9615:DPH2
gene id: 9615:DPH2
uniprot id: A0A8C0N7X7
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

9615:NR2F2
gene id: 9615:NR2F2
uniprot id: A0A8C0TP54
uniprot id: A0A8I3MKR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:LOC100687029
gene id: 9615:LOC100687029
uniprot id: A0A8C0Q1G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9615:CHRM5
gene id: 9615:CHRM5
uniprot id: A0A8C0P4S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9615:LAMTOR2
gene id: 9615:LAMTOR2
uniprot id: A0A8C0TCX0
uniprot id: A0A8I3NEX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9615:CENPN
gene id: 9615:CENPN
uniprot id: A0A8C0M0L7
uniprot id: A0A8I3PED2
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9615:OPA1
gene id: 9615:OPA1
uniprot id: A0A8C0TFT4
uniprot id: A0A8I3PQW8
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9615:COMT
gene id: 9615:COMT
uniprot id: A0A8P0SIL1
uniprot id: Q69FG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
messages: Cell membrane

9615:SLC2A8
gene id: 9615:SLC2A8
uniprot id: B4YY04
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9615:SULF2
gene id: 9615:SULF2
uniprot id: A0A8C0S0M9
uniprot id: Q32KH1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:FSCN2
gene id: 9615:FSCN2
uniprot id: A0A8C0Q2X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9615:CCNY
gene id: 9615:CCNY
uniprot id: A0A8C0PJW0
uniprot id: A0A8I3MYX8
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9615:XYLT2
gene id: 9615:XYLT2
uniprot id: Q5QQ50
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Active with either Mg(2+) or Mn(2+), but activity is highest when both are present.
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN (By similarity). Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity).
messages: Contains disulfide bonds.
messages: Golgi apparatus membrane
messages: Monomer.
messages: Secreted

9615:TAS2R41
gene id: 9615:TAS2R41
uniprot id: Q2ABC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:LIMS1
gene id: 9615:LIMS1
uniprot id: A0A8C0PAG7
uniprot id: A0A8C0PDK7
uniprot id: A0A8C0SNU6
uniprot id: A0A8C0SQL4
uniprot id: A0A8C0YZ34
uniprot id: A0A8I3MXQ5
uniprot id: A0A8I3N639
uniprot id: A0A8I3N8H0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9615:SIN3B
gene id: 9615:SIN3B
uniprot id: A0A8C0STH5
uniprot id: A0A8I3Q6Z7
names: Subcellular Location Annotation
messages: Nucleus

9615:C4BPA
gene id: 9615:C4BPA
uniprot id: A0A8C0YYV5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:BYSL
gene id: 9615:BYSL
uniprot id: A0A8C0MBF4
uniprot id: A0A8I3NTP7
names: Similarity
messages: Belongs to the bystin family.

9615:TNFAIP3
gene id: 9615:TNFAIP3
uniprot id: A0A8C0PVN6
uniprot id: A0A8I3RUY7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:FIBIN
gene id: 9615:FIBIN
uniprot id: A0A8C0RRE7
uniprot id: A0A8I3PPG3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9615:EIF4A2
gene id: 9615:EIF4A2
uniprot id: A0A8C0P6Q6
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9615:OR2C3
gene id: 9615:OR2C3
uniprot id: A0A8C0M1I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:PGM2L1
gene id: 9615:PGM2L1
uniprot id: A0A8P0N864
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9615:DLX2
gene id: 9615:DLX2
uniprot id: A0A8P0NLZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9615:OSBPL1A
gene id: 9615:OSBPL1A
uniprot id: A0A8C0SU23
uniprot id: A0A8I3NPK5
names: Similarity
messages: Belongs to the OSBP family.

9615:BMP4
gene id: 9615:BMP4
uniprot id: A0A8C0M2B6
uniprot id: A0A8I3MKS3
names: Similarity
messages: Belongs to the TGF-beta family.

9615:GK5
gene id: 9615:GK5
uniprot id: A0A8C0MBX9
uniprot id: A0A8I3Q0Z5
names: Similarity
messages: Belongs to the FGGY kinase family.

9615:ARRDC1
gene id: 9615:ARRDC1
uniprot id: A0A8C0RDZ2
uniprot id: A0A8I3PFH3
names: Similarity
messages: Belongs to the arrestin family.

9615:QTRT2
gene id: 9615:QTRT2
uniprot id: A0A8C0PW06
uniprot id: A0A8I3P465
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9615:MFAP5
gene id: 9615:MFAP5
uniprot id: A0A8C0PGR4
uniprot id: A0A8C0TCJ1
uniprot id: A0A8C0Z3D9
uniprot id: A0A8I3Q3K0
uniprot id: A0A8I3Q404
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

9615:DNAJC27
gene id: 9615:DNAJC27
uniprot id: A0A8C0QEK7
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9615:CDK8
gene id: 9615:CDK8
uniprot id: A0A8C0NY66
uniprot id: A0A8C0TAA0
uniprot id: A0A8I3PYQ8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:SOHLH2
gene id: 9615:SOHLH2
uniprot id: A0A8C0S6L0
uniprot id: A0A8I3Q0N1
names: Subcellular Location Annotation
messages: Nucleus

9615:ACOX3
gene id: 9615:ACOX3
uniprot id: A0A8P0T7N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9615:C24H20orf27
gene id: 9615:C24H20orf27
uniprot id: A0A8C0P8T9
uniprot id: A0A8I3NVB5
names: Similarity
messages: Belongs to the ADISSP family.

9615:S100G
gene id: 9615:S100G
uniprot id: A0A8C0SKA9
names: Similarity
messages: Belongs to the S-100 family.

9615:LOC102155967
gene id: 9615:LOC102155967
uniprot id: A0A8C0RZI9
uniprot id: A0A8I3PIY0
names: Similarity
messages: Belongs to the MS4A family.

9615:TM9SF3
gene id: 9615:TM9SF3
uniprot id: A0A8C0Z6H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9615:LITAF
gene id: 9615:LITAF
uniprot id: A0A8C0Q164
uniprot id: A0A8I3NQ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9615:ACTRT3
gene id: 9615:ACTRT3
uniprot id: A0A8C0PJ23
uniprot id: A0A8I3S1W2
names: Similarity
messages: Belongs to the actin family.

9615:PPP2R2D
gene id: 9615:PPP2R2D
uniprot id: A0A8C0Z5G2
uniprot id: A0A8I3PY31
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9615:LIPT2
gene id: 9615:LIPT2
uniprot id: A0A8C0T0W4
uniprot id: A0A8I3N0Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

9615:RBM17
gene id: 9615:RBM17
uniprot id: A0A8C0LVF0
uniprot id: A0A8I3MLP9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9615:ACAT2
gene id: 9615:ACAT2
uniprot id: A0A8C0NFX7
uniprot id: A0A8I3N041
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9615:CDH19
gene id: 9615:CDH19
uniprot id: A0A8I3MEQ3
uniprot id: A0A8P0S5Y5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9615:G6PC2
gene id: 9615:G6PC2
uniprot id: A0A8C0P8I7
uniprot id: A0A8I3PK19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9615:NOG
gene id: 9615:NOG
uniprot id: E2RVU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9615:GJA1
gene id: 9615:GJA1
uniprot id: A0A654IEC4
uniprot id: A0A8P0T9K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles.
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:KRT71
gene id: 9615:KRT71
uniprot id: D6BR72
names: Similarity
messages: Belongs to the intermediate filament family.

9615:ARHGDIA
gene id: 9615:ARHGDIA
uniprot id: A0A8C0NLL3
names: Similarity
messages: Belongs to the Rho GDI family.

9615:CDC5L
gene id: 9615:CDC5L
uniprot id: A0A8C0YW82
uniprot id: A0A8I3NKY0
names: Similarity
messages: Belongs to the CEF1 family.

9615:PDE6A
gene id: 9615:PDE6A
uniprot id: Q28263
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Cell membrane
messages: Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
messages: Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP. This protein participates in processes of transmission and amplification of the visual signal.
messages: photoreceptor outer segment

9615:CMKLR1
gene id: 9615:CMKLR1
uniprot id: A0A8I3Q1X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9615:TMEM126B
gene id: 9615:TMEM126B
uniprot id: A0A8C0TI18
names: Subcellular Location Annotation
messages: Membrane

9615:CANT1
gene id: 9615:CANT1
uniprot id: A0A8C0PWZ5
uniprot id: A0A8C0RBN6
uniprot id: A0A8C0RWU9
uniprot id: A0A8I3NVL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apyrase family.
messages: Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
messages: extracellular matrix

9615:DRC7
gene id: 9615:DRC7
uniprot id: A0A8C0M4M1
uniprot id: A0A8I3MM11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

9615:CTSW
gene id: 9615:CTSW
uniprot id: A0A8C0SR41
uniprot id: A0A8I3NT28
names: Similarity
messages: Belongs to the peptidase C1 family.

9615:KCNJ6
gene id: 9615:KCNJ6
uniprot id: A0A8C0TE53
uniprot id: A0A8I3PXZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9615:AP2S1
gene id: 9615:AP2S1
uniprot id: A0A8C0REP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

9615:FABP1
gene id: 9615:FABP1
uniprot id: A0A8C0SNT4
uniprot id: A0A8I3ND57
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9615:RPS6KA4
gene id: 9615:RPS6KA4
uniprot id: A0A8C0RIW5
uniprot id: A0A8I3Q6K1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9615:ACAT1
gene id: 9615:ACAT1
uniprot id: A0A8C0YWR8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9615:CDCA7L
gene id: 9615:CDCA7L
uniprot id: A0A8C0PN79
uniprot id: A0A8C0Q6I7
uniprot id: A0A8I3NA84
uniprot id: A0A8I3RUD1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:RHCE
gene id: 9615:RHCE
uniprot id: A0A8C0LVI2
uniprot id: Q3BCQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9615:ASF1A
gene id: 9615:ASF1A
uniprot id: A0A8C0RXM1
uniprot id: A0A8I3NGT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9615:MEGF10
gene id: 9615:MEGF10
uniprot id: A0A8I3NCL3
uniprot id: A0A8P0TBH0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:STX12
gene id: 9615:STX12
uniprot id: A0A8C0RHL7
uniprot id: A0A8I3NIZ9
names: Similarity
messages: Belongs to the syntaxin family.

9615:PRNP
gene id: 9615:PRNP
uniprot id: O46593
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane

9615:PLPPR1
gene id: 9615:PLPPR1
uniprot id: A0A8C0QIL3
uniprot id: A0A8I3NA99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9615:RUVBL1
gene id: 9615:RUVBL1
uniprot id: A0A8I3P6G1
uniprot id: A0A8P0N702
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9615:FGF12
gene id: 9615:FGF12
uniprot id: A0A8C0NL09
uniprot id: A0A8C0TAM1
uniprot id: A0A8I3PPX4
uniprot id: J9P2J7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:CYP4A38
gene id: 9615:CYP4A38
uniprot id: Q2VHZ8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:MOXD1
gene id: 9615:MOXD1
uniprot id: A0A8C0MDM3
uniprot id: A0A8I3MSP1
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

9615:PDP2
gene id: 9615:PDP2
uniprot id: A0A8I3NTB1
uniprot id: A0A8P0SP07
names: Similarity
messages: Belongs to the PP2C family.

9615:KHDRBS3
gene id: 9615:KHDRBS3
uniprot id: A0A8C0Q9I0
uniprot id: A0A8C0Q9T8
uniprot id: A0A8I3NCN4
uniprot id: A0A8I3RYF3
names: Similarity
messages: Belongs to the KHDRBS family.

9615:BANF1
gene id: 9615:BANF1
uniprot id: A0A8C0SLN6
uniprot id: A0A8I3NSQ5
names: Subcellular Location Annotation
messages: Nucleus

9615:ADGRE5
gene id: 9615:ADGRE5
uniprot id: A0A8P0PAT6
uniprot id: Q2Q423
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:CRYBB3
gene id: 9615:CRYBB3
uniprot id: A0A8C0RU73
uniprot id: A0A8I3Q2C3
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9615:CRYBA4
gene id: 9615:CRYBA4
uniprot id: A2ICR5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).

9615:IPPK
gene id: 9615:IPPK
uniprot id: A0A8C0M0Y0
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9615:CUL9
gene id: 9615:CUL9
uniprot id: A0A8C0N1E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9615:SNU13
gene id: 9615:SNU13
uniprot id: A0A8C0SUV3
uniprot id: A0A8I3NPM0
uniprot id: A0A8I3P795
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9615:SHMT2
gene id: 9615:SHMT2
uniprot id: A0A8C0MTK9
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9615:ACTR3B
gene id: 9615:ACTR3B
uniprot id: A0A8I3NGR4
uniprot id: A0A8P0NPJ4
names: Similarity
messages: Belongs to the actin family.

9615:OSBPL7
gene id: 9615:OSBPL7
uniprot id: A0A8P0NI45
names: Similarity
messages: Belongs to the OSBP family.

9615:NKX6-1
gene id: 9615:NKX6-1
uniprot id: A0A8C0MX83
uniprot id: A0A8I3PA23
names: Subcellular Location Annotation
messages: Nucleus

9615:CXCR6
gene id: 9615:CXCR6
uniprot id: A0A8C0T4E2
uniprot id: A0A8I3RWZ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:SLC13A2
gene id: 9615:SLC13A2
uniprot id: A0A8C0TCV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9615:OLR1
gene id: 9615:OLR1
uniprot id: A0A8C0NTJ7
uniprot id: A0A8I3QC57
names: Subcellular Location Annotation
messages: Membrane

9615:FPR2
gene id: 9615:FPR2
uniprot id: A0A8C0LUD1
uniprot id: A0A8I3MRI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

9615:ADCK2
gene id: 9615:ADCK2
uniprot id: A0A8C0QCS1
uniprot id: A0A8I3Q606
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9615:BAG6
gene id: 9615:BAG6
uniprot id: A0A8C0MI66
uniprot id: A0A8C0S6N0
uniprot id: A0A8C0S773
uniprot id: A0A8I3NHV1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: cytosol
messages: extracellular exosome

9615:MYOZ3
gene id: 9615:MYOZ3
uniprot id: A0A8C0QHL9
uniprot id: A0A8C0QRR8
uniprot id: A0A8I3MZW2
names: Similarity
messages: Belongs to the myozenin family.

9615:PISD
gene id: 9615:PISD
uniprot id: A0A8C0TNS6
uniprot id: A0A8C0TP12
uniprot id: A0A8I3PTL0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9615:KCNJ3
gene id: 9615:KCNJ3
uniprot id: A0A8C0SF56
uniprot id: A0A8I3PT84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

9615:POLR1E
gene id: 9615:POLR1E
uniprot id: A0A8C0MLU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9615:ENTPD3
gene id: 9615:ENTPD3
uniprot id: A0A8C0RIZ1
uniprot id: A0A8I3P1J9
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9615:TOM1
gene id: 9615:TOM1
uniprot id: A0A8C0RE13
uniprot id: A0A8I3RVJ5
names: Similarity
messages: Belongs to the TOM1 family.

9615:SMG8
gene id: 9615:SMG8
uniprot id: A0A8C0MJW9
uniprot id: A0A8I3PWU0
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

9615:CENPM
gene id: 9615:CENPM
uniprot id: A0A8C0ST46
uniprot id: A0A8I3P5M5
names: Subcellular Location Annotation
messages: Nucleus

9615:OR52H9
gene id: 9615:OR52H9
uniprot id: A0A8C0T0E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:LOC612523
gene id: 9615:LOC612523
uniprot id: A0A8P0TM71
names: Subcellular Location Annotation
messages: Nucleus

9615:FAM187A
gene id: 9615:FAM187A
uniprot id: A0A8C0MFG8
uniprot id: A0A8I3N351
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9615:AK1
gene id: 9615:AK1
uniprot id: A0A8C0N8N8
uniprot id: B4YY02
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

9615:SNX17
gene id: 9615:SNX17
uniprot id: A0A8C0S6S6
uniprot id: A0A8I3N647
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9615:RPA2
gene id: 9615:RPA2
uniprot id: A0A8P0TDG2
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

9615:TJAP1
gene id: 9615:TJAP1
uniprot id: A0A8C0QEF6
uniprot id: A0A8P0PDN3
names: Subcellular Location Annotation
messages: Membrane

9615:HBS1L
gene id: 9615:HBS1L
uniprot id: A0A8C0MAR0
uniprot id: A0A8C0MBD6
uniprot id: A0A8I3MZC3
names: Subcellular Location Annotation
messages: Cytoplasm

9615:MRPL41
gene id: 9615:MRPL41
uniprot id: A0A8C0MD63
uniprot id: A0A8I3PES4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

9615:EIPR1
gene id: 9615:EIPR1
uniprot id: A0A8C0NV24
uniprot id: A0A8I3PK85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EIPR1 family.
messages: trans-Golgi network

9615:GSK3B
gene id: 9615:GSK3B
uniprot id: A0A8C0MPF2
uniprot id: A0A8C0T8A0
uniprot id: A0A8P0NMG8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9615:MYO1E
gene id: 9615:MYO1E
uniprot id: A0A8C0N2D5
uniprot id: A0A8I3NQ19
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9615:LMX1A
gene id: 9615:LMX1A
uniprot id: A0A8C0P6V3
uniprot id: A0A8I3PJV5
names: Subcellular Location Annotation
messages: Nucleus

9615:SNX20
gene id: 9615:SNX20
uniprot id: A0A8C0MTS2
uniprot id: A0A8I3N7A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Membrane

9615:OLFML3
gene id: 9615:OLFML3
uniprot id: A0A8C0PP62
uniprot id: A0A8I3PPB1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:RHBDD3
gene id: 9615:RHBDD3
uniprot id: A0A8C0T5V8
uniprot id: A0A8I3Q708
names: Subcellular Location Annotation
messages: Membrane

9615:SENP8
gene id: 9615:SENP8
uniprot id: A0A8C0NLX5
uniprot id: A0A8I3PIP6
names: Similarity
messages: Belongs to the peptidase C48 family.

9615:PTPRB
gene id: 9615:PTPRB
uniprot id: A0A8P0N3P5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

9615:NDUFA11
gene id: 9615:NDUFA11
uniprot id: A0A8C0PBD9
uniprot id: A0A8I3NKQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Mitochondrion inner membrane

9615:RFC4
gene id: 9615:RFC4
uniprot id: A0A8C0T1X4
uniprot id: A0A8I3PDB8
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9615:LRTOMT
gene id: 9615:LRTOMT
uniprot id: A0A8C0MZ85
uniprot id: A0A8I3NFY4
names: Subcellular Location Annotation
messages: Cytoplasm

9615:TMEM94
gene id: 9615:TMEM94
uniprot id: A0A8C0PVV6
uniprot id: A0A8C0PWK6
uniprot id: A0A8I3PWE3
names: Subcellular Location Annotation
messages: Membrane

9615:NECAP1
gene id: 9615:NECAP1
uniprot id: A0A8C0P5X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9615:SLC43A1
gene id: 9615:SLC43A1
uniprot id: A0A8C0ML92
uniprot id: E2QXB4
names: Subcellular Location Annotation
messages: Membrane

9615:SNRPD3
gene id: 9615:SNRPD3
uniprot id: A0A8C0P7E3
uniprot id: A0A8I3PG61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9615:SLC10A6
gene id: 9615:SLC10A6
uniprot id: A0A8C0REE4
uniprot id: A0A8I3PJ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9615:HOXD3
gene id: 9615:HOXD3
uniprot id: A0A8C0P1F4
uniprot id: A0A8I3NYG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:NAV2
gene id: 9615:NAV2
uniprot id: A0A8I3P2L4
uniprot id: A0A8I3P705
uniprot id: A0A8P0PGG9
uniprot id: A0A8P0PHT2
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9615:UGT2B31
gene id: 9615:UGT2B31
uniprot id: Q6K1J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs.

9615:POLR3GL
gene id: 9615:POLR3GL
uniprot id: A0A8C0M980
uniprot id: A0A8I3RYJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9615:FNIP1
gene id: 9615:FNIP1
uniprot id: A0A8C0SIT7
uniprot id: A0A8C0SK02
uniprot id: A0A8I3NKW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9615:NUDCD1
gene id: 9615:NUDCD1
uniprot id: A0A8I3NEV1
uniprot id: A0A8P0N3Z1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:CZIB
gene id: 9615:CZIB
uniprot id: A0A8C0RVH1
names: Similarity
messages: Belongs to the UPF0587 family.

9615:ST6GALNAC4
gene id: 9615:ST6GALNAC4
uniprot id: A0A8C0N9Q3
uniprot id: A0A8I3MSL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:WWOX
gene id: 9615:WWOX
uniprot id: A0A8C0RAF0
uniprot id: A0A8C0S3P8
uniprot id: A0A8I3PBQ7
uniprot id: A0A8I3PHM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Lysosome
messages: Mitochondrion

9615:ARSG
gene id: 9615:ARSG
uniprot id: Q32KH9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate (By similarity). Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin (By similarity).
messages: Lysosome
messages: N-glycosylated with both high mannose and complex type sugars.
messages: The 63-kDa precursor undergoes proteolytic processing in two steps, yielding two fragments in the first step (apparent molecular masses of 44 and 18 kDa) (By similarity). In the second step, the 44-kDa fragment is processed further to the 34- and 10-kDa chains. The 10-kDa chain is a cleavage product of the 44-kDa fragment but linked to the 18-kDa chain through a disulfide bridge (By similarity).
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:MAOB
gene id: 9615:MAOB
uniprot id: Q7YRB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).

9615:LHX3
gene id: 9615:LHX3
uniprot id: E0X4D7
names: Subcellular Location Annotation
messages: Nucleus

9615:INHBC
gene id: 9615:INHBC
uniprot id: A0A8I3N9C1
uniprot id: A0A8P0PJK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9615:DDX1
gene id: 9615:DDX1
uniprot id: A0A8C0NB32
uniprot id: A0A8I3NV96
uniprot id: A0A8I3S1S5
uniprot id: A0A8P0P5Y7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule
messages: RNA helicase.
messages: The helicase domain is involved in the stimulation of RELA transcriptional activity.

9615:PCNP
gene id: 9615:PCNP
uniprot id: A0A8I3PAS2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UHRF2/NIRF.
messages: May be involved in cell cycle regulation.
messages: Nucleus

9615:PTCH2
gene id: 9615:PTCH2
uniprot id: A0A8P0SAB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9615:BUD23
gene id: 9615:BUD23
uniprot id: A0A8C0RIP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

9615:INHBE
gene id: 9615:INHBE
uniprot id: A0A8C0SGB0
uniprot id: A0A8I3NAL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9615:LOC100855430
gene id: 9615:LOC100855430
uniprot id: A0A8C0P6T5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9615:TFF1
gene id: 9615:TFF1
uniprot id: Q863T4
names: Function
names: Subcellular Location Annotation
messages: Secreted
messages: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.

9615:INA
gene id: 9615:INA
uniprot id: A0A8C0TR21
uniprot id: A0A8I3PZW8
names: Similarity
messages: Belongs to the intermediate filament family.

9615:MTIF3
gene id: 9615:MTIF3
uniprot id: A0A8I3PVH2
uniprot id: A0A8P0SC81
names: Similarity
messages: Belongs to the IF-3 family.

9615:HTR1B
gene id: 9615:HTR1B
uniprot id: P79250
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A residue in the 7th transmembrane region ('Thr-355' in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).
messages: Homodimer. Heterodimer with HTR1D (By similarity).
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Palmitoylated.
messages: Phosphorylated.

9615:CSK
gene id: 9615:CSK
uniprot id: A0A8C0RH82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:CYP8B1
gene id: 9615:CYP8B1
uniprot id: A0A8C0NR21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9615:OSBPL8
gene id: 9615:OSBPL8
uniprot id: A0A8C0QBV1
uniprot id: A0A8I3RUP7
uniprot id: A0A8P0T2B0
names: Similarity
messages: Belongs to the OSBP family.

