
messages: Belongs to the S-100 family.

9646:FERMT2
gene id: 9646:FERMT2
uniprot id: A0A7N5JDB0
names: Similarity
messages: Belongs to the kindlin family.

9646:ACSL1
gene id: 9646:ACSL1
uniprot id: D2GY67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9646:WARS1
gene id: 9646:WARS1
uniprot id: A0A7N5P2W1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9646:DNAJC5B
gene id: 9646:DNAJC5B
uniprot id: D2H417
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with the chaperone complex consisting of HSC70 and SGTA.
messages: Membrane
messages: Palmitoylated.

9646:DDX50
gene id: 9646:DDX50
uniprot id: G1MI27
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9646:DEFB124
gene id: 9646:DEFB124
uniprot id: G1M577
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9646:ATG2B
gene id: 9646:ATG2B
uniprot id: G1LB52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9646:ELAPOR1
gene id: 9646:ELAPOR1
uniprot id: G1LD17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9646:NR2C1
gene id: 9646:NR2C1
uniprot id: G1L677
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9646:STMN2
gene id: 9646:STMN2
uniprot id: A0A7N5JT04
names: Similarity
messages: Belongs to the stathmin family.

9646:MARVELD3
gene id: 9646:MARVELD3
uniprot id: A0A7N5P8R5
uniprot id: G1L6I4
names: Subcellular Location Annotation
messages: Membrane

9646:GPNMB
gene id: 9646:GPNMB
uniprot id: G1L9T3
names: Similarity
messages: Belongs to the PMEL/NMB family.

9646:SLC41A2
gene id: 9646:SLC41A2
uniprot id: D2H1T6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9646:LRRC8E
gene id: 9646:LRRC8E
uniprot id: D2HI92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9646:MMAA
gene id: 9646:MMAA
uniprot id: G1ME12
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

9646:CAMK4
gene id: 9646:CAMK4
uniprot id: G1M260
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:GLRA2
gene id: 9646:GLRA2
uniprot id: A0A7N5K5T1
uniprot id: G1LIA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9646:ATP10B
gene id: 9646:ATP10B
uniprot id: D2GUJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9646:KRT36
gene id: 9646:KRT36
uniprot id: D2HIR0
names: Similarity
messages: Belongs to the intermediate filament family.

9646:LOC100468886
gene id: 9646:LOC100468886
uniprot id: G1MN66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC100479707
gene id: 9646:LOC100479707
uniprot id: D2I7Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LALBA
gene id: 9646:LALBA
uniprot id: D2HWT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

9646:NAB1
gene id: 9646:NAB1
uniprot id: D2H878
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9646:TAF11
gene id: 9646:TAF11
uniprot id: D2GYX5
names: Similarity
messages: Belongs to the TAF11 family.

9646:PFKFB4
gene id: 9646:PFKFB4
uniprot id: G1L2T1
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9646:MCM8
gene id: 9646:MCM8
uniprot id: G1LVR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9646:DNTTIP1
gene id: 9646:DNTTIP1
uniprot id: D2HZ02
names: Subcellular Location Annotation
messages: Nucleus

9646:NDP
gene id: 9646:NDP
uniprot id: D2HZ86
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:SUPT6H
gene id: 9646:SUPT6H
uniprot id: G1LDR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9646:AP5M1
gene id: 9646:AP5M1
uniprot id: G1L6I9
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9646:DNAAF3
gene id: 9646:DNAAF3
uniprot id: G1L9X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF3 family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.

9646:KCNG1
gene id: 9646:KCNG1
uniprot id: D2GVM5
names: Subcellular Location Annotation
messages: Membrane

9646:FUNDC2
gene id: 9646:FUNDC2
uniprot id: A0A7N5K165
uniprot id: G1LZQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9646:NT5C3A
gene id: 9646:NT5C3A
uniprot id: A0A7N5JMU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9646:TPRA1
gene id: 9646:TPRA1
uniprot id: D2H7B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9646:NUTF2
gene id: 9646:NUTF2
uniprot id: D2H9F9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9646:ITPA
gene id: 9646:ITPA
uniprot id: G1LWZ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9646:ATP6V0C
gene id: 9646:ATP6V0C
uniprot id: D2HV78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9646:S100A2
gene id: 9646:S100A2
uniprot id: G1M0I8
names: Similarity
messages: Belongs to the S-100 family.

9646:AIF1
gene id: 9646:AIF1
uniprot id: G1LS81
names: Subcellular Location Annotation
messages: ruffle membrane

9646:INHA
gene id: 9646:INHA
uniprot id: G1MEP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9646:CCNT1
gene id: 9646:CCNT1
uniprot id: D2HWT3
names: Similarity
messages: Belongs to the cyclin family.

9646:TMEM41A
gene id: 9646:TMEM41A
uniprot id: D2H294
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9646:TM4SF20
gene id: 9646:TM4SF20
uniprot id: D2HCS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9646:RDH16
gene id: 9646:RDH16
uniprot id: D2H368
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:SULT1B1
gene id: 9646:SULT1B1
uniprot id: D2I2Q5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9646:ANKRD13C
gene id: 9646:ANKRD13C
uniprot id: D2I397
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100475430
gene id: 9646:LOC100475430
uniprot id: G1M060
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ACTR6
gene id: 9646:ACTR6
uniprot id: G1M9X8
names: Similarity
messages: Belongs to the actin family.

9646:RCL1
gene id: 9646:RCL1
uniprot id: D2HPJ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: nucleolus

9646:COQ9
gene id: 9646:COQ9
uniprot id: G1MF51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

9646:NFIL3
gene id: 9646:NFIL3
uniprot id: D2HB66
names: Similarity
messages: Belongs to the bZIP family. NFIL3 subfamily.

9646:EPO
gene id: 9646:EPO
uniprot id: G1M830
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Secreted

9646:PHB2
gene id: 9646:PHB2
uniprot id: G1M593
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9646:MMAB
gene id: 9646:MMAB
uniprot id: G1MDY1
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

9646:PRKCH
gene id: 9646:PRKCH
uniprot id: A0A7N5JK47
uniprot id: G1L8P0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9646:STAC2
gene id: 9646:STAC2
uniprot id: D2H530
names: Subcellular Location Annotation
messages: sarcolemma

9646:WDR83OS
gene id: 9646:WDR83OS
uniprot id: D2HG01
names: Similarity
messages: Belongs to the Asterix family.

9646:CHCHD6
gene id: 9646:CHCHD6
uniprot id: G1LIX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9646:SEPTIN6
gene id: 9646:SEPTIN6
uniprot id: A0A7N5JKF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9646:IRAK4
gene id: 9646:IRAK4
uniprot id: G1MG21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9646:SLC35D1
gene id: 9646:SLC35D1
uniprot id: D2HIA6
names: Subcellular Location Annotation
messages: Membrane

9646:EPHA5
gene id: 9646:EPHA5
uniprot id: A0A7N5K8C7
uniprot id: A0A7N5K9R3
uniprot id: G1LIF2
names: Subcellular Location Annotation
messages: Membrane

9646:FOXN3
gene id: 9646:FOXN3
uniprot id: G1L490
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
messages: Nucleus

9646:TUT1
gene id: 9646:TUT1
uniprot id: G1LJJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Nucleus speckle
messages: nucleolus

9646:TM4SF1
gene id: 9646:TM4SF1
uniprot id: G1LX24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9646:CEBPE
gene id: 9646:CEBPE
uniprot id: D2HTW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9646:ERCC4
gene id: 9646:ERCC4
uniprot id: G1LXW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

9646:LOC100484315
gene id: 9646:LOC100484315
uniprot id: G1MMT3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:RNF114
gene id: 9646:RNF114
uniprot id: G1M4D3
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
messages: Nucleus

9646:AGL
gene id: 9646:AGL
uniprot id: G1LR84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

9646:PPIF
gene id: 9646:PPIF
uniprot id: D2HJF4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9646:TIMM8A
gene id: 9646:TIMM8A
uniprot id: D2I0C2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9646:LOC100475268
gene id: 9646:LOC100475268
uniprot id: G1LET1
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9646:GSN
gene id: 9646:GSN
uniprot id: A0A7N5KBV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the villin/gelsolin family.
messages: Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts with the inactive form of EIF2AK2/PKR.
messages: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
messages: cytoskeleton

9646:DOK6
gene id: 9646:DOK6
uniprot id: G1MJ93
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9646:BLOC1S5
gene id: 9646:BLOC1S5
uniprot id: G1MG16
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

9646:LIF
gene id: 9646:LIF
uniprot id: A0A7N5JHJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

9646:CRHBP
gene id: 9646:CRHBP
uniprot id: A0A7N5JH78
uniprot id: D2HTE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

9646:CHMP5
gene id: 9646:CHMP5
uniprot id: G1LLT9
names: Similarity
messages: Belongs to the SNF7 family.

9646:GLRB
gene id: 9646:GLRB
uniprot id: G1M6Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9646:MAP2K3
gene id: 9646:MAP2K3
uniprot id: G1M0W7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:LOC100476812
gene id: 9646:LOC100476812
uniprot id: D2H9N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9646:PDX1
gene id: 9646:PDX1
uniprot id: D2HUX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9646:SCAMP4
gene id: 9646:SCAMP4
uniprot id: G1LF30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9646:ITPRIPL2
gene id: 9646:ITPRIPL2
uniprot id: D2HEL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9646:GAL3ST4
gene id: 9646:GAL3ST4
uniprot id: D2HX20
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9646:RALY
gene id: 9646:RALY
uniprot id: G1LR44
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9646:UHRF2
gene id: 9646:UHRF2
uniprot id: D2I1M3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

9646:SNX17
gene id: 9646:SNX17
uniprot id: G1L3Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9646:SNX32
gene id: 9646:SNX32
uniprot id: G1MG32
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9646:SNRPB
gene id: 9646:SNRPB
uniprot id: G1LXZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9646:CPVL
gene id: 9646:CPVL
uniprot id: D2GVB0
names: Similarity
messages: Belongs to the peptidase S10 family.

9646:LOC100469977
gene id: 9646:LOC100469977
uniprot id: D2I6S9
names: Subcellular Location Annotation
messages: Nucleus

9646:STK4
gene id: 9646:STK4
uniprot id: A0A7N5JI95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9646:ATP5MC1
gene id: 9646:ATP5MC1
uniprot id: D3JYS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9646:AP3B1
gene id: 9646:AP3B1
uniprot id: D2HE54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9646:TVP23B
gene id: 9646:TVP23B
uniprot id: G1LG44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9646:GFAP
gene id: 9646:GFAP
uniprot id: G1MJA2
names: Similarity
messages: Belongs to the intermediate filament family.

9646:LOC100471319
gene id: 9646:LOC100471319
uniprot id: D2HZU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:HSPA5
gene id: 9646:HSPA5
uniprot id: D2H3W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cell surface
messages: Endoplasmic reticulum lumen
messages: Melanosome

9646:NFS1
gene id: 9646:NFS1
uniprot id: A0A7N5K5N5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9646:RNF145
gene id: 9646:RNF145
uniprot id: A0A7N5KMS5
names: Subcellular Location Annotation
messages: Membrane

9646:FIP1L1
gene id: 9646:FIP1L1
uniprot id: A0A7N5JWW6
uniprot id: G1LN99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

9646:EXOC5
gene id: 9646:EXOC5
uniprot id: G1L6H6
names: Similarity
messages: Belongs to the SEC10 family.

9646:LOC100464279
gene id: 9646:LOC100464279
uniprot id: G1L6J1
names: Similarity
messages: Belongs to the MHC class II family.

9646:SELE
gene id: 9646:SELE
uniprot id: G1LXT1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:DDX56
gene id: 9646:DDX56
uniprot id: G1MH81
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9646:LOC100465782
gene id: 9646:LOC100465782
uniprot id: G1MNU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:RAD50
gene id: 9646:RAD50
uniprot id: G1MH82
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9646:CDIPT
gene id: 9646:CDIPT
uniprot id: D2HX36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9646:SLC13A3
gene id: 9646:SLC13A3
uniprot id: G1KZG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9646:COQ10B
gene id: 9646:COQ10B
uniprot id: G1M5C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9646:TMEM170B
gene id: 9646:TMEM170B
uniprot id: D2H2W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9646:PDHX
gene id: 9646:PDHX
uniprot id: D2HF00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9646:METTL14
gene id: 9646:METTL14
uniprot id: A0A7N5KLA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MT-A70-like family.
messages: Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.
messages: Nucleus
messages: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells.

9646:PIH1D2
gene id: 9646:PIH1D2
uniprot id: D2HG82
names: Similarity
messages: Belongs to the PIH1 family.

9646:C12H19orf54
gene id: 9646:C12H19orf54
uniprot id: D2HMV0
names: Similarity
messages: Belongs to the ACTMAP family.

9646:PELO
gene id: 9646:PELO
uniprot id: D2HHD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.
messages: Cytoplasm

9646:DGKE
gene id: 9646:DGKE
uniprot id: G1L7T6
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9646:ELSPBP1
gene id: 9646:ELSPBP1
uniprot id: G1M9H3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:TRUB2
gene id: 9646:TRUB2
uniprot id: A0A7N5JY12
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9646:CLCN6
gene id: 9646:CLCN6
uniprot id: G1LTG6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:TIMM22
gene id: 9646:TIMM22
uniprot id: G1LAL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9646:NME5
gene id: 9646:NME5
uniprot id: D2HK89
names: Similarity
messages: Belongs to the NDK family.

9646:SERPINB9
gene id: 9646:SERPINB9
uniprot id: D2I4F0
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9646:LOC100480908
gene id: 9646:LOC100480908
uniprot id: G1L7T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9646:SLC24A3
gene id: 9646:SLC24A3
uniprot id: G1L049
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9646:GCLC
gene id: 9646:GCLC
uniprot id: D2HKW5
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

9646:TPRKB
gene id: 9646:TPRKB
uniprot id: G1MGB1
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9646:FOXS1
gene id: 9646:FOXS1
uniprot id: D2H912
names: Subcellular Location Annotation
messages: Nucleus

9646:RARG
gene id: 9646:RARG
uniprot id: G1M0X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9646:TAF5L
gene id: 9646:TAF5L
uniprot id: D2HHC8
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9646:PCSK5
gene id: 9646:PCSK5
uniprot id: A0A7N5J982
names: Similarity
messages: Belongs to the peptidase S8 family.

9646:STT3A
gene id: 9646:STT3A
uniprot id: G1L2J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9646:PPP2R5C
gene id: 9646:PPP2R5C
uniprot id: A0A7N5KN42
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9646:ABCA12
gene id: 9646:ABCA12
uniprot id: G1LAR5
names: Subcellular Location Annotation
messages: Membrane

9646:DCLRE1B
gene id: 9646:DCLRE1B
uniprot id: G1L970
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9646:LOC100475000
gene id: 9646:LOC100475000
uniprot id: G1M427
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:HIKESHI
gene id: 9646:HIKESHI
uniprot id: G1LQD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9646:KIF22
gene id: 9646:KIF22
uniprot id: G1M8H7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9646:OST4
gene id: 9646:OST4
uniprot id: D2GXM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:JUP
gene id: 9646:JUP
uniprot id: D2HIR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9646:C4BPB
gene id: 9646:C4BPB
uniprot id: G1L9X7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:LOC100476547
gene id: 9646:LOC100476547
uniprot id: G1LCG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TFDP2
gene id: 9646:TFDP2
uniprot id: A0A7N5K2J9
uniprot id: G1M1D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9646:OSBPL1A
gene id: 9646:OSBPL1A
uniprot id: D2GUU7
names: Similarity
messages: Belongs to the OSBP family.

9646:CLDND2
gene id: 9646:CLDND2
uniprot id: D2HYM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9646:ANAPC11
gene id: 9646:ANAPC11
uniprot id: G1MGG2
names: Similarity
messages: Belongs to the RING-box family.

9646:TRIM2
gene id: 9646:TRIM2
uniprot id: D2GXS7
uniprot id: G1MJG3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Forms homooligomers (By similarity). Interacts with TRIM3; this interaction reduces TRIM2 activity (By similarity). Interacts with myosin V; myosin V may not be a substrate for ubiquitination. Interacts with NEFL. Interacts with phosphorylated BCL2L11. Interacts with SIRPA (By similarity).
messages: RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination.
messages: The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.
messages: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity.

9646:GFOD1
gene id: 9646:GFOD1
uniprot id: D2H792
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9646:AATF
gene id: 9646:AATF
uniprot id: G1M4N3
names: Similarity
messages: Belongs to the AATF family.

9646:MED13
gene id: 9646:MED13
uniprot id: G1LQ82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9646:DDX18
gene id: 9646:DDX18
uniprot id: D2HKQ4
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9646:PKMYT1
gene id: 9646:PKMYT1
uniprot id: G1LP64
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:RAD23B
gene id: 9646:RAD23B
uniprot id: G1MF30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9646:RAF1
gene id: 9646:RAF1
uniprot id: D2HGN5
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9646:LHB
gene id: 9646:LHB
uniprot id: Q8WN18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
messages: Secreted

9646:RPS6KB2
gene id: 9646:RPS6KB2
uniprot id: G1L1X5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9646:BCKDK
gene id: 9646:BCKDK
uniprot id: D2HQM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9646:LOC100472904
gene id: 9646:LOC100472904
uniprot id: D2I8A4
names: Similarity
messages: Belongs to the BEX family.

9646:YARS1
gene id: 9646:YARS1
uniprot id: G1LLU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Nucleus

9646:MRPL10
gene id: 9646:MRPL10
uniprot id: G1LDK3
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

9646:IFNG
gene id: 9646:IFNG
uniprot id: C8CBV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9646:ARL6
gene id: 9646:ARL6
uniprot id: G1M4X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9646:TAS2R4
gene id: 9646:TAS2R4
uniprot id: D2HHN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9646:YEATS2
gene id: 9646:YEATS2
uniprot id: D2H2B5
names: Subcellular Location Annotation
messages: Nucleus

9646:TMEM263
gene id: 9646:TMEM263
uniprot id: G1L7M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

9646:NOP2
gene id: 9646:NOP2
uniprot id: G1M6U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

9646:RPL22L1
gene id: 9646:RPL22L1
uniprot id: G1LDK9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9646:HMGB2
gene id: 9646:HMGB2
uniprot id: D2GUW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9646:PDLIM3
gene id: 9646:PDLIM3
uniprot id: A0A7N5K265
uniprot id: D2HM24
names: Subcellular Location Annotation
messages: Z line

9646:DLX3
gene id: 9646:DLX3
uniprot id: D2HMY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9646:BPGM
gene id: 9646:BPGM
uniprot id: G1MCI3
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9646:PPOX
gene id: 9646:PPOX
uniprot id: D2I0T3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

9646:PFDN5
gene id: 9646:PFDN5
uniprot id: A0A7N5P899
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9646:GJB4
gene id: 9646:GJB4
uniprot id: D2H620
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9646:MAPKAPK3
gene id: 9646:MAPKAPK3
uniprot id: D2HER6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:CCT6B
gene id: 9646:CCT6B
uniprot id: G1M7G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9646:SSTR1
gene id: 9646:SSTR1
uniprot id: D2HTA1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:ELOA
gene id: 9646:ELOA
uniprot id: G1LT22
names: Subcellular Location Annotation
messages: Nucleus

9646:IZUMO1R
gene id: 9646:IZUMO1R
uniprot id: G1LZN7
names: Similarity
messages: Belongs to the folate receptor family.

9646:MAPK14
gene id: 9646:MAPK14
uniprot id: A0A7N5JK52
uniprot id: A0A7N5KIZ5
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9646:DPP3
gene id: 9646:DPP3
uniprot id: D2HYB0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

9646:RELL2
gene id: 9646:RELL2
uniprot id: A0A7N5JG68
names: Similarity
messages: Belongs to the RELT family.

9646:FAM160A1
gene id: 9646:FAM160A1
uniprot id: G1MJF1
names: Similarity
messages: Belongs to the FHIP family.

9646:NDUFB5
gene id: 9646:NDUFB5
uniprot id: D2GUD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9646:TMEM242
gene id: 9646:TMEM242
uniprot id: G1LSZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9646:FAM136A
gene id: 9646:FAM136A
uniprot id: D2H0E1
names: Similarity
messages: Belongs to the FAM136 family.

9646:LOC100472448
gene id: 9646:LOC100472448
uniprot id: D2HU48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TRPV6
gene id: 9646:TRPV6
uniprot id: D2HP39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:ITGB8
gene id: 9646:ITGB8
uniprot id: D2H1I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

9646:SHROOM3
gene id: 9646:SHROOM3
uniprot id: A0A7N5JZR7
uniprot id: G1LZB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9646:SYNCRIP
gene id: 9646:SYNCRIP
uniprot id: D2HLE8
names: Subcellular Location Annotation
messages: Cytoplasm

9646:PIGL
gene id: 9646:PIGL
uniprot id: A0A7N5K667
uniprot id: D2HFN9
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

9646:MORF4L2
gene id: 9646:MORF4L2
uniprot id: D2HTN4
names: Subcellular Location Annotation
messages: Nucleus

9646:CNGA4
gene id: 9646:CNGA4
uniprot id: D2HR69
names: Subcellular Location Annotation
messages: Membrane

9646:PAX9
gene id: 9646:PAX9
uniprot id: G1L841
names: Subcellular Location Annotation
messages: Nucleus

9646:WASHC5
gene id: 9646:WASHC5
uniprot id: A0A7N5JFD5
uniprot id: G1L0H7
names: Similarity
messages: Belongs to the strumpellin family.

9646:GSC
gene id: 9646:GSC
uniprot id: D2HEN0
names: Subcellular Location Annotation
messages: Nucleus

9646:MINAR2
gene id: 9646:MINAR2
uniprot id: G1LDS6
names: Similarity
messages: Belongs to the MINAR family.

9646:INTS10
gene id: 9646:INTS10
uniprot id: A0A7N5P5F5
uniprot id: G1LDX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9646:LOC100475582
gene id: 9646:LOC100475582
uniprot id: A0A7N5JHP7
uniprot id: D2HQM1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

9646:DCT
gene id: 9646:DCT
uniprot id: D2H9Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9646:OTX2
gene id: 9646:OTX2
uniprot id: D2GVQ2
uniprot id: G1L6C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9646:LOC100477514
gene id: 9646:LOC100477514
uniprot id: D2I465
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:MED8
gene id: 9646:MED8
uniprot id: G1L470
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9646:WDR48
gene id: 9646:WDR48
uniprot id: G1L2W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Late endosome

9646:RDX
gene id: 9646:RDX
uniprot id: A0A7N5J969
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9646:BRIX1
gene id: 9646:BRIX1
uniprot id: D2HC18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9646:C13H20orf27
gene id: 9646:C13H20orf27
uniprot id: A0A7N5JRV7
names: Similarity
messages: Belongs to the ADISSP family.

9646:FYN
gene id: 9646:FYN
uniprot id: A0A7N5JD06
uniprot id: A0A7N5JN10
uniprot id: D2H640
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9646:PARL
gene id: 9646:PARL
uniprot id: D2H2B4
names: Subcellular Location Annotation
messages: Membrane

9646:PSMB8
gene id: 9646:PSMB8
uniprot id: D2GZ14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9646:C16H11orf94
gene id: 9646:C16H11orf94
uniprot id: D2HJ50
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with SPPL2C (via active sites); the interaction stabilizes FREY1 protein and inhibits SPPL2C proteolytic activity. Interacts with IZUMO1; the interaction retains IZUMO1 at the endoplasmic reticulum membrane and coordinates IZUMO1 complex assembly.
messages: Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome. Through the interaction with SPPL2C, inhibits its intramembrane protease activity directly accessing the catalytic center of an I-CLiP.

9646:FABP5
gene id: 9646:FABP5
uniprot id: J7FAN4
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9646:CCDC85B
gene id: 9646:CCDC85B
uniprot id: D2H4N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9646:MRPS11
gene id: 9646:MRPS11
uniprot id: G1M295
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9646:NPC2
gene id: 9646:NPC2
uniprot id: A0A7N5K6P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9646:GDPD3
gene id: 9646:GDPD3
uniprot id: D2HX49
uniprot id: G1M9U8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9646:CX3CR1
gene id: 9646:CX3CR1
uniprot id: G1LQR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9646:AP1G2
gene id: 9646:AP1G2
uniprot id: D2HG65
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9646:LOC100465086
gene id: 9646:LOC100465086
uniprot id: D2HI19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ATF2
gene id: 9646:ATF2
uniprot id: A0A7N5K1Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a dimer and can form a homodimer in the absence of DNA.
messages: Nucleus
messages: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3').

9646:SLC11A2
gene id: 9646:SLC11A2
uniprot id: G1L645
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

9646:WFIKKN2
gene id: 9646:WFIKKN2
uniprot id: D2HTT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WFIKKN family.
messages: Secreted

9646:ESCO1
gene id: 9646:ESCO1
uniprot id: D2HZR2
names: Subcellular Location Annotation
messages: Nucleus

9646:ATAD1
gene id: 9646:ATAD1
uniprot id: A0A7N5P0A3
names: Similarity
messages: Belongs to the AAA ATPase family.

9646:SMIM7
gene id: 9646:SMIM7
uniprot id: A0A7N5JLY3
names: Similarity
messages: Belongs to the SMIM7 family.

9646:ENY2
gene id: 9646:ENY2
uniprot id: A0A7N5K0V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9646:BLOC1S2
gene id: 9646:BLOC1S2
uniprot id: G1LJR2
names: Similarity
messages: Belongs to the BLOC1S2 family.

9646:TYRO3
gene id: 9646:TYRO3
uniprot id: A0A7N5P830
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

9646:IL7
gene id: 9646:IL7
uniprot id: G1LMV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Secreted

9646:MGRN1
gene id: 9646:MGRN1
uniprot id: A0A7N5JKM0
uniprot id: A0A7N5KAF8
uniprot id: A0A7N5KFA3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9646:NEK9
gene id: 9646:NEK9
uniprot id: D2GZX8
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9646:DLX4
gene id: 9646:DLX4
uniprot id: D2HMY2
names: Subcellular Location Annotation
messages: Nucleus

9646:ARRDC5
gene id: 9646:ARRDC5
uniprot id: D2I2H1
names: Similarity
messages: Belongs to the arrestin family.

9646:TIGD6
gene id: 9646:TIGD6
uniprot id: D2H8M5
names: Subcellular Location Annotation
messages: Nucleus

9646:TMOD2
gene id: 9646:TMOD2
uniprot id: G1LRW5
names: Subcellular Location Annotation
messages: cytoskeleton

9646:EIF3G
gene id: 9646:EIF3G
uniprot id: G1LZU6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9646:LOC100479766
gene id: 9646:LOC100479766
uniprot id: A0A7N5P672
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

9646:LIN28A
gene id: 9646:LIN28A
uniprot id: D2GWG9
names: Similarity
messages: Belongs to the lin-28 family.

9646:RNF141
gene id: 9646:RNF141
uniprot id: D2H3H2
names: Function
messages: May be involved in spermatogenesis.

9646:TIMM17B
gene id: 9646:TIMM17B
uniprot id: A0A7N5P4H4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

9646:GATM
gene id: 9646:GATM
uniprot id: G1M1W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain.

9646:PDIA3
gene id: 9646:PDIA3
uniprot id: D2GW48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9646:LOC100476462
gene id: 9646:LOC100476462
uniprot id: A0A7N5KIH8
uniprot id: G1MKE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9646:FGF17
gene id: 9646:FGF17
uniprot id: G1LA01
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9646:TEKT3
gene id: 9646:TEKT3
uniprot id: G1LG05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9646:LOC100481490
gene id: 9646:LOC100481490
uniprot id: G1ML99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCO1/2 family.
messages: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
messages: Homodimer.
messages: Mitochondrion inner membrane

9646:LOC100471215
gene id: 9646:LOC100471215
uniprot id: D2HU38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CHMP2B
gene id: 9646:CHMP2B
uniprot id: G1LL36
names: Similarity
messages: Belongs to the SNF7 family.

9646:LOC100468297
gene id: 9646:LOC100468297
uniprot id: A0A7N5KF74
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9646:GPR34
gene id: 9646:GPR34
uniprot id: G1MMN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor.

9646:FOXN4
gene id: 9646:FOXN4
uniprot id: D2HGL5
names: Subcellular Location Annotation
messages: Nucleus

9646:TMEM267
gene id: 9646:TMEM267
uniprot id: D2HHR2
names: Subcellular Location Annotation
messages: Membrane

9646:NIP7
gene id: 9646:NIP7
uniprot id: D2HLI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP7 family.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

9646:B3GNT9
gene id: 9646:B3GNT9
uniprot id: A0A7N5P783
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:LOC100483898
gene id: 9646:LOC100483898
uniprot id: G1L7C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9646:CUL2
gene id: 9646:CUL2
uniprot id: D2HSC2
names: Similarity
messages: Belongs to the cullin family.

9646:LOC100479522
gene id: 9646:LOC100479522
uniprot id: G1L2V2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9646:FAM183A
gene id: 9646:FAM183A
uniprot id: G1L4S8
names: Similarity
messages: Belongs to the CFAP144 family.

9646:LOC100471057
gene id: 9646:LOC100471057
uniprot id: G1L971
names: Subcellular Location Annotation
messages: Nucleus

9646:FGF6
gene id: 9646:FGF6
uniprot id: D2HEJ8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9646:SMCO2
gene id: 9646:SMCO2
uniprot id: G1LYP6
names: Subcellular Location Annotation
messages: Membrane

9646:TUBA8
gene id: 9646:TUBA8
uniprot id: G1MGF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9646:CDC42EP4
gene id: 9646:CDC42EP4
uniprot id: D2HUC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9646:RBPJ
gene id: 9646:RBPJ
uniprot id: G1MIC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9646:MON2
gene id: 9646:MON2
uniprot id: D2HCH6
uniprot id: G1LTJ1
names: Similarity
messages: Belongs to the MON2 family.

9646:GSTCD
gene id: 9646:GSTCD
uniprot id: D2HPF3
names: Similarity
messages: Belongs to the GSTCD family.

9646:TBCCD1
gene id: 9646:TBCCD1
uniprot id: D2H077
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

9646:KARS1
gene id: 9646:KARS1
uniprot id: D2HY20
uniprot id: G1LFN2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9646:ACAD8
gene id: 9646:ACAD8
uniprot id: A0A7N5JHS6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9646:BPIFC
gene id: 9646:BPIFC
uniprot id: D2HHA9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9646:FIGN
gene id: 9646:FIGN
uniprot id: G1M6V6
names: Similarity
messages: Belongs to the AAA ATPase family.

9646:ETS1
gene id: 9646:ETS1
uniprot id: G1L7C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9646:XPNPEP1
gene id: 9646:XPNPEP1
uniprot id: D2HRH3
names: Similarity
messages: Belongs to the peptidase M24B family.

9646:SERPINB10
gene id: 9646:SERPINB10
uniprot id: D2HUS9
names: Similarity
messages: Belongs to the serpin family.

9646:RNASE1
gene id: 9646:RNASE1
uniprot id: D2HYD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9646:PPIP5K2
gene id: 9646:PPIP5K2
uniprot id: A0A7N5JFW0
uniprot id: A0A7N5KC29
uniprot id: A0A7N5KLD3
uniprot id: G1MET4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9646:CLDN1
gene id: 9646:CLDN1
uniprot id: D2H059
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9646:PHF20L1
gene id: 9646:PHF20L1
uniprot id: G1M2M1
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100484314
gene id: 9646:LOC100484314
uniprot id: A0A7N5KEB3
uniprot id: D2I587
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9646:EHHADH
gene id: 9646:EHHADH
uniprot id: G1MEK3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9646:FUNDC1
gene id: 9646:FUNDC1
uniprot id: G1LUN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9646:GRIK1
gene id: 9646:GRIK1
uniprot id: A0A7N5KDP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9646:TET1
gene id: 9646:TET1
uniprot id: D2GXI8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9646:ATP5IF1
gene id: 9646:ATP5IF1
uniprot id: A0A7N5P989
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9646:PCID2
gene id: 9646:PCID2
uniprot id: G1LUL1
names: Similarity
messages: Belongs to the CSN12 family.

9646:IER2
gene id: 9646:IER2
uniprot id: D2HG26
names: Similarity
messages: Belongs to the IER family.

9646:FAM133A
gene id: 9646:FAM133A
uniprot id: G1MLF6
names: Similarity
messages: Belongs to the FAM133 family.

9646:BMP4
gene id: 9646:BMP4
uniprot id: D2HCK9
names: Similarity
messages: Belongs to the TGF-beta family.

9646:ASF1A
gene id: 9646:ASF1A
uniprot id: G1LA84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9646:PDCD5
gene id: 9646:PDCD5
uniprot id: D2H3A5
names: Similarity
messages: Belongs to the PDCD5 family.

9646:CPB1
gene id: 9646:CPB1
uniprot id: D2HWE0
names: Similarity
messages: Belongs to the peptidase M14 family.

9646:MAPK10
gene id: 9646:MAPK10
uniprot id: A0A7N5KBI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9646:IGF2BP1
gene id: 9646:IGF2BP1
uniprot id: D2H577
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9646:DAD1
gene id: 9646:DAD1
uniprot id: D2HTV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9646:CCSER2
gene id: 9646:CCSER2
uniprot id: A0A7N5JAB1
uniprot id: D2H1J3
names: Similarity
messages: Belongs to the CCSER family.

9646:JPT2
gene id: 9646:JPT2
uniprot id: G1LNM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9646:METAP1
gene id: 9646:METAP1
uniprot id: G1M5Q5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9646:CCR8
gene id: 9646:CCR8
uniprot id: D2HZM8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:ACTL9
gene id: 9646:ACTL9
uniprot id: D2HZT2
names: Similarity
messages: Belongs to the actin family.

9646:AGA
gene id: 9646:AGA
uniprot id: G1LAI5
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9646:MMP20
gene id: 9646:MMP20
uniprot id: D2HIG8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9646:USP33
gene id: 9646:USP33
uniprot id: A0A7N5JNV9
uniprot id: G1LL63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9646:CXCL10
gene id: 9646:CXCL10
uniprot id: A0A7N5JM26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9646:CTPS1
gene id: 9646:CTPS1
uniprot id: D2I190
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9646:MINAR1
gene id: 9646:MINAR1
uniprot id: D2HL04
names: Similarity
messages: Belongs to the MINAR family.

9646:ATOH7
gene id: 9646:ATOH7
uniprot id: D2GXJ4
names: Subcellular Location Annotation
messages: Nucleus
messages: Perikaryon
messages: axon

9646:GGT5
gene id: 9646:GGT5
uniprot id: G1M5J8
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

9646:LAPTM5
gene id: 9646:LAPTM5
uniprot id: D2HNI0
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9646:TDRD7
gene id: 9646:TDRD7
uniprot id: G1LE45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
messages: Cytoplasm
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.

9646:POLR2J
gene id: 9646:POLR2J
uniprot id: G1MAF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

9646:FAM199X
gene id: 9646:FAM199X
uniprot id: D2I4E6
names: Similarity
messages: Belongs to the FAM199 family.

9646:AK4
gene id: 9646:AK4
uniprot id: D2HQE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Mitochondrion matrix

9646:G6PC
gene id: 9646:G6PC
uniprot id: D2I4E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9646:DAPK2
gene id: 9646:DAPK2
uniprot id: G1L6P1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:TOR2A
gene id: 9646:TOR2A
uniprot id: D2H3Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9646:DPCD
gene id: 9646:DPCD
uniprot id: G1MGY5
names: Similarity
messages: Belongs to the DPCD family.

9646:IL4
gene id: 9646:IL4
uniprot id: Q3S4V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
messages: Secreted

9646:TMEM168
gene id: 9646:TMEM168
uniprot id: D2H0S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane
messages: Nucleus membrane

9646:SLC25A44
gene id: 9646:SLC25A44
uniprot id: D2HW65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:MAT2A
gene id: 9646:MAT2A
uniprot id: A0A7N5JA28
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9646:TAF9
gene id: 9646:TAF9
uniprot id: D2H2U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9646:TGM1
gene id: 9646:TGM1
uniprot id: D2HG44
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9646:CPNE2
gene id: 9646:CPNE2
uniprot id: D2GTW4
names: Similarity
messages: Belongs to the copine family.

9646:POLR3K
gene id: 9646:POLR3K
uniprot id: D2HDU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: nucleolus

9646:IER3IP1
gene id: 9646:IER3IP1
uniprot id: A0A7N5JM38
names: Similarity
messages: Belongs to the YOS1 family.

9646:LOC100478515
gene id: 9646:LOC100478515
uniprot id: A0A7N5K3U2
names: Similarity
messages: Belongs to the MS4A family.

9646:SMG1
gene id: 9646:SMG1
uniprot id: A0A7N5KD81
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9646:LOC105241292
gene id: 9646:LOC105241292
uniprot id: A0A7N5JJA2
names: Similarity
messages: Belongs to the MS4A family.

9646:PITX3
gene id: 9646:PITX3
uniprot id: G1MH59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9646:RAB3C
gene id: 9646:RAB3C
uniprot id: A0A7N5JWR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9646:AP3M2
gene id: 9646:AP3M2
uniprot id: D2H984
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

9646:S100G
gene id: 9646:S100G
uniprot id: D2HDU5
names: Similarity
messages: Belongs to the S-100 family.

9646:STRADB
gene id: 9646:STRADB
uniprot id: A0A7N5P4Q9
uniprot id: G1LHX1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9646:SLU7
gene id: 9646:SLU7
uniprot id: D2GUJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9646:LOC100478655
gene id: 9646:LOC100478655
uniprot id: G1LR62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9646:RFX6
gene id: 9646:RFX6
uniprot id: D2HNW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RFX family.
messages: Interacts with RFX3.
messages: Nucleus
messages: Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription.

9646:OPRL1
gene id: 9646:OPRL1
uniprot id: D2HT41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

9646:PPP1R1C
gene id: 9646:PPP1R1C
uniprot id: A0A7N5P8Q1
uniprot id: G1L8T1
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9646:LOC100463617
gene id: 9646:LOC100463617
uniprot id: G1MM28
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:DBX1
gene id: 9646:DBX1
uniprot id: G1LDD2
names: Subcellular Location Annotation
messages: Nucleus

9646:PIK3IP1
gene id: 9646:PIK3IP1
uniprot id: G1LKJ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:TIPRL
gene id: 9646:TIPRL
uniprot id: D2I6H5
names: Similarity
messages: Belongs to the TIP41 family.

9646:ATE1
gene id: 9646:ATE1
uniprot id: G1LWQ0
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9646:LOC100478374
gene id: 9646:LOC100478374
uniprot id: D2I4Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC100476759
gene id: 9646:LOC100476759
uniprot id: G1L0V5
names: Similarity
messages: Belongs to the MS4A family.

9646:TENT5D
gene id: 9646:TENT5D
uniprot id: G1MKZ1
names: Similarity
messages: Belongs to the TENT family.

9646:RPL37A
gene id: 9646:RPL37A
uniprot id: A0A7N5JEV2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9646:WASF3
gene id: 9646:WASF3
uniprot id: A0A7N5JJI1
uniprot id: D2HP85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9646:TXNL4B
gene id: 9646:TXNL4B
uniprot id: D2HMK1
names: Similarity
messages: Belongs to the DIM1 family.

9646:LOC109489374
gene id: 9646:LOC109489374
uniprot id: A0A7N5JF78
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9646:DRD2
gene id: 9646:DRD2
uniprot id: A0A7N5JMU2
uniprot id: G1LHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9646:LOC100478779
gene id: 9646:LOC100478779
uniprot id: D2I473
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:S1PR1
gene id: 9646:S1PR1
uniprot id: D2HAQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:PRKACB
gene id: 9646:PRKACB
uniprot id: A0A7N5JV97
uniprot id: A0A7N5P3U8
uniprot id: D2HVX2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9646:GC
gene id: 9646:GC
uniprot id: G1LHM6
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9646:ACTL6A
gene id: 9646:ACTL6A
uniprot id: G1LWH1
names: Similarity
messages: Belongs to the actin family.

9646:PPP1R12A
gene id: 9646:PPP1R12A
uniprot id: A0A7N5P5R6
uniprot id: G1M406
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9646:SF3B6
gene id: 9646:SF3B6
uniprot id: G1L7R7
names: Subcellular Location Annotation
messages: Nucleus

9646:KEG54 p08
gene id: 9646:KEG54_p08
uniprot id: A5JFK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

9646:PRUNE1
gene id: 9646:PRUNE1
uniprot id: G1L2J9
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9646:SND1
gene id: 9646:SND1
uniprot id: G1LDP5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9646:PISD
gene id: 9646:PISD
uniprot id: A0A7N5K2N2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9646:KCNA2
gene id: 9646:KCNA2
uniprot id: D2HZL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: lamellipodium membrane
messages: paranodal septate junction
messages: synaptosome

9646:POU1F1
gene id: 9646:POU1F1
uniprot id: A0A7N5KPA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9646:CPLANE2
gene id: 9646:CPLANE2
uniprot id: G1LYM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

9646:NTMT1
gene id: 9646:NTMT1
uniprot id: D2H163
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. NTM1 family.
messages: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
messages: Nucleus

9646:YPEL3
gene id: 9646:YPEL3
uniprot id: G1M9S6
names: Similarity
messages: Belongs to the yippee family.

9646:IAPP
gene id: 9646:IAPP
uniprot id: G1L224
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted
messages: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

9646:GLS2
gene id: 9646:GLS2
uniprot id: D2H360
names: Similarity
messages: Belongs to the glutaminase family.

9646:DNMT3B
gene id: 9646:DNMT3B
uniprot id: G1M3V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9646:PDE4B
gene id: 9646:PDE4B
uniprot id: A0A7N5P511
uniprot id: G1MI93
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9646:OIP5
gene id: 9646:OIP5
uniprot id: A0A7N5K262
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9646:SLC2A12
gene id: 9646:SLC2A12
uniprot id: A0A7N5JNF4
uniprot id: D2HJ42
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9646:FAM124B
gene id: 9646:FAM124B
uniprot id: D2H9R1
names: Similarity
messages: Belongs to the FAM124 family.

9646:LOC100474256
gene id: 9646:LOC100474256
uniprot id: D2I7D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ING2
gene id: 9646:ING2
uniprot id: D2GY56
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9646:GLMP
gene id: 9646:GLMP
uniprot id: D2HW69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9646:EGFL7
gene id: 9646:EGFL7
uniprot id: G1LB99
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:FASLG
gene id: 9646:FASLG
uniprot id: D2H5H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9646:CPN1
gene id: 9646:CPN1
uniprot id: G1LKA1
names: Similarity
messages: Belongs to the peptidase M14 family.

9646:NDUFV3
gene id: 9646:NDUFV3
uniprot id: G1L4V0
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

9646:SLC35E1
gene id: 9646:SLC35E1
uniprot id: D2GUZ3
names: Subcellular Location Annotation
messages: Membrane

9646:KCNS3
gene id: 9646:KCNS3
uniprot id: D2H0L8
names: Subcellular Location Annotation
messages: Membrane

9646:MCM2
gene id: 9646:MCM2
uniprot id: G1M927
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9646:KCNJ2
gene id: 9646:KCNJ2
uniprot id: D2HP90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Membrane

9646:PRICKLE2
gene id: 9646:PRICKLE2
uniprot id: D2HL65
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9646:CNFN
gene id: 9646:CNFN
uniprot id: D2HNH5
names: Similarity
messages: Belongs to the cornifelin family.

9646:ADGRG6
gene id: 9646:ADGRG6
uniprot id: A0A7N5K657
uniprot id: A0A7N5P249
uniprot id: G1LZ23
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:UBN1
gene id: 9646:UBN1
uniprot id: G1L4E5
names: Similarity
messages: Belongs to the ubinuclein family.

9646:IL17RA
gene id: 9646:IL17RA
uniprot id: A0A7N5KAM7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:SSR3
gene id: 9646:SSR3
uniprot id: A0A7N5KN28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9646:AHDC1
gene id: 9646:AHDC1
uniprot id: D2GWJ0
names: Subcellular Location Annotation
messages: Nucleus

9646:TOB1
gene id: 9646:TOB1
uniprot id: D2HTT8
names: Similarity
messages: Belongs to the BTG family.

9646:REV1
gene id: 9646:REV1
uniprot id: A0A7N5JF38
uniprot id: G1M3Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

9646:GRB2
gene id: 9646:GRB2
uniprot id: D2HD44
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9646:FOXO4
gene id: 9646:FOXO4
uniprot id: G1MBP3
names: Subcellular Location Annotation
messages: Nucleus

9646:CA13
gene id: 9646:CA13
uniprot id: A0A7N5J9T4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9646:MAST3
gene id: 9646:MAST3
uniprot id: A0A7N5JQ64
uniprot id: A0A7N5JZE1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9646:LOC100471975
gene id: 9646:LOC100471975
uniprot id: D2I550
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TRMT13
gene id: 9646:TRMT13
uniprot id: D2HFE7
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9646:LZTFL1
gene id: 9646:LZTFL1
uniprot id: G1M0S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9646:ACTG2
gene id: 9646:ACTG2
uniprot id: D2HH73
names: Similarity
messages: Belongs to the actin family.

9646:MIOX
gene id: 9646:MIOX
uniprot id: G1L848
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

9646:LHX2
gene id: 9646:LHX2
uniprot id: D2HDG3
names: Subcellular Location Annotation
messages: Nucleus

9646:CCL24
gene id: 9646:CCL24
uniprot id: A0A7N5JCF2
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9646:RARRES2
gene id: 9646:RARRES2
uniprot id: D2HN07
names: Subcellular Location Annotation
messages: Secreted

9646:SDR9C7
gene id: 9646:SDR9C7
uniprot id: D2H367
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:TIGD2
gene id: 9646:TIGD2
uniprot id: D2H7I1
names: Subcellular Location Annotation
messages: Nucleus

9646:ALPL
gene id: 9646:ALPL
uniprot id: G1M6R5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9646:PPP2R2B
gene id: 9646:PPP2R2B
uniprot id: A0A7N5JQK6
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9646:ACMSD
gene id: 9646:ACMSD
uniprot id: A0A7N5JHJ2
uniprot id: G1MD21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9646:LOC100466688
gene id: 9646:LOC100466688
uniprot id: D2HWJ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:PDE5A
gene id: 9646:PDE5A
uniprot id: G1MET3
uniprot id: G1MET6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9646:SDHC
gene id: 9646:SDHC
uniprot id: A0A7N5KM32
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9646:GPAT3
gene id: 9646:GPAT3
uniprot id: D2GUE1
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9646:OGDHL
gene id: 9646:OGDHL
uniprot id: D2HUG6
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9646:STX3
gene id: 9646:STX3
uniprot id: A0A7N5P1Y0
names: Similarity
messages: Belongs to the syntaxin family.

9646:DCTN6
gene id: 9646:DCTN6
uniprot id: A0A7N5KK74
uniprot id: A0A7N5P636
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
messages: cytoskeleton

9646:OPALIN
gene id: 9646:OPALIN
uniprot id: A0A7N5KJH9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

9646:PPP2R2C
gene id: 9646:PPP2R2C
uniprot id: A0A7N5K665
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9646:ADCK2
gene id: 9646:ADCK2
uniprot id: G1MHJ0
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9646:RSPO3
gene id: 9646:RSPO3
uniprot id: G1LSB8
names: Similarity
messages: Belongs to the R-spondin family.

9646:PODXL
gene id: 9646:PODXL
uniprot id: G1LGV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the podocalyxin family.
messages: Cell membrane
messages: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
messages: Membrane
messages: Membrane raft
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

9646:TRUB1
gene id: 9646:TRUB1
uniprot id: G1M8S5
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9646:SH2D1A
gene id: 9646:SH2D1A
uniprot id: D2HJ45
names: Subcellular Location Annotation
messages: Cytoplasm

9646:UBE2F
gene id: 9646:UBE2F
uniprot id: A0A7N5KAT6
uniprot id: G1LPN3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9646:LOC100475277
gene id: 9646:LOC100475277
uniprot id: D2I3R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LEP
gene id: 9646:LEP
uniprot id: A0A7N5P1L2
uniprot id: B0ZE72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

9646:CKS1B
gene id: 9646:CKS1B
uniprot id: A0A7N5JH98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9646:CCT2
gene id: 9646:CCT2
uniprot id: G1LZI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9646:SLC17A6
gene id: 9646:SLC17A6
uniprot id: D2GY93
names: Subcellular Location Annotation
messages: Membrane

9646:AK3
gene id: 9646:AK3
uniprot id: D2HPJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Mitochondrion matrix

9646:TCN2
gene id: 9646:TCN2
uniprot id: A0A7N5JXU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9646:TNFRSF14
gene id: 9646:TNFRSF14
uniprot id: G1M3X9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:RPS23
gene id: 9646:RPS23
uniprot id: F2X222
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Rough endoplasmic reticulum

9646:LGMN
gene id: 9646:LGMN
uniprot id: G1M534
names: Similarity
messages: Belongs to the peptidase C13 family.

9646:TTC21B
gene id: 9646:TTC21B
uniprot id: G1MB04
names: Similarity
messages: Belongs to the TTC21 family.

9646:SSR2
gene id: 9646:SSR2
uniprot id: A0A7N5JSZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9646:ZNF830
gene id: 9646:ZNF830
uniprot id: D2HMK5
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus speckle

9646:CUL4B
gene id: 9646:CUL4B
uniprot id: G1L043
names: Similarity
messages: Belongs to the cullin family.

9646:TAS2R1
gene id: 9646:TAS2R1
uniprot id: D2H9X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9646:MRFAP1
gene id: 9646:MRFAP1
uniprot id: D2I7X6
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9646:RPL6
gene id: 9646:RPL6
uniprot id: D2HRU8
uniprot id: F2X236
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9646:GLRA1
gene id: 9646:GLRA1
uniprot id: G1LMJ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

9646:PSME4
gene id: 9646:PSME4
uniprot id: D2GY87
names: Similarity
messages: Belongs to the BLM10 family.

9646:AFM
gene id: 9646:AFM
uniprot id: G1LE42
names: Subcellular Location Annotation
messages: Secreted

9646:KEG54 p07
gene id: 9646:KEG54_p07
uniprot id: A5JFK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9646:HSD17B10
gene id: 9646:HSD17B10
uniprot id: G1LEJ1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:ZC2HC1C
gene id: 9646:ZC2HC1C
uniprot id: G1MJ32
names: Similarity
messages: Belongs to the ZC2HC1 family.

9646:CCL19
gene id: 9646:CCL19
uniprot id: G1LK30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9646:UGDH
gene id: 9646:UGDH
uniprot id: A0A7N5JAE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

9646:AGPAT1
gene id: 9646:AGPAT1
uniprot id: G1L6S2
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9646:CHEK1
gene id: 9646:CHEK1
uniprot id: A0A7N5KJU4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9646:TEF
gene id: 9646:TEF
uniprot id: A0A7N5JMJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9646:ASZ1
gene id: 9646:ASZ1
uniprot id: D2H6R1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9646:POLR2E
gene id: 9646:POLR2E
uniprot id: G1L8X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

9646:TMEM225B
gene id: 9646:TMEM225B
uniprot id: G1LHY2
names: Subcellular Location Annotation
messages: Membrane

9646:FNIP1
gene id: 9646:FNIP1
uniprot id: A0A7N5JPJ5
uniprot id: G1MGW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9646:NUPR1
gene id: 9646:NUPR1
uniprot id: A0A7N5J9Q0
names: Similarity
messages: Belongs to the NUPR family.

9646:PTGR1
gene id: 9646:PTGR1
uniprot id: D2H4E4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9646:INTS12
gene id: 9646:INTS12
uniprot id: D2HPF2
names: Similarity
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

9646:SPRTN
gene id: 9646:SPRTN
uniprot id: D2H5X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9646:DDX47
gene id: 9646:DDX47
uniprot id: G1LW60
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9646:PRC1
gene id: 9646:PRC1
uniprot id: A0A7N5P329
uniprot id: G1M4Z4
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

9646:SSTR5
gene id: 9646:SSTR5
uniprot id: D2HDY0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:NAT10
gene id: 9646:NAT10
uniprot id: A0A7N5KGN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9646:THEMIS2
gene id: 9646:THEMIS2
uniprot id: G1LX98
names: Similarity
messages: Belongs to the themis family.

9646:SLC39A1
gene id: 9646:SLC39A1
uniprot id: D2HJQ0
names: Subcellular Location Annotation
messages: Membrane

9646:ROMO1
gene id: 9646:ROMO1
uniprot id: D2H457
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9646:AK1
gene id: 9646:AK1
uniprot id: G1M9F0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

9646:TRAPPC6B
gene id: 9646:TRAPPC6B
uniprot id: G1LB30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9646:INHBC
gene id: 9646:INHBC
uniprot id: D2H381
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9646:TMEM106C
gene id: 9646:TMEM106C
uniprot id: D2HE74
names: Similarity
messages: Belongs to the TMEM106 family.

9646:RAB33B
gene id: 9646:RAB33B
uniprot id: D2H3G3
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9646:SST
gene id: 9646:SST
uniprot id: D2H067
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9646:RDH10
gene id: 9646:RDH10
uniprot id: D2HVD9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:DNAJB12
gene id: 9646:DNAJB12
uniprot id: D2HZB1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:SCAMP3
gene id: 9646:SCAMP3
uniprot id: D2HZL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9646:NID1
gene id: 9646:NID1
uniprot id: D2HZI0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9646:CACNG7
gene id: 9646:CACNG7
uniprot id: D2HYP9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

9646:BMP2
gene id: 9646:BMP2
uniprot id: D2HR91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9646:CTSS
gene id: 9646:CTSS
uniprot id: G1L3B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9646:NOB1
gene id: 9646:NOB1
uniprot id: D2HMP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: Nucleus

9646:TK2
gene id: 9646:TK2
uniprot id: A0A7N5P5F6
names: Similarity
messages: Belongs to the DCK/DGK family.

9646:LOC100467660
gene id: 9646:LOC100467660
uniprot id: A0A7N5JQN9
uniprot id: G1LUN9
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9646:CALHM5
gene id: 9646:CALHM5
uniprot id: G1LGF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9646:TLR8
gene id: 9646:TLR8
uniprot id: G1MN77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9646:GJB5
gene id: 9646:GJB5
uniprot id: D2H621
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9646:CRP
gene id: 9646:CRP
uniprot id: A0A7N5JME2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9646:IDE
gene id: 9646:IDE
uniprot id: A0A7N5P7E7
uniprot id: D2H3D7
names: Similarity
messages: Belongs to the peptidase M16 family.

9646:RASGRP2
gene id: 9646:RASGRP2
uniprot id: A0A7N5KR88
names: Similarity
messages: Belongs to the RASGRP family.

9646:ORC1
gene id: 9646:ORC1
uniprot id: D2H2D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus

9646:MBTPS1
gene id: 9646:MBTPS1
uniprot id: D2HRI4
names: Similarity
messages: Belongs to the peptidase S8 family.