9615:MOCOS
gene id: 9615:MOCOS
uniprot id: A0A8I3RS50
uniprot id: A0A8P0NJ23
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

9615:AWAT1
gene id: 9615:AWAT1
uniprot id: A0A8C0TH09
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:EXOC6B
gene id: 9615:EXOC6B
uniprot id: A0A8C0PFZ9
uniprot id: A0A8C0RS33
uniprot id: A0A8I3P546
uniprot id: A0A8I3PGI4
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9615:SH3BP5L
gene id: 9615:SH3BP5L
uniprot id: A0A8C0RFD0
uniprot id: A0A8I3NE54
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9615:CMTR1
gene id: 9615:CMTR1
uniprot id: A0A8C0RGQ1
uniprot id: A0A8I3NDU6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

9615:IL4
gene id: 9615:IL4
uniprot id: O77762
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
messages: Secreted

9615:CRH
gene id: 9615:CRH
uniprot id: A0A8C0NFE2
uniprot id: A0A8I3PCJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9615:TAP2
gene id: 9615:TAP2
uniprot id: H8ZYY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

9615:SAMD8
gene id: 9615:SAMD8
uniprot id: A0A8C0RWC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9615:SNAP25
gene id: 9615:SNAP25
uniprot id: A0A8C0QNH3
uniprot id: A0A8C0RZD7
uniprot id: A0A8I3PMC0
uniprot id: A0A8I3PWK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9615:MYOD1
gene id: 9615:MYOD1
uniprot id: A0A8C0TH61
uniprot id: A0A8I3NJT4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9615:KCND1
gene id: 9615:KCND1
uniprot id: A0A8C0S6M9
uniprot id: A0A8I3Q626
uniprot id: A0A8P0SK49
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

9615:TSEN2
gene id: 9615:TSEN2
uniprot id: A0A8C0TFY8
uniprot id: A0A8I3Q1M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9615:NOL6
gene id: 9615:NOL6
uniprot id: A0A8C0QDY3
uniprot id: A0A8I3PBI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: nucleolus

9615:GPRC5C
gene id: 9615:GPRC5C
uniprot id: A0A8C0M621
uniprot id: A0A8I3S0J1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:NKIRAS2
gene id: 9615:NKIRAS2
uniprot id: A0A8C0S1Q6
uniprot id: A0A8I3N5X1
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9615:HPS5
gene id: 9615:HPS5
uniprot id: A0A8C0TJ35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

9615:MRPS26
gene id: 9615:MRPS26
uniprot id: A0A8C0STU7
uniprot id: A0A8I3S1G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9615:LOC476602
gene id: 9615:LOC476602
uniprot id: A0A8C0TH41
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm

9615:MFSD14B
gene id: 9615:MFSD14B
uniprot id: A0A8C0LTI5
uniprot id: A0A8I3MA19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9615:ARSF
gene id: 9615:ARSF
uniprot id: A0A8P0ND70
names: Similarity
messages: Belongs to the sulfatase family.

9615:IMPDH2
gene id: 9615:IMPDH2
uniprot id: A0A8C0Z3I3
uniprot id: A0A8I3Q7R1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9615:UPF3B
gene id: 9615:UPF3B
uniprot id: A0A8C0SRA6
uniprot id: A0A8C0SRB0
names: Similarity
messages: Belongs to the RENT3 family.

9615:TLR7
gene id: 9615:TLR7
uniprot id: Q2L4T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
messages: Lysosome
messages: Membrane
messages: phagosome

9615:GKAP1
gene id: 9615:GKAP1
uniprot id: A0A8C0RVD2
uniprot id: A0A8I3MXP2
names: Similarity
messages: Belongs to the GKAP1 family.

9615:HCAR1
gene id: 9615:HCAR1
uniprot id: A0A8C0TPD8
uniprot id: B9UM26
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:LOC100686340
gene id: 9615:LOC100686340
uniprot id: A0A8C0S116
uniprot id: A0A8I3N0M4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9615:GUCY1B1
gene id: 9615:GUCY1B1
uniprot id: Q4ZHR9
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by nitric oxide in the presence of magnesium or manganese ions.
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer. Heme is required for responding to nitric oxide, but not for catalytic activity.
messages: Cytoplasm
messages: Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
messages: The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1A1. Can also form inactive homodimers in vitro.
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

9615:CRLS1
gene id: 9615:CRLS1
uniprot id: A0A8C0QQU9
uniprot id: A0A8I3PTZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9615:FGF22
gene id: 9615:FGF22
uniprot id: A0A8C0PBB6
uniprot id: A0A8I3NYK3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:LPIN1
gene id: 9615:LPIN1
uniprot id: A0A8I3Q115
uniprot id: A0A8I3Q2F0
uniprot id: A0A8I3SBU5
uniprot id: A0A8P0NY02
uniprot id: A0A8P0SYU3
names: Similarity
messages: Belongs to the lipin family.

9615:HPN
gene id: 9615:HPN
uniprot id: A0A8C0RWA3
uniprot id: A0A8I3RRL2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:AHCYL2
gene id: 9615:AHCYL2
uniprot id: A0A8C0PHF7
uniprot id: A0A8C0S5X6
uniprot id: A0A8C0YU80
uniprot id: A0A8I3PDP1
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

9615:ATP5PO
gene id: 9615:ATP5PO
uniprot id: A0A8C0T488
uniprot id: J9P621
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9615:PPME1
gene id: 9615:PPME1
uniprot id: A0A8P0SB29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Binds PPP2CA and PPP2CB.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

9615:DPH1
gene id: 9615:DPH1
uniprot id: A0A8C0Q0Q9
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.

9615:AQP2
gene id: 9615:AQP2
uniprot id: A0A8C0PGG7
uniprot id: A0A8I3P6A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9615:CX3CL1
gene id: 9615:CX3CL1
uniprot id: A0A8C0YVN8
uniprot id: E2RTH0
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9615:ATP1A4
gene id: 9615:ATP1A4
uniprot id: A0A8C0NIT5
uniprot id: A0A8I3QZ68
uniprot id: A0A8P0NEC8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:CLTCL1
gene id: 9615:CLTCL1
uniprot id: A0A8C0SZX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9615:UQCC1
gene id: 9615:UQCC1
uniprot id: A0A8C0P9S5
uniprot id: A0A8C0QEE5
uniprot id: A0A8I3P513
uniprot id: A0A8I3P9D9
uniprot id: A0A8P0SD86
names: Similarity
messages: Belongs to the CBP3 family.

9615:TNNT2
gene id: 9615:TNNT2
uniprot id: A0A8P0TUB7
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9615:ACTN2
gene id: 9615:ACTN2
uniprot id: A0A8C0MXP0
names: Similarity
messages: Belongs to the alpha-actinin family.

9615:IFT20
gene id: 9615:IFT20
uniprot id: A0A8C0N7T2
uniprot id: A0A8I3NWB5
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9615:ALDOB
gene id: 9615:ALDOB
uniprot id: A0A8C0QJ05
uniprot id: A0A8I3N760
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9615:SQLE
gene id: 9615:SQLE
uniprot id: A0A8C0MWQ3
uniprot id: A0A8I3NFI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9615:KLHL21
gene id: 9615:KLHL21
uniprot id: A0A8C0MLH8
uniprot id: A0A8I3PSB9
names: Subcellular Location Annotation
messages: spindle

9615:GLCE
gene id: 9615:GLCE
uniprot id: A0A8I3PE77
uniprot id: A0A8P0TUB9
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9615:RHBDF2
gene id: 9615:RHBDF2
uniprot id: Q00M95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S54 family.
messages: Cell membrane
messages: Detected in retina and spleen.
messages: Endoplasmic reticulum membrane
messages: Interacts with EGF (By similarity). Interacts (via cytoplasmic N-terminus) with FRMD8/iTAP; this interaction leads to mutual protein stabilization. Interacts with ADAM17/TACE (By similarity).
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

9615:ADM
gene id: 9615:ADM
uniprot id: O77559
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: AM and PAMP are potent hypotensive and vasodilatator agents.
messages: Belongs to the adrenomedullin family.
messages: Secreted

9615:GNA14
gene id: 9615:GNA14
uniprot id: A0A8C0RAR4
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9615:ADAMDEC1
gene id: 9615:ADAMDEC1
uniprot id: A0A8C0TDS7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CEP20
gene id: 9615:CEP20
uniprot id: A0A8C0PT45
uniprot id: A0A8C0PXG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9615:SULT1C3
gene id: 9615:SULT1C3
uniprot id: A0A8P0N557
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:PPP1R3C
gene id: 9615:PPP1R3C
uniprot id: A0A8C0T1I3
uniprot id: A0A8I3Q3Y6
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9615:SLC27A6
gene id: 9615:SLC27A6
uniprot id: A0A8C0P495
uniprot id: A0A8I3N4Y3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:DCLRE1C
gene id: 9615:DCLRE1C
uniprot id: A0A8C0Q8T6
uniprot id: A0A8I3P3Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9615:SF3A2
gene id: 9615:SF3A2
uniprot id: A0A8C0MT68
uniprot id: A0A8I3NBJ0
names: Similarity
messages: Belongs to the SF3A2 family.

9615:NAV1
gene id: 9615:NAV1
uniprot id: A0A8C0LVJ7
uniprot id: A0A8I3NSM0
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9615:H2AW
gene id: 9615:H2AW
uniprot id: A0A8C0QMK5
uniprot id: A0A8I3N3A0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:GALM
gene id: 9615:GALM
uniprot id: A0A8C0TUM9
uniprot id: A0A8I3PB48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

9615:SLC25A23
gene id: 9615:SLC25A23
uniprot id: A0A8C0TNG6
uniprot id: A0A8I3N616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:L3HYPDH
gene id: 9615:L3HYPDH
uniprot id: A0A8C0Q5Y1
uniprot id: A0A8I3P9F0
names: Similarity
messages: Belongs to the proline racemase family.

9615:RAB7A
gene id: 9615:RAB7A
uniprot id: P18067
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasmic vesicle
messages: Deubiquitination at Lys-191 and Lys-194 by USP32.
messages: Endosome membrane
messages: Interacts with NTRK1/TRKA (By similarity). Interacts with RILP (By similarity). Interacts with PSMA7 (By similarity). Interacts with RNF115 (By similarity). Interacts with FYCO1 (By similarity). Interacts with the PIK3C3/VPS34-PIK3R4 complex (By similarity). The GTP-bound form interacts with OSBPL1A (By similarity). The GTP-bound form interacts with RAC1 (By similarity). Interacts with CLN3 (By similarity). Interacts with CHM, the substrate-binding subunit of the Rab geranylgeranyltransferase complex (By similarity). Interacts with C9orf72. Does not interact with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4). Interacts with CLN5 (By similarity). Interacts with PLEKHM1 (via N- and C-terminus) (By similarity). Interacts with RUFY4 (By similarity). Interacts with PRPH; the interaction is direct (By similarity). Interacts with VPS13A (By similarity). The GDP-bound form interacts with RIMOC1 (By similarity). Interacts with the MON1A-CCZ1B complex and this interaction is enhanced in the presence of RIMOC1 (By similarity).
messages: Late endosome membrane
messages: Lipid droplet
messages: Lysosome membrane
messages: Melanosome membrane
messages: Mitochondrion membrane
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transporter-mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By similarity). Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes (By similarity). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses (By similarity). Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium) (By similarity). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (By similarity). Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (By similarity). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation (By similarity). Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway. Required for the exosomal release of SDCBP, CD63 and syndecan (By s…
messages: autophagosome membrane
messages: phagosome membrane

9615:CYCS
gene id: 9615:CYCS
uniprot id: P00011
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).

9615:PPARGC1B
gene id: 9615:PPARGC1B
uniprot id: A0A8C0M2E3
uniprot id: A0A8I3N0I9
uniprot id: A0A8P0SMD8
names: Subcellular Location Annotation
messages: Nucleus

9615:MBOAT1
gene id: 9615:MBOAT1
uniprot id: A0A8I3NX08
uniprot id: A0A8P0NCG3
names: Subcellular Location Annotation
messages: Membrane

9615:SMARCA2
gene id: 9615:SMARCA2
uniprot id: A0A8C0Q810
uniprot id: A0A8I3RQI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9615:B3GNT5
gene id: 9615:B3GNT5
uniprot id: A0A8C0N8G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:LOC486404
gene id: 9615:LOC486404
uniprot id: A0A8C0Z298
uniprot id: A0A8I3PS21
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

9615:HRH2
gene id: 9615:HRH2
uniprot id: P17124
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Gastric fundus and, to a lesser extent, in brain.
messages: The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9615:ADAMTS9
gene id: 9615:ADAMTS9
uniprot id: A0A8C0N2W2
uniprot id: A0A8C0RIW9
uniprot id: A0A8I3NK12
uniprot id: A0A8I3NP62
uniprot id: A0A8I3NZ51
uniprot id: A0A8P0P518
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:HADH
gene id: 9615:HADH
uniprot id: A0A8P0TBX0
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9615:UBE2D2
gene id: 9615:UBE2D2
uniprot id: A0A8C0M901
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:ADNP
gene id: 9615:ADNP
uniprot id: A0A8C0SDU4
names: Subcellular Location Annotation
messages: Nucleus

9615:DLK1
gene id: 9615:DLK1
uniprot id: A0A8C0MP48
uniprot id: A0A8I3MKW6
uniprot id: A0A8I3MSX8
uniprot id: A0A8P0SM36
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:ROM1
gene id: 9615:ROM1
uniprot id: A0A8C0TB35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9615:YAE1
gene id: 9615:YAE1
uniprot id: A0A8C0M7W8
uniprot id: A0A8I3PAT7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:LOC479822
gene id: 9615:LOC479822
uniprot id: A0A8C0RUN3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:HAPLN3
gene id: 9615:HAPLN3
uniprot id: A0A8P0SGF7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:SLC35F6
gene id: 9615:SLC35F6
uniprot id: A0A8C0QK62
uniprot id: A0A8I3Q1Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9615:MLNR
gene id: 9615:MLNR
uniprot id: A0A8C0YVL1
uniprot id: B2NIZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:PLSCR5
gene id: 9615:PLSCR5
uniprot id: A0A8C0MH02
uniprot id: A0A8I3PN12
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9615:PML
gene id: 9615:PML
uniprot id: A0A8P0T268
names: Subcellular Location Annotation
messages: Cytoplasm

9615:ATP6V1B2
gene id: 9615:ATP6V1B2
uniprot id: A0A8C0PWY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9615:MRPL43
gene id: 9615:MRPL43
uniprot id: A0A8C0TA55
uniprot id: A0A8I3P6K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

9615:PLA2G5
gene id: 9615:PLA2G5
uniprot id: A0A8C0QJ08
uniprot id: A0A8I3MP63
uniprot id: A0A8I3N470
uniprot id: A0A8P0NXA2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9615:NPPB
gene id: 9615:NPPB
uniprot id: A0A8P0PRD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.
messages: Secreted

9615:CLRN2
gene id: 9615:CLRN2
uniprot id: A0A8C0RBT4
uniprot id: A0A8I3MI40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9615:TPP2
gene id: 9615:TPP2
uniprot id: A0A8C0TQ75
uniprot id: A0A8I3QCC9
names: Similarity
messages: Belongs to the peptidase S8 family.

9615:CDK10
gene id: 9615:CDK10
uniprot id: A0A8C0N0J1
uniprot id: A0A8C0PD07
uniprot id: A0A8I3MEU6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:OR52B4
gene id: 9615:OR52B4
uniprot id: G3FJF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:COG3
gene id: 9615:COG3
uniprot id: A0A8C0YZF2
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9615:SLC19A2
gene id: 9615:SLC19A2
uniprot id: A0A8C0RSH3
uniprot id: A0A8I3MT32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9615:PROX1
gene id: 9615:PROX1
uniprot id: A0A8C0MLR5
uniprot id: A0A8I3MI35
names: Subcellular Location Annotation
messages: Nucleus

9615:ST8SIA6
gene id: 9615:ST8SIA6
uniprot id: A2VBC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:RPS9
gene id: 9615:RPS9
uniprot id: A0A8C0M2M9
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9615:ENO4
gene id: 9615:ENO4
uniprot id: A0A8C0TT02
uniprot id: A0A8I3Q5Z0
names: Similarity
messages: Belongs to the enolase family.

9615:SPARC
gene id: 9615:SPARC
uniprot id: A0A8C0QBH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

9615:CYRIA
gene id: 9615:CYRIA
uniprot id: A0A8C0SA30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9615:SESN1
gene id: 9615:SESN1
uniprot id: A0A8C0N521
uniprot id: A0A8C0S7I6
uniprot id: A0A8I3NDQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9615:GJB5
gene id: 9615:GJB5
uniprot id: A0A654ICX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:LOC608697
gene id: 9615:LOC608697
uniprot id: A0A8C0PS61
uniprot id: A0A8I3PYK7
names: Similarity
messages: Belongs to the TPP enzyme family.

9615:PTGR1
gene id: 9615:PTGR1
uniprot id: A0A8C0MR59
uniprot id: A0A8I3MRC0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9615:CNOT3
gene id: 9615:CNOT3
uniprot id: A0A8C0LWB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
messages: Nucleus
messages: P-body

9615:LLGL2
gene id: 9615:LLGL2
uniprot id: A0A8P0N7N2
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

9615:GPR65
gene id: 9615:GPR65
uniprot id: A0A8C0MC90
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:UPK1A
gene id: 9615:UPK1A
uniprot id: A0A8C0MF92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:MASP1
gene id: 9615:MASP1
uniprot id: A0A8C0NS70
uniprot id: A0A8C0NV46
uniprot id: A0A8C0P4N4
uniprot id: A0A8I3PF98
uniprot id: A0A8I3PJ55
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:STMN2
gene id: 9615:STMN2
uniprot id: A0A8C0N0K4
uniprot id: A0A8I3Q724
names: Similarity
messages: Belongs to the stathmin family.

9615:ATP6V1D
gene id: 9615:ATP6V1D
uniprot id: A0A8C0RM02
uniprot id: A0A8I3MUZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

9615:FOXJ1
gene id: 9615:FOXJ1
uniprot id: A0A8C0PRJ7
uniprot id: A0A8I3P9M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FOXJ1 family.
messages: Nucleus

9615:FUT2
gene id: 9615:FUT2
uniprot id: A0A8I3MCT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

9615:CYP2J2
gene id: 9615:CYP2J2
uniprot id: A0A8C0SVW2
uniprot id: A0A8I3RT03
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:CLTB
gene id: 9615:CLTB
uniprot id: A0A8C0LZB0
uniprot id: A0A8C0Z0Y9
uniprot id: A0A8I3NLC1
uniprot id: A0A8I3NML2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9615:P2RX3
gene id: 9615:P2RX3
uniprot id: A0A8C0YYT5
uniprot id: A0A8I3S575
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9615:DNAAF3
gene id: 9615:DNAAF3
uniprot id: A0A8C0LRV0
uniprot id: A0A8I3MEI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF3 family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.

9615:AZIN2
gene id: 9615:AZIN2
uniprot id: A0A8C0T507
uniprot id: A0A8I3MN71
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9615:ARHGAP26
gene id: 9615:ARHGAP26
uniprot id: A0A8C0M1N6
uniprot id: A0A8C0MBC2
uniprot id: A0A8C0MBG2
uniprot id: A0A8I3P6T2
uniprot id: A0A8I3S3A5
uniprot id: A0A8I3S3E6
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9615:EEF1AKMT1
gene id: 9615:EEF1AKMT1
uniprot id: A0A8C0Z5V1
uniprot id: A0A8I3PHI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

9615:AP1S1
gene id: 9615:AP1S1
uniprot id: A0A8C0P5V2
uniprot id: A0A8I3MGM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9615:PHKG2
gene id: 9615:PHKG2
uniprot id: A0A8C0SFP4
uniprot id: A0A8I3NJX4
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9615:VNN1
gene id: 9615:VNN1
uniprot id: Q9TSX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
messages: Cell membrane
messages: Monomer.

9615:RELL1
gene id: 9615:RELL1
uniprot id: A0A8C0PKS8
uniprot id: A0A8C0RBX4
names: Similarity
messages: Belongs to the RELT family.

9615:SNRPA1
gene id: 9615:SNRPA1
uniprot id: A0A8C0M2V0
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9615:USP48
gene id: 9615:USP48
uniprot id: A0A8I3MDT7
uniprot id: A0A8P0NGP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

9615:SMPDL3B
gene id: 9615:SMPDL3B
uniprot id: A0A8C0PW37
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9615:RNPEP
gene id: 9615:RNPEP
uniprot id: A0A8C0LWF7
uniprot id: A0A8I3NUR2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9615:RGS5
gene id: 9615:RGS5
uniprot id: A0A8C0P6I1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9615:COL4A5
gene id: 9615:COL4A5
uniprot id: Q28247
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A defect in COL4A5 has been found to be the cause of canine X-linked hereditary nephritis (HN), a disease similar to that in humans (also referred to as Alport syndrome) characterized by progressive renal failure and neurosensory deafness.
messages: Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.
messages: Belongs to the type IV collagen family.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.
messages: There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
messages: basement membrane

9615:DCTN4
gene id: 9615:DCTN4
uniprot id: A0A8C0M733
uniprot id: A0A8C0S0Y8
uniprot id: A0A8I3MS09
uniprot id: A0A8I3N2P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: cell cortex
messages: centrosome
messages: sarcomere
messages: stress fiber

9615:ARFGEF2
gene id: 9615:ARFGEF2
uniprot id: A0A8C0S2D9
uniprot id: A0A8I3S7J1
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9615:CRCP
gene id: 9615:CRCP
uniprot id: A0A8C0LR41
uniprot id: A0A8I3NQR9
uniprot id: A0A8P0SFW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9615:OR7R1
gene id: 9615:OR7R1
uniprot id: A0A8C0TJL4
uniprot id: A0A8I3Q490
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:KHDC4
gene id: 9615:KHDC4
uniprot id: A0A8C0RUJ0
uniprot id: A0A8I3NI99
names: Similarity
messages: Belongs to the KHDC4 family.

9615:TCN2
gene id: 9615:TCN2
uniprot id: A0A8C0RQ11
uniprot id: A0A8I3PAV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9615:PARP11
gene id: 9615:PARP11
uniprot id: A0A8C0TQ51
uniprot id: A0A8I3Q7F1
names: Similarity
messages: Belongs to the ARTD/PARP family.

9615:MEP1A
gene id: 9615:MEP1A
uniprot id: A0A8C0SJ13
uniprot id: A0A8I3S000
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:OR6B9
gene id: 9615:OR6B9
uniprot id: A0A8C0RK17
uniprot id: G3FJA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:MZF1
gene id: 9615:MZF1
uniprot id: A0A8C0PX77
uniprot id: A0A8P0SVZ4
names: Subcellular Location Annotation
messages: Nucleus

9615:NRP2
gene id: 9615:NRP2
uniprot id: A0A8C0MSC3
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:ERGIC1
gene id: 9615:ERGIC1
uniprot id: A0A8C0PRQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9615:MAPK3
gene id: 9615:MAPK3
uniprot id: A0A8C0RUD1
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola
messages: focal adhesion

9615:NAP1L3
gene id: 9615:NAP1L3
uniprot id: A0A8C0MLC8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9615:KLK2
gene id: 9615:KLK2
uniprot id: P09582
names: Function
names: Induction
names: Similarity
messages: Belongs to the peptidase S1 family. Kallikrein subfamily.
messages: By androgens.
messages: This serine protease is found in dog seminal plasma, its exact physiological function is not known.

9615:HIKESHI
gene id: 9615:HIKESHI
uniprot id: A0A8C0TF55
uniprot id: A0A8I3N0H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9615:OR11H7
gene id: 9615:OR11H7
uniprot id: A0A8C0MW32
uniprot id: A0A8I3PLR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ADGRG5
gene id: 9615:ADGRG5
uniprot id: A0A8C0YUN4
uniprot id: A0A8I3MGY9
uniprot id: A0A8P0SUK7
names: Subcellular Location Annotation
messages: Membrane

9615:LAPTM5
gene id: 9615:LAPTM5
uniprot id: A0A8C0MCN8
uniprot id: A0A8I3RVC2
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9615:FOXN2
gene id: 9615:FOXN2
uniprot id: A0A8C0SFC2
uniprot id: A0A8I3MWA0
names: Subcellular Location Annotation
messages: Nucleus

9615:HSD17B10
gene id: 9615:HSD17B10
uniprot id: A0A8C0MXS2
uniprot id: A0A8I3Q7T6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:YES1
gene id: 9615:YES1
uniprot id: A0A8C0PUT1
uniprot id: A0A8I3MFD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:SUFU
gene id: 9615:SUFU
uniprot id: A0A8C0PCL8
uniprot id: A0A8I3PTN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

9615:RNASE10
gene id: 9615:RNASE10
uniprot id: A0A8C0MLQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9615:IL17RC
gene id: 9615:IL17RC
uniprot id: A0A8I3MYQ1
uniprot id: A0A8I3N6K3
uniprot id: A0A8I3RUP1
uniprot id: A0A8P0NM42
uniprot id: A0A8P0SAU9
uniprot id: A0A8P0TFP5
names: Subcellular Location Annotation
messages: Membrane

9615:LVRN
gene id: 9615:LVRN
uniprot id: A0A8C0SHL6
uniprot id: A0A8I3MZ41
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9615:UGT8
gene id: 9615:UGT8
uniprot id: A0A8C0P167
uniprot id: A0A8I3Q218
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9615:HS3ST5
gene id: 9615:HS3ST5
uniprot id: A0A8C0M562
uniprot id: A0A8I3PLA0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:WNT11
gene id: 9615:WNT11
uniprot id: A0A8C0NS68
uniprot id: A0A8I3RY70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9615:DNAH7
gene id: 9615:DNAH7
uniprot id: A0A8I3PLA2
uniprot id: A0A8P0NNH2
names: Similarity
messages: Belongs to the dynein heavy chain family.