9646:BBS7
gene id: 9646:BBS7
uniprot id: G1LHM7
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9646:TXK
gene id: 9646:TXK
uniprot id: G1L8Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9646:NUDT2
gene id: 9646:NUDT2
uniprot id: A0A7N5J8G1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9646:TMTC3
gene id: 9646:TMTC3
uniprot id: D2HHQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9646:GIMD1
gene id: 9646:GIMD1
uniprot id: G1MGK4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9646:ODF1
gene id: 9646:ODF1
uniprot id: D2HJX0
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9646:MRPS33
gene id: 9646:MRPS33
uniprot id: G1M9Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9646:PPIL4
gene id: 9646:PPIL4
uniprot id: G1MIY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9646:LOC100475112
gene id: 9646:LOC100475112
uniprot id: A0A7N5K1W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9646:NDUFV2
gene id: 9646:NDUFV2
uniprot id: G1LLJ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9646:C1GALT1
gene id: 9646:C1GALT1
uniprot id: D2HD12
names: Subcellular Location Annotation
messages: Membrane

9646:RPS9
gene id: 9646:RPS9
uniprot id: D2HYR2
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9646:ACP7
gene id: 9646:ACP7
uniprot id: G1LQ26
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

9646:PRRX1
gene id: 9646:PRRX1
uniprot id: A0A7N5KP20
uniprot id: D2H9S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9646:C12H12orf43
gene id: 9646:C12H12orf43
uniprot id: G1LP35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope

9646:RPL15
gene id: 9646:RPL15
uniprot id: D2HKU3
uniprot id: D7RAF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Cytoplasm

9646:CLCN5
gene id: 9646:CLCN5
uniprot id: G1M083
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:ARHGEF3
gene id: 9646:ARHGEF3
uniprot id: A0A7N5JI25
uniprot id: A0A7N5KAE6
uniprot id: G1LYX5
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9646:GTF2E1
gene id: 9646:GTF2E1
uniprot id: D2HTQ9
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

9646:AGO1
gene id: 9646:AGO1
uniprot id: G1L139
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9646:NDUFA1
gene id: 9646:NDUFA1
uniprot id: G1KZY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9646:CD38
gene id: 9646:CD38
uniprot id: G1L452
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9646:STEAP1
gene id: 9646:STEAP1
uniprot id: D2HE07
names: Subcellular Location Annotation
messages: Membrane

9646:ATF7IP
gene id: 9646:ATF7IP
uniprot id: D2H859
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9646:LOC100468944
gene id: 9646:LOC100468944
uniprot id: D2HZU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:CPLX3
gene id: 9646:CPLX3
uniprot id: D2HKY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9646:MFSD8
gene id: 9646:MFSD8
uniprot id: G1L7J8
names: Subcellular Location Annotation
messages: Membrane

9646:SPTSSB
gene id: 9646:SPTSSB
uniprot id: D2I3N4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:EFNB1
gene id: 9646:EFNB1
uniprot id: D2H889
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:ACTR2
gene id: 9646:ACTR2
uniprot id: G1MB95
names: Similarity
messages: Belongs to the actin family.

9646:GGCX
gene id: 9646:GGCX
uniprot id: G1L651
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:CNRIP1
gene id: 9646:CNRIP1
uniprot id: D2HS15
uniprot id: G1LE54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9646:KCNF1
gene id: 9646:KCNF1
uniprot id: D2HH95
names: Subcellular Location Annotation
messages: Membrane

9646:CCNG1
gene id: 9646:CCNG1
uniprot id: D2HVU6
names: Similarity
messages: Belongs to the cyclin family.

9646:CD79B
gene id: 9646:CD79B
uniprot id: G1L8H1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:TRAPPC4
gene id: 9646:TRAPPC4
uniprot id: D2I333
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9646:SDHA
gene id: 9646:SDHA
uniprot id: G1LPI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9646:MAST4
gene id: 9646:MAST4
uniprot id: A0A7N5JW90
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9646:VPS52
gene id: 9646:VPS52
uniprot id: G1L4D9
names: Similarity
messages: Belongs to the VPS52 family.

9646:RAD1
gene id: 9646:RAD1
uniprot id: D2HC19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9646:VDR
gene id: 9646:VDR
uniprot id: D2HE73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Nucleus

9646:PARP14
gene id: 9646:PARP14
uniprot id: G1LE13
names: Similarity
messages: Belongs to the ARTD/PARP family.

9646:UTP11
gene id: 9646:UTP11
uniprot id: G1L3B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9646:NIPSNAP1
gene id: 9646:NIPSNAP1
uniprot id: G1LNG5
names: Similarity
messages: Belongs to the NipSnap family.

9646:REEP4
gene id: 9646:REEP4
uniprot id: G1L9I1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:AURKAIP1
gene id: 9646:AURKAIP1
uniprot id: D2I3Q9
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mS38 family.

9646:SMIM5
gene id: 9646:SMIM5
uniprot id: G1LSQ4
names: Subcellular Location Annotation
messages: Membrane

9646:WEE2
gene id: 9646:WEE2
uniprot id: D2HHP1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Nucleus
messages: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).
messages: Phosphorylation leads to increase its activity.

9646:CHPF
gene id: 9646:CHPF
uniprot id: D2HQR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9646:TMSB4X
gene id: 9646:TMSB4X
uniprot id: D2H0S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: cytoskeleton

9646:KCNJ15
gene id: 9646:KCNJ15
uniprot id: D2I6U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9646:RPL14
gene id: 9646:RPL14
uniprot id: F2X251
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

9646:PPAT
gene id: 9646:PPAT
uniprot id: D2H8I4
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9646:CD3D
gene id: 9646:CD3D
uniprot id: A0A7N5KGS1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:LOC100479867
gene id: 9646:LOC100479867
uniprot id: D2HX52
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9646:EIF4E2
gene id: 9646:EIF4E2
uniprot id: A0A7N5K1J9
uniprot id: G1MDG2
uniprot id: G1MDG4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9646:LIN52
gene id: 9646:LIN52
uniprot id: A0A7N5JQB2
names: Similarity
messages: Belongs to the lin-52 family.

9646:HOXB6
gene id: 9646:HOXB6
uniprot id: D2H568
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9646:GPR65
gene id: 9646:GPR65
uniprot id: D2HW49
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:EMC6
gene id: 9646:EMC6
uniprot id: D2HZP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:CCDC103
gene id: 9646:CCDC103
uniprot id: D2HCW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9646:GRB10
gene id: 9646:GRB10
uniprot id: G1LMY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9646:SOHLH2
gene id: 9646:SOHLH2
uniprot id: G1LD90
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100474600
gene id: 9646:LOC100474600
uniprot id: A0A7N5JJT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9646:LOC100472050
gene id: 9646:LOC100472050
uniprot id: A0A7N5K2K6
uniprot id: G1LFN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9646:EPYC
gene id: 9646:EPYC
uniprot id: D2HXD5
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9646:PRKAB2
gene id: 9646:PRKAB2
uniprot id: A0A7N5JAG0
uniprot id: D2I2Z7
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9646:LOC100477356
gene id: 9646:LOC100477356
uniprot id: D2I0C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:NCAPD3
gene id: 9646:NCAPD3
uniprot id: G1LL24
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the condensin-2 complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

9646:LTV1
gene id: 9646:LTV1
uniprot id: G1LYF8
names: Similarity
messages: Belongs to the LTV1 family.

9646:LOC100465533
gene id: 9646:LOC100465533
uniprot id: G1MNU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:PMS1
gene id: 9646:PMS1
uniprot id: D2HA18
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9646:NDUFAF7
gene id: 9646:NDUFAF7
uniprot id: D2H088
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

9646:PITPNM1
gene id: 9646:PITPNM1
uniprot id: G1L2C7
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9646:LOC100464523
gene id: 9646:LOC100464523
uniprot id: G1MNT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TMBIM6
gene id: 9646:TMBIM6
uniprot id: G1L2E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9646:PRKCE
gene id: 9646:PRKCE
uniprot id: A0A7N5KCC1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

9646:ATP8A1
gene id: 9646:ATP8A1
uniprot id: A0A7N5KM09
uniprot id: G1M2X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9646:MASP1
gene id: 9646:MASP1
uniprot id: A0A7N5P438
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:WNT3
gene id: 9646:WNT3
uniprot id: G1MCZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9646:TRAPPC13
gene id: 9646:TRAPPC13
uniprot id: A0A7N5JKD6
uniprot id: G1LXH6
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9646:BROX
gene id: 9646:BROX
uniprot id: G1LJV1
names: Similarity
messages: Belongs to the BROX family.

9646:CMTM6
gene id: 9646:CMTM6
uniprot id: D2HSU2
names: Subcellular Location Annotation
messages: Membrane

9646:CXCL11
gene id: 9646:CXCL11
uniprot id: A0A7N5KP95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9646:MTMR9
gene id: 9646:MTMR9
uniprot id: D2I0R1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9646:SLC39A9
gene id: 9646:SLC39A9
uniprot id: D2H5Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: perinuclear region
messages: trans-Golgi network membrane

9646:SLC25A36
gene id: 9646:SLC25A36
uniprot id: G1MDJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:SENP8
gene id: 9646:SENP8
uniprot id: G1MP05
names: Similarity
messages: Belongs to the peptidase C48 family.

9646:ZNF263
gene id: 9646:ZNF263
uniprot id: A0A7N5JF71
uniprot id: D2HQZ6
names: Subcellular Location Annotation
messages: Nucleus

9646:CDK5
gene id: 9646:CDK5
uniprot id: G1M5B9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:RGN
gene id: 9646:RGN
uniprot id: G1M307
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm
messages: Monomer.

9646:SDC2
gene id: 9646:SDC2
uniprot id: G1LLB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9646:TMEM167B
gene id: 9646:TMEM167B
uniprot id: G1LD07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:CCDC124
gene id: 9646:CCDC124
uniprot id: D2GV19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC124 family.
messages: Midbody

9646:DNASE1L3
gene id: 9646:DNASE1L3
uniprot id: G1LZS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Nucleus envelope
messages: Zymogen granule

9646:VAMP4
gene id: 9646:VAMP4
uniprot id: G1MEX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9646:SHMT1
gene id: 9646:SHMT1
uniprot id: G1LDK7
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9646:DCAF1
gene id: 9646:DCAF1
uniprot id: G1LRY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPRBP/DCAF1 family.
messages: Nucleus

9646:BMP15
gene id: 9646:BMP15
uniprot id: D2I5P3
names: Similarity
messages: Belongs to the TGF-beta family.

9646:MALL
gene id: 9646:MALL
uniprot id: G1LT13
names: Subcellular Location Annotation
messages: Membrane

9646:PRKCG
gene id: 9646:PRKCG
uniprot id: D2HYP8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cytoplasm
messages: Membrane

9646:HOXB9
gene id: 9646:HOXB9
uniprot id: D2H571
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9646:ATP6V0B
gene id: 9646:ATP6V0B
uniprot id: G1L2P8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9646:NGRN
gene id: 9646:NGRN
uniprot id: D2HCY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

9646:SCN1B
gene id: 9646:SCN1B
uniprot id: G1L002
names: Subcellular Location Annotation
messages: Membrane

9646:CCNA2
gene id: 9646:CCNA2
uniprot id: D2HN58
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9646:CREB1
gene id: 9646:CREB1
uniprot id: D2H8G8
names: Subcellular Location Annotation
messages: Nucleus

9646:ADTRP
gene id: 9646:ADTRP
uniprot id: G1L7H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9646:GNL2
gene id: 9646:GNL2
uniprot id: G1L2J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

9646:ZSCAN26
gene id: 9646:ZSCAN26
uniprot id: A0A7N5P589
names: Subcellular Location Annotation
messages: Nucleus

9646:DMAP1
gene id: 9646:DMAP1
uniprot id: G1M614
names: Subcellular Location Annotation
messages: Nucleus

9646:RPL36
gene id: 9646:RPL36
uniprot id: F2X284
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

9646:TPPP3
gene id: 9646:TPPP3
uniprot id: D2H9E4
names: Similarity
messages: Belongs to the TPPP family.

9646:HSPB1
gene id: 9646:HSPB1
uniprot id: G8A3I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9646:FBP2
gene id: 9646:FBP2
uniprot id: G1LYB9
names: Similarity
messages: Belongs to the FBPase class 1 family.

9646:WIF1
gene id: 9646:WIF1
uniprot id: D2HDL2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:KRI1
gene id: 9646:KRI1
uniprot id: G1LY39
names: Similarity
messages: Belongs to the KRI1 family.

9646:DOLK
gene id: 9646:DOLK
uniprot id: D2H154
names: Similarity
messages: Belongs to the polyprenol kinase family.

9646:NDUFB8
gene id: 9646:NDUFB8
uniprot id: G1LJA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9646:DHFR
gene id: 9646:DHFR
uniprot id: G1MB80
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

9646:SYT17
gene id: 9646:SYT17
uniprot id: A0A7N5P8E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

9646:C8A
gene id: 9646:C8A
uniprot id: G1LBN3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:XKRX
gene id: 9646:XKRX
uniprot id: G1LRB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9646:GCK
gene id: 9646:GCK
uniprot id: A0A7N5JAA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9646:LOC100468655
gene id: 9646:LOC100468655
uniprot id: A0A7N5KE34
uniprot id: A0A7N5KRG0
names: Function
names: Similarity
messages: Belongs to the CMP-Neu5Ac hydroxylase family.
messages: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.

9646:DCP2
gene id: 9646:DCP2
uniprot id: G1M1Q3
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9646:GJB1
gene id: 9646:GJB1
uniprot id: D2I1L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9646:RRAGB
gene id: 9646:RRAGB
uniprot id: D2I2Z2
uniprot id: G1M2R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9646:TMEM199
gene id: 9646:TMEM199
uniprot id: D2GU40
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:UBE2B
gene id: 9646:UBE2B
uniprot id: G1MHK7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9646:GSX1
gene id: 9646:GSX1
uniprot id: D2HWR5
names: Subcellular Location Annotation
messages: Nucleus

9646:ZSCAN20
gene id: 9646:ZSCAN20
uniprot id: D2HI41
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9646:DGUOK
gene id: 9646:DGUOK
uniprot id: G1MG75
names: Similarity
messages: Belongs to the DCK/DGK family.

9646:CKAP2L
gene id: 9646:CKAP2L
uniprot id: G1LW65
names: Similarity
messages: Belongs to the CKAP2 family.

9646:DCTN2
gene id: 9646:DCTN2
uniprot id: A0A7N5JKN4
uniprot id: G1LEL0
names: Similarity
messages: Belongs to the dynactin subunit 2 family.

9646:HAO2
gene id: 9646:HAO2
uniprot id: G1MH58
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9646:TMCO5A
gene id: 9646:TMCO5A
uniprot id: G1LP10
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100468099
gene id: 9646:LOC100468099
uniprot id: G1MJN4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:HOXC5
gene id: 9646:HOXC5
uniprot id: D2HM47
uniprot id: G1L1G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9646:FBLN5
gene id: 9646:FBLN5
uniprot id: A0A7N5KNP1
uniprot id: G1M8Q7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:SLC8A3
gene id: 9646:SLC8A3
uniprot id: A0A7N5KAA0
uniprot id: G1M7U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9646:ART5
gene id: 9646:ART5
uniprot id: G1LWS0
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9646:POLL
gene id: 9646:POLL
uniprot id: A0A7N5JP00
uniprot id: G1MGY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9646:HOOK2
gene id: 9646:HOOK2
uniprot id: A0A7N5JH74
uniprot id: G1M0S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9646:NIPBL
gene id: 9646:NIPBL
uniprot id: A0A7N5K622
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9646:IL26
gene id: 9646:IL26
uniprot id: D2H945
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9646:LOC100469796
gene id: 9646:LOC100469796
uniprot id: A0A7N5K081
uniprot id: G1LAK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FXYD family.
messages: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
messages: Membrane
messages: Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

9646:NHEJ1
gene id: 9646:NHEJ1
uniprot id: G1L712
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

9646:EBF2
gene id: 9646:EBF2
uniprot id: G1L0F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9646:LOC100480936
gene id: 9646:LOC100480936
uniprot id: G1M8F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9646:RAD18
gene id: 9646:RAD18
uniprot id: G1M127
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9646:SLC66A3
gene id: 9646:SLC66A3
uniprot id: D2HH97
names: Subcellular Location Annotation
messages: Membrane

9646:VPS35
gene id: 9646:VPS35
uniprot id: G1MJ51
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9646:SLC2A3
gene id: 9646:SLC2A3
uniprot id: G1MF91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane

9646:ARHGAP26
gene id: 9646:ARHGAP26
uniprot id: A0A7N5JKZ3
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9646:E2F8
gene id: 9646:E2F8
uniprot id: G1MHY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9646:TIMM9
gene id: 9646:TIMM9
uniprot id: D2GVR2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9646:DDAH2
gene id: 9646:DDAH2
uniprot id: D2I498
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9646:NR1D1
gene id: 9646:NR1D1
uniprot id: G1LME6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9646:FABP1
gene id: 9646:FABP1
uniprot id: G1LU22
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9646:LOC100474142
gene id: 9646:LOC100474142
uniprot id: D2HJC9
names: Subcellular Location Annotation
messages: Membrane

9646:SUPT4H1
gene id: 9646:SUPT4H1
uniprot id: G1LYX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9646:PNPO
gene id: 9646:PNPO
uniprot id: D2H555
uniprot id: G1LDU2
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

9646:CDK20
gene id: 9646:CDK20
uniprot id: G1L994
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: cilium

9646:NSUN7
gene id: 9646:NSUN7
uniprot id: D2HV52
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:CCDC65
gene id: 9646:CCDC65
uniprot id: G1LKJ8
names: Subcellular Location Annotation
messages: flagellum axoneme

9646:FAM135A
gene id: 9646:FAM135A
uniprot id: A0A7N5K457
names: Similarity
messages: Belongs to the FAM135 family.

9646:LOC100481237
gene id: 9646:LOC100481237
uniprot id: D2H3D3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9646:EXTL3
gene id: 9646:EXTL3
uniprot id: D2HAJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:NUP107
gene id: 9646:NUP107
uniprot id: G1LPV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

9646:EIF3I
gene id: 9646:EIF3I
uniprot id: G1LMI2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9646:PLPP5
gene id: 9646:PLPP5
uniprot id: G1LXN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9646:NSRP1
gene id: 9646:NSRP1
uniprot id: A0A7N5KN26
names: Similarity
messages: Belongs to the NSRP1 family.

9646:ATP6V1B1
gene id: 9646:ATP6V1B1
uniprot id: D2H0D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9646:SGSH
gene id: 9646:SGSH
uniprot id: G1M9N9
names: Similarity
messages: Belongs to the sulfatase family.

9646:FTMT
gene id: 9646:FTMT
uniprot id: D2HAR2
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9646:POLR2F
gene id: 9646:POLR2F
uniprot id: G1LUW9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9646:CLCN1
gene id: 9646:CLCN1
uniprot id: G1LJD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9646:GAD1
gene id: 9646:GAD1
uniprot id: A0A7N5JG49
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9646:LOC100470383
gene id: 9646:LOC100470383
uniprot id: D2HTW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9646:WDR55
gene id: 9646:WDR55
uniprot id: D2GUN6
names: Function
names: Similarity
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.

9646:FOXF1
gene id: 9646:FOXF1
uniprot id: G1MIW9
names: Subcellular Location Annotation
messages: Nucleus

9646:GPBP1
gene id: 9646:GPBP1
uniprot id: G1LAJ8
uniprot id: G1LAK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9646:AQP1
gene id: 9646:AQP1
uniprot id: D2HBL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9646:STX7
gene id: 9646:STX7
uniprot id: G1LVM7
names: Similarity
messages: Belongs to the syntaxin family.

9646:SNX11
gene id: 9646:SNX11
uniprot id: A0A7N5P944
uniprot id: D2H561
uniprot id: G1LE53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9646:ACOT8
gene id: 9646:ACOT8
uniprot id: G1M1P2
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9646:PTS
gene id: 9646:PTS
uniprot id: G1LBC1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9646:SLC25A16
gene id: 9646:SLC25A16
uniprot id: G1MI54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:SOX14
gene id: 9646:SOX14
uniprot id: D2HLV9
names: Subcellular Location Annotation
messages: Nucleus

9646:HEXD
gene id: 9646:HEXD
uniprot id: G1L2Z5
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

9646:SPRING1
gene id: 9646:SPRING1
uniprot id: D2HFB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

9646:ILK
gene id: 9646:ILK
uniprot id: D2HR59
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9646:MDK
gene id: 9646:MDK
uniprot id: G1LJK9
names: Similarity
messages: Belongs to the pleiotrophin family.

9646:ETFDH
gene id: 9646:ETFDH
uniprot id: A0A7N5P9U8
uniprot id: G1L6D0
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9646:ZNF706
gene id: 9646:ZNF706
uniprot id: D2GY29
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:TMEM251
gene id: 9646:TMEM251
uniprot id: G1M4T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LYSET family.
messages: Membrane

9646:HEXIM1
gene id: 9646:HEXIM1
uniprot id: D2HCX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9646:LYRM1
gene id: 9646:LYRM1
uniprot id: D2HXQ6
names: Similarity
messages: Belongs to the complex I LYR family.

9646:LOC100477929
gene id: 9646:LOC100477929
uniprot id: D2HVS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9646:MKS1
gene id: 9646:MKS1
uniprot id: D2I2K1
names: Subcellular Location Annotation
messages: cilium basal body

9646:AWAT2
gene id: 9646:AWAT2
uniprot id: G1LR39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9646:CPLX1
gene id: 9646:CPLX1
uniprot id: G1MEB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9646:FAM53A
gene id: 9646:FAM53A
uniprot id: A0A7N5KEI6
names: Similarity
messages: Belongs to the FAM53 family.

9646:CA11
gene id: 9646:CA11
uniprot id: G1M8F5
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9646:RFWD3
gene id: 9646:RFWD3
uniprot id: D2HWM5
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.
messages: Interacts with MDM2 and p53/TP53. Binds to the RPA complex via direct interaction with RPA2. Interacts with RAD51.
messages: Nucleus
messages: PML body
messages: Phosphorylated at Ser-46 and Ser-63 upon DNA damage by ATM or ATR. ATM phosphorylation occurs at early times upon DNA damage, while ATR is the major kinase at later times. Phosphorylation by ATM and ATR is required to stabilize p53/TP53. Part of the phosphorylation depends upon RPA2 presence.
messages: The coiled coil domain may be involved in RPA2-binding.

9646:TMEM41B
gene id: 9646:TMEM41B
uniprot id: D2H3H9
uniprot id: G1LBD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9646:LOC100483970
gene id: 9646:LOC100483970
uniprot id: A0A7N5K740
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:ATP6V1D
gene id: 9646:ATP6V1D
uniprot id: G1LNQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

9646:SEC61A1
gene id: 9646:SEC61A1
uniprot id: A0A7N5K9L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:POLR2K
gene id: 9646:POLR2K
uniprot id: A0A7N5JDZ3
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9646:MPEG1
gene id: 9646:MPEG1
uniprot id: D2HZE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9646:PTH
gene id: 9646:PTH
uniprot id: D2HU58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
messages: Secreted

9646:BRS3
gene id: 9646:BRS3
uniprot id: G1L874
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9646:LIX1
gene id: 9646:LIX1
uniprot id: D2HCJ9
names: Similarity
messages: Belongs to the LIX1 family.

9646:LOC100470307
gene id: 9646:LOC100470307
uniprot id: D2I2B7
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9646:SLC1A7
gene id: 9646:SLC1A7
uniprot id: D2H2E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9646:KRT8
gene id: 9646:KRT8
uniprot id: D2HLN8
names: Similarity
messages: Belongs to the intermediate filament family.

9646:LAMA3
gene id: 9646:LAMA3
uniprot id: A0A7N5KCN7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9646:MRTO4
gene id: 9646:MRTO4
uniprot id: G1L8I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9646:TBC1D24
gene id: 9646:TBC1D24
uniprot id: D2HV77
uniprot id: G1MI01
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse

9646:IL3RA
gene id: 9646:IL3RA
uniprot id: G1LG96
names: Subcellular Location Annotation
messages: Membrane

9646:NUDT21
gene id: 9646:NUDT21
uniprot id: G1MDZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

9646:DDX27
gene id: 9646:DDX27
uniprot id: G1M4Y6
names: Similarity
messages: Belongs to the DEAD box helicase family.

9646:BMS1
gene id: 9646:BMS1
uniprot id: G1MEP1
names: Subcellular Location Annotation
messages: nucleolus

9646:ZER1
gene id: 9646:ZER1
uniprot id: G1MBB1
names: Similarity
messages: Belongs to the zyg-11 family.

9646:RPS3A
gene id: 9646:RPS3A
uniprot id: F2X201
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

9646:TMEM87A
gene id: 9646:TMEM87A
uniprot id: G1MCF8
names: Subcellular Location Annotation
messages: Membrane

9646:KEG54 p02
gene id: 9646:KEG54_p02
uniprot id: A5JFK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9646:MRPL37
gene id: 9646:MRPL37
uniprot id: G1LT82
names: Subcellular Location Annotation
messages: Mitochondrion

9646:YWHAG
gene id: 9646:YWHAG
uniprot id: D2HM80
names: Similarity
messages: Belongs to the 14-3-3 family.

9646:FAM163A
gene id: 9646:FAM163A
uniprot id: D2H3M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9646:SLC7A8
gene id: 9646:SLC7A8
uniprot id: A0A7N5JCZ1
names: Subcellular Location Annotation
messages: Membrane

9646:CTH
gene id: 9646:CTH
uniprot id: G1KZI0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

9646:TAP2
gene id: 9646:TAP2
uniprot id: A0A7N5KIX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

9646:TUBD1
gene id: 9646:TUBD1
uniprot id: D2HLU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9646:TEK
gene id: 9646:TEK
uniprot id: G1L4T4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:TRMO
gene id: 9646:TRMO
uniprot id: G1LDL3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

9646:LYPLAL1
gene id: 9646:LYPLAL1
uniprot id: G1LWH5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9646:EXOG
gene id: 9646:EXOG
uniprot id: A0A7N5KC43
uniprot id: G1MH57
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9646:NSUN4
gene id: 9646:NSUN4
uniprot id: G1M5U1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9646:PSMB7
gene id: 9646:PSMB7
uniprot id: D2HDG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9646:HACD3
gene id: 9646:HACD3
uniprot id: D2GYT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:POLR1B
gene id: 9646:POLR1B
uniprot id: D2HUR1
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

9646:EXOC3L1
gene id: 9646:EXOC3L1
uniprot id: G1MFW1
names: Similarity
messages: Belongs to the SEC6 family.

9646:TAF5
gene id: 9646:TAF5
uniprot id: D2GXX8
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9646:MARK2
gene id: 9646:MARK2
uniprot id: A0A7N5KA23
uniprot id: G1MIH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9646:BICD1
gene id: 9646:BICD1
uniprot id: A0A7N5JVD2
uniprot id: A0A7N5P747
uniprot id: G1LQZ6
names: Similarity
messages: Belongs to the BicD family.

9646:LPCAT3
gene id: 9646:LPCAT3
uniprot id: G1M560
names: Subcellular Location Annotation
messages: Membrane

9646:SLC35A1
gene id: 9646:SLC35A1
uniprot id: G1LCQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9646:RPA4
gene id: 9646:RPA4
uniprot id: D2HT85
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

9646:SLC34A2
gene id: 9646:SLC34A2
uniprot id: D2HQ32
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9646:ADAM20
gene id: 9646:ADAM20
uniprot id: G1MND1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:LOC100472112
gene id: 9646:LOC100472112
uniprot id: D2HGK1
names: Similarity
messages: Belongs to the cytochrome b5 family.

9646:TPM3
gene id: 9646:TPM3
uniprot id: A0A7N5JMT9
uniprot id: A0A7N5K2R8
uniprot id: D2HJP4
uniprot id: G1LZH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9646:CCN1
gene id: 9646:CCN1
uniprot id: D2HBY1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:FGF1
gene id: 9646:FGF1
uniprot id: D2GUK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9646:LARS1
gene id: 9646:LARS1
uniprot id: G1MGU6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9646:MEIS2
gene id: 9646:MEIS2
uniprot id: A0A7N5KRA6
uniprot id: G1LQR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9646:CCDC86
gene id: 9646:CCDC86
uniprot id: D2I0J7
names: Subcellular Location Annotation
messages: Nucleus

9646:CTNNBIP1
gene id: 9646:CTNNBIP1
uniprot id: G1LBW4
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9646:NTF4
gene id: 9646:NTF4
uniprot id: D2H7X3
names: Similarity
messages: Belongs to the NGF-beta family.

9646:ATP1A3
gene id: 9646:ATP1A3
uniprot id: G1LDE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9646:LOC100475026
gene id: 9646:LOC100475026
uniprot id: D2I695
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ISCA2
gene id: 9646:ISCA2
uniprot id: G1MIX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9646:CENPI
gene id: 9646:CENPI
uniprot id: D2I0B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-I/CTF3 family.
messages: Nucleus
messages: centromere

9646:PHC3
gene id: 9646:PHC3
uniprot id: A0A7N5JM00
uniprot id: G1LDC6
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100465694
gene id: 9646:LOC100465694
uniprot id: D2HWJ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:SPTBN1
gene id: 9646:SPTBN1
uniprot id: G1LCP4
uniprot id: G1LCQ9
names: Similarity
messages: Belongs to the spectrin family.

9646:NEDD9
gene id: 9646:NEDD9
uniprot id: G1L7H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9646:DPY30
gene id: 9646:DPY30
uniprot id: G1LMF2
names: Similarity
messages: Belongs to the dpy-30 family.

9646:STON2
gene id: 9646:STON2
uniprot id: A0A7N5P9P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: synaptosome

9646:SRPRA
gene id: 9646:SRPRA
uniprot id: D2HV07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:CCN5
gene id: 9646:CCN5
uniprot id: G1LBL0
names: Similarity
messages: Belongs to the CCN family.

9646:SERPINB13
gene id: 9646:SERPINB13
uniprot id: D2H6Z9
names: Similarity
messages: Belongs to the serpin family.

9646:AGRP
gene id: 9646:AGRP
uniprot id: D2H9E8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:SNRPA
gene id: 9646:SNRPA
uniprot id: D2HMU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM U1 A/B'' family.
messages: Nucleus

9646:VPS26A
gene id: 9646:VPS26A
uniprot id: A0A7N5K7U3
names: Similarity
messages: Belongs to the VPS26 family.

9646:HMBOX1
gene id: 9646:HMBOX1
uniprot id: A0A7N5JJ17
names: Subcellular Location Annotation
messages: Nucleus

9646:UBAP2L
gene id: 9646:UBAP2L
uniprot id: A0A7N5K4M2
names: Subcellular Location Annotation
messages: Cytoplasm

9646:CXCR5
gene id: 9646:CXCR5
uniprot id: G1KZK8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:MSRB3
gene id: 9646:MSRB3
uniprot id: A0A7N5K7V9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9646:GLB1
gene id: 9646:GLB1
uniprot id: A0A7N5K226
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9646:RHBDL2
gene id: 9646:RHBDL2
uniprot id: D2HXG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9646:SLAIN2
gene id: 9646:SLAIN2
uniprot id: G1L8L6
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9646:CZIB
gene id: 9646:CZIB
uniprot id: G1LSL9
names: Similarity
messages: Belongs to the UPF0587 family.

9646:TIMP3
gene id: 9646:TIMP3
uniprot id: D2HHA6
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9646:NUP93
gene id: 9646:NUP93
uniprot id: A0A7N5KEU7
uniprot id: D2GTW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9646:UBE4B
gene id: 9646:UBE4B
uniprot id: A0A7N5J9L3
uniprot id: G1LC99
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

9646:SLC35B2
gene id: 9646:SLC35B2
uniprot id: A0A7N5JIH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9646:MNAT1
gene id: 9646:MNAT1
uniprot id: D2GVS6
names: Subcellular Location Annotation
messages: Nucleus

9646:SLC7A1
gene id: 9646:SLC7A1
uniprot id: D2H021
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9646:SEMA3G
gene id: 9646:SEMA3G
uniprot id: G1LQJ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:GJA5
gene id: 9646:GJA5
uniprot id: D2HQ38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9646:SLC25A45
gene id: 9646:SLC25A45
uniprot id: A0A7N5JZ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:LOC100468877
gene id: 9646:LOC100468877
uniprot id: D2HZC3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ABCG5
gene id: 9646:ABCG5
uniprot id: D2GU92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9646:GNG7
gene id: 9646:GNG7
uniprot id: D2HTM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9646:LTN1
gene id: 9646:LTN1
uniprot id: G1LNS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

9646:CFAP206
gene id: 9646:CFAP206
uniprot id: D2HSL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme

9646:IL2
gene id: 9646:IL2
uniprot id: H2DL90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9646:DDRGK1
gene id: 9646:DDRGK1
uniprot id: G1LX14
names: Similarity
messages: Belongs to the DDRGK1 family.

9646:SMAD2
gene id: 9646:SMAD2
uniprot id: D2H8K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9646:DIS3
gene id: 9646:DIS3
uniprot id: A0A7N5JEU4
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9646:HEBP1
gene id: 9646:HEBP1
uniprot id: G1LW27
names: Similarity
messages: Belongs to the HEBP family.

9646:EDEM3
gene id: 9646:EDEM3
uniprot id: D2HFM3
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9646:SOAT1
gene id: 9646:SOAT1
uniprot id: G1M7X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:NSMCE1
gene id: 9646:NSMCE1
uniprot id: G1LBK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9646:SGSM2
gene id: 9646:SGSM2
uniprot id: G1LM18
names: Similarity
messages: Belongs to the RUTBC family.

9646:MYF6
gene id: 9646:MYF6
uniprot id: D2H510
names: Subcellular Location Annotation
messages: Nucleus

9646:ACRBP
gene id: 9646:ACRBP
uniprot id: D2HJ17
names: Subcellular Location Annotation
messages: acrosome

9646:LOXL3
gene id: 9646:LOXL3
uniprot id: D2HH53
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9646:PRIMPOL
gene id: 9646:PRIMPOL
uniprot id: D2GY65
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9646:FGD4
gene id: 9646:FGD4
uniprot id: A0A7N5KGR8
names: Subcellular Location Annotation
messages: cytoskeleton

9646:PPP4R3A
gene id: 9646:PPP4R3A
uniprot id: G1L480
names: Similarity
messages: Belongs to the SMEK family.

9646:IL19
gene id: 9646:IL19
uniprot id: A0A7N5JCE3
uniprot id: G1MGI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9646:ELAVL1
gene id: 9646:ELAVL1
uniprot id: D2HI97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm

9646:CDH5
gene id: 9646:CDH5
uniprot id: D2H9B3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9646:UBA2
gene id: 9646:UBA2
uniprot id: D2HRQ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Nucleus

9646:PHYHIP
gene id: 9646:PHYHIP
uniprot id: D2H046
names: Similarity
messages: Belongs to the PHYHIP family.

9646:HSD17B13
gene id: 9646:HSD17B13
uniprot id: G1L9A8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:LECT2
gene id: 9646:LECT2
uniprot id: G1MHS8
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9646:ICOS
gene id: 9646:ICOS
uniprot id: A0A7N5JDD1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9646:TGIF1
gene id: 9646:TGIF1
uniprot id: G1M1X3
names: Subcellular Location Annotation
messages: Nucleus

9646:OSBPL6
gene id: 9646:OSBPL6
uniprot id: G1L214
names: Similarity
messages: Belongs to the OSBP family.

9646:DCK
gene id: 9646:DCK
uniprot id: G1LH94
names: Similarity
messages: Belongs to the DCK/DGK family.

9646:LOC100465045
gene id: 9646:LOC100465045
uniprot id: D2GV84
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:NTRK2
gene id: 9646:NTRK2
uniprot id: A0A7N5K4R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9646:EEF1AKMT1
gene id: 9646:EEF1AKMT1
uniprot id: G1M856
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

9646:C5H15orf65
gene id: 9646:C5H15orf65
uniprot id: A0A7N5KAD0
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9646:LOC100472805
gene id: 9646:LOC100472805
uniprot id: A0A7N5K4H0
uniprot id: A0A7N5KG27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9646:KCNA10
gene id: 9646:KCNA10
uniprot id: D2HZL8
names: Subcellular Location Annotation
messages: Membrane

9646:CLIC2
gene id: 9646:CLIC2
uniprot id: G1LR82
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9646:CCND3
gene id: 9646:CCND3
uniprot id: D2GZE8
names: Similarity
messages: Belongs to the cyclin family.

9646:PNKD
gene id: 9646:PNKD
uniprot id: G1L8N7
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9646:TPPP
gene id: 9646:TPPP
uniprot id: D2HVI1
names: Similarity
messages: Belongs to the TPPP family.

9646:CNIH1
gene id: 9646:CNIH1
uniprot id: A0A7N5KGJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9646:LOC100481641
gene id: 9646:LOC100481641
uniprot id: D2I509
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:DISP3
gene id: 9646:DISP3
uniprot id: D2HKB1
names: Subcellular Location Annotation
messages: Membrane

9646:MAP2
gene id: 9646:MAP2
uniprot id: A0A7N5JBJ7
names: Subcellular Location Annotation
messages: cytoskeleton

9646:CLCA2
gene id: 9646:CLCA2
uniprot id: D2HBX7
names: Similarity
messages: Belongs to the CLCR family.

9646:LOC100468789
gene id: 9646:LOC100468789
uniprot id: G1M0K6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9646:TMED5
gene id: 9646:TMED5
uniprot id: D2H826
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9646:LOC100465298
gene id: 9646:LOC100465298
uniprot id: D2HTX3
names: Similarity
messages: Belongs to the Bcl-2 family.

9646:MTCP1
gene id: 9646:MTCP1
uniprot id: A0A7N5JC46
names: Similarity
messages: Belongs to the TCL1 family.

9646:NDUFB4
gene id: 9646:NDUFB4
uniprot id: A0A7N5KEF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9646:ATP6V0A1
gene id: 9646:ATP6V0A1
uniprot id: D2HIT6
uniprot id: G1LIT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9646:PPP4C
gene id: 9646:PPP4C
uniprot id: D2HX48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9646:GNPNAT1
gene id: 9646:GNPNAT1
uniprot id: D2I275
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9646:NUP85
gene id: 9646:NUP85
uniprot id: G1LRL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9646:CA14
gene id: 9646:CA14
uniprot id: A0A7N5JRI4
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9646:AGT
gene id: 9646:AGT
uniprot id: G1LT19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

9646:TSN
gene id: 9646:TSN
uniprot id: G1LEL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9646:LOC100470899
gene id: 9646:LOC100470899
uniprot id: D2I1T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ZDHHC9
gene id: 9646:ZDHHC9
uniprot id: G1M953
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9646:LIG4
gene id: 9646:LIG4
uniprot id: D2H2R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9646:RPS19BP1
gene id: 9646:RPS19BP1
uniprot id: D2GZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: nucleolus

9646:ENPP3
gene id: 9646:ENPP3
uniprot id: G1LVA2
names: Subcellular Location Annotation
messages: Secreted

9646:PSMD12
gene id: 9646:PSMD12
uniprot id: A0A7N5JFP7
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

9646:MRRF
gene id: 9646:MRRF
uniprot id: G1L1P2
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9646:B3GALT4
gene id: 9646:B3GALT4
uniprot id: D2GZ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:CCK
gene id: 9646:CCK
uniprot id: D2HN41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

9646:EXOC1
gene id: 9646:EXOC1
uniprot id: A0A7N5KCD9
uniprot id: A0A7N5KRD5
uniprot id: D2H8I0
uniprot id: G1LNU1
names: Similarity
messages: Belongs to the SEC3 family.

9646:SLC18A3
gene id: 9646:SLC18A3
uniprot id: D2HWL3
names: Subcellular Location Annotation
messages: Membrane

9646:UBA7
gene id: 9646:UBA7
uniprot id: G1M0R6
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9646:TRMT1L
gene id: 9646:TRMT1L
uniprot id: D2HFM6
uniprot id: G1M4N2
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

9646:ALG8
gene id: 9646:ALG8
uniprot id: D2H3T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:L3MBTL3
gene id: 9646:L3MBTL3
uniprot id: D2HLX1
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100464584
gene id: 9646:LOC100464584
uniprot id: G1MKN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CAMK2D
gene id: 9646:CAMK2D
uniprot id: A0A7N5P4S6
uniprot id: G1LRN5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9646:VIP
gene id: 9646:VIP
uniprot id: G1LWI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9646:RNF31
gene id: 9646:RNF31
uniprot id: D2HG54
uniprot id: G1MD78
names: Similarity
messages: Belongs to the RBR family.

9646:PSMB6
gene id: 9646:PSMB6
uniprot id: G1MCA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9646:RPL23
gene id: 9646:RPL23
uniprot id: F2X264
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.

9646:MAPK6
gene id: 9646:MAPK6
uniprot id: D2HN70
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9646:OLFML3
gene id: 9646:OLFML3
uniprot id: G1L907
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:HSPB8
gene id: 9646:HSPB8
uniprot id: D2HCN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9646:CASP14
gene id: 9646:CASP14
uniprot id: G1L6V2
names: Similarity
messages: Belongs to the peptidase C14A family.

9646:UBL3
gene id: 9646:UBL3
uniprot id: G1LQM0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:PHACTR4
gene id: 9646:PHACTR4
uniprot id: A0A7N5KMV8
uniprot id: G1LXV4
uniprot id: G1LXW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

9646:RPS15
gene id: 9646:RPS15
uniprot id: B5KKL3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Component of the small ribosomal subunit.

9646:NUBP2
gene id: 9646:NUBP2
uniprot id: G1LP85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9646:RPS17
gene id: 9646:RPS17
uniprot id: D3YBZ9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9646:CENPT
gene id: 9646:CENPT
uniprot id: G1MGP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus
messages: kinetochore

9646:IP6K2
gene id: 9646:IP6K2
uniprot id: G1L0Z4
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9646:DKK1
gene id: 9646:DKK1
uniprot id: D2HH81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9646:DNASE1L1
gene id: 9646:DNASE1L1
uniprot id: A0A7N5K9T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Nucleus envelope
messages: Zymogen granule

9646:ATP6V1E1
gene id: 9646:ATP6V1E1
uniprot id: G1MGJ9
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9646:RAG2
gene id: 9646:RAG2
uniprot id: D2HV50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9646:LOC100471425
gene id: 9646:LOC100471425
uniprot id: G1LLL8
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9646:LOC100467890
gene id: 9646:LOC100467890
uniprot id: D2I7P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC100484936
gene id: 9646:LOC100484936
uniprot id: A0A7N5P5V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9646:SNAP25
gene id: 9646:SNAP25
uniprot id: A0A7N5JME4
uniprot id: G1LAD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9646:ZDHHC22
gene id: 9646:ZDHHC22
uniprot id: G1MJ71
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9646:GALNT5
gene id: 9646:GALNT5
uniprot id: G1M739
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9646:CSF2RB
gene id: 9646:CSF2RB
uniprot id: G1LTB8
names: Subcellular Location Annotation
messages: Membrane

9646:POLR3C
gene id: 9646:POLR3C
uniprot id: A0A7N5KME8
uniprot id: G1MGP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9646:CTNND1
gene id: 9646:CTNND1
uniprot id: A0A7N5KM95
names: Similarity
messages: Belongs to the beta-catenin family.

9646:LOC100473409
gene id: 9646:LOC100473409
uniprot id: D2I6L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC100480798
gene id: 9646:LOC100480798
uniprot id: D2I7M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:DTD2
gene id: 9646:DTD2
uniprot id: D2H9M3
names: Similarity
messages: Belongs to the DTD family.

9646:MTFR1L
gene id: 9646:MTFR1L
uniprot id: G1LUR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9646:OSBPL8
gene id: 9646:OSBPL8
uniprot id: G1LJ33
uniprot id: G1LJ35
names: Similarity
messages: Belongs to the OSBP family.

9646:TNS4
gene id: 9646:TNS4
uniprot id: D2HR24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9646:SLC28A3
gene id: 9646:SLC28A3
uniprot id: G1LBC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9646:MAP3K7
gene id: 9646:MAP3K7
uniprot id: A0A7N5JGB4
uniprot id: D2HRF5
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9646:LOC100470813
gene id: 9646:LOC100470813
uniprot id: D2I2B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9646:BMP5
gene id: 9646:BMP5
uniprot id: D2HAN3
names: Similarity
messages: Belongs to the TGF-beta family.

9646:RAB39B
gene id: 9646:RAB39B
uniprot id: D2I6G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9646:GYS2
gene id: 9646:GYS2
uniprot id: D2I1F2
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9646:APTX
gene id: 9646:APTX
uniprot id: A0A7N5KGT1
names: Subcellular Location Annotation
messages: nucleolus
messages: nucleoplasm

9646:EMP3
gene id: 9646:EMP3
uniprot id: D2H802
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9646:LOC100476803
gene id: 9646:LOC100476803
uniprot id: G1MKN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:EFNB2
gene id: 9646:EFNB2
uniprot id: G1LC70
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:CCR9
gene id: 9646:CCR9
uniprot id: A0A7N5JVH1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:SLC23A2
gene id: 9646:SLC23A2
uniprot id: A0A7N5JEP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9646:BORCS5
gene id: 9646:BORCS5
uniprot id: A0A7N5JU16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9646:RAB3IL1
gene id: 9646:RAB3IL1
uniprot id: A0A7N5K7B0
names: Similarity
messages: Belongs to the SEC2 family.

9646:TNKS
gene id: 9646:TNKS
uniprot id: G1LHI1
names: Function
names: Similarity
messages: Belongs to the ARTD/PARP family.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9646:IL1R2
gene id: 9646:IL1R2
uniprot id: A0A7N5JIR1
uniprot id: G1M392
names: Subcellular Location Annotation
messages: Cell membrane

9646:TMEM50A
gene id: 9646:TMEM50A
uniprot id: A0A7N5JWR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9646:STAT2
gene id: 9646:STAT2
uniprot id: D2H356
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9646:SMC1A
gene id: 9646:SMC1A
uniprot id: D2HVV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9646:HARBI1
gene id: 9646:HARBI1
uniprot id: D2HHI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9646:NXPE3
gene id: 9646:NXPE3
uniprot id: G1LAJ0
names: Similarity
messages: Belongs to the NXPE family.

9646:HSCB
gene id: 9646:HSCB
uniprot id: A0A7N5JFF1
uniprot id: A0A7N5P846
uniprot id: G1LPD9
names: Similarity
messages: Belongs to the HscB family.

9646:USP1
gene id: 9646:USP1
uniprot id: D2H7G9
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9646:CFB
gene id: 9646:CFB
uniprot id: D2I358
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:ASIC4
gene id: 9646:ASIC4
uniprot id: G1MEM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9646:CCN3
gene id: 9646:CCN3
uniprot id: D2I2V9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:TMEM115
gene id: 9646:TMEM115
uniprot id: D2HES1
names: Subcellular Location Annotation
messages: Membrane

9646:GABRG1
gene id: 9646:GABRG1
uniprot id: A0A7N5KNE9
uniprot id: G1MC80
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:LOC100476647
gene id: 9646:LOC100476647
uniprot id: G1M580
names: Similarity
messages: Belongs to the GroES chaperonin family.

9646:PINLYP
gene id: 9646:PINLYP
uniprot id: G1LCA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNF-like-inhibitor family.
messages: Secreted

9646:TM7SF2
gene id: 9646:TM7SF2
uniprot id: D2H4R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9646:FEZ1
gene id: 9646:FEZ1
uniprot id: A0A7N5KKM0
uniprot id: G1L2B6
names: Similarity
messages: Belongs to the zygin family.

9646:PAQR3
gene id: 9646:PAQR3
uniprot id: D2GUG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9646:PPM1B
gene id: 9646:PPM1B
uniprot id: A0A7N5JBX3
uniprot id: D2GU95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9646:BMPR2
gene id: 9646:BMPR2
uniprot id: G1M3F0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9646:CHMP4C
gene id: 9646:CHMP4C
uniprot id: D2H4W1
names: Similarity
messages: Belongs to the SNF7 family.

9646:MRPL42
gene id: 9646:MRPL42
uniprot id: G1LTC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9646:CASQ2
gene id: 9646:CASQ2
uniprot id: D2HS21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9646:TTC38
gene id: 9646:TTC38
uniprot id: G1L9H6
names: Similarity
messages: Belongs to the TTC38 family.

9646:UPF3B
gene id: 9646:UPF3B
uniprot id: D2HJS9
uniprot id: G1KZX9
names: Similarity
messages: Belongs to the RENT3 family.

9646:TRAF5
gene id: 9646:TRAF5
uniprot id: D2H652
names: Subcellular Location Annotation
messages: Cytoplasm

9646:POLR3F
gene id: 9646:POLR3F
uniprot id: G1LF40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9646:FAM151B
gene id: 9646:FAM151B
uniprot id: G1MB76
names: Similarity
messages: Belongs to the FAM151 family.

9646:ANXA1
gene id: 9646:ANXA1
uniprot id: G1MAP8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9646:METAP1D
gene id: 9646:METAP1D
uniprot id: A0A7N5KF98
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9646:EEF1D
gene id: 9646:EEF1D
uniprot id: D2HIP6
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

9646:PHF10
gene id: 9646:PHF10
uniprot id: A0A7N5JKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

9646:EFNA1
gene id: 9646:EFNA1
uniprot id: D2HJM2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:FDPS
gene id: 9646:FDPS
uniprot id: A0A7N5P1A6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9646:HSPH1
gene id: 9646:HSPH1
uniprot id: D2H013
uniprot id: G1LQF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

9646:CHD9
gene id: 9646:CHD9
uniprot id: A0A7N5KLU4
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9646:PRPF38A
gene id: 9646:PRPF38A
uniprot id: G1LRX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9646:GUCA2A
gene id: 9646:GUCA2A
uniprot id: G1L184
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9646:UCP1
gene id: 9646:UCP1
uniprot id: D2HWA3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

9646:NDUFB3
gene id: 9646:NDUFB3
uniprot id: D2H2Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9646:PARD6A
gene id: 9646:PARD6A
uniprot id: D2H9F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9646:TTC25
gene id: 9646:TTC25
uniprot id: G1LH18
names: Subcellular Location Annotation
messages: cilium axoneme

9646:LRTOMT
gene id: 9646:LRTOMT
uniprot id: G1LWE8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9646:AZIN1
gene id: 9646:AZIN1
uniprot id: G1M879
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9646:ZBED1
gene id: 9646:ZBED1
uniprot id: D2HFI5
names: Subcellular Location Annotation
messages: Nucleus

9646:SMU1
gene id: 9646:SMU1
uniprot id: G1LM04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9646:LOC100480184
gene id: 9646:LOC100480184
uniprot id: D2HK73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:SAMM50
gene id: 9646:SAMM50
uniprot id: A0A7N5KK34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

9646:ACSM3
gene id: 9646:ACSM3
uniprot id: D2HXR0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9646:EBF1
gene id: 9646:EBF1
uniprot id: G1LIN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9646:EDN2
gene id: 9646:EDN2
uniprot id: G1L102
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9646:DDX52
gene id: 9646:DDX52
uniprot id: G1M3J1
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

9646:LOC100484125
gene id: 9646:LOC100484125
uniprot id: G1MPL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9646:LOC100474336
gene id: 9646:LOC100474336
uniprot id: G1MP21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC100469120
gene id: 9646:LOC100469120
uniprot id: A0A7N5P1E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9646:XCR1
gene id: 9646:XCR1
uniprot id: D2GV80
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:TMEM45B
gene id: 9646:TMEM45B
uniprot id: D2GUX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9646:TMEM70
gene id: 9646:TMEM70
uniprot id: G1M2G9
names: Similarity
messages: Belongs to the TMEM70 family.

9646:ALOX5
gene id: 9646:ALOX5
uniprot id: D2HUH1
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:ELOF1
gene id: 9646:ELOF1
uniprot id: D2I6N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9646:EZH1
gene id: 9646:EZH1
uniprot id: A0A7N5KE59
names: Subcellular Location Annotation
messages: Nucleus

9646:XPC
gene id: 9646:XPC
uniprot id: G1LS59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

9646:SELENOS
gene id: 9646:SELENOS
uniprot id: G1LKM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
messages: Membrane

9646:B3GALT5
gene id: 9646:B3GALT5
uniprot id: D2HZR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:SERPINA4
gene id: 9646:SERPINA4
uniprot id: G1LII5
names: Similarity
messages: Belongs to the serpin family.

9646:MTERF4
gene id: 9646:MTERF4
uniprot id: G1ME26
names: Similarity
messages: Belongs to the mTERF family.

9646:GPR182
gene id: 9646:GPR182
uniprot id: D2H369
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:TPD52L1
gene id: 9646:TPD52L1
uniprot id: A0A7N5K7A1
names: Similarity
messages: Belongs to the TPD52 family.

9646:PRDM10
gene id: 9646:PRDM10
uniprot id: G1L6P2
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9646:HAT1
gene id: 9646:HAT1
uniprot id: G1LPG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9646:LOC100481892
gene id: 9646:LOC100481892
uniprot id: D2I658
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:RHOT1
gene id: 9646:RHOT1
uniprot id: A0A7N5JC54
uniprot id: A0A7N5JXF5
uniprot id: A0A7N5P042
uniprot id: G1LG95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9646:TGIF2
gene id: 9646:TGIF2
uniprot id: D2H465
names: Subcellular Location Annotation
messages: Nucleus

9646:INSIG2
gene id: 9646:INSIG2
uniprot id: G1M1N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9646:STAT4
gene id: 9646:STAT4
uniprot id: A0A7N5PAF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9646:NRDC
gene id: 9646:NRDC
uniprot id: G1LRA6
names: Similarity
messages: Belongs to the peptidase M16 family.

9646:L3MBTL2
gene id: 9646:L3MBTL2
uniprot id: G1M634
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

9646:C1H3orf70
gene id: 9646:C1H3orf70
uniprot id: D2H297
names: Similarity
messages: Belongs to the UPF0524 family.

9646:THG1L
gene id: 9646:THG1L
uniprot id: D2GUI2
names: Cofactor
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

9646:DCTPP1
gene id: 9646:DCTPP1
uniprot id: G1LML2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9646:DDX43
gene id: 9646:DDX43
uniprot id: G1LMN7
names: Similarity
messages: Belongs to the DEAD box helicase family.

9646:HDAC6
gene id: 9646:HDAC6
uniprot id: G1M1M5
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.

9646:RIOK1
gene id: 9646:RIOK1
uniprot id: G1MG84
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9646:NAA10
gene id: 9646:NAA10
uniprot id: G1MJH5
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9646:XRCC1
gene id: 9646:XRCC1
uniprot id: D2HNF1
names: Subcellular Location Annotation
messages: Nucleus

9646:KEG54 p09
gene id: 9646:KEG54_p09
uniprot id: A5JFK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9646:LOC100477672
gene id: 9646:LOC100477672
uniprot id: D2HVS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9646:SFR1
gene id: 9646:SFR1
uniprot id: A0A7N5JI35
uniprot id: G1MI37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

9646:DPYSL4
gene id: 9646:DPYSL4
uniprot id: G1LWE1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9646:MMP8
gene id: 9646:MMP8
uniprot id: G1LUC1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9646:DARS2
gene id: 9646:DARS2
uniprot id: A0A7N5JWJ3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

9646:YIF1A
gene id: 9646:YIF1A
uniprot id: G1MFG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9646:SARAF
gene id: 9646:SARAF
uniprot id: A0A7N5JAN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9646:LOC100474694
gene id: 9646:LOC100474694
uniprot id: D2H366
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:SLC20A2
gene id: 9646:SLC20A2
uniprot id: D2H978
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

9646:LMX1B
gene id: 9646:LMX1B
uniprot id: A0A7N5K9U4
names: Subcellular Location Annotation
messages: Nucleus

9646:SEMA4F
gene id: 9646:SEMA4F
uniprot id: A0A7N5JQS7
uniprot id: A0A7N5KLW9
uniprot id: D2HH51
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:CPEB4
gene id: 9646:CPEB4
uniprot id: A0A7N5K4R5
uniprot id: A0A7N5KAC3
uniprot id: A0A7N5P9R6
uniprot id: D2H5F8
names: Similarity
messages: Belongs to the RRM CPEB family.

9646:P2RY4
gene id: 9646:P2RY4
uniprot id: D2H897
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:ATP11C
gene id: 9646:ATP11C
uniprot id: A0A7N5KLC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9646:IK
gene id: 9646:IK
uniprot id: G1LWN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9646:CACNG4
gene id: 9646:CACNG4
uniprot id: D2HQ98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.

9646:MBOAT4
gene id: 9646:MBOAT4
uniprot id: G1L3V3
names: Subcellular Location Annotation
messages: Membrane

9646:UPF2
gene id: 9646:UPF2
uniprot id: D2HRM0
names: Subcellular Location Annotation
messages: Cytoplasm

9646:CORO1A
gene id: 9646:CORO1A
uniprot id: D2HX51
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

9646:SMG6
gene id: 9646:SMG6
uniprot id: G1LM72
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.
messages: Plays a role in nonsense-mediated mRNA decay.
messages: The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.
messages: cytosol
messages: nucleolus
messages: telomere

9646:CAVIN3
gene id: 9646:CAVIN3
uniprot id: D2HR67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9646:PPME1
gene id: 9646:PPME1
uniprot id: G1MFP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Binds PPP2CA and PPP2CB.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

9646:SLC39A14
gene id: 9646:SLC39A14
uniprot id: D2H043
names: Subcellular Location Annotation
messages: Membrane

9646:EIF1
gene id: 9646:EIF1
uniprot id: D2Y399
names: Similarity
messages: Belongs to the SUI1 family.

9646:RAB18
gene id: 9646:RAB18
uniprot id: G1MC16
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9646:LOC100464640
gene id: 9646:LOC100464640
uniprot id: G1LMS4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9646:MYOZ1
gene id: 9646:MYOZ1
uniprot id: G1MEL2
names: Similarity
messages: Belongs to the myozenin family.

9646:TOM1L2
gene id: 9646:TOM1L2
uniprot id: G1LES4
names: Similarity
messages: Belongs to the TOM1 family.

9646:RBKS
gene id: 9646:RBKS
uniprot id: G1L2V0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9646:PPIP5K1
gene id: 9646:PPIP5K1
uniprot id: G1M9Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9646:PLXNA2
gene id: 9646:PLXNA2
uniprot id: G1LNL6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:CDH18
gene id: 9646:CDH18
uniprot id: G1LMB4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9646:SIX2
gene id: 9646:SIX2
uniprot id: D2GUA0
names: Subcellular Location Annotation
messages: Nucleus

9646:RMND1
gene id: 9646:RMND1
uniprot id: G1LX60
names: Similarity
messages: Belongs to the RMD1/sif2 family.

9646:SQLE
gene id: 9646:SQLE
uniprot id: D2HFA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9646:G6PC3
gene id: 9646:G6PC3
uniprot id: D2HCU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9646:LOC100482711
gene id: 9646:LOC100482711
uniprot id: D2HW23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:MAPK9
gene id: 9646:MAPK9
uniprot id: D2HY90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9646:AQP6
gene id: 9646:AQP6
uniprot id: G1L2M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9646:PES1
gene id: 9646:PES1
uniprot id: A0A7N5K9I3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Chromosome
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Sumoylated.
messages: nucleolus
messages: nucleoplasm

9646:IL12RB2
gene id: 9646:IL12RB2
uniprot id: G1LD64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9646:ID3
gene id: 9646:ID3
uniprot id: D2GWC3
names: Subcellular Location Annotation
messages: Nucleus

9646:ORC5
gene id: 9646:ORC5
uniprot id: G1LGP5
names: Subcellular Location Annotation
messages: Nucleus

9646:HCRTR2
gene id: 9646:HCRTR2
uniprot id: D2HL74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:ELF1
gene id: 9646:ELF1
uniprot id: G1LPY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:KDM4C
gene id: 9646:KDM4C
uniprot id: A0A7N5JQL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9646:DNAJC16
gene id: 9646:DNAJC16
uniprot id: D2HH14
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

9646:SNX1
gene id: 9646:SNX1
uniprot id: G1L6V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

9646:SGTB
gene id: 9646:SGTB
uniprot id: G1LXL2
names: Similarity
messages: Belongs to the SGT family.

9646:PTMA
gene id: 9646:PTMA
uniprot id: E7CYG5
names: Similarity
messages: Belongs to the pro/parathymosin family.

9646:ABCD1
gene id: 9646:ABCD1
uniprot id: G1LQ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9646:ENO3
gene id: 9646:ENO3
uniprot id: D2I1K4
uniprot id: G1LIG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9646:BRMS1L
gene id: 9646:BRMS1L
uniprot id: G1MB84
names: Subcellular Location Annotation
messages: Nucleus

9646:IRGC
gene id: 9646:IRGC
uniprot id: D2HNE5
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9646:SLC16A2
gene id: 9646:SLC16A2
uniprot id: G1L7X1
names: Subcellular Location Annotation
messages: Membrane

9646:CD53
gene id: 9646:CD53
uniprot id: G1LVB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9646:LOC100471209
gene id: 9646:LOC100471209
uniprot id: A0A7N5JX83
names: Similarity
messages: Belongs to the cytochrome P450 family.

9646:HOXB1
gene id: 9646:HOXB1
uniprot id: D2H564
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9646:UBAP2
gene id: 9646:UBAP2
uniprot id: G1L0K6
names: Subcellular Location Annotation
messages: Cytoplasm

9646:DYRK4
gene id: 9646:DYRK4
uniprot id: G1MB05
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9646:HNRNPF
gene id: 9646:HNRNPF
uniprot id: D2H6F1
names: Subcellular Location Annotation
messages: nucleoplasm

9646:CHUK
gene id: 9646:CHUK
uniprot id: G1LK22
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:FAM83B
gene id: 9646:FAM83B
uniprot id: G1MGE6
names: Similarity
messages: Belongs to the FAM83 family.

9646:EDNRA
gene id: 9646:EDNRA
uniprot id: D2H5I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9646:LOC100475916
gene id: 9646:LOC100475916
uniprot id: D2HZD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CRY1
gene id: 9646:CRY1
uniprot id: D2HXW9
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

9646:STRA6
gene id: 9646:STRA6
uniprot id: D2HKZ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:TMEM175
gene id: 9646:TMEM175
uniprot id: A0A7N5KBT4
uniprot id: D2HPR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

9646:MPHOSPH10
gene id: 9646:MPHOSPH10
uniprot id: D2HNY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: nucleolus

9646:TPK1
gene id: 9646:TPK1
uniprot id: G1LPU3
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9646:CLDN11
gene id: 9646:CLDN11
uniprot id: D2HFL7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9646:LOC100471070
gene id: 9646:LOC100471070
uniprot id: D2I755
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:SPAM1
gene id: 9646:SPAM1
uniprot id: G1LD44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9646:TPPP2
gene id: 9646:TPPP2
uniprot id: G1LIZ2
names: Similarity
messages: Belongs to the TPPP family.

9646:PLK2
gene id: 9646:PLK2
uniprot id: D2H938
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9646:TMEM129
gene id: 9646:TMEM129
uniprot id: G1MEU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9646:CSE1L
gene id: 9646:CSE1L
uniprot id: G1M575
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9646:ERAL1
gene id: 9646:ERAL1
uniprot id: D2GU20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity).

9646:ALDH6A1
gene id: 9646:ALDH6A1
uniprot id: G1MIX0
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9646:YARS2
gene id: 9646:YARS2
uniprot id: D2H4J9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9646:TMED10
gene id: 9646:TMED10
uniprot id: D2GZX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:DDIT4
gene id: 9646:DDIT4
uniprot id: D2HZB2
names: Similarity
messages: Belongs to the DDIT4 family.

9646:ALDOB
gene id: 9646:ALDOB
uniprot id: D2HV23
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9646:CRYBA4
gene id: 9646:CRYBA4
uniprot id: A0A7N5JYN6
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9646:LPAR2
gene id: 9646:LPAR2
uniprot id: D2GV63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:TMCC2
gene id: 9646:TMCC2
uniprot id: A0A7N5JE38
names: Similarity
messages: Belongs to the TEX28 family.

9646:EPHA1
gene id: 9646:EPHA1
uniprot id: G1LJW7
names: Subcellular Location Annotation
messages: Membrane

9646:HTR2C
gene id: 9646:HTR2C
uniprot id: A0A7N5K7X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:LHFPL6
gene id: 9646:LHFPL6
uniprot id: G1M2I6
names: Subcellular Location Annotation
messages: Membrane

9646:ING3
gene id: 9646:ING3
uniprot id: G1LHC7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9646:RPL18A
gene id: 9646:RPL18A
uniprot id: D7RAF5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9646:LOC100474844
gene id: 9646:LOC100474844
uniprot id: G1MP24
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:NHP2
gene id: 9646:NHP2
uniprot id: D2HNR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9646:SLC39A7
gene id: 9646:SLC39A7
uniprot id: D2GZ05
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100465804
gene id: 9646:LOC100465804
uniprot id: G1MK93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC100472013
gene id: 9646:LOC100472013
uniprot id: D2HDV4
uniprot id: P18970
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

9646:GTF2I
gene id: 9646:GTF2I
uniprot id: G1M9V8
names: Subcellular Location Annotation
messages: Nucleus

9646:PPT1
gene id: 9646:PPT1
uniprot id: A0A7N5JR14
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9646:RPL3
gene id: 9646:RPL3
uniprot id: F2X234
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9646:ABHD6
gene id: 9646:ABHD6
uniprot id: A0A7N5KP14
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

9646:MS4A14
gene id: 9646:MS4A14
uniprot id: G1L0N4
names: Similarity
messages: Belongs to the MS4A family.

9646:GCSH
gene id: 9646:GCSH
uniprot id: D2H7J3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9646:TGM6
gene id: 9646:TGM6
uniprot id: G1LY70
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9646:FRK
gene id: 9646:FRK
uniprot id: D2I0I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9646:LPAR4
gene id: 9646:LPAR4
uniprot id: D2I5D6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:HDHD3
gene id: 9646:HDHD3
uniprot id: D2H2I8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9646:HS2ST1
gene id: 9646:HS2ST1
uniprot id: G1MCN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:FMR1
gene id: 9646:FMR1
uniprot id: A0A7N5K2Z0
uniprot id: A0A7N5K5W9
uniprot id: G1M932
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Stress granule
messages: Synapse
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

9646:CNR1
gene id: 9646:CNR1
uniprot id: D2HSM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: axon

9646:PLP1
gene id: 9646:PLP1
uniprot id: A0A7N5P3Z2
uniprot id: G1LWQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9646:MTRF1L
gene id: 9646:MTRF1L
uniprot id: G1L353
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9646:RPAP1
gene id: 9646:RPAP1
uniprot id: G1ME75
names: Similarity
messages: Belongs to the RPAP1 family.

9646:FAM166C
gene id: 9646:FAM166C
uniprot id: G1L5V4
names: Similarity
messages: Belongs to the CIMIP2 family.

9646:MSTO1
gene id: 9646:MSTO1
uniprot id: D2HZK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Mitochondrion outer membrane

9646:LOC100481664
gene id: 9646:LOC100481664
uniprot id: G1M3M8
names: Similarity
messages: Belongs to the HPF1 family.

9646:ARFGEF1
gene id: 9646:ARFGEF1
uniprot id: D2H429
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9646:XRCC5
gene id: 9646:XRCC5
uniprot id: G1L9U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus

9646:KCNJ10
gene id: 9646:KCNJ10
uniprot id: D2I3Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9646:IL1B
gene id: 9646:IL1B
uniprot id: G1LW44
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9646:DNAAF1
gene id: 9646:DNAAF1
uniprot id: G1LIA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF1 family.
messages: Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli.
messages: cilium

9646:CLK1
gene id: 9646:CLK1
uniprot id: A0A7N5K0W8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:CASK
gene id: 9646:CASK
uniprot id: G1LJM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane

9646:BCAS2
gene id: 9646:BCAS2
uniprot id: D2I0G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

9646:OXCT1
gene id: 9646:OXCT1
uniprot id: G1MBJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9646:ELF2
gene id: 9646:ELF2
uniprot id: A0A7N5JPE3
uniprot id: A0A7N5P6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:GOLPH3L
gene id: 9646:GOLPH3L
uniprot id: A0A7N5JH38
uniprot id: A0A7N5KTC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9646:B9D2
gene id: 9646:B9D2
uniprot id: D2HMT6
names: Subcellular Location Annotation
messages: cilium basal body

9646:KXD1
gene id: 9646:KXD1
uniprot id: D2GV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9646:LOC100478188
gene id: 9646:LOC100478188
uniprot id: G1MKZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CKM
gene id: 9646:CKM
uniprot id: D2HPA6
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9646:LOC100480781
gene id: 9646:LOC100480781
uniprot id: D2I082
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:CA3
gene id: 9646:CA3
uniprot id: G1L714
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9646:SPOCK2
gene id: 9646:SPOCK2
uniprot id: A0A7N5P9C6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:MYO1B
gene id: 9646:MYO1B
uniprot id: A0A7N5JEU6
uniprot id: A0A7N5P711
uniprot id: D2H883
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9646:MELK
gene id: 9646:MELK
uniprot id: A0A7N5K5N7
uniprot id: A0A7N5KRB6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9646:AURKA
gene id: 9646:AURKA
uniprot id: G1LKV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9646:EIF4A1
gene id: 9646:EIF4A1
uniprot id: A0A7N5JJ60
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9646:MPPED2
gene id: 9646:MPPED2
uniprot id: D2HP03
names: Similarity
messages: Belongs to the UPF0046 family.

9646:SLC6A14
gene id: 9646:SLC6A14
uniprot id: G1L4M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9646:NPY1R
gene id: 9646:NPY1R
uniprot id: D2HXK2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:EXT1
gene id: 9646:EXT1
uniprot id: G1L756
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:PNRC2
gene id: 9646:PNRC2
uniprot id: D2GWD3
names: Subcellular Location Annotation
messages: Nucleus

9646:TRPV1
gene id: 9646:TRPV1
uniprot id: D2HZN8
names: Subcellular Location Annotation
messages: Membrane

9646:PRKACA
gene id: 9646:PRKACA
uniprot id: G1M3I9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9646:GNG2
gene id: 9646:GNG2
uniprot id: D2HV45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9646:ZKSCAN2
gene id: 9646:ZKSCAN2
uniprot id: D2I3U4
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9646:TIMM21
gene id: 9646:TIMM21
uniprot id: D2HGK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9646:RNF8
gene id: 9646:RNF8
uniprot id: G1MA53
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9646:PNMT
gene id: 9646:PNMT
uniprot id: G1LTY9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9646:FAM76B
gene id: 9646:FAM76B
uniprot id: D2HT51
names: Similarity
messages: Belongs to the FAM76 family.

9646:RNPS1
gene id: 9646:RNPS1
uniprot id: A0A7N5JBP6
uniprot id: A0A7N5KDU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
messages: Nucleus speckle

9646:LOC105240680
gene id: 9646:LOC105240680
uniprot id: A0A7N5JVK4
uniprot id: A0A7N5K2D1
uniprot id: A0A7N5K8N1
uniprot id: A0A7N5KKX0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:METTL15
gene id: 9646:METTL15
uniprot id: D2HEJ0
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9646:RRN3
gene id: 9646:RRN3
uniprot id: A0A7N5KFY1
names: Similarity
messages: Belongs to the RRN3 family.

9646:MYOG
gene id: 9646:MYOG
uniprot id: D2HSE8
names: Subcellular Location Annotation
messages: Nucleus

9646:FAM118A
gene id: 9646:FAM118A
uniprot id: G1LR18
names: Similarity
messages: Belongs to the FAM118 family.

9646:SLC10A7
gene id: 9646:SLC10A7
uniprot id: A0A7N5P367
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Golgi apparatus membrane

9646:MMACHC
gene id: 9646:MMACHC
uniprot id: D2HC38
names: Similarity
messages: Belongs to the MMACHC family.

9646:SCP2
gene id: 9646:SCP2
uniprot id: G1LSE3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion

9646:STXBP1
gene id: 9646:STXBP1
uniprot id: A0A7N5J998
uniprot id: G1MEC7
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9646:GJB6
gene id: 9646:GJB6
uniprot id: D2I264
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9646:APIP
gene id: 9646:APIP
uniprot id: G1LMZ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9646:HOXC10
gene id: 9646:HOXC10
uniprot id: D2HM44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9646:ABRAXAS1
gene id: 9646:ABRAXAS1
uniprot id: D2GUE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Nucleus

9646:DCLRE1A
gene id: 9646:DCLRE1A
uniprot id: D2GX27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9646:CALB1
gene id: 9646:CALB1
uniprot id: D2HLS9
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

9646:UBE2C
gene id: 9646:UBE2C
uniprot id: G1M1K9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9646:S100A8
gene id: 9646:S100A8
uniprot id: D2HJR9
names: Similarity
messages: Belongs to the S-100 family.

9646:SLC35B3
gene id: 9646:SLC35B3
uniprot id: A0A7N5JNS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9646:GET1
gene id: 9646:GET1
uniprot id: D2HZR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:AASDHPPT
gene id: 9646:AASDHPPT
uniprot id: D2HJ98
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

9646:BTG2
gene id: 9646:BTG2
uniprot id: A0A7N5JZ37
names: Similarity
messages: Belongs to the BTG family.

9646:ALDOC
gene id: 9646:ALDOC
uniprot id: D2GU33
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9646:LOC100475108
gene id: 9646:LOC100475108
uniprot id: D2I5C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:VPS33B
gene id: 9646:VPS33B
uniprot id: D2HCY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9646:TM2D1
gene id: 9646:TM2D1
uniprot id: G1LYZ4
names: Subcellular Location Annotation
messages: Membrane

9646:IL20
gene id: 9646:IL20
uniprot id: A0A7N5KH00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9646:DHRS3
gene id: 9646:DHRS3
uniprot id: G1LJL1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:SLC30A1
gene id: 9646:SLC30A1
uniprot id: D2H655
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9646:ANK3
gene id: 9646:ANK3
uniprot id: A0A7N5KM44
names: Subcellular Location Annotation
messages: Membrane

9646:USP26
gene id: 9646:USP26
uniprot id: D2HAA6
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9646:FAM83G
gene id: 9646:FAM83G
uniprot id: D2HLB1
names: Similarity
messages: Belongs to the FAM83 family.

9646:KEG54 p06
gene id: 9646:KEG54_p06
uniprot id: A5JFK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion membrane

9646:RER1
gene id: 9646:RER1
uniprot id: D2HPP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

9646:LOC100471579
gene id: 9646:LOC100471579
uniprot id: D2GZI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9646:BMP10
gene id: 9646:BMP10
uniprot id: D2I0Z0
names: Similarity
messages: Belongs to the TGF-beta family.

9646:ADH4
gene id: 9646:ADH4
uniprot id: A0A7N5P6U3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9646:COPS8
gene id: 9646:COPS8
uniprot id: D2I3M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9646:CPSF3
gene id: 9646:CPSF3
uniprot id: G1LPK4
names: Subcellular Location Annotation
messages: Nucleus

9646:B3GALT1
gene id: 9646:B3GALT1
uniprot id: D2HZZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:LOC100469936
gene id: 9646:LOC100469936
uniprot id: A0A7N5KS00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC100471322
gene id: 9646:LOC100471322
uniprot id: D2I837
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:B3GNT6
gene id: 9646:B3GNT6
uniprot id: G1MKU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:XK
gene id: 9646:XK
uniprot id: D2GWX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9646:ATP6V1G1
gene id: 9646:ATP6V1G1
uniprot id: D2H2I0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9646:GJB7
gene id: 9646:GJB7
uniprot id: G1MPG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9646:RUVBL2
gene id: 9646:RUVBL2
uniprot id: G1M7J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9646:TNNT3
gene id: 9646:TNNT3
uniprot id: A0A7N5JHF1
uniprot id: A0A7N5P7H2
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9646:HSPA14
gene id: 9646:HSPA14
uniprot id: G1LYF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9646:RPL26
gene id: 9646:RPL26
uniprot id: F2X269
uniprot id: Q2I0I6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Component of the large ribosomal subunit. Interacts with DHX33.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

9646:FAM13C
gene id: 9646:FAM13C
uniprot id: A0A7N5P1Q9
names: Similarity
messages: Belongs to the FAM13 family.

9646:ASF1B
gene id: 9646:ASF1B
uniprot id: D2HFZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9646:EMC4
gene id: 9646:EMC4
uniprot id: D2HRS4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:PSMD4
gene id: 9646:PSMD4
uniprot id: G1L1M2
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9646:MYOF
gene id: 9646:MYOF
uniprot id: A0A7N5JXU4
uniprot id: G1M5W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9646:CDC42
gene id: 9646:CDC42
uniprot id: D2HCB2
uniprot id: G1M7S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

9646:NDUFS1
gene id: 9646:NDUFS1
uniprot id: G1L8K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

9646:LOC100469532
gene id: 9646:LOC100469532
uniprot id: G1MJM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:BANP
gene id: 9646:BANP
uniprot id: A0A7N5KGD6
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9646:LOC100482800
gene id: 9646:LOC100482800
uniprot id: D2I4T6
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:POU4F2
gene id: 9646:POU4F2
uniprot id: D2H3Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9646:VSX2
gene id: 9646:VSX2
uniprot id: D2GZW4
uniprot id: G1MIX3
names: Subcellular Location Annotation
messages: Nucleus

9646:SKAP2
gene id: 9646:SKAP2
uniprot id: G1LH71
names: Similarity
messages: Belongs to the SKAP family.

9646:ARL2
gene id: 9646:ARL2
uniprot id: A0A7N5JY22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9646:GPR18
gene id: 9646:GPR18
uniprot id: G1MP70
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:CALR
gene id: 9646:CALR
uniprot id: D2HG17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9646:LOC100483550
gene id: 9646:LOC100483550
uniprot id: D2I3T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:SLC22A4
gene id: 9646:SLC22A4
uniprot id: A0A7N5KGR7
uniprot id: G1MH36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9646:PIM2
gene id: 9646:PIM2
uniprot id: D2H7M9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

9646:TMTC2
gene id: 9646:TMTC2
uniprot id: G1MEQ3
uniprot id: G1MEQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9646:LOC100470176
gene id: 9646:LOC100470176
uniprot id: G1M528
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9646:PURG
gene id: 9646:PURG
uniprot id: G1MM22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9646:HDAC2
gene id: 9646:HDAC2
uniprot id: G1M3K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9646:CUTA
gene id: 9646:CUTA
uniprot id: G1L3M5
uniprot id: G1L3N1
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9646:SCD
gene id: 9646:SCD
uniprot id: G1LJK5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9646:UNK
gene id: 9646:UNK
uniprot id: A0A7N5JPV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9646:CHGB
gene id: 9646:CHGB
uniprot id: G1LUG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9646:ATXN1L
gene id: 9646:ATXN1L
uniprot id: D2HFW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9646:SLC7A14
gene id: 9646:SLC7A14
uniprot id: D2HFL8
names: Subcellular Location Annotation
messages: Membrane

9646:CDC42EP3
gene id: 9646:CDC42EP3
uniprot id: D2H091
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9646:METTL8
gene id: 9646:METTL8
uniprot id: G1LPX4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9646:CCR7
gene id: 9646:CCR7
uniprot id: G1LNB1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:LOC100471279
gene id: 9646:LOC100471279
uniprot id: D2HK51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:C16H11orf68
gene id: 9646:C16H11orf68
uniprot id: D2H4N7
names: Similarity
messages: Belongs to the UPF0696 family.

9646:SLC30A3
gene id: 9646:SLC30A3
uniprot id: G1L4C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9646:MYH10
gene id: 9646:MYH10
uniprot id: G1L6J5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9646:TMED6
gene id: 9646:TMED6
uniprot id: D2HLI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:PDGFRL
gene id: 9646:PDGFRL
uniprot id: G1M4Z5
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

9646:LOC100464709
gene id: 9646:LOC100464709
uniprot id: D2I6R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9646:CACNG3
gene id: 9646:CACNG3
uniprot id: D2HV93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9646:PGLYRP2
gene id: 9646:PGLYRP2
uniprot id: A0A7N5P7E0
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9646:CLSTN3
gene id: 9646:CLSTN3
uniprot id: G1M4J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

9646:ARRDC2
gene id: 9646:ARRDC2
uniprot id: A0A7N5JPM3
names: Similarity
messages: Belongs to the arrestin family.

9646:DIPK2A
gene id: 9646:DIPK2A
uniprot id: D2H596
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9646:PTP4A3
gene id: 9646:PTP4A3
uniprot id: D2HHH7
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9646:GUCY1B1
gene id: 9646:GUCY1B1
uniprot id: A0A7N5JBE8
uniprot id: G1MAB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9646:PHKG1
gene id: 9646:PHKG1
uniprot id: D2HTC4
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9646:IGF2BP3
gene id: 9646:IGF2BP3
uniprot id: G1L9V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9646:HR
gene id: 9646:HR
uniprot id: D2H051
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9646:LGI1
gene id: 9646:LGI1
uniprot id: G1M530
names: Subcellular Location Annotation
messages: Secreted

9646:RP2
gene id: 9646:RP2
uniprot id: D2HXE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9646:DEF8
gene id: 9646:DEF8
uniprot id: G1L3M3
names: Similarity
messages: Belongs to the DEF8 family.

9646:AASS
gene id: 9646:AASS
uniprot id: D2HAX9
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9646:GATAD2B
gene id: 9646:GATAD2B
uniprot id: D2HJQ3
names: Subcellular Location Annotation
messages: Nucleus

9646:PLPPR4
gene id: 9646:PLPPR4
uniprot id: D2HFF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9646:LOC100477312
gene id: 9646:LOC100477312
uniprot id: D2H9N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9646:GAD2
gene id: 9646:GAD2
uniprot id: D2HYX7
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9646:VPS13A
gene id: 9646:VPS13A
uniprot id: G1LFG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

9646:CPSF7
gene id: 9646:CPSF7
uniprot id: G1MDV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

9646:TMEM233
gene id: 9646:TMEM233
uniprot id: G1MC62
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9646:SLC25A13
gene id: 9646:SLC25A13
uniprot id: G1LV59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9646:ADRA1A
gene id: 9646:ADRA1A
uniprot id: G1L034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9646:VDAC2
gene id: 9646:VDAC2
uniprot id: G1L4H5
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

9646:BDKRB2
gene id: 9646:BDKRB2
uniprot id: G1LAZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9646:HK3
gene id: 9646:HK3
uniprot id: G1LLC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9646:IGBP1
gene id: 9646:IGBP1
uniprot id: A0A7N5P1T2
names: Similarity
messages: Belongs to the IGBP1/TAP42 family.

9646:POLD3
gene id: 9646:POLD3
uniprot id: G1MFJ5
names: Subcellular Location Annotation
messages: Nucleus

9646:MEOX1
gene id: 9646:MEOX1
uniprot id: D2HCT9
names: Subcellular Location Annotation
messages: Nucleus

9646:RPS27A
gene id: 9646:RPS27A
uniprot id: A0A7N5KHN5
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

9646:RAB27A
gene id: 9646:RAB27A
uniprot id: D2HKW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9646:CLRN3
gene id: 9646:CLRN3
uniprot id: D2HHV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9646:ACTN4
gene id: 9646:ACTN4
uniprot id: D2HTG8
names: Similarity
messages: Belongs to the alpha-actinin family.

9646:GCG
gene id: 9646:GCG
uniprot id: D2HQW4
names: Similarity
messages: Belongs to the glucagon family.

9646:ATP13A3
gene id: 9646:ATP13A3
uniprot id: A0A7N5J9H6
uniprot id: A0A7N5KEX8
uniprot id: G1LRV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9646:MAN2A1
gene id: 9646:MAN2A1
uniprot id: D2HDB2
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9646:NPR2
gene id: 9646:NPR2
uniprot id: D2HAL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9646:ST6GAL1
gene id: 9646:ST6GAL1
uniprot id: D2H070
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9646:LOC100499574
gene id: 9646:LOC100499574
uniprot id: Q5XLE5
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two delta chains and two alpha chains.
messages: Red blood cells.

9646:TNFSF10
gene id: 9646:TNFSF10
uniprot id: G1L2D8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9646:ACAD9
gene id: 9646:ACAD9
uniprot id: G1MA98
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9646:RAB9A
gene id: 9646:RAB9A
uniprot id: D2HXD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9646:SPO11
gene id: 9646:SPO11
uniprot id: D2H1Z1
uniprot id: G1M2C7
names: Similarity
messages: Belongs to the TOP6A family.

9646:SBK2
gene id: 9646:SBK2
uniprot id: A0A7N5K9T0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:SESN2
gene id: 9646:SESN2
uniprot id: G1LXT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9646:AK2
gene id: 9646:AK2
uniprot id: A0A7N5J995
uniprot id: A0A7N5JJ22
uniprot id: D2HI44
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9646:LOC100470296
gene id: 9646:LOC100470296
uniprot id: D2I8E6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:IL15
gene id: 9646:IL15
uniprot id: A0A7N5JBC7
uniprot id: B0ZE70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (By similarity). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).
messages: Secreted

9646:SLC25A31
gene id: 9646:SLC25A31
uniprot id: G1L752
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9646:SUDS3
gene id: 9646:SUDS3
uniprot id: G1MCC1
names: Subcellular Location Annotation
messages: Nucleus

9646:PLA2G15
gene id: 9646:PLA2G15
uniprot id: G1LN15
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9646:SRFBP1
gene id: 9646:SRFBP1
uniprot id: G1MI85
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9646:MVP
gene id: 9646:MVP
uniprot id: D2HX35
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

9646:MINDY1
gene id: 9646:MINDY1
uniprot id: G1L2N5
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9646:MRM1
gene id: 9646:MRM1
uniprot id: A0A7N5KBC3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

9646:RAG1
gene id: 9646:RAG1
uniprot id: D2HV49
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAG1 family.
messages: Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.
messages: Homodimer.
messages: Nucleus
messages: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.

9646:CPNE4
gene id: 9646:CPNE4
uniprot id: A0A7N5K7D1
names: Similarity
messages: Belongs to the copine family.

9646:SMIM15
gene id: 9646:SMIM15
uniprot id: D2H3U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9646:NUDCD1
gene id: 9646:NUDCD1
uniprot id: D2HA60
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:SLC39A2
gene id: 9646:SLC39A2
uniprot id: D2HYC9
names: Subcellular Location Annotation
messages: Membrane

9646:CLPTM1L
gene id: 9646:CLPTM1L
uniprot id: G1LVX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9646:RIF1
gene id: 9646:RIF1
uniprot id: A0A7N5JH00
uniprot id: A0A7N5KAA3
uniprot id: G1LPF7
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9646:CEP20
gene id: 9646:CEP20
uniprot id: G1LRS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9646:KIAA1191
gene id: 9646:KIAA1191
uniprot id: G1LK87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9646:LOC100473402
gene id: 9646:LOC100473402
uniprot id: G1MMN2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:PCYT1B
gene id: 9646:PCYT1B
uniprot id: G1M8I0
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9646:PPIH
gene id: 9646:PPIH
uniprot id: G1L0Z5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9646:CAND1
gene id: 9646:CAND1
uniprot id: G1LQ96
names: Similarity
messages: Belongs to the CAND family.

9646:TIMM10B
gene id: 9646:TIMM10B
uniprot id: G1MD05
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9646:EMSY
gene id: 9646:EMSY
uniprot id: A0A7N5JKD3
uniprot id: A0A7N5JWY3
uniprot id: A0A7N5KBQ2
uniprot id: A0A7N5P9I8
uniprot id: G1MEU6
names: Subcellular Location Annotation
messages: Nucleus

9646:PANX1
gene id: 9646:PANX1
uniprot id: G1LZM9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9646:EIF6
gene id: 9646:EIF6
uniprot id: G1LT74
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9646:RFPL4B
gene id: 9646:RFPL4B
uniprot id: G1MLK1
names: Subcellular Location Annotation
messages: Cytoplasm

9646:GAST
gene id: 9646:GAST
uniprot id: G1LG97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

9646:BCLAF3
gene id: 9646:BCLAF3
uniprot id: A0A7N5JM63
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9646:TMEM218
gene id: 9646:TMEM218
uniprot id: G1L256
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9646:TNFAIP3
gene id: 9646:TNFAIP3
uniprot id: D2H0U3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:NAP1L5
gene id: 9646:NAP1L5
uniprot id: G1MP62
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9646:LOC100470709
gene id: 9646:LOC100470709
uniprot id: G1ML39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CEP44
gene id: 9646:CEP44
uniprot id: G1M6H4
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

9646:DKC1
gene id: 9646:DKC1
uniprot id: G1L7S2
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9646:PNOC
gene id: 9646:PNOC
uniprot id: G1L9C2
names: Similarity
messages: Belongs to the opioid neuropeptide precursor family.

9646:FAP
gene id: 9646:FAP
uniprot id: G1LGG1
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9646:CASP3
gene id: 9646:CASP3
uniprot id: G1LPC3
names: Similarity
messages: Belongs to the peptidase C14A family.

9646:LOC100473053
gene id: 9646:LOC100473053
uniprot id: D2HW31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:DHDH
gene id: 9646:DHDH
uniprot id: G1M7U0
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9646:SLC27A6
gene id: 9646:SLC27A6
uniprot id: D2H7D9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9646:NPY
gene id: 9646:NPY
uniprot id: G1LHW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9646:SLC30A6
gene id: 9646:SLC30A6
uniprot id: A0A7N5JQE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9646:KHDRBS1
gene id: 9646:KHDRBS1
uniprot id: D2HI64
names: Similarity
messages: Belongs to the KHDRBS family.

9646:DDC
gene id: 9646:DDC
uniprot id: A0A7N5KAB3
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9646:DOK1
gene id: 9646:DOK1
uniprot id: D2HH52
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9646:UBE2L6
gene id: 9646:UBE2L6
uniprot id: G1M7H7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9646:CASP2
gene id: 9646:CASP2
uniprot id: A0A7N5KK81
uniprot id: G1LJ60
names: Similarity
messages: Belongs to the peptidase C14A family.

9646:INTS2
gene id: 9646:INTS2
uniprot id: G1LQ98
names: Similarity
messages: Belongs to the Integrator subunit 2 family.

9646:MRPL27
gene id: 9646:MRPL27
uniprot id: G1LZH3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9646:PRDM14
gene id: 9646:PRDM14
uniprot id: D2H9L4
names: Subcellular Location Annotation
messages: Nucleus

9646:PRR15L
gene id: 9646:PRR15L
uniprot id: A0A7N5KH38
names: Similarity
messages: Belongs to the PRR15 family.

9646:SAR1A
gene id: 9646:SAR1A
uniprot id: D2GXH1
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9646:CAMSAP2
gene id: 9646:CAMSAP2
uniprot id: A0A7N5KLE7
uniprot id: D2GZP3
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9646:SPACA4
gene id: 9646:SPACA4
uniprot id: G1MNE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9646:HTR1E
gene id: 9646:HTR1E
uniprot id: D2HQH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:XPO7
gene id: 9646:XPO7
uniprot id: A0A7N5JW40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9646:ARHGDIB
gene id: 9646:ARHGDIB
uniprot id: D2HZU9
names: Similarity
messages: Belongs to the Rho GDI family.

9646:CCT4
gene id: 9646:CCT4
uniprot id: G1LA28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9646:MEGF10
gene id: 9646:MEGF10
uniprot id: A0A7N5JZY1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:GANC
gene id: 9646:GANC
uniprot id: G1MCA4
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9646:SERPINA12
gene id: 9646:SERPINA12
uniprot id: D2HEM6
names: Similarity
messages: Belongs to the serpin family.

9646:RBM8A
gene id: 9646:RBM8A
uniprot id: G1MGY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9646:UFC1
gene id: 9646:UFC1
uniprot id: D2I0T5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.

9646:DR1
gene id: 9646:DR1
uniprot id: G1LT63
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9646:LOC100475278
gene id: 9646:LOC100475278
uniprot id: D2I466
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:AASDH
gene id: 9646:AASDH
uniprot id: A0A7N5JGP0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9646:IL17RC
gene id: 9646:IL17RC
uniprot id: G1MCL8
names: Subcellular Location Annotation
messages: Membrane

9646:ARID3B
gene id: 9646:ARID3B
uniprot id: D2HKY8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with ARID3A. Interacts with unphosphorylated RB1.
messages: Nucleus
messages: Transcription factor.

9646:FZD4
gene id: 9646:FZD4
uniprot id: D2HRQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

9646:ESS2
gene id: 9646:ESS2
uniprot id: D2HEX3
uniprot id: G1LXQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9646:TMEM126B
gene id: 9646:TMEM126B
uniprot id: G1LQ19
names: Subcellular Location Annotation
messages: Membrane

9646:UBALD1
gene id: 9646:UBALD1
uniprot id: D2HQ77
names: Similarity
messages: Belongs to the UBALD family.

9646:SLF2
gene id: 9646:SLF2
uniprot id: G1MGQ5
names: Similarity
messages: Belongs to the FAM178 family.

9646:TEKT5
gene id: 9646:TEKT5
uniprot id: D2HK12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9646:CHAC2
gene id: 9646:CHAC2
uniprot id: G1LD45
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9646:CDC34
gene id: 9646:CDC34
uniprot id: D2HMB9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9646:ACER1
gene id: 9646:ACER1
uniprot id: D2HY69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9646:FAM216A
gene id: 9646:FAM216A
uniprot id: G1M5S4
names: Similarity
messages: Belongs to the FAM216 family.

9646:GSTM3
gene id: 9646:GSTM3
uniprot id: G1LEK1
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9646:ANKH
gene id: 9646:ANKH
uniprot id: G1LT81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

9646:GOLT1B
gene id: 9646:GOLT1B
uniprot id: A0A7N5P6M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9646:BLCAP
gene id: 9646:BLCAP
uniprot id: D2H116
names: Similarity
messages: Belongs to the BLCAP family.

9646:RDH12
gene id: 9646:RDH12
uniprot id: G1LN50
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:PSENEN
gene id: 9646:PSENEN
uniprot id: D2HFS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9646:LOC100482919
gene id: 9646:LOC100482919
uniprot id: D2H5T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9646:SCARA5
gene id: 9646:SCARA5
uniprot id: D2GZ57
uniprot id: G1KZU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9646:LIG3
gene id: 9646:LIG3
uniprot id: A0A7N5JL15
uniprot id: G1M7L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9646:SCML4
gene id: 9646:SCML4
uniprot id: D2H6J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9646:FOXI1
gene id: 9646:FOXI1
uniprot id: D2I7N9
names: Subcellular Location Annotation
messages: Nucleus

9646:TFAP2B
gene id: 9646:TFAP2B
uniprot id: D2H1N5
names: Similarity
messages: Belongs to the AP-2 family.

9646:GPR180
gene id: 9646:GPR180
uniprot id: D2H9Z3
names: Subcellular Location Annotation
messages: Membrane

9646:H1-5
gene id: 9646:H1-5
uniprot id: D2HWI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9646:GPR33
gene id: 9646:GPR33
uniprot id: G1MN65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

9646:LOC100479689
gene id: 9646:LOC100479689
uniprot id: D2HTD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9646:TRIM45
gene id: 9646:TRIM45
uniprot id: D2HMJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9646:LOC100475247
gene id: 9646:LOC100475247
uniprot id: G1L8J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9646:LOC100464962
gene id: 9646:LOC100464962
uniprot id: D2I731
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:DUSP16
gene id: 9646:DUSP16
uniprot id: D2H873
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9646:ANXA9
gene id: 9646:ANXA9
uniprot id: D2HBT4
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9646:B4GALT2
gene id: 9646:B4GALT2
uniprot id: D2HSQ0
uniprot id: G1L2L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9646:CDC5L
gene id: 9646:CDC5L
uniprot id: G1LZ29
names: Similarity
messages: Belongs to the CEF1 family.

9646:ETV7
gene id: 9646:ETV7
uniprot id: A0A7N5KGB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:HK2
gene id: 9646:HK2
uniprot id: G1MFD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9646:LOC100471524
gene id: 9646:LOC100471524
uniprot id: D2HK52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:RANBP10
gene id: 9646:RANBP10
uniprot id: D2H9F5
names: Similarity
messages: Belongs to the RANBP9/10 family.

9646:CAB39L
gene id: 9646:CAB39L
uniprot id: D2HB73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9646:REXO2
gene id: 9646:REXO2
uniprot id: D2HVG0
names: Similarity
messages: Belongs to the oligoribonuclease family.

9646:LRFN3
gene id: 9646:LRFN3
uniprot id: D2HFT7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LRFN family.
messages: Can form heteromeric complexes with LRFN1, LRFN2, LRFN4 and LRFN5. Able to form homomeric complexes across cell junctions, between adjacent cells. Does not interact with DLG4 (By similarity).
messages: Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity).
messages: Cell membrane
messages: Lacks a cytoplasmic PDZ-binding domain, which has been implicated in function of related Lrfn proteins.
messages: N-glycosylated.
messages: Postsynaptic cell membrane
messages: Presynaptic cell membrane
messages: Synapse
messages: axon
messages: dendrite

9646:ATP5F1D
gene id: 9646:ATP5F1D
uniprot id: G1L969
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrion inner membrane

9646:SCRN3
gene id: 9646:SCRN3
uniprot id: G1M0M7
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9646:MFAP3
gene id: 9646:MFAP3
uniprot id: D2I7E5
names: Subcellular Location Annotation
messages: Cell membrane

9646:ODR4
gene id: 9646:ODR4
uniprot id: G1MAJ4
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

9646:IHH
gene id: 9646:IHH
uniprot id: D2GXC0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.

9646:FSCN3
gene id: 9646:FSCN3
uniprot id: G1LDA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9646:VAMP1
gene id: 9646:VAMP1
uniprot id: G1M7A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9646:FOXP1
gene id: 9646:FOXP1
uniprot id: G1M995
names: Subcellular Location Annotation
messages: Nucleus

9646:TMEM265
gene id: 9646:TMEM265
uniprot id: A0A7N5J8U8
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9646:TMOD4
gene id: 9646:TMOD4
uniprot id: D2HBS4
names: Subcellular Location Annotation
messages: cytoskeleton

9646:PIR
gene id: 9646:PIR
uniprot id: D2I1C1
names: Similarity
messages: Belongs to the pirin family.

9646:DDX3X
gene id: 9646:DDX3X
uniprot id: A0A7N5K269
uniprot id: G1LJW1
names: Similarity
messages: Belongs to the DEAD box helicase family.

9646:ZDHHC23
gene id: 9646:ZDHHC23
uniprot id: A0A7N5KB15
uniprot id: G1LFD6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9646:CCS
gene id: 9646:CCS
uniprot id: G1LWR7
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9646:APPL2
gene id: 9646:APPL2
uniprot id: A0A7N5JXB2
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9646:ADRB2
gene id: 9646:ADRB2
uniprot id: A0A7N5JT44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus
messages: Membrane

9646:TOP2A
gene id: 9646:TOP2A
uniprot id: A0A7N5PAN7
uniprot id: G1LN78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

9646:ATM
gene id: 9646:ATM
uniprot id: G1MEC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Cytoplasmic vesicle
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks.

9646:LOC100476661
gene id: 9646:LOC100476661
uniprot id: D2HRD0
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

9646:ACKR4
gene id: 9646:ACKR4
uniprot id: G1MPB3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:ADAM28
gene id: 9646:ADAM28
uniprot id: A0A7N5JMU1
uniprot id: A0A7N5P4W6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:NDUFA11
gene id: 9646:NDUFA11
uniprot id: G1LMS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Mitochondrion inner membrane

9646:RPS6KA2
gene id: 9646:RPS6KA2
uniprot id: A0A7N5KIY2
uniprot id: A0A7N5KL31
uniprot id: A0A7N5KP03
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9646:CD40
gene id: 9646:CD40
uniprot id: G1M2N0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:RBM3
gene id: 9646:RBM3
uniprot id: G1M1W2
names: Subcellular Location Annotation
messages: Cytoplasm

9646:LOC117794981
gene id: 9646:LOC117794981
uniprot id: D2CMN8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9646:AMD1
gene id: 9646:AMD1
uniprot id: D2HXL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9646:FOXJ1
gene id: 9646:FOXJ1
uniprot id: D2HD62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FOXJ1 family.
messages: Nucleus

9646:LYNX1
gene id: 9646:LYNX1
uniprot id: A0A7N5P869
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:FAM131B
gene id: 9646:FAM131B
uniprot id: G1LJE5
names: Similarity
messages: Belongs to the FAM131 family.

9646:OGDH
gene id: 9646:OGDH
uniprot id: A0A7N5KK68
uniprot id: D2HNP1
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9646:LAMTOR1
gene id: 9646:LAMTOR1
uniprot id: A0A7N5JC97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9646:GTF2H1
gene id: 9646:GTF2H1
uniprot id: D2HU87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9646:LOC100480278
gene id: 9646:LOC100480278
uniprot id: G1MCR5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:ARHGEF6
gene id: 9646:ARHGEF6
uniprot id: D2HD92
names: Subcellular Location Annotation
messages: lamellipodium

9646:SLC26A2
gene id: 9646:SLC26A2
uniprot id: D2H8M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion.

9646:NNT
gene id: 9646:NNT
uniprot id: G1LBH1
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9646:GUSB
gene id: 9646:GUSB
uniprot id: A0A7N5JBQ5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

9646:P2RY1
gene id: 9646:P2RY1
uniprot id: D2H406
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:LOC100476755
gene id: 9646:LOC100476755
uniprot id: G1L1E1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9646:LOC100470800
gene id: 9646:LOC100470800
uniprot id: G1MJY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CD93
gene id: 9646:CD93
uniprot id: G1LTF0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:SETD7
gene id: 9646:SETD7
uniprot id: G1LWT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9646:B3GAT1
gene id: 9646:B3GAT1
uniprot id: D2H5A6
uniprot id: G1LLP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:SIAH1
gene id: 9646:SIAH1
uniprot id: G1LUQ5
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9646:DDX4
gene id: 9646:DDX4
uniprot id: A0A7N5JG35
uniprot id: A0A7N5JKV9
uniprot id: A0A7N5PAS5
names: Similarity
messages: Belongs to the DEAD box helicase family.

9646:CDK5RAP3
gene id: 9646:CDK5RAP3
uniprot id: G1LDX7
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9646:GNG5
gene id: 9646:GNG5
uniprot id: D2I7X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9646:LOC105242197
gene id: 9646:LOC105242197
uniprot id: G1MNE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CNKSR3
gene id: 9646:CNKSR3
uniprot id: G1LLZ9
names: Similarity
messages: Belongs to the CNKSR family.

9646:LDB2
gene id: 9646:LDB2
uniprot id: G1L4J8
names: Similarity
messages: Belongs to the LDB family.

9646:FAM214B
gene id: 9646:FAM214B
uniprot id: D2I1Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

9646:SEC62
gene id: 9646:SEC62
uniprot id: G1LD82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:AP1M2
gene id: 9646:AP1M2
uniprot id: G1LXZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9646:ERC1
gene id: 9646:ERC1
uniprot id: G1LCC4
names: Subcellular Location Annotation
messages: Cytoplasm

9646:PLAU
gene id: 9646:PLAU
uniprot id: G1ME57
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:ELOVL4
gene id: 9646:ELOVL4
uniprot id: D2H3V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

9646:PARPBP
gene id: 9646:PARPBP
uniprot id: A0A7N5JFL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9646:PSMB4
gene id: 9646:PSMB4
uniprot id: G1L1C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9646:DNAJB14
gene id: 9646:DNAJB14
uniprot id: D2HYU0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:EIF2B2
gene id: 9646:EIF2B2
uniprot id: D2GZX4
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9646:SLC25A47
gene id: 9646:SLC25A47
uniprot id: G1LXA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:ARMC8
gene id: 9646:ARMC8
uniprot id: A0A7N5KLR1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:LOC100478021
gene id: 9646:LOC100478021
uniprot id: D2I470
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CTBS
gene id: 9646:CTBS
uniprot id: G1L0J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Lysosome

9646:SLC12A9
gene id: 9646:SLC12A9
uniprot id: D2HX03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9646:TRPV5
gene id: 9646:TRPV5
uniprot id: D2HP40
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:WASF1
gene id: 9646:WASF1
uniprot id: D2HSZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9646:SLC7A4
gene id: 9646:SLC7A4
uniprot id: G1LBQ6
names: Subcellular Location Annotation
messages: Membrane

9646:LTA
gene id: 9646:LTA
uniprot id: D2I4B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9646:GNS
gene id: 9646:GNS
uniprot id: G1MIJ5
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9646:MPP5
gene id: 9646:MPP5
uniprot id: D2HRH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: adherens junction
messages: tight junction

9646:PTGER3
gene id: 9646:PTGER3
uniprot id: A0A7N5JXX2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:API5
gene id: 9646:API5
uniprot id: A0A7N5JBE5
names: Similarity
messages: Belongs to the API5 family.

9646:MMRN1
gene id: 9646:MMRN1
uniprot id: G1M961
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:LOC100483758
gene id: 9646:LOC100483758
uniprot id: G1L550
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9646:RPS14
gene id: 9646:RPS14
uniprot id: D9ZLV2
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9646:RPN2
gene id: 9646:RPN2
uniprot id: G1M118
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9646:CFAP299
gene id: 9646:CFAP299
uniprot id: G1LF41
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

9646:HSPA8
gene id: 9646:HSPA8
uniprot id: D2GYC0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9646:SLC35A4
gene id: 9646:SLC35A4
uniprot id: D2GUP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9646:HSPA2
gene id: 9646:HSPA2
uniprot id: D2GYI3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9646:MX1
gene id: 9646:MX1
uniprot id: A0A7N5K8P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Cytoplasm

9646:ILVBL
gene id: 9646:ILVBL
uniprot id: D2HZA5
uniprot id: G1L6T9
names: Similarity
messages: Belongs to the TPP enzyme family.

9646:CLDN12
gene id: 9646:CLDN12
uniprot id: D2HE11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

9646:RORC
gene id: 9646:RORC
uniprot id: G1L0N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9646:FGF14
gene id: 9646:FGF14
uniprot id: G1MDQ3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9646:AQP8
gene id: 9646:AQP8
uniprot id: A0A7N5K324
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9646:GLA
gene id: 9646:GLA
uniprot id: D2I2M9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9646:AHSA1
gene id: 9646:AHSA1
uniprot id: D2HUS1
names: Similarity
messages: Belongs to the AHA1 family.

9646:HLF
gene id: 9646:HLF
uniprot id: D2HSP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9646:YIPF4
gene id: 9646:YIPF4
uniprot id: G1LM66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:APOC3
gene id: 9646:APOC3
uniprot id: A0A7N5JMU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Secreted

9646:NTF3
gene id: 9646:NTF3
uniprot id: A0A7N5JN60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

9646:RGS3
gene id: 9646:RGS3
uniprot id: A0A7N5P9P1
names: Subcellular Location Annotation
messages: Cytoplasm

9646:ARF4
gene id: 9646:ARF4
uniprot id: G1LZB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9646:FGF9
gene id: 9646:FGF9
uniprot id: D2I195
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9646:ENTPD5
gene id: 9646:ENTPD5
uniprot id: A0A7N5JSB4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9646:SAP18
gene id: 9646:SAP18
uniprot id: G1M7X4
names: Similarity
messages: Belongs to the SAP18 family.

9646:LOC100476962
gene id: 9646:LOC100476962
uniprot id: G1L9T8
names: Subcellular Location Annotation
messages: Chromosome

9646:ID2
gene id: 9646:ID2
uniprot id: D2HLK9
names: Subcellular Location Annotation
messages: Nucleus

9646:GPR1
gene id: 9646:GPR1
uniprot id: G1L8E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9646:EDEM2
gene id: 9646:EDEM2
uniprot id: D2H444
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9646:MAML2
gene id: 9646:MAML2
uniprot id: G1LMX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

9646:NPTXR
gene id: 9646:NPTXR
uniprot id: G1LWA7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:ACTBL2
gene id: 9646:ACTBL2
uniprot id: D2HU13
names: Similarity
messages: Belongs to the actin family.

9646:DUSP1
gene id: 9646:DUSP1
uniprot id: D2H5F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9646:CHL1
gene id: 9646:CHL1
uniprot id: A0A7N5KDX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Cell membrane

9646:GUCY1A1
gene id: 9646:GUCY1A1
uniprot id: D2HPI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9646:DECR2
gene id: 9646:DECR2
uniprot id: D2HDW2
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

9646:EEF1AKMT2
gene id: 9646:EEF1AKMT2
uniprot id: G1LBZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: Nucleus
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.

9646:CFAP298
gene id: 9646:CFAP298
uniprot id: D2HCH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9646:SPTLC2
gene id: 9646:SPTLC2
uniprot id: D2HUS2
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9646:LAMC2
gene id: 9646:LAMC2
uniprot id: G1L6E0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9646:KCNH5
gene id: 9646:KCNH5
uniprot id: A0A7N5P2X6
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100463849
gene id: 9646:LOC100463849
uniprot id: D2HSF7
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9646:KEG54 p05
gene id: 9646:KEG54_p05
uniprot id: A5JFK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9646:TRAPPC3L
gene id: 9646:TRAPPC3L
uniprot id: G1LGE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9646:FRRS1
gene id: 9646:FRRS1
uniprot id: G1LRB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

9646:BCLAF1
gene id: 9646:BCLAF1
uniprot id: G1LTX4
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9646:ELAVL2
gene id: 9646:ELAVL2
uniprot id: A0A7N5K9T7
names: Similarity
messages: Belongs to the RRM elav family.

9646:DMRTC2
gene id: 9646:DMRTC2
uniprot id: D2HNF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9646:ACER2
gene id: 9646:ACER2
uniprot id: D2H9N1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:TMEM176A
gene id: 9646:TMEM176A
uniprot id: G1M638
names: Similarity
messages: Belongs to the TMEM176 family.