9615:CEP44
gene id: 9615:CEP44
uniprot id: A0A8C0TD67
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

9615:PGGT1B
gene id: 9615:PGGT1B
uniprot id: A0A8C0MAV6
uniprot id: A0A8I3NU24
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

9615:DUSP5
gene id: 9615:DUSP5
uniprot id: A0A8C0P5F9
uniprot id: A0A8I3Q097
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9615:ZNF287
gene id: 9615:ZNF287
uniprot id: A0A8C0RUR6
uniprot id: A0A8I3MTF6
names: Subcellular Location Annotation
messages: Nucleus

9615:LSM5
gene id: 9615:LSM5
uniprot id: A0A8C0N6W8
uniprot id: A0A8I3S385
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9615:CHMP4A
gene id: 9615:CHMP4A
uniprot id: A0A8I3N241
uniprot id: A0A8P0NU42
names: Similarity
messages: Belongs to the SNF7 family.

9615:KCNA5
gene id: 9615:KCNA5
uniprot id: A0A8C0PF84
uniprot id: Q866G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

9615:TACC1
gene id: 9615:TACC1
uniprot id: A0A8C0QRQ9
uniprot id: A0A8C0RJ64
uniprot id: A0A8I3RYT9
uniprot id: A0A8P0PE58
uniprot id: A0A8P0SBC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9615:RAB38
gene id: 9615:RAB38
uniprot id: A0A8C0MYY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9615:CA6
gene id: 9615:CA6
uniprot id: Q865C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide. Its role in saliva is unknown (By similarity).
messages: Secreted

9615:GNAT1
gene id: 9615:GNAT1
uniprot id: Q28300
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (By similarity). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity).
messages: Heterotrimeric G proteins are composed of 3 subunits alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RHO. Interacts with RGS9 and PDE6G (By similarity). Interacts (when myristoylated) with UNC119; interaction is required for localization in sensory neurons (By similarity).
messages: Membrane
messages: Photoreceptor inner segment
messages: Rod.
messages: photoreceptor outer segment

9615:TARS2
gene id: 9615:TARS2
uniprot id: A0A8I3P4R1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9615:LOC102155410
gene id: 9615:LOC102155410
uniprot id: A0A8C0Q8S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9615:INO80
gene id: 9615:INO80
uniprot id: A0A8C0TVH1
uniprot id: A0A8I3SC62
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

9615:CDKL1
gene id: 9615:CDKL1
uniprot id: A0A8C0Q0M3
uniprot id: A0A8I3MR49
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:B4GAT1
gene id: 9615:B4GAT1
uniprot id: A0A8C0RM78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:GGA1
gene id: 9615:GGA1
uniprot id: A0A8C0S1V2
uniprot id: A0A8I3MXQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9615:CISD2
gene id: 9615:CISD2
uniprot id: A0A8C0TPD3
uniprot id: A0A8I3PSV3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CISD protein family. CISD2 subfamily.
messages: Binds 1 [2Fe-2S] cluster.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Mitochondrion outer membrane
messages: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy.

9615:CIAO2A
gene id: 9615:CIAO2A
uniprot id: A0A8I3PE98
uniprot id: A0A8P0NI77
names: Similarity
messages: Belongs to the MIP18 family.

9615:BABAM1
gene id: 9615:BABAM1
uniprot id: A0A8C0SQW2
uniprot id: A0A8I3PX17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

9615:ATG2B
gene id: 9615:ATG2B
uniprot id: A0A8C0MWZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9615:NUDT4
gene id: 9615:NUDT4
uniprot id: A0A8C0ND26
uniprot id: A0A8I3P6G2
uniprot id: A0A8P0TN24
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9615:PUF60
gene id: 9615:PUF60
uniprot id: A0A8C0PSV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

9615:OR11J6
gene id: 9615:OR11J6
uniprot id: A0A8C0MR54
uniprot id: G3FJD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CACNG3
gene id: 9615:CACNG3
uniprot id: A0A8C0Q0J4
uniprot id: A0A8I3MI96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9615:COQ6
gene id: 9615:COQ6
uniprot id: A0A8C0P1Y4
uniprot id: A0A8I3NH66
uniprot id: A0A8I3NR78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

9615:H3-3A
gene id: 9615:H3-3A
uniprot id: A0A8C0LQ69
uniprot id: E2R6K5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:CCDC103
gene id: 9615:CCDC103
uniprot id: A0A8C0SL01
uniprot id: A0A8I3MY38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9615:CLK2
gene id: 9615:CLK2
uniprot id: A0A8C0PHA5
uniprot id: A0A8I3NI96
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:CHD6
gene id: 9615:CHD6
uniprot id: A0A8C0MPJ2
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9615:POLR2J
gene id: 9615:POLR2J
uniprot id: A0A8C0QLW5
uniprot id: A0A8I3RS88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

9615:DPCD
gene id: 9615:DPCD
uniprot id: A0A8C0NL61
uniprot id: A0A8I3PDQ5
names: Similarity
messages: Belongs to the DPCD family.

9615:RAN
gene id: 9615:RAN
uniprot id: P62825
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation by KAT5 at Lys-134 is increased during mitosis, impairs RANGRF binding and enhances RCC1 binding. Acetylation at Lys-37 enhances the association with nuclear export components. Deacetylation of Lys-37 by SIRT7 regulates the nuclear export of NF-kappa-B subunit RELA/p65.
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Cytoplasm
messages: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation.
messages: Melanosome
messages: Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide.
messages: Monomer. Interacts with RANGAP1, which promotes RAN-mediated GTP hydrolysis. Interacts with KPNB1 (PubMed:15864302). Interaction with KPNB1 inhibits RANGAP1-mediated stimulation of GTPase activity. Interacts with RCC1 which promotes the exchange of RAN-bound GDP by GTP. Interaction with KPNB1 inhibits RCC1-mediated exchange of RAN-bound GDP by GTP. Interacts (GTP-bound form) with TNPO1; the interaction is direct. Interacts (GTP-bound form) with TNPO3; the interaction is direct (By similarity). Interacts with KPNB1 and with TNPO1; both inhibit RAN GTPase activity. Interacts (via C-terminus) with RANBP1, which alleviates the inhibition of RAN GTPase activity. Interacts with RANGRF, which promotes the release of bound guanine nucleotide. RANGRF and RCC1 compete for an overlapping binding site on RAN. Identified in a complex with KPNA2 and CSE1L; interaction with RANBP1 mediates dissociation of RAN from this complex (PubMed:15602554). Interaction with both RANBP1 and KPNA2 promotes dissociation of the complex between RAN and KPNB1. Identified in a complex composed of RAN, RANGAP1 and RANBP1. Identified in a complex that contains TNPO1, RAN and RANBP1. Identified in a nuclear export complex with XPO1. Found in a nuclear export complex with RANBP3 and XPO1. Interacts with RANBP2/NUP358. Interaction with RANBP1 or RANBP2 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1 (By similarity). Found in a nuclear export complex with RAN, XPO5 and pre-miRNA (PubMed:19965479). Interacts (GTP-bound form) with XPO5 (PubMed:19965479). Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with RANBP9 and RANBP10. Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle. Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TE…
messages: Nucleus
messages: Nucleus envelope
messages: cytosol

9615:ANO2
gene id: 9615:ANO2
uniprot id: A0A8C0TQ01
uniprot id: A0A8I3S7J5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:MRPL35
gene id: 9615:MRPL35
uniprot id: A0A8C0MRZ0
uniprot id: A0A8I3NZR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9615:GTF3C5
gene id: 9615:GTF3C5
uniprot id: A0A8P0SNI4
names: Subcellular Location Annotation
messages: Nucleus

9615:PPFIA4
gene id: 9615:PPFIA4
uniprot id: A0A8C0PTS3
uniprot id: A0A8I3NJK9
uniprot id: A0A8I3NVX1
uniprot id: A0A8P0NRY8
uniprot id: A0A8P0P3K8
uniprot id: F1PRM3
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9615:SCG5
gene id: 9615:SCG5
uniprot id: A0A8C0RNL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9615:NLGN4X
gene id: 9615:NLGN4X
uniprot id: A0A8P0SG45
uniprot id: A0A8P0TER7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9615:CLDN20
gene id: 9615:CLDN20
uniprot id: A0A8C0MMR7
uniprot id: A0A8I3MBL3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:FAM3D
gene id: 9615:FAM3D
uniprot id: A0A8C0NQ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9615:STN1
gene id: 9615:STN1
uniprot id: A0A8C0TUP0
uniprot id: A0A8I3SBD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9615:CKM
gene id: 9615:CKM
uniprot id: P05123
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Cytoplasm
messages: Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.
messages: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

9615:HSPB8
gene id: 9615:HSPB8
uniprot id: Q8MJ36
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Monomer. Interacts with HSPB1 (By similarity). Interacts with DNAJB6 (By similarity). Interacts with BAG3 (By similarity).
messages: Nucleus
messages: Phosphorylated.

9615:ADRA2B
gene id: 9615:ADRA2B
uniprot id: A0A8C0RIW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
messages: Cell membrane
messages: Membrane

9615:KCNK16
gene id: 9615:KCNK16
uniprot id: A0A8P0TRL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9615:LDHC
gene id: 9615:LDHC
uniprot id: A0A8C0TPM1
uniprot id: A0A8C0TRQ1
uniprot id: A0A8I3P2H4
uniprot id: H9N9H2
uniprot id: H9N9H3
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Belongs to the LDH/MDH superfamily. LDH family.

9615:GPC2
gene id: 9615:GPC2
uniprot id: A0A8I3RS61
uniprot id: A0A8P0NQX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9615:ACOT13
gene id: 9615:ACOT13
uniprot id: A0A8C0NJF4
uniprot id: A0A8C0TR50
uniprot id: A0A8I3P1B5
uniprot id: A0A8I3PHE5
names: Similarity
messages: Belongs to the thioesterase PaaI family.

9615:PEX1
gene id: 9615:PEX1
uniprot id: A0A8P0SQD3
uniprot id: A0A8P0TFP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: cytosol

9615:MEPCE
gene id: 9615:MEPCE
uniprot id: A0A8C0NWJ2
uniprot id: A0A8I3MJE0
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9615:SLCO6A1
gene id: 9615:SLCO6A1
uniprot id: A0A8C0NRE7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:DAD1
gene id: 9615:DAD1
uniprot id: A0A8C0PLL8
uniprot id: A0A8I3MLJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9615:FGD4
gene id: 9615:FGD4
uniprot id: A0A8C0PFI1
uniprot id: A0A8C0PKE0
uniprot id: A0A8I3P5I6
uniprot id: A0A8I3S2R6
names: Subcellular Location Annotation
messages: cytoskeleton

9615:COX7A2L
gene id: 9615:COX7A2L
uniprot id: A0A8C0N1B4
uniprot id: A0A8I3PNU0
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9615:TADA3
gene id: 9615:TADA3
uniprot id: A0A8C0MQY1
uniprot id: A0A8I3N7R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

9615:GPER1
gene id: 9615:GPER1
uniprot id: A0A8P0PQ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:PC
gene id: 9615:PC
uniprot id: A0A8I3NKZ1
uniprot id: A0A8P0PBZ5
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

9615:OR1P1
gene id: 9615:OR1P1
uniprot id: A0A8P0SNA7
uniprot id: A4GXA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:PCNX4
gene id: 9615:PCNX4
uniprot id: A0A8C0PI61
uniprot id: A0A8I3S2U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9615:TIE1
gene id: 9615:TIE1
uniprot id: A0A8C0MWH2
uniprot id: A0A8I3S459
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:PPP3R1
gene id: 9615:PPP3R1
uniprot id: A0A8C0RKV1
uniprot id: A0A8I3PQY6
uniprot id: A0A8P0TRD4
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9615:LOC611401
gene id: 9615:LOC611401
uniprot id: A0A8C0PEP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9615:IFNB1
gene id: 9615:IFNB1
uniprot id: A0A8P0N4T6
uniprot id: B6E116
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9615:STC2
gene id: 9615:STC2
uniprot id: A0A8C0RUF6
uniprot id: A0A8I3MD84
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9615:PTPA
gene id: 9615:PTPA
uniprot id: A0A8C0MNR4
uniprot id: A0A8C0S3T6
uniprot id: A0A8I3PGH2
uniprot id: A0A8I3PQ21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9615:PUS7L
gene id: 9615:PUS7L
uniprot id: A0A8P0SET6
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9615:GUCY1A1
gene id: 9615:GUCY1A1
uniprot id: Q4ZHS0
names: Activity Regulation
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by nitric oxide in the presence of magnesium or manganese ions.
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm
messages: Has also activity with Mn(2+) (in vitro).
messages: The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1B1.
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

9615:CMC1
gene id: 9615:CMC1
uniprot id: A0A8C0P0Z4
uniprot id: A0A8I3PLQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9615:AFP
gene id: 9615:AFP
uniprot id: Q8MJU5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ALB/AFP/VDB family.
messages: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin.
messages: Dimeric and trimeric forms have been found in addition to the monomeric form.
messages: Plasma.
messages: Secreted
messages: Sulfated.

9615:PSME1
gene id: 9615:PSME1
uniprot id: A0A8C0N6F6
uniprot id: A0A8I3MU16
names: Similarity
messages: Belongs to the PA28 family.

9615:ING3
gene id: 9615:ING3
uniprot id: A0A8C0NEW3
uniprot id: A0A8I3NFN6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9615:SOD2
gene id: 9615:SOD2
uniprot id: A0A346M2B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

9615:NDNF
gene id: 9615:NDNF
uniprot id: A0A8C0YZX6
uniprot id: A0A8I3PP98
names: Subcellular Location Annotation
messages: Secreted

9615:MRPL52
gene id: 9615:MRPL52
uniprot id: A0A8C0Q320
uniprot id: A0A8C0RUZ0
uniprot id: A0A8I3MEW2
uniprot id: A0A8I3RQE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

9615:NXT1
gene id: 9615:NXT1
uniprot id: A0A8P0PD31
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9615:AMH
gene id: 9615:AMH
uniprot id: A0A0E3N0I3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
messages: Secreted

9615:KCNMA1
gene id: 9615:KCNMA1
uniprot id: Q28265
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Cell membrane
messages: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation (By similarity).
messages: Expressed in all vascular and smooth muscles.
messages: Homotetramer; which constitutes the calcium-activated potassium channel. Interacts with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. Interacts with gamma subunits LRRC26, LRRC38, LRRC52 and LRRC55. Beta and gamma subunits are accessory, and modulate its activity. Interacts with RAB11B (By similarity).
messages: Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network (By similarity).
messages: Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity (By similarity).
messages: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity).
messages: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity).
messages: The S0 segment is essential for the modulation by the accessory beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4.
messages: The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
messages: The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensor regions required for activation of the channel.
messages: The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation (By similarity).
messages: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).
messages: The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel contains binding sites for Ca(2+) and Mg(2+).

9615:LZIC
gene id: 9615:LZIC
uniprot id: A0A8C0MI25
uniprot id: A0A8C0MM96
uniprot id: A0A8I3MAN6
uniprot id: A0A8P0PI55
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9615:DLA-79
gene id: 9615:DLA-79
uniprot id: Q30428
names: Similarity
messages: Belongs to the MHC class I family.

9615:CDK20
gene id: 9615:CDK20
uniprot id: A0A8C0PT11
uniprot id: A0A8I3S4M4
uniprot id: A0A8P0S838
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: cilium

9615:SHH
gene id: 9615:SHH
uniprot id: A0A8C0NU16
uniprot id: A0A8I3NQ51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9615:MCIDAS
gene id: 9615:MCIDAS
uniprot id: A0A8P0NLE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9615:FRK
gene id: 9615:FRK
uniprot id: A0A8C0S8P9
uniprot id: A0A8I3PE71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:KEAP1
gene id: 9615:KEAP1
uniprot id: A0A8C0T754
uniprot id: A0A8I3PZ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

9615:RPL21
gene id: 9615:RPL21
uniprot id: A0A8C0SAV2
uniprot id: F1PWM2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9615:INHBA
gene id: 9615:INHBA
uniprot id: A0A8C0S0W6
uniprot id: A0A8I3P2Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9615:PDE6B
gene id: 9615:PDE6B
uniprot id: P33726
names: Cofactor
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Irish setter dogs affected with rod/cone dysplasia (RCD1) contain a nonsense mutation in the gene that gives rise to a protein of 807 AA lacking 49 AA in the C-terminal.
messages: Membrane
messages: Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
messages: Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP (PubMed:8387203). Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal (By similarity).
messages: photoreceptor outer segment

9615:VPS53
gene id: 9615:VPS53
uniprot id: A0A8C0NJH5
uniprot id: A0A8I3NLI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9615:CANF2
gene id: 9615:CANF2
uniprot id: O18874
names: Allergen
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Causes an allergic reaction in human.
messages: Secreted
messages: Tongue epithelial tissue and parotid gland.

9615:PSMA8
gene id: 9615:PSMA8
uniprot id: A0A8C0PAQ8
uniprot id: A0A8I3RZP6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9615:PTPRU
gene id: 9615:PTPRU
uniprot id: A0A8I3MW46
uniprot id: A0A8I3N6Z2
uniprot id: A0A8P0NDN5
uniprot id: A0A8P0NSE2
uniprot id: A0A8P0PF37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9615:SNX10
gene id: 9615:SNX10
uniprot id: A0A8C0S1V6
uniprot id: A0A8I3NGQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9615:RPL12
gene id: 9615:RPL12
uniprot id: E2RR58
names: Function
names: PTM
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.
messages: Ubiquitinated at Lys-48 and Lys-83 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).

9615:FCGR1A
gene id: 9615:FCGR1A
uniprot id: Q7YQJ5
names: Subcellular Location Annotation
messages: Cell membrane

9615:ALDH1A2
gene id: 9615:ALDH1A2
uniprot id: A0A8C0TYR3
uniprot id: A0A8I3QC56
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:TSSK1B
gene id: 9615:TSSK1B
uniprot id: A0A8C0PCV6
uniprot id: A0A8I3S7H7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:WNT10A
gene id: 9615:WNT10A
uniprot id: A0A8C0TSA8
uniprot id: A0A8I3QPH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9615:FGD1
gene id: 9615:FGD1
uniprot id: A0A8C0TI38
names: Subcellular Location Annotation
messages: cytoskeleton

9615:LOC486150
gene id: 9615:LOC486150
uniprot id: A0A8C0TEF2
uniprot id: A0A8I3P116
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

9615:MRPL49
gene id: 9615:MRPL49
uniprot id: A0A8C0MWJ7
uniprot id: A0A8I3PZB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

9615:TIMM44
gene id: 9615:TIMM44
uniprot id: A0A8C0NHF8
uniprot id: A0A8I3SBU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

9615:HDC
gene id: 9615:HDC
uniprot id: A0A8C0T5X1
uniprot id: A0A8I3PM83
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9615:ATP6V0A2
gene id: 9615:ATP6V0A2
uniprot id: A0A8C0TK26
uniprot id: A0A8I3P989
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9615:TSHB
gene id: 9615:TSHB
uniprot id: P54828
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Indispensable for the control of thyroid structure and metabolism.
messages: Secreted

9615:SLC66A3
gene id: 9615:SLC66A3
uniprot id: A0A8C0MN56
uniprot id: A0A8I3S690
names: Subcellular Location Annotation
messages: Membrane

9615:RPS6KA6
gene id: 9615:RPS6KA6
uniprot id: A0A8I3S3E2
uniprot id: A0A8P0SLK8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9615:PDIA6
gene id: 9615:PDIA6
uniprot id: A0A8C0MEJ6
uniprot id: A0A8I3Q0F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Melanosome

9615:HSPB1
gene id: 9615:HSPB1
uniprot id: A0A8C0MMM4
uniprot id: F1PYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9615:RRH
gene id: 9615:RRH
uniprot id: A0A8I3Q2A7
uniprot id: A0A8P0NDG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9615:TTC4
gene id: 9615:TTC4
uniprot id: A0A8C0PPD0
uniprot id: A0A8I3NU85
names: Similarity
messages: Belongs to the TTC4 family.

9615:ABHD2
gene id: 9615:ABHD2
uniprot id: A0A8C0PRF3
uniprot id: A0A8I3MLA4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9615:ERG28
gene id: 9615:ERG28
uniprot id: A0A8C0SNU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:NME5
gene id: 9615:NME5
uniprot id: A0A8C0SGE5
uniprot id: A0A8I3P5U2
names: Similarity
messages: Belongs to the NDK family.

9615:CD79B
gene id: 9615:CD79B
uniprot id: A0A8P0SHE8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:PITX1
gene id: 9615:PITX1
uniprot id: A0A8C0MI34
uniprot id: A0A8I3NLR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9615:CCNB2
gene id: 9615:CCNB2
uniprot id: A0A8C0MTY9
uniprot id: A0A8I3NZG5
names: Similarity
messages: Belongs to the cyclin family.

9615:PITHD1
gene id: 9615:PITHD1
uniprot id: A0A8C0LUT7
uniprot id: A0A8I3RYI3
names: Similarity
messages: Belongs to the PITHD1 family.

9615:RFC2
gene id: 9615:RFC2
uniprot id: A0A8C0NC65
uniprot id: A0A8C0S4R7
uniprot id: A0A8I3MFP3
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9615:FGF9
gene id: 9615:FGF9
uniprot id: A0A8C0TNC4
uniprot id: J9P0B3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:COQ9
gene id: 9615:COQ9
uniprot id: A0A8I3RSQ3
uniprot id: A0A8P0TDT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

9615:POP7
gene id: 9615:POP7
uniprot id: A0A8C0SGI3
uniprot id: A0A8I3MDQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9615:PIGC
gene id: 9615:PIGC
uniprot id: A0A8C0SG29
uniprot id: A0A8I3NCB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9615:MTFP1
gene id: 9615:MTFP1
uniprot id: A0A8C0P4N2
uniprot id: A0A8I3P6R9
names: Similarity
messages: Belongs to the MTFP1 family.

9615:GNAL
gene id: 9615:GNAL
uniprot id: A0A8C0S278
uniprot id: A0A8I3RTU2
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9615:TSPYL4
gene id: 9615:TSPYL4
uniprot id: A0A8C0MBM6
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9615:TAF1
gene id: 9615:TAF1
uniprot id: A0A8C0S4Q1
uniprot id: A0A8P0SL75
uniprot id: A0A8P0T3E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF1 family.
messages: Nucleus

9615:NUP62
gene id: 9615:NUP62
uniprot id: A0A8C0M0Y9
uniprot id: A0A8I3P0U9
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

9615:FOXN3
gene id: 9615:FOXN3
uniprot id: A0A8C0LVT5
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
messages: Nucleus

9615:VAMP2
gene id: 9615:VAMP2
uniprot id: A0A8C0S0P5
uniprot id: A0A8I3Q453
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9615:NECTIN4
gene id: 9615:NECTIN4
uniprot id: A0A8C0SKL4
uniprot id: K4Q246
names: Similarity
messages: Belongs to the nectin family.