9646:ZP4
gene id: 9646:ZP4
uniprot id: G1L8A3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Zona pellucida

9646:EPOR
gene id: 9646:EPOR
uniprot id: D2HGW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Membrane

9646:RNF4
gene id: 9646:RNF4
uniprot id: G1M732
names: Subcellular Location Annotation
messages: Nucleus

9646:ADSL
gene id: 9646:ADSL
uniprot id: G1LX74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

9646:RPS16
gene id: 9646:RPS16
uniprot id: F0UY67
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9646:LOC100484809
gene id: 9646:LOC100484809
uniprot id: D2I0A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9646:SLC25A32
gene id: 9646:SLC25A32
uniprot id: A0A7N5K686
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:ACSL5
gene id: 9646:ACSL5
uniprot id: G1MAK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9646:APLNR
gene id: 9646:APLNR
uniprot id: D2HK54
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:PTGFR
gene id: 9646:PTGFR
uniprot id: A0A7N5JGI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:SDHAF1
gene id: 9646:SDHAF1
uniprot id: D2HFT9
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

9646:HCN3
gene id: 9646:HCN3
uniprot id: D2HZK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9646:ZSCAN29
gene id: 9646:ZSCAN29
uniprot id: D2GW56
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9646:TAMM41
gene id: 9646:TAMM41
uniprot id: G1LWW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9646:HTR2B
gene id: 9646:HTR2B
uniprot id: D2H6T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9646:HTATSF1
gene id: 9646:HTATSF1
uniprot id: A0A7N5P5E3
uniprot id: G1L863
names: Similarity
messages: Belongs to the HTATSF1 family.

9646:GPD2
gene id: 9646:GPD2
uniprot id: D2HUI8
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

9646:C5AR2
gene id: 9646:C5AR2
uniprot id: D2HL40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

9646:PEX2
gene id: 9646:PEX2
uniprot id: D2HKR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9646:MIS12
gene id: 9646:MIS12
uniprot id: D2I1J3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9646:SLC5A2
gene id: 9646:SLC5A2
uniprot id: D2HTD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9646:TRIM56
gene id: 9646:TRIM56
uniprot id: D2I5Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9646:RFT1
gene id: 9646:RFT1
uniprot id: G1LN22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

9646:PGLYRP1
gene id: 9646:PGLYRP1
uniprot id: G1L198
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

9646:PARP8
gene id: 9646:PARP8
uniprot id: A0A7N5K0P6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9646:WASF2
gene id: 9646:WASF2
uniprot id: D2GWI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9646:POLR3G
gene id: 9646:POLR3G
uniprot id: D2GX78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

9646:PDCD10
gene id: 9646:PDCD10
uniprot id: D2H6S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9646:LOC100484841
gene id: 9646:LOC100484841
uniprot id: G1LN39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9646:CDH9
gene id: 9646:CDH9
uniprot id: D2H5S4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9646:LOC100476246
gene id: 9646:LOC100476246
uniprot id: G1M990
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9646:HYAL2
gene id: 9646:HYAL2
uniprot id: D2HES7
uniprot id: G1LZ03
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9646:TRPM8
gene id: 9646:TRPM8
uniprot id: G1MCC6
names: Subcellular Location Annotation
messages: Membrane

9646:GJA4
gene id: 9646:GJA4
uniprot id: D2H618
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9646:SLC25A27
gene id: 9646:SLC25A27
uniprot id: A0A7N5KLE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:HDHD2
gene id: 9646:HDHD2
uniprot id: G1M2C4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9646:IFNB1
gene id: 9646:IFNB1
uniprot id: D2H9N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9646:CDX4
gene id: 9646:CDX4
uniprot id: D2I4Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9646:RPL32
gene id: 9646:RPL32
uniprot id: F2X278
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9646:LOC100476018
gene id: 9646:LOC100476018
uniprot id: D2I3R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:PSMA3
gene id: 9646:PSMA3
uniprot id: G1L6X6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9646:TAC1
gene id: 9646:TAC1
uniprot id: A0A7N5JLI8
uniprot id: G1MD15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9646:AR
gene id: 9646:AR
uniprot id: D2I1X7
names: Similarity
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.

9646:LOC100473415
gene id: 9646:LOC100473415
uniprot id: D2GW51
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9646:LOC100472783
gene id: 9646:LOC100472783
uniprot id: D2HP43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:INHBA
gene id: 9646:INHBA
uniprot id: D2GYF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9646:RPS12
gene id: 9646:RPS12
uniprot id: F2X216
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9646:NAPB
gene id: 9646:NAPB
uniprot id: G1LTJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9646:CCL17
gene id: 9646:CCL17
uniprot id: A0A7N5JJY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9646:DIPK2B
gene id: 9646:DIPK2B
uniprot id: D2I209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9646:KCNA5
gene id: 9646:KCNA5
uniprot id: D2HEJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

9646:PRORP
gene id: 9646:PRORP
uniprot id: A0A7N5K0J7
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9646:EOGT
gene id: 9646:EOGT
uniprot id: D2HPQ6
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

9646:CHN1
gene id: 9646:CHN1
uniprot id: G1M0W4
names: Function
messages: GTPase-activating protein for p21-rac.

9646:ESX1
gene id: 9646:ESX1
uniprot id: G1L0R5
names: Subcellular Location Annotation
messages: Nucleus

9646:MRPS21
gene id: 9646:MRPS21
uniprot id: D2HBU5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9646:GUF1
gene id: 9646:GUF1
uniprot id: G1MCA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

9646:PPP2R5B
gene id: 9646:PPP2R5B
uniprot id: A0A7N5KL86
uniprot id: D2H4S3
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9646:NRN1
gene id: 9646:NRN1
uniprot id: A0A7N5KDJ5
names: Similarity
messages: Belongs to the neuritin family.

9646:IRF4
gene id: 9646:IRF4
uniprot id: D2I4K6
names: Subcellular Location Annotation
messages: Nucleus

9646:SCG3
gene id: 9646:SCG3
uniprot id: G1LRU2
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted
messages: secretory vesicle membrane

9646:LOC100476924
gene id: 9646:LOC100476924
uniprot id: A0A7N5P342
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9646:SLC6A18
gene id: 9646:SLC6A18
uniprot id: G1LVK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9646:ADIPOR1
gene id: 9646:ADIPOR1
uniprot id: D2HSE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9646:GEM
gene id: 9646:GEM
uniprot id: A0A7N5KAI4
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9646:CAVIN1
gene id: 9646:CAVIN1
uniprot id: D2HIT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9646:METTL3
gene id: 9646:METTL3
uniprot id: D2HYB7
names: Similarity
messages: Belongs to the MT-A70-like family.

9646:MPC2
gene id: 9646:MPC2
uniprot id: G1LI57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9646:B4GALT3
gene id: 9646:B4GALT3
uniprot id: D2I0T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9646:TDO2
gene id: 9646:TDO2
uniprot id: G1MAF5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:MGAT1
gene id: 9646:MGAT1
uniprot id: D2I5F9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

9646:LOC100474511
gene id: 9646:LOC100474511
uniprot id: D2I697
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GABRA1
gene id: 9646:GABRA1
uniprot id: A0A7N5JDL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:ZC3HC1
gene id: 9646:ZC3HC1
uniprot id: G1LFR0
names: Subcellular Location Annotation
messages: Nucleus

9646:CANX
gene id: 9646:CANX
uniprot id: G1LQL2
names: Similarity
messages: Belongs to the calreticulin family.

9646:SLC37A3
gene id: 9646:SLC37A3
uniprot id: G1MHM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9646:SLC25A39
gene id: 9646:SLC25A39
uniprot id: G1MJ63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9646:FUT8
gene id: 9646:FUT8
uniprot id: D2GYH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9646:ITGA10
gene id: 9646:ITGA10
uniprot id: G1MGX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9646:TCP11L2
gene id: 9646:TCP11L2
uniprot id: G1MC30
names: Similarity
messages: Belongs to the TCP11 family.

9646:GOLGA5
gene id: 9646:GOLGA5
uniprot id: D2HN66
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

9646:SLC41A1
gene id: 9646:SLC41A1
uniprot id: D2I002
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9646:RPTOR
gene id: 9646:RPTOR
uniprot id: G1MA15
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

9646:FAM8A1
gene id: 9646:FAM8A1
uniprot id: D2HW99
names: Subcellular Location Annotation
messages: Membrane

9646:MINDY3
gene id: 9646:MINDY3
uniprot id: D2I688
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9646:ST13
gene id: 9646:ST13
uniprot id: D2HWC9
names: Similarity
messages: Belongs to the FAM10 family.

9646:TMBIM1
gene id: 9646:TMBIM1
uniprot id: D2GXE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9646:SPIC
gene id: 9646:SPIC
uniprot id: A0A7N5JLJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:AVPR1A
gene id: 9646:AVPR1A
uniprot id: A0A7N5P086
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9646:KIF5C
gene id: 9646:KIF5C
uniprot id: A0A7N5KD14
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9646:LSM12
gene id: 9646:LSM12
uniprot id: D2HCU6
names: Similarity
messages: Belongs to the LSM12 family.

9646:YIPF2
gene id: 9646:YIPF2
uniprot id: A0A7N5JWL2
uniprot id: G1LWW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9646:TPMT
gene id: 9646:TPMT
uniprot id: D2HIB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

9646:RAB4B
gene id: 9646:RAB4B
uniprot id: G1M0L3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9646:TGFB2
gene id: 9646:TGFB2
uniprot id: A0A7N5KEX5
uniprot id: D2HL87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9646:SLC17A1
gene id: 9646:SLC17A1
uniprot id: G1LTP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

9646:ARL4D
gene id: 9646:ARL4D
uniprot id: D2HCT5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9646:IPPK
gene id: 9646:IPPK
uniprot id: D2HY02
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9646:ALG11
gene id: 9646:ALG11
uniprot id: G1LZH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

9646:SERINC4
gene id: 9646:SERINC4
uniprot id: G1M9L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9646:POLR2G
gene id: 9646:POLR2G
uniprot id: G1LIJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9646:BUD23
gene id: 9646:BUD23
uniprot id: G1LXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

9646:LOC117795019
gene id: 9646:LOC117795019
uniprot id: D2HU52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9646:PCK1
gene id: 9646:PCK1
uniprot id: D2H1Y7
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9646:RAPGEF2
gene id: 9646:RAPGEF2
uniprot id: A0A7N5JEP7
uniprot id: A0A7N5K7K6
uniprot id: A0A7N5K9E6
uniprot id: A0A7N5PAJ0
uniprot id: A0A7N5PAK5
uniprot id: G1L6X3
names: Similarity
messages: Belongs to the RAPGEF2 family.

9646:SF3B3
gene id: 9646:SF3B3
uniprot id: G1L613
names: Subcellular Location Annotation
messages: Nucleus

9646:TSFM
gene id: 9646:TSFM
uniprot id: G1LFS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

9646:LOC100483311
gene id: 9646:LOC100483311
uniprot id: D2I7N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:SPOUT1
gene id: 9646:SPOUT1
uniprot id: G1MBF5
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

9646:TMEM86B
gene id: 9646:TMEM86B
uniprot id: G1LA30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9646:DERL1
gene id: 9646:DERL1
uniprot id: D2HU53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9646:RAB33A
gene id: 9646:RAB33A
uniprot id: D2H9U8
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9646:NMUR2
gene id: 9646:NMUR2
uniprot id: G1LMG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9646:RPL19
gene id: 9646:RPL19
uniprot id: F2X258
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

9646:SLC25A38
gene id: 9646:SLC25A38
uniprot id: A0A7N5JEP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9646:LOC100477332
gene id: 9646:LOC100477332
uniprot id: D2HKT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:FABP6
gene id: 9646:FABP6
uniprot id: A0A7N5JY50
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9646:PNLIPRP1
gene id: 9646:PNLIPRP1
uniprot id: G1M5Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9646:LOC100481536
gene id: 9646:LOC100481536
uniprot id: G1MJG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9646:ANP32A
gene id: 9646:ANP32A
uniprot id: G1M6B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9646:KIF19
gene id: 9646:KIF19
uniprot id: G1L3F0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9646:LOC100472721
gene id: 9646:LOC100472721
uniprot id: A0A7N5J8E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ATR
gene id: 9646:ATR
uniprot id: G1M1R0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.

9646:CEMIP2
gene id: 9646:CEMIP2
uniprot id: D2H003
names: Similarity
messages: Belongs to the CEMIP family.

9646:TBX15
gene id: 9646:TBX15
uniprot id: D2HZH8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9646:GRK5
gene id: 9646:GRK5
uniprot id: A0A7N5KNA1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9646:ACTR1A
gene id: 9646:ACTR1A
uniprot id: A0A7N5K5G5
names: Similarity
messages: Belongs to the actin family.

9646:LOC100469032
gene id: 9646:LOC100469032
uniprot id: D2HX82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9646:TAF9B
gene id: 9646:TAF9B
uniprot id: G1MGX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9646:ERLIN2
gene id: 9646:ERLIN2
uniprot id: D2H695
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9646:DRD1
gene id: 9646:DRD1
uniprot id: D2HHS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
messages: Membrane
messages: dendritic spine

9646:KLHL15
gene id: 9646:KLHL15
uniprot id: A0A7N5JVU6
uniprot id: D2HXJ7
names: Subcellular Location Annotation
messages: Nucleus

9646:LXN
gene id: 9646:LXN
uniprot id: D2HAE3
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9646:NDST1
gene id: 9646:NDST1
uniprot id: G1LDA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9646:TAF7
gene id: 9646:TAF7
uniprot id: G1MP83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9646:LOC100479700
gene id: 9646:LOC100479700
uniprot id: A0A7N5P7H0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:B3GALT2
gene id: 9646:B3GALT2
uniprot id: D2HM04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:AFG1L
gene id: 9646:AFG1L
uniprot id: G1LNE7
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9646:EIF5
gene id: 9646:EIF5
uniprot id: G1MIN3
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9646:TCEANC2
gene id: 9646:TCEANC2
uniprot id: G1LT51
names: Subcellular Location Annotation
messages: Nucleus

9646:PHACTR1
gene id: 9646:PHACTR1
uniprot id: A0A7N5JY80
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9646:ORMDL3
gene id: 9646:ORMDL3
uniprot id: D2I2F3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Ceramide-sensitive subunit of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC1, SPTLC2/3 and SPTSSA/B.
messages: Ceramides bind to ORMDL3 N-terminus and stabilize it in a conformation that physically restricts the accessibility of the substrates to their binding sites in the serine palmitoyltransferase (SPT) complex, hence inhibiting SPT catalytic activity. In the absence of ceramides, the N-terminus is flexible and permits substrate binding, thus liberating SPT from inhibition.
messages: Endoplasmic reticulum membrane
messages: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis.
messages: When hydroxylated at Pro-137, ubiquitinated via 'Lys-48'-linkage, leading to proteasomal degradation. In endothelial cells, ORMDL3 proteasomal degradation is controlled by the sphingosine 1-phosphate receptor signaling pathway.

9646:SENP5
gene id: 9646:SENP5
uniprot id: A0A7N5P2J3
uniprot id: D2H4X5
uniprot id: G1LAH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9646:LOC100468240
gene id: 9646:LOC100468240
uniprot id: A0A7N5JUT3
names: Subcellular Location Annotation
messages: Nucleus

9646:SCN3B
gene id: 9646:SCN3B
uniprot id: A0A7N5JKX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9646:AQP9
gene id: 9646:AQP9
uniprot id: D2HF57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9646:MSRB2
gene id: 9646:MSRB2
uniprot id: G1LIG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9646:PIK3C2A
gene id: 9646:PIK3C2A
uniprot id: D2HRK9
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9646:POU2F2
gene id: 9646:POU2F2
uniprot id: A0A7N5KHW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9646:NBR1
gene id: 9646:NBR1
uniprot id: G1KZY2
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9646:PWWP3B
gene id: 9646:PWWP3B
uniprot id: G1MK03
names: Similarity
messages: Belongs to the PWWP3A family.

9646:BHMT
gene id: 9646:BHMT
uniprot id: G1LGI1
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9646:ABHD3
gene id: 9646:ABHD3
uniprot id: G1L745
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9646:FARSA
gene id: 9646:FARSA
uniprot id: G1M1C2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

9646:FABP7
gene id: 9646:FABP7
uniprot id: A0A7N5P874
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9646:LOC100476252
gene id: 9646:LOC100476252
uniprot id: D2HV26
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9646:ENPEP
gene id: 9646:ENPEP
uniprot id: G1M8R9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9646:EMC2
gene id: 9646:EMC2
uniprot id: G1M2I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

9646:LOC100481956
gene id: 9646:LOC100481956
uniprot id: A0A7N5KKQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ALX1
gene id: 9646:ALX1
uniprot id: D2HVJ0
names: Subcellular Location Annotation
messages: Nucleus

9646:STARD3
gene id: 9646:STARD3
uniprot id: D2I2G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9646:SPSB2
gene id: 9646:SPSB2
uniprot id: D2HJ04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9646:MASTL
gene id: 9646:MASTL
uniprot id: D2HXI8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Nucleus
messages: Phosphorylation at Thr-744 by CDK1 during M phase activates its kinase activity. Maximum phosphorylation occurs in prometaphase (By similarity).
messages: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity).
messages: centrosome

9646:LOC100463732
gene id: 9646:LOC100463732
uniprot id: A0A7N5JYG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9646:ART3
gene id: 9646:ART3
uniprot id: A0A7N5P680
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9646:GSTO2
gene id: 9646:GSTO2
uniprot id: G1MI73
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9646:GHITM
gene id: 9646:GHITM
uniprot id: G1LT79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9646:GPR4
gene id: 9646:GPR4
uniprot id: D2I073
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:GRIA1
gene id: 9646:GRIA1
uniprot id: A0A7N5K735
uniprot id: G1M786
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9646:RPL10A
gene id: 9646:RPL10A
uniprot id: F2X244
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9646:TLL1
gene id: 9646:TLL1
uniprot id: D2HGS4
uniprot id: G1LER7
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:LMLN
gene id: 9646:LMLN
uniprot id: G1LC10
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

9646:G6PC2
gene id: 9646:G6PC2
uniprot id: A0A7N5KAW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9646:CFAP126
gene id: 9646:CFAP126
uniprot id: G1MA04
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9646:KCNV2
gene id: 9646:KCNV2
uniprot id: D2HB59
names: Subcellular Location Annotation
messages: Membrane

9646:TMEM147
gene id: 9646:TMEM147
uniprot id: D2HFR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM147 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

9646:FLCN
gene id: 9646:FLCN
uniprot id: A0A7N5JRA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9646:NF2
gene id: 9646:NF2
uniprot id: A0A7N5JT76
uniprot id: A0A7N5JZ14
uniprot id: G1LNC1
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9646:ATG5
gene id: 9646:ATG5
uniprot id: D2HSI9
uniprot id: G1L3Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9646:LRP12
gene id: 9646:LRP12
uniprot id: A0A7N5P8Z8
uniprot id: D2H6W6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:MCIDAS
gene id: 9646:MCIDAS
uniprot id: G1LS83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9646:NAP1L2
gene id: 9646:NAP1L2
uniprot id: D2I4Q9
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9646:LOC100474824
gene id: 9646:LOC100474824
uniprot id: D2HP54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9646:C9H8orf37
gene id: 9646:C9H8orf37
uniprot id: D2HVB4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9646:SPCS1
gene id: 9646:SPCS1
uniprot id: G1LP81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:TM9SF4
gene id: 9646:TM9SF4
uniprot id: G1M4A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9646:CNPY2
gene id: 9646:CNPY2
uniprot id: D2H353
names: Similarity
messages: Belongs to the canopy family.

9646:SLC35A5
gene id: 9646:SLC35A5
uniprot id: G1MIF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9646:ELP6
gene id: 9646:ELP6
uniprot id: G1M2X7
names: Similarity
messages: Belongs to the ELP6 family.

9646:CD5L
gene id: 9646:CD5L
uniprot id: G1LCQ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:PPP1R3C
gene id: 9646:PPP1R3C
uniprot id: A0A7N5P0W8
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9646:HDAC3
gene id: 9646:HDAC3
uniprot id: G1LVB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9646:RPS11
gene id: 9646:RPS11
uniprot id: D3YC01
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9646:LEF1
gene id: 9646:LEF1
uniprot id: A0A7N5JPK5
uniprot id: A0A7N5JQR6
uniprot id: A0A7N5KEC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9646:CDCA7
gene id: 9646:CDCA7
uniprot id: G1L090
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:FAM53C
gene id: 9646:FAM53C
uniprot id: D2HK95
names: Similarity
messages: Belongs to the FAM53 family.

9646:FZD1
gene id: 9646:FZD1
uniprot id: D2HY60
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:LOC100471200
gene id: 9646:LOC100471200
uniprot id: A0A7N5P0W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ACAA2
gene id: 9646:ACAA2
uniprot id: A0A7N5JFE7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9646:ZFYVE26
gene id: 9646:ZFYVE26
uniprot id: D2H5P6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFYVE26 family.
messages: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A (By similarity).
messages: Midbody
messages: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity).
messages: The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.
messages: centrosome

9646:CXCR6
gene id: 9646:CXCR6
uniprot id: G1MM44
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:LAP3
gene id: 9646:LAP3
uniprot id: D2H3S4
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9646:LDB1
gene id: 9646:LDB1
uniprot id: D2GXV5
names: Similarity
messages: Belongs to the LDB family.

9646:TLE4
gene id: 9646:TLE4
uniprot id: G1LPR5
names: Similarity
messages: Belongs to the WD repeat Groucho/TLE family.

9646:UCP2
gene id: 9646:UCP2
uniprot id: D2H1F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:CFAP36
gene id: 9646:CFAP36
uniprot id: G1LB50
names: Similarity
messages: Belongs to the CFAP36 family.

9646:MCTP2
gene id: 9646:MCTP2
uniprot id: G1MBL6
names: Subcellular Location Annotation
messages: Membrane

9646:B3GNT4
gene id: 9646:B3GNT4
uniprot id: G1MMP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:HOXD1
gene id: 9646:HOXD1
uniprot id: D2I1F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9646:LOC100465394
gene id: 9646:LOC100465394
uniprot id: A0A7N5KEQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body
messages: Perikaryon
messages: Z line
messages: gem
messages: neuron projection

9646:CDH1
gene id: 9646:CDH1
uniprot id: G1LMI4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9646:LOC100469420
gene id: 9646:LOC100469420
uniprot id: A0A7N5JFV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9646:PTTG1
gene id: 9646:PTTG1
uniprot id: G1LJB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9646:LOC100478359
gene id: 9646:LOC100478359
uniprot id: G1LQU5
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9646:ADRM1
gene id: 9646:ADRM1
uniprot id: D2HT81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADRM1 family.
messages: Cytoplasm
messages: Nucleus

9646:SLC14A1
gene id: 9646:SLC14A1
uniprot id: D2H8J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9646:LOC100472740
gene id: 9646:LOC100472740
uniprot id: D2GYJ3
names: Similarity
messages: Belongs to the AAA ATPase family.

9646:REEP2
gene id: 9646:REEP2
uniprot id: G1MDP1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:UTP6
gene id: 9646:UTP6
uniprot id: G1LFU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

9646:BEST4
gene id: 9646:BEST4
uniprot id: D2HUP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9646:ABI1
gene id: 9646:ABI1
uniprot id: A0A7N5KB61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9646:DKK4
gene id: 9646:DKK4
uniprot id: D2H980
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9646:DDX55
gene id: 9646:DDX55
uniprot id: D2GW00
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9646:XRCC6
gene id: 9646:XRCC6
uniprot id: G1MAS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus

9646:SNRNP27
gene id: 9646:SNRNP27
uniprot id: G1MCC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9646:STMN4
gene id: 9646:STMN4
uniprot id: A0A7N5JQA7
uniprot id: A0A7N5KK72
uniprot id: G1L025
names: Similarity
messages: Belongs to the stathmin family.

9646:KCNJ14
gene id: 9646:KCNJ14
uniprot id: D2H7Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9646:WDR35
gene id: 9646:WDR35
uniprot id: G1L7P0
names: Function
names: Subcellular Location Annotation
messages: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
messages: centrosome
messages: cilium basal body

9646:IL17B
gene id: 9646:IL17B
uniprot id: A0A7N5JHK7
uniprot id: A0A7N5KGJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9646:DAZAP2
gene id: 9646:DAZAP2
uniprot id: G1L5L5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

9646:DTNA
gene id: 9646:DTNA
uniprot id: A0A7N5JQ06
uniprot id: A0A7N5K977
uniprot id: A0A7N5P786
uniprot id: G1L111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9646:SMC1B
gene id: 9646:SMC1B
uniprot id: G1LR03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9646:ANP32E
gene id: 9646:ANP32E
uniprot id: G1L4W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9646:ISCU
gene id: 9646:ISCU
uniprot id: G1MD98
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex.

9646:NARF
gene id: 9646:NARF
uniprot id: A0A7N5JSD9
names: Similarity
messages: Belongs to the NARF family.

9646:GCHFR
gene id: 9646:GCHFR
uniprot id: G1MEV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

9646:LOC100475765
gene id: 9646:LOC100475765
uniprot id: D2I361
names: Subcellular Location Annotation
messages: Secreted

9646:REEP6
gene id: 9646:REEP6
uniprot id: G1L8H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9646:HHIP
gene id: 9646:HHIP
uniprot id: A0A7N5P717
uniprot id: D2H3P9
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:CRYBA1
gene id: 9646:CRYBA1
uniprot id: G1LCF5
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9646:CDK2
gene id: 9646:CDK2
uniprot id: A0A7N5KN52
uniprot id: D2H336
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:CSF1R
gene id: 9646:CSF1R
uniprot id: G1LEV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9646:NUSAP1
gene id: 9646:NUSAP1
uniprot id: G1MED5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NUSAP family.
messages: Cytoplasm

9646:ITGB6
gene id: 9646:ITGB6
uniprot id: A0A7N5P9I1
uniprot id: G1M1V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

9646:AP2S1
gene id: 9646:AP2S1
uniprot id: E7BLG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

9646:AGBL5
gene id: 9646:AGBL5
uniprot id: D2GXM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.
messages: Midbody
messages: Nucleus
messages: cytosol
messages: spindle

9646:LOC100483310
gene id: 9646:LOC100483310
uniprot id: D2I7G9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9646:RBP1
gene id: 9646:RBP1
uniprot id: G1MB88
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9646:LOC100465091
gene id: 9646:LOC100465091
uniprot id: D2HMU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9646:BBS2
gene id: 9646:BBS2
uniprot id: G1ME56
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9646:INTS14
gene id: 9646:INTS14
uniprot id: D2GYT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9646:LIN7A
gene id: 9646:LIN7A
uniprot id: D2H508
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Postsynaptic density membrane
messages: tight junction

9646:ASB8
gene id: 9646:ASB8
uniprot id: D2HE78
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9646:CMTR1
gene id: 9646:CMTR1
uniprot id: D2HRF1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

9646:LDB3
gene id: 9646:LDB3
uniprot id: D2H1J8
names: Subcellular Location Annotation
messages: Z line

9646:SMIM14
gene id: 9646:SMIM14
uniprot id: A0A7N5P4H3
uniprot id: G1L8R2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9646:RPL38
gene id: 9646:RPL38
uniprot id: F2X289
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9646:CDH11
gene id: 9646:CDH11
uniprot id: D2HTK7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9646:C4H19orf25
gene id: 9646:C4H19orf25
uniprot id: G1L9K9
names: Similarity
messages: Belongs to the UPF0449 family.

9646:LOC100466194
gene id: 9646:LOC100466194
uniprot id: D2HWJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:MRPL28
gene id: 9646:MRPL28
uniprot id: G1LKE9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

9646:ATP1A1
gene id: 9646:ATP1A1
uniprot id: G1LEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9646:PIPOX
gene id: 9646:PIPOX
uniprot id: D2GU14
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9646:POLR3D
gene id: 9646:POLR3D
uniprot id: D2H045
names: Subcellular Location Annotation
messages: Nucleus

9646:PIN4
gene id: 9646:PIN4
uniprot id: A0A7N5KIY9
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

9646:SENP3
gene id: 9646:SENP3
uniprot id: D2HPW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9646:SEC11A
gene id: 9646:SEC11A
uniprot id: A0A7N5K6S1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:SCGN
gene id: 9646:SCGN
uniprot id: D2H2K4
names: Subcellular Location Annotation
messages: secretory vesicle membrane

9646:SPIN1
gene id: 9646:SPIN1
uniprot id: G1L9A6
names: Similarity
messages: Belongs to the SPIN/STSY family.

9646:NIPAL1
gene id: 9646:NIPAL1
uniprot id: A0A7N5P626
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9646:DYNLL1
gene id: 9646:DYNLL1
uniprot id: D2I5D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9646:ABL1
gene id: 9646:ABL1
uniprot id: D2H177
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9646:LOC109488335
gene id: 9646:LOC109488335
uniprot id: G1MFN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9646:PLTP
gene id: 9646:PLTP
uniprot id: G1M1Z4
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

9646:GATA5
gene id: 9646:GATA5
uniprot id: D2HT78
names: Subcellular Location Annotation
messages: Nucleus

9646:ZDHHC15
gene id: 9646:ZDHHC15
uniprot id: G1MGC4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9646:EIF3L
gene id: 9646:EIF3L
uniprot id: A0A7N5JI21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9646:PSPH
gene id: 9646:PSPH
uniprot id: D2HTC5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

9646:RRP12
gene id: 9646:RRP12
uniprot id: D2H5L2
names: Similarity
messages: Belongs to the RRP12 family.

9646:STX17
gene id: 9646:STX17
uniprot id: D2H0F8
names: Similarity
messages: Belongs to the syntaxin family.

9646:FAM167A
gene id: 9646:FAM167A
uniprot id: D2HMQ7
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9646:GPR156
gene id: 9646:GPR156
uniprot id: D2H189
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9646:SHCBP1
gene id: 9646:SHCBP1
uniprot id: G1MJ48
names: Subcellular Location Annotation
messages: spindle

9646:LOC100472056
gene id: 9646:LOC100472056
uniprot id: G1L8V2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Membrane
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9646:LOC105235700
gene id: 9646:LOC105235700
uniprot id: A0A7N5JLB0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:SEC61B
gene id: 9646:SEC61B
uniprot id: A0A7N5JGR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9646:EBNA1BP2
gene id: 9646:EBNA1BP2
uniprot id: D2HSR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

9646:IL17A
gene id: 9646:IL17A
uniprot id: A0A7N5KBI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9646:SLC40A1
gene id: 9646:SLC40A1
uniprot id: G1M0K1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

9646:COG7
gene id: 9646:COG7
uniprot id: D2HWL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:LOC100476988
gene id: 9646:LOC100476988
uniprot id: D2HQF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9646:TBCA
gene id: 9646:TBCA
uniprot id: A0A7N5JCN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

9646:PDE7B
gene id: 9646:PDE7B
uniprot id: A0A7N5KT71
uniprot id: G1LTS9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9646:DNASE2
gene id: 9646:DNASE2
uniprot id: G1M138
names: Similarity
messages: Belongs to the DNase II family.

9646:FBL
gene id: 9646:FBL
uniprot id: G1M1Y1
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9646:GTF2H4
gene id: 9646:GTF2H4
uniprot id: D2I123
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9646:FAM166A
gene id: 9646:FAM166A
uniprot id: G1MD64
names: Similarity
messages: Belongs to the CIMIP2 family.

9646:SESN1
gene id: 9646:SESN1
uniprot id: D2H6J8
uniprot id: G1LNK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9646:CLIC5
gene id: 9646:CLIC5
uniprot id: A0A7N5JR74
uniprot id: A0A7N5KF61
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9646:LOC100463574
gene id: 9646:LOC100463574
uniprot id: D2HHN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TLR2
gene id: 9646:TLR2
uniprot id: D2GXT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9646:S1PR2
gene id: 9646:S1PR2
uniprot id: D2HGZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:CXCL13
gene id: 9646:CXCL13
uniprot id: G1L6W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9646:ERLIN1
gene id: 9646:ERLIN1
uniprot id: G1LK53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9646:DPH3
gene id: 9646:DPH3
uniprot id: A0A7N5K1V7
names: Similarity
messages: Belongs to the DPH3 family.

9646:GFUS
gene id: 9646:GFUS
uniprot id: D2HIP4
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9646:GPR37
gene id: 9646:GPR37
uniprot id: D2HUB2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:RTN4
gene id: 9646:RTN4
uniprot id: A0A7N5P7W0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:GAS8
gene id: 9646:GAS8
uniprot id: G1L3Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum
messages: flagellum axoneme

9646:MFAP1
gene id: 9646:MFAP1
uniprot id: D2GW43
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9646:CFAP97D1
gene id: 9646:CFAP97D1
uniprot id: G1MJ11
names: Similarity
messages: Belongs to the CFAP97 family.

9646:CAPN3
gene id: 9646:CAPN3
uniprot id: A0A7N5K5S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9646:MEPCE
gene id: 9646:MEPCE
uniprot id: D2HX16
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9646:PON1
gene id: 9646:PON1
uniprot id: G1LUM0
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9646:TFRC
gene id: 9646:TFRC
uniprot id: G1LBB8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

9646:TMEM106B
gene id: 9646:TMEM106B
uniprot id: D2HN44
names: Similarity
messages: Belongs to the TMEM106 family.

9646:FAM126A
gene id: 9646:FAM126A
uniprot id: A0A7N5K9H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9646:DIABLO
gene id: 9646:DIABLO
uniprot id: A0A7N5P6F9
names: Subcellular Location Annotation
messages: Mitochondrion

9646:IFITM5
gene id: 9646:IFITM5
uniprot id: D2I618
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9646:NUDC
gene id: 9646:NUDC
uniprot id: D2GWI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

9646:DKK2
gene id: 9646:DKK2
uniprot id: D2H5H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9646:ZWILCH
gene id: 9646:ZWILCH
uniprot id: G1L993
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex.
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
messages: kinetochore

9646:LOC100469041
gene id: 9646:LOC100469041
uniprot id: G1M0N2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9646:ELF3
gene id: 9646:ELF3
uniprot id: D2GZM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:EML6
gene id: 9646:EML6
uniprot id: G1LBY5
names: Function
names: Similarity
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

9646:SOD1
gene id: 9646:SOD1
uniprot id: G1M910
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

9646:CDH6
gene id: 9646:CDH6
uniprot id: D2HD82
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9646:ASPHD2
gene id: 9646:ASPHD2
uniprot id: G1MI89
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9646:ELOVL1
gene id: 9646:ELOVL1
uniprot id: D2HSR2
uniprot id: G1L499
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9646:CCNY
gene id: 9646:CCNY
uniprot id: G1LVF3
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9646:SSTR2
gene id: 9646:SSTR2
uniprot id: D2HUB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9646:EEF1G
gene id: 9646:EEF1G
uniprot id: G1LJN0
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9646:ARAP2
gene id: 9646:ARAP2
uniprot id: G1LFY4
names: Subcellular Location Annotation
messages: Cytoplasm

9646:SLC25A21
gene id: 9646:SLC25A21
uniprot id: G1L847
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:NGF
gene id: 9646:NGF
uniprot id: D2HS24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted

9646:HTR1D
gene id: 9646:HTR1D
uniprot id: D2HCC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

9646:HSPA4L
gene id: 9646:HSPA4L
uniprot id: D2HIW9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9646:ATG101
gene id: 9646:ATG101
uniprot id: D2HHD9
names: Similarity
messages: Belongs to the ATG101 family.

9646:SAMD4B
gene id: 9646:SAMD4B
uniprot id: G1LPQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

9646:CCT7
gene id: 9646:CCT7
uniprot id: G1MAN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9646:GSTT2B
gene id: 9646:GSTT2B
uniprot id: D2HRC6
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

9646:TAF1B
gene id: 9646:TAF1B
uniprot id: G1LXU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

9646:EXOSC9
gene id: 9646:EXOSC9
uniprot id: G1LHU1
names: Subcellular Location Annotation
messages: Cytoplasm

9646:CRBN
gene id: 9646:CRBN
uniprot id: A0A7N5KNE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9646:VPS37A
gene id: 9646:VPS37A
uniprot id: D2HN29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9646:PHAX
gene id: 9646:PHAX
uniprot id: D2H8F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

9646:FAM122B
gene id: 9646:FAM122B
uniprot id: A0A7N5K7N9
uniprot id: D2HA97
uniprot id: G1L3D5
names: Similarity
messages: Belongs to the FAM122 family.

9646:EYA3
gene id: 9646:EYA3
uniprot id: A0A7N5KIV5
uniprot id: G1LXK1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9646:LOC100475174
gene id: 9646:LOC100475174
uniprot id: D2HVS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9646:FABP4
gene id: 9646:FABP4
uniprot id: G1M7P1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9646:SH3YL1
gene id: 9646:SH3YL1
uniprot id: A0A7N5PAV4
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

9646:MED1
gene id: 9646:MED1
uniprot id: G1LBE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9646:FAM110A
gene id: 9646:FAM110A
uniprot id: D2HSA7
names: Similarity
messages: Belongs to the FAM110 family.

9646:KIF3C
gene id: 9646:KIF3C
uniprot id: D2GXP2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9646:RNASE10
gene id: 9646:RNASE10
uniprot id: D2I2U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9646:GUCY2F
gene id: 9646:GUCY2F
uniprot id: D2HNT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

9646:EDIL3
gene id: 9646:EDIL3
uniprot id: G1LDJ9
uniprot id: G1LDK1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:PLK3
gene id: 9646:PLK3
uniprot id: G1M6J4
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9646:TXN
gene id: 9646:TXN
uniprot id: A0A7N5P2T0
names: Similarity
messages: Belongs to the thioredoxin family.

9646:MFSD14A
gene id: 9646:MFSD14A
uniprot id: D2HFE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9646:CD164
gene id: 9646:CD164
uniprot id: A0A7N5JER8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9646:INHBE
gene id: 9646:INHBE
uniprot id: D2H382
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9646:RPS7
gene id: 9646:RPS7
uniprot id: D2I2A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: centrosome

9646:SYNJ1
gene id: 9646:SYNJ1
uniprot id: D2HCG9
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9646:FAM216B
gene id: 9646:FAM216B
uniprot id: A0A7N5KDP0
names: Similarity
messages: Belongs to the FAM216 family.

9646:YPEL5
gene id: 9646:YPEL5
uniprot id: D2HY36
names: Similarity
messages: Belongs to the yippee family.

9646:FFAR1
gene id: 9646:FFAR1
uniprot id: D2HFR0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:PUS7
gene id: 9646:PUS7
uniprot id: D2GX88
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9646:RUSF1
gene id: 9646:RUSF1
uniprot id: D2HTD0
names: Similarity
messages: Belongs to the RUS1 family.

9646:SNX33
gene id: 9646:SNX33
uniprot id: D2HRK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9646:MSH2
gene id: 9646:MSH2
uniprot id: D2GUB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

9646:PIP
gene id: 9646:PIP
uniprot id: A0A7N5JEB8
names: Similarity
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1.

9646:DESI1
gene id: 9646:DESI1
uniprot id: D2I286
names: Similarity
messages: Belongs to the DeSI family.

9646:CASS4
gene id: 9646:CASS4
uniprot id: A0A7N5K146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9646:RANGRF
gene id: 9646:RANGRF
uniprot id: A0A7N5KN51
names: Similarity
messages: Belongs to the MOG1 family.

9646:CAMP
gene id: 9646:CAMP
uniprot id: G1L3J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9646:CTU2
gene id: 9646:CTU2
uniprot id: G1MIK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTU2/NCS2 family.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9646:TCEA2
gene id: 9646:TCEA2
uniprot id: G1L5E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9646:HMGCR
gene id: 9646:HMGCR
uniprot id: D2H687
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

9646:CD79A
gene id: 9646:CD79A
uniprot id: G1LCU5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:OSBPL11
gene id: 9646:OSBPL11
uniprot id: G1LC26
names: Similarity
messages: Belongs to the OSBP family.

9646:ATG12
gene id: 9646:ATG12
uniprot id: G1MF83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9646:SPNS3
gene id: 9646:SPNS3
uniprot id: G1M740
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9646:CLDN8
gene id: 9646:CLDN8
uniprot id: D2HNZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9646:ACSL6
gene id: 9646:ACSL6
uniprot id: A0A7N5KN80
uniprot id: G1MH10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9646:PARN
gene id: 9646:PARN
uniprot id: G1LXQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm

9646:WDR46
gene id: 9646:WDR46
uniprot id: D2GYZ9
names: Subcellular Location Annotation
messages: nucleolus

9646:PEX13
gene id: 9646:PEX13
uniprot id: G1MIU5
names: Similarity
messages: Belongs to the peroxin-13 family.

9646:RAP1GDS1
gene id: 9646:RAP1GDS1
uniprot id: A0A7N5JZ98
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion

9646:VPS8
gene id: 9646:VPS8
uniprot id: D2H298
names: Similarity
messages: Belongs to the VPS8 family.

9646:FGG
gene id: 9646:FGG
uniprot id: G1MJI1
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9646:CEP63
gene id: 9646:CEP63
uniprot id: G1L9R9
names: Similarity
messages: Belongs to the CEP63 family.

9646:FURIN
gene id: 9646:FURIN
uniprot id: D2HCZ3
names: Similarity
messages: Belongs to the peptidase S8 family.

9646:DDX24
gene id: 9646:DDX24
uniprot id: D2HNZ5
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9646:EMC3
gene id: 9646:EMC3
uniprot id: D2HRA1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9646:CACNB3
gene id: 9646:CACNB3
uniprot id: G1LKV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

9646:PTDSS1
gene id: 9646:PTDSS1
uniprot id: D2HFX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:LOC100477293
gene id: 9646:LOC100477293
uniprot id: G1LU63
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9646:HOPX
gene id: 9646:HOPX
uniprot id: A0A7N5JZV9
names: Subcellular Location Annotation
messages: Nucleus

9646:TFCP2
gene id: 9646:TFCP2
uniprot id: A0A7N5KNU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9646:HPS5
gene id: 9646:HPS5
uniprot id: A0A7N5KL40
uniprot id: G1MHK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

9646:PROP1
gene id: 9646:PROP1
uniprot id: A0A7N5JX62
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

9646:YTHDF3
gene id: 9646:YTHDF3
uniprot id: A0A7N5JWZ1
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9646:ATP6V0D2
gene id: 9646:ATP6V0D2
uniprot id: D2H5C5
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

9646:NDUFB11
gene id: 9646:NDUFB11
uniprot id: A0A7N5JB90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane

9646:MAB21L2
gene id: 9646:MAB21L2
uniprot id: D2GXR3
names: Similarity
messages: Belongs to the mab-21 family.

9646:WDFY2
gene id: 9646:WDFY2
uniprot id: G1LZP5
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9646:RIMKLB
gene id: 9646:RIMKLB
uniprot id: D2I202
names: Similarity
messages: Belongs to the RimK family.

9646:EEF1B2
gene id: 9646:EEF1B2
uniprot id: D2HEP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9646:LOC100464417
gene id: 9646:LOC100464417
uniprot id: D2HEH6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9646:RPS18
gene id: 9646:RPS18
uniprot id: A0A7N5KKJ7
uniprot id: F2X217
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.

9646:RARS1
gene id: 9646:RARS1
uniprot id: G1LKK0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9646:CLEC12A
gene id: 9646:CLEC12A
uniprot id: A0A7N5JXK5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:SNRPD1
gene id: 9646:SNRPD1
uniprot id: G1L726
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

9646:MNS1
gene id: 9646:MNS1
uniprot id: G1L8N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNS1 family.
messages: Nucleus
messages: cilium axoneme
messages: flagellum axoneme

9646:NPNT
gene id: 9646:NPNT
uniprot id: A0A7N5JE48
uniprot id: A0A7N5JSP9
uniprot id: G1MGH6
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:DPEP1
gene id: 9646:DPEP1
uniprot id: G1L304
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

9646:GADD45A
gene id: 9646:GADD45A
uniprot id: G1LCY5
names: Similarity
messages: Belongs to the GADD45 family.

9646:LOC100463577
gene id: 9646:LOC100463577
uniprot id: G1LRZ1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GGACT
gene id: 9646:GGACT
uniprot id: D2H0A7
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9646:PRPS1L1
gene id: 9646:PRPS1L1
uniprot id: D2H1H9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9646:EIF2S2
gene id: 9646:EIF2S2
uniprot id: A0A7N5KL16
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9646:CRYBB3
gene id: 9646:CRYBB3
uniprot id: G1MHV2
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9646:SGK1
gene id: 9646:SGK1
uniprot id: G1MC21
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:GSS
gene id: 9646:GSS
uniprot id: D2H442
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9646:STC1
gene id: 9646:STC1
uniprot id: D2H026
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9646:ELOVL3
gene id: 9646:ELOVL3
uniprot id: D2GXV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

9646:ELP3
gene id: 9646:ELP3
uniprot id: G1KZT7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9646:PLA2G2E
gene id: 9646:PLA2G2E
uniprot id: G1L8V5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9646:SV2C
gene id: 9646:SV2C
uniprot id: D2H691
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9646:LIN28B
gene id: 9646:LIN28B
uniprot id: A0A7N5JGP7
names: Similarity
messages: Belongs to the lin-28 family.

9646:GRPR
gene id: 9646:GRPR
uniprot id: D2HDU6
uniprot id: G1LV27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:SCRN2
gene id: 9646:SCRN2
uniprot id: D2H552
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9646:RPL18
gene id: 9646:RPL18
uniprot id: F2X256
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Rough endoplasmic reticulum

9646:PNPT1
gene id: 9646:PNPT1
uniprot id: G1LAW7
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

9646:NECAP2
gene id: 9646:NECAP2
uniprot id: G1L0Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9646:GPR141
gene id: 9646:GPR141
uniprot id: G1ML97
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:NDST2
gene id: 9646:NDST2
uniprot id: D2HEE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9646:CLDN18
gene id: 9646:CLDN18
uniprot id: D2HLW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9646:CCR2
gene id: 9646:CCR2
uniprot id: G1MMF1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:HADH
gene id: 9646:HADH
uniprot id: A0A7N5P6J6
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9646:LOC100466380
gene id: 9646:LOC100466380
uniprot id: D2GUM3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9646:EPHA7
gene id: 9646:EPHA7
uniprot id: D2HE60
names: Subcellular Location Annotation
messages: Membrane

9646:GMPR
gene id: 9646:GMPR
uniprot id: G1LC97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9646:ME2
gene id: 9646:ME2
uniprot id: D2H522
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9646:RPS8
gene id: 9646:RPS8
uniprot id: F2X209
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

9646:LOC100473443
gene id: 9646:LOC100473443
uniprot id: G1M7K0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9646:UCP3
gene id: 9646:UCP3
uniprot id: D2H1E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:LOC100471516
gene id: 9646:LOC100471516
uniprot id: D2HDV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

9646:RHBDD3
gene id: 9646:RHBDD3
uniprot id: A0A7N5J953
uniprot id: G1LP49
names: Subcellular Location Annotation
messages: Membrane

9646:GPD1
gene id: 9646:GPD1
uniprot id: G1L318
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9646:STAM
gene id: 9646:STAM
uniprot id: G1LVX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9646:LOC100480804
gene id: 9646:LOC100480804
uniprot id: G1MP63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9646:CERT1
gene id: 9646:CERT1
uniprot id: A0A7N5JZC6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

9646:USP14
gene id: 9646:USP14
uniprot id: A0A7N5K764
uniprot id: G1LJG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9646:RCAN1
gene id: 9646:RCAN1
uniprot id: G1LFA2
names: Similarity
messages: Belongs to the RCAN family.

9646:BGLAP
gene id: 9646:BGLAP
uniprot id: G1M772
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9646:CC2D1B
gene id: 9646:CC2D1B
uniprot id: G1LRN0
names: Similarity
messages: Belongs to the CC2D1 family.

9646:GNB1
gene id: 9646:GNB1
uniprot id: G1M4Q5
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9646:CAB39
gene id: 9646:CAB39
uniprot id: D2H6U4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9646:FLI1
gene id: 9646:FLI1
uniprot id: A0A7N5JHX5
uniprot id: G1L733
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:FBXO48
gene id: 9646:FBXO48
uniprot id: D2HS17
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.

9646:STX11
gene id: 9646:STX11
uniprot id: G1MNL9
names: Similarity
messages: Belongs to the syntaxin family.

9646:KRT39
gene id: 9646:KRT39
uniprot id: D2HR36
names: Similarity
messages: Belongs to the intermediate filament family.

9646:ERG28
gene id: 9646:ERG28
uniprot id: D2GZY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:LOC100463831
gene id: 9646:LOC100463831
uniprot id: A0A7N5JR96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:SNF8
gene id: 9646:SNF8
uniprot id: G1LEM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

9646:MRPL19
gene id: 9646:MRPL19
uniprot id: A0A7N5KCN8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9646:LOC100480823
gene id: 9646:LOC100480823
uniprot id: G1MMZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9646:TMEM45A
gene id: 9646:TMEM45A
uniprot id: G1LB66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9646:CDK2AP2
gene id: 9646:CDK2AP2
uniprot id: D2HGQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9646:FAM214A
gene id: 9646:FAM214A
uniprot id: G1LLI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

9646:IL1R1
gene id: 9646:IL1R1
uniprot id: G1M3C9
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9646:MRAP2
gene id: 9646:MRAP2
uniprot id: D2I5L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:CDK15
gene id: 9646:CDK15
uniprot id: A0A7N5KPN6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:KPNA5
gene id: 9646:KPNA5
uniprot id: G1LGT6
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9646:ADAT2
gene id: 9646:ADAT2
uniprot id: G1LYS1
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9646:LOC100470602
gene id: 9646:LOC100470602
uniprot id: D2HD52
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:NUP133
gene id: 9646:NUP133
uniprot id: D2HHC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

9646:CHMP1A
gene id: 9646:CHMP1A
uniprot id: G1L313
names: Similarity
messages: Belongs to the SNF7 family.

9646:PDE4C
gene id: 9646:PDE4C
uniprot id: A0A7N5JTE4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9646:NOS3
gene id: 9646:NOS3
uniprot id: G1M5X2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

9646:STAMBP
gene id: 9646:STAMBP
uniprot id: G1MG94
names: Similarity
messages: Belongs to the peptidase M67C family.

9646:PGAM2
gene id: 9646:PGAM2
uniprot id: D2HNN1
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9646:PIANP
gene id: 9646:PIANP
uniprot id: G1M6A4
names: Subcellular Location Annotation
messages: Membrane

9646:TEX10
gene id: 9646:TEX10
uniprot id: D2HZ39
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

9646:CYRIA
gene id: 9646:CYRIA
uniprot id: G1L2J0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9646:BACE1
gene id: 9646:BACE1
uniprot id: G1LPE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: trans-Golgi network

9646:COPS7A
gene id: 9646:COPS7A
uniprot id: D2HJ13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9646:CFAP91
gene id: 9646:CFAP91
uniprot id: G1LKP0
names: Similarity
messages: Belongs to the CFAP91 family.

9646:RHCE
gene id: 9646:RHCE
uniprot id: G1LUH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9646:CSTF1
gene id: 9646:CSTF1
uniprot id: D2HGJ1
names: Subcellular Location Annotation
messages: Nucleus

9646:SENP2
gene id: 9646:SENP2
uniprot id: G1MEF8
names: Similarity
messages: Belongs to the peptidase C48 family.

9646:TOR1AIP1
gene id: 9646:TOR1AIP1
uniprot id: A0A7N5JIJ6
uniprot id: D2HFH3
uniprot id: G1L8D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9646:IRAK2
gene id: 9646:IRAK2
uniprot id: A0A7N5K5Y6
uniprot id: G1MC45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

9646:SRP9
gene id: 9646:SRP9
uniprot id: D2HVN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Cytoplasm

9646:GOT1L1
gene id: 9646:GOT1L1
uniprot id: D2H699
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

9646:PLD3
gene id: 9646:PLD3
uniprot id: D2HMV7
names: Similarity
messages: Belongs to the phospholipase D family.

9646:VIRMA
gene id: 9646:VIRMA
uniprot id: G1LH02
names: Similarity
messages: Belongs to the vir family.

9646:C3
gene id: 9646:C3
uniprot id: G1LL53
names: Function
names: Subcellular Location Annotation
messages: Acts as a chemoattractant for neutrophils in chronic inflammation.
messages: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
messages: Secreted

9646:PGM2L1
gene id: 9646:PGM2L1
uniprot id: D2H1E5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9646:SLCO2B1
gene id: 9646:SLCO2B1
uniprot id: G1MFF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9646:ALAS1
gene id: 9646:ALAS1
uniprot id: D2HAU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9646:WDR18
gene id: 9646:WDR18
uniprot id: D2HMD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May play a role during development.
messages: nucleolus
messages: nucleoplasm

9646:PACC1
gene id: 9646:PACC1
uniprot id: A0A7N5K7Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9646:NFX1
gene id: 9646:NFX1
uniprot id: G1LLR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

9646:EPHA4
gene id: 9646:EPHA4
uniprot id: D2HRP3
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Membrane

9646:HENMT1
gene id: 9646:HENMT1
uniprot id: G1LCG3
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9646:CERS5
gene id: 9646:CERS5
uniprot id: D2HJD0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9646:RACK1
gene id: 9646:RACK1
uniprot id: A0A7N5JIE3
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

9646:MPP7
gene id: 9646:MPP7
uniprot id: G1LNG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: adherens junction
messages: tight junction

9646:NTN4
gene id: 9646:NTN4
uniprot id: G1L5X5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:THY1
gene id: 9646:THY1
uniprot id: G1LMF3
names: Subcellular Location Annotation
messages: Cell membrane

9646:EZH2
gene id: 9646:EZH2
uniprot id: A0A7N5KNT6
uniprot id: G1L7Y5
names: Subcellular Location Annotation
messages: Nucleus

9646:SSH3
gene id: 9646:SSH3
uniprot id: A0A7N5KND1
uniprot id: G1L1K5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9646:GBP5
gene id: 9646:GBP5
uniprot id: G1LS20
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9646:POLR3A
gene id: 9646:POLR3A
uniprot id: G1MHI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9646:MGST1
gene id: 9646:MGST1
uniprot id: D2HA64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9646:POLR3B
gene id: 9646:POLR3B
uniprot id: G1MC66
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9646:S100A1
gene id: 9646:S100A1
uniprot id: G1M0I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Mitochondrion

9646:RIBC1
gene id: 9646:RIBC1
uniprot id: D2HVU9
names: Similarity
messages: Belongs to the RIB43A family.

9646:TMED2
gene id: 9646:TMED2
uniprot id: D2GVZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9646:DUSP27
gene id: 9646:DUSP27
uniprot id: D2HX66
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9646:TRMT11
gene id: 9646:TRMT11
uniprot id: A0A7N5P5E2
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

9646:BARX2
gene id: 9646:BARX2
uniprot id: D2GUX7
names: Subcellular Location Annotation
messages: Nucleus

9646:TRMT2A
gene id: 9646:TRMT2A
uniprot id: G1LZ69
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:THNSL2
gene id: 9646:THNSL2
uniprot id: D2HJ86
names: Similarity
messages: Belongs to the threonine synthase family.

9646:WNK4
gene id: 9646:WNK4
uniprot id: D2HIU9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9646:KDM4A
gene id: 9646:KDM4A
uniprot id: D2HSQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9646:PTPN6
gene id: 9646:PTPN6
uniprot id: G1M5D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9646:BMPR1A
gene id: 9646:BMPR1A
uniprot id: G1LTU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9646:LOC100478197
gene id: 9646:LOC100478197
uniprot id: D2I6G5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9646:SLC52A2
gene id: 9646:SLC52A2
uniprot id: G1LGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9646:PNPLA6
gene id: 9646:PNPLA6
uniprot id: A0A7N5KFC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:SMPD1
gene id: 9646:SMPD1
uniprot id: G1MDB7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

9646:CARM1
gene id: 9646:CARM1
uniprot id: G1LX00
names: Subcellular Location Annotation
messages: Nucleus

9646:PTGER2
gene id: 9646:PTGER2
uniprot id: D2I4Z9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:NCSTN
gene id: 9646:NCSTN
uniprot id: G1M6K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9646:GOT2
gene id: 9646:GOT2
uniprot id: G1MG53
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9646:RAB43
gene id: 9646:RAB43
uniprot id: D2H7D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane

9646:RNASE13
gene id: 9646:RNASE13
uniprot id: D2HYC6
uniprot id: G1MP09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9646:ZDHHC1
gene id: 9646:ZDHHC1
uniprot id: G1MG82
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9646:HPS3
gene id: 9646:HPS3
uniprot id: A0A7N5JME9
uniprot id: A0A7N5JRL7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

9646:STAC3
gene id: 9646:STAC3
uniprot id: D2H379
names: Subcellular Location Annotation
messages: sarcolemma

9646:SPA17
gene id: 9646:SPA17
uniprot id: A0A7N5P1Y9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9646:GJD2
gene id: 9646:GJD2
uniprot id: G1LEY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9646:LOC100482979
gene id: 9646:LOC100482979
uniprot id: G1MIM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9646:CTSB
gene id: 9646:CTSB
uniprot id: D2HMR2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9646:SLC12A1
gene id: 9646:SLC12A1
uniprot id: D2H739
uniprot id: G1L5A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9646:BMPR1B
gene id: 9646:BMPR1B
uniprot id: D2H1C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9646:LOC100464665
gene id: 9646:LOC100464665
uniprot id: E5L4Y6
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9646:PER2
gene id: 9646:PER2
uniprot id: G1M8P6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:BEX3
gene id: 9646:BEX3
uniprot id: D2HTN8
names: Similarity
messages: Belongs to the BEX family.

9646:PARG
gene id: 9646:PARG
uniprot id: G1LLS0
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9646:SLC24A4
gene id: 9646:SLC24A4
uniprot id: G1M592
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9646:CTLA4
gene id: 9646:CTLA4
uniprot id: D2HDB8
uniprot id: G1L880
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9646:RDH5
gene id: 9646:RDH5
uniprot id: G1LZD8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:PHKA2
gene id: 9646:PHKA2
uniprot id: A0A7N5J9G3
uniprot id: A0A7N5JIW5
uniprot id: G1MEG4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9646:NIPA2
gene id: 9646:NIPA2
uniprot id: D2I443
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9646:GALNT6
gene id: 9646:GALNT6
uniprot id: G1L5F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9646:GREM2
gene id: 9646:GREM2
uniprot id: D2H9I0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:HMOX1
gene id: 9646:HMOX1
uniprot id: G1L3U2
names: Similarity
messages: Belongs to the heme oxygenase family.

9646:CSRNP3
gene id: 9646:CSRNP3
uniprot id: G1L6Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9646:KCNK2
gene id: 9646:KCNK2
uniprot id: A0A7N5K3M7
uniprot id: G1MBA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9646:TMEM38B
gene id: 9646:TMEM38B
uniprot id: D2HXY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9646:TMEM198
gene id: 9646:TMEM198
uniprot id: D2HQR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9646:ASIC2
gene id: 9646:ASIC2
uniprot id: G1LGP4
names: Subcellular Location Annotation
messages: Membrane

9646:STING1
gene id: 9646:STING1
uniprot id: G1LXK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9646:ST8SIA3
gene id: 9646:ST8SIA3
uniprot id: D2HE31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9646:C6H10orf53
gene id: 9646:C6H10orf53
uniprot id: G1LLE1
names: Similarity
messages: Belongs to the UPF0728 family.

9646:DENR
gene id: 9646:DENR
uniprot id: G1M8H4
names: Similarity
messages: Belongs to the DENR family.

9646:LOC100470415
gene id: 9646:LOC100470415
uniprot id: G1MN92
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9646:COPE
gene id: 9646:COPE
uniprot id: D2GV44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9646:IQSEC2
gene id: 9646:IQSEC2
uniprot id: A0A7N5JCS2
names: Similarity
messages: Belongs to the BRAG family.

9646:RDH11
gene id: 9646:RDH11
uniprot id: G1LN89
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:RPS5
gene id: 9646:RPS5
uniprot id: F2X205
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9646:XPO1
gene id: 9646:XPO1
uniprot id: D2HZX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9646:ARL14
gene id: 9646:ARL14
uniprot id: D2HVY5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9646:RPRD1A
gene id: 9646:RPRD1A
uniprot id: D2HQD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

9646:NRDE2
gene id: 9646:NRDE2
uniprot id: G1L4X0
names: Similarity
messages: Belongs to the NRDE2 family.

9646:TMEM14A
gene id: 9646:TMEM14A
uniprot id: G1L6G5
names: Similarity
messages: Belongs to the TMEM14 family.

9646:MMD
gene id: 9646:MMD
uniprot id: G1M848
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9646:DCP1A
gene id: 9646:DCP1A
uniprot id: G1LMP9
names: Similarity
messages: Belongs to the DCP1 family.

9646:PHTF2
gene id: 9646:PHTF2
uniprot id: A0A7N5P348
names: Subcellular Location Annotation
messages: Membrane

9646:MITF
gene id: 9646:MITF
uniprot id: A0A7N5KJH7
uniprot id: G1MFG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9646:DOLPP1
gene id: 9646:DOLPP1
uniprot id: G1MBT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9646:SAMHD1
gene id: 9646:SAMHD1
uniprot id: G1M1D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

9646:PPIC
gene id: 9646:PPIC
uniprot id: A0A7N5P0X8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9646:CES3
gene id: 9646:CES3
uniprot id: G1MFP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9646:ESRRG
gene id: 9646:ESRRG
uniprot id: A0A7N5JV70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9646:LOC100472074
gene id: 9646:LOC100472074
uniprot id: D2GVD1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9646:PLPP2
gene id: 9646:PLPP2
uniprot id: G1L749
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9646:NIPAL3
gene id: 9646:NIPAL3
uniprot id: G1LU09
uniprot id: G1LU11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9646:RPL7L1
gene id: 9646:RPL7L1
uniprot id: G1M2B5
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9646:MTG2
gene id: 9646:MTG2
uniprot id: A0A7N5P188
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9646:ADGRG7
gene id: 9646:ADGRG7
uniprot id: D2H5V7
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100483708
gene id: 9646:LOC100483708
uniprot id: A0A7N5JXS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9646:METTL4
gene id: 9646:METTL4
uniprot id: D2HU11
names: Similarity
messages: Belongs to the MT-A70-like family.

9646:PDGFRA
gene id: 9646:PDGFRA
uniprot id: G1MJ75
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9646:PRDX5
gene id: 9646:PRDX5
uniprot id: G1MHY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Peroxisome matrix
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

9646:PDRG1
gene id: 9646:PDRG1
uniprot id: G1M4S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9646:LOC100464745
gene id: 9646:LOC100464745
uniprot id: A0A7N5KPZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9646:NRM
gene id: 9646:NRM
uniprot id: A0A7N5KMV9
uniprot id: G1M3J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9646:PDCD11
gene id: 9646:PDCD11
uniprot id: G1MHX3
names: Subcellular Location Annotation
messages: nucleolus

9646:COG2
gene id: 9646:COG2
uniprot id: G1LSZ7
names: Similarity
messages: Belongs to the COG2 family.

9646:SSRP1
gene id: 9646:SSRP1
uniprot id: A0A7N5KJQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

9646:PACSIN1
gene id: 9646:PACSIN1
uniprot id: G1L2H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

9646:LOC100476606
gene id: 9646:LOC100476606
uniprot id: G1M9T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TM4SF19
gene id: 9646:TM4SF19
uniprot id: D2H4Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9646:CCT3
gene id: 9646:CCT3
uniprot id: A0A7N5JMS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9646:SNX6
gene id: 9646:SNX6
uniprot id: A0A7N5JG04
names: Similarity
messages: Belongs to the sorting nexin family.

9646:TSPAN1
gene id: 9646:TSPAN1
uniprot id: G1M5E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9646:LOC100484229
gene id: 9646:LOC100484229
uniprot id: G1MK09
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:KIF11
gene id: 9646:KIF11
uniprot id: G1M6D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle pole

9646:PCSK1
gene id: 9646:PCSK1
uniprot id: D2HUX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9646:RPLP0
gene id: 9646:RPLP0
uniprot id: F2X229
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9646:PRPF18
gene id: 9646:PRPF18
uniprot id: G1M4R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

9646:TXLNG
gene id: 9646:TXLNG
uniprot id: D2HDU3
names: Similarity
messages: Belongs to the taxilin family.

9646:SLC17A9
gene id: 9646:SLC17A9
uniprot id: G1MG20
uniprot id: G1MG22
names: Subcellular Location Annotation
messages: Membrane

9646:TSC22D3
gene id: 9646:TSC22D3
uniprot id: A0A7N5KJC8
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9646:FAM102A
gene id: 9646:FAM102A
uniprot id: G1M9M1
names: Similarity
messages: Belongs to the EEIG family.

9646:ACTA2
gene id: 9646:ACTA2
uniprot id: D2GZ42
names: Similarity
messages: Belongs to the actin family.

9646:MINPP1
gene id: 9646:MINPP1
uniprot id: D2GZ31
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

9646:FAM20B
gene id: 9646:FAM20B
uniprot id: D2H3L4
names: Similarity
messages: Belongs to the FAM20 family.

9646:THBS4
gene id: 9646:THBS4
uniprot id: G1MB47
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:ARF5
gene id: 9646:ARF5
uniprot id: G1LDA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9646:MRPS31
gene id: 9646:MRPS31
uniprot id: G1LZ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

9646:DEFB132
gene id: 9646:DEFB132
uniprot id: G1LXQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9646:LOC100468258
gene id: 9646:LOC100468258
uniprot id: G1MNW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TP53INP1
gene id: 9646:TP53INP1
uniprot id: A0A7N5JY93
uniprot id: D2HVB6
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9646:CCND2
gene id: 9646:CCND2
uniprot id: D2HEK1
names: Similarity
messages: Belongs to the cyclin family.

9646:QARS1
gene id: 9646:QARS1
uniprot id: D2HEW0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9646:MED7
gene id: 9646:MED7
uniprot id: D2GUH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9646:TAGLN3
gene id: 9646:TAGLN3
uniprot id: D2H6H8
names: Similarity
messages: Belongs to the calponin family.

9646:LOC100464796
gene id: 9646:LOC100464796
uniprot id: G1MMC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:LCNL1
gene id: 9646:LCNL1
uniprot id: A0A7N5JJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9646:LOC100478526
gene id: 9646:LOC100478526
uniprot id: D2I472
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:PDC
gene id: 9646:PDC
uniprot id: G1MAK0
names: Similarity
messages: Belongs to the phosducin family.

9646:ECHDC2
gene id: 9646:ECHDC2
uniprot id: G1LS80
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9646:TRAPPC1
gene id: 9646:TRAPPC1
uniprot id: D2HGD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9646:CRYAB
gene id: 9646:CRYAB
uniprot id: D2HG87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA.
messages: Nucleus

9646:ENOPH1
gene id: 9646:ENOPH1
uniprot id: G1LEU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9646:LOC100479137
gene id: 9646:LOC100479137
uniprot id: G1ML07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:MFN2
gene id: 9646:MFN2
uniprot id: G1LU66
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9646:USP37
gene id: 9646:USP37
uniprot id: G1L8C8
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9646:CLCN4
gene id: 9646:CLCN4
uniprot id: D2H0T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9646:GPI
gene id: 9646:GPI
uniprot id: D2HRQ7
names: Similarity
messages: Belongs to the GPI family.

9646:LOC100472977
gene id: 9646:LOC100472977
uniprot id: G1MNZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:IL1RN
gene id: 9646:IL1RN
uniprot id: G1LW10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

9646:YME1L1
gene id: 9646:YME1L1
uniprot id: G1L4Y5
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9646:DZIP1
gene id: 9646:DZIP1
uniprot id: A0A7N5JX32
uniprot id: G1LUU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: cilium basal body

9646:MTERF3
gene id: 9646:MTERF3
uniprot id: D2HFX7
names: Similarity
messages: Belongs to the mTERF family.

9646:FZD6
gene id: 9646:FZD6
uniprot id: D2I6J3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:TARS2
gene id: 9646:TARS2
uniprot id: G1L463
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9646:PPARD
gene id: 9646:PPARD
uniprot id: A0A7N5JAK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9646:SMAD4
gene id: 9646:SMAD4
uniprot id: D2H520
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9646:SV2B
gene id: 9646:SV2B
uniprot id: G1MBR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9646:FGF7
gene id: 9646:FGF7
uniprot id: D2H730
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9646:PLN
gene id: 9646:PLN
uniprot id: D2H9K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Sarcoplasmic reticulum membrane

9646:SNRPD2
gene id: 9646:SNRPD2
uniprot id: G1L1U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: cytosol

9646:TAGLN
gene id: 9646:TAGLN
uniprot id: D2HC73
names: Similarity
messages: Belongs to the calponin family.

9646:SHBG
gene id: 9646:SHBG
uniprot id: D2HPW8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:FGR
gene id: 9646:FGR
uniprot id: D2GWJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9646:ELOVL2
gene id: 9646:ELOVL2
uniprot id: G1L7F2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9646:PLIN5
gene id: 9646:PLIN5
uniprot id: G1L579
names: Similarity
messages: Belongs to the perilipin family.

9646:SURF4
gene id: 9646:SURF4
uniprot id: A0A7N5JKZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:HAL
gene id: 9646:HAL
uniprot id: G1L5Q5
names: Similarity
messages: Belongs to the PAL/histidase family.

9646:DBNDD2
gene id: 9646:DBNDD2
uniprot id: G1LC78
names: Similarity
messages: Belongs to the dysbindin family.

9646:CPB2
gene id: 9646:CPB2
uniprot id: G1M3G8
names: Similarity
messages: Belongs to the peptidase M14 family.

9646:LOC100465341
gene id: 9646:LOC100465341
uniprot id: D2HI20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC100467486
gene id: 9646:LOC100467486
uniprot id: G1LMC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9646:PERP
gene id: 9646:PERP
uniprot id: D2H0U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9646:B2M
gene id: 9646:B2M
uniprot id: A0A7N5K2L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-2-microglobulin family.
messages: Secreted

9646:THAP1
gene id: 9646:THAP1
uniprot id: D2H973
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9646:SNRPD3
gene id: 9646:SNRPD3
uniprot id: G1M5R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9646:ECRG4
gene id: 9646:ECRG4
uniprot id: A0A7N5KQR6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9646:TJP1
gene id: 9646:TJP1
uniprot id: A0A7N5K6U4
uniprot id: G1L8X7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9646:LOC100468438
gene id: 9646:LOC100468438
uniprot id: G1MJX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:RPL34
gene id: 9646:RPL34
uniprot id: D2H5G7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9646:OPN1SW
gene id: 9646:OPN1SW
uniprot id: D2GWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9646:JAGN1
gene id: 9646:JAGN1
uniprot id: D2HRA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:SLC49A3
gene id: 9646:SLC49A3
uniprot id: G1MEA6
names: Subcellular Location Annotation
messages: Membrane

9646:FUZ
gene id: 9646:FUZ
uniprot id: G1M551
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fuzzy family.
messages: cytoskeleton

9646:LOC100474410
gene id: 9646:LOC100474410
uniprot id: G1MKM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9646:POLR2D
gene id: 9646:POLR2D
uniprot id: D2HY08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

9646:UBE2K
gene id: 9646:UBE2K
uniprot id: G1L8Q8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9646:BCAT1
gene id: 9646:BCAT1
uniprot id: A0A7N5K284
uniprot id: G1LMC4
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9646:DHRS7B
gene id: 9646:DHRS7B
uniprot id: A0A7N5JQI5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:PSKH2
gene id: 9646:PSKH2
uniprot id: D2H5C4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:DLGAP4
gene id: 9646:DLGAP4
uniprot id: A0A7N5KLA4
uniprot id: D2H463
names: Similarity
messages: Belongs to the SAPAP family.

9646:PLRG1
gene id: 9646:PLRG1
uniprot id: G1MJH6
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9646:CROT
gene id: 9646:CROT
uniprot id: D2GY16
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9646:LOC100479323
gene id: 9646:LOC100479323
uniprot id: A0A7N5JSG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:MCOLN3
gene id: 9646:MCOLN3
uniprot id: D2HBY7
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9646:A4GNT
gene id: 9646:A4GNT
uniprot id: D2HLW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9646:RNASEH1
gene id: 9646:RNASEH1
uniprot id: G1MJF2
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9646:TRAPPC9
gene id: 9646:TRAPPC9
uniprot id: A0A7N5KMS3
names: Similarity
messages: Belongs to the NIBP family.

9646:TRH
gene id: 9646:TRH
uniprot id: D2HGM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Secreted

9646:TMEM17
gene id: 9646:TMEM17
uniprot id: D2HI02
names: Subcellular Location Annotation
messages: Membrane

9646:H1-2
gene id: 9646:H1-2
uniprot id: D2I084
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9646:LOC100475579
gene id: 9646:LOC100475579
uniprot id: D2HP59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:MST1R
gene id: 9646:MST1R
uniprot id: D2HET6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:GABRB2
gene id: 9646:GABRB2
uniprot id: D2GUJ8
uniprot id: G1LGA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:RPS28
gene id: 9646:RPS28
uniprot id: D2HZS4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

9646:POPDC3
gene id: 9646:POPDC3
uniprot id: D2H5S0
names: Similarity
messages: Belongs to the popeye family.

9646:AK6
gene id: 9646:AK6
uniprot id: G1L925
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9646:FMO5
gene id: 9646:FMO5
uniprot id: D2I2Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9646:RPL36AL
gene id: 9646:RPL36AL
uniprot id: D2HIE2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9646:MAGOH
gene id: 9646:MAGOH
uniprot id: D2H2F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9646:LOC100474749
gene id: 9646:LOC100474749
uniprot id: G1M0A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9646:THAP10
gene id: 9646:THAP10
uniprot id: D2HJ75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9646:TXNIP
gene id: 9646:TXNIP
uniprot id: D2HQ53
names: Similarity
messages: Belongs to the arrestin family.

9646:TREX2
gene id: 9646:TREX2
uniprot id: G1LQQ9
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9646:SF3A3
gene id: 9646:SF3A3
uniprot id: G1L393
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3A3 family.
messages: Nucleus

9646:AMPD1
gene id: 9646:AMPD1
uniprot id: A0A7N5JLH8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9646:LOC100483480
gene id: 9646:LOC100483480
uniprot id: D3YBZ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9646:SGMS2
gene id: 9646:SGMS2
uniprot id: D2H5H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9646:EIF2S1
gene id: 9646:EIF2S1
uniprot id: D2HRG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9646:LOC100472142
gene id: 9646:LOC100472142
uniprot id: G1LZZ8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CDKN1A
gene id: 9646:CDKN1A
uniprot id: A0A7N5JGR5
names: Similarity
messages: Belongs to the CDI family.

9646:EIF1B
gene id: 9646:EIF1B
uniprot id: A0A7N5JY87
names: Similarity
messages: Belongs to the SUI1 family.

9646:WTAP
gene id: 9646:WTAP
uniprot id: G1MAD4
names: Similarity
messages: Belongs to the fl(2)d family.

9646:LSM1
gene id: 9646:LSM1
uniprot id: G1LXB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9646:ANXA6
gene id: 9646:ANXA6
uniprot id: A0A7N5KQ14
uniprot id: G1LNP3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

9646:SNCB
gene id: 9646:SNCB
uniprot id: A0A7N5JGK6
names: Similarity
messages: Belongs to the synuclein family.

9646:KIF27
gene id: 9646:KIF27
uniprot id: D2H0N9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9646:GALNT3
gene id: 9646:GALNT3
uniprot id: D2HW57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9646:SDR16C5
gene id: 9646:SDR16C5
uniprot id: A0A7N5KMK4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:LHFPL1
gene id: 9646:LHFPL1
uniprot id: D2HIC3
names: Subcellular Location Annotation
messages: Membrane

9646:COPB1
gene id: 9646:COPB1
uniprot id: G1L6M9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9646:SLC6A12
gene id: 9646:SLC6A12
uniprot id: D2GYE2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Cell membrane
messages: Interacts with LIN7C.
messages: Lateral cell membrane
messages: Membrane

9646:FPR2
gene id: 9646:FPR2
uniprot id: D2HYN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

9646:TSPYL4
gene id: 9646:TSPYL4
uniprot id: G1MN34
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9646:LOC100475228
gene id: 9646:LOC100475228
uniprot id: D2HEK7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9646:PKM
gene id: 9646:PKM
uniprot id: G1LHU6
names: Similarity
messages: Belongs to the pyruvate kinase family.

9646:CLDN3
gene id: 9646:CLDN3
uniprot id: D2HMA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9646:RARB
gene id: 9646:RARB
uniprot id: G1L1L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9646:GFRA3
gene id: 9646:GFRA3
uniprot id: G1MDL5
names: Similarity
messages: Belongs to the GDNFR family.

9646:IL23A
gene id: 9646:IL23A
uniprot id: D2H355
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9646:ARCN1
gene id: 9646:ARCN1
uniprot id: A0A7N5JYC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9646:RGS12
gene id: 9646:RGS12
uniprot id: D2H4H4
names: Subcellular Location Annotation
messages: Cytoplasm

9646:MRPL58
gene id: 9646:MRPL58
uniprot id: D2HD32
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.
messages: Component of the mitochondrial 39S ribosomal subunit.
messages: Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity).
messages: In contrast to other members of the family, lacks the regions that come into close contact with the mRNA in the ribosomal A-site and determine the STOP codon specificity, explaining the loss of codon specificity for translation release factor activity.
messages: Mitochondrion

9646:TMEM106A
gene id: 9646:TMEM106A
uniprot id: D2I4D7
names: Similarity
messages: Belongs to the TMEM106 family.

9646:TMEM88B
gene id: 9646:TMEM88B
uniprot id: D2HPN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9646:ROPN1L
gene id: 9646:ROPN1L
uniprot id: G1LAP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

9646:LOC100468796
gene id: 9646:LOC100468796
uniprot id: A0A7N5KAC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9646:LOC100482539
gene id: 9646:LOC100482539
uniprot id: D2HZU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:SLC46A3
gene id: 9646:SLC46A3
uniprot id: G1LQT5
names: Subcellular Location Annotation
messages: Membrane

9646:ATP5F1A
gene id: 9646:ATP5F1A
uniprot id: G1M1T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9646:POLR2H
gene id: 9646:POLR2H
uniprot id: D2H2A3
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.

9646:SMUG1
gene id: 9646:SMUG1
uniprot id: G1L1H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9646:GALK2
gene id: 9646:GALK2
uniprot id: A0A7N5JLA0
uniprot id: G1L3S2
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9646:CHST4
gene id: 9646:CHST4
uniprot id: G1L6G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9646:LOC100475101
gene id: 9646:LOC100475101
uniprot id: D2I1N0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9646:EARS2
gene id: 9646:EARS2
uniprot id: G1M702
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9646:MFSD5
gene id: 9646:MFSD5
uniprot id: D2HLP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
messages: Membrane

9646:SMDT1
gene id: 9646:SMDT1
uniprot id: D2HVL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9646:LOC100467553
gene id: 9646:LOC100467553
uniprot id: A0A7N5JHJ4
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9646:GABPA
gene id: 9646:GABPA
uniprot id: G1MFL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:GALM
gene id: 9646:GALM
uniprot id: D2HNQ0
names: Similarity
messages: Belongs to the aldose epimerase family.

9646:PPFIA1
gene id: 9646:PPFIA1
uniprot id: A0A7N5K9Y5
uniprot id: A0A7N5KH37
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9646:HBP1
gene id: 9646:HBP1
uniprot id: G1M4G4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9646:ODF2
gene id: 9646:ODF2
uniprot id: A0A7N5JSH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9646:SLC35A3
gene id: 9646:SLC35A3
uniprot id: A0A7N5JYT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9646:MTNR1A
gene id: 9646:MTNR1A
uniprot id: G1LEM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9646:LAMTOR4
gene id: 9646:LAMTOR4
uniprot id: A0A7N5JRW2
uniprot id: G1M9M5
names: Similarity
messages: Belongs to the LAMTOR4 family.

9646:TNFSF13B
gene id: 9646:TNFSF13B
uniprot id: D2H2R1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9646:CCDC181
gene id: 9646:CCDC181
uniprot id: D2H9T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton

9646:GMFG
gene id: 9646:GMFG
uniprot id: G1LPR7
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9646:NUDT12
gene id: 9646:NUDT12
uniprot id: D2HL84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

9646:LYAR
gene id: 9646:LYAR
uniprot id: D2HLR9
names: Subcellular Location Annotation
messages: Cytoplasm

9646:LOC100480842
gene id: 9646:LOC100480842
uniprot id: G1MFC0
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9646:DPM2
gene id: 9646:DPM2
uniprot id: G1M9J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

9646:CXCL8
gene id: 9646:CXCL8
uniprot id: A0A7N5JZA1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

9646:DCLK2
gene id: 9646:DCLK2
uniprot id: A0A7N5JM59
uniprot id: D2I3C6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: Binds to and stabilizes microtubules. Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin.
messages: Protein kinase with a significantly reduced Ca(2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).
messages: The doublecortin domains are involved in the colocalization with microtubules.
messages: cytoskeleton

9646:CNR2
gene id: 9646:CNR2
uniprot id: G1MPF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:SLC44A4
gene id: 9646:SLC44A4
uniprot id: G1M305
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9646:ADD1
gene id: 9646:ADD1
uniprot id: D2H4G8
uniprot id: G1M7G5
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9646:TSPAN9
gene id: 9646:TSPAN9
uniprot id: G1LEE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9646:HESX1
gene id: 9646:HESX1
uniprot id: A0A7N5P3Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

9646:CPNE8
gene id: 9646:CPNE8
uniprot id: G1LWN0
names: Similarity
messages: Belongs to the copine family.

9646:GPATCH11
gene id: 9646:GPATCH11
uniprot id: G1MGQ2
names: Similarity
messages: Belongs to the GPATCH11 family.

9646:MC4R
gene id: 9646:MC4R
uniprot id: D2HQE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9646:TRIM36
gene id: 9646:TRIM36
uniprot id: A0A7N5P0X7
names: Subcellular Location Annotation
messages: cytoskeleton

9646:LOC100475194
gene id: 9646:LOC100475194
uniprot id: G1MNG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:ADIPOR2
gene id: 9646:ADIPOR2
uniprot id: D2GYD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9646:LOC100470732
gene id: 9646:LOC100470732
uniprot id: A0A7N5JMN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GATC
gene id: 9646:GATC
uniprot id: G1M3T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9646:ATP5F1B
gene id: 9646:ATP5F1B
uniprot id: D2H363
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9646:ESD
gene id: 9646:ESD
uniprot id: A0A7N5JJH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9646:MMS19
gene id: 9646:MMS19
uniprot id: D2H5K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9646:PROK1
gene id: 9646:PROK1
uniprot id: G1LYC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9646:DYNLT1
gene id: 9646:DYNLT1
uniprot id: G1LSC2
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9646:LOC100482725
gene id: 9646:LOC100482725
uniprot id: D2GVN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9646:LSM14B
gene id: 9646:LSM14B
uniprot id: A0A7N5JZ05
uniprot id: G1M488
names: Similarity
messages: Belongs to the LSM14 family.

9646:LSM14A
gene id: 9646:LSM14A
uniprot id: A0A7N5P8L1
uniprot id: G1MF04
names: Similarity
messages: Belongs to the LSM14 family.

9646:KIF21A
gene id: 9646:KIF21A
uniprot id: G1M2Y6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9646:TSPAN15
gene id: 9646:TSPAN15
uniprot id: D2GXH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9646:CHMP7
gene id: 9646:CHMP7
uniprot id: D2H033
names: Similarity
messages: Belongs to the SNF7 family.

9646:CERS6
gene id: 9646:CERS6
uniprot id: A0A7N5KBY6
uniprot id: G1LWK5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9646:SLIT2
gene id: 9646:SLIT2
uniprot id: A0A7N5JW75
uniprot id: G1LIJ7
uniprot id: G1LIL3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:ARL3
gene id: 9646:ARL3
uniprot id: G1MHI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9646:RCAN3
gene id: 9646:RCAN3
uniprot id: D2GWE0
names: Similarity
messages: Belongs to the RCAN family.

9646:LOC100467091
gene id: 9646:LOC100467091
uniprot id: G1MJL7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:FUT7
gene id: 9646:FUT7
uniprot id: G1M4A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9646:FOXK1
gene id: 9646:FOXK1
uniprot id: D2H492
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100474580
gene id: 9646:LOC100474580
uniprot id: G1MIL3
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.

9646:SCN7A
gene id: 9646:SCN7A
uniprot id: G1L3G6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9646:RPS27
gene id: 9646:RPS27
uniprot id: F2X226
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9646:CTTNBP2
gene id: 9646:CTTNBP2
uniprot id: G1L2X2
names: Subcellular Location Annotation
messages: cell cortex
messages: dendritic spine

9646:VPS11
gene id: 9646:VPS11
uniprot id: A0A7N5JNH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9646:AKAP5
gene id: 9646:AKAP5
uniprot id: D2GYI6
names: Subcellular Location Annotation
messages: Membrane

9646:GASK1A
gene id: 9646:GASK1A
uniprot id: G1M157
names: Similarity
messages: Belongs to the GASK family.

9646:PSMD5
gene id: 9646:PSMD5
uniprot id: D2H311
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

9646:CRAT
gene id: 9646:CRAT
uniprot id: A0A7N5KBU2
uniprot id: G1MBW9
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9646:LOC100466374
gene id: 9646:LOC100466374
uniprot id: A0A7N5P7E5
names: Similarity
messages: Belongs to the MHC class I family.

9646:DCPS
gene id: 9646:DCPS
uniprot id: D2HV04
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.

9646:YTHDC1
gene id: 9646:YTHDC1
uniprot id: G1LGJ3
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9646:TAF13
gene id: 9646:TAF13
uniprot id: A0A7N5P754
names: Subcellular Location Annotation
messages: Nucleus

9646:NPC1
gene id: 9646:NPC1
uniprot id: A0A7N5KGZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9646:TSPAN12
gene id: 9646:TSPAN12
uniprot id: G1LH97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9646:NEDD8
gene id: 9646:NEDD8
uniprot id: G1MCQ9
names: Similarity
messages: Belongs to the ubiquitin family.

9646:LOC100481707
gene id: 9646:LOC100481707
uniprot id: G1LXX3
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9646:SUPT16H
gene id: 9646:SUPT16H
uniprot id: G1LIN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9646:ATP6V1G3
gene id: 9646:ATP6V1G3
uniprot id: D2GZP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9646:LOC100470779
gene id: 9646:LOC100470779
uniprot id: G1M6W8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9646:FLNC
gene id: 9646:FLNC
uniprot id: A0A7N5KKU8
uniprot id: G1LEN3
names: Similarity
messages: Belongs to the filamin family.

9646:GINS4
gene id: 9646:GINS4
uniprot id: D2H9P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus

9646:SSBP1
gene id: 9646:SSBP1
uniprot id: G1M9E9
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9646:SLC50A1
gene id: 9646:SLC50A1
uniprot id: G1LXW3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

9646:MVB12A
gene id: 9646:MVB12A
uniprot id: G1LVI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9646:C10H16orf91
gene id: 9646:C10H16orf91
uniprot id: G1LMX0
names: Similarity
messages: Belongs to the UQCC4 family.

9646:USP44
gene id: 9646:USP44
uniprot id: D2HBJ8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP44 subfamily.
messages: Cytoplasm
messages: Dephosphorylated by CTDP1.
messages: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Promotes also the deubiquitination of histone H2A and H2B. Recruited to RNF8/RNF168-ubiquitinated chromatin surrounding double stranded breaks (DSBs), promotes hydrolysis of such ubiquitin conjugates, thus negatively regulating protein recruitment to damaged chromatin (By similarity). Participates in nucleotide excision repair (NER) pathway by deubiquitinating DDB2 to prevent its premature degradation so it can remain on damaged chromatin (By similarity). Promotes FOXP3 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability and increased regulatory T-cell lineage stability. Plays also a positive role in innate immune response to DNA viruses by deubiquitinating STING1, selectively removing its 'Lys-48'-linked polyubiquitin chains and stabilizing it (By similarity).
messages: Interacts with the N-CoR components TBL1X and TBL1XR1.
messages: Nucleus
messages: Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination and is degraded by the proteasome.

9646:PI4K2B
gene id: 9646:PI4K2B
uniprot id: D2I456
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9646:ITK
gene id: 9646:ITK
uniprot id: G1LHK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9646:TMEM9B
gene id: 9646:TMEM9B
uniprot id: A0A7N5JT80
uniprot id: G1LBR7
names: Similarity
messages: Belongs to the TMEM9 family.

9646:LOC100469647
gene id: 9646:LOC100469647
uniprot id: D2I7Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC100475425
gene id: 9646:LOC100475425
uniprot id: A0A7N5JH76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9646:ENO2
gene id: 9646:ENO2
uniprot id: D2HJ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9646:CD68
gene id: 9646:CD68
uniprot id: D2HPW6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9646:SPR
gene id: 9646:SPR
uniprot id: D2H0C8
names: Similarity
messages: Belongs to the sepiapterin reductase family.

9646:TMEM35A
gene id: 9646:TMEM35A
uniprot id: D2I0B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9646:MOV10
gene id: 9646:MOV10
uniprot id: D2H8X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

9646:RPL13A
gene id: 9646:RPL13A
uniprot id: F2X250
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9646:EIF2B4
gene id: 9646:EIF2B4
uniprot id: G1L421
uniprot id: G1L431
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9646:CDK8
gene id: 9646:CDK8
uniprot id: D2HP84
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:PLPP1
gene id: 9646:PLPP1
uniprot id: A0A7N5JEA8
uniprot id: G1M5Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9646:USB1
gene id: 9646:USB1
uniprot id: A0A7N5KFE5
uniprot id: G1MFP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9646:TLR3
gene id: 9646:TLR3
uniprot id: D2HM22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9646:MDM4
gene id: 9646:MDM4
uniprot id: G1L2U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

9646:PANX3
gene id: 9646:PANX3
uniprot id: D2HNJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9646:VPS28
gene id: 9646:VPS28
uniprot id: G1LGG4
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

9646:ACTG1
gene id: 9646:ACTG1
uniprot id: D2I7P0
names: Similarity
messages: Belongs to the actin family.

9646:COPS4
gene id: 9646:COPS4
uniprot id: G1LEI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9646:MIP
gene id: 9646:MIP
uniprot id: D2H358
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9646:XKR9
gene id: 9646:XKR9
uniprot id: D2H9L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9646:DLL4
gene id: 9646:DLL4
uniprot id: G1MEL4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9646:BCL2A1
gene id: 9646:BCL2A1
uniprot id: G1LIJ8
names: Similarity
messages: Belongs to the Bcl-2 family.

9646:DPM1
gene id: 9646:DPM1
uniprot id: G1M3Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9646:LOC100466373
gene id: 9646:LOC100466373
uniprot id: D2I4V2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:INTS7
gene id: 9646:INTS7
uniprot id: G1L352
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9646:PLAA
gene id: 9646:PLAA
uniprot id: D2I1P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

9646:BCAN
gene id: 9646:BCAN
uniprot id: G1M8L0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9646:UXS1
gene id: 9646:UXS1
uniprot id: D2GWY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

9646:CDH19
gene id: 9646:CDH19
uniprot id: D2HIK2
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9646:LOC100482014
gene id: 9646:LOC100482014
uniprot id: D2HLL2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9646:CCDC58
gene id: 9646:CCDC58
uniprot id: A0A7N5KD84
names: Similarity
messages: Belongs to the MIX23 family.

9646:FAM174A
gene id: 9646:FAM174A
uniprot id: D2HAA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9646:UVSSA
gene id: 9646:UVSSA
uniprot id: A0A7N5JRC2
uniprot id: G1MES7
names: Similarity
messages: Belongs to the UVSSA family.

9646:LOC100468508
gene id: 9646:LOC100468508
uniprot id: G1MNW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:C3H5orf22
gene id: 9646:C3H5orf22
uniprot id: G1LHL1
names: Similarity
messages: Belongs to the UPF0489 family.

9646:POLH
gene id: 9646:POLH
uniprot id: D2GZB3
names: Subcellular Location Annotation
messages: Nucleus

9646:GABARAPL2
gene id: 9646:GABARAPL2
uniprot id: G1LFR7
names: Similarity
messages: Belongs to the ATG8 family.

9646:ARPC3
gene id: 9646:ARPC3
uniprot id: G1M5V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9646:LOC109488326
gene id: 9646:LOC109488326
uniprot id: G1LG84
names: Similarity
messages: Belongs to the peptidase M14 family.

9646:RGS2
gene id: 9646:RGS2
uniprot id: D2HM07
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: nucleolus

9646:NUP58
gene id: 9646:NUP58
uniprot id: A0A7N5K8R2
uniprot id: G1M6P8
names: Subcellular Location Annotation
messages: nuclear pore complex

9646:TMEM170A
gene id: 9646:TMEM170A
uniprot id: D2HY24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9646:MON1B
gene id: 9646:MON1B
uniprot id: G1M884
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9646:LOC100473467
gene id: 9646:LOC100473467
uniprot id: D2HU15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:JPH3
gene id: 9646:JPH3
uniprot id: G1MIV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9646:RPS26
gene id: 9646:RPS26
uniprot id: D3YBZ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9646:CAMK1G
gene id: 9646:CAMK1G
uniprot id: D2HIK0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:RNF182
gene id: 9646:RNF182
uniprot id: D2H788
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA.
messages: Interacts with ATP6V0C.
messages: Membrane
messages: The RING-type zinc finger domain is required for E3 ligase activity.

9646:RTCB
gene id: 9646:RTCB
uniprot id: D2HHB0
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

9646:XPO5
gene id: 9646:XPO5
uniprot id: A0A7N5K2C4
uniprot id: G1M0I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9646:TMEM8B
gene id: 9646:TMEM8B
uniprot id: G1LTQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9646:LOC100483224
gene id: 9646:LOC100483224
uniprot id: A0A7N5P996
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9646:EDC4
gene id: 9646:EDC4
uniprot id: G1MGS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9646:LOC100477677
gene id: 9646:LOC100477677
uniprot id: D2HY23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9646:GRIA2
gene id: 9646:GRIA2
uniprot id: A0A7N5P606
uniprot id: D2HBM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9646:BTC
gene id: 9646:BTC
uniprot id: G1M715
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:PUS7L
gene id: 9646:PUS7L
uniprot id: A0A7N5JWJ6
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9646:GDE1
gene id: 9646:GDE1
uniprot id: A0A7N5JK04
uniprot id: D2HYW9
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9646:MED18
gene id: 9646:MED18
uniprot id: D2GWK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9646:PPIB
gene id: 9646:PPIB
uniprot id: D2GYR4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9646:LOC100484571
gene id: 9646:LOC100484571
uniprot id: D2I6W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:NSDHL
gene id: 9646:NSDHL
uniprot id: G1L0G9
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9646:PIGC
gene id: 9646:PIGC
uniprot id: D2H5H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9646:USP51
gene id: 9646:USP51
uniprot id: D2I7W5
uniprot id: G1MLV1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9646:YWHAZ
gene id: 9646:YWHAZ
uniprot id: A0A7N5KS25
names: Similarity
messages: Belongs to the 14-3-3 family.

9646:POMK
gene id: 9646:POMK
uniprot id: D2H969
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.

9646:FDFT1
gene id: 9646:FDFT1
uniprot id: D2HMR1
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9646:GRIA3
gene id: 9646:GRIA3
uniprot id: A0A7N5JXS9
uniprot id: G1M8F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9646:RAP2C
gene id: 9646:RAP2C
uniprot id: D2HKT8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9646:PAQR4
gene id: 9646:PAQR4
uniprot id: D2I6Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9646:DHRS9
gene id: 9646:DHRS9
uniprot id: D2H4D4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:EVA1B
gene id: 9646:EVA1B
uniprot id: D2HRM7
names: Similarity
messages: Belongs to the EVA1 family.

9646:FRAS1
gene id: 9646:FRAS1
uniprot id: G1LG13
names: Similarity
messages: Belongs to the FRAS1 family.

9646:WNT7A
gene id: 9646:WNT7A
uniprot id: A0A7N5K0U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9646:PRKAA1
gene id: 9646:PRKAA1
uniprot id: A0A7N5P827
uniprot id: D2HJX7
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9646:SLC15A2
gene id: 9646:SLC15A2
uniprot id: D2HWU1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9646:RAD17
gene id: 9646:RAD17
uniprot id: G1L956
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

9646:SIX1
gene id: 9646:SIX1
uniprot id: D2GVS4
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100470170
gene id: 9646:LOC100470170
uniprot id: A0A7N5P3N5
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9646:GAPDH
gene id: 9646:GAPDH
uniprot id: D6BQW4
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9646:LOC105235968
gene id: 9646:LOC105235968
uniprot id: A0A7N5JNL3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:UPP1
gene id: 9646:UPP1
uniprot id: G1LDM5
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

9646:SLC17A2
gene id: 9646:SLC17A2
uniprot id: G1MBR8
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100466302
gene id: 9646:LOC100466302
uniprot id: G1M477
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9646:CSF1
gene id: 9646:CSF1
uniprot id: G1LEP2
names: Function
names: Subunit
messages: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
messages: Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R.

9646:YIPF7
gene id: 9646:YIPF7
uniprot id: G1MCC5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:SEMA5A
gene id: 9646:SEMA5A
uniprot id: D2H9X1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:DDX31
gene id: 9646:DDX31
uniprot id: G1LBU3
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9646:TYK2
gene id: 9646:TYK2
uniprot id: D2HGY7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9646:SLC27A2
gene id: 9646:SLC27A2
uniprot id: G1LQK5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9646:LAMTOR3
gene id: 9646:LAMTOR3
uniprot id: G1L2D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9646:ABHD2
gene id: 9646:ABHD2
uniprot id: D2HCD9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9646:ACYP2
gene id: 9646:ACYP2
uniprot id: A0A7N5KC83
names: Similarity
messages: Belongs to the acylphosphatase family.

9646:SERP1
gene id: 9646:SERP1
uniprot id: A0A7N5KPS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9646:ADCY8
gene id: 9646:ADCY8
uniprot id: D2H7A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9646:SH3BP5L
gene id: 9646:SH3BP5L
uniprot id: D2I5Y9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9646:UST
gene id: 9646:UST
uniprot id: A0A7N5K928
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:LOC100473285
gene id: 9646:LOC100473285
uniprot id: D2HLW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9646:CDIP1
gene id: 9646:CDIP1
uniprot id: G1L4Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9646:PFN4
gene id: 9646:PFN4
uniprot id: G1L7Q0
names: Similarity
messages: Belongs to the profilin family.

9646:CDCA7L
gene id: 9646:CDCA7L
uniprot id: G1LBH3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:LOC100471709
gene id: 9646:LOC100471709
uniprot id: D2HU41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:MARCHF4
gene id: 9646:MARCHF4
uniprot id: D2GXF0
names: Subcellular Location Annotation
messages: Membrane

9646:PRPF3
gene id: 9646:PRPF3
uniprot id: D2HBU4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9646:GAPVD1
gene id: 9646:GAPVD1
uniprot id: G1MDX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

9646:C14H18orf25
gene id: 9646:C14H18orf25
uniprot id: D2H8K0
names: Subcellular Location Annotation
messages: Nucleus

9646:PDE6B
gene id: 9646:PDE6B
uniprot id: G1ME74
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9646:AP2M1
gene id: 9646:AP2M1
uniprot id: A0A7N5KIG7
uniprot id: D2H2A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9646:LOC100474594
gene id: 9646:LOC100474594
uniprot id: G1MPC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:IMMP2L
gene id: 9646:IMMP2L
uniprot id: G1LGY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

9646:MB
gene id: 9646:MB
uniprot id: D2HSS2
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9646:LOC100464636
gene id: 9646:LOC100464636
uniprot id: G1L591
names: Similarity
messages: Belongs to the MHC class II family.

9646:LOC100484588
gene id: 9646:LOC100484588
uniprot id: A0A7N5K9E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9646:RAB27B
gene id: 9646:RAB27B
uniprot id: D2GZT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9646:EPC1
gene id: 9646:EPC1
uniprot id: G1LUZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9646:VPS45
gene id: 9646:VPS45
uniprot id: D2HBV3
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9646:SGTA
gene id: 9646:SGTA
uniprot id: D2HMF6
names: Similarity
messages: Belongs to the SGT family.

9646:ADCYAP1R1
gene id: 9646:ADCYAP1R1
uniprot id: G1LK41
names: Subcellular Location Annotation
messages: Membrane

9646:NDUFA2
gene id: 9646:NDUFA2
uniprot id: D2GUN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9646:ST8SIA1
gene id: 9646:ST8SIA1
uniprot id: D2H1B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9646:STAR
gene id: 9646:STAR
uniprot id: G1LXA7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9646:UTP3
gene id: 9646:UTP3
uniprot id: D2HC96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAS10 family.
messages: nucleolus

9646:CCL20
gene id: 9646:CCL20
uniprot id: A0A7N5P516
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9646:LOC100480515
gene id: 9646:LOC100480515
uniprot id: G1M0C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9646:LOC100483542
gene id: 9646:LOC100483542
uniprot id: D2HWJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:EHD4
gene id: 9646:EHD4
uniprot id: D2GW79
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9646:PARP9
gene id: 9646:PARP9
uniprot id: G1M751
names: Similarity
messages: Belongs to the ARTD/PARP family.

9646:LOC100466450
gene id: 9646:LOC100466450
uniprot id: G1M215
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9646:PDK2
gene id: 9646:PDK2
uniprot id: D2HMX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9646:LOC100468093
gene id: 9646:LOC100468093
uniprot id: D2HI13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:RPL31
gene id: 9646:RPL31
uniprot id: F2X276
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9646:CAVIN2
gene id: 9646:CAVIN2
uniprot id: D2H886
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9646:LOC100477414
gene id: 9646:LOC100477414
uniprot id: D2HRD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9646:RPL35A
gene id: 9646:RPL35A
uniprot id: F2X282
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9646:DCTD
gene id: 9646:DCTD
uniprot id: A0A7N5JJN9
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9646:PHTF1
gene id: 9646:PHTF1
uniprot id: G1L9J0
names: Subcellular Location Annotation
messages: Membrane

9646:ADAMTS4
gene id: 9646:ADAMTS4
uniprot id: D2I0T1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9646:ROPN1
gene id: 9646:ROPN1
uniprot id: G1LN02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

9646:SEPHS1
gene id: 9646:SEPHS1
uniprot id: A0A7N5PA83
uniprot id: D2HSW2
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9646:ARL1
gene id: 9646:ARL1
uniprot id: G1MDF4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9646:BCL2L1
gene id: 9646:BCL2L1
uniprot id: D2H915
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9646:CTNNBL1
gene id: 9646:CTNNBL1
uniprot id: A0A7N5JWS0
names: Subcellular Location Annotation
messages: Nucleus

9646:HIGD1A
gene id: 9646:HIGD1A
uniprot id: G1M168
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9646:LYZL4
gene id: 9646:LYZL4
uniprot id: G1L403
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9646:LOC100464807
gene id: 9646:LOC100464807
uniprot id: D2H0Y5
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100464774
gene id: 9646:LOC100464774
uniprot id: G1MNT7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GPR87
gene id: 9646:GPR87
uniprot id: G1LQH9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:P2RY13
gene id: 9646:P2RY13
uniprot id: G1ML91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:PSMC3
gene id: 9646:PSMC3
uniprot id: D2HHK5
names: Similarity
messages: Belongs to the AAA ATPase family.

9646:APH1A
gene id: 9646:APH1A
uniprot id: A0A7N5JKI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9646:PARP2
gene id: 9646:PARP2
uniprot id: G1LG33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9646:DIS3L2
gene id: 9646:DIS3L2
uniprot id: G1MDU8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cytoplasm
messages: P-body
messages: Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.

9646:PAH
gene id: 9646:PAH
uniprot id: G1LIM6
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9646:GJC1
gene id: 9646:GJC1
uniprot id: D2HCW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9646:FGF23
gene id: 9646:FGF23
uniprot id: D2HEJ9
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9646:FCER1G
gene id: 9646:FCER1G
uniprot id: G1MAD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9646:LDHB
gene id: 9646:LDHB
uniprot id: D2I1F1
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9646:TCTA
gene id: 9646:TCTA
uniprot id: G1M1M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

9646:IRF5
gene id: 9646:IRF5
uniprot id: G1LES8
names: Subcellular Location Annotation
messages: Nucleus

9646:APC
gene id: 9646:APC
uniprot id: A0A7N5KE23
uniprot id: A0A7N5P5W0
uniprot id: D2HBD2
uniprot id: G1M1X1
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9646:COG4
gene id: 9646:COG4
uniprot id: D2HFV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

9646:LOC100463545
gene id: 9646:LOC100463545
uniprot id: G1L911
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9646:PKNOX1
gene id: 9646:PKNOX1
uniprot id: G1L4U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9646:HTR5A
gene id: 9646:HTR5A
uniprot id: D2HTZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:STMN3
gene id: 9646:STMN3
uniprot id: G1L4E8
names: Similarity
messages: Belongs to the stathmin family.

9646:GTF2E2
gene id: 9646:GTF2E2
uniprot id: D2HFK1
names: Function
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

9646:MAS1
gene id: 9646:MAS1
uniprot id: D2HS51
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:MRPL18
gene id: 9646:MRPL18
uniprot id: G1MA67
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

9646:FAM13B
gene id: 9646:FAM13B
uniprot id: A0A7N5JDA6
uniprot id: D2HK87
names: Similarity
messages: Belongs to the FAM13 family.

9646:RAX2
gene id: 9646:RAX2
uniprot id: D2HMH9
names: Subcellular Location Annotation
messages: Nucleus

9646:VPS25
gene id: 9646:VPS25
uniprot id: D2HIU8
names: Similarity
messages: Belongs to the VPS25 family.

9646:LAPTM4A
gene id: 9646:LAPTM4A
uniprot id: G1L7S3
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9646:POSTN
gene id: 9646:POSTN
uniprot id: A0A7N5JP95
uniprot id: A0A7N5JS45
uniprot id: A0A7N5K6W1
uniprot id: A0A7N5K7W7
uniprot id: G1KZU2
names: Subcellular Location Annotation
messages: extracellular matrix

9646:ERBB4
gene id: 9646:ERBB4
uniprot id: G1LLD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9646:STX5
gene id: 9646:STX5
uniprot id: D2HS71
names: Similarity
messages: Belongs to the syntaxin family.

9646:EHF
gene id: 9646:EHF
uniprot id: D2HF02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:RIN1
gene id: 9646:RIN1
uniprot id: D2H4M3
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9646:LOC100477047
gene id: 9646:LOC100477047
uniprot id: A0A7N5KGG3
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9646:CYLD
gene id: 9646:CYLD
uniprot id: A0A7N5JFE2
uniprot id: D2GYQ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9646:GHR
gene id: 9646:GHR
uniprot id: Q95JF2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Cell membrane
messages: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.
messages: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.
messages: On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).
messages: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity).
messages: Secreted
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
messages: The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.

9646:CPT2
gene id: 9646:CPT2
uniprot id: D2H2F0
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9646:KCNK1
gene id: 9646:KCNK1
uniprot id: G1LL10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

9646:NEURL2
gene id: 9646:NEURL2
uniprot id: D2HZ10
names: Subcellular Location Annotation
messages: Cytoplasm

9646:RBM42
gene id: 9646:RBM42
uniprot id: D2HFS1
names: Similarity
messages: Belongs to the RRM RBM42 family.

9646:POLR2A
gene id: 9646:POLR2A
uniprot id: G1MCZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9646:FGD6
gene id: 9646:FGD6
uniprot id: G1L649
names: Subcellular Location Annotation
messages: cytoskeleton

9646:EIF2A
gene id: 9646:EIF2A
uniprot id: G1LVF9
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9646:MYF5
gene id: 9646:MYF5
uniprot id: D2H509
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9646:DEFB123
gene id: 9646:DEFB123
uniprot id: A0A7N5JLX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9646:PIK3R1
gene id: 9646:PIK3R1
uniprot id: G1L8J9
uniprot id: G1L8K7
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9646:CXHXorf56
gene id: 9646:CXHXorf56
uniprot id: G1KZW0
names: Similarity
messages: Belongs to the STEEP1 family.

9646:AQP7
gene id: 9646:AQP7
uniprot id: G1LLN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9646:NUDT7
gene id: 9646:NUDT7
uniprot id: A0A7N5K815
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

9646:EXOSC2
gene id: 9646:EXOSC2
uniprot id: G1MCS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9646:CTBP2
gene id: 9646:CTBP2
uniprot id: G1LBU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9646:TSPAN7
gene id: 9646:TSPAN7
uniprot id: G1LKL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9646:GK2
gene id: 9646:GK2
uniprot id: D2GUG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9646:DUSP6
gene id: 9646:DUSP6
uniprot id: D2I047
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9646:LOC100468151
gene id: 9646:LOC100468151
uniprot id: G1MPM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:LOC100473112
gene id: 9646:LOC100473112
uniprot id: D2HAL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ASIC1
gene id: 9646:ASIC1
uniprot id: A0A7N5JD63
uniprot id: A0A7N5KI57
names: Subcellular Location Annotation
messages: Membrane

9646:PSMD2
gene id: 9646:PSMD2
uniprot id: G1MFJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9646:PADI3
gene id: 9646:PADI3
uniprot id: D2HNM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Cytoplasm

9646:ADPRH
gene id: 9646:ADPRH
uniprot id: D2H196
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9646:SEPTIN4
gene id: 9646:SEPTIN4
uniprot id: A0A7N5JRK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9646:SULF1
gene id: 9646:SULF1
uniprot id: A0A7N5KLM5
uniprot id: G1LHX9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9646:TPM4
gene id: 9646:TPM4
uniprot id: D2GUY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9646:SPI1
gene id: 9646:SPI1
uniprot id: A0A7N5KKA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:SLC9A8
gene id: 9646:SLC9A8
uniprot id: G1M4J2
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

9646:SERPINI2
gene id: 9646:SERPINI2
uniprot id: G1L620
names: Similarity
messages: Belongs to the serpin family.