9615:TTC30B
gene id: 9615:TTC30B
uniprot id: A0A8C0P1S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9615:RNASE9
gene id: 9615:RNASE9
uniprot id: A0A8C0MP75
uniprot id: E2RG75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9615:ANGPT1
gene id: 9615:ANGPT1
uniprot id: Q60FC1
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity).
messages: Glycosylated.
messages: Secreted

9615:MAT1A
gene id: 9615:MAT1A
uniprot id: A0A8C0Z6S2
uniprot id: A0A8I3NL28
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9615:ERGIC2
gene id: 9615:ERGIC2
uniprot id: A0A8C0T1G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9615:CELF3
gene id: 9615:CELF3
uniprot id: A0A8C0YYR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

9615:MYH3
gene id: 9615:MYH3
uniprot id: Q076A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9615:UFM1
gene id: 9615:UFM1
uniprot id: A0A8I3PN19
uniprot id: A0A8I3S9Y2
uniprot id: A0A8P0NV41
uniprot id: A0A8P0PR83
names: Similarity
messages: Belongs to the UFM1 family.

9615:SEC11C
gene id: 9615:SEC11C
uniprot id: P13679
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:3511473, PubMed:8444896, PubMed:14559916). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
messages: Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SPCS2 and SPCS3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
messages: Endoplasmic reticulum membrane
messages: May undergo processing at the N-terminus.
messages: The C-terminal short (CTS) helix is essential for catalytic activity (By similarity). It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates (By similarity).

9615:MANBA
gene id: 9615:MANBA
uniprot id: A0A8C0TKG1
uniprot id: A0A8I3PSC3
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

9615:NLGN2
gene id: 9615:NLGN2
uniprot id: A0A8C0QEZ2
uniprot id: A0A8I3PDM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9615:OR6S1
gene id: 9615:OR6S1
uniprot id: A0A8C0S9J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CDA
gene id: 9615:CDA
uniprot id: A0A8C0MP51
uniprot id: A0A8I3MFS9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

9615:ABI3
gene id: 9615:ABI3
uniprot id: A0A8C0M279
uniprot id: A0A8I3NFI0
names: Similarity
messages: Belongs to the ABI family.

9615:SYT16
gene id: 9615:SYT16
uniprot id: A0A8C0PC82
uniprot id: A0A8I3S7K2
names: Similarity
messages: Belongs to the synaptotagmin family.

9615:POLR3D
gene id: 9615:POLR3D
uniprot id: A0A8C0NTC2
uniprot id: A0A8I3PPE4
names: Subcellular Location Annotation
messages: Nucleus

9615:CDC42SE1
gene id: 9615:CDC42SE1
uniprot id: A0A8C0SFP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9615:STAT4
gene id: 9615:STAT4
uniprot id: A0A8C0NL42
uniprot id: A0A8C0SQ64
uniprot id: A0A8I3PTH5
uniprot id: A0A8I3QBC0
uniprot id: A0A8P0T3Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9615:CYP4X1
gene id: 9615:CYP4X1
uniprot id: A0A8I3P954
uniprot id: A0A8P0N6X0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:H3-3B
gene id: 9615:H3-3B
uniprot id: A0A8C0LQ69
uniprot id: E2R6K5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:PTCD3
gene id: 9615:PTCD3
uniprot id: A0A8C0SXT4
uniprot id: A0A8I3RXL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9615:VKORC1
gene id: 9615:VKORC1
uniprot id: A0A8C0M7P9
uniprot id: A0A8I3NM38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:CCN1
gene id: 9615:CCN1
uniprot id: A0A8C0NHU0
uniprot id: A0A8I3S8V0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:VGLL2
gene id: 9615:VGLL2
uniprot id: A0A8C0NPV3
uniprot id: A0A8I3MYC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

9615:HMOX2
gene id: 9615:HMOX2
uniprot id: A0A8C0SLY3
uniprot id: A0A8I3MH42
names: Similarity
messages: Belongs to the heme oxygenase family.

9615:TRMU
gene id: 9615:TRMU
uniprot id: A0A8C0QQ09
uniprot id: A0A8I3N2T0
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

9615:A4GALT
gene id: 9615:A4GALT
uniprot id: A0A8I3NTR2
uniprot id: A0A8P0S6X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9615:MRPL34
gene id: 9615:MRPL34
uniprot id: A0A8C0P5N0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

9615:TNNT1
gene id: 9615:TNNT1
uniprot id: A0A8I3MJG9
uniprot id: A0A8P0N5P2
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9615:KIF20B
gene id: 9615:KIF20B
uniprot id: A0A8C0TZS9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:PARP6
gene id: 9615:PARP6
uniprot id: A0A8C0RM34
uniprot id: A0A8I3PHV5
names: Similarity
messages: Belongs to the ARTD/PARP family.

9615:TSEN54
gene id: 9615:TSEN54
uniprot id: A0A8C0RC07
uniprot id: A0A8I3PTG1
names: Similarity
messages: Belongs to the SEN54 family.

9615:SIRT3
gene id: 9615:SIRT3
uniprot id: A0A8P0NYF7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

9615:KCNMB3
gene id: 9615:KCNMB3
uniprot id: A0A8C0TA44
uniprot id: A0A8I3NSX0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9615:NR2C2
gene id: 9615:NR2C2
uniprot id: A0A8C0T345
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:KIT
gene id: 9615:KIT
uniprot id: O97799
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation. Phosphorylated tyrosine residues are important for interaction with specific binding partners (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3 catalytic subunit. Interacts (via phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC. Interacts with IL1RAP (independent of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).
messages: Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to determine which are directly phosphorylated by KIT under in vivo conditions.
messages: Present in an inactive conformation in the absence of bound ligand. KITLG/SCF binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Activity is down-regulated by PRKCA-mediated phosphorylation on serine residues (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity).
messages: Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation.

9615:TMEM183A
gene id: 9615:TMEM183A
uniprot id: A0A8C0M0Y1
uniprot id: A0A8I3RY51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

9615:CDK1
gene id: 9615:CDK1
uniprot id: A0A8C0PV66
uniprot id: A0A8I3N3V4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:OTULINL
gene id: 9615:OTULINL
uniprot id: A0A8C0T8J3
uniprot id: A0A8C0Z2L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9615:PURG
gene id: 9615:PURG
uniprot id: A0A8C0SRR8
uniprot id: A0A8I3S1Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9615:ISCA2
gene id: 9615:ISCA2
uniprot id: A0A8C0P2Z5
uniprot id: A0A8I3NJ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9615:IZUMO2
gene id: 9615:IZUMO2
uniprot id: A0A8C0LWQ8
uniprot id: A0A8I3P6N2
names: Similarity
messages: Belongs to the Izumo family.

9615:GLIPR1
gene id: 9615:GLIPR1
uniprot id: A0A8I3PMT8
uniprot id: A0A8P0N3R4
names: Similarity
messages: Belongs to the CRISP family.

9615:ELAVL4
gene id: 9615:ELAVL4
uniprot id: A0A8C0MJG3
uniprot id: A0A8I3PLG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9615:ARMCX1
gene id: 9615:ARMCX1
uniprot id: A0A8C0MNI4
uniprot id: A0A8I3NZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9615:SLC5A6
gene id: 9615:SLC5A6
uniprot id: A0A8C0S0C8
uniprot id: A0A8I3MY61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9615:USP30
gene id: 9615:USP30
uniprot id: A0A8C0TKP5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9615:POLE2
gene id: 9615:POLE2
uniprot id: A0A8C0QAJ6
uniprot id: A0A8I3MIQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

9615:OAS3
gene id: 9615:OAS3
uniprot id: Q2KKD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9615:BCL2L2
gene id: 9615:BCL2L2
uniprot id: Q45T69
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Bcl-2 family.
messages: Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
messages: Mitochondrion membrane
messages: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX (By similarity).
messages: The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2 (By similarity).
messages: The BH4 motif seems to be involved in the anti-apoptotic function.

9615:TMPRSS6
gene id: 9615:TMPRSS6
uniprot id: A0A8C0MPB1
uniprot id: A0A8I3RU13
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:LSM1
gene id: 9615:LSM1
uniprot id: A0A8C0S6Z1
uniprot id: A0A8I3NF08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9615:POLR3F
gene id: 9615:POLR3F
uniprot id: A0A8C0RSR8
uniprot id: A0A8I3SCD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9615:PARD3B
gene id: 9615:PARD3B
uniprot id: A0A8I3S0X4
uniprot id: A0A8P0PDP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

9615:TSHR
gene id: 9615:TSHR
uniprot id: P14763
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Glycosylated.
messages: Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production. Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
messages: Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation.

9615:IMMP1L
gene id: 9615:IMMP1L
uniprot id: A0A8C0TF76
uniprot id: A0A8I3QGP8
uniprot id: A0A8I3SBI5
uniprot id: A0A8P0N9T9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9615:SERPINA9
gene id: 9615:SERPINA9
uniprot id: A0A8C0Q110
names: Similarity
messages: Belongs to the serpin family.

9615:HPSE
gene id: 9615:HPSE
uniprot id: A0A8C0N1C5
uniprot id: A0A8I3P836
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9615:MMP7
gene id: 9615:MMP7
uniprot id: A0A8C0TCL1
uniprot id: A0A8I3MCQ8
uniprot id: F2YQ11
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9615:FAM163A
gene id: 9615:FAM163A
uniprot id: A0A8C0QB04
uniprot id: A0A8I3MXW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9615:SENP7
gene id: 9615:SENP7
uniprot id: A0A8I3S4I3
uniprot id: A0A8P0SRX0
names: Similarity
messages: Belongs to the peptidase C48 family.

9615:SLC2A2
gene id: 9615:SLC2A2
uniprot id: A0A8C0SDG1
uniprot id: A0A8I3PMW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9615:TLCD2
gene id: 9615:TLCD2
uniprot id: A0A8C0RWC8
uniprot id: A0A8I3NY16
names: Subcellular Location Annotation
messages: Membrane

9615:HM13
gene id: 9615:HM13
uniprot id: A0A8C0MQ52
uniprot id: A0A8I3S0I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9615:COX4I1
gene id: 9615:COX4I1
uniprot id: A0A8C0NS51
uniprot id: A0A8I3MW16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9615:GGTA1
gene id: 9615:GGTA1
uniprot id: A0A8C0MNE1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

9615:P2RX2
gene id: 9615:P2RX2
uniprot id: A0A8P0NZC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9615:PIK3CA
gene id: 9615:PIK3CA
uniprot id: A0A5F4C2B1
uniprot id: A0A8C0T7K1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9615:PRR5L
gene id: 9615:PRR5L
uniprot id: A0A8C0YY37
uniprot id: A0A8I3PJZ6
names: Similarity
messages: Belongs to the PROTOR family.

9615:ISG15
gene id: 9615:ISG15
uniprot id: A0A8I3P342
uniprot id: A0A8P0NKJ2
names: Subcellular Location Annotation
messages: cytosol

9615:NIM1K
gene id: 9615:NIM1K
uniprot id: A0A8C0S894
uniprot id: A0A8I3MIY1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:PRLR
gene id: 9615:PRLR
uniprot id: A0A8C0S6N3
uniprot id: A0A8I3MFS4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9615:XYLT1
gene id: 9615:XYLT1
uniprot id: Q5QQ56
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal maturation of chondrocytes during bone development, normal onset of ossification and normal embryonic and postnatal skeleton development, especially of the long bones.
messages: Contains 7 disulfide bonds.
messages: Golgi apparatus membrane
messages: Monomer.
messages: N-glycosylated.

9615:AMN
gene id: 9615:AMN
uniprot id: Q6UKI2
uniprot id: W0GED9
names: Disease Annotation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A soluble form arises by proteolytic removal of the membrane anchor.
messages: Apical cell membrane
messages: Cell membrane
messages: Defects in AMN are a cause of a canine form of megaloblastic anemia 1 (MGA1).
messages: Detected in kidney (at protein level). Detected in kidney and ileum.
messages: Endosome membrane
messages: Interacts (via extracellular region) with CUBN/cubilin (PubMed:15845892). This gives rise to a huge complex containing one AMN chain and three CUBN chains (By similarity).
messages: Membrane
messages: Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface. The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12. Required for normal CUBN-mediated protein transport in the kidney.
messages: N-glycosylated.
messages: Secreted
messages: The complex formed by AMN and CUBN is composed of a 400 Angstrom long stem and a globular crown region. The stem region is probably formed by AMN and the CUBN N-terminal region, including the EGF-like domains. The crown is probably formed by the CUBN CUB domains.
messages: The role of Amn in embryonic development seems to be species specific. In mice, null mutations lead to embryonic lethality. Canine mutations give rise to much milder symptoms.
messages: coated pit

9615:CDC42BPA
gene id: 9615:CDC42BPA
uniprot id: A0A8C0MFS8
uniprot id: A0A8C0MH00
uniprot id: A0A8C0MIP6
uniprot id: A0A8C0MJ32
uniprot id: A0A8C0MJS7
uniprot id: A0A8C0MK07
uniprot id: A0A8C0RDY8
uniprot id: A0A8C0S3L0
uniprot id: A0A8C0YUF4
uniprot id: A0A8I3MWV0
uniprot id: A0A8I3NHR3
uniprot id: A0A8P0NHL8
uniprot id: A0A8P0P9T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9615:PRSS23
gene id: 9615:PRSS23
uniprot id: A0A8P0TTA6
names: Similarity
messages: Belongs to the peptidase S1B family.

9615:EIF4EBP2
gene id: 9615:EIF4EBP2
uniprot id: A0A8C0N6R1
uniprot id: A0A8I3MX40
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9615:CMTM2
gene id: 9615:CMTM2
uniprot id: A0A8C0N444
uniprot id: A0A8I3NGD1
names: Subcellular Location Annotation
messages: Membrane

9615:RPL22
gene id: 9615:RPL22
uniprot id: A0A8C0MDD5
uniprot id: A0A8I3PER7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9615:GPI
gene id: 9615:GPI
uniprot id: A0A8C0M159
uniprot id: A0A8I3RTC4
names: Similarity
messages: Belongs to the GPI family.

9615:P4HA2
gene id: 9615:P4HA2
uniprot id: A0A8C0N641
uniprot id: A0A8C0N6E8
uniprot id: A0A8I3NFI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9615:CCL4
gene id: 9615:CCL4
uniprot id: Q68AZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Homodimer. Interacts with CCR5 (By similarity).
messages: Monokine with inflammatory and chemokinetic properties.
messages: Secreted

9615:STRN3
gene id: 9615:STRN3
uniprot id: A0A8C0N6A8
uniprot id: A0A8C0SAQ0
uniprot id: A0A8C0SBT1
uniprot id: A0A8I3N628
uniprot id: A0A8I3NGI8
uniprot id: A0A8P0NEN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9615:THG1L
gene id: 9615:THG1L
uniprot id: A0A8C0N021
uniprot id: A0A8I3MZC1
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

9615:NRXN2
gene id: 9615:NRXN2
uniprot id: A0A8P0SWQ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:AK6
gene id: 9615:AK6
uniprot id: A0A8C0RXH8
uniprot id: A0A8I3NND6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9615:SDF4
gene id: 9615:SDF4
uniprot id: A0A8I3PU05
uniprot id: A0A8P0NMK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

9615:EFEMP1
gene id: 9615:EFEMP1
uniprot id: A0A8C0P6Z0
uniprot id: A0A8I3NN55
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:MARS1
gene id: 9615:MARS1
uniprot id: A0A8C0MJ30
uniprot id: A0A8I3NFF8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:LHX4
gene id: 9615:LHX4
uniprot id: A0A8C0RBX9
uniprot id: A0A8I3MPI3
names: Subcellular Location Annotation
messages: Nucleus

9615:CENPU
gene id: 9615:CENPU
uniprot id: A0A8C0SI06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-U/AME1 family.
messages: Nucleus

9615:NCSTN
gene id: 9615:NCSTN
uniprot id: M1VPL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9615:AIF1L
gene id: 9615:AIF1L
uniprot id: A0A8I3PCA0
uniprot id: A0A8P0TUJ5
names: Subcellular Location Annotation
messages: ruffle membrane

9615:RDH12
gene id: 9615:RDH12
uniprot id: A0A8C0SDK6
uniprot id: A0A8I3MRK7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:CAPZA1
gene id: 9615:CAPZA1
uniprot id: A0A8C0SIZ0
uniprot id: A0A8I3NF50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9615:IREB2
gene id: 9615:IREB2
uniprot id: A0A8C0MSG6
uniprot id: A0A8I3NZI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Cytoplasm

9615:OTUD7B
gene id: 9615:OTUD7B
uniprot id: A0A8P0SGI8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:HSF4
gene id: 9615:HSF4
uniprot id: Q1HGE8
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HSF family.
messages: Constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by phosphorylation on Ser-299 (By similarity).
messages: Defects in HSF4 are a cause of forms of hereditary cataract (HC) in dogs. Mutations in HSF4 seem to be causing a recessive form of cataract in Staffordshire Bull terriers and Boston terriers and a dominant cataract in Australian shepherds.
messages: Heat-shock transcription factor that specifically binds heat shock promoter elements (HSE) (By similarity). Required for denucleation and organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (By similarity). In this process, may regulate denucleation of lens fiber cells in part by activating DNASE2B transcription (By similarity). May be involved in DNA repair through the transcriptional regulation of RAD51 (By similarity). May up-regulate p53/TP53 protein in eye lens fiber cells, possibly through protein stabilization (By similarity). In the eye lens, controls the expression of alpha-crystallin B chain/CRYAB and consequently may be involved in the regulation of lysosomal acidification (By similarity).
messages: Homotrimer. Exhibits constitutive DNA binding and forms trimers even in the absence of stress. Interacts with ALKBH4, DUSP26, MAPK1, MAPK2, MAPK8 and MAP kinase p38.
messages: Nucleus
messages: Phosphorylated mainly on serine residues. Phosphorylation on Ser-299 promotes sumoylation on Lys-294 (By similarity).

9615:GALNT17
gene id: 9615:GALNT17
uniprot id: A0A8C0QLX7
uniprot id: A0A8I3MHX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:ARL4D
gene id: 9615:ARL4D
uniprot id: A0A8C0T404
uniprot id: A0A8I3NH73
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9615:GPRC5D
gene id: 9615:GPRC5D
uniprot id: A0A8I3PNT9
uniprot id: A0A8P0TBC6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:LOC482755
gene id: 9615:LOC482755
uniprot id: A0A8C0Q7N6
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

9615:DEFB118
gene id: 9615:DEFB118
uniprot id: A0A8P0NMN4
uniprot id: Q30KT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:ASB17
gene id: 9615:ASB17
uniprot id: A0A8C0PL69
uniprot id: A0A8I3MWR8
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9615:NOP10
gene id: 9615:NOP10
uniprot id: A0A8C0TN69
names: Similarity
messages: Belongs to the NOP10 family.

9615:ALDH1L2
gene id: 9615:ALDH1L2
uniprot id: A0A8C0YT63
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9615:ABCA9
gene id: 9615:ABCA9
uniprot id: A0A8I3Q0K5
uniprot id: A0A8P0SRJ8
names: Subcellular Location Annotation
messages: Membrane

9615:NOP58
gene id: 9615:NOP58
uniprot id: A0A8C0RNY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9615:RPS6
gene id: 9615:RPS6
uniprot id: A0A8C0Z2B3
uniprot id: A0A8I3NUU7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

9615:VPS25
gene id: 9615:VPS25
uniprot id: A0A8C0LUY1
uniprot id: A0A8I3NID4
names: Similarity
messages: Belongs to the VPS25 family.

9615:LOC119863880
gene id: 9615:LOC119863880
uniprot id: A0A8C0SQW3
uniprot id: A0A8I3MWA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:TMEM120B
gene id: 9615:TMEM120B
uniprot id: A0A8C0SWS8
uniprot id: A0A8I3PPD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9615:ALDH18A1
gene id: 9615:ALDH18A1
uniprot id: A0A8C0Z5M9
uniprot id: A0A8I3PPU5
uniprot id: A0A8P0NAS4
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

9615:ARPC5
gene id: 9615:ARPC5
uniprot id: A0A8C0LYM6
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9615:SLC5A3
gene id: 9615:SLC5A3
uniprot id: P31637
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (PubMed:7537337, PubMed:1372904). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (By similarity). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity). Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (By similarity). Has very low affinity for sugars such as L-fucose and L-xylose, with an affinity about three orders of magnitude lower than myo-inositol (PubMed:7537337).
messages: Inhibited by phlorizin and phloretin.
messages: Interacts with KCNQ2 (via the pore module) (By similarity). Interacts with KCNQ1; this interaction is direct (By similarity). Forms coregulatory complexes with ion channels KCNQ2-KCNQ3 and KCNQ1-KCNE2 (By similarity).
messages: Kidney cortex and medulla.
messages: Up-regulated in response to hypertonicity.

9615:PADI4
gene id: 9615:PADI4
uniprot id: A0A8I3MWP1
uniprot id: A0A8P0SK18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9615:NOB1
gene id: 9615:NOB1
uniprot id: A0A8C0T7F4
uniprot id: A0A8I3N1B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

9615:FGG
gene id: 9615:FGG
uniprot id: A0A8C0SFJ2
uniprot id: A0A8I3N8Y1
uniprot id: A0A8I3NPH9
uniprot id: A0A8P0TNR1
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9615:GOSR2
gene id: 9615:GOSR2
uniprot id: A0A8C0MQ68
uniprot id: A0A8C0SD09
uniprot id: A0A8I3PQR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9615:UTP14A
gene id: 9615:UTP14A
uniprot id: A0A8C0TBV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

9615:SFXN2
gene id: 9615:SFXN2
uniprot id: A0A8C0PC13
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9615:ZNF496
gene id: 9615:ZNF496
uniprot id: A0A8C0SRJ0
names: Subcellular Location Annotation
messages: Nucleus

9615:ADAMTS13
gene id: 9615:ADAMTS13
uniprot id: F7J124
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:PPAT
gene id: 9615:PPAT
uniprot id: A0A8C0P4I5
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9615:VPS33A
gene id: 9615:VPS33A
uniprot id: A0A8C0TSZ8
uniprot id: A0A8I3PF57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9615:ADGRG7
gene id: 9615:ADGRG7
uniprot id: A0A8C0Z592
names: Subcellular Location Annotation
messages: Membrane

9615:STK3
gene id: 9615:STK3
uniprot id: A0A8C0SHB4
uniprot id: A0A8I3PTK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9615:TH
gene id: 9615:TH
uniprot id: Q76IQ3
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity).
messages: Cytoplasm
messages: Homotetramer (By similarity). Interacts (when phosphorylated at Ser-19) with YWHAG; one YWHAG dimer bounds to one TH tetramer this interaction may influence the phosphorylation and dephosphorylation of other sites (By similarity).
messages: Inhibited in feedback fashion by the catecholamine neurotransmitters, especially by dopamine in competition with tetrahydrobiopterin. Phosphorylation of several Ser/Thr residues in the N-terminus regulates the catalytic activity. Ser-31 and Ser-40 are readily phosphorylated to activate the catalytic activity. A Cysteine modification induced by N-ethylmaleimide (NEM), inhibits tyrosine 3-monooxygenase activity through the modification of the Cys-174.
messages: Nucleus
messages: Phosphorylated on Ser-19, Ser-31 and Ser-40 by several protein kinases with different site specificities. Phosphorylation at Ser-31 and Ser-40 leads to an increase of TH activity. Phosphorylation at Ser-40 activates the enzyme and also counteracts the feedback inhibition of TH by catecholamines (By similarity). Phosphorylation of Ser-19 and Ser-31 triggers the proteasomal degradation of TH through the ubiquitin-proteasome pathway (By similarity). Phosphorylation at Ser-31 facilitates transport of TH from the soma to the nerve terminals via the microtubule network (By similarity). Phosphorylation at Ser-19 induces the high-affinity binding to the 14-3-3 protein YWHAG; this interaction may influence the phosphorylation and dephosphorylation of other sites (By similarity). Ser-19 increases the phosphorylation at Ser-40 in a hierarchical manner, leading to increased activity (By similarity).
messages: axon
messages: perinuclear region
messages: synaptic vesicle

9615:STK32B
gene id: 9615:STK32B
uniprot id: A0A8C0M072
uniprot id: A0A8I3MP15
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:LOC102156556
gene id: 9615:LOC102156556
uniprot id: A0A8C0RVL5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9615:CLTC
gene id: 9615:CLTC
uniprot id: A0A8C0MFZ6
uniprot id: A0A8I3PQE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9615:LOC607552
gene id: 9615:LOC607552
uniprot id: A0A8C0NXP9
names: Subcellular Location Annotation
messages: Membrane

9615:SUSD6
gene id: 9615:SUSD6
uniprot id: A0A8C0NJZ1
uniprot id: A0A8I3RRV5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CTBP2
gene id: 9615:CTBP2
uniprot id: A0A8C0TB85
uniprot id: A0A8I3S9U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9615:OR13F1B
gene id: 9615:OR13F1B
uniprot id: A0A8C0P0J7
uniprot id: A0A8I3N2K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SMC2
gene id: 9615:SMC2
uniprot id: A0A8P0S8Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Chromosome
messages: Nucleus

9615:ANP32A
gene id: 9615:ANP32A
uniprot id: A0A8I3S455
uniprot id: A0A8P0P429
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9615:DLC1
gene id: 9615:DLC1
uniprot id: A0A8P0PPB6
uniprot id: B9VTT2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (By similarity). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (By similarity).
messages: Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration. Interacts with tensin TNS1 (via N-terminus); the interaction is decreased by phosphorylation of TNS1. Interacts with TNS3 and PTEN; in resting cells, interacts with TNS3 (via C2 tensin-type domain) but, following growth factor stimulation, TNS3 and PTEN are phosphorylated which leads to weakened interaction with TNS3 and enhanced interaction with PTEN. Interacts (via C-terminus) with tensin TNS4 (via SH2 domain); the interaction is independent of tyrosine phosphorylation of DLC1.
messages: Membrane
messages: The SAM domain mediates interaction with EF1A1, and functions as an autoinhibitory regulator of RhoGAP Activity.
messages: The polybasic cluster is required for activation and mediates binding to phosphatidylinositol-4,5-bisphosphate (PI(4,5)P(2)) containing membranes.
messages: focal adhesion

9615:SFMBT2
gene id: 9615:SFMBT2
uniprot id: A0A8I3MIJ6
uniprot id: A0A8P0SAN9
names: Subcellular Location Annotation
messages: Nucleus

9615:AADAC
gene id: 9615:AADAC
uniprot id: A0A8C0SHW2
uniprot id: A0A8I3PXU4
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9615:GLYAT
gene id: 9615:GLYAT
uniprot id: A0A8C0NWV5
uniprot id: A0A8I3PBY9
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9615:HABP2
gene id: 9615:HABP2
uniprot id: A0A8P0NCZ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:GANAB
gene id: 9615:GANAB
uniprot id: A0A8C0MBF0
uniprot id: A0A8C0TAI1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9615:LAP3
gene id: 9615:LAP3
uniprot id: A0A8C0M6L4
uniprot id: A0A8I3MBN3
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9615:GJA9
gene id: 9615:GJA9
uniprot id: A0A654IFD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:OLFM3
gene id: 9615:OLFM3
uniprot id: A0A8C0P411
uniprot id: A0A8C0PVH9
uniprot id: A0A8I3NB44
uniprot id: A0A8I3NKF9
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9615:ADD3
gene id: 9615:ADD3
uniprot id: A0A8C0T4V3
uniprot id: A0A8I3PX64
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9615:LOC100685822
gene id: 9615:LOC100685822
uniprot id: A0A8P0NR06
names: Subcellular Location Annotation
messages: Nucleus

9615:POP5
gene id: 9615:POP5
uniprot id: A0A8C0T896
uniprot id: A0A8I3QWJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9615:MLN
gene id: 9615:MLN
uniprot id: A0A8C0S8T0
uniprot id: A0A8I3PYW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
messages: Secreted

9615:IRF2
gene id: 9615:IRF2
uniprot id: A0A8C0NH22
uniprot id: A0A8I3NTT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9615:SLC25A16
gene id: 9615:SLC25A16
uniprot id: A0A8C0Q1M6
uniprot id: A0A8I3MF97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:LTF
gene id: 9615:LTF
uniprot id: A0A8I3NMR3
uniprot id: A0A8P0SIR0
names: Similarity
messages: Belongs to the transferrin family.

9615:PSMD2
gene id: 9615:PSMD2
uniprot id: A0A8C0TS00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9615:THNSL1
gene id: 9615:THNSL1
uniprot id: A0A8C0PXM0
uniprot id: A0A8I3MP47
names: Similarity
messages: Belongs to the threonine synthase family.

9615:TINAGL1
gene id: 9615:TINAGL1
uniprot id: A0A8C0P6B8
uniprot id: A0A8I3RUE7
names: Similarity
messages: Belongs to the peptidase C1 family.

9615:FNTB
gene id: 9615:FNTB
uniprot id: A0A8C0QQC1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
messages: Heterodimer of FNTA and FNTB.

9615:CRYBB1
gene id: 9615:CRYBB1
uniprot id: A0A8C0TU15
uniprot id: E2R5F6
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9615:DCLRE1B
gene id: 9615:DCLRE1B
uniprot id: A0A8P0PHX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9615:HSPA4L
gene id: 9615:HSPA4L
uniprot id: A0A8C0MP67
uniprot id: A0A8I3P2E0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9615:MED11
gene id: 9615:MED11
uniprot id: A0A8C0MN13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:PNPLA7
gene id: 9615:PNPLA7
uniprot id: A0A8P0SNF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:CAPZA3
gene id: 9615:CAPZA3
uniprot id: A0A8C0PE89
uniprot id: A0A8I3PDJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9615:RAB3GAP2
gene id: 9615:RAB3GAP2
uniprot id: A0A8C0PAL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

9615:APOL5
gene id: 9615:APOL5
uniprot id: A0A8I3N6X6
uniprot id: A0A8P0NLH2
names: Similarity
messages: Belongs to the apolipoprotein L family.

9615:OR7A65
gene id: 9615:OR7A65
uniprot id: A0A8C0PGQ6
uniprot id: A0A8I3P6T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:AKR1C3
gene id: 9615:AKR1C3
uniprot id: A0A8C0LYD8
uniprot id: Q5FYA7
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9615:IP6K3
gene id: 9615:IP6K3
uniprot id: A0A8C0M6W6
uniprot id: A0A8I3PS77
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9615:SFMBT1
gene id: 9615:SFMBT1
uniprot id: A0A8I3Q269
uniprot id: A0A8P0NB42
names: Subcellular Location Annotation
messages: Nucleus

9615:PDE7B
gene id: 9615:PDE7B
uniprot id: A0A8P0N3I7
uniprot id: A0A8P0PG76
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:MRPS21
gene id: 9615:MRPS21
uniprot id: A0A8C0MI93
uniprot id: A0A8I3RZJ6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9615:GRK7
gene id: 9615:GRK7
uniprot id: A0A8C0M4L1
uniprot id: A0A8I3PWQ2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9615:MBOAT7
gene id: 9615:MBOAT7
uniprot id: A0A8C0LWR4
uniprot id: A0A8C0RAI2
uniprot id: A0A8I3MRI3
names: Subcellular Location Annotation
messages: Membrane

9615:ACTR6
gene id: 9615:ACTR6
uniprot id: A0A8C0RM92
uniprot id: A0A8I3MYA7
names: Similarity
messages: Belongs to the actin family.

9615:CSNK2B
gene id: 9615:CSNK2B
uniprot id: A0A8C0RCK5
uniprot id: A0A8I3NFB2
uniprot id: A0A8I3NIN1
uniprot id: A0A8P0PPN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

9615:VAMP4
gene id: 9615:VAMP4
uniprot id: A0A8C0LYJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9615:CAPN5
gene id: 9615:CAPN5
uniprot id: A0A8C0P1B0
names: Similarity
messages: Belongs to the peptidase C2 family.

9615:GALNT2
gene id: 9615:GALNT2
uniprot id: A0A8I3MHQ8
uniprot id: A0A8P0NU19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:NIPA1
gene id: 9615:NIPA1
uniprot id: A0A8C0RF28
uniprot id: A0A8I3NUF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9615:GDA
gene id: 9615:GDA
uniprot id: A0A8C0PUH1
uniprot id: A0A8I3RQL8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9615:EFNA3
gene id: 9615:EFNA3
uniprot id: A0A8C0PDI3
uniprot id: A0A8I3NEL5
uniprot id: A0A8I3NG87
uniprot id: A0A8P0TJD7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:DCT
gene id: 9615:DCT
uniprot id: L0N6C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9615:OR52J8
gene id: 9615:OR52J8
uniprot id: A0A8C0TLA3
uniprot id: A0A8I3NYI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:PDS5A
gene id: 9615:PDS5A
uniprot id: A0A8C0Z1E0
uniprot id: A0A8I3MSX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDS5 family.
messages: Nucleus

9615:ADGRF5
gene id: 9615:ADGRF5
uniprot id: A0A8C0YY14
uniprot id: A0A8C0YY19
uniprot id: A0A8I3S016
uniprot id: A0A8P0N555
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Membrane

9615:AP3B1
gene id: 9615:AP3B1
uniprot id: Q7YRF1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP-3 associates with the BLOC-1 complex (By similarity). Interacts with KIF3A; interaction is direct; interaction is impaired by pyrophosphorylation of AP3B1 (By similarity).
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus
messages: Phosphorylated on serine residues.
messages: Pyrophosphorylation by 5-diphosphoinositol pentakisphosphate (5-IP7) impairs interaction with KIF3A. Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9615:OR13L2
gene id: 9615:OR13L2
uniprot id: A0A8P0SP95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:LZTFL1
gene id: 9615:LZTFL1
uniprot id: A0A8C0T2W8
uniprot id: A0A8I3RX08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9615:RNFT2
gene id: 9615:RNFT2
uniprot id: A0A8I3PSJ1
names: Subcellular Location Annotation
messages: Membrane

9615:HDHD2
gene id: 9615:HDHD2
uniprot id: A0A8C0NR62
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9615:PARK7
gene id: 9615:PARK7
uniprot id: A0A8C0MN34
uniprot id: A0A8I3Q111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9615:TCEA1
gene id: 9615:TCEA1
uniprot id: A0A8C0TX61
uniprot id: A0A8I3Q821
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9615:TAS1R1
gene id: 9615:TAS1R1
uniprot id: A0A8C0MNP5
uniprot id: A0A8I3Q7L4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:ZNF18
gene id: 9615:ZNF18
uniprot id: A0A8C0T5L1
uniprot id: A0A8I3N5H1
names: Subcellular Location Annotation
messages: Nucleus

9615:ABO
gene id: 9615:ABO
uniprot id: A0A8C0PMD0
uniprot id: F1PEJ9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

9615:NOP56
gene id: 9615:NOP56
uniprot id: A0A8C0MD96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9615:CYP2F1
gene id: 9615:CYP2F1
uniprot id: A0A8C0M3A7
uniprot id: A0A8I3MMW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane
messages: Microsome membrane

9615:PTEN
gene id: 9615:PTEN
uniprot id: P60483
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. Tumor suppressor, the lipid phosphatase activity is critical for its tumor suppressor function (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (By similarity). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (By similarity). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (By similarity). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory h…
messages: Belongs to the PTEN phosphatase protein family.
messages: Constitutively phosphorylated by CK2 under normal conditions. Phosphorylation results in an inhibited activity towards PIP3. Phosphorylation can both inhibit or promote PDZ-binding. Phosphorylation at Tyr-336 by FRK/PTK5 protects this protein from ubiquitin-mediated degradation probably by inhibiting its binding to NEDD4 (By similarity). Phosphorylation by PLK3 promotes its stability and prevents its degradation by the proteasome. Phosphorylation by ROCK1 is essential for its stability and activity (By similarity). Phosphorylated on Thr-319 and Thr-321 in the C2-type tensin domain following EGF stimulation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 (By similarity).
messages: Cytoplasm
messages: ISGylated. ISGylation promotes PTEN degradation.
messages: Monomer. The unphosphorylated form interacts with the second PDZ domain of MAGI2 (By similarity). Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor with DLG5; interaction with MAGI2 increases protein stability (By similarity). Interacts with NEDD4 (By similarity). Interacts with NDFIP1 and NDFIP2; in the presence of NEDD4 or ITCH, this interaction promotes PTEN ubiquitination (By similarity). Interacts (via C2 domain) with FRK (By similarity). Interacts with USP7; the interaction is direct (By similarity). Interacts with ROCK1. Interacts with XIAP/BIRC4 (By similarity). Interacts with STK11; the interaction phosphorylates PTEN (By similarity). Interacts with PPP1R16B (By similarity). Interacts with NOP53; regulates PTEN phosphorylation and increases its stability (By similarity). Interacts (via PDZ domain-binding motif) with DLG4; the interaction is induced by NMDA and is required for PTEN location at postsynaptic density (By similarity). Interacts with the regulatory p85 subunit of the PI3K kinase complex and with Rho GTPase-activating protein DLC1; in resting cells, interacts (via C2 tensin-type domain) with p85 but, following growth factor stimulation, PTEN is phosphorylated which leads to weakened interaction with p85 and enhanced interaction (via C2 tensin-type domain) with DLC1 while p85 interaction with TNS3 increases (By similarity).
messages: Monoubiquitinated; monoubiquitination is increased in presence of retinoic acid. Deubiquitinated by USP7; leading to its nuclear exclusion. Monoubiquitination of one of either Lys-13 and Lys-289 amino acid is sufficient to modulate PTEN compartmentalization (By similarity). Ubiquitinated by XIAP/BIRC4 (By similarity).
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation.
messages: dendritic spine

9615:MORF4L2
gene id: 9615:MORF4L2
uniprot id: A0A8C0N2B4
uniprot id: A0A8I3PF91
names: Subcellular Location Annotation
messages: Nucleus

9615:ALG8
gene id: 9615:ALG8
uniprot id: A0A8C0YX99
uniprot id: A0A8I3N360
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:INSIG1
gene id: 9615:INSIG1
uniprot id: A0A8C0RNL3
uniprot id: A0A8I3NKC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9615:RBM47
gene id: 9615:RBM47
uniprot id: Q9XSR3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM RBM47 family.
messages: Cytoplasm
messages: Homodimer. Interacts with A1CF. Interacts with APOBEC1; form an mRNA editing complex.
messages: Nucleus
messages: Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing. Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules. Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10. Also involved in the alternative splicing of several genes including TJP1. Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs (By similarity). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity).
messages: The RRM domains are required for mRNA stabilization.

9615:TTC3
gene id: 9615:TTC3
uniprot id: A0A8C0T874
uniprot id: A0A8I3S6L0
names: Subcellular Location Annotation
messages: Cytoplasm

9615:BBOX1
gene id: 9615:BBOX1
uniprot id: A0A8P0NC71
names: Function
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

9615:EFNB2
gene id: 9615:EFNB2
uniprot id: A0A8C0M8W9
uniprot id: B0LDS6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:SLC35C2
gene id: 9615:SLC35C2
uniprot id: A0A8C0QD29
uniprot id: A0A8I3NX77
names: Subcellular Location Annotation
messages: Membrane

9615:EPYC
gene id: 9615:EPYC
uniprot id: A0A8C0SX28
uniprot id: A0A8I3S169
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9615:ESRRB
gene id: 9615:ESRRB
uniprot id: A0A8C0N8Z3
uniprot id: A0A8I3MU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9615:CHRM1
gene id: 9615:CHRM1
uniprot id: A0A8C0MJA7
uniprot id: A0A8I3RVA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9615:KATNAL1
gene id: 9615:KATNAL1
uniprot id: A0A8C0SX29
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9615:PFDN6
gene id: 9615:PFDN6
uniprot id: Q5TJE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits (By similarity). Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92 (By similarity).

9615:DNASE1
gene id: 9615:DNASE1
uniprot id: Q767J3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DNase I family.
messages: Divalent metal cations. Prefers Ca(2+) or Mg(2+).
messages: Highest expression in pancreas.
messages: Nucleus envelope
messages: Secreted
messages: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:14688237). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:14688237). Binds specifically to G-actin and blocks actin polymerization (PubMed:14688237). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
messages: Zymogen granule

9615:GPR31
gene id: 9615:GPR31
uniprot id: A0A8C0PS74
uniprot id: A0A8I3MVK0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:ABHD1
gene id: 9615:ABHD1
uniprot id: A0A8I3MTT4
uniprot id: A0A8P0NLZ2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9615:MADD
gene id: 9615:MADD
uniprot id: A0A8C0PII1
uniprot id: A0A8C0PK04
uniprot id: A0A8I3PFN7
uniprot id: A0A8I3PLS9
uniprot id: A0A8I3PRU0
uniprot id: A0A8I3S3R5
uniprot id: A0A8P0P694
uniprot id: A0A8P0SDS7
uniprot id: A0A8P0TD02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9615:MAGEB10
gene id: 9615:MAGEB10
uniprot id: Q9TTY4
names: Tissue Specificity
messages: Detected only in the melanoma and testis and not in other normal tissues.

9615:AZIN1
gene id: 9615:AZIN1
uniprot id: A0A8C0MTP9
uniprot id: A0A8I3MWX9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9615:MMD
gene id: 9615:MMD
uniprot id: A0A8C0N6I5
uniprot id: A0A8I3P8K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9615:SERBP1
gene id: 9615:SERBP1
uniprot id: A0A8C0RZ75
uniprot id: A0A8I3QC63
names: Similarity
messages: Belongs to the SERBP1-HABP4 family.

9615:MMP26
gene id: 9615:MMP26
uniprot id: A0A8C0P0M1
uniprot id: A0A8I3PG50
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9615:SMIM12
gene id: 9615:SMIM12
uniprot id: E2R5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM12 family.
messages: Membrane

9615:GRIK3
gene id: 9615:GRIK3
uniprot id: A0A8C0RP23
uniprot id: A0A8I3QTN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9615:CCDC124
gene id: 9615:CCDC124
uniprot id: A0A8C0S442
uniprot id: A0A8I3PLP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC124 family.
messages: Midbody

9615:STX4
gene id: 9615:STX4
uniprot id: A0A8I3NNE2
uniprot id: A0A8P0NI52
names: Similarity
messages: Belongs to the syntaxin family.

9615:UFC1
gene id: 9615:UFC1
uniprot id: A0A8C0P6D8
uniprot id: A0A8I3Q438
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9615:CSF3R
gene id: 9615:CSF3R
uniprot id: A0A8C0NTT8
uniprot id: A0A8I3Q7L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9615:EPN1
gene id: 9615:EPN1
uniprot id: A0A8C0QFH2
uniprot id: A0A8I3MFJ4
uniprot id: A0A8P0PDX2
names: Similarity
messages: Belongs to the epsin family.

9615:CHST10
gene id: 9615:CHST10
uniprot id: A0A8C0NYD9
uniprot id: A0A8I3P218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:NT5C2
gene id: 9615:NT5C2
uniprot id: A0A8C0PN05
uniprot id: A0A8C0Z5X2
uniprot id: A0A8I3PWT8
uniprot id: A0A8I3QC03
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9615:RNASE4
gene id: 9615:RNASE4
uniprot id: W0UVG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9615:S100A10
gene id: 9615:S100A10
uniprot id: A0A8C0MWD1
uniprot id: E2RGM0
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

9615:C7H18orf21
gene id: 9615:C7H18orf21
uniprot id: A0A8P0NXZ9
names: Similarity
messages: Belongs to the UPF0711 family.

9615:SMPD3
gene id: 9615:SMPD3
uniprot id: A0A8C0NF07
uniprot id: A0A8I3NK36
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9615:MED27
gene id: 9615:MED27
uniprot id: A0A8C0NL17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:CNN1
gene id: 9615:CNN1
uniprot id: A0A8C0SQN1
uniprot id: A0A8I3S0B8
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9615:RPL11
gene id: 9615:RPL11
uniprot id: A0A8C0PQT2
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

9615:FAM114A2
gene id: 9615:FAM114A2
uniprot id: A0A8C0MIK1
uniprot id: A0A8I3RSF5
names: Similarity
messages: Belongs to the FAM114 family.

9615:LOC477699
gene id: 9615:LOC477699
uniprot id: A0A8C0PDB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9615:ENPP1
gene id: 9615:ENPP1
uniprot id: A0A8C0PJE1
uniprot id: A0A8I3RQK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9615:CER1
gene id: 9615:CER1
uniprot id: A0A8I3NHH0
uniprot id: A0A8P0S7R2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:YWHAE
gene id: 9615:YWHAE
uniprot id: A0A8C0PTA0
uniprot id: A0A8I3NMG3
names: Similarity
messages: Belongs to the 14-3-3 family.

9615:MAB21L1
gene id: 9615:MAB21L1
uniprot id: A0A8C0SSE1
uniprot id: A0A8I3S718
names: Similarity
messages: Belongs to the mab-21 family.

9615:DIPK2A
gene id: 9615:DIPK2A
uniprot id: A0A8C0MR46
uniprot id: A0A8I3P6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9615:MED26
gene id: 9615:MED26
uniprot id: A0A8C0P8K6
uniprot id: A0A8I3Q1Y6
uniprot id: A0A8I3QW57
uniprot id: A0A8P0T3G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 26 family.
messages: Nucleus

9615:RPS12
gene id: 9615:RPS12
uniprot id: A0A8C0SK69
uniprot id: A0A8I3RTT6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9615:PPT1
gene id: 9615:PPT1
uniprot id: Q5JZR0
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9615:NOC2L
gene id: 9615:NOC2L
uniprot id: A0A8C0RVQ9
names: Similarity
messages: Belongs to the NOC2 family.

9615:EFNA4
gene id: 9615:EFNA4
uniprot id: A0A8C0PRQ5
uniprot id: A0A8I3NQ24
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:HEXA
gene id: 9615:HEXA
uniprot id: A0A8C0SV52
uniprot id: A0A8I3PNW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9615:SGTA
gene id: 9615:SGTA
uniprot id: A0A8C0MQZ8
uniprot id: F6XMP7
names: Similarity
messages: Belongs to the SGT family.

9615:INSIG2
gene id: 9615:INSIG2
uniprot id: A0A8C0NZL6
uniprot id: A0A8I3MQT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9615:GABARAPL1
gene id: 9615:GABARAPL1
uniprot id: A0A8C0NRR5
uniprot id: A0A8I3PYF3
names: Similarity
messages: Belongs to the ATG8 family.

9615:KIF2A
gene id: 9615:KIF2A
uniprot id: A0A8C0Q031
uniprot id: A0A8C0RW90
uniprot id: A0A8I3MZX0
uniprot id: A0A8I3NL14
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:SPON1
gene id: 9615:SPON1
uniprot id: A0A8C0PL07
uniprot id: A0A8I3PBE9
names: Subcellular Location Annotation
messages: extracellular matrix

9615:SPAM1
gene id: 9615:SPAM1
uniprot id: A0A8C0S4J6
uniprot id: A0A8I3MQH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9615:EEF1A1
gene id: 9615:EEF1A1
uniprot id: A0A8C0NJT4
uniprot id: F2Z4P4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9615:MFSD6L
gene id: 9615:MFSD6L
uniprot id: A0A8C0N9Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9615:CHPT1
gene id: 9615:CHPT1
uniprot id: A0A8C0RHP3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9615:ZNF24
gene id: 9615:ZNF24
uniprot id: A0A8C0RB55
uniprot id: A0A8I3MZ50
names: Subcellular Location Annotation
messages: Nucleus

9615:SNX33
gene id: 9615:SNX33
uniprot id: A0A8I3PEE8
uniprot id: A0A8P0NJF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9615:TLX1
gene id: 9615:TLX1
uniprot id: A0A8C0TET3
uniprot id: A0A8I3P7G4
names: Subcellular Location Annotation
messages: Nucleus

9615:CUTC
gene id: 9615:CUTC
uniprot id: A0A8C0P777
uniprot id: A0A8C0T1P0
uniprot id: A0A8I3QD47
uniprot id: A0A8I3QQ18
uniprot id: A0A8I3QVE5
uniprot id: A0A8P0SSJ7
names: Similarity
messages: Belongs to the CutC family.