9646:B3GNT3
gene id: 9646:B3GNT3
uniprot id: A0A7N5P152
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:LOC100476837
gene id: 9646:LOC100476837
uniprot id: D2HQT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9646:RBM46
gene id: 9646:RBM46
uniprot id: A0A7N5JYR3
names: Subcellular Location Annotation
messages: Cytoplasm

9646:MYOC
gene id: 9646:MYOC
uniprot id: G1MEZ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:ZDHHC24
gene id: 9646:ZDHHC24
uniprot id: D2HYA8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9646:CACNG2
gene id: 9646:CACNG2
uniprot id: D2GZG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

9646:ZDHHC21
gene id: 9646:ZDHHC21
uniprot id: D2H2X8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9646:LOC100473459
gene id: 9646:LOC100473459
uniprot id: D2HQ18
names: Similarity
messages: Belongs to the TACO1 family.

9646:CALHM2
gene id: 9646:CALHM2
uniprot id: D2GXY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9646:NGLY1
gene id: 9646:NGLY1
uniprot id: D2HUZ7
uniprot id: G1L186
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.

9646:FADS2
gene id: 9646:FADS2
uniprot id: D2HUF7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9646:CMC2
gene id: 9646:CMC2
uniprot id: D2H7I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9646:LIN54
gene id: 9646:LIN54
uniprot id: D2GUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9646:AGO3
gene id: 9646:AGO3
uniprot id: G1L1D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9646:GOSR2
gene id: 9646:GOSR2
uniprot id: A0A7N5JMS0
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100476181
gene id: 9646:LOC100476181
uniprot id: D2I6F9
names: Similarity
messages: Belongs to the BEX family.

9646:HMGA1
gene id: 9646:HMGA1
uniprot id: G1L2J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9646:IFIH1
gene id: 9646:IFIH1
uniprot id: D2HQW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9646:ZYG11B
gene id: 9646:ZYG11B
uniprot id: A0A7N5JJQ1
names: Similarity
messages: Belongs to the zyg-11 family.

9646:ATP2A1
gene id: 9646:ATP2A1
uniprot id: G1MAX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9646:LOC100470259
gene id: 9646:LOC100470259
uniprot id: G1L0Y9
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9646:PALMD
gene id: 9646:PALMD
uniprot id: G1LRD3
names: Similarity
messages: Belongs to the paralemmin family.

9646:APH1B
gene id: 9646:APH1B
uniprot id: D2GYQ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9646:PTGDR
gene id: 9646:PTGDR
uniprot id: D2HV42
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:ANXA3
gene id: 9646:ANXA3
uniprot id: A0A7N5JJR0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9646:CHRM1
gene id: 9646:CHRM1
uniprot id: D2HS68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9646:SSTR4
gene id: 9646:SSTR4
uniprot id: D2HSG4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:MRPL40
gene id: 9646:MRPL40
uniprot id: G1LY56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9646:IARS1
gene id: 9646:IARS1
uniprot id: G1M4C5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9646:ARID5B
gene id: 9646:ARID5B
uniprot id: G1LAA8
names: Similarity
messages: Belongs to the ARID5B family.

9646:POGLUT2
gene id: 9646:POGLUT2
uniprot id: G1MDJ6
names: Similarity
messages: Belongs to the KDELC family.

9646:VPS13B
gene id: 9646:VPS13B
uniprot id: D2GY40
names: Similarity
messages: Belongs to the VPS13 family.

9646:RSRP1
gene id: 9646:RSRP1
uniprot id: D2GWE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RSRP family.
messages: Nucleus
messages: Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6.

9646:SSH2
gene id: 9646:SSH2
uniprot id: A0A7N5K8H3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9646:PGAM1
gene id: 9646:PGAM1
uniprot id: D2H5L1
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9646:IMP4
gene id: 9646:IMP4
uniprot id: G1L865
names: Subcellular Location Annotation
messages: nucleolus

9646:CPA3
gene id: 9646:CPA3
uniprot id: D2HWE1
names: Similarity
messages: Belongs to the peptidase M14 family.

9646:INIP
gene id: 9646:INIP
uniprot id: G1LJU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9646:TASP1
gene id: 9646:TASP1
uniprot id: D2H9J1
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9646:SMAD9
gene id: 9646:SMAD9
uniprot id: D2I637
uniprot id: G1M7B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9646:MFF
gene id: 9646:MFF
uniprot id: A0A7N5K0E9
uniprot id: A0A7N5K5I7
uniprot id: A0A7N5K988
uniprot id: A0A7N5P6F5
uniprot id: A0A7N5P6G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
messages: synaptic vesicle

9646:GABARAP
gene id: 9646:GABARAP
uniprot id: G1MDM5
names: Similarity
messages: Belongs to the ATG8 family.

9646:PCNX1
gene id: 9646:PCNX1
uniprot id: D2HVR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9646:LOC100474509
gene id: 9646:LOC100474509
uniprot id: A0A7N5K618
names: Similarity
messages: Belongs to the LCE family.

9646:DDI1
gene id: 9646:DDI1
uniprot id: G1MLG4
names: Similarity
messages: Belongs to the DDI1 family.

9646:MRGPRF
gene id: 9646:MRGPRF
uniprot id: G1L491
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:FICD
gene id: 9646:FICD
uniprot id: A0A7N5JYT5
names: Similarity
messages: Belongs to the fic family.

9646:FAM110D
gene id: 9646:FAM110D
uniprot id: D2GWG1
names: Similarity
messages: Belongs to the FAM110 family.

9646:TMCC1
gene id: 9646:TMCC1
uniprot id: G1LCI4
names: Similarity
messages: Belongs to the TEX28 family.

9646:AVIL
gene id: 9646:AVIL
uniprot id: A0A7N5K0I6
names: Similarity
messages: Belongs to the villin/gelsolin family.

9646:ITPR1
gene id: 9646:ITPR1
uniprot id: G1MC67
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9646:LOC100467204
gene id: 9646:LOC100467204
uniprot id: D2I675
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TRAM1
gene id: 9646:TRAM1
uniprot id: G1LID0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9646:NR1H3
gene id: 9646:NR1H3
uniprot id: G1LL75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9646:GABRA4
gene id: 9646:GABRA4
uniprot id: D2H5P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:NUDT5
gene id: 9646:NUDT5
uniprot id: G1LCQ7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9646:TRIM3
gene id: 9646:TRIM3
uniprot id: D2HR64
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9646:MRPL49
gene id: 9646:MRPL49
uniprot id: G1MH32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

9646:CAMKMT
gene id: 9646:CAMKMT
uniprot id: G1LH95
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:PSMB1
gene id: 9646:PSMB1
uniprot id: D2HRT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9646:LY6G5C
gene id: 9646:LY6G5C
uniprot id: G1LRP9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms oligomers.
messages: May have a role in hematopoietic cell differentiation.
messages: Secreted

9646:LPCAT1
gene id: 9646:LPCAT1
uniprot id: G1LWM6
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9646:GPAT4
gene id: 9646:GPAT4
uniprot id: G1L7J4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9646:GPR132
gene id: 9646:GPR132
uniprot id: A0A7N5JKX5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:GABARAPL1
gene id: 9646:GABARAPL1
uniprot id: A0A7N5K2N8
names: Similarity
messages: Belongs to the ATG8 family.

9646:NR4A2
gene id: 9646:NR4A2
uniprot id: A0A7N5KIE1
uniprot id: D2HUI7
uniprot id: G1LTC3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9646:XPR1
gene id: 9646:XPR1
uniprot id: G1L826
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

9646:NOSIP
gene id: 9646:NOSIP
uniprot id: D2H7V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Nucleus

9646:RPL37
gene id: 9646:RPL37
uniprot id: G1MA88
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9646:MAL
gene id: 9646:MAL
uniprot id: A0A7N5JLI2
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100478439
gene id: 9646:LOC100478439
uniprot id: G1MKQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9646:TNFAIP6
gene id: 9646:TNFAIP6
uniprot id: D2HLK3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:SUOX
gene id: 9646:SUOX
uniprot id: D2H338
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
messages: Mitochondrion intermembrane space

9646:ESF1
gene id: 9646:ESF1
uniprot id: D2H9J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

9646:PSKH1
gene id: 9646:PSKH1
uniprot id: D2H9G2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:BMP1
gene id: 9646:BMP1
uniprot id: D2H047
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:RHAG
gene id: 9646:RHAG
uniprot id: A0A7N5JF40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9646:CDC45
gene id: 9646:CDC45
uniprot id: G1LYC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9646:STARD13
gene id: 9646:STARD13
uniprot id: A0A7N5K1T9
uniprot id: G1LRW1
names: Subcellular Location Annotation
messages: Cytoplasm

9646:TSEN2
gene id: 9646:TSEN2
uniprot id: G1LDP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9646:CYSLTR2
gene id: 9646:CYSLTR2
uniprot id: D2HB76
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:SIN3A
gene id: 9646:SIN3A
uniprot id: D2HRJ6
names: Subcellular Location Annotation
messages: Nucleus

9646:F7
gene id: 9646:F7
uniprot id: A0A7N5P4B4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:LOC100470335
gene id: 9646:LOC100470335
uniprot id: D2H4W7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9646:ABITRAM
gene id: 9646:ABITRAM
uniprot id: A0A7N5K3K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9646:RNF146
gene id: 9646:RNF146
uniprot id: G1MPB0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9646:VEGFD
gene id: 9646:VEGFD
uniprot id: G1MFE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9646:CDK12
gene id: 9646:CDK12
uniprot id: D2H526
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors (By similarity).
messages: Interacts with CCNL1 and CCNL2.
messages: Nucleus
messages: Nucleus speckle
messages: Phosphorylation at Thr-894 increases kinase activity.

9646:ACOT13
gene id: 9646:ACOT13
uniprot id: G1LUJ4
names: Similarity
messages: Belongs to the thioesterase PaaI family.

9646:IRF2BP1
gene id: 9646:IRF2BP1
uniprot id: D2I067
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9646:PPM1G
gene id: 9646:PPM1G
uniprot id: D2GXL3
names: Similarity
messages: Belongs to the PP2C family.

9646:NUP35
gene id: 9646:NUP35
uniprot id: G1L300
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9646:CKMT2
gene id: 9646:CKMT2
uniprot id: D2H3P2
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9646:DHCR7
gene id: 9646:DHCR7
uniprot id: G1LLR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9646:FABP12
gene id: 9646:FABP12
uniprot id: G1M7L3
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9646:PGAP2
gene id: 9646:PGAP2
uniprot id: G1LWV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PGAP2 family.
messages: Interacts with PGAP2IP.
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

9646:HAUS3
gene id: 9646:HAUS3
uniprot id: D2H4G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

9646:MRPS18C
gene id: 9646:MRPS18C
uniprot id: D2GUE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9646:LOC100475627
gene id: 9646:LOC100475627
uniprot id: D2H4U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9646:SFXN1
gene id: 9646:SFXN1
uniprot id: D2HHS9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9646:CASC3
gene id: 9646:CASC3
uniprot id: A0A7N5KPL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

9646:PFDN2
gene id: 9646:PFDN2
uniprot id: G1MAQ8
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9646:FARSB
gene id: 9646:FARSB
uniprot id: G1LHG8
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

9646:GPR101
gene id: 9646:GPR101
uniprot id: D2HD89
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:FOXR2
gene id: 9646:FOXR2
uniprot id: D2I5Q6
names: Subcellular Location Annotation
messages: Nucleus

9646:DIPK1A
gene id: 9646:DIPK1A
uniprot id: A0A7N5KI79
uniprot id: A0A7N5KPR9
names: Similarity
messages: Belongs to the DIPK family.

9646:LOC100477439
gene id: 9646:LOC100477439
uniprot id: D2I5X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ATG4C
gene id: 9646:ATG4C
uniprot id: A0A7N5P9H6
uniprot id: D2H7H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9646:HLCS
gene id: 9646:HLCS
uniprot id: A0A7N5JPX5
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9646:PDK4
gene id: 9646:PDK4
uniprot id: G1LUV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9646:CD320
gene id: 9646:CD320
uniprot id: A0A7N5JFR7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:TYW3
gene id: 9646:TYW3
uniprot id: D2H5D6
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9646:LBH
gene id: 9646:LBH
uniprot id: A0A7N5JJZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9646:LOC100477107
gene id: 9646:LOC100477107
uniprot id: A0A7N5JD01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ZDHHC6
gene id: 9646:ZDHHC6
uniprot id: D2GX33
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9646:C8H1orf74
gene id: 9646:C8H1orf74
uniprot id: D2HIJ5
names: Similarity
messages: Belongs to the UPF0739 family.

9646:CEBPG
gene id: 9646:CEBPG
uniprot id: D2I446
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

9646:IL1A
gene id: 9646:IL1A
uniprot id: G1LW58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
messages: Cytoplasm
messages: Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane.
messages: Nucleus
messages: Secreted

9646:CFAP45
gene id: 9646:CFAP45
uniprot id: A0A7N5KBE7
uniprot id: G1LSF3
names: Similarity
messages: Belongs to the CFAP45 family.

9646:MGST2
gene id: 9646:MGST2
uniprot id: G1LWS4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:PIGS
gene id: 9646:PIGS
uniprot id: D2GU34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:NLK
gene id: 9646:NLK
uniprot id: G1LEU7
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9646:FLT1
gene id: 9646:FLT1
uniprot id: A0A7N5JSS2
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

9646:TYRP1
gene id: 9646:TYRP1
uniprot id: D2HQD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9646:SELP
gene id: 9646:SELP
uniprot id: A0A7N5JJL0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:HOMER1
gene id: 9646:HOMER1
uniprot id: G1MAU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9646:CSAD
gene id: 9646:CSAD
uniprot id: G1M0J6
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9646:RPL22
gene id: 9646:RPL22
uniprot id: F2X262
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9646:ORC4
gene id: 9646:ORC4
uniprot id: G1M471
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9646:LHX6
gene id: 9646:LHX6
uniprot id: G1L1S7
names: Subcellular Location Annotation
messages: Nucleus

9646:DTWD2
gene id: 9646:DTWD2
uniprot id: D2H1R2
names: Similarity
messages: Belongs to the TDD superfamily. DTWD2 family.

9646:MAP2K1
gene id: 9646:MAP2K1
uniprot id: D2GYT9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:CSNK1A1
gene id: 9646:CSNK1A1
uniprot id: A0A7N5JCS0
uniprot id: D2H8N0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:TLCD3A
gene id: 9646:TLCD3A
uniprot id: A0A7N5KH89
uniprot id: A0A7N5KNC6
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100465089
gene id: 9646:LOC100465089
uniprot id: A0A7N5JGS7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:ANO3
gene id: 9646:ANO3
uniprot id: A0A7N5KMX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9646:KDM5C
gene id: 9646:KDM5C
uniprot id: D2HVV1
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

9646:AIFM1
gene id: 9646:AIFM1
uniprot id: A0A7N5P6E4
uniprot id: G1M8T5
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

9646:LOC100469295
gene id: 9646:LOC100469295
uniprot id: G1LXW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9646:LPXN
gene id: 9646:LPXN
uniprot id: A0A7N5KEY6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.
messages: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).
messages: focal adhesion
messages: perinuclear region
messages: podosome

9646:LOC100468212
gene id: 9646:LOC100468212
uniprot id: G1MN09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TNF
gene id: 9646:TNF
uniprot id: D2I4B3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.

9646:LOC100478403
gene id: 9646:LOC100478403
uniprot id: D2HAL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:KPNA2
gene id: 9646:KPNA2
uniprot id: D2HQA5
names: Similarity
messages: Belongs to the importin alpha family.

9646:FAIM2
gene id: 9646:FAIM2
uniprot id: A0A7N5JP93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9646:KCNK5
gene id: 9646:KCNK5
uniprot id: D2HV56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9646:LOC100466952
gene id: 9646:LOC100466952
uniprot id: G1LIW0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9646:LOC100472940
gene id: 9646:LOC100472940
uniprot id: D2HI70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC109490896
gene id: 9646:LOC109490896
uniprot id: G1MJV5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:FAM229B
gene id: 9646:FAM229B
uniprot id: D2H643
names: Similarity
messages: Belongs to the FAM229 family.

9646:IDH1
gene id: 9646:IDH1
uniprot id: D2H8H7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Homodimer.

9646:KCNJ12
gene id: 9646:KCNJ12
uniprot id: D2I1B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
messages: Cell membrane
messages: Membrane

9646:MYADM
gene id: 9646:MYADM
uniprot id: D2HYP7
uniprot id: G1MM34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9646:ACKR3
gene id: 9646:ACKR3
uniprot id: D2I542
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:ANXA11
gene id: 9646:ANXA11
uniprot id: G1M2V2
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9646:NAGA
gene id: 9646:NAGA
uniprot id: G1LS60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9646:ZNF24
gene id: 9646:ZNF24
uniprot id: A0A7N5JWJ9
names: Subcellular Location Annotation
messages: Nucleus

9646:PLA2G2F
gene id: 9646:PLA2G2F
uniprot id: A0A7N5P9S1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9646:NR1H4
gene id: 9646:NR1H4
uniprot id: A0A7N5KIP8
uniprot id: D2I052
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9646:TBP
gene id: 9646:TBP
uniprot id: G1MFA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9646:NQO2
gene id: 9646:NQO2
uniprot id: G1M738
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9646:CCDC25
gene id: 9646:CCDC25
uniprot id: A0A7N5JQQ3
uniprot id: A0A7N5JUZ0
uniprot id: G1KZU7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9646:DDX1
gene id: 9646:DDX1
uniprot id: G1L2R9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule
messages: RNA helicase.
messages: The helicase domain is involved in the stimulation of RELA transcriptional activity.

9646:CLDN14
gene id: 9646:CLDN14
uniprot id: D2H5U1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9646:ATP5F1C
gene id: 9646:ATP5F1C
uniprot id: G1LTN3
uniprot id: G1LTN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9646:LOC100472222
gene id: 9646:LOC100472222
uniprot id: A0A7N5K287
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC100483213
gene id: 9646:LOC100483213
uniprot id: A0A7N5KRR2
names: Similarity
messages: Belongs to the peptidase M16 family.

9646:ARL11
gene id: 9646:ARL11
uniprot id: G1L7N9
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9646:SCAMP1
gene id: 9646:SCAMP1
uniprot id: A0A7N5P947
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9646:IL2RG
gene id: 9646:IL2RG
uniprot id: A0A7N5P498
names: Subcellular Location Annotation
messages: Membrane

9646:SASS6
gene id: 9646:SASS6
uniprot id: A0A7N5JDB5
names: Subcellular Location Annotation
messages: centrosome

9646:APOH
gene id: 9646:APOH
uniprot id: G1LZF5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:LOC100470966
gene id: 9646:LOC100470966
uniprot id: D2HU37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:PJVK
gene id: 9646:PJVK
uniprot id: D2HAF3
names: Similarity
messages: Belongs to the gasdermin family.

9646:ADGRB3
gene id: 9646:ADGRB3
uniprot id: G1MA43
names: Subcellular Location Annotation
messages: Membrane

9646:GALNT15
gene id: 9646:GALNT15
uniprot id: G1LR00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9646:ENSA
gene id: 9646:ENSA
uniprot id: G1L3J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9646:NEFM
gene id: 9646:NEFM
uniprot id: D2GZ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon

9646:CCT5
gene id: 9646:CCT5
uniprot id: D2H9W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9646:LOC100479155
gene id: 9646:LOC100479155
uniprot id: A0A7N5P5T2
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9646:TBRG1
gene id: 9646:TBRG1
uniprot id: D2HNJ8
names: Subcellular Location Annotation
messages: Nucleus

9646:C2H2orf76
gene id: 9646:C2H2orf76
uniprot id: D2H746
names: Similarity
messages: Belongs to the UPF0538 family.

9646:TFPI2
gene id: 9646:TFPI2
uniprot id: G1MHA9
names: Subcellular Location Annotation
messages: Secreted

9646:MTIF3
gene id: 9646:MTIF3
uniprot id: D2HWR1
names: Similarity
messages: Belongs to the IF-3 family.

9646:LOC100483541
gene id: 9646:LOC100483541
uniprot id: G1L1I6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:AP4S1
gene id: 9646:AP4S1
uniprot id: A0A7N5JMB4
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9646:RNF185
gene id: 9646:RNF185
uniprot id: D2H206
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

9646:SKIL
gene id: 9646:SKIL
uniprot id: G1LDF9
names: Similarity
messages: Belongs to the SKI family.

9646:AP3M1
gene id: 9646:AP3M1
uniprot id: D2HEE3
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

9646:UBIAD1
gene id: 9646:UBIAD1
uniprot id: D2HKB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiA prenyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with HMGCR and SOAT1.
messages: Mitochondrion membrane
messages: Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.

9646:LOC100466240
gene id: 9646:LOC100466240
uniprot id: G1L4K0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9646:IFNAR1
gene id: 9646:IFNAR1
uniprot id: G1M8V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9646:MAPKAP1
gene id: 9646:MAPKAP1
uniprot id: A0A7N5P0L3
uniprot id: D2H3X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIN1 family.
messages: Cytoplasmic vesicle

9646:CLDN25
gene id: 9646:CLDN25
uniprot id: G1MM61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9646:SLCO1C1
gene id: 9646:SLCO1C1
uniprot id: G1L2G8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:MPP3
gene id: 9646:MPP3
uniprot id: G1MJ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane

9646:SLC25A41
gene id: 9646:SLC25A41
uniprot id: D2HY76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:TOB2
gene id: 9646:TOB2
uniprot id: D2HUX3
names: Similarity
messages: Belongs to the BTG family.

9646:S100A16
gene id: 9646:S100A16
uniprot id: D2HJR2
names: Similarity
messages: Belongs to the S-100 family.

9646:TPRG1
gene id: 9646:TPRG1
uniprot id: D2H063
names: Similarity
messages: Belongs to the TPRG1 family.

9646:DEFB113
gene id: 9646:DEFB113
uniprot id: G1LQ68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9646:ALG14
gene id: 9646:ALG14
uniprot id: G1ME58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

9646:BYSL
gene id: 9646:BYSL
uniprot id: D2GZE9
names: Similarity
messages: Belongs to the bystin family.

9646:LOC100465603
gene id: 9646:LOC100465603
uniprot id: A0A7N5JIH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:BDH1
gene id: 9646:BDH1
uniprot id: G1LS82
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:SLC12A5
gene id: 9646:SLC12A5
uniprot id: A0A7N5P661
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9646:LOC100468005
gene id: 9646:LOC100468005
uniprot id: A0A7N5KI95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ANKRD34B
gene id: 9646:ANKRD34B
uniprot id: D2H3N9
names: Similarity
messages: Belongs to the ANKRD34 family.

9646:NCF2
gene id: 9646:NCF2
uniprot id: G1L6U4
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9646:HCFC2
gene id: 9646:HCFC2
uniprot id: A0A7N5KNY3
uniprot id: A0A7N5P6D5
uniprot id: D2H1T2
names: Subcellular Location Annotation
messages: Nucleus

9646:TTC26
gene id: 9646:TTC26
uniprot id: A0A7N5JGW8
names: Similarity
messages: Belongs to the IFT56 family.

9646:LIMK2
gene id: 9646:LIMK2
uniprot id: A0A7N5J9M3
uniprot id: G1LKS6
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9646:GTF2B
gene id: 9646:GTF2B
uniprot id: G1MCK2
names: Similarity
messages: Belongs to the TFIIB family.

9646:CRYBB2
gene id: 9646:CRYBB2
uniprot id: G1MHW4
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9646:NOP10
gene id: 9646:NOP10
uniprot id: D2I545
names: Similarity
messages: Belongs to the NOP10 family.

9646:LOC100478083
gene id: 9646:LOC100478083
uniprot id: G1MPB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:PGAP1
gene id: 9646:PGAP1
uniprot id: D2HDI6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:MARVELD2
gene id: 9646:MARVELD2
uniprot id: A0A7N5JBK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9646:KIF18B
gene id: 9646:KIF18B
uniprot id: G1MJA3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9646:MTCH2
gene id: 9646:MTCH2
uniprot id: D2HHL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:LOC100474931
gene id: 9646:LOC100474931
uniprot id: G1LDT9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:TMEM150A
gene id: 9646:TMEM150A
uniprot id: G1L673
names: Subcellular Location Annotation
messages: Membrane

9646:SNRNP200
gene id: 9646:SNRNP200
uniprot id: G1LR17
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9646:INA
gene id: 9646:INA
uniprot id: D2GXX6
names: Similarity
messages: Belongs to the intermediate filament family.

9646:MS4A1
gene id: 9646:MS4A1
uniprot id: G1L0L4
names: Similarity
messages: Belongs to the MS4A family.

9646:RNF170
gene id: 9646:RNF170
uniprot id: G1LED2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:LPAR6
gene id: 9646:LPAR6
uniprot id: G1MK04
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:TTI2
gene id: 9646:TTI2
uniprot id: G1L7X2
names: Similarity
messages: Belongs to the TTI2 family.

9646:AMZ1
gene id: 9646:AMZ1
uniprot id: D2I4M2
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9646:ADAMDEC1
gene id: 9646:ADAMDEC1
uniprot id: G1L469
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:LOC100483510
gene id: 9646:LOC100483510
uniprot id: G1MM59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9646:LOC100471307
gene id: 9646:LOC100471307
uniprot id: A0A7N5K185
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9646:TSSC4
gene id: 9646:TSSC4
uniprot id: D2HDT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TSSC4 family.
messages: Cytoplasm
messages: Nucleus

9646:PA2G4
gene id: 9646:PA2G4
uniprot id: D2H342
names: Similarity
messages: Belongs to the peptidase M24 family.

9646:TMEM254
gene id: 9646:TMEM254
uniprot id: A0A7N5KAT8
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100475860
gene id: 9646:LOC100475860
uniprot id: G1LBC0
names: Similarity
messages: Belongs to the PRORSD1 family.

9646:APEX2
gene id: 9646:APEX2
uniprot id: D2I7U1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9646:SERPINB2
gene id: 9646:SERPINB2
uniprot id: G1M9G4
names: Similarity
messages: Belongs to the serpin family.

9646:STX10
gene id: 9646:STX10
uniprot id: G1M1W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9646:LOC100470039
gene id: 9646:LOC100470039
uniprot id: G1MJN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:NOL6
gene id: 9646:NOL6
uniprot id: G1LLI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: nucleolus

9646:LOC100480630
gene id: 9646:LOC100480630
uniprot id: G1MAG9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9646:CDK6
gene id: 9646:CDK6
uniprot id: A0A7N5KAU0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:AKR1B1
gene id: 9646:AKR1B1
uniprot id: G1MCH6
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9646:KIF5A
gene id: 9646:KIF5A
uniprot id: A0A7N5JT79
uniprot id: G1LES0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9646:IFNK
gene id: 9646:IFNK
uniprot id: D2HTQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9646:EXOC3
gene id: 9646:EXOC3
uniprot id: D2HVI3
names: Similarity
messages: Belongs to the SEC6 family.

9646:AP4B1
gene id: 9646:AP4B1
uniprot id: D2H8V9
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9646:BTD
gene id: 9646:BTD
uniprot id: A0A7N5JZW3
uniprot id: A0A7N5K8Q0
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9646:MED6
gene id: 9646:MED6
uniprot id: A0A7N5JSA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9646:ALDH8A1
gene id: 9646:ALDH8A1
uniprot id: D2H0U5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9646:RECQL5
gene id: 9646:RECQL5
uniprot id: G1LSQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9646:AP1G1
gene id: 9646:AP1G1
uniprot id: D2HFW7
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9646:SRP14
gene id: 9646:SRP14
uniprot id: G1MFR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

9646:RIOK2
gene id: 9646:RIOK2
uniprot id: G1M7U1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9646:LIPT2
gene id: 9646:LIPT2
uniprot id: D2H1E3
names: Similarity
messages: Belongs to the LipB family.

9646:ITIH1
gene id: 9646:ITIH1
uniprot id: G1LP37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9646:SERINC1
gene id: 9646:SERINC1
uniprot id: A0A7N5KA10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9646:LOC109488528
gene id: 9646:LOC109488528
uniprot id: G1MN32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:G6PD
gene id: 9646:G6PD
uniprot id: A0A7N5KEA1
uniprot id: A0A7N5P323
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

9646:RELL1
gene id: 9646:RELL1
uniprot id: G1LXP7
names: Similarity
messages: Belongs to the RELT family.

9646:PRKRIP1
gene id: 9646:PRKRIP1
uniprot id: G1MAB8
names: Similarity
messages: Belongs to the PRKRIP1 family.

9646:VGLL1
gene id: 9646:VGLL1
uniprot id: G1L838
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9646:WAPL
gene id: 9646:WAPL
uniprot id: G1LTK3
names: Similarity
messages: Belongs to the WAPL family.

9646:CDSN
gene id: 9646:CDSN
uniprot id: G1LV63
names: Function
names: Subcellular Location Annotation
messages: Important for the epidermal barrier integrity.
messages: Secreted

9646:GOLT1A
gene id: 9646:GOLT1A
uniprot id: A0A7N5KNK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9646:HTR2A
gene id: 9646:HTR2A
uniprot id: D2H0K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

9646:CAMK1D
gene id: 9646:CAMK1D
uniprot id: G1MH77
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:CEBPZ
gene id: 9646:CEBPZ
uniprot id: G1MGU7
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9646:STAG1
gene id: 9646:STAG1
uniprot id: G1LII1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9646:HS3ST5
gene id: 9646:HS3ST5
uniprot id: D2HKE9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9646:ABR
gene id: 9646:ABR
uniprot id: A0A7N5JX14
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9646:PRICKLE1
gene id: 9646:PRICKLE1
uniprot id: D2HHV9
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9646:CLP1
gene id: 9646:CLP1
uniprot id: D2HK67
names: Subcellular Location Annotation
messages: Nucleus

9646:ATG13
gene id: 9646:ATG13
uniprot id: A0A7N5JE60
uniprot id: A0A7N5JM52
uniprot id: G1LJU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9646:IPO13
gene id: 9646:IPO13
uniprot id: G1L2U6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

9646:HPD
gene id: 9646:HPD
uniprot id: G1M7I4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9646:LOC100468404
gene id: 9646:LOC100468404
uniprot id: D2H2K2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:MED30
gene id: 9646:MED30
uniprot id: A0A7N5JJ84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9646:PNP
gene id: 9646:PNP
uniprot id: G1LFJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9646:EGR1
gene id: 9646:EGR1
uniprot id: D2HK98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9646:TOP3B
gene id: 9646:TOP3B
uniprot id: G1LLS2
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9646:LSM6
gene id: 9646:LSM6
uniprot id: G1ME25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9646:MED21
gene id: 9646:MED21
uniprot id: G1LYW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9646:LOC100479790
gene id: 9646:LOC100479790
uniprot id: G1M3K6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9646:FNTB
gene id: 9646:FNTB
uniprot id: G1L9W0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
messages: Heterodimer of FNTA and FNTB.

9646:BLMH
gene id: 9646:BLMH
uniprot id: G1LB93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9646:EHD3
gene id: 9646:EHD3
uniprot id: D2HWC5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9646:HOXB7
gene id: 9646:HOXB7
uniprot id: D2H569
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9646:USP5
gene id: 9646:USP5
uniprot id: G1M5W5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9646:YDJC
gene id: 9646:YDJC
uniprot id: G1LQA8
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

9646:DXO
gene id: 9646:DXO
uniprot id: G1L5W1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

9646:VRTN
gene id: 9646:VRTN
uniprot id: D2GZW6
names: Similarity
messages: Belongs to the vertnin family.

9646:FAM72A
gene id: 9646:FAM72A
uniprot id: D2HZZ7
uniprot id: G1M1Z6
names: Similarity
messages: Belongs to the FAM72 family.

9646:CTSV
gene id: 9646:CTSV
uniprot id: D2I4U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9646:CCR6
gene id: 9646:CCR6
uniprot id: A0A7N5P0J1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:METTL1
gene id: 9646:METTL1
uniprot id: G1LFP9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with WDR4.
messages: Nucleus
messages: Phosphorylation at Ser-28 inactivates its catalytic activity but does not affect the interaction with WDR4.

9646:PPP2R5E
gene id: 9646:PPP2R5E
uniprot id: G1LBY2
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9646:HOXA1
gene id: 9646:HOXA1
uniprot id: D2GVC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9646:LOC100472954
gene id: 9646:LOC100472954
uniprot id: D2HU51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:SERPINB7
gene id: 9646:SERPINB7
uniprot id: D2HUT2
names: Similarity
messages: Belongs to the serpin family.

9646:LOC100481484
gene id: 9646:LOC100481484
uniprot id: D2H324
names: Similarity
messages: Belongs to the cytochrome P450 family.

9646:MUSTN1
gene id: 9646:MUSTN1
uniprot id: G1LN93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

9646:PPP6C
gene id: 9646:PPP6C
uniprot id: D2H3W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9646:MECOM
gene id: 9646:MECOM
uniprot id: G1L5N6
uniprot id: G1L5P4
names: Subcellular Location Annotation
messages: Nucleus

9646:PPP2CA
gene id: 9646:PPP2CA
uniprot id: G1MHI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9646:VPS18
gene id: 9646:VPS18
uniprot id: D2GW94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9646:TERF2IP
gene id: 9646:TERF2IP
uniprot id: D2HY19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

9646:STX4
gene id: 9646:STX4
uniprot id: G1LLH9
names: Similarity
messages: Belongs to the syntaxin family.

9646:GDPGP1
gene id: 9646:GDPGP1
uniprot id: G1MKX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

9646:SMIM19
gene id: 9646:SMIM19
uniprot id: G1LEL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9646:USO1
gene id: 9646:USO1
uniprot id: G1M7I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

9646:GPATCH1
gene id: 9646:GPATCH1
uniprot id: G1MAT3
names: Similarity
messages: Belongs to the GPATCH1 family.

9646:TNPO1
gene id: 9646:TNPO1
uniprot id: A0A7N5JA56
names: Subcellular Location Annotation
messages: Cytoplasm

9646:RAD51
gene id: 9646:RAD51
uniprot id: A0A7N5P495
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

9646:GGPS1
gene id: 9646:GGPS1
uniprot id: G1L2S4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9646:GJB2
gene id: 9646:GJB2
uniprot id: D2I6K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9646:RPS19
gene id: 9646:RPS19
uniprot id: B7SBG1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

9646:PDE7A
gene id: 9646:PDE7A
uniprot id: G1M0V5
uniprot id: G1M0V8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9646:GPN3
gene id: 9646:GPN3
uniprot id: G1M5U4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9646:PKNOX2
gene id: 9646:PKNOX2
uniprot id: D2HNK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9646:MEOX2
gene id: 9646:MEOX2
uniprot id: D2H6P7
names: Subcellular Location Annotation
messages: Nucleus

9646:ACP1
gene id: 9646:ACP1
uniprot id: A0A7N5KC67
uniprot id: G1LSJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9646:THBD
gene id: 9646:THBD
uniprot id: D2HSG5
names: Caution
names: Function
names: Subunit
messages: Interacts with ITGAL, ITGAM and ITGB2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

9646:LOC100478873
gene id: 9646:LOC100478873
uniprot id: D2I0D5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:MRPL2
gene id: 9646:MRPL2
uniprot id: G1M1M2
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9646:SLC7A6OS
gene id: 9646:SLC7A6OS
uniprot id: D2HLJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

9646:CNTN1
gene id: 9646:CNTN1
uniprot id: A0A7N5JV13
uniprot id: A0A7N5P238
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9646:NDC80
gene id: 9646:NDC80
uniprot id: D2HU10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9646:PIGF
gene id: 9646:PIGF
uniprot id: D2GUA8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:ACTR1B
gene id: 9646:ACTR1B
uniprot id: G1LF46
names: Similarity
messages: Belongs to the actin family.

9646:IL17F
gene id: 9646:IL17F
uniprot id: A0A7N5JBI7
uniprot id: A0A7N5JWH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9646:GRK7
gene id: 9646:GRK7
uniprot id: D2H585
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9646:SLC6A11
gene id: 9646:SLC6A11
uniprot id: D2I1Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9646:NSG1
gene id: 9646:NSG1
uniprot id: A0A7N5JX87
names: Similarity
messages: Belongs to the NSG family.

9646:GYS1
gene id: 9646:GYS1
uniprot id: D2H7X7
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9646:SPACA3
gene id: 9646:SPACA3
uniprot id: G1LGN8
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9646:WNT2
gene id: 9646:WNT2
uniprot id: G1L360
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9646:TESMIN
gene id: 9646:TESMIN
uniprot id: D2I297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9646:DLL1
gene id: 9646:DLL1
uniprot id: G1MF60
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9646:HAO1
gene id: 9646:HAO1
uniprot id: G1MC49
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9646:LIN7C
gene id: 9646:LIN7C
uniprot id: G1M7J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9646:RNF34
gene id: 9646:RNF34
uniprot id: A0A7N5K6X6
names: Subcellular Location Annotation
messages: Cell membrane

9646:CHRNA6
gene id: 9646:CHRNA6
uniprot id: G1LEH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:HOXC8
gene id: 9646:HOXC8
uniprot id: D2HM45
names: Subcellular Location Annotation
messages: Nucleus

9646:MIPEP
gene id: 9646:MIPEP
uniprot id: D2HF51
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9646:GSTZ1
gene id: 9646:GSTZ1
uniprot id: A0A7N5JFW6
uniprot id: G1LAV2
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9646:SLC16A10
gene id: 9646:SLC16A10
uniprot id: D2I3S0
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100475844
gene id: 9646:LOC100475844
uniprot id: D2I4C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GCNT3
gene id: 9646:GCNT3
uniprot id: D2HV92
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9646:DEGS2
gene id: 9646:DEGS2
uniprot id: D2H6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Membrane

9646:MLF2
gene id: 9646:MLF2
uniprot id: D2HJ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9646:IQCD
gene id: 9646:IQCD
uniprot id: G1LQ84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

9646:CHRNA9
gene id: 9646:CHRNA9
uniprot id: D2I181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:STAT6
gene id: 9646:STAT6
uniprot id: D2H375
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9646:SLC5A12
gene id: 9646:SLC5A12
uniprot id: G1LCK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9646:KCNH8
gene id: 9646:KCNH8
uniprot id: G1LLM3
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9646:GSK3B
gene id: 9646:GSK3B
uniprot id: G1LKA6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9646:RAP2B
gene id: 9646:RAP2B
uniprot id: D2H407
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9646:SS18
gene id: 9646:SS18
uniprot id: A0A7N5JW36
uniprot id: G1M6F9
names: Similarity
messages: Belongs to the SS18 family.

9646:APAF1
gene id: 9646:APAF1
uniprot id: G1LWB3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
messages: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

9646:RSAD2
gene id: 9646:RSAD2
uniprot id: D2HGH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9646:LACC1
gene id: 9646:LACC1
uniprot id: D2H0I9
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

9646:DEDD
gene id: 9646:DEDD
uniprot id: A0A7N5KPY5
names: Subcellular Location Annotation
messages: nucleolus

9646:SH3BGRL
gene id: 9646:SH3BGRL
uniprot id: A0A7N5JZR6
names: Similarity
messages: Belongs to the SH3BGR family.

9646:PLD1
gene id: 9646:PLD1
uniprot id: A0A7N5JAP3
uniprot id: D2HHF7
names: Similarity
messages: Belongs to the phospholipase D family.

9646:TMEM120B
gene id: 9646:TMEM120B
uniprot id: G1M791
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9646:ACVR2A
gene id: 9646:ACVR2A
uniprot id: G1M4A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9646:APP
gene id: 9646:APP
uniprot id: A0A7N5JN45
uniprot id: A0A7N5JSB7
uniprot id: A0A7N5K3J6
uniprot id: G1MFV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
messages: Nucleus
messages: Perikaryon
messages: Secreted
messages: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
messages: Vesicle
messages: clathrin-coated pit
messages: growth cone

9646:RAB3GAP2
gene id: 9646:RAB3GAP2
uniprot id: G1LUD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

9646:MCM9
gene id: 9646:MCM9
uniprot id: A0A7N5JP55
uniprot id: G1LA69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9646:DPPA5
gene id: 9646:DPPA5
uniprot id: D2H4J1
names: Similarity
messages: Belongs to the KHDC1 family.

9646:PLSCR5
gene id: 9646:PLSCR5
uniprot id: G1L5R4
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9646:TMLHE
gene id: 9646:TMLHE
uniprot id: D2I4U4
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

9646:LANCL2
gene id: 9646:LANCL2
uniprot id: G1LRL3
names: Similarity
messages: Belongs to the LanC-like protein family.

9646:IRF6
gene id: 9646:IRF6
uniprot id: D2HIJ4
names: Subcellular Location Annotation
messages: Nucleus

9646:TMEM182
gene id: 9646:TMEM182
uniprot id: A0A7N5KAC2
uniprot id: A0A7N5KLB7
uniprot id: A0A7N5P4H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9646:EBP
gene id: 9646:EBP
uniprot id: D2H7P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:PROKR2
gene id: 9646:PROKR2
uniprot id: D2HQS9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:SCAMP2
gene id: 9646:SCAMP2
uniprot id: G1LQ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9646:ATP6V1F
gene id: 9646:ATP6V1F
uniprot id: D2GWS3
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

9646:HOXA6
gene id: 9646:HOXA6
uniprot id: D2GVB9
uniprot id: G1LH22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9646:BCAP31
gene id: 9646:BCAP31
uniprot id: G1LQ55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9646:CEP57
gene id: 9646:CEP57
uniprot id: A0A7N5JJS6
names: Similarity
messages: Belongs to the translokin family.

9646:DCAF11
gene id: 9646:DCAF11
uniprot id: D2HG59
names: Function
names: Subunit
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9646:RPL10L
gene id: 9646:RPL10L
uniprot id: D2HWA8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9646:TUBE1
gene id: 9646:TUBE1
uniprot id: D2H642
names: Similarity
messages: Belongs to the tubulin family.

9646:MMUT
gene id: 9646:MMUT
uniprot id: D2H1P9
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

9646:ASAH1
gene id: 9646:ASAH1
uniprot id: G1M4K5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9646:RIPPLY1
gene id: 9646:RIPPLY1
uniprot id: A0A7N5KED5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9646:MANBA
gene id: 9646:MANBA
uniprot id: G1LQX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

9646:HNF4A
gene id: 9646:HNF4A
uniprot id: A0A7N5KKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9646:MANEA
gene id: 9646:MANEA
uniprot id: D2I2H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:LOC100478524
gene id: 9646:LOC100478524
uniprot id: D2I307
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:SEMA3E
gene id: 9646:SEMA3E
uniprot id: A0A7N5P488
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:LAMC1
gene id: 9646:LAMC1
uniprot id: D2HN94
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9646:ADAMTS6
gene id: 9646:ADAMTS6
uniprot id: G1LXA0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9646:PDCL2
gene id: 9646:PDCL2
uniprot id: G1MJD9
names: Similarity
messages: Belongs to the phosducin family.

9646:SERPINE1
gene id: 9646:SERPINE1
uniprot id: D2I5Z6
names: Similarity
messages: Belongs to the serpin family.

9646:RPRD1B
gene id: 9646:RPRD1B
uniprot id: D2H111
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9646:LOC100484971
gene id: 9646:LOC100484971
uniprot id: D2HWP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9646:SKA1
gene id: 9646:SKA1
uniprot id: D2I4J3
names: Similarity
messages: Belongs to the SKA1 family.

9646:SNRPC
gene id: 9646:SNRPC
uniprot id: A0A7N5K7W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

9646:ANAPC16
gene id: 9646:ANAPC16
uniprot id: D2HZB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9646:PATZ1
gene id: 9646:PATZ1
uniprot id: A0A7N5JHD1
uniprot id: A0A7N5JLY8
uniprot id: D2H203
names: Subcellular Location Annotation
messages: Nucleus

9646:UXT
gene id: 9646:UXT
uniprot id: A0A7N5JW33
names: Similarity
messages: Belongs to the UXT family.

9646:CCNB3
gene id: 9646:CCNB3
uniprot id: A0A7N5JID9
names: Similarity
messages: Belongs to the cyclin family.

9646:SNURF
gene id: 9646:SNURF
uniprot id: G1LKD6
names: Similarity
messages: Belongs to the SNURF family.

9646:GBX1
gene id: 9646:GBX1
uniprot id: D2H1V6
names: Subcellular Location Annotation
messages: Nucleus

9646:PURA
gene id: 9646:PURA
uniprot id: D2GUP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9646:PPP1R2
gene id: 9646:PPP1R2
uniprot id: G1LS51
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9646:NDUFAF1
gene id: 9646:NDUFAF1
uniprot id: D2GW87
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9646:FLOT1
gene id: 9646:FLOT1
uniprot id: G1M3G5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: Membrane
messages: caveola

9646:TSG101
gene id: 9646:TSG101
uniprot id: G1MHQ6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

9646:RPS15A
gene id: 9646:RPS15A
uniprot id: D3YBZ8
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

9646:CAV1
gene id: 9646:CAV1
uniprot id: A0A7N5P9J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9646:LOC100479705
gene id: 9646:LOC100479705
uniprot id: G1MM69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:MYADML2
gene id: 9646:MYADML2
uniprot id: D2GVE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9646:LOC100472839
gene id: 9646:LOC100472839
uniprot id: G1M079
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

9646:LOC100480434
gene id: 9646:LOC100480434
uniprot id: D2HK74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:SEPSECS
gene id: 9646:SEPSECS
uniprot id: D2I455
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9646:ATP4B
gene id: 9646:ATP4B
uniprot id: D2HTR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9646:LLPH
gene id: 9646:LLPH
uniprot id: D2HQH7
names: Similarity
messages: Belongs to the learning-associated protein family.

9646:SLC2A2
gene id: 9646:SLC2A2
uniprot id: G1LDS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9646:LOC100465213
gene id: 9646:LOC100465213
uniprot id: F2X266
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9646:JAK3
gene id: 9646:JAK3
uniprot id: D2GV17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Endomembrane system

9646:SMG8
gene id: 9646:SMG8
uniprot id: D2HLV2
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

9646:WDR3
gene id: 9646:WDR3
uniprot id: D2HQ25
names: Subcellular Location Annotation
messages: nucleolus

9646:LIPH
gene id: 9646:LIPH
uniprot id: G1MEH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9646:CARTPT
gene id: 9646:CARTPT
uniprot id: D2H2V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9646:AMPD3
gene id: 9646:AMPD3
uniprot id: G1LA55
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9646:SLC43A2
gene id: 9646:SLC43A2
uniprot id: G1LN45
names: Subcellular Location Annotation
messages: Membrane

9646:PXMP4
gene id: 9646:PXMP4
uniprot id: G1LQY5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

9646:ABI2
gene id: 9646:ABI2
uniprot id: A0A7N5JDP3
uniprot id: D2HB84
uniprot id: G1M2U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9646:SPOPL
gene id: 9646:SPOPL
uniprot id: D2HPC9
names: Similarity
messages: Belongs to the Tdpoz family.

9646:PRDX6
gene id: 9646:PRDX6
uniprot id: D2H5H7
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

9646:DLAT
gene id: 9646:DLAT
uniprot id: D2HG83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9646:NIPSNAP2
gene id: 9646:NIPSNAP2
uniprot id: A0A7N5JU58
names: Similarity
messages: Belongs to the NipSnap family.

9646:GORASP2
gene id: 9646:GORASP2
uniprot id: G1LQ80
names: Similarity
messages: Belongs to the GORASP family.

9646:SNU13
gene id: 9646:SNU13
uniprot id: G1MAQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9646:SMIM12
gene id: 9646:SMIM12
uniprot id: D2H617
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM12 family.
messages: Membrane

9646:MED17
gene id: 9646:MED17
uniprot id: D2I2X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9646:GJA8
gene id: 9646:GJA8
uniprot id: D2HQ39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9646:COL4A5
gene id: 9646:COL4A5
uniprot id: G1M069
uniprot id: G1M077
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9646:HBE1
gene id: 9646:HBE1
uniprot id: A0A7N5JUX4
names: Similarity
messages: Belongs to the globin family.

9646:NPRL3
gene id: 9646:NPRL3
uniprot id: D2HDV0
uniprot id: G1LJW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome

9646:TES
gene id: 9646:TES
uniprot id: A0A7N5KSQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.
messages: focal adhesion

9646:MAB21L1
gene id: 9646:MAB21L1
uniprot id: D2HM76
names: Similarity
messages: Belongs to the mab-21 family.

9646:GNPDA2
gene id: 9646:GNPDA2
uniprot id: A0A7N5P203
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9646:RIDA
gene id: 9646:RIDA
uniprot id: G1L170
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9646:LOXHD1
gene id: 9646:LOXHD1
uniprot id: A0A7N5JMH8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:GH1
gene id: 9646:GH1
uniprot id: A0A7N5JGI6
uniprot id: Q8HYE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity).
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9646:SMAD5
gene id: 9646:SMAD5
uniprot id: D2GVL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9646:TAS2R40
gene id: 9646:TAS2R40
uniprot id: D2HP48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9646:RPLP2
gene id: 9646:RPLP2
uniprot id: F2X232
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9646:TADA1
gene id: 9646:TADA1
uniprot id: G1M675
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

9646:GTF2F2
gene id: 9646:GTF2F2
uniprot id: G1M2Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9646:C14H22orf39
gene id: 9646:C14H22orf39
uniprot id: A0A7N5JQV6
names: Similarity
messages: Belongs to the UPF0545 family.

9646:ABL2
gene id: 9646:ABL2
uniprot id: A0A7N5JA84
uniprot id: A0A7N5JKZ5
uniprot id: G1M7W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9646:EXTL2
gene id: 9646:EXTL2
uniprot id: A0A7N5K0I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:CDC42BPA
gene id: 9646:CDC42BPA
uniprot id: A0A7N5JJ91
uniprot id: G1LQY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9646:FAT2
gene id: 9646:FAT2
uniprot id: D2HFC7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:TRHR
gene id: 9646:TRHR
uniprot id: D2HA59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9646:AARS1
gene id: 9646:AARS1
uniprot id: G1LE07
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9646:PRODH2
gene id: 9646:PRODH2
uniprot id: G1L1G5
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

9646:ACO2
gene id: 9646:ACO2
uniprot id: G1MB13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

9646:STARD8
gene id: 9646:STARD8
uniprot id: G1L694
names: Subcellular Location Annotation
messages: Cytoplasm

9646:TAS1R2
gene id: 9646:TAS1R2
uniprot id: D2HVZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:HTR1A
gene id: 9646:HTR1A
uniprot id: D2HUM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
messages: Membrane
messages: dendrite

9646:PUS10
gene id: 9646:PUS10
uniprot id: G1MIU3
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

9646:WDR12
gene id: 9646:WDR12
uniprot id: G1M3A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9646:HNRNPK
gene id: 9646:HNRNPK
uniprot id: G1LB97
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9646:ESCO2
gene id: 9646:ESCO2
uniprot id: A0A7N5PAQ7
names: Subcellular Location Annotation
messages: Nucleus

9646:DAG1
gene id: 9646:DAG1
uniprot id: D2HEU8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9646:SEPTIN14
gene id: 9646:SEPTIN14
uniprot id: G1MCL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9646:ARSJ
gene id: 9646:ARSJ
uniprot id: A0A7N5P9Y7
names: Similarity
messages: Belongs to the sulfatase family.

9646:CCNO
gene id: 9646:CCNO
uniprot id: D2I0X7
names: Similarity
messages: Belongs to the cyclin family.

9646:MRPL14
gene id: 9646:MRPL14
uniprot id: G1M040
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9646:LOC100479661
gene id: 9646:LOC100479661
uniprot id: A0A7N5P8M9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm

9646:ATP6V1C1
gene id: 9646:ATP6V1C1
uniprot id: D2HJW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9646:SDHD
gene id: 9646:SDHD
uniprot id: G1LBK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9646:USP3
gene id: 9646:USP3
uniprot id: D2GYQ7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9646:SLC4A4
gene id: 9646:SLC4A4
uniprot id: G1LHJ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

9646:EGFL8
gene id: 9646:EGFL8
uniprot id: A0A7N5K8U7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:MAT1A
gene id: 9646:MAT1A
uniprot id: D2HJG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9646:LOC100469449
gene id: 9646:LOC100469449
uniprot id: D2HWI7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:ATP5PD
gene id: 9646:ATP5PD
uniprot id: D2HD33
names: Function
names: Similarity
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

9646:SERPINA14
gene id: 9646:SERPINA14
uniprot id: F9W2V9
names: Similarity
messages: Belongs to the serpin family.

9646:HSD17B7
gene id: 9646:HSD17B7
uniprot id: G1L3U6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

9646:HSD3B1
gene id: 9646:HSD3B1
uniprot id: G1MH48
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9646:N6AMT1
gene id: 9646:N6AMT1
uniprot id: D2HGA9
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

9646:LOC100470134
gene id: 9646:LOC100470134
uniprot id: A0A7N5P6E3
uniprot id: G1M4M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

9646:TMEM59
gene id: 9646:TMEM59
uniprot id: D2H2G2
uniprot id: G1LT40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:VAMP7
gene id: 9646:VAMP7
uniprot id: A0A7N5KH14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9646:NAP1L3
gene id: 9646:NAP1L3
uniprot id: D2I213
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9646:LYG2
gene id: 9646:LYG2
uniprot id: G1M3Y2
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9646:GRWD1
gene id: 9646:GRWD1
uniprot id: D2H7Z8
names: Subcellular Location Annotation
messages: Nucleus

9646:MED24
gene id: 9646:MED24
uniprot id: D2I2E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9646:TNFSF8
gene id: 9646:TNFSF8
uniprot id: D2H2H7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9646:CNDP2
gene id: 9646:CNDP2
uniprot id: G1LD33
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9646:LOC100479513
gene id: 9646:LOC100479513
uniprot id: G1ML81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:MRPS18B
gene id: 9646:MRPS18B
uniprot id: G1M3S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

9646:NUP98
gene id: 9646:NUP98
uniprot id: G1LWU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

9646:H1-1
gene id: 9646:H1-1
uniprot id: D2I077
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9646:RNF20
gene id: 9646:RNF20
uniprot id: G1L1A0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9646:NFYA
gene id: 9646:NFYA
uniprot id: A0A7N5JZH7
uniprot id: G1LCR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9646:MIOS
gene id: 9646:MIOS
uniprot id: A0A7N5KDF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane

9646:ITM2B
gene id: 9646:ITM2B
uniprot id: G1LAI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9646:SIAH3
gene id: 9646:SIAH3
uniprot id: D2H0K2
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9646:CNOT7
gene id: 9646:CNOT7
uniprot id: D2HN30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9646:ARFGEF2
gene id: 9646:ARFGEF2
uniprot id: D2GVP9
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9646:SLC6A20
gene id: 9646:SLC6A20
uniprot id: D2GV75
names: Subcellular Location Annotation
messages: Membrane

9646:KCNJ3
gene id: 9646:KCNJ3
uniprot id: A0A7N5JTZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

9646:LOC100477187
gene id: 9646:LOC100477187
uniprot id: G1MM28
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:LOC100468897
gene id: 9646:LOC100468897
uniprot id: F2X213
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9646:SBDS
gene id: 9646:SBDS
uniprot id: D2HW33
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9646:CCNB2
gene id: 9646:CCNB2
uniprot id: G1LDA3
names: Similarity
messages: Belongs to the cyclin family.