9615:LOC102156144
gene id: 9615:LOC102156144
uniprot id: A0A8C0RTK4
uniprot id: A0A8I3Q6L4
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9615:SEMA6C
gene id: 9615:SEMA6C
uniprot id: A0A8C0SFU0
uniprot id: A0A8I3S2K2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:ADPRHL1
gene id: 9615:ADPRHL1
uniprot id: A0A8C0S7F5
uniprot id: A0A8I3PQJ1
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9615:KCTD20
gene id: 9615:KCTD20
uniprot id: A0A8C0MXU2
uniprot id: A0A8C0Z209
uniprot id: A0A8I3NE05
uniprot id: A0A8P0T6X1
names: Subcellular Location Annotation
messages: Cytoplasm

9615:RAD51
gene id: 9615:RAD51
uniprot id: Q8MKI8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Expressed in the mammary gland.
messages: Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination. Interacts with BRCA1 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and RAD54B. Interacts with the BCDX2 subcomplex RAD51C:RAD51B. Component of the homologous recombination repair (HR) complex composed of ERCC5/XPG, BRCA2, PALB2, DSS1 and RAD51. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1, and this may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer. Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts with SPIDR; the interaction is direct and recruits RAD51 to DNA damage sites. Interacts with FIGNL1 (via N-terminal one-half region); the interaction is direct. Interacts with RAD51AP1 (via C-terminal region); the interaction is direct. Interacts with NABP2, RPA1, PALB2 and RAD51. Interacts with SWI5/C9orf119, and at lower level with SFR1/MEIR5. Interacts with hyperphosphorylated RPA2; this interaction is necessary for efficient recruitment to chromatin in response to DNA damage. Interacts with SWSAP1; involved in homologous recombination repair. Interacts with PARPBP, BRCA2 and RECQL5; these interactions interfere with the formation of the RAD51-DNA homologous recombination structure. Interacts with POLQ; POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends. Interacts with FBH1. Interacts with POLN. Interacts with RFWD3. Interacts with the MCM8-MCM9 complex; the interaction recruits RAD51 to DNA damage sites (By similarity). Component of a multiprotein complex with MEIOB and SPATA22. Interacts with the complex BRME1:HSF2BP:BRCA2 (By similarity). Interacts with HELQ; stimulating HELQ DNA helic…
messages: Mitochondrion matrix
messages: Nucleus
messages: Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair.
messages: Ubiquitinated by the SCF(FBH1) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA. Ubiquitinated by RFWD3 in response to DNA damage: ubiquitination leads to degradation by the proteasome, promoting homologous recombination.
messages: centrosome
messages: perinuclear region

9615:PSME3IP1
gene id: 9615:PSME3IP1
uniprot id: A0A8C0YW64
uniprot id: A0A8I3MPE6
names: Subcellular Location Annotation
messages: Nucleus

9615:XKR8
gene id: 9615:XKR8
uniprot id: A0A8I3NGB4
uniprot id: A0A8P0NDX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9615:IGF1R
gene id: 9615:IGF1R
uniprot id: A0A8C0LVI7
uniprot id: A0A8C0TQ22
uniprot id: A0A8I3MER7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9615:LOC106560188
gene id: 9615:LOC106560188
uniprot id: A0A8C0MM12
uniprot id: A0A8I3NW58
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

9615:LOC100688969
gene id: 9615:LOC100688969
uniprot id: A0A8C0RRE8
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9615:STMN1
gene id: 9615:STMN1
uniprot id: A0A8C0NG77
uniprot id: A0A8I3NR64
uniprot id: A0A8I3P045
uniprot id: A0A8P0THM6
names: Similarity
messages: Belongs to the stathmin family.

9615:XRN2
gene id: 9615:XRN2
uniprot id: A0A8C0P792
uniprot id: A0A8I3PU99
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9615:OR10A5
gene id: 9615:OR10A5
uniprot id: A0A8C0NCJ7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:PSMD4
gene id: 9615:PSMD4
uniprot id: A0A8C0RFH5
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9615:TNFRSF19
gene id: 9615:TNFRSF19
uniprot id: A0A8C0N1R3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:OR10V5
gene id: 9615:OR10V5
uniprot id: A0A8P0SQM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:OST4
gene id: 9615:OST4
uniprot id: P0CU66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST4 family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (By similarity). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:29519914).
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes.

9615:SPTY2D1
gene id: 9615:SPTY2D1
uniprot id: A0A8C0TRE6
names: Similarity
messages: Belongs to the SPT2 family.

9615:DCLK2
gene id: 9615:DCLK2
uniprot id: A0A8C0QIU9
uniprot id: A0A8C0RKU7
uniprot id: A0A8I3NMH3
uniprot id: A0A8I3P196
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9615:COPG1
gene id: 9615:COPG1
uniprot id: A0A8C0Z7D6
uniprot id: A0A8I3PC55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9615:MLH1
gene id: 9615:MLH1
uniprot id: A0A8C0MIS9
uniprot id: A0A8I3PV01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9615:CYP39A1
gene id: 9615:CYP39A1
uniprot id: A0A8C0SF29
uniprot id: A0A8I3NQ76
uniprot id: A0A8I3RX90
uniprot id: A0A8P0S869
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9615:ATP8A1
gene id: 9615:ATP8A1
uniprot id: A0A8C0RI23
uniprot id: A0A8I3NQB5
uniprot id: A0A8P0NRA1
uniprot id: A0A8P0NVF5
uniprot id: A0A8P0THG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:ATRN
gene id: 9615:ATRN
uniprot id: A0A8C0RSH0
uniprot id: A0A8I3NUQ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:ABCC5
gene id: 9615:ABCC5
uniprot id: A0A8I3PVZ3
uniprot id: A0A8P0SH84
names: Subcellular Location Annotation
messages: Membrane

9615:C7H1orf74
gene id: 9615:C7H1orf74
uniprot id: A0A8C0NM71
uniprot id: A0A8I3MGH7
uniprot id: A0A8I3RQZ9
uniprot id: A0A8P0PPM3
names: Similarity
messages: Belongs to the UPF0739 family.

9615:NUCB1
gene id: 9615:NUCB1
uniprot id: A0A8C0PVG8
uniprot id: A0A8I3RP80
names: Similarity
messages: Belongs to the nucleobindin family.

9615:VAMP7
gene id: 9615:VAMP7
uniprot id: A0A8C0N415
uniprot id: A0A8I3NVA5
uniprot id: A0A8I3NW15
uniprot id: A0A8P0PN68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9615:DTX2
gene id: 9615:DTX2
uniprot id: A0A8C0MR52
uniprot id: A0A8I3RTM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9615:MAP4K3
gene id: 9615:MAP4K3
uniprot id: A0A8C0MST1
uniprot id: A0A8I3PP22
uniprot id: A0A8P0SY61
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9615:DHTKD1
gene id: 9615:DHTKD1
uniprot id: A0A8C0Q1B6
uniprot id: A0A8I3RQS7
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9615:MAP4K1
gene id: 9615:MAP4K1
uniprot id: A0A8C0S7V1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9615:H2BC19
gene id: 9615:H2BC19
uniprot id: A0A8C0MIB7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:DEFB105A
gene id: 9615:DEFB105A
uniprot id: F1PK37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:TMEM50B
gene id: 9615:TMEM50B
uniprot id: A0A8C0TWA9
uniprot id: E2RRK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9615:MARCKSL1
gene id: 9615:MARCKSL1
uniprot id: A0A8C0TGC8
uniprot id: A0A8I3MTV8
names: Similarity
messages: Belongs to the MARCKS family.

9615:GP1BA
gene id: 9615:GP1BA
uniprot id: Q28256
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
messages: Glycocalicin is the product of a proteolytic cleavage/shedding, catalyzed by ADAM17, which releases most of the extracellular domain. Binding sites for vWF and thrombin are in this part of the protein.
messages: Membrane
messages: O-glycosylated.
messages: Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.
messages: Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage. Interacts with FLNB. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23).

9615:FAM91A1
gene id: 9615:FAM91A1
uniprot id: A0A8C0MP74
uniprot id: A0A8I3NEI7
names: Similarity
messages: Belongs to the FAM91 family.

9615:TMEM267
gene id: 9615:TMEM267
uniprot id: A0A8C0MF10
uniprot id: A0A8I3MEF8
names: Subcellular Location Annotation
messages: Membrane

9615:MAF1
gene id: 9615:MAF1
uniprot id: A0A8I3NJ58
uniprot id: A0A8P0PD14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

9615:WDR12
gene id: 9615:WDR12
uniprot id: A0A8I3P0V5
uniprot id: A0A8P0SH55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9615:ACKR2
gene id: 9615:ACKR2
uniprot id: A0A8C0SXU3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9615:DBT
gene id: 9615:DBT
uniprot id: A0A8C0NJC4
uniprot id: A0A8I3NPD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9615:POLR2B
gene id: 9615:POLR2B
uniprot id: A0A8I3S0M4
uniprot id: A0A8P0N5D8
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9615:NKAPL
gene id: 9615:NKAPL
uniprot id: A0A8C0S5D2
uniprot id: A0A8I3P175
names: Similarity
messages: Belongs to the NKAP family.

9615:ZSCAN20
gene id: 9615:ZSCAN20
uniprot id: A0A8I3MU02
uniprot id: A0A8P0NCC2
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9615:PTPN6
gene id: 9615:PTPN6
uniprot id: A0A8C0TL66
uniprot id: A0A8I3S5S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9615:KIF15
gene id: 9615:KIF15
uniprot id: A0A8C0Z2D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.
messages: spindle

9615:IL23A
gene id: 9615:IL23A
uniprot id: A0A8C0NA50
uniprot id: A0A8I3N7Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9615:RDH10
gene id: 9615:RDH10
uniprot id: A0A8C0Z005
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:MS4A5
gene id: 9615:MS4A5
uniprot id: A0A8C0QB63
names: Similarity
messages: Belongs to the MS4A family.

9615:CCL16
gene id: 9615:CCL16
uniprot id: A0A8I3N166
uniprot id: A0A8P0NJM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9615:CLCN1
gene id: 9615:CLCN1
uniprot id: Q9MZT1
names: Disease Annotation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily.
messages: Cell membrane
messages: Defects in CLCN1 are the cause of autosomal recessive myotonia congenita (MCR). MCR is a disorder of sarcolemmal excitation leading to delayed relaxation of skeletal muscle following contractions. The disease has been identified in the miniature Schnauzer breed.
messages: Homodimer.
messages: The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (By similarity).
messages: Voltage-gated chloride channel. Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction.

9615:PPP2CA
gene id: 9615:PPP2CA
uniprot id: Q8WN16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9615:RNF121
gene id: 9615:RNF121
uniprot id: A0A8C0TBJ6
uniprot id: A0A8I3NH59
names: Subcellular Location Annotation
messages: Membrane

9615:PSMB2
gene id: 9615:PSMB2
uniprot id: A0A8C0QE86
uniprot id: A0A8I3NUC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9615:SENP5
gene id: 9615:SENP5
uniprot id: A0A8I3QXM3
uniprot id: A0A8P0NF28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9615:ACTN1
gene id: 9615:ACTN1
uniprot id: A0A8C0SG02
uniprot id: A0A8C0SGI7
uniprot id: A0A8C0SIP3
uniprot id: A0A8I3MVW9
names: Similarity
messages: Belongs to the alpha-actinin family.

9615:FSCN1
gene id: 9615:FSCN1
uniprot id: A0A8I3NPK1
uniprot id: A0A8P0NHP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9615:ISM1
gene id: 9615:ISM1
uniprot id: A0A8C0QCX1
uniprot id: A0A8I3PIF5
names: Similarity
messages: Belongs to the isthmin family.

9615:STK11IP
gene id: 9615:STK11IP
uniprot id: A0A8I3S7N5
uniprot id: A0A8P0SK91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STK11IP family.
messages: Cytoplasm

9615:NAXE
gene id: 9615:NAXE
uniprot id: A0A8C0LZE2
uniprot id: A0A8I3RUR7
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.
messages: Homodimer. Interacts with APOA1 and APOA2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

9615:WARS1
gene id: 9615:WARS1
uniprot id: A0A8C0MLF5
uniprot id: A0A8I3MMH0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:HIRIP3
gene id: 9615:HIRIP3
uniprot id: A0A8C0SSH9
uniprot id: A0A8I3MI23
names: Subcellular Location Annotation
messages: Nucleus

9615:VIPAS39
gene id: 9615:VIPAS39
uniprot id: A0A8C0MH94
uniprot id: A0A8I3N7L9
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9615:CELF2
gene id: 9615:CELF2
uniprot id: A0A8C0P5F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9615:IDH1
gene id: 9615:IDH1
uniprot id: A0A8C0MYC5
uniprot id: F1PZA1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Homodimer.

9615:WNT7B
gene id: 9615:WNT7B
uniprot id: A0A8C0MHU1
uniprot id: A0A8C0MR27
uniprot id: A0A8I3N6B8
uniprot id: A0A8I3RVX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9615:CDK4
gene id: 9615:CDK4
uniprot id: A0A8C0T1I9
uniprot id: A0A8I3NU36
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:LGSN
gene id: 9615:LGSN
uniprot id: Q1ZZS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Dodecamer. Interacts with BFSP2 and VIM.
messages: May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity).

9615:CYB5R4
gene id: 9615:CYB5R4
uniprot id: A0A8C0MD08
uniprot id: A0A8I3NKZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

9615:CAMK2G
gene id: 9615:CAMK2G
uniprot id: A0A8C0PS45
uniprot id: A0A8C0PSP6
uniprot id: A0A8C0PT65
uniprot id: A0A8C0PYR2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9615:EGFL8
gene id: 9615:EGFL8
uniprot id: A0A8C0NPA0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SLC46A1
gene id: 9615:SLC46A1
uniprot id: A0A8C0Z2T9
uniprot id: A0A8I3N1L5
names: Subcellular Location Annotation
messages: Membrane

9615:ENTPD5
gene id: 9615:ENTPD5
uniprot id: A0A8C0PHE2
uniprot id: A0A8I3NSC1
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9615:ITGB3
gene id: 9615:ITGB3
uniprot id: Q9TUN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

9615:ZNF280D
gene id: 9615:ZNF280D
uniprot id: A0A8C0Z7D3
uniprot id: A0A8I3Q3X6
uniprot id: A0A8P0NRC6
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9615:GAL3ST1
gene id: 9615:GAL3ST1
uniprot id: A1IGX8
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9615:PARD6A
gene id: 9615:PARD6A
uniprot id: A0A8I3RTL4
uniprot id: A0A8P0SU80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9615:ENTPD2
gene id: 9615:ENTPD2
uniprot id: A0A8C0SI87
uniprot id: A0A8I3PJZ3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9615:USP14
gene id: 9615:USP14
uniprot id: A0A8C0PNC3
uniprot id: A0A8C0PSM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9615:SLC39A7
gene id: 9615:SLC39A7
uniprot id: Q5TJF6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Methylation at some His residue by METTL9 leads to reduced zinc-binding.
messages: Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release.
messages: Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels. Acts as gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation. Has an essential role in B cell development and is required for proper B cell receptor signaling (By similarity). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function. Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts. Mediates Zn(2+)-induced ferroptosis (By similarity).
messages: cis-Golgi network membrane

9615:NMNAT1
gene id: 9615:NMNAT1
uniprot id: A0A8C0SQM7
uniprot id: A0A8I3RQT1
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9615:UBE2G2
gene id: 9615:UBE2G2
uniprot id: A0A8C0PEM6
uniprot id: A0A8C0PR53
uniprot id: A0A8I3S4V5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:RRN3
gene id: 9615:RRN3
uniprot id: A0A8C0Q2E7
uniprot id: A0A8I3NAG1
names: Similarity
messages: Belongs to the RRN3 family.

9615:SERPINA6
gene id: 9615:SERPINA6
uniprot id: A0A8P0SLZ3
names: Similarity
messages: Belongs to the serpin family.

9615:TSC22D4
gene id: 9615:TSC22D4
uniprot id: A0A8C0P0U6
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9615:BAX
gene id: 9615:BAX
uniprot id: A0A8C0RUN2
uniprot id: Q8HYU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

9615:OBP2B
gene id: 9615:OBP2B
uniprot id: O18873
names: Allergen
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Causes an allergic reaction in human.
messages: Secreted
messages: Tongue epithelial tissue.

9615:AUH
gene id: 9615:AUH
uniprot id: A0A8C0M2E9
uniprot id: A0A8C0M2H0
uniprot id: A0A8I3P3A4
uniprot id: A0A8I3PC86
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9615:SLC6A12
gene id: 9615:SLC6A12
uniprot id: P27799
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Cell membrane
messages: Interacts with LIN7C.
messages: Kidney.
messages: Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:10358010). May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation (By similarity). Probably also involved in renal and hepatic osmotic regulation (By similarity).

9615:PPP4R3A
gene id: 9615:PPP4R3A
uniprot id: A0A8C0PWT9
uniprot id: A0A8I3NRE9
names: Similarity
messages: Belongs to the SMEK family.

9615:NDUFB4
gene id: 9615:NDUFB4
uniprot id: A0A8C0Z2F3
uniprot id: A0A8I3P7K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:DIP2B
gene id: 9615:DIP2B
uniprot id: A0A8C0PD19
uniprot id: A0A8I3P834
names: Similarity
messages: Belongs to the DIP2 family.

9615:OR10Q1
gene id: 9615:OR10Q1
uniprot id: A0A8C0SF73
uniprot id: A0A8I3PCT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CCR6
gene id: 9615:CCR6
uniprot id: A0A8C0PSS4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:TMEM59
gene id: 9615:TMEM59
uniprot id: A0A8C0M8D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:TMEM14A
gene id: 9615:TMEM14A
uniprot id: A0A8C0QBY5
names: Similarity
messages: Belongs to the TMEM14 family.

9615:GPLD1
gene id: 9615:GPLD1
uniprot id: A0A8P0PCS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

9615:LOC100683370
gene id: 9615:LOC100683370
uniprot id: A0A8C0S7Q9
uniprot id: A0A8I3PVX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9615:FAM207A
gene id: 9615:FAM207A
uniprot id: A0A8C0PEE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

9615:DOLPP1
gene id: 9615:DOLPP1
uniprot id: A0A8C0S5H0
uniprot id: A0A8I3PL72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9615:CCDC167
gene id: 9615:CCDC167
uniprot id: A0A8C0Z2X1
names: Subcellular Location Annotation
messages: Membrane

9615:BRS3
gene id: 9615:BRS3
uniprot id: A0A8C0TSB1
uniprot id: A0A8I3Q0U9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9615:LAMC2
gene id: 9615:LAMC2
uniprot id: Q867A2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9615:EZR
gene id: 9615:EZR
uniprot id: A0A8C0NAG2
uniprot id: A0A8I3MKE1
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9615:SCAI
gene id: 9615:SCAI
uniprot id: A0A8C0MDU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAI family.
messages: Cytoplasm
messages: Interacts with DIAPH1. Forms a nuclear ternary complex with MRTFA and SRF.
messages: Nucleus
messages: Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity.

9615:CEP70
gene id: 9615:CEP70
uniprot id: A0A8C0NBU5
uniprot id: A0A8I3PV14
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

9615:MAGI3
gene id: 9615:MAGI3
uniprot id: A0A8C0NU54
uniprot id: A0A8C0P4L5
names: Subcellular Location Annotation
messages: Membrane

9615:WASF3
gene id: 9615:WASF3
uniprot id: A0A8C0T7X7
uniprot id: A0A8I3PXN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9615:THRA
gene id: 9615:THRA
uniprot id: A0A8C0PT61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9615:DDIT3
gene id: 9615:DDIT3
uniprot id: A0A8C0MS70
uniprot id: A0A8I3NHJ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9615:FMR1
gene id: 9615:FMR1
uniprot id: A0A8C0NG67
uniprot id: A0A8C0NQG5
uniprot id: A0A8I3PAW4
uniprot id: A0A8I3PB79
uniprot id: A0A8P0T0D3
uniprot id: A0A8P0TBR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Stress granule
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

9615:AP3S2
gene id: 9615:AP3S2
uniprot id: A0A8C0LZK8
uniprot id: A0A8I3MH13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9615:TAP1
gene id: 9615:TAP1
uniprot id: A0A8C0T6K4
uniprot id: H8ZYY3
uniprot id: Q5W414
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

9615:LSM6
gene id: 9615:LSM6
uniprot id: A0A8C0Q5G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9615:S100A6
gene id: 9615:S100A6
uniprot id: A0A8C0PYT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
messages: Nucleus envelope

9615:PIK3CG
gene id: 9615:PIK3CG
uniprot id: A0A8C0RPI8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9615:GMNN
gene id: 9615:GMNN
uniprot id: A0A8C0NPS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9615:OTC
gene id: 9615:OTC
uniprot id: A0A8C0N9Z3
uniprot id: A0A8I3S5H5
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9615:SERPINH1
gene id: 9615:SERPINH1
uniprot id: A0A8P0SAZ3
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

9615:ATP6V0D2
gene id: 9615:ATP6V0D2
uniprot id: A0A8C0MQX9
uniprot id: A0A8I3NSM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9615:GDPD5
gene id: 9615:GDPD5
uniprot id: A0A8C0NR65
uniprot id: A0A8C0NUU6
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9615:HEATR5B
gene id: 9615:HEATR5B
uniprot id: A0A8P0SBG6
names: Similarity
messages: Belongs to the HEATR5 family.

9615:CNOT8
gene id: 9615:CNOT8
uniprot id: A0A8C0QJZ8
uniprot id: A0A8I3MRJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9615:CD38
gene id: 9615:CD38
uniprot id: Q9N262
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9615:RBL1
gene id: 9615:RBL1
uniprot id: A0A8C0SJ08
uniprot id: A0A8I3Q0G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9615:MLST8
gene id: 9615:MLST8
uniprot id: A0A8C0RUG6
uniprot id: A0A8I3MX71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9615:CETN1
gene id: 9615:CETN1
uniprot id: A0A8C0NMF1
uniprot id: A0A8I3RRP1
names: Similarity
messages: Belongs to the centrin family.

9615:POU1F1
gene id: 9615:POU1F1
uniprot id: Q9TTI7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Interacts with PITX1. Interacts with LHX3. Interacts with ELK1.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

9615:SCGB1A1
gene id: 9615:SCGB1A1
uniprot id: A0A8C0MBH7
uniprot id: E2R0A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9615:NR4A1
gene id: 9615:NR4A1
uniprot id: P51666
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1 (By similarity).
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: Binds 2 zinc ions.
messages: Binds the NGFI-B response element (NBRE) as a monomer (By similarity). Binds the Nur response element (NurRE), consisting of two inverse NBRE-related octanucleotide repeats separated by 6 base-pairs, as a dimer (By similarity). Interacts (via N-terminus) with NLRP3 (via LRR repeat domain); the interaction is direct, requires binding of NR4A1/Nur77 to NBRE-containing dsDNA and lipopolysaccharide, and leads to non-canonical NLRP3 inflammasome activation (By similarity). Interacts with GADD45GIP1. Interacts with STK11. Heterodimer (via DNA-binding domain) with RXRA (via C-terminus); DNA-binding of the heterodimer is enhanced by 9-cis retinoic acid (By similarity). Competes for the RXRA interaction with EP300 and thereby attenuates EP300 mediated acetylation of RXRA (By similarity). Interacts with NCOA1 (By similarity). Interacts with NCOA2 (By similarity). Interacts with NCOA3 (By similarity).
messages: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7.
messages: Mitochondrion
messages: Nucleus
messages: Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (By similarity). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (By similarity). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (By similarity). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity).
messages: Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.
messages: The NR LBD domain binds the lipid A moiety of lipopolysaccharide (LPS) in the cytosol.
messages: cytosol

9615:YIF1A
gene id: 9615:YIF1A
uniprot id: A0A8C0SJU2
uniprot id: A0A8I3NTF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9615:IFRD1
gene id: 9615:IFRD1
uniprot id: A0A8C0SR51
uniprot id: A0A8I3Q982
names: Similarity
messages: Belongs to the IFRD family.

9615:NSRP1
gene id: 9615:NSRP1
uniprot id: A0A8C0MLR7
uniprot id: A0A8I3NI25
names: Similarity
messages: Belongs to the NSRP1 family.

9615:GNG12
gene id: 9615:GNG12
uniprot id: A0A8C0Q8X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:DAPK2
gene id: 9615:DAPK2
uniprot id: A0A8I3PIC8
uniprot id: A0A8P0NN73
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:TRAF2
gene id: 9615:TRAF2
uniprot id: A0A8C0MD65
uniprot id: A0A8I3MQC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9615:SLC5A11
gene id: 9615:SLC5A11
uniprot id: A0A8C0PUK3
uniprot id: A0A8I3RR05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9615:UBAC2
gene id: 9615:UBAC2
uniprot id: A0A8I3P9G5
names: Subcellular Location Annotation
messages: Membrane

9615:ADTRP
gene id: 9615:ADTRP
uniprot id: A0A8I3PJI4
uniprot id: A0A8P0NMM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9615:ABCD1
gene id: 9615:ABCD1
uniprot id: A0A8C0T0G0
uniprot id: A0A8I3PH78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9615:CKAP2L
gene id: 9615:CKAP2L
uniprot id: A0A8C0RCV8
uniprot id: A0A8C0RCY4
names: Similarity
messages: Belongs to the CKAP2 family.

9615:KDM5C
gene id: 9615:KDM5C
uniprot id: Q38JA7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the JARID1 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Both the JmjC domain and the JmjN domain are required for enzymatic activity.
messages: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
messages: Nucleus
messages: Part of two distinct complexes, one containing E2F6, and the other containing REST. Interacts with ZMYND8.
messages: The first PHD-type zinc finger domain recognizes and binds H3-K9Me3.

9615:C26H12orf65
gene id: 9615:C26H12orf65
uniprot id: A0A8I3P696
uniprot id: A0A8P0N9Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9615:KIFBP
gene id: 9615:KIFBP
uniprot id: A0A8C0Q6M8
uniprot id: A0A8I3MUW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

9615:PDXK
gene id: 9615:PDXK
uniprot id: A0A8P0PDH8
names: Similarity
messages: Belongs to the pyridoxine kinase family.

9615:BORCS8
gene id: 9615:BORCS8
uniprot id: A0A8C0TI26
uniprot id: A0A8I3PCU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

9615:ISCA1
gene id: 9615:ISCA1
uniprot id: A0A8I3MXR4
uniprot id: A0A8P0PMT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9615:MGA
gene id: 9615:MGA
uniprot id: A0A8P0SEK4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:VAMP1
gene id: 9615:VAMP1
uniprot id: A0A8C0T8Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9615:PGAM2
gene id: 9615:PGAM2
uniprot id: A0A8C0TNC0
uniprot id: A0A8I3NE41
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9615:PDE4B
gene id: 9615:PDE4B
uniprot id: A0A8C0M3Z2
uniprot id: A0A8C0M947
uniprot id: A0A8C0QIS1
uniprot id: A0A8C0QIV5
uniprot id: A0A8I3PZX6
uniprot id: A0A8I3Q1G8
uniprot id: A0A8I3SBV2
uniprot id: A0A8I3SBZ4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:GCNT2
gene id: 9615:GCNT2
uniprot id: A0A8C0RJN6
uniprot id: A0A8I3P909
uniprot id: A0A8I3PEJ2
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9615:SPRING1
gene id: 9615:SPRING1
uniprot id: A0A8C0P4T4
uniprot id: A0A8I3PLS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

9615:C5H11orf1
gene id: 9615:C5H11orf1
uniprot id: A0A8P0NUZ0
uniprot id: A0A8P0PHC7
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

9615:CDX2
gene id: 9615:CDX2
uniprot id: A0A8C0P362
uniprot id: A0A8I3PU71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9615:IL1R1
gene id: 9615:IL1R1
uniprot id: A0A8C0QF36
uniprot id: A0A8C0QLC9
uniprot id: A0A8I3NH34
uniprot id: A0A8I3RY59
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9615:OR6C74
gene id: 9615:OR6C74
uniprot id: A0A8C0NTI3
uniprot id: F1Q4H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CRYBB2
gene id: 9615:CRYBB2
uniprot id: Q2LEC2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).

9615:SLC27A1
gene id: 9615:SLC27A1
uniprot id: A0A8C0SLA2
uniprot id: A0A8I3PTX2
uniprot id: A0A8P0PAC2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:TATDN3
gene id: 9615:TATDN3
uniprot id: A0A8C0MJ72
uniprot id: A0A8C0MQF8
uniprot id: A0A8I3MLI9
uniprot id: A0A8I3MNC8
uniprot id: A0A8P0NED8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9615:KRT33B
gene id: 9615:KRT33B
uniprot id: A0A8C0NSP5
uniprot id: A0A8I3NNI9
names: Similarity
messages: Belongs to the intermediate filament family.

9615:CRYZ
gene id: 9615:CRYZ
uniprot id: A0A8C0NY94
uniprot id: A0A8I3MU73
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9615:SEPTIN8
gene id: 9615:SEPTIN8
uniprot id: A0A8C0NA87
uniprot id: A0A8I3NEQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9615:TSSC4
gene id: 9615:TSSC4
uniprot id: A0A8C0TT89
uniprot id: A0A8I3NUR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TSSC4 family.
messages: Cytoplasm
messages: Nucleus

9615:RASGRP2
gene id: 9615:RASGRP2
uniprot id: A0A8I3Q8A5
uniprot id: A0A8P0NG65
names: Similarity
messages: Belongs to the RASGRP family.

9615:EXOC2
gene id: 9615:EXOC2
uniprot id: A0A8C0REU8
uniprot id: A0A8I3P3F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9615:CTNND1
gene id: 9615:CTNND1
uniprot id: A0A8C0MG46
uniprot id: A0A8C0SIL9
uniprot id: A0A8I3P855
uniprot id: A0A8I3P8H1
uniprot id: A0A8P0NAA2
names: Similarity
messages: Belongs to the beta-catenin family.

9615:FXYD2
gene id: 9615:FXYD2
uniprot id: A0A8C0MSH3
uniprot id: A0A8I3MV55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FXYD family.
messages: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
messages: Membrane
messages: Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

9615:UBA3
gene id: 9615:UBA3
uniprot id: A0A8C0S5E2
uniprot id: A0A8C0S5Y5
uniprot id: A0A8I3NAK8
uniprot id: A0A8I3NEL0
uniprot id: A0A8I3NHJ7
uniprot id: A0A8P0TKJ1
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

9615:SKA2
gene id: 9615:SKA2
uniprot id: A0A8C0PWE8
uniprot id: A0A8I3PLL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

9615:TIGD4
gene id: 9615:TIGD4
uniprot id: A0A8C0N1C2
uniprot id: A0A8I3N763
names: Subcellular Location Annotation
messages: Nucleus

9615:MC4R
gene id: 9615:MC4R
uniprot id: A0A8C0Q121
uniprot id: Q4JIV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9615:LOC612537
gene id: 9615:LOC612537
uniprot id: A0A8I3MWB9
uniprot id: A0A8P0N433
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:CCDC56
gene id: 9615:CCDC56
uniprot id: A0A8C0T9Q4
uniprot id: A0A8I3N8V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9615:CD8A
gene id: 9615:CD8A
uniprot id: P33706
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms disulfide-linked heterodimers with CD8B at the cell surface. Forms also homodimers in several cell types including NK-cells or peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.
messages: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
messages: O-glycosylated.
messages: Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.
messages: Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.

9615:GRAMD1A
gene id: 9615:GRAMD1A
uniprot id: A0A8C0Q3Q2
uniprot id: A0A8I3MS15
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:GSX1
gene id: 9615:GSX1
uniprot id: A0A8C0P1A5
uniprot id: A0A8I3PQR6
names: Subcellular Location Annotation
messages: Nucleus

9615:UCN2
gene id: 9615:UCN2
uniprot id: A0A8C0NVK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9615:PANX1
gene id: 9615:PANX1
uniprot id: A0A8C0T182
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9615:ATP6V0A4
gene id: 9615:ATP6V0A4
uniprot id: A0A8C0NC39
uniprot id: A0A8I3ND81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9615:PLA2G2E
gene id: 9615:PLA2G2E
uniprot id: A0A8P0PGG4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9615:FGD3
gene id: 9615:FGD3
uniprot id: A0A8C0PUA5
uniprot id: A0A8I3PKM6
names: Subcellular Location Annotation
messages: cytoskeleton

9615:PDRG1
gene id: 9615:PDRG1
uniprot id: A0A8C0MZZ5
uniprot id: A0A8I3PB75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9615:TUBA4A
gene id: 9615:TUBA4A
uniprot id: A0A8C0MZ87
uniprot id: A0A8I3Q1H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:GRPEL2
gene id: 9615:GRPEL2
uniprot id: A0A8C0Q8E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9615:GABARAPL2
gene id: 9615:GABARAPL2
uniprot id: A0A8C0M237
uniprot id: A0A8I3PFI1
names: Similarity
messages: Belongs to the ATG8 family.

9615:ZFYVE26
gene id: 9615:ZFYVE26
uniprot id: A0A8C0NEE1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.
messages: Midbody
messages: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

9615:TFIP11
gene id: 9615:TFIP11
uniprot id: A1XD97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2 (By similarity).
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity).
messages: Nucleus

9615:ARSJ
gene id: 9615:ARSJ
uniprot id: A0A8C0TUP8
uniprot id: Q32KH6
names: Similarity
messages: Belongs to the sulfatase family.

9615:ALDH1B1
gene id: 9615:ALDH1B1
uniprot id: A0A8C0SUI3
uniprot id: A0A8I3NPF7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:IL7
gene id: 9615:IL7
uniprot id: A0A8C0N6M5
uniprot id: Q0MUT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Secreted

9615:STX5
gene id: 9615:STX5
uniprot id: A0A8C0MMT1
uniprot id: A0A8I3N2I9
names: Similarity
messages: Belongs to the syntaxin family.

9615:BMP5
gene id: 9615:BMP5
uniprot id: A0A8C0NEM6
uniprot id: A0A8I3RYW2
names: Similarity
messages: Belongs to the TGF-beta family.

9615:LTBP4
gene id: 9615:LTBP4
uniprot id: A0A8I3RSV2
uniprot id: A0A8P0N7S6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:LOC481674
gene id: 9615:LOC481674
uniprot id: H2B3G5
names: Allergen
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Causes an allergic reaction in human. Binds to IgE (PubMed:22104604, PubMed:22515174, PubMed:23464525, PubMed:23464491, PubMed:29207604, PubMed:30728436). Binds to IgE in 61% of the 44 patients tested allergic to both dog and cat dander (PubMed:22104604). Binds to IgE in 38% of the 100 patients tested allergic to dog dander (PubMed:22515174). Binds to IgE in all 3 patients tested allergic to both dog and horse dander (PubMed:23464491). Binds to IgE in 56% of the 32 Chinese children tested allergic to dog (PubMed:29207604). Binds to IgE in 47% of the 38 patients tested allergic to dog dander (PubMed:30728436). Causes activation of human basophils (PubMed:22515174, PubMed:29207604).
messages: Expressed in saliva (at protein level) (PubMed:23464525). Expressed in dander (at protein level) (PubMed:22515174, PubMed:23464525). According to PubMed:22104604, expressed in submaxillary gland (PubMed:22104604). In contrast, according to PubMed:22515174, not expressed in submaxillary gland. Expressed in bladder and skin, but not in tongue (PubMed:22515174).
messages: Monomer.
messages: Secreted

9615:EMP1
gene id: 9615:EMP1
uniprot id: A0A8P0SR25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9615:ACER1
gene id: 9615:ACER1
uniprot id: A0A8C0TTX6
uniprot id: A0A8I3RYI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9615:OLFML2A
gene id: 9615:OLFML2A
uniprot id: A0A8C0TH30
uniprot id: A0A8I3N9Z5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:COMP
gene id: 9615:COMP
uniprot id: A0A8C0TLZ8
uniprot id: A0A8I3P787
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:KREMEN1
gene id: 9615:KREMEN1
uniprot id: A0A8I3Q3U5
uniprot id: A0A8P0THV3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:GH1
gene id: 9615:GH1
uniprot id: A0A0M6L0Q5
uniprot id: P33711
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9615:RIMBP2
gene id: 9615:RIMBP2
uniprot id: A0A8P0PEL6
names: Similarity
messages: Belongs to the RIMBP family.

9615:BARHL1
gene id: 9615:BARHL1
uniprot id: A0A8C0Q0X9
uniprot id: A0A8I3S2B4
names: Subcellular Location Annotation
messages: Nucleus

9615:ITGB2
gene id: 9615:ITGB2
uniprot id: A0A8C0Z0G4
uniprot id: A0A8I3S561
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft

9615:AIF1
gene id: 9615:AIF1
uniprot id: A0A8C0YTZ5
uniprot id: A0A8I3NIF7
names: Subcellular Location Annotation
messages: ruffle membrane

9615:RPL22L1
gene id: 9615:RPL22L1
uniprot id: A0A8C0YWJ8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9615:FGF21
gene id: 9615:FGF21
uniprot id: A0A8C0N592
uniprot id: E2RRP8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:TAS2R3
gene id: 9615:TAS2R3
uniprot id: A0A8C0QB49
uniprot id: Q2ABD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:TFCP2
gene id: 9615:TFCP2
uniprot id: A0A8C0TCG7
uniprot id: A0A8I3NXD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9615:GANC
gene id: 9615:GANC
uniprot id: A0A8P0SF64
uniprot id: A0A8P0SSZ9
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9615:POU2F1
gene id: 9615:POU2F1
uniprot id: A0A8C0P843
uniprot id: A0A8C0PCZ0
uniprot id: A0A8I3MPV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9615:NEMF
gene id: 9615:NEMF
uniprot id: A0A8C0LUQ6
uniprot id: A0A8I3MFD7
names: Similarity
messages: Belongs to the NEMF family.

9615:HHATL
gene id: 9615:HHATL
uniprot id: A0A8C0NK81
names: Subcellular Location Annotation
messages: Membrane

9615:NCK1
gene id: 9615:NCK1
uniprot id: A0A8C0TTD9
uniprot id: A0A8I3S602
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9615:CAPN15
gene id: 9615:CAPN15
uniprot id: A0A8C0S1Y9
uniprot id: A0A8I3Q036
names: Similarity
messages: Belongs to the peptidase C2 family.

9615:ANAPC13
gene id: 9615:ANAPC13
uniprot id: A0A8C0MQG9
uniprot id: A0A8I3QJ90
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9615:BARHL2
gene id: 9615:BARHL2
uniprot id: A0A8P0SP23
names: Subcellular Location Annotation
messages: Nucleus

9615:CHRNG
gene id: 9615:CHRNG
uniprot id: A0A8C0TT36
uniprot id: A0A8I3S5M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:TMEM87A
gene id: 9615:TMEM87A
uniprot id: A0A8C0P778
uniprot id: A0A8I3P6U1
names: Subcellular Location Annotation
messages: Membrane

9615:RPL7
gene id: 9615:RPL7
uniprot id: A0A8C0MG43
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9615:TNFRSF1B
gene id: 9615:TNFRSF1B
uniprot id: A0A8C0Q928
uniprot id: A0A8I3MDX6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:OR5P4
gene id: 9615:OR5P4
uniprot id: A0A8C0RIA8
uniprot id: A0A8I3NGY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:TBXT
gene id: 9615:TBXT
uniprot id: Q9GL27
names: Function
names: Polymorphism
names: Subcellular Location Annotation
names: Subunit
messages: A mutation in position 63 is responsible for a short-tail trait in a bob-tailed dog (PubMed:11252170). The homozygous mutation is lethal (PubMed:11252170).
messages: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.
messages: Monomer. Binds DNA as a monomer.
messages: Nucleus

9615:TPM2
gene id: 9615:TPM2
uniprot id: A0A8C0MXG3
uniprot id: A0A8C0N3P5
uniprot id: A0A8I3N002
uniprot id: A0A8I3NAC0
uniprot id: A0A8I3RWJ7
uniprot id: E2RAH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9615:AICDA
gene id: 9615:AICDA
uniprot id: Q75W64
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm
messages: Expressed in thymus, lung, spleen, kidney, small intestine, lymph node and tonsil.
messages: Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1. Interacts with SUPT6H, TRIM28 and NCL. Directly interacts with MCM3AP; this interaction may favor AICDA recruitment to immunoglobulin variable region genes, hence promoting somatic hypermutations (By similarity).
messages: Nucleus
messages: Probably monoubiquitinated on several residues by RNF126.
messages: Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity (By similarity).
messages: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

9615:SAP30
gene id: 9615:SAP30
uniprot id: A0A8C0NXI2
uniprot id: A0A8I3P1N2
names: Similarity
messages: Belongs to the SAP30 family.

9615:H1-0
gene id: 9615:H1-0
uniprot id: A0A8C0QLP7
uniprot id: A0A8I3RUA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9615:ZP2
gene id: 9615:ZP2
uniprot id: P47983
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZP domain family. ZPA subfamily.
messages: Can form homopolymers that assemble into long fibers (in vitro). Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers. Interacts with ZP3.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
messages: N-glycosylated.
messages: O-glycosylated; contains sulfate-substituted glycans.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9615:COPS8
gene id: 9615:COPS8
uniprot id: A0A8C0T1W3
uniprot id: A0A8I3PVK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9615:ZCCHC4
gene id: 9615:ZCCHC4
uniprot id: A0A8C0M8S0
uniprot id: A0A8I3N825
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

9615:EZH2
gene id: 9615:EZH2
uniprot id: A0A8C0MNG5
uniprot id: A0A8C0QLE9
uniprot id: A0A8I3NMC2
names: Subcellular Location Annotation
messages: Nucleus

9615:PTGES
gene id: 9615:PTGES
uniprot id: A0SYQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAPEG family.
messages: Homotrimer.
messages: Membrane
messages: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).
messages: perinuclear region

9615:GPR87
gene id: 9615:GPR87
uniprot id: A0A8C0N871
uniprot id: A0A8I3QCS2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:KIF5B
gene id: 9615:KIF5B
uniprot id: A0A8C0NXA2
uniprot id: A0A8I3N413
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:HBP1
gene id: 9615:HBP1
uniprot id: A0A8C0RPN3
uniprot id: A0A8C0SKG7
uniprot id: A0A8I3PTY0
uniprot id: A0A8I3SA23
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9615:KPNB1
gene id: 9615:KPNB1
uniprot id: A0A8C0M352
uniprot id: A0A8I3NZP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

9615:PDE5A
gene id: 9615:PDE5A
uniprot id: O77746
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 1 Mg(2+) ions per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Binds magnesium less tightly than zinc.
messages: Binds 1 Zn(2+) ion per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Tightly binds zinc.
messages: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B.
messages: Cytoplasm
messages: Inhibited by zaprinast.
messages: Isoform PDE5A1 and isoform PDE5A2 are highly expressed in the cerebellum, hippocampus, retina, lung, heart, spleen, and thoracic artery. Isoform PDE5A1, but not isoform PDE5A2, is also abundantly expressed in the pylorus.
messages: Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation.
messages: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
messages: cGMP-binding to the allosteric sites is stimulated by 3-isobutyl-1-methylxanthine (IBMX).
messages: cytosol

9615:SMARCD2
gene id: 9615:SMARCD2
uniprot id: A0A8C0SXK6
uniprot id: A0A8C0T104
names: Similarity
messages: Belongs to the SMARCD family.

9615:HBM
gene id: 9615:HBM
uniprot id: A0A8C0MNQ0
uniprot id: A0A8I3MHE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9615:BARX2
gene id: 9615:BARX2
uniprot id: A0A8P0SF37
names: Subcellular Location Annotation
messages: Nucleus

9615:STARD6
gene id: 9615:STARD6
uniprot id: A0A8C0MEE3
uniprot id: A0A8I3N3G7
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9615:HOXC4
gene id: 9615:HOXC4
uniprot id: A0A8C0Z2X9
uniprot id: A0A8I3NZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:TMEM176A
gene id: 9615:TMEM176A
uniprot id: A0A8C0PM27
names: Similarity
messages: Belongs to the TMEM176 family.

9615:PIPOX
gene id: 9615:PIPOX
uniprot id: A0A8C0MVR2
uniprot id: A0A8I3NCN7
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9615:LYG1
gene id: 9615:LYG1
uniprot id: A0A8C0NT03
uniprot id: A0A8I3P497
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9615:ING5
gene id: 9615:ING5
uniprot id: A0A8C0Z6P3
uniprot id: A0A8I3PQF3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9615:LOC100688441
gene id: 9615:LOC100688441
uniprot id: A0A8C0NTE3
uniprot id: A0A8I3PMR1
names: Similarity
messages: Belongs to the BEX family.

9615:FAM219A
gene id: 9615:FAM219A
uniprot id: A0A8I3PNW3
uniprot id: A0A8P0TL40
names: Similarity
messages: Belongs to the FAM219 family.

9615:ST6GAL1
gene id: 9615:ST6GAL1
uniprot id: A0A8C0T0L0
uniprot id: A0A8I3S5C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:PSKH2
gene id: 9615:PSKH2
uniprot id: A0A8C0TI45
uniprot id: A0A8I3P4I8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:ACTN3
gene id: 9615:ACTN3
uniprot id: A0A8C0NSN0
names: Similarity
messages: Belongs to the alpha-actinin family.

9615:LONP2
gene id: 9615:LONP2
uniprot id: A0A8C0N6W4
uniprot id: A0A8C0RHX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
messages: Belongs to the peptidase S16 family.
messages: Interacts with PEX5. Interacts with TYSND1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Peroxisome matrix

9615:CLCN5
gene id: 9615:CLCN5
uniprot id: A0A8I3PXT2
uniprot id: A0A8P0TDI8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:SRRT
gene id: 9615:SRRT
uniprot id: A0A8I3MWW9
uniprot id: A0A8P0SIT0
names: Similarity
messages: Belongs to the ARS2 family.

9615:CFL1
gene id: 9615:CFL1
uniprot id: A0A8C0NGL0
uniprot id: A0A8I3P3F3
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9615:SLC39A8
gene id: 9615:SLC39A8
uniprot id: A0A8C0P5E2
names: Subcellular Location Annotation
messages: Membrane

9615:ITGA7
gene id: 9615:ITGA7
uniprot id: A0A8C0N9S2
uniprot id: A0A8C0Q2Y5
uniprot id: A0A8C0RWV8
uniprot id: A0A8C0RWX2
uniprot id: A0A8I3MVF8
uniprot id: A0A8I3NBB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:OR8U9
gene id: 9615:OR8U9
uniprot id: A0A8C0M6S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:TMEM256
gene id: 9615:TMEM256
uniprot id: A0A8C0QET2
uniprot id: A0A8I3PIS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9615:LOC489748
gene id: 9615:LOC489748
uniprot id: A0A8I3RZ66
uniprot id: A0A8P0SPB2
names: Subcellular Location Annotation
messages: Membrane

9615:C5AR2
gene id: 9615:C5AR2
uniprot id: A0A8C0RW99
uniprot id: A0A8I3RQX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

9615:CDK9
gene id: 9615:CDK9
uniprot id: A0A8C0N0A9
uniprot id: A0A8I3MNV9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:MYH4
gene id: 9615:MYH4
uniprot id: Q076A5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-4 (MYO4).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9615:CHD2
gene id: 9615:CHD2
uniprot id: A0A8C0MA63
uniprot id: A0A8C0TTC3
names: Subcellular Location Annotation
messages: Nucleus

9615:RPN1
gene id: 9615:RPN1
uniprot id: E2RQ08
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:12887896, PubMed:15835887, PubMed:25135935). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:29519914). Interacts with TMEM35A/NACHO (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
messages: Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

9615:CDC25A
gene id: 9615:CDC25A
uniprot id: A0A8C0TR13
uniprot id: A0A8I3RVA5
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9615:MEA1
gene id: 9615:MEA1
uniprot id: A0A8C0RJP7
uniprot id: A0A8I3MW43
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

9615:SAE1
gene id: 9615:SAE1
uniprot id: A0A8C0Q9T2
uniprot id: A0A8I3MIJ2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9615:OTX1
gene id: 9615:OTX1
uniprot id: A0A8C0RXS0
uniprot id: A0A8I3NZB7
names: Subcellular Location Annotation
messages: Nucleus

9615:CD79A
gene id: 9615:CD79A
uniprot id: P0CAN6
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).
messages: Cell membrane
messages: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-207, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity (By similarity).
messages: Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases, including LYN, is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation (By similarity).
messages: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells (By similarity).

9615:TMED4
gene id: 9615:TMED4
uniprot id: A0A8C0TP25
uniprot id: A0A8I3NGF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:C6H1orf52
gene id: 9615:C6H1orf52
uniprot id: A0A8C0NII7
uniprot id: A0A8I3RPP3
names: Similarity
messages: Belongs to the UPF0690 family.

9615:CDKN2AIP
gene id: 9615:CDKN2AIP
uniprot id: A0A8C0SPQ4
names: Similarity
messages: Belongs to the CARF family.