9646:MTX2
gene id: 9646:MTX2
uniprot id: A0A7N5JLG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9646:VGLL4
gene id: 9646:VGLL4
uniprot id: A0A7N5JF31
uniprot id: A0A7N5JSQ1
uniprot id: G1LWX7
uniprot id: G1LWY3
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

9646:EMC7
gene id: 9646:EMC7
uniprot id: D2HRS2
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

9646:CDC73
gene id: 9646:CDC73
uniprot id: A0A7N5KIN1
uniprot id: G1MBL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

9646:RPS3
gene id: 9646:RPS3
uniprot id: F2X1Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: spindle

9646:ATP13A5
gene id: 9646:ATP13A5
uniprot id: G1MBW2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:PTGS2
gene id: 9646:PTGS2
uniprot id: G1MAL9
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:DMC1
gene id: 9646:DMC1
uniprot id: G1LVW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

9646:CHCHD4
gene id: 9646:CHCHD4
uniprot id: G1LS95
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

9646:LOC100468463
gene id: 9646:LOC100468463
uniprot id: G1MN24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:PLA2G4A
gene id: 9646:PLA2G4A
uniprot id: G1MAR8
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

9646:LOC100471943
gene id: 9646:LOC100471943
uniprot id: D2HI69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TOM1L1
gene id: 9646:TOM1L1
uniprot id: G1M7Z6
names: Similarity
messages: Belongs to the TOM1 family.

9646:AMT
gene id: 9646:AMT
uniprot id: D2HEV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9646:MSH6
gene id: 9646:MSH6
uniprot id: D2GUB6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

9646:FOXG1
gene id: 9646:FOXG1
uniprot id: D2HJI4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.

9646:ARL5B
gene id: 9646:ARL5B
uniprot id: A0A7N5KBS5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9646:ARHGEF12
gene id: 9646:ARHGEF12
uniprot id: A0A7N5KPZ9
uniprot id: G1LN95
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9646:SLC26A3
gene id: 9646:SLC26A3
uniprot id: G1M5R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane

9646:TMEM176B
gene id: 9646:TMEM176B
uniprot id: D2H1W4
names: Similarity
messages: Belongs to the TMEM176 family.

9646:SMAD1
gene id: 9646:SMAD1
uniprot id: D2H3Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9646:LOC100477944
gene id: 9646:LOC100477944
uniprot id: D2I5Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:UGCG
gene id: 9646:UGCG
uniprot id: D2H4E2
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9646:OGT
gene id: 9646:OGT
uniprot id: G1MCJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9646:LOC100473638
gene id: 9646:LOC100473638
uniprot id: D2HGS3
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9646:SPICE1
gene id: 9646:SPICE1
uniprot id: G1LEY1
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

9646:F10
gene id: 9646:F10
uniprot id: G1LUQ6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:TMBIM4
gene id: 9646:TMBIM4
uniprot id: G1KZQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9646:PDE6G
gene id: 9646:PDE6G
uniprot id: G1MGS6
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9646:TRPM7
gene id: 9646:TRPM7
uniprot id: G1LR58
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

9646:NQO1
gene id: 9646:NQO1
uniprot id: G1LJI8
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9646:BTK
gene id: 9646:BTK
uniprot id: A0A7N5K6N1
uniprot id: G1LS18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9646:SPG21
gene id: 9646:SPG21
uniprot id: A0A7N5P5I3
names: Function
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9646:SERPINB12
gene id: 9646:SERPINB12
uniprot id: D2H6Z8
names: Similarity
messages: Belongs to the serpin family.

9646:LOC100464876
gene id: 9646:LOC100464876
uniprot id: D2GUE7
names: Similarity
messages: Belongs to the cornifelin family.

9646:CPNE1
gene id: 9646:CPNE1
uniprot id: G1LTK9
uniprot id: G1MLJ9
names: Similarity
messages: Belongs to the copine family.

9646:LOC100465190
gene id: 9646:LOC100465190
uniprot id: D2HWJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:PHKA1
gene id: 9646:PHKA1
uniprot id: A0A7N5JN92
uniprot id: A0A7N5K670
uniprot id: A0A7N5PAX1
uniprot id: G1LH67
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9646:FAM3D
gene id: 9646:FAM3D
uniprot id: G1M0A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9646:CNOT2
gene id: 9646:CNOT2
uniprot id: G1LZS8
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9646:SLC17A7
gene id: 9646:SLC17A7
uniprot id: G1M6F1
names: Subcellular Location Annotation
messages: Membrane

9646:ZDHHC17
gene id: 9646:ZDHHC17
uniprot id: G1LJ71
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9646:NDUFB6
gene id: 9646:NDUFB6
uniprot id: A0A7N5KBT6
uniprot id: G1LAX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9646:KCNE3
gene id: 9646:KCNE3
uniprot id: D2H1E4
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9646:HMCES
gene id: 9646:HMCES
uniprot id: G1M9S9
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

9646:CAPZA1
gene id: 9646:CAPZA1
uniprot id: G1LA48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9646:TRAPPC6A
gene id: 9646:TRAPPC6A
uniprot id: G1M1R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9646:ARL8A
gene id: 9646:ARL8A
uniprot id: G1LZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: spindle

9646:GET3
gene id: 9646:GET3
uniprot id: G1M0I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

9646:RPL8
gene id: 9646:RPL8
uniprot id: F2X241
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9646:SERBP1
gene id: 9646:SERBP1
uniprot id: G1LD20
names: Similarity
messages: Belongs to the SERBP1-HABP4 family.

9646:PRLHR
gene id: 9646:PRLHR
uniprot id: D2H1L4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:LOC100466687
gene id: 9646:LOC100466687
uniprot id: G1LCL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9646:FCF1
gene id: 9646:FCF1
uniprot id: G1MJ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9646:ATP6V1C2
gene id: 9646:ATP6V1C2
uniprot id: A0A7N5KHU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9646:CLIC1
gene id: 9646:CLIC1
uniprot id: G1LRE0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

9646:LUC7L3
gene id: 9646:LUC7L3
uniprot id: D2HTT6
uniprot id: G1LMK4
names: Similarity
messages: Belongs to the Luc7 family.

9646:HOGA1
gene id: 9646:HOGA1
uniprot id: D2H5K6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9646:TMEM150B
gene id: 9646:TMEM150B
uniprot id: G1LAJ2
names: Subcellular Location Annotation
messages: Membrane

9646:CAPN1
gene id: 9646:CAPN1
uniprot id: G1MH21
names: Similarity
messages: Belongs to the peptidase C2 family.

9646:TM9SF2
gene id: 9646:TM9SF2
uniprot id: G1LCS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9646:STX6
gene id: 9646:STX6
uniprot id: G1L7Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9646:EIF3H
gene id: 9646:EIF3H
uniprot id: G1LUW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9646:SLC10A2
gene id: 9646:SLC10A2
uniprot id: G1MDC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9646:ITGB3BP
gene id: 9646:ITGB3BP
uniprot id: A0A7N5JTT0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription coregulator that can have both coactivator and corepressor functions.
messages: centromere
messages: kinetochore

9646:LOC100499573
gene id: 9646:LOC100499573
uniprot id: P18983
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

9646:BRAT1
gene id: 9646:BRAT1
uniprot id: D2I4M3
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with BRCA1 and ATM. Interacts with MTOR, RPTOR, NDFIP1, SMC1A and PRKDC.
messages: Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors.
messages: Nucleus
messages: Ubiquitinated by NEDD4, NEDD4L and ITCH; mono- and polyubiquitinated forms are detected.

9646:NDUFA13
gene id: 9646:NDUFA13
uniprot id: G1LZK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

9646:LOC100478119
gene id: 9646:LOC100478119
uniprot id: D2I4D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GABRA3
gene id: 9646:GABRA3
uniprot id: G1M0C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:MTAP
gene id: 9646:MTAP
uniprot id: G1LLW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9646:LOC100484059
gene id: 9646:LOC100484059
uniprot id: G1MCH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GNG11
gene id: 9646:GNG11
uniprot id: D2H8V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9646:GAPDHS
gene id: 9646:GAPDHS
uniprot id: G1L0I3
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9646:SHMT2
gene id: 9646:SHMT2
uniprot id: G1LDQ8
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9646:SPX
gene id: 9646:SPX
uniprot id: G1MCQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

9646:SLC35E3
gene id: 9646:SLC35E3
uniprot id: G1LPM9
names: Subcellular Location Annotation
messages: Membrane

9646:ZDHHC16
gene id: 9646:ZDHHC16
uniprot id: A0A7N5JR20
uniprot id: D2H5K9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9646:CCDC153
gene id: 9646:CCDC153
uniprot id: G1KZI1
names: Similarity
messages: Belongs to the UPF0610 family.

9646:GNG3
gene id: 9646:GNG3
uniprot id: D2HS78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9646:CACYBP
gene id: 9646:CACYBP
uniprot id: G1KZY6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9646:MRPL11
gene id: 9646:MRPL11
uniprot id: G1LXY6
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9646:MFAP5
gene id: 9646:MFAP5
uniprot id: A0A7N5P2B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

9646:PHGDH
gene id: 9646:PHGDH
uniprot id: D2HZW5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9646:AGBL2
gene id: 9646:AGBL2
uniprot id: A0A7N5JSA9
uniprot id: A0A7N5KCW1
uniprot id: A0A7N5KQD6
uniprot id: G1LMG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9646:HTRA2
gene id: 9646:HTRA2
uniprot id: D2HH54
names: Similarity
messages: Belongs to the peptidase S1C family.

9646:PTPRA
gene id: 9646:PTPRA
uniprot id: G1LX95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

9646:IFRD2
gene id: 9646:IFRD2
uniprot id: G1LZ64
names: Similarity
messages: Belongs to the IFRD family.

9646:SUPT5H
gene id: 9646:SUPT5H
uniprot id: A0A7N5K4V1
uniprot id: G1LPC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9646:DNM1L
gene id: 9646:DNM1L
uniprot id: G1LQV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Cytoplasm

9646:NUP205
gene id: 9646:NUP205
uniprot id: G1M049
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

9646:GPR12
gene id: 9646:GPR12
uniprot id: D2HP86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:HYAL4
gene id: 9646:HYAL4
uniprot id: G1LD27
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9646:PLA2G4E
gene id: 9646:PLA2G4E
uniprot id: G1MD23
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9646:BANF2
gene id: 9646:BANF2
uniprot id: D2HRE2
names: Subcellular Location Annotation
messages: Nucleus

9646:HARS1
gene id: 9646:HARS1
uniprot id: D2GUN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

9646:LOC100477384
gene id: 9646:LOC100477384
uniprot id: D2H4E3
names: Similarity
messages: Belongs to the DNAJC25 family.

9646:CFL1
gene id: 9646:CFL1
uniprot id: G1MG27
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9646:NCBP2
gene id: 9646:NCBP2
uniprot id: G1LAE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9646:HAGH
gene id: 9646:HAGH
uniprot id: G1LPD0
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9646:ERGIC3
gene id: 9646:ERGIC3
uniprot id: G1LTG4
uniprot id: G1LTG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9646:NUF2
gene id: 9646:NUF2
uniprot id: G1LIY0
names: Similarity
messages: Belongs to the NUF2 family.

9646:BTN1A1
gene id: 9646:BTN1A1
uniprot id: G1MC10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9646:TMEM144
gene id: 9646:TMEM144
uniprot id: A0A7N5KKQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

9646:EXO1
gene id: 9646:EXO1
uniprot id: D2H9H2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

9646:UCMA
gene id: 9646:UCMA
uniprot id: G1M4I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

9646:SLC66A2
gene id: 9646:SLC66A2
uniprot id: A0A7N5JP48
uniprot id: D2HED4
names: Subcellular Location Annotation
messages: Membrane

9646:CMC1
gene id: 9646:CMC1
uniprot id: A0A7N5JYP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9646:MMS22L
gene id: 9646:MMS22L
uniprot id: G1L705
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MMS22 family. MMS22L subfamily.
messages: Chromosome
messages: Nucleus

9646:ABT1
gene id: 9646:ABT1
uniprot id: D2I669
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

9646:PPP1R15B
gene id: 9646:PPP1R15B
uniprot id: D2H8S4
names: Similarity
messages: Belongs to the PPP1R15 family.

9646:ST3GAL1
gene id: 9646:ST3GAL1
uniprot id: D2H3F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9646:RANBP6
gene id: 9646:RANBP6
uniprot id: D2I6D4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:HBM
gene id: 9646:HBM
uniprot id: D2HDV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9646:TLR10
gene id: 9646:TLR10
uniprot id: D2HZ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9646:BUD31
gene id: 9646:BUD31
uniprot id: G1LI45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9646:LARS2
gene id: 9646:LARS2
uniprot id: D2GV72
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9646:POLD2
gene id: 9646:POLD2
uniprot id: D2HNN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

9646:LOC100480454
gene id: 9646:LOC100480454
uniprot id: G1LLD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GGA1
gene id: 9646:GGA1
uniprot id: G1LU21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9646:SLC31A1
gene id: 9646:SLC31A1
uniprot id: D2H2J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9646:LOC100478110
gene id: 9646:LOC100478110
uniprot id: D2I0D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CIAO2A
gene id: 9646:CIAO2A
uniprot id: A0A7N5JZZ8
uniprot id: D2GYR1
names: Similarity
messages: Belongs to the MIP18 family.

9646:APOC2
gene id: 9646:APOC2
uniprot id: D2HPB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
messages: Secreted

9646:RPS4X
gene id: 9646:RPS4X
uniprot id: F2X203
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9646:MGP
gene id: 9646:MGP
uniprot id: G1LSP3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9646:LOC100483811
gene id: 9646:LOC100483811
uniprot id: D2GV81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9646:SUGP1
gene id: 9646:SUGP1
uniprot id: G1LZG2
names: Subcellular Location Annotation
messages: Nucleus

9646:KIF4A
gene id: 9646:KIF4A
uniprot id: D2H8A0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9646:FAM118B
gene id: 9646:FAM118B
uniprot id: A0A7N5JRU3
names: Similarity
messages: Belongs to the FAM118 family.

9646:JRKL
gene id: 9646:JRKL
uniprot id: D2HT46
names: Subcellular Location Annotation
messages: Nucleus

9646:NLRP3
gene id: 9646:NLRP3
uniprot id: D2I5A6
names: Similarity
messages: Belongs to the NLRP family.

9646:LEPROT
gene id: 9646:LEPROT
uniprot id: A0A7N5JWU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9646:TMCO1
gene id: 9646:TMCO1
uniprot id: A0A7N5KPJ0
uniprot id: D2GYK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload.
messages: Membrane

9646:GIPC2
gene id: 9646:GIPC2
uniprot id: D2HJ68
names: Similarity
messages: Belongs to the GIPC family.

9646:ANAPC13
gene id: 9646:ANAPC13
uniprot id: D2HTF7
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9646:DCTN4
gene id: 9646:DCTN4
uniprot id: D2H8L3
uniprot id: G1LCZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: cell cortex
messages: centrosome
messages: sarcomere
messages: stress fiber

9646:DLD
gene id: 9646:DLD
uniprot id: G1M5U2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

9646:CDC37
gene id: 9646:CDC37
uniprot id: G1LYI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9646:HNRNPA2B1
gene id: 9646:HNRNPA2B1
uniprot id: A0A7N5P0A5
uniprot id: G1LHD9
names: Subcellular Location Annotation
messages: Cytoplasmic granule

9646:ABCG4
gene id: 9646:ABCG4
uniprot id: D2I327
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9646:FGF5
gene id: 9646:FGF5
uniprot id: D2GUG1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9646:GMFB
gene id: 9646:GMFB
uniprot id: G1M9Y1
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9646:LSM3
gene id: 9646:LSM3
uniprot id: D2CMN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9646:CPA5
gene id: 9646:CPA5
uniprot id: G1LG08
names: Similarity
messages: Belongs to the peptidase M14 family.

9646:POT1
gene id: 9646:POT1
uniprot id: G1M977
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9646:PLOD2
gene id: 9646:PLOD2
uniprot id: G1M567
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9646:UFM1
gene id: 9646:UFM1
uniprot id: G1LG80
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9646:KLHL22
gene id: 9646:KLHL22
uniprot id: A0A805BFH7
names: Subcellular Location Annotation
messages: Lysosome
messages: Nucleus
messages: centrosome
messages: cytosol
messages: spindle

9646:SLC30A4
gene id: 9646:SLC30A4
uniprot id: D2HYJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9646:ADAM9
gene id: 9646:ADAM9
uniprot id: G1MA96
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:COPG1
gene id: 9646:COPG1
uniprot id: G1M9Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9646:THRSP
gene id: 9646:THRSP
uniprot id: G1MNK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9646:SF3B4
gene id: 9646:SF3B4
uniprot id: D2I4U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9646:PPARA
gene id: 9646:PPARA
uniprot id: D2HKK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
messages: Nucleus

9646:SLC16A7
gene id: 9646:SLC16A7
uniprot id: D2HND2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9646:STK38
gene id: 9646:STK38
uniprot id: D2GYV3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:MOSPD3
gene id: 9646:MOSPD3
uniprot id: D2HX09
names: Subcellular Location Annotation
messages: Membrane

9646:CHST11
gene id: 9646:CHST11
uniprot id: G1LJJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:TRIQK
gene id: 9646:TRIQK
uniprot id: A0A7N5P2Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIQK family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:CDK5R1
gene id: 9646:CDK5R1
uniprot id: D2GU65
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit and a regulatory subunit.
messages: Membrane

9646:C8G
gene id: 9646:C8G
uniprot id: G1M3X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9646:SSR1
gene id: 9646:SSR1
uniprot id: G1MGA8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9646:ERBB3
gene id: 9646:ERBB3
uniprot id: A0A7N5JLT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9646:HSBP1
gene id: 9646:HSBP1
uniprot id: G1LIR8
names: Similarity
messages: Belongs to the HSBP1 family.

9646:FGB
gene id: 9646:FGB
uniprot id: G1MJH9
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9646:CPLX4
gene id: 9646:CPLX4
uniprot id: D2HQF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9646:SVBP
gene id: 9646:SVBP
uniprot id: D2I2L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

9646:RRM2B
gene id: 9646:RRM2B
uniprot id: A0A7N5KCG7
uniprot id: G1M8P3
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

9646:EPGN
gene id: 9646:EPGN
uniprot id: G1M6Z4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:KRT79
gene id: 9646:KRT79
uniprot id: D2HLN6
names: Similarity
messages: Belongs to the intermediate filament family.

9646:PPIL3
gene id: 9646:PPIL3
uniprot id: G1LH44
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9646:CCN2
gene id: 9646:CCN2
uniprot id: D2HL25
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:FAM3A
gene id: 9646:FAM3A
uniprot id: G1L0H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9646:IPO7
gene id: 9646:IPO7
uniprot id: A0A7N5K7M3
names: Subcellular Location Annotation
messages: Cytoplasm

9646:KIFBP
gene id: 9646:KIFBP
uniprot id: D2GXI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

9646:SYNPR
gene id: 9646:SYNPR
uniprot id: A0A7N5KP15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9646:KCNJ16
gene id: 9646:KCNJ16
uniprot id: D2HP89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9646:ATRX
gene id: 9646:ATRX
uniprot id: G1L592
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9646:TNFSF15
gene id: 9646:TNFSF15
uniprot id: D2H2H8
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9646:TSHB
gene id: 9646:TSHB
uniprot id: D2HS26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9646:PLA2G1B
gene id: 9646:PLA2G1B
uniprot id: G1LF10
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9646:TMEM30A
gene id: 9646:TMEM30A
uniprot id: D2HSI0
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

9646:NCAPD2
gene id: 9646:NCAPD2
uniprot id: G1M779
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

9646:PELI1
gene id: 9646:PELI1
uniprot id: G1L2X3
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9646:FAM131A
gene id: 9646:FAM131A
uniprot id: A0A7N5P646
uniprot id: G1MFB9
names: Similarity
messages: Belongs to the FAM131 family.

9646:PTER
gene id: 9646:PTER
uniprot id: A0A7N5JQI0
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:NUCB2
gene id: 9646:NUCB2
uniprot id: G1L8F2
names: Similarity
messages: Belongs to the nucleobindin family.

9646:ERBIN
gene id: 9646:ERBIN
uniprot id: A0A7N5J8F6
uniprot id: A0A7N5JUT5
uniprot id: D2HBQ3
uniprot id: G1LXU9
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9646:CLEC16A
gene id: 9646:CLEC16A
uniprot id: A0A7N5KKW8
uniprot id: A0A7N5KQI6
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9646:GARS1
gene id: 9646:GARS1
uniprot id: G1LJD7
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

9646:MICOS10
gene id: 9646:MICOS10
uniprot id: A0A7N5JLY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9646:KIF3A
gene id: 9646:KIF3A
uniprot id: A0A7N5KK87
uniprot id: G1MHB0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9646:TIMM17A
gene id: 9646:TIMM17A
uniprot id: G1M008
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9646:KCNA6
gene id: 9646:KCNA6
uniprot id: D2HEJ3
names: Subcellular Location Annotation
messages: Membrane

9646:MAP2K5
gene id: 9646:MAP2K5
uniprot id: A0A7N5KQZ1
uniprot id: G1LEH9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:MCM6
gene id: 9646:MCM6
uniprot id: D2I516
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9646:ACSM5
gene id: 9646:ACSM5
uniprot id: G1LQP4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9646:APOE
gene id: 9646:APOE
uniprot id: D2HPB7
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9646:NAPSA
gene id: 9646:NAPSA
uniprot id: G1M3R7
names: Similarity
messages: Belongs to the peptidase A1 family.

9646:UGT8
gene id: 9646:UGT8
uniprot id: D2I2H6
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9646:ZMPSTE24
gene id: 9646:ZMPSTE24
uniprot id: A0A7N5K7V0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

9646:LOC100469119
gene id: 9646:LOC100469119
uniprot id: A0A7N5JV67
names: Subcellular Location Annotation
messages: Secreted

9646:GMDS
gene id: 9646:GMDS
uniprot id: G1LWN5
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9646:FGD3
gene id: 9646:FGD3
uniprot id: D2HXA5
names: Subcellular Location Annotation
messages: cytoskeleton

9646:LOC100465520
gene id: 9646:LOC100465520
uniprot id: D2HML1
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

9646:BOLA1
gene id: 9646:BOLA1
uniprot id: D2I4V0
names: Similarity
messages: Belongs to the BolA/IbaG family.

9646:SLC25A53
gene id: 9646:SLC25A53
uniprot id: G1MKP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:GPSM2
gene id: 9646:GPSM2
uniprot id: A0A7N5K3X3
names: Similarity
messages: Belongs to the GPSM family.

9646:MLLT11
gene id: 9646:MLLT11
uniprot id: D2HBT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9646:THOC5
gene id: 9646:THOC5
uniprot id: A0A7N5P252
uniprot id: G1LNK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9646:SEC13
gene id: 9646:SEC13
uniprot id: G1MC17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane

9646:FBXO9
gene id: 9646:FBXO9
uniprot id: G1LGL8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.

9646:STX19
gene id: 9646:STX19
uniprot id: A0A7N5KTB2
names: Similarity
messages: Belongs to the syntaxin family.

9646:GLUL
gene id: 9646:GLUL
uniprot id: D2HBW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Membrane
messages: Microsome
messages: Mitochondrion

9646:GCDH
gene id: 9646:GCDH
uniprot id: G1M176
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9646:LMOD3
gene id: 9646:LMOD3
uniprot id: G1LU65
names: Subcellular Location Annotation
messages: cytoskeleton

9646:MGME1
gene id: 9646:MGME1
uniprot id: G1LF86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGME1 family.
messages: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.
messages: Mitochondrion

9646:TGFA
gene id: 9646:TGFA
uniprot id: G1MBZ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:TTC4
gene id: 9646:TTC4
uniprot id: A0A7N5JPP0
uniprot id: G1LTM9
names: Similarity
messages: Belongs to the TTC4 family.

9646:LOC100482335
gene id: 9646:LOC100482335
uniprot id: G1L0I9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9646:PSMA1
gene id: 9646:PSMA1
uniprot id: A0A7N5JM49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9646:LOC100481510
gene id: 9646:LOC100481510
uniprot id: D2HIV3
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9646:CPLX2
gene id: 9646:CPLX2
uniprot id: D2HHT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9646:SRRD
gene id: 9646:SRRD
uniprot id: G1MIB3
names: Similarity
messages: Belongs to the SRR1 family.

9646:RPL24
gene id: 9646:RPL24
uniprot id: F2X267
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9646:TMEM167A
gene id: 9646:TMEM167A
uniprot id: A0A7N5KGT2
uniprot id: A0A7N5KRX1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:ARHGAP36
gene id: 9646:ARHGAP36
uniprot id: D2H9U0
names: Function
messages: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

9646:CDC26
gene id: 9646:CDC26
uniprot id: D2H2J3
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9646:TXNRD1
gene id: 9646:TXNRD1
uniprot id: A0A7N5KCL9
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

9646:CMKLR1
gene id: 9646:CMKLR1
uniprot id: G1MKF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9646:SNX19
gene id: 9646:SNX19
uniprot id: G1L5F4
names: Similarity
messages: Belongs to the sorting nexin family.

9646:TRAF3
gene id: 9646:TRAF3
uniprot id: D2HAH0
names: Subcellular Location Annotation
messages: Cytoplasm

9646:ST3GAL6
gene id: 9646:ST3GAL6
uniprot id: D2HSL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9646:GALNTL5
gene id: 9646:GALNTL5
uniprot id: G1M431
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Membrane

9646:FBXO32
gene id: 9646:FBXO32
uniprot id: D2HPI0
names: Subcellular Location Annotation
messages: Nucleus

9646:ACVRL1
gene id: 9646:ACVRL1
uniprot id: G1L4X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9646:SYT1
gene id: 9646:SYT1
uniprot id: D2H516
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

9646:KEG54 p11
gene id: 9646:KEG54_p11
uniprot id: A5JFJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9646:LOC100477562
gene id: 9646:LOC100477562
uniprot id: D2H9P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9646:MAN1C1
gene id: 9646:MAN1C1
uniprot id: G1LUP7
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9646:SPATS2L
gene id: 9646:SPATS2L
uniprot id: A0A7N5JTB2
names: Similarity
messages: Belongs to the SPATS2 family.

9646:HNRNPR
gene id: 9646:HNRNPR
uniprot id: D2GWC0
names: Subcellular Location Annotation
messages: Cytoplasm

9646:SFXN5
gene id: 9646:SFXN5
uniprot id: G1MAU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9646:EIF3E
gene id: 9646:EIF3E
uniprot id: G1M2D6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.

9646:PPP1CB
gene id: 9646:PPP1CB
uniprot id: G1LEU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9646:MAPK13
gene id: 9646:MAPK13
uniprot id: G1L0N5
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

9646:KATNAL1
gene id: 9646:KATNAL1
uniprot id: G1LQL6
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9646:MTMR3
gene id: 9646:MTMR3
uniprot id: A0A7N5JQV3
uniprot id: A0A7N5KBA9
uniprot id: A0A7N5P226
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9646:GRHL2
gene id: 9646:GRHL2
uniprot id: A0A7N5KIJ5
names: Subcellular Location Annotation
messages: Nucleus

9646:ZPR1
gene id: 9646:ZPR1
uniprot id: A0A7N5JEE9
uniprot id: D2HC81
names: Similarity
messages: Belongs to the ZPR1 family.

9646:DDOST
gene id: 9646:DDOST
uniprot id: G1L8D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

9646:OLFM3
gene id: 9646:OLFM3
uniprot id: A0A7N5P3F9
uniprot id: D2HAQ5
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9646:PDCL
gene id: 9646:PDCL
uniprot id: D2I6X7
names: Similarity
messages: Belongs to the phosducin family.

9646:IFNL3
gene id: 9646:IFNL3
uniprot id: D2HX83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9646:VPS53
gene id: 9646:VPS53
uniprot id: G1LNV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9646:LOC100473356
gene id: 9646:LOC100473356
uniprot id: A0A7N5K682
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane

9646:PPEF1
gene id: 9646:PPEF1
uniprot id: G1MEI5
names: Similarity
messages: Belongs to the PPP phosphatase family.

9646:SV2A
gene id: 9646:SV2A
uniprot id: D2I4U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9646:MCTS1
gene id: 9646:MCTS1
uniprot id: A0A7N5P0Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9646:CDR2
gene id: 9646:CDR2
uniprot id: D2HTZ8
names: Similarity
messages: Belongs to the CDR2 family.

9646:RUNX1T1
gene id: 9646:RUNX1T1
uniprot id: A0A7N5P2T3
uniprot id: G1LKJ2
uniprot id: G1LKK1
names: Similarity
messages: Belongs to the CBFA2T family.

9646:TSPAN5
gene id: 9646:TSPAN5
uniprot id: G1M5J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9646:PIH1D1
gene id: 9646:PIH1D1
uniprot id: G1M694
names: Similarity
messages: Belongs to the PIH1 family.

9646:MMP16
gene id: 9646:MMP16
uniprot id: G1MFI5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9646:DHPS
gene id: 9646:DHPS
uniprot id: D2HG03
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

9646:DPM3
gene id: 9646:DPM3
uniprot id: G1MKK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

9646:P2RX3
gene id: 9646:P2RX3
uniprot id: D2HK57
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9646:CAV2
gene id: 9646:CAV2
uniprot id: D2H6R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9646:GORAB
gene id: 9646:GORAB
uniprot id: G1LX89
names: Similarity
messages: Belongs to the GORAB family.

9646:THRB
gene id: 9646:THRB
uniprot id: D2HYY1
uniprot id: G1MI06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9646:CCR4
gene id: 9646:CCR4
uniprot id: D2HB03
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:LOC100483803
gene id: 9646:LOC100483803
uniprot id: A0A7N5KLS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:UBR1
gene id: 9646:UBR1
uniprot id: G1MB21
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9646:LBX2
gene id: 9646:LBX2
uniprot id: G1MFQ6
names: Subcellular Location Annotation
messages: Nucleus

9646:B3GNT5
gene id: 9646:B3GNT5
uniprot id: G1MNJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:LIPT1
gene id: 9646:LIPT1
uniprot id: D2HDD0
names: Similarity
messages: Belongs to the LplA family.

9646:EPHA3
gene id: 9646:EPHA3
uniprot id: G1LPI5
names: Subcellular Location Annotation
messages: Membrane

9646:MMP9
gene id: 9646:MMP9
uniprot id: D2HZ16
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

9646:ABCG2
gene id: 9646:ABCG2
uniprot id: A0A7N5K0F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9646:LOC100470062
gene id: 9646:LOC100470062
uniprot id: A0A7N5JAT8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9646:NELFE
gene id: 9646:NELFE
uniprot id: A0A7N5JZ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

9646:LOC100475526
gene id: 9646:LOC100475526
uniprot id: A0A7N5JHP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9646:TUBG1
gene id: 9646:TUBG1
uniprot id: D2HIU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9646:CUEDC2
gene id: 9646:CUEDC2
uniprot id: D2GXW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9646:AADAC
gene id: 9646:AADAC
uniprot id: D2H403
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9646:MC3R
gene id: 9646:MC3R
uniprot id: G1MMD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9646:RAMAC
gene id: 9646:RAMAC
uniprot id: D2I4M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAM family.
messages: Nucleus

9646:ZKSCAN5
gene id: 9646:ZKSCAN5
uniprot id: A0A7N5JPY3
names: Subcellular Location Annotation
messages: Nucleus

9646:CLDN19
gene id: 9646:CLDN19
uniprot id: D2I2L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9646:RNF103
gene id: 9646:RNF103
uniprot id: G1LTS2
names: Similarity
messages: Belongs to the SNF7 family.

9646:TWSG1
gene id: 9646:TWSG1
uniprot id: D2H764
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

9646:OGFOD1
gene id: 9646:OGFOD1
uniprot id: D2GTV6
names: Similarity
messages: Belongs to the TPA1 family.

9646:STK17B
gene id: 9646:STK17B
uniprot id: D2H630
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:TIMM10
gene id: 9646:TIMM10
uniprot id: D2CMN8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9646:C14H18orf21
gene id: 9646:C14H18orf21
uniprot id: D2HQD3
names: Similarity
messages: Belongs to the UPF0711 family.

9646:STMN1
gene id: 9646:STMN1
uniprot id: G1LUS1
names: Similarity
messages: Belongs to the stathmin family.

9646:SLC7A2
gene id: 9646:SLC7A2
uniprot id: G1M538
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9646:GCNT4
gene id: 9646:GCNT4
uniprot id: D2H684
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9646:CD40LG
gene id: 9646:CD40LG
uniprot id: D2HD93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface

9646:LOC100483558
gene id: 9646:LOC100483558
uniprot id: D2I7H0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9646:CAT
gene id: 9646:CAT
uniprot id: G1LN56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

9646:OCLN
gene id: 9646:OCLN
uniprot id: G1L979
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

9646:OGN
gene id: 9646:OGN
uniprot id: G1M4F9
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9646:ELP2
gene id: 9646:ELP2
uniprot id: D2HQD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

9646:CFAP94
gene id: 9646:CFAP94
uniprot id: A0A7N5KG46
uniprot id: A0A7N5KT02
names: Similarity
messages: Belongs to the DNAI7 family.

9646:SSBP2
gene id: 9646:SSBP2
uniprot id: A0A7N5P6Q4
uniprot id: G1MBU9
names: Subcellular Location Annotation
messages: Nucleus

9646:RFFL
gene id: 9646:RFFL
uniprot id: D2HMK7
names: Subcellular Location Annotation
messages: Cell membrane

9646:HOXA9
gene id: 9646:HOXA9
uniprot id: D2GVB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9646:LOC100464338
gene id: 9646:LOC100464338
uniprot id: D2HI71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:PNPLA4
gene id: 9646:PNPLA4
uniprot id: D2I355
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:TNFSF14
gene id: 9646:TNFSF14
uniprot id: D2HY81
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9646:CHD7
gene id: 9646:CHD7
uniprot id: D2H2C4
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9646:KCNAB1
gene id: 9646:KCNAB1
uniprot id: G1L8W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9646:GNB3
gene id: 9646:GNB3
uniprot id: G1M605
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9646:C1D
gene id: 9646:C1D
uniprot id: G1LDZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9646:TMEM237
gene id: 9646:TMEM237
uniprot id: G1M4A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9646:POLR2M
gene id: 9646:POLR2M
uniprot id: G1LVI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

9646:GSX2
gene id: 9646:GSX2
uniprot id: D2HBV5
names: Subcellular Location Annotation
messages: Nucleus

9646:LYRM2
gene id: 9646:LYRM2
uniprot id: G1L149
names: Similarity
messages: Belongs to the complex I LYR family.

9646:CDNF
gene id: 9646:CDNF
uniprot id: D2I3V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9646:PAM16
gene id: 9646:PAM16
uniprot id: A0A7N5JMS5
names: Similarity
messages: Belongs to the TIM16/PAM16 family.

9646:USE1
gene id: 9646:USE1
uniprot id: A0A7N5JFZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:PVALB
gene id: 9646:PVALB
uniprot id: G1LT07
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9646:GPN2
gene id: 9646:GPN2
uniprot id: A0A7N5KHJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9646:LOC100466453
gene id: 9646:LOC100466453
uniprot id: D2I678
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:ATP6V1B2
gene id: 9646:ATP6V1B2
uniprot id: D2I2A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9646:ENTPD4
gene id: 9646:ENTPD4
uniprot id: G1L833
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9646:NCL
gene id: 9646:NCL
uniprot id: G1MD31
names: Function
names: Subcellular Location Annotation
messages: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
messages: nucleolus

9646:FTL
gene id: 9646:FTL
uniprot id: D2H7X8
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9646:DDX59
gene id: 9646:DDX59
uniprot id: D2GZP4
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.

9646:HSPB3
gene id: 9646:HSPB3
uniprot id: D2HXE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Nucleus

9646:FAM98C
gene id: 9646:FAM98C
uniprot id: D2HTH2
names: Similarity
messages: Belongs to the FAM98 family.

9646:JPT1
gene id: 9646:JPT1
uniprot id: G1LRG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9646:ILDR1
gene id: 9646:ILDR1
uniprot id: G1M6Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9646:HNF1B
gene id: 9646:HNF1B
uniprot id: A0A7N5K4F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9646:LOC100475355
gene id: 9646:LOC100475355
uniprot id: A0A7N5JG13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CCT8
gene id: 9646:CCT8
uniprot id: A0A7N5JFQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

9646:PICALM
gene id: 9646:PICALM
uniprot id: A0A7N5J857
uniprot id: A0A7N5KG26
uniprot id: A0A7N5KGZ1
uniprot id: A0A7N5KSW6
uniprot id: G1LQC0
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9646:LOC100482027
gene id: 9646:LOC100482027
uniprot id: A0A7N5KH24
names: Similarity
messages: Belongs to the globin family.

9646:RPL28
gene id: 9646:RPL28
uniprot id: D2HUW2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

9646:SMPD2
gene id: 9646:SMPD2
uniprot id: D2HT00
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9646:NTRK3
gene id: 9646:NTRK3
uniprot id: A0A7N5JW29
uniprot id: A0A7N5KDU3
uniprot id: G1M275
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

9646:RXRB
gene id: 9646:RXRB
uniprot id: D2GZ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9646:AMIGO1
gene id: 9646:AMIGO1
uniprot id: D2HBH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9646:LOC100471731
gene id: 9646:LOC100471731
uniprot id: D2I6T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CPSF6
gene id: 9646:CPSF6
uniprot id: G1LZA1
uniprot id: G1LZA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

9646:MSH4
gene id: 9646:MSH4
uniprot id: G1LAB4
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9646:SLC35E4
gene id: 9646:SLC35E4
uniprot id: D2H215
names: Subcellular Location Annotation
messages: Membrane

9646:TMEM161A
gene id: 9646:TMEM161A
uniprot id: G1LYX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9646:KEG54 p10
gene id: 9646:KEG54_p10
uniprot id: A0A1I9WA83
uniprot id: Q2Y0B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9646:RASGRP3
gene id: 9646:RASGRP3
uniprot id: G1LMK1
names: Similarity
messages: Belongs to the RASGRP family.

9646:ARPC1A
gene id: 9646:ARPC1A
uniprot id: G1LI97
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

9646:EXOC4
gene id: 9646:EXOC4
uniprot id: G1MEJ2
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9646:LOC100477935
gene id: 9646:LOC100477935
uniprot id: D2HZE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:NAPA
gene id: 9646:NAPA
uniprot id: G1LND3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9646:GFRA2
gene id: 9646:GFRA2
uniprot id: G1LAJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

9646:IL6ST
gene id: 9646:IL6ST
uniprot id: G1LAB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9646:SERINC3
gene id: 9646:SERINC3
uniprot id: G1LBG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9646:NTS
gene id: 9646:NTS
uniprot id: A0A7N5KHN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9646:TADA2A
gene id: 9646:TADA2A
uniprot id: G1M3Q5
names: Subcellular Location Annotation
messages: Nucleus

9646:SMC3
gene id: 9646:SMC3
uniprot id: G1MB71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

9646:LOC100467415
gene id: 9646:LOC100467415
uniprot id: D2HED0
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100475793
gene id: 9646:LOC100475793
uniprot id: A0A7N5PAE7
uniprot id: G1M1D5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9646:LOC109490354
gene id: 9646:LOC109490354
uniprot id: G1MLE5
names: Similarity
messages: Belongs to the TTC39 family.

9646:SLC25A30
gene id: 9646:SLC25A30
uniprot id: A0A7N5JTH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:PGK2
gene id: 9646:PGK2
uniprot id: D2H1P3
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9646:CNOT8
gene id: 9646:CNOT8
uniprot id: D2H634
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9646:ELMO1
gene id: 9646:ELMO1
uniprot id: G1MII8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9646:NIM1K
gene id: 9646:NIM1K
uniprot id: D2HHQ9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:PSMD11
gene id: 9646:PSMD11
uniprot id: D2GU64
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

9646:IFT57
gene id: 9646:IFT57
uniprot id: D2HVA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9646:TLX2
gene id: 9646:TLX2
uniprot id: D2HH56
names: Subcellular Location Annotation
messages: Nucleus

9646:PGD
gene id: 9646:PGD
uniprot id: G1LJK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9646:MRPL32
gene id: 9646:MRPL32
uniprot id: D2HM12
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9646:ABCB8
gene id: 9646:ABCB8
uniprot id: A0A7N5JBM3
uniprot id: G1M5L5
names: Subcellular Location Annotation
messages: Membrane

9646:RPS24
gene id: 9646:RPS24
uniprot id: A0A7N5JML7
uniprot id: A0A7N5JQF2
uniprot id: A0A7N5KJX1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

9646:AIDA
gene id: 9646:AIDA
uniprot id: D2GYL3
names: Similarity
messages: Belongs to the AIDA family.

9646:MYLK2
gene id: 9646:MYLK2
uniprot id: G1M4Y3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May interact with centrin.

9646:PHKG2
gene id: 9646:PHKG2
uniprot id: D2HQN8
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9646:ANXA7
gene id: 9646:ANXA7
uniprot id: G1MEU2
uniprot id: G1MEU5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9646:PKIA
gene id: 9646:PKIA
uniprot id: A0A7N5KHH1
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9646:RHPN2
gene id: 9646:RHPN2
uniprot id: G1MAP5
names: Similarity
messages: Belongs to the RHPN family.

9646:ATF1
gene id: 9646:ATF1
uniprot id: A0A7N5KGL8
names: Subcellular Location Annotation
messages: Nucleus

9646:RPS20
gene id: 9646:RPS20
uniprot id: E4W6Z3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

9646:CLEC12B
gene id: 9646:CLEC12B
uniprot id: D2HS34
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:MRPL4
gene id: 9646:MRPL4
uniprot id: D2HGZ5
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

9646:SNX5
gene id: 9646:SNX5
uniprot id: G1LFA9
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9646:MRPS9
gene id: 9646:MRPS9
uniprot id: D2GWY2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9646:AQP4
gene id: 9646:AQP4
uniprot id: G1M6L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9646:NAGK
gene id: 9646:NAGK
uniprot id: G1MBI6
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9646:CDCA2
gene id: 9646:CDCA2
uniprot id: D2GZ78
names: Subcellular Location Annotation
messages: Nucleus

9646:CADM4
gene id: 9646:CADM4
uniprot id: G1LC94
names: Similarity
messages: Belongs to the nectin family.

9646:LOC100466776
gene id: 9646:LOC100466776
uniprot id: G1LGC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9646:RRAGD
gene id: 9646:RRAGD
uniprot id: G1L106
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9646:HSDL1
gene id: 9646:HSDL1
uniprot id: D2HRI3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:PLA2G4F
gene id: 9646:PLA2G4F
uniprot id: G1MCX9
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9646:GAMT
gene id: 9646:GAMT
uniprot id: G1L9G0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.
messages: Monomer.

9646:KIN
gene id: 9646:KIN
uniprot id: G1LTR1
names: Similarity
messages: Belongs to the KIN17 family.

9646:INO80D
gene id: 9646:INO80D
uniprot id: A0A7N5JD86
names: Subcellular Location Annotation
messages: Nucleus

9646:TAF6
gene id: 9646:TAF6
uniprot id: D2I5E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9646:LOC100465033
gene id: 9646:LOC100465033
uniprot id: D2I0N1
names: Similarity
messages: Belongs to the PRR23 family.

9646:GPER1
gene id: 9646:GPER1
uniprot id: G1MP46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:MID2
gene id: 9646:MID2
uniprot id: G1L7V9
names: Subcellular Location Annotation
messages: cytoskeleton

9646:LOC100467386
gene id: 9646:LOC100467386
uniprot id: D2I7P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:MRPL44
gene id: 9646:MRPL44
uniprot id: D2H9R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

9646:ACTRT3
gene id: 9646:ACTRT3
uniprot id: D2H6S0
names: Similarity
messages: Belongs to the actin family.

9646:TXNL4A
gene id: 9646:TXNL4A
uniprot id: D2HED5
names: Similarity
messages: Belongs to the DIM1 family.

9646:SLC26A9
gene id: 9646:SLC26A9
uniprot id: A0A7N5KDC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane.
messages: Membrane

9646:SPIB
gene id: 9646:SPIB
uniprot id: A0A7N5JZ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9646:DPAGT1
gene id: 9646:DPAGT1
uniprot id: D2I329
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:PEX5
gene id: 9646:PEX5
uniprot id: D2HIZ3
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9646:UROS
gene id: 9646:UROS
uniprot id: D2H3F0
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9646:HPDL
gene id: 9646:HPDL
uniprot id: D2HC33
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9646:CXCR4
gene id: 9646:CXCR4
uniprot id: G1MLH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell junction
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Membrane

9646:VCL
gene id: 9646:VCL
uniprot id: D2HEE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: podosome

9646:CLCC1
gene id: 9646:CLCC1
uniprot id: D2HBG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane

9646:PCNA
gene id: 9646:PCNA
uniprot id: D2HQS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9646:C4H2orf68
gene id: 9646:C4H2orf68
uniprot id: D2HKM8
names: Similarity
messages: Belongs to the UPF0561 family.

9646:BTF3L4
gene id: 9646:BTF3L4
uniprot id: G1LRE7
names: Similarity
messages: Belongs to the NAC-beta family.

9646:INTS9
gene id: 9646:INTS9
uniprot id: A0A7N5JW83
uniprot id: G1MC36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

9646:TRIM32
gene id: 9646:TRIM32
uniprot id: G1MMT5
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9646:CNTF
gene id: 9646:CNTF
uniprot id: D2HZE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

9646:PKP2
gene id: 9646:PKP2
uniprot id: A0A7N5K6Q7
names: Similarity
messages: Belongs to the beta-catenin family.

9646:CLTA
gene id: 9646:CLTA
uniprot id: G1LTW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9646:FMO4
gene id: 9646:FMO4
uniprot id: D2I020
names: Similarity
messages: Belongs to the FMO family.

9646:KCNMB4
gene id: 9646:KCNMB4
uniprot id: D2HIW6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9646:CRKL
gene id: 9646:CRKL
uniprot id: D2HUK7
names: Similarity
messages: Belongs to the CRK family.

9646:TET2
gene id: 9646:TET2
uniprot id: G1LJZ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9646:FAM221A
gene id: 9646:FAM221A
uniprot id: A0A7N5J8I0
names: Similarity
messages: Belongs to the FAM221 family.

9646:ACLY
gene id: 9646:ACLY
uniprot id: G1LGZ5
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9646:ASPHD1
gene id: 9646:ASPHD1
uniprot id: G1M913
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9646:SULT2B1
gene id: 9646:SULT2B1
uniprot id: G1M8P2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9646:EDC3
gene id: 9646:EDC3
uniprot id: D2HKY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9646:NDUFS5
gene id: 9646:NDUFS5
uniprot id: D2HXG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9646:CD3E
gene id: 9646:CD3E
uniprot id: G1M3G6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:SCG5
gene id: 9646:SCG5
uniprot id: D2H7R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9646:NBN
gene id: 9646:NBN
uniprot id: G1M943
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
messages: Component of the MRN complex.
messages: Nucleus
messages: telomere

9646:HOXC11
gene id: 9646:HOXC11
uniprot id: D2HM43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9646:URM1
gene id: 9646:URM1
uniprot id: G1MAC0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

9646:PUS3
gene id: 9646:PUS3
uniprot id: G1KZV9
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9646:ATP6V0A4
gene id: 9646:ATP6V0A4
uniprot id: D2GYN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9646:PTGR2
gene id: 9646:PTGR2
uniprot id: G1MIT3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9646:PSMA2
gene id: 9646:PSMA2
uniprot id: G1LS94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9646:MSTN
gene id: 9646:MSTN
uniprot id: D2HA19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted

9646:ADCK1
gene id: 9646:ADCK1
uniprot id: A0A7N5P0N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Secreted

9646:C4H19orf53
gene id: 9646:C4H19orf53
uniprot id: D2HFY2
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9646:LEAP2
gene id: 9646:LEAP2
uniprot id: G1MHC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9646:LOC109491003
gene id: 9646:LOC109491003
uniprot id: A0A7N5KC20
names: Subcellular Location Annotation
messages: Cytoplasm

9646:SSR4
gene id: 9646:SSR4
uniprot id: G1MJI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9646:ATP10D
gene id: 9646:ATP10D
uniprot id: D2H5N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9646:BRCC3
gene id: 9646:BRCC3
uniprot id: G1LZT1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9646:AKT3
gene id: 9646:AKT3
uniprot id: G1LRV9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9646:ZFPL1
gene id: 9646:ZFPL1
uniprot id: G1MH70
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

9646:LOC100477520
gene id: 9646:LOC100477520
uniprot id: D2I7L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CCL21
gene id: 9646:CCL21
uniprot id: A0A7N5JAC2
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9646:S1PR3
gene id: 9646:S1PR3
uniprot id: G1MNK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:VKORC1
gene id: 9646:VKORC1
uniprot id: D2HQM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:EXOSC3
gene id: 9646:EXOSC3
uniprot id: D2H0I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm
messages: nucleolus

9646:NR5A2
gene id: 9646:NR5A2
uniprot id: A0A7N5JJM9
uniprot id: G1M1X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9646:UTS2B
gene id: 9646:UTS2B
uniprot id: G1LYL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9646:ARL2BP
gene id: 9646:ARL2BP
uniprot id: G1MEW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9646:RPS21
gene id: 9646:RPS21
uniprot id: F2X220
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

9646:NFYB
gene id: 9646:NFYB
uniprot id: A0A7N5P6U4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9646:TBC1D23
gene id: 9646:TBC1D23
uniprot id: G1LBJ3
uniprot id: G1LBJ7
names: Subcellular Location Annotation
messages: trans-Golgi network

9646:CALHM3
gene id: 9646:CALHM3
uniprot id: D2GXY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9646:MRPL54
gene id: 9646:MRPL54
uniprot id: A0A7N5KDD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9646:MMP7
gene id: 9646:MMP7
uniprot id: G1LU30
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9646:MUL1
gene id: 9646:MUL1
uniprot id: D2H287
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100467636
gene id: 9646:LOC100467636
uniprot id: D2I7P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:APCS
gene id: 9646:APCS
uniprot id: A0A7N5KKF6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9646:LOC100482898
gene id: 9646:LOC100482898
uniprot id: D2I6Q2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:SLC25A35
gene id: 9646:SLC25A35
uniprot id: A0A7N5JWB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:ATP23
gene id: 9646:ATP23
uniprot id: D2H327
names: Similarity
messages: Belongs to the peptidase M76 family.

9646:ITM2A
gene id: 9646:ITM2A
uniprot id: D2I1H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9646:CLDN4
gene id: 9646:CLDN4
uniprot id: D2HMA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9646:ATXN7L3
gene id: 9646:ATXN7L3
uniprot id: G1MJ46
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.
messages: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

9646:SLC30A7
gene id: 9646:SLC30A7
uniprot id: G1LSW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9646:SYNDIG1L
gene id: 9646:SYNDIG1L
uniprot id: D2GZW7
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9646:SLC16A6
gene id: 9646:SLC16A6
uniprot id: D2HSY3
names: Subcellular Location Annotation
messages: Membrane

9646:WARS2
gene id: 9646:WARS2
uniprot id: G1LNE9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9646:C11H1orf158
gene id: 9646:C11H1orf158
uniprot id: A0A7N5KD43
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

9646:CCNH
gene id: 9646:CCNH
uniprot id: G1M3Z9
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9646:SCNM1
gene id: 9646:SCNM1
uniprot id: G1L251
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: nucleoplasm

9646:SLC39A10
gene id: 9646:SLC39A10
uniprot id: D2H628
names: Subcellular Location Annotation
messages: Membrane

9646:CD2
gene id: 9646:CD2
uniprot id: D2HMI8
names: Subcellular Location Annotation
messages: Membrane

9646:SMC5
gene id: 9646:SMC5
uniprot id: G1LKK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

9646:DSEL
gene id: 9646:DSEL
uniprot id: G1MLL3
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9646:LPCAT2
gene id: 9646:LPCAT2
uniprot id: D2GTV1
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9646:MTHFD1
gene id: 9646:MTHFD1
uniprot id: G1LB74
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9646:C8H11orf54
gene id: 9646:C8H11orf54
uniprot id: G1M2K4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9646:IMP3
gene id: 9646:IMP3
uniprot id: D2HRJ9
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9646:SERPIND1
gene id: 9646:SERPIND1
uniprot id: D2HUL0
names: Similarity
messages: Belongs to the serpin family.

9646:PADI2
gene id: 9646:PADI2
uniprot id: D2HNM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Cytoplasm

9646:POPDC2
gene id: 9646:POPDC2
uniprot id: A0A7N5P633
uniprot id: G1LKR1
uniprot id: G1LKR7
names: Similarity
messages: Belongs to the popeye family.

9646:MAF1
gene id: 9646:MAF1
uniprot id: D2HIN6
names: Similarity
messages: Belongs to the MAF1 family.

9646:LOC100479471
gene id: 9646:LOC100479471
uniprot id: D2H193
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9646:PRKG2
gene id: 9646:PRKG2
uniprot id: A0A7N5KKI2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9646:LOC100469018
gene id: 9646:LOC100469018
uniprot id: A0A7N5P2R2
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:RAB3B
gene id: 9646:RAB3B
uniprot id: D2H2D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9646:ARMT1
gene id: 9646:ARMT1
uniprot id: A0A7N5P3G6
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9646:LHX8
gene id: 9646:LHX8
uniprot id: G1L9U3
names: Subcellular Location Annotation
messages: Nucleus

9646:SLC39A6
gene id: 9646:SLC39A6
uniprot id: D2HQD5
names: Subcellular Location Annotation
messages: Membrane

9646:LOC100476320
gene id: 9646:LOC100476320
uniprot id: D2HKT3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GPX8
gene id: 9646:GPX8
uniprot id: D2I0X9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9646:ZHX1
gene id: 9646:ZHX1
uniprot id: D2HPH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9646:WDR44
gene id: 9646:WDR44
uniprot id: D2H3B6
names: Subcellular Location Annotation
messages: trans-Golgi network

9646:LOC100481385
gene id: 9646:LOC100481385
uniprot id: D2I2N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9646:CANT1
gene id: 9646:CANT1
uniprot id: A0A7N5KMJ3
uniprot id: D2H9A9
names: Similarity
messages: Belongs to the apyrase family.