9615:GPX8
gene id: 9615:GPX8
uniprot id: A0A8C0MGU0
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9615:TRMT2A
gene id: 9615:TRMT2A
uniprot id: A0A8C0RNG0
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SEC22B
gene id: 9615:SEC22B
uniprot id: A0A8P0NWL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9615:LOC607396
gene id: 9615:LOC607396
uniprot id: A0A8P0NC25
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9615:BCAP31
gene id: 9615:BCAP31
uniprot id: A0A8C0T297
uniprot id: A0A8I3Q0S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9615:SEPTIN6
gene id: 9615:SEPTIN6
uniprot id: A0A8C0SLX1
uniprot id: A0A8C0SMA7
uniprot id: A0A8C0SQY4
uniprot id: A0A8I3PE43
uniprot id: A0A8I3S249
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9615:RPL31
gene id: 9615:RPL31
uniprot id: A0A8C0RQC2
uniprot id: E2R8G3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9615:TUBB
gene id: 9615:TUBB
uniprot id: A0A8C0SSP9
uniprot id: A0A8I3N9K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:POLR2G
gene id: 9615:POLR2G
uniprot id: A0A8C0T141
uniprot id: A0A8I3MXA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9615:ERCC5
gene id: 9615:ERCC5
uniprot id: A0A8P0SVU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

9615:VTI1B
gene id: 9615:VTI1B
uniprot id: A0A8C0RLI9
uniprot id: A0A8I3MP68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9615:CYP17A1
gene id: 9615:CYP17A1
uniprot id: A0A8C0PJZ0
uniprot id: A0A8C0TRG3
uniprot id: A0A8I3PR85
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:AGPAT1
gene id: 9615:AGPAT1
uniprot id: A0A8I3NV03
uniprot id: A0A8P0NMQ2
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9615:CLDN4
gene id: 9615:CLDN4
uniprot id: A0A8C0N7E5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:USP39
gene id: 9615:USP39
uniprot id: A0A8C0Q6J3
uniprot id: A0A8I3NIC3
names: Subcellular Location Annotation
messages: Nucleus

9615:HOMER3
gene id: 9615:HOMER3
uniprot id: A0A8C0THM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9615:CACNA1S
gene id: 9615:CACNA1S
uniprot id: A0A8C0PGF9
uniprot id: A0A8C0RSY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9615:PDGFRB
gene id: 9615:PDGFRB
uniprot id: Q6QNF3
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-579, and to a lesser degree, Tyr-581 is important for interaction with SRC. Phosphorylation at Tyr-716 is important for interaction with GRB2. Phosphorylation at Tyr-740 and Tyr-751 is important for interaction with PIK3R1. Phosphorylation at Tyr-751 is important for interaction with NCK1. Phosphorylation at Tyr-771 and Tyr-857 is important for interaction with RASA1/GAP. Phosphorylation at Tyr-857 is important for efficient phosphorylation of PLCG1 and PTPN11, resulting in increased phosphorylation of AKT1, MAPK1/ERK2 and/or MAPK3/ERK1, PDCD6IP/ALIX and STAM, and in increased cell proliferation. Phosphorylation at Tyr-1009 is important for interaction with PTPN11. Phosphorylation at Tyr-1009 and Tyr-1021 is important for interaction with PLCG1. Dephosphorylated by PTPRJ at Tyr-751, Tyr-857, Tyr-1009 and Tyr-1021 (By similarity). Dephosphorylated by PTPN2 at Tyr-579 and Tyr-1021 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB. May also interact with homodimeric PDGFC. Monomer in the absence of bound ligand. Interaction with homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD, leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts with SH2B2/APS. Interacts directly (tyrosine phosphorylated) with SHB. Interacts (tyrosine phosphorylated) with PIK3R1 and RASA1. Interacts (tyrosine phosphorylated) with CBL. Interacts (tyrosine phosphorylated) with SRC and SRC family kinases. Interacts (tyrosine phosphorylated) with PIK3C2B, maybe indirectly. Interacts (tyrosine phosphorylated) with SHC1, GRB7, GRB10 and NCK1. Interaction with GRB2 is mediated by SHC1. Interacts (via C-terminus) with NHERF1 (By similarity).
messages: Lysosome lumen
messages: N-glycosylated.
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFB and/or PDGFD leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the…
messages: Ubiquitinated. After autophosphorylation, the receptor is polyubiquitinated, leading to its degradation (By similarity).

9615:LIMS2
gene id: 9615:LIMS2
uniprot id: A0A8C0MC49
uniprot id: A0A8I3P7C0
uniprot id: A0A8I3PK36
uniprot id: A0A8P0TT20
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9615:OR7A23
gene id: 9615:OR7A23
uniprot id: A0A8P0STH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ENPEP
gene id: 9615:ENPEP
uniprot id: A0A8I3P176
uniprot id: A0A8P0NDK5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9615:HPGD
gene id: 9615:HPGD
uniprot id: A0A8C0NXZ1
uniprot id: E2QX67
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:SBK2
gene id: 9615:SBK2
uniprot id: A0A8C0QPZ6
uniprot id: A0A8I3RQZ0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:SRF
gene id: 9615:SRF
uniprot id: A0A8C0QNN0
uniprot id: A0A8I3RW30
names: Subcellular Location Annotation
messages: Nucleus

9615:CTDP1
gene id: 9615:CTDP1
uniprot id: A0A8C0RAV2
uniprot id: A0A8I3MFD6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

9615:DMC1
gene id: 9615:DMC1
uniprot id: A0A8C0Q9Z7
uniprot id: A0A8I3S7E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

9615:BIRC2
gene id: 9615:BIRC2
uniprot id: A0A8P0PGJ4
uniprot id: Q38JA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9615:H2AC20
gene id: 9615:H2AC20
uniprot id: A0A8C0QMZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:ZDHHC6
gene id: 9615:ZDHHC6
uniprot id: A0A8C0NVK4
uniprot id: A0A8I3SCG3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:SCNN1G
gene id: 9615:SCNN1G
uniprot id: A0A8C0RNX3
names: Subcellular Location Annotation
messages: Membrane

9615:SLC6A1
gene id: 9615:SLC6A1
uniprot id: A0A8C0MJH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9615:TOP3A
gene id: 9615:TOP3A
uniprot id: A0A8C0LYC9
uniprot id: A0A8I3PC45
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9615:PPP2R3C
gene id: 9615:PPP2R3C
uniprot id: A0A8P0SHX8
names: Subcellular Location Annotation
messages: Nucleus

9615:DHX8
gene id: 9615:DHX8
uniprot id: A0A8C0LYS1
names: Subcellular Location Annotation
messages: Nucleus

9615:RBFOX1
gene id: 9615:RBFOX1
uniprot id: A0A8I3NYU8
uniprot id: A0A8P0P7T1
names: Subcellular Location Annotation
messages: Nucleus

9615:IRX5
gene id: 9615:IRX5
uniprot id: A0A8I3MH94
uniprot id: A0A8P0P4E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9615:CFAP126
gene id: 9615:CFAP126
uniprot id: A0A8I3S6W2
uniprot id: A0A8P0NEU6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9615:PAX5
gene id: 9615:PAX5
uniprot id: A0A8C0MG08
uniprot id: A0A8I3NE25
uniprot id: A0A8I3P001
uniprot id: A0A8P0PGX2
names: Subcellular Location Annotation
messages: Nucleus

9615:CMA1
gene id: 9615:CMA1
uniprot id: P21842
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Granzyme subfamily.
messages: Cytoplasmic granule
messages: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
messages: Secreted

9615:BRD2
gene id: 9615:BRD2
uniprot id: Q5TJG6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis (By similarity).
messages: Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13' (By similarity).
messages: Nucleus

9615:LOC486445
gene id: 9615:LOC486445
uniprot id: A0A8P0SWZ4
names: Similarity
messages: Belongs to the RIMBP family.

9615:NDUFS8
gene id: 9615:NDUFS8
uniprot id: A0A8C0PCF8
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

9615:HSPB6
gene id: 9615:HSPB6
uniprot id: A0A8I3RRG1
uniprot id: A0A8P0TTI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA.
messages: Nucleus

9615:SPO11
gene id: 9615:SPO11
uniprot id: A0A8C0RTS7
uniprot id: A0A8C0SWK4
uniprot id: A0A8I3Q8P2
uniprot id: A0A8I3QL01
names: Similarity
messages: Belongs to the TOP6A family.

9615:YIPF4
gene id: 9615:YIPF4
uniprot id: A0A8C0NKT6
uniprot id: A0A8I3RXF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:ITPRIPL2
gene id: 9615:ITPRIPL2
uniprot id: A0A8C0RVC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9615:HDX
gene id: 9615:HDX
uniprot id: A0A8C0YT96
names: Subcellular Location Annotation
messages: Nucleus

9615:GSTO2
gene id: 9615:GSTO2
uniprot id: A0A8C0TQC5
uniprot id: A0A8C0TQR0
uniprot id: A0A8I3PJI7
uniprot id: A0A8I3S3X7
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9615:MFNG
gene id: 9615:MFNG
uniprot id: A0A8I3NG67
uniprot id: A0A8P0PM89
names: Subcellular Location Annotation
messages: Membrane

9615:BUD13
gene id: 9615:BUD13
uniprot id: A0A8C0RWF8
uniprot id: A0A8I3MWA9
names: Similarity
messages: Belongs to the CWC26 family.

9615:UGDH
gene id: 9615:UGDH
uniprot id: A0A8C0MED8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

9615:FAM118B
gene id: 9615:FAM118B
uniprot id: A0A8C0YZS8
uniprot id: A0A8I3NEN3
names: Similarity
messages: Belongs to the FAM118 family.

9615:PSMB9
gene id: 9615:PSMB9
uniprot id: A0A8C0T7K4
uniprot id: Q5W412
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9615:ARSL
gene id: 9615:ARSL
uniprot id: Q32KI1
names: Similarity
messages: Belongs to the sulfatase family.

9615:MTMR7
gene id: 9615:MTMR7
uniprot id: A0A8C0RZK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9615:SLC9A3R2
gene id: 9615:SLC9A3R2
uniprot id: A0A8C0LVM1
uniprot id: F1Q039
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

9615:CREBBP
gene id: 9615:CREBBP
uniprot id: A0A8C0SS06
names: Subcellular Location Annotation
messages: Cytoplasm

9615:PRKCH
gene id: 9615:PRKCH
uniprot id: A0A8C0PJV6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9615:AMIGO1
gene id: 9615:AMIGO1
uniprot id: A0A8C0N4Z3
uniprot id: A0A8I3MLU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9615:GLRX
gene id: 9615:GLRX
uniprot id: A0A8C0NAE1
uniprot id: A0A8I3NFC4
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9615:HTR1D
gene id: 9615:HTR1D
uniprot id: P11614
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
messages: Homodimer. Heterodimer with HTR1B (By similarity).

9615:IL10RB
gene id: 9615:IL10RB
uniprot id: A0A8P0ST71
uniprot id: F1PS12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

9615:NDUFS5
gene id: 9615:NDUFS5
uniprot id: A0A8C0RXV3
uniprot id: A0A8I3Q2Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9615:QTRT1
gene id: 9615:QTRT1
uniprot id: A0A8C0RMP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane

9615:ARL2BP
gene id: 9615:ARL2BP
uniprot id: A0A8C0SBT8
uniprot id: A0A8I3MQR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9615:CDC42EP3
gene id: 9615:CDC42EP3
uniprot id: A0A8I3P789
uniprot id: A0A8P0NLY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9615:EHD1
gene id: 9615:EHD1
uniprot id: A0A8I3Q0J5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9615:HPS3
gene id: 9615:HPS3
uniprot id: A0A8C0MM68
uniprot id: A0A8C0S4K0
uniprot id: A0A8I3PDG5
uniprot id: A0A8I3S3J8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

9615:SEMA3A
gene id: 9615:SEMA3A
uniprot id: A0A8C0RG27
uniprot id: A0A8I3PUB8
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:GRB2
gene id: 9615:GRB2
uniprot id: A0A8C0M7T4
uniprot id: A0A8I3PT69
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9615:ZNF331
gene id: 9615:ZNF331
uniprot id: Q6JLC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation. May play a role in spermatogenesis (By similarity).
messages: Nucleus

9615:LOC482174
gene id: 9615:LOC482174
uniprot id: A0A8C0PKT0
uniprot id: A0A8I3N4R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9615:TAF1B
gene id: 9615:TAF1B
uniprot id: A0A8C0RD09
uniprot id: A0A8I3PUY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

9615:HSD17B13
gene id: 9615:HSD17B13
uniprot id: A0A8C0PP93
uniprot id: A0A8I3RYU0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:TNNI3
gene id: 9615:TNNI3
uniprot id: Q8MKD5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the troponin I family.
messages: Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1 (By similarity).
messages: Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-32. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylated at Ser-43 and Ser-45 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity).
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9615:HRH1
gene id: 9615:HRH1
uniprot id: A0A8C0Z543
uniprot id: A0A8I3MSX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:KIF7
gene id: 9615:KIF7
uniprot id: A0A8P0NDZ8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:PARPBP
gene id: 9615:PARPBP
uniprot id: A0A8C0N4J4
uniprot id: A0A8I3RWL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9615:STK10
gene id: 9615:STK10
uniprot id: A0A8C0PY59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cell membrane

9615:NR1H2
gene id: 9615:NR1H2
uniprot id: A0A8C0SEE4
uniprot id: A0A8I3NW80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9615:PKHD1
gene id: 9615:PKHD1
uniprot id: E2RK30
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Interacts with CAMLG. Interacts with PKD2. Interacts (via CST) with ARF4; this interaction allows an efficient PKHD1 trafficking to the cilium. Interacts (via CST) with RAB8A; this interaction controls trafficking through the endomembrane systeme and to the cilium. Interacts (via CST) with TULP3; this interaction allows PKHD1 trafficking to the cilium.
messages: N-glycosylated.
messages: Nucleus
messages: Palmitoylated. Palmitoylation facilitates the trafficking to the cilia and membrane targeting.
messages: Promotes ciliogenesis in renal epithelial cells and therefore participates in the tubules formation and/ or ensures the maintenance of the architecture of the lumen of the kidney (By similarity). Has an impact on cellular symmetry by ensuring correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly and by maintaining oriented cell division (OCD) during tubular elongation through planar cell polarity (PCP) pathway (By similarity). During epithelial cell morphogenesis regulates also cell-cell and cell-matrix adhesion and participates in cell motility (PubMed:32698519, PubMed:31398719). Promotes cell-cell contact through the positive regulation of PTK2 kinase activity leading to either positive regulation of epithelial cell proliferation through the HRAS/RAF1 pathways, or negative regulation of apoptosis through the PDK1/AKT1 pathway (By similarity). May act in collecting-duct and biliary differentiation (By similarity). May participate in the regulation of the cholangiocytes proliferation and the CCN2 production in an CXCL8-dependent manner (By similarity).
messages: Secreted
messages: Several proteolytic cleavages occur within the extracellular domain, whereas at least one cleavage occurs within the cytoplasmic domain. Cleaved by a probable proprotein convertase which produces an extracellular domain (polyductin extracellular domain, (PECD)) and a C-terminal fragment (polyductin transmembrane fragment (PTM)) which are tethered together by disulfide bonds. This extracellular domain (PECD) is then shed from the primary cilium by activation of a member of the ADAM metalloproteinase disintegrins family, resulting in concomitant release of an intra-cellular C-terminal fragment (ICD) via a gamma-secretase-dependent process. The proteolytic cleavage of the C-terminal intracellular fragment (ICD) is controlled by cytosolic calcium concentration and activation of PKC.
messages: centromere
messages: cilium
messages: cilium basal body
messages: extracellular exosome
messages: spindle

9615:CTNNA3
gene id: 9615:CTNNA3
uniprot id: A0A8C0MK57
uniprot id: A0A8I3MHI2
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9615:WDR3
gene id: 9615:WDR3
uniprot id: A0A8P0SET5
names: Subcellular Location Annotation
messages: nucleolus

9615:PSD
gene id: 9615:PSD
uniprot id: A0A8C0TI68
uniprot id: A0A8I3PZ07
names: Subcellular Location Annotation
messages: Membrane
messages: ruffle membrane

9615:CHD7
gene id: 9615:CHD7
uniprot id: A0A8C0SYB8
uniprot id: A0A8I3PXJ5
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9615:SEPTIN1
gene id: 9615:SEPTIN1
uniprot id: A0A8C0SKS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9615:MSRA
gene id: 9615:MSRA
uniprot id: A0A8I3PK74
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

9615:GPHB5
gene id: 9615:GPHB5
uniprot id: A0A0F7RQS3
uniprot id: A0A8C0QC57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9615:PRRT1
gene id: 9615:PRRT1
uniprot id: A0A8C0NNP5
uniprot id: A0A8I3RY99
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9615:RPL19
gene id: 9615:RPL19
uniprot id: D0VWQ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Citrullinated by PADI4.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9615:ATP2B3
gene id: 9615:ATP2B3
uniprot id: A0A8C0SWG8
uniprot id: A0A8I3PJ46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:VPS35
gene id: 9615:VPS35
uniprot id: A0A8C0NC57
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9615:SDHAF1
gene id: 9615:SDHAF1
uniprot id: A0A8C0MPU1
uniprot id: A0A8I3MI93
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

9615:VPS11
gene id: 9615:VPS11
uniprot id: A0A8C0MA69
uniprot id: A0A8I3MLR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9615:DSC1
gene id: 9615:DSC1
uniprot id: A0A8C0LWT5
uniprot id: A0A8I3NU71
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9615:MRPL2
gene id: 9615:MRPL2
uniprot id: A0A8C0NAS9
uniprot id: A0A8I3NI35
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9615:ATP8A2
gene id: 9615:ATP8A2
uniprot id: A0A8I3P728
uniprot id: A0A8P0SC99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:YPEL1
gene id: 9615:YPEL1
uniprot id: A0A8C0PK52
names: Similarity
messages: Belongs to the yippee family.

9615:PEX12
gene id: 9615:PEX12
uniprot id: A0A8C0NU61
uniprot id: A0A8I3N3I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.
messages: Membrane
messages: Peroxisome membrane

9615:PMPCA
gene id: 9615:PMPCA
uniprot id: A0A8I3NCS8
uniprot id: A0A8P0SNI6
names: Similarity
messages: Belongs to the peptidase M16 family.

9615:GALNS
gene id: 9615:GALNS
uniprot id: Q32KH5
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Homodimer.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:YWHAQ
gene id: 9615:YWHAQ
uniprot id: A0A8C0MGJ0
uniprot id: A0A8I3PQU8
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
messages: Belongs to the 14-3-3 family.

9615:PWWP3A
gene id: 9615:PWWP3A
uniprot id: A0A8C0QH00
uniprot id: A0A8I3NM45
names: Similarity
messages: Belongs to the PWWP3A family.

9615:HNF1B
gene id: 9615:HNF1B
uniprot id: A0A8C0P2E8
uniprot id: A0A8I3N7U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9615:MYORG
gene id: 9615:MYORG
uniprot id: A0A8I3PEB5
uniprot id: A0A8P0PR66
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9615:SLC22A5
gene id: 9615:SLC22A5
uniprot id: A0A8C0N0F2
uniprot id: A0A8I3NDB5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9615:RPL18
gene id: 9615:RPL18
uniprot id: D0VWQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9615:TTYH1
gene id: 9615:TTYH1
uniprot id: A0A8C0M3M7
uniprot id: A0A8C0PJT8
uniprot id: A0A8I3MKK2
uniprot id: A0A8I3MMD8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable chloride channel.

9615:THBD
gene id: 9615:THBD
uniprot id: Q5W7P8
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in lung, liver, spleen, kidney, pancreas and lymph node. Low expression in heart, cerebrum, urinary bladder and uterus.
messages: Interacts with ITGAL, ITGAM and ITGB2.
messages: Membrane
messages: N-glycosylated.
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
messages: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated (By similarity).

9615:TMEM218
gene id: 9615:TMEM218
uniprot id: A0A8C0NDU3
uniprot id: A0A8I3RYG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9615:LARS1
gene id: 9615:LARS1
uniprot id: A0A8C0QHF9
uniprot id: A0A8I3PDH1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:PLA2G1B
gene id: 9615:PLA2G1B
uniprot id: P06596
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Monomer or homodimer.
messages: Secreted
messages: Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (By similarity). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).

9615:RPS8
gene id: 9615:RPS8
uniprot id: A0A8C0NFR2
uniprot id: A0A8I3PPA9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

9615:SSBP1
gene id: 9615:SSBP1
uniprot id: A0A8C0PG91
uniprot id: E2RST4
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9615:CEACAM28
gene id: 9615:CEACAM28
uniprot id: A1YV64
names: Subcellular Location Annotation
messages: Cell membrane

9615:SERF2
gene id: 9615:SERF2
uniprot id: A0A8C0Z350
uniprot id: A0A8I3SA20
names: Similarity
messages: Belongs to the SERF family.

9615:DOK1
gene id: 9615:DOK1
uniprot id: A0A8P0NAJ2
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9615:VPS29
gene id: 9615:VPS29
uniprot id: A0A8C0P8J0
uniprot id: A0A8C0TAU4
uniprot id: A0A8I3QNJ1
uniprot id: A0A8I3S6P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9615:PSMB3
gene id: 9615:PSMB3
uniprot id: A0A8C0M3N7
uniprot id: A0A8I3RXV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9615:ANKS4B
gene id: 9615:ANKS4B
uniprot id: A0A8C0MKZ6
uniprot id: A0A8I3MV48
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9615:HNF4A
gene id: 9615:HNF4A
uniprot id: A0A8C0N5R1
uniprot id: A0A8I3NQX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:XKR9
gene id: 9615:XKR9
uniprot id: A0A8I3SA41
uniprot id: A0A8P0NMV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9615:CTC1
gene id: 9615:CTC1
uniprot id: A0A8C0LZW7
uniprot id: A0A8I3QGR3
uniprot id: A0A8I3QH00
uniprot id: A0A8P0T541
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9615:TMEM159
gene id: 9615:TMEM159
uniprot id: A0A8C0SM89
uniprot id: A0A8I3N569
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9615:AP3S1
gene id: 9615:AP3S1
uniprot id: A0A8C0PJ62
uniprot id: A0A8C0PL06
uniprot id: A0A8I3MNW8
uniprot id: A0A8I3MYR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9615:SLC26A9
gene id: 9615:SLC26A9
uniprot id: A0A8C0MKK0
uniprot id: A0A8I3QEK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane.
messages: Membrane

9615:OR5H12
gene id: 9615:OR5H12
uniprot id: A0A8I3S1Q1
uniprot id: A0A8P0NZI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:UHRF2
gene id: 9615:UHRF2
uniprot id: A0A8C0S7W7
uniprot id: A0A8I3PVP0
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

9615:LNPEP
gene id: 9615:LNPEP
uniprot id: A0A8C0NNI0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9615:DEFB125
gene id: 9615:DEFB125
uniprot id: A0A8C0TD24
uniprot id: Q30KS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:SGSH
gene id: 9615:SGSH
uniprot id: A0A8C0PTX5
uniprot id: Q9GJU7
names: Similarity
messages: Belongs to the sulfatase family.

9615:SS18
gene id: 9615:SS18
uniprot id: A0A8C0SS18
uniprot id: A0A8C0ST09
uniprot id: A0A8I3NCX9
uniprot id: A0A8I3NQC6
uniprot id: A0A8I3RXA5
uniprot id: A0A8P0TTC9
names: Similarity
messages: Belongs to the SS18 family.

9615:NEUROD6
gene id: 9615:NEUROD6
uniprot id: A0A8C0RFZ1
uniprot id: A0A8I3S2E3
names: Subcellular Location Annotation
messages: Nucleus

9615:PHTF2
gene id: 9615:PHTF2
uniprot id: A0A8C0N6I7
uniprot id: A0A8I3PUC6
names: Subcellular Location Annotation
messages: Membrane

9615:KCNV2
gene id: 9615:KCNV2
uniprot id: A0A8C0N9T6
uniprot id: A0A8I3MKX7
names: Subcellular Location Annotation
messages: Membrane

9615:GSG1L
gene id: 9615:GSG1L
uniprot id: A0A8C0PZU2
uniprot id: A0A8I3MJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9615:MPZ
gene id: 9615:MPZ