9646:ATP5MC3
gene id: 9646:ATP5MC3
uniprot id: G1M112
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9646:SLC39A5
gene id: 9646:SLC39A5
uniprot id: D2H349
names: Subcellular Location Annotation
messages: Membrane

9646:MRPL33
gene id: 9646:MRPL33
uniprot id: G1L2V1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9646:MEIS1
gene id: 9646:MEIS1
uniprot id: A0A7N5K5M7
uniprot id: G1MBB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9646:PGM1
gene id: 9646:PGM1
uniprot id: G1M967
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9646:FBXO25
gene id: 9646:FBXO25
uniprot id: D2I1A0
uniprot id: G1M8P9
names: Subcellular Location Annotation
messages: Nucleus

9646:RMI1
gene id: 9646:RMI1
uniprot id: G1MM83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9646:LOC100480698
gene id: 9646:LOC100480698
uniprot id: D2HRC7
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

9646:TALDO1
gene id: 9646:TALDO1
uniprot id: D2I730
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

9646:CHML
gene id: 9646:CHML
uniprot id: D2H9H4
names: Similarity
messages: Belongs to the Rab GDI family.

9646:SLC25A15
gene id: 9646:SLC25A15
uniprot id: G1LZ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:IPO9
gene id: 9646:IPO9
uniprot id: G1M063
names: Subcellular Location Annotation
messages: Cytoplasm

9646:DPH2
gene id: 9646:DPH2
uniprot id: G1L2Q9
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

9646:TMEFF2
gene id: 9646:TMEFF2
uniprot id: G1M6W2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:MAT2B
gene id: 9646:MAT2B
uniprot id: A0A7N5JLL9
uniprot id: G1LF26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9646:GDF9
gene id: 9646:GDF9
uniprot id: C5HV43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9646:FAM219A
gene id: 9646:FAM219A
uniprot id: A0A7N5KLD5
names: Similarity
messages: Belongs to the FAM219 family.

9646:BRPF1
gene id: 9646:BRPF1
uniprot id: A0A7N5K8J2
uniprot id: D2HRB1
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100472384
gene id: 9646:LOC100472384
uniprot id: D2HU89
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9646:TAF1A
gene id: 9646:TAF1A
uniprot id: G1LK10
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9646:TMEM192
gene id: 9646:TMEM192
uniprot id: G1LG02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

9646:CAPN7
gene id: 9646:CAPN7
uniprot id: D2H1G2
names: Similarity
messages: Belongs to the peptidase C2 family.

9646:DCTN1
gene id: 9646:DCTN1
uniprot id: A0A7N5P277
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

9646:SPSB1
gene id: 9646:SPSB1
uniprot id: D2HA29
names: Similarity
messages: Belongs to the SPSB family.

9646:CHGA
gene id: 9646:CHGA
uniprot id: G1M4X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9646:EFHC2
gene id: 9646:EFHC2
uniprot id: G1MGP4
names: Subcellular Location Annotation
messages: cilium axoneme

9646:C8H1orf43
gene id: 9646:C8H1orf43
uniprot id: D2HJP2
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

9646:GNB4
gene id: 9646:GNB4
uniprot id: G1LWF1
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9646:RPLP1
gene id: 9646:RPLP1
uniprot id: A9XSS6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9646:CERS3
gene id: 9646:CERS3
uniprot id: G1M7E0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9646:BET1
gene id: 9646:BET1
uniprot id: A0A7N5JSZ4
names: Subcellular Location Annotation
messages: Membrane

9646:KAT7
gene id: 9646:KAT7
uniprot id: G1M0R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9646:LOC100467668
gene id: 9646:LOC100467668
uniprot id: A0A7N5JCX3
uniprot id: A0A7N5KHI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9646:SLC9A4
gene id: 9646:SLC9A4
uniprot id: D2GWX7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9646:KIF20A
gene id: 9646:KIF20A
uniprot id: D2HK91
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9646:YOD1
gene id: 9646:YOD1
uniprot id: D2I0M3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

9646:RABGGTA
gene id: 9646:RABGGTA
uniprot id: G1MCH3
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

9646:PPP1R10
gene id: 9646:PPP1R10
uniprot id: D2I133
uniprot id: G1M3W3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

9646:GPC3
gene id: 9646:GPC3
uniprot id: A0A7N5P7E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9646:LOC100464344
gene id: 9646:LOC100464344
uniprot id: D2HL27
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:NEU1
gene id: 9646:NEU1
uniprot id: D2I745
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9646:AZIN2
gene id: 9646:AZIN2
uniprot id: G1LLE6
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9646:DOK3
gene id: 9646:DOK3
uniprot id: G1MIA8
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9646:NUMB
gene id: 9646:NUMB
uniprot id: A0A7N5KL10
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9646:LOC100479982
gene id: 9646:LOC100479982
uniprot id: G1M2B6
names: Similarity
messages: Belongs to the SSX family.

9646:PSMD1
gene id: 9646:PSMD1
uniprot id: G1MDC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9646:CAMK2N2
gene id: 9646:CAMK2N2
uniprot id: G1MFM6
names: Similarity
messages: Belongs to the CAMK2N family.

9646:GPR119
gene id: 9646:GPR119
uniprot id: D2H9U6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:KEG54 p04
gene id: 9646:KEG54_p04
uniprot id: A5JFK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion membrane

9646:KEG54 p01
gene id: 9646:KEG54_p01
uniprot id: Q33784
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

9646:LOC100478013
gene id: 9646:LOC100478013
uniprot id: G1L290
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:KRT23
gene id: 9646:KRT23
uniprot id: G1LP05
names: Similarity
messages: Belongs to the intermediate filament family.

9646:PDE4A
gene id: 9646:PDE4A
uniprot id: A0A7N5JBH8
uniprot id: A0A7N5JLU8
uniprot id: G1LYH1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9646:FAM234B
gene id: 9646:FAM234B
uniprot id: G1LW18
names: Similarity
messages: Belongs to the FAM234 family.

9646:RPE65
gene id: 9646:RPE65
uniprot id: G1L0Y3
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

9646:MC2R
gene id: 9646:MC2R
uniprot id: G1MLV3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane

9646:TPT1
gene id: 9646:TPT1
uniprot id: A0A7N5KLB3
names: Similarity
messages: Belongs to the TCTP family.

9646:NXT1
gene id: 9646:NXT1
uniprot id: D2HSG8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9646:STARD6
gene id: 9646:STARD6
uniprot id: G1MFM4
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9646:IL10
gene id: 9646:IL10
uniprot id: G1MGJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-10 family.
messages: Homodimer. Interacts with IL10RA and IL10RB.
messages: Immune regulatory cytokine.
messages: Secreted

9646:RECQL
gene id: 9646:RECQL
uniprot id: A0A7N5JIQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9646:C3AR1
gene id: 9646:C3AR1
uniprot id: G1ML29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9646:SUPV3L1
gene id: 9646:SUPV3L1
uniprot id: D2GXI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9646:OAZ2
gene id: 9646:OAZ2
uniprot id: A0A7N5P2S4
names: Similarity
messages: Belongs to the ODC antizyme family.

9646:PIK3CG
gene id: 9646:PIK3CG
uniprot id: D2GX94
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9646:FMO1
gene id: 9646:FMO1
uniprot id: A0A7N5JKA6
uniprot id: D2I021
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:NAA60
gene id: 9646:NAA60
uniprot id: A0A7N5J9Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane

9646:LOC100479209
gene id: 9646:LOC100479209
uniprot id: G1M3H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:MRPS25
gene id: 9646:MRPS25
uniprot id: D2HGM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9646:KEG54 p03
gene id: 9646:KEG54_p03
uniprot id: A5JFK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9646:MDH1
gene id: 9646:MDH1
uniprot id: G1LFQ4
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

9646:TXLNA
gene id: 9646:TXLNA
uniprot id: D2HI61
names: Similarity
messages: Belongs to the taxilin family.

9646:ERBB2
gene id: 9646:ERBB2
uniprot id: A0A7N5K3C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9646:GART
gene id: 9646:GART
uniprot id: D2HCF9
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

9646:PIGO
gene id: 9646:PIGO
uniprot id: D2I1Z6
uniprot id: G1MAI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:ASB17
gene id: 9646:ASB17
uniprot id: G1LAB7
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9646:CLTC
gene id: 9646:CLTC
uniprot id: A0A7N5P1W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9646:TBL1XR1
gene id: 9646:TBL1XR1
uniprot id: A0A7N5K9A2
names: Similarity
messages: Belongs to the WD repeat EBI family.

9646:TPR
gene id: 9646:TPR
uniprot id: G1MAI0
names: Similarity
messages: Belongs to the TPR family.

9646:C9
gene id: 9646:C9
uniprot id: A0A7N5K551
uniprot id: G1MFD4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:CPPED1
gene id: 9646:CPPED1
uniprot id: G1LXY1
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

9646:MAGT1
gene id: 9646:MAGT1
uniprot id: G1LHS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:HSD17B4
gene id: 9646:HSD17B4
uniprot id: A0A7N5P1M9
names: Subcellular Location Annotation
messages: Peroxisome

9646:GTF2H5
gene id: 9646:GTF2H5
uniprot id: A0A7N5K323
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

9646:LOC100479359
gene id: 9646:LOC100479359
uniprot id: D2HP45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:SEC24A
gene id: 9646:SEC24A
uniprot id: D2GVJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9646:LOC100476859
gene id: 9646:LOC100476859
uniprot id: D2I5D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TNP2
gene id: 9646:TNP2
uniprot id: A0A7N5KGS7
names: Similarity
messages: Belongs to the nuclear transition protein 2 family.

9646:ASPA
gene id: 9646:ASPA
uniprot id: D2HZN6
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9646:LOC100468148
gene id: 9646:LOC100468148
uniprot id: D2H0T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9646:RC3H1
gene id: 9646:RC3H1
uniprot id: D2H5I4
names: Subcellular Location Annotation
messages: P-body

9646:UFD1
gene id: 9646:UFD1
uniprot id: G1LY74
names: Similarity
messages: Belongs to the UFD1 family.

9646:VARS2
gene id: 9646:VARS2
uniprot id: G1M340
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9646:OTC
gene id: 9646:OTC
uniprot id: G1LKR6
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9646:CAMK2N1
gene id: 9646:CAMK2N1
uniprot id: G1L953
names: Similarity
messages: Belongs to the CAMK2N family.

9646:TMA16
gene id: 9646:TMA16
uniprot id: G1L2U3
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9646:MSL3
gene id: 9646:MSL3
uniprot id: A0A7N5P853
names: Subcellular Location Annotation
messages: Nucleus

9646:RPL27
gene id: 9646:RPL27
uniprot id: G1L014
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9646:RPS6KB1
gene id: 9646:RPS6KB1
uniprot id: A0A7N5KAV6
uniprot id: D2HLU3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9646:RPL17
gene id: 9646:RPL17
uniprot id: F2X254
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9646:HCAR2
gene id: 9646:HCAR2
uniprot id: G1MMR8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:NAF1
gene id: 9646:NAF1
uniprot id: D2HXK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

9646:KCNA1
gene id: 9646:KCNA1
uniprot id: D2HEJ2
names: Subcellular Location Annotation
messages: Membrane

9646:B3GALNT1
gene id: 9646:B3GALNT1
uniprot id: D2HVY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:CCDC172
gene id: 9646:CCDC172
uniprot id: G1M5P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

9646:LOC100471180
gene id: 9646:LOC100471180
uniprot id: G1M606
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9646:TBX20
gene id: 9646:TBX20
uniprot id: D2HA06
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9646:SERPINF1
gene id: 9646:SERPINF1
uniprot id: G1LML8
names: Similarity
messages: Belongs to the serpin family.

9646:COPS7B
gene id: 9646:COPS7B
uniprot id: A0A7N5KQL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9646:VCP
gene id: 9646:VCP
uniprot id: G1MAF6
names: Similarity
messages: Belongs to the AAA ATPase family.

9646:PTPN3
gene id: 9646:PTPN3
uniprot id: A0A7N5K725
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9646:SNX3
gene id: 9646:SNX3
uniprot id: D2H6J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

9646:TIGD4
gene id: 9646:TIGD4
uniprot id: G1MLG7
names: Subcellular Location Annotation
messages: Nucleus

9646:UBE2L3
gene id: 9646:UBE2L3
uniprot id: A0A7N5KEP5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9646:CASD1
gene id: 9646:CASD1
uniprot id: D2H8U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

9646:ST8SIA5
gene id: 9646:ST8SIA5
uniprot id: A0A7N5KKL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9646:UTP25
gene id: 9646:UTP25
uniprot id: D2HIJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9646:RPSA
gene id: 9646:RPSA
uniprot id: D2HZN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cytoplasm

9646:MRPL13
gene id: 9646:MRPL13
uniprot id: G1L619
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9646:USP15
gene id: 9646:USP15
uniprot id: A0A7N5KL11
uniprot id: D2HCH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9646:MRPL46
gene id: 9646:MRPL46
uniprot id: D2HCD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

9646:ADAMTS15
gene id: 9646:ADAMTS15
uniprot id: D2GUW8
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9646:GDF2
gene id: 9646:GDF2
uniprot id: D2I4F5
names: Similarity
messages: Belongs to the TGF-beta family.

9646:EIF5A2
gene id: 9646:EIF5A2
uniprot id: A0A7N5JS63
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

9646:NFXL1
gene id: 9646:NFXL1
uniprot id: G1L963
names: Similarity
messages: Belongs to the NFX1 family.

9646:RFX3
gene id: 9646:RFX3
uniprot id: G1M0E9
names: Subcellular Location Annotation
messages: Nucleus

9646:PAIP2B
gene id: 9646:PAIP2B
uniprot id: G1MBG4
names: Similarity
messages: Belongs to the PAIP2 family.

9646:CDK4
gene id: 9646:CDK4
uniprot id: D2H394
names: Similarity
messages: Belongs to the protein kinase superfamily.

9646:C5
gene id: 9646:C5
uniprot id: G1L2Q2
names: Subcellular Location Annotation
messages: Secreted

9646:CNEP1R1
gene id: 9646:CNEP1R1
uniprot id: G1LIS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9646:SNAP23
gene id: 9646:SNAP23
uniprot id: G1MBC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9646:SERPINC1
gene id: 9646:SERPINC1
uniprot id: G1MAY6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

9646:MAGI3
gene id: 9646:MAGI3
uniprot id: G1L9K5
names: Subcellular Location Annotation
messages: Membrane

9646:SRD5A3
gene id: 9646:SRD5A3
uniprot id: D2HBV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).

9646:EMG1
gene id: 9646:EMG1
uniprot id: D2HIZ9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9646:LOC100481888
gene id: 9646:LOC100481888
uniprot id: G1L036
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

9646:TGM5
gene id: 9646:TGM5
uniprot id: G1MAR9
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9646:LOC100481887
gene id: 9646:LOC100481887
uniprot id: G1M666
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9646:LOC100463546
gene id: 9646:LOC100463546
uniprot id: D2H2E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space
messages: Required for assembly of mitochondrial respiratory chain complexes.

9646:IKBKB
gene id: 9646:IKBKB
uniprot id: A0A7N5JDS8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:MRPL51
gene id: 9646:MRPL51
uniprot id: D2HJ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Mitochondrion

9646:HBEGF
gene id: 9646:HBEGF
uniprot id: A0A7N5KEF7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:NPSR1
gene id: 9646:NPSR1
uniprot id: G1L4I8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:MTF2
gene id: 9646:MTF2
uniprot id: G1LTG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9646:LOC100468905
gene id: 9646:LOC100468905
uniprot id: G1L767
names: Similarity
messages: Belongs to the TMEM14 family.

9646:CPXM1
gene id: 9646:CPXM1
uniprot id: G1LXJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9646:PTCD3
gene id: 9646:PTCD3
uniprot id: G1LH43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9646:RPS25
gene id: 9646:RPS25
uniprot id: C6ZIA4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the small ribosomal subunit.

9646:ING1
gene id: 9646:ING1
uniprot id: G1MF89
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9646:ADGRL4
gene id: 9646:ADGRL4
uniprot id: G1MIU4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:UNC5C
gene id: 9646:UNC5C
uniprot id: A0A7N5JIU3
uniprot id: G1LHL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9646:SIGMAR1
gene id: 9646:SIGMAR1
uniprot id: D2I5R7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle
messages: growth cone

9646:LOC100473307
gene id: 9646:LOC100473307
uniprot id: G1L479
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:CRYBA2
gene id: 9646:CRYBA2
uniprot id: D2GXC2
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9646:LIPG
gene id: 9646:LIPG
uniprot id: A0A7N5K5N8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9646:DLG5
gene id: 9646:DLG5
uniprot id: D2H986
names: Subcellular Location Annotation
messages: Cytoplasm

9646:PI4KB
gene id: 9646:PI4KB
uniprot id: A0A7N5JM62
uniprot id: A0A7N5KC82
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9646:CPNE3
gene id: 9646:CPNE3
uniprot id: D2H5C8
names: Similarity
messages: Belongs to the copine family.

9646:VWA2
gene id: 9646:VWA2
uniprot id: A0A7N5K398
uniprot id: A0A7N5KPH3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:LOC100466888
gene id: 9646:LOC100466888
uniprot id: A0A7N5JDC4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9646:CIRBP
gene id: 9646:CIRBP
uniprot id: A0A7N5KLY9
uniprot id: G1L986
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with EIF4G1. Associates with ribosomes.
messages: nucleoplasm

9646:LOC100467551
gene id: 9646:LOC100467551
uniprot id: G1LQL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9646:MFAP2
gene id: 9646:MFAP2
uniprot id: G1L0V0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9646:DGLUCY
gene id: 9646:DGLUCY
uniprot id: G1L4I2
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

9646:SEC31A
gene id: 9646:SEC31A
uniprot id: A0A7N5KFD7
uniprot id: A0A7N5KS88
uniprot id: D2GUF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

9646:ALB
gene id: 9646:ALB
uniprot id: G1LEJ5
names: Subcellular Location Annotation
messages: Secreted

9646:CAV3
gene id: 9646:CAV3
uniprot id: A0A7N5P346
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9646:LOC100484526
gene id: 9646:LOC100484526
uniprot id: G1M8S8
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

9646:PROKR1
gene id: 9646:PROKR1
uniprot id: D2I171
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:TPM2
gene id: 9646:TPM2
uniprot id: G1LSK6
uniprot id: G1LTE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9646:AIG1
gene id: 9646:AIG1
uniprot id: A0A7N5KFN7
uniprot id: A0A7N5KNI4
uniprot id: A0A7N5KR13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9646:CA5A
gene id: 9646:CA5A
uniprot id: A0A7N5P7R4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9646:BLVRA
gene id: 9646:BLVRA
uniprot id: A0A7N5JA78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
messages: Monomer.
messages: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
messages: cytosol

9646:MDH1B
gene id: 9646:MDH1B
uniprot id: G1L873
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9646:LOC100475287
gene id: 9646:LOC100475287
uniprot id: G1MKL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:HPS6
gene id: 9646:HPS6
uniprot id: G1MPH5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

9646:FGF12
gene id: 9646:FGF12
uniprot id: G1LQH1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9646:CSRNP2
gene id: 9646:CSRNP2
uniprot id: D2HHE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9646:SRP54
gene id: 9646:SRP54
uniprot id: G1MAQ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

9646:SMG9
gene id: 9646:SMG9
uniprot id: G1LC28
names: Similarity
messages: Belongs to the SMG9 family.

9646:LOC100477257
gene id: 9646:LOC100477257
uniprot id: D2I0K6
names: Similarity
messages: Belongs to the peptidase A1 family.

9646:MFNG
gene id: 9646:MFNG
uniprot id: G1LTS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:LOC100481285
gene id: 9646:LOC100481285
uniprot id: D2HZU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:CLCN3
gene id: 9646:CLCN3
uniprot id: A0A7N5K803
uniprot id: D2H8P8
uniprot id: G1M3S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9646:CACNA2D1
gene id: 9646:CACNA2D1
uniprot id: A0A7N5K985
uniprot id: G1ME42
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9646:RAD9A
gene id: 9646:RAD9A
uniprot id: D2HGP8
names: Similarity
messages: Belongs to the rad9 family.

9646:STAG2
gene id: 9646:STAG2
uniprot id: G1MBD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9646:RPE
gene id: 9646:RPE
uniprot id: D2HJA5
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

9646:TIMM8B
gene id: 9646:TIMM8B
uniprot id: D2HG80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9646:HOXA2
gene id: 9646:HOXA2
uniprot id: D2GVC1
names: Subcellular Location Annotation
messages: Nucleus

9646:CETN2
gene id: 9646:CETN2
uniprot id: G1L0I0
names: Similarity
messages: Belongs to the centrin family.

9646:CCL5
gene id: 9646:CCL5
uniprot id: A0A7N5JVR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9646:ING4
gene id: 9646:ING4
uniprot id: G1M6E8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9646:C1S
gene id: 9646:C1S
uniprot id: G1M541
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:SLC25A37
gene id: 9646:SLC25A37
uniprot id: D2H029
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9646:POU3F4
gene id: 9646:POU3F4
uniprot id: D2I4C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9646:IPMK
gene id: 9646:IPMK
uniprot id: D2I215
uniprot id: G1LUP1
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9646:GNRH1
gene id: 9646:GNRH1
uniprot id: G1L0K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

9646:WNT2B
gene id: 9646:WNT2B
uniprot id: G1LA82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9646:FXR1
gene id: 9646:FXR1
uniprot id: A0A7N5KIC5
uniprot id: A0A7N5KL63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cytoplasmic ribonucleoprotein granule
messages: Nucleus envelope
messages: Postsynapse
messages: Synapse
messages: dendritic spine

9646:PCNX4
gene id: 9646:PCNX4
uniprot id: G1L837
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9646:ZFX
gene id: 9646:ZFX
uniprot id: G1M1Z9
names: Subcellular Location Annotation
messages: Nucleus

9646:GIPR
gene id: 9646:GIPR
uniprot id: D2I071
names: Subcellular Location Annotation
messages: Membrane

9646:DNAAF4
gene id: 9646:DNAAF4
uniprot id: D2HKV7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Dynein axonemal particle
messages: neuron projection

9646:PPARGC1B
gene id: 9646:PPARGC1B
uniprot id: D2H8M8
names: Subcellular Location Annotation
messages: Nucleus

9646:POLR3H
gene id: 9646:POLR3H
uniprot id: A0A7N5P9Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9646:LOC100483137
gene id: 9646:LOC100483137
uniprot id: D2HZN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:IL5
gene id: 9646:IL5
uniprot id: G1MH72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked. Interacts with IL5RA. Interacts with CSF2RB.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

9646:PSMD7
gene id: 9646:PSMD7
uniprot id: A0A7N5JNG0
names: Similarity
messages: Belongs to the peptidase M67A family.

9646:UTP23
gene id: 9646:UTP23
uniprot id: G1LUU0
names: Subcellular Location Annotation
messages: nucleolus

9646:LRRC8B
gene id: 9646:LRRC8B
uniprot id: D2HJK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9646:PARK7
gene id: 9646:PARK7
uniprot id: D2HA21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9646:SLC43A1
gene id: 9646:SLC43A1
uniprot id: G1M7G7
names: Subcellular Location Annotation
messages: Membrane

9646:MPDZ
gene id: 9646:MPDZ
uniprot id: A0A7N5K9B7
uniprot id: G1L4U6
names: Subcellular Location Annotation
messages: Cell membrane
messages: tight junction

9646:MRPL41
gene id: 9646:MRPL41
uniprot id: D2HU66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

9646:AADACL3
gene id: 9646:AADACL3
uniprot id: A0A7N5JQB1
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9646:PARD6B
gene id: 9646:PARD6B
uniprot id: A0A7N5JNY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9646:GLB1L
gene id: 9646:GLB1L
uniprot id: D2GXB2
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9646:OLR1
gene id: 9646:OLR1
uniprot id: A0A7N5KET8
names: Subcellular Location Annotation
messages: Membrane

9646:CLDN10
gene id: 9646:CLDN10
uniprot id: D2H9Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9646:TSPAN31
gene id: 9646:TSPAN31
uniprot id: G1LFF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9646:HDAC1
gene id: 9646:HDAC1
uniprot id: G1LM86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
messages: Nucleus

9646:PEX19
gene id: 9646:PEX19
uniprot id: A0A7N5JF82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9646:NIF3L1
gene id: 9646:NIF3L1
uniprot id: D2H2Q0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

9646:CCKBR
gene id: 9646:CCKBR
uniprot id: D2HR68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9646:SERPINB1
gene id: 9646:SERPINB1
uniprot id: D2I4F1
names: Similarity
messages: Belongs to the serpin family.

9646:EIF3M
gene id: 9646:EIF3M
uniprot id: G1LKE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9646:AK5
gene id: 9646:AK5
uniprot id: G1LKZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

9646:UBE3A
gene id: 9646:UBE3A
uniprot id: G1LKJ5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

9646:KCNT2
gene id: 9646:KCNT2
uniprot id: D2HWF1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:GOLM2
gene id: 9646:GOLM2
uniprot id: A0A7N5JQR1
uniprot id: G1M9E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9646:AOX2
gene id: 9646:AOX2
uniprot id: G1LGX7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9646:SGO1
gene id: 9646:SGO1
uniprot id: G1L248
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9646:GTPBP3
gene id: 9646:GTPBP3
uniprot id: G1LVE0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

9646:KATNA1
gene id: 9646:KATNA1
uniprot id: D2HEQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: spindle

9646:LOC100464393
gene id: 9646:LOC100464393
uniprot id: G1L563
names: Similarity
messages: Belongs to the MHC class II family.

9646:CNMD
gene id: 9646:CNMD
uniprot id: G1LPS0
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9646:GATA1
gene id: 9646:GATA1
uniprot id: D2H7N5
names: Subcellular Location Annotation
messages: Nucleus

9646:HIGD2A
gene id: 9646:HIGD2A
uniprot id: G1LKA4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9646:HBS1L
gene id: 9646:HBS1L
uniprot id: A0A7N5KM59
uniprot id: G1LTA8
names: Subcellular Location Annotation
messages: Cytoplasm

9646:COG3
gene id: 9646:COG3
uniprot id: G1M381
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9646:PPCS
gene id: 9646:PPCS
uniprot id: G1L126
names: Similarity
messages: Belongs to the PPC synthetase family.

9646:PPP3CA
gene id: 9646:PPP3CA
uniprot id: A0A7N5JYZ7
uniprot id: G1LQC9
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9646:CLIP1
gene id: 9646:CLIP1
uniprot id: G1M838
names: Subcellular Location Annotation
messages: cytoskeleton

9646:POLR3GL
gene id: 9646:POLR3GL
uniprot id: D2HQ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

9646:MAN1A2
gene id: 9646:MAN1A2
uniprot id: D2HQ28
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9646:TRMT112
gene id: 9646:TRMT112
uniprot id: D2H4T4
names: Similarity
messages: Belongs to the TRM112 family.

9646:TSNAX
gene id: 9646:TSNAX
uniprot id: G1L7A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9646:IGF1
gene id: 9646:IGF1
uniprot id: A0A7N5JMM9
uniprot id: G1LIG6
uniprot id: Q6JLX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).

9646:NDST3
gene id: 9646:NDST3
uniprot id: D2H9J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9646:YPEL4
gene id: 9646:YPEL4
uniprot id: D2HK66
names: Similarity
messages: Belongs to the yippee family.

9646:CHURC1
gene id: 9646:CHURC1
uniprot id: A0A7N5JKR9
names: Similarity
messages: Belongs to the Churchill family.

9646:SDAD1
gene id: 9646:SDAD1
uniprot id: G1LZ27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9646:LCLAT1
gene id: 9646:LCLAT1
uniprot id: A0A7N5K9A9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9646:CRISP2
gene id: 9646:CRISP2
uniprot id: G1LQC8
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:GDF10
gene id: 9646:GDF10
uniprot id: D2I4F6
names: Similarity
messages: Belongs to the TGF-beta family.

9646:TMEM183A
gene id: 9646:TMEM183A
uniprot id: D2HSE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

9646:LOC100478125
gene id: 9646:LOC100478125
uniprot id: D2I6P0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:TACC1
gene id: 9646:TACC1
uniprot id: G1MAG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9646:CACNB4
gene id: 9646:CACNB4
uniprot id: G1LQD3
uniprot id: G1LQE1
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9646:B4GAT1
gene id: 9646:B4GAT1
uniprot id: D2H4M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9646:SEC23A
gene id: 9646:SEC23A
uniprot id: D2H485
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9646:TM2D3
gene id: 9646:TM2D3
uniprot id: A0A7N5JTI6
uniprot id: G1L8K8
names: Subcellular Location Annotation
messages: Membrane

9646:AOX4
gene id: 9646:AOX4
uniprot id: M1ZMK9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9646:RRP8
gene id: 9646:RRP8
uniprot id: G1MCZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Component of the eNoSC complex.
messages: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.
messages: nucleolus

9646:TPH2
gene id: 9646:TPH2
uniprot id: G1L0L6
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9646:AFF1
gene id: 9646:AFF1
uniprot id: G1L9J1
uniprot id: G1L9K4
names: Similarity
messages: Belongs to the AF4 family.

9646:NDUFB9
gene id: 9646:NDUFB9
uniprot id: D2I1Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9646:LOC100476785
gene id: 9646:LOC100476785
uniprot id: D2GXX0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9646:GATB
gene id: 9646:GATB
uniprot id: G1MJF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9646:KEG54 p12
gene id: 9646:KEG54_p12
uniprot id: Q534B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9646:NDFIP2
gene id: 9646:NDFIP2
uniprot id: D2HDE3
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9646:IMMT
gene id: 9646:IMMT
uniprot id: G1LHA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9646:PDCL3
gene id: 9646:PDCL3
uniprot id: G1MAY7
names: Similarity
messages: Belongs to the phosducin family.

9646:PSMC5
gene id: 9646:PSMC5
uniprot id: G1L8T5
names: Similarity
messages: Belongs to the AAA ATPase family.

9646:RAB29
gene id: 9646:RAB29
uniprot id: A0A7N5KGW3
uniprot id: D2I003
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9646:CUL1
gene id: 9646:CUL1
uniprot id: D2HN20
names: Similarity
messages: Belongs to the cullin family.

9646:LOC100481522
gene id: 9646:LOC100481522
uniprot id: G1M0M8
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9646:NMNAT2
gene id: 9646:NMNAT2
uniprot id: G1L6E7
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9646:TAF15
gene id: 9646:TAF15
uniprot id: G1M8L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9646:KIF9
gene id: 9646:KIF9
uniprot id: G1M2D9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9646:DPH6
gene id: 9646:DPH6
uniprot id: G1LF73
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
messages: Belongs to the Diphthine--ammonia ligase family.

9646:IL1F10
gene id: 9646:IL1F10
uniprot id: A0A7N5JG56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

9646:SNUPN
gene id: 9646:SNUPN
uniprot id: D2HRJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

9646:RFC4
gene id: 9646:RFC4
uniprot id: D2H072
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9646:LOC100474871
gene id: 9646:LOC100474871
uniprot id: G1M1M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Functions as transport protein in the blood stream.
messages: Secreted

9646:PAXBP1
gene id: 9646:PAXBP1
uniprot id: D2HCG8
names: Similarity
messages: Belongs to the GCF family.

9646:SLC6A13
gene id: 9646:SLC6A13
uniprot id: A0A7N5JQB8
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9646:GNG8
gene id: 9646:GNG8
uniprot id: D2HL52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9646:ZSCAN25
gene id: 9646:ZSCAN25
uniprot id: D2HP64
names: Subcellular Location Annotation
messages: Nucleus

9646:KIF1B
gene id: 9646:KIF1B
uniprot id: A0A7N5JU37
uniprot id: G1LJJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

9646:INSL6
gene id: 9646:INSL6
uniprot id: D2HMS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9646:GPRC5D
gene id: 9646:GPRC5D
uniprot id: G1LW29
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9646:DKK3
gene id: 9646:DKK3
uniprot id: D2HS07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9646:TSPAN32
gene id: 9646:TSPAN32
uniprot id: G1L602
names: Subcellular Location Annotation
messages: Membrane

9646:PDHB
gene id: 9646:PDHB
uniprot id: A0A7N5JY85
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9646:ADNP
gene id: 9646:ADNP
uniprot id: D2GVM8
names: Subcellular Location Annotation
messages: Nucleus

9646:TRADD
gene id: 9646:TRADD
uniprot id: G1MFS1
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

9646:SYNGR4
gene id: 9646:SYNGR4
uniprot id: D2H801
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9646:GJB3
gene id: 9646:GJB3
uniprot id: D2H619
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9646:RETREG3
gene id: 9646:RETREG3
uniprot id: D2HIU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:SEC22C
gene id: 9646:SEC22C
uniprot id: D2HSV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9646:FLNB
gene id: 9646:FLNB
uniprot id: A0A7N5K6W9
uniprot id: D2GX06
names: Similarity
messages: Belongs to the filamin family.

9646:LOC100473693
gene id: 9646:LOC100473693
uniprot id: F2X216
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9646:SKP1
gene id: 9646:SKP1
uniprot id: G1MHH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.
messages: The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.

9646:RFTN2
gene id: 9646:RFTN2
uniprot id: D2HDI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9646:KCNK18
gene id: 9646:KCNK18
uniprot id: G1M677
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9646:CHRM5
gene id: 9646:CHRM5
uniprot id: D2HRS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9646:KCNJ5
gene id: 9646:KCNJ5
uniprot id: D2GUX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

9646:SCNN1G
gene id: 9646:SCNN1G
uniprot id: G1LXW8
names: Subcellular Location Annotation
messages: Membrane

9646:ARL5C
gene id: 9646:ARL5C
uniprot id: G1LC18
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9646:SYNE4
gene id: 9646:SYNE4
uniprot id: G1L217
names: Similarity
messages: Belongs to the nesprin family.

9646:BMP3
gene id: 9646:BMP3
uniprot id: D2GUF8
names: Similarity
messages: Belongs to the TGF-beta family.

9646:NSG2
gene id: 9646:NSG2
uniprot id: D2H5G0
names: Similarity
messages: Belongs to the NSG family.

9646:CERS1
gene id: 9646:CERS1
uniprot id: G1LYF3
names: Subcellular Location Annotation
messages: Membrane

9646:CD9
gene id: 9646:CD9
uniprot id: B1NH59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

9646:ACAA1
gene id: 9646:ACAA1
uniprot id: D2GZQ8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9646:LOC100471797
gene id: 9646:LOC100471797
uniprot id: G1MJP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:KLHL3
gene id: 9646:KLHL3
uniprot id: A0A7N5JFM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KLHL3 family.
messages: cytoskeleton
messages: cytosol

9646:CDH3
gene id: 9646:CDH3
uniprot id: G1LMM1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9646:FITM2
gene id: 9646:FITM2
uniprot id: D2H6K9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9646:ASPH
gene id: 9646:ASPH
uniprot id: A0A7N5P4I8
names: Subcellular Location Annotation
messages: Membrane

9646:CTSC
gene id: 9646:CTSC
uniprot id: D2HR89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9646:RFC5
gene id: 9646:RFC5
uniprot id: G1MCL9
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9646:SSTR3
gene id: 9646:SSTR3
uniprot id: G1MNJ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:PIP4P2
gene id: 9646:PIP4P2
uniprot id: D2H4L0
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9646:WWP1
gene id: 9646:WWP1
uniprot id: G1L7C7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:LOC105236555
gene id: 9646:LOC105236555
uniprot id: A0A7N5P9Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9646:LOC100476991
gene id: 9646:LOC100476991
uniprot id: G1MPF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:RAB3D
gene id: 9646:RAB3D
uniprot id: D2HGW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9646:KMT5C
gene id: 9646:KMT5C
uniprot id: A0A7N5JJS1
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100480617
gene id: 9646:LOC100480617
uniprot id: G1MMX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:AMBN
gene id: 9646:AMBN
uniprot id: G1LGX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

9646:SLC26A10
gene id: 9646:SLC26A10
uniprot id: G1LF25
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:CNOT1
gene id: 9646:CNOT1
uniprot id: D2GTZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

9646:EFNA5
gene id: 9646:EFNA5
uniprot id: A0A7N5K3Y1
uniprot id: G1L3C8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9646:UTP15
gene id: 9646:UTP15
uniprot id: D2I2V4
names: Subcellular Location Annotation
messages: nucleolus

9646:CPS1
gene id: 9646:CPS1
uniprot id: D2HJB0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:SNRPN
gene id: 9646:SNRPN
uniprot id: G1LKF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9646:KCNN3
gene id: 9646:KCNN3
uniprot id: D2HJN4
names: Subcellular Location Annotation
messages: Membrane

9646:CKAP2
gene id: 9646:CKAP2
uniprot id: A0A7N5KI27
names: Similarity
messages: Belongs to the CKAP2 family.

9646:CETN1
gene id: 9646:CETN1
uniprot id: D2HJY5
names: Similarity
messages: Belongs to the centrin family.

9646:MMP12
gene id: 9646:MMP12
uniprot id: G1LMV7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9646:CDPF1
gene id: 9646:CDPF1
uniprot id: A0A7N5JX93
names: Similarity
messages: Belongs to the CDPF1 family.

9646:TIMM23
gene id: 9646:TIMM23
uniprot id: G1LLS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9646:PHF20
gene id: 9646:PHF20
uniprot id: D2H459
names: Subcellular Location Annotation
messages: Nucleus

9646:GPR161
gene id: 9646:GPR161
uniprot id: A0A7N5KFK4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:PYM1
gene id: 9646:PYM1
uniprot id: A0A7N5P720
names: Similarity
names: Subunit
messages: Belongs to the pym family.
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

9646:CCHCR1
gene id: 9646:CCHCR1
uniprot id: G1LV50
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

9646:WFIKKN1
gene id: 9646:WFIKKN1
uniprot id: G1LKW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WFIKKN family.
messages: Secreted

9646:OTOP3
gene id: 9646:OTOP3
uniprot id: G1LR34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9646:PLSCR1
gene id: 9646:PLSCR1
uniprot id: A0A7N5K6X5
uniprot id: A0A7N5KEI0
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9646:ARL6IP5
gene id: 9646:ARL6IP5
uniprot id: D2HPQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9646:CILP
gene id: 9646:CILP
uniprot id: G1L7Y1
names: Subcellular Location Annotation
messages: extracellular matrix

9646:FAM227A
gene id: 9646:FAM227A
uniprot id: G1LVL5
names: Similarity
messages: Belongs to the FAM227 family.

9646:MARS1
gene id: 9646:MARS1
uniprot id: G1LEG6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9646:UBA52
gene id: 9646:UBA52
uniprot id: D2GV37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).

9646:CHFR
gene id: 9646:CHFR
uniprot id: G1M455
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHFR family.
messages: PML body

9646:CPNE6
gene id: 9646:CPNE6
uniprot id: D2HG62
names: Similarity
messages: Belongs to the copine family.

9646:RHO
gene id: 9646:RHO
uniprot id: D2HGN0
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore.
messages: Membrane

9646:COPS5
gene id: 9646:COPS5
uniprot id: D2H427
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9646:FMO2
gene id: 9646:FMO2
uniprot id: G1MF96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9646:POLR2B
gene id: 9646:POLR2B
uniprot id: A0A7N5K734
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9646:ASPN
gene id: 9646:ASPN
uniprot id: A0A7N5KJU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9646:A1CF
gene id: 9646:A1CF
uniprot id: D2GZ28
names: Subcellular Location Annotation
messages: Cytoplasm

9646:RUVBL1
gene id: 9646:RUVBL1
uniprot id: D2H7C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9646:NPM3
gene id: 9646:NPM3
uniprot id: D2GXV0
names: Similarity
messages: Belongs to the nucleoplasmin family.

9646:MRPS14
gene id: 9646:MRPS14
uniprot id: A0A7N5JJI4
uniprot id: D2HYZ4
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

9646:RAB38
gene id: 9646:RAB38
uniprot id: D2HR88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9646:ZC3H15
gene id: 9646:ZC3H15
uniprot id: G1LNZ1
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

9646:LOC100476469
gene id: 9646:LOC100476469
uniprot id: D2HE84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9646:EAF2
gene id: 9646:EAF2
uniprot id: G1M6I0
names: Similarity
messages: Belongs to the EAF family.

9646:AGPAT3
gene id: 9646:AGPAT3
uniprot id: D2HTK6
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9646:PPP1CA
gene id: 9646:PPP1CA
uniprot id: G1L1P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9646:SH3RF2
gene id: 9646:SH3RF2
uniprot id: D2HQF4
uniprot id: G1MGT4
names: Similarity
messages: Belongs to the SH3RF family.

9646:PPP1R1B
gene id: 9646:PPP1R1B
uniprot id: A0A7N5KR97
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9646:RNF167
gene id: 9646:RNF167
uniprot id: G1LIJ0
names: Subcellular Location Annotation
messages: Membrane

9646:ACOX3
gene id: 9646:ACOX3
uniprot id: D2H4I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9646:RIC8B
gene id: 9646:RIC8B
uniprot id: A0A7N5J9Q3
uniprot id: D2HXV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9646:KBTBD8
gene id: 9646:KBTBD8
uniprot id: G1LBI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

9646:SIVA1
gene id: 9646:SIVA1
uniprot id: A0A7N5K186
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus

9646:TJAP1
gene id: 9646:TJAP1
uniprot id: A0A7N5KQY6
uniprot id: D2GZB7
names: Subcellular Location Annotation
messages: Membrane

9646:PKN2
gene id: 9646:PKN2
uniprot id: G1MCL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9646:ACTL6B
gene id: 9646:ACTL6B
uniprot id: D2HX07
names: Similarity
messages: Belongs to the actin family.

9646:CRISPLD2
gene id: 9646:CRISPLD2
uniprot id: G1MJ04
names: Similarity
messages: Belongs to the CRISP family.

9646:LOC100472368
gene id: 9646:LOC100472368
uniprot id: D2HIU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9646:PKP1
gene id: 9646:PKP1
uniprot id: A0A7N5J9M5
names: Similarity
messages: Belongs to the beta-catenin family.

9646:NMD3
gene id: 9646:NMD3
uniprot id: A0A7N5KJX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

9646:BNIP1
gene id: 9646:BNIP1
uniprot id: A0A7N5P6S7
uniprot id: G1LXU0
names: Subcellular Location Annotation
messages: Membrane

9646:DGAT2L6
gene id: 9646:DGAT2L6
uniprot id: G1LR57
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:BNIP3L
gene id: 9646:BNIP3L
uniprot id: G1MD48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9646:PPP6R1
gene id: 9646:PPP6R1
uniprot id: D2HUV3
names: Similarity
messages: Belongs to the SAPS family.

9646:SNCA
gene id: 9646:SNCA
uniprot id: A0A7N5JWV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse
messages: axon

9646:BEND6
gene id: 9646:BEND6
uniprot id: D2HAN6
names: Subcellular Location Annotation
messages: Nucleus

9646:MRPS16
gene id: 9646:MRPS16
uniprot id: G1MEV2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9646:CYGB
gene id: 9646:CYGB
uniprot id: G1LUZ9
names: Similarity
messages: Belongs to the globin family.

9646:STK11IP
gene id: 9646:STK11IP
uniprot id: G1MES4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STK11IP family.
messages: Cytoplasm

9646:LOC100478578
gene id: 9646:LOC100478578
uniprot id: G1LBC7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane
messages: sarcolemma

9646:PPY
gene id: 9646:PPY
uniprot id: D2HCU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9646:GPM6B
gene id: 9646:GPM6B
uniprot id: A0A7N5JGB6
uniprot id: A0A7N5KDE0
uniprot id: G1MBU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9646:SGCG
gene id: 9646:SGCG
uniprot id: A0A7N5P8I0
uniprot id: D2HF48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9646:ZRANB2
gene id: 9646:ZRANB2
uniprot id: A0A7N5KFW2
uniprot id: G1LAZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9646:YAE1
gene id: 9646:YAE1
uniprot id: D2GYH2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9646:ASRGL1
gene id: 9646:ASRGL1
uniprot id: D2HS94
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

9646:FYTTD1
gene id: 9646:FYTTD1
uniprot id: G1LBP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle
messages: nucleoplasm

9646:LOC100468875
gene id: 9646:LOC100468875
uniprot id: D2HYC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9646:LOC100478335
gene id: 9646:LOC100478335
uniprot id: A0A7N5K9C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:LOC100476918
gene id: 9646:LOC100476918
uniprot id: D2HD52
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:DDIT3
gene id: 9646:DDIT3
uniprot id: D2H385
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9646:CENPK
gene id: 9646:CENPK
uniprot id: G1LXA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

9646:HPX
gene id: 9646:HPX
uniprot id: G1MD79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Secreted

9646:PIWIL2
gene id: 9646:PIWIL2
uniprot id: D2H044
uniprot id: G1L913
names: Similarity
messages: Belongs to the argonaute family.

9646:RBBP5
gene id: 9646:RBBP5
uniprot id: A0A7N5JGT4
names: Subcellular Location Annotation
messages: Nucleus

9646:LOC100464006
gene id: 9646:LOC100464006
uniprot id: A0A7N5K2E6
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9646:ARV1
gene id: 9646:ARV1
uniprot id: G1L6W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9646:PSD
gene id: 9646:PSD
uniprot id: G1MHE4
names: Subcellular Location Annotation
messages: Membrane
messages: ruffle membrane

9646:CAPN6
gene id: 9646:CAPN6
uniprot id: D2HEA2
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:LOC100480024
gene id: 9646:LOC100480024
uniprot id: D2HWJ2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9646:SMIM8
gene id: 9646:SMIM8
uniprot id: A0A7N5KH18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9646:SBNO1
gene id: 9646:SBNO1
uniprot id: A0A7N5JI57
names: Similarity
messages: Belongs to the SBNO family.

9646:LOC100469088
gene id: 9646:LOC100469088
uniprot id: G1L7K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9646:GABRP
gene id: 9646:GABRP
uniprot id: D2HKP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:APOC4
gene id: 9646:APOC4
uniprot id: G1M237
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C4 family.
messages: May participate in lipoprotein metabolism.
messages: Secreted

9646:LOC100474740
gene id: 9646:LOC100474740
uniprot id: G1MJX5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:WNT16
gene id: 9646:WNT16
uniprot id: D2HJH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9646:ZNF483
gene id: 9646:ZNF483
uniprot id: G1MHZ5
names: Subcellular Location Annotation
messages: Nucleus

9646:RPA3
gene id: 9646:RPA3
uniprot id: D2HD14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9646:LOC100468201
gene id: 9646:LOC100468201
uniprot id: D2I0V9
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9646:NR1H2
gene id: 9646:NR1H2
uniprot id: D2H7T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9646:NOL10
gene id: 9646:NOL10
uniprot id: G1LYD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

9646:MFSD11
gene id: 9646:MFSD11
uniprot id: D2H993
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9646:SLC7A7
gene id: 9646:SLC7A7
uniprot id: D2HTV4
names: Subcellular Location Annotation
messages: Membrane

9646:SMARCAL1
gene id: 9646:SMARCAL1
uniprot id: G1L9L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

9646:NOP16
gene id: 9646:NOP16
uniprot id: G1LKA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9646:NOC2L
gene id: 9646:NOC2L
uniprot id: G1MDP3
names: Similarity
messages: Belongs to the NOC2 family.

9646:ART4
gene id: 9646:ART4
uniprot id: G1LSN6
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9646:DHRS7C
gene id: 9646:DHRS7C
uniprot id: G1M086
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9646:RPL12
gene id: 9646:RPL12
uniprot id: F2X246
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9646:CSF2
gene id: 9646:CSF2
uniprot id: A0A7N5KI24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9646:TM2D2
gene id: 9646:TM2D2
uniprot id: D2HRV9
names: Subcellular Location Annotation
messages: Membrane

9646:FOXN2
gene id: 9646:FOXN2
uniprot id: D2GUB8
names: Subcellular Location Annotation
messages: Nucleus

9646:MTHFR
gene id: 9646:MTHFR
uniprot id: G1LTB1
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

9646:STC2
gene id: 9646:STC2
uniprot id: D2H5F6
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9646:CRHR2
gene id: 9646:CRHR2
uniprot id: A0A7N5JY89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

9646:NUBPL
gene id: 9646:NUBPL
uniprot id: G1MB55
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

9646:FCGR1A
gene id: 9646:FCGR1A
uniprot id: G1LKK5
names: Subcellular Location Annotation
messages: Cell membrane

9646:PFDN4
gene id: 9646:PFDN4
uniprot id: G1M3F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9646:WASHC3
gene id: 9646:WASHC3
uniprot id: A0A7N5JHI2
names: Similarity
messages: Belongs to the CCDC53 family.

9646:SLC46A1
gene id: 9646:SLC46A1
uniprot id: G1LEG4
names: Subcellular Location Annotation
messages: Membrane

9646:TBPL1
gene id: 9646:TBPL1
uniprot id: D2HJ41
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9646:LOC100465553
gene id: 9646:LOC100465553
uniprot id: D2I817
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:FAM234A
gene id: 9646:FAM234A
uniprot id: D2HDV6
names: Similarity
messages: Belongs to the FAM234 family.

9646:LOC100478886
gene id: 9646:LOC100478886
uniprot id: G1MKY7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:SFRP1
gene id: 9646:SFRP1
uniprot id: D2H9Q0
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9646:SLC29A3
gene id: 9646:SLC29A3
uniprot id: G1MHA5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9646:LOC100478321
gene id: 9646:LOC100478321
uniprot id: D2H9P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9646:LMBR1L
gene id: 9646:LMBR1L
uniprot id: G1LJZ5
names: Similarity
messages: Belongs to the LIMR family.

9646:VTI1B
gene id: 9646:VTI1B
uniprot id: D2HRG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9646:PRKD3
gene id: 9646:PRKD3
uniprot id: D2H089
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Membrane

9646:LOC100467789
gene id: 9646:LOC100467789
uniprot id: A0A7N5KF74
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9646:ATP6V1A
gene id: 9646:ATP6V1A
uniprot id: A0A7N5JXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Vesicle
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

9646:NLN
gene id: 9646:NLN
uniprot id: A0A7N5K055
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9646:LRRC8A
gene id: 9646:LRRC8A
uniprot id: D2H153
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9646:PDF
gene id: 9646:PDF
uniprot id: D2HLI5
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

9646:ATG9A
gene id: 9646:ATG9A
uniprot id: A0A7N5KPY8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9646:HSPA13
gene id: 9646:HSPA13
uniprot id: G1M762
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

9646:GSPT2
gene id: 9646:GSPT2
uniprot id: D2I687
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9646:LOC100467558
gene id: 9646:LOC100467558
uniprot id: A0A7N5P1J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9646:LAMP3
gene id: 9646:LAMP3
uniprot id: A0A7N5JGL8
uniprot id: G1MC11
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9646:KAT5
gene id: 9646:KAT5
uniprot id: A0A7N5K8I8
uniprot id: D2H4P7
uniprot id: G1MG58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9646:OOEP
gene id: 9646:OOEP
uniprot id: G1LMP1
names: Similarity
messages: Belongs to the KHDC1 family.

9646:TPM1
gene id: 9646:TPM1
uniprot id: A0A7N5P393
uniprot id: G1LL03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9646:HTR1B
gene id: 9646:HTR1B
uniprot id: G1MMS2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

9646:LOC100466794
gene id: 9646:LOC100466794
uniprot id: D2GWW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

9646:ZKSCAN1
gene id: 9646:ZKSCAN1
uniprot id: D2I5F1
names: Subcellular Location Annotation
messages: Nucleus

9646:AGTRAP
gene id: 9646:AGTRAP
uniprot id: A0A7N5JQ24
names: Subcellular Location Annotation
messages: Membrane

9646:DAND5
gene id: 9646:DAND5
uniprot id: D2HG20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9646:CHRNA2
gene id: 9646:CHRNA2
uniprot id: G1KZY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9646:STK11
gene id: 9646:STK11
uniprot id: A0A7N5KJH6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.

9646:COMTD1
gene id: 9646:COMTD1
uniprot id: D2HIC8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9646:CNOT9
gene id: 9646:CNOT9
uniprot id: A0A7N5J8T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9646:SMIM18
gene id: 9646:SMIM18
uniprot id: A0A7N5P5Z8
names: Subcellular Location Annotation
messages: Membrane

9646:FIBIN
gene id: 9646:FIBIN
uniprot id: D2HUT9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9646:LOC100475569
gene id: 9646:LOC100475569
uniprot id: D2HK82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:GHRL
gene id: 9646:GHRL
uniprot id: B0ZE69
uniprot id: G1MC20
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
messages: O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
messages: Secreted

9646:SLC6A19
gene id: 9646:SLC6A19
uniprot id: G1LV25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9646:PRF1
gene id: 9646:PRF1
uniprot id: D2GXG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9646:EIF1AD
gene id: 9646:EIF1AD
uniprot id: G1MFU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9646:DNAJC27
gene id: 9646:DNAJC27
uniprot id: A0A7N5JMI7
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9646:PTK2B
gene id: 9646:PTK2B
uniprot id: A0A7N5KFQ2
uniprot id: A0A7N5KJS2
uniprot id: D2GZ67
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9646:EDN1
gene id: 9646:EDN1
uniprot id: G1L7K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9646:GIP
gene id: 9646:GIP
uniprot id: G1LEN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

9646:SMPD3
gene id: 9646:SMPD3
uniprot id: D2HLJ6
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9646:LOC100470989
gene id: 9646:LOC100470989
uniprot id: D2I623
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9646:RTRAF
gene id: 9646:RTRAF
uniprot id: G1L5Q6
names: Similarity
messages: Belongs to the RTRAF family.

9646:RPL11
gene id: 9646:RPL11
uniprot id: D7RAF3
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

9646:PLA2G5
gene id: 9646:PLA2G5
uniprot id: G1L8Z8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9646:GDPD2
gene id: 9646:GDPD2
uniprot id: G1LRW0
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9646:GPR171
gene id: 9646:GPR171
uniprot id: D2H3Z6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9646:KCNB2
gene id: 9646:KCNB2
uniprot id: A0A7N5JB91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: dendrite

9646:MTFP1
gene id: 9646:MTFP1
uniprot id: G1LM10
names: Similarity
messages: Belongs to the MTFP1 family.

9646:GRPEL1
gene id: 9646:GRPEL1
uniprot id: A0A7N5JFN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9646:HIBADH
gene id: 9646:HIBADH
uniprot id: G1LGZ3
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

9646:ARPC4
gene id: 9646:ARPC4
uniprot id: A0A7N5JZ90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

9646:CTSA
gene id: 9646:CTSA
uniprot id: D2HZ11
names: Similarity
messages: Belongs to the peptidase S10 family.

9646:UBE4A
gene id: 9646:UBE4A
uniprot id: G1M3C0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

9646:TSPO2
gene id: 9646:TSPO2
uniprot id: D2I3I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9646:FAM162A
gene id: 9646:FAM162A
uniprot id: A0A7N5J8I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9646:MAP7D3
gene id: 9646:MAP7D3
uniprot id: A0A7N5P8P8
names: Similarity
messages: Belongs to the MAP7 family.

9646:RTF2
gene id: 9646:RTF2
uniprot id: G1LKJ9
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9646:KCNJ13
gene id: 9646:KCNJ13
uniprot id: D2H845
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9646:SDE2
gene id: 9646:SDE2
uniprot id: D2HVM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

9646:KDR
gene id: 9646:KDR
uniprot id: A0A7N5JCT5
uniprot id: G1MJC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane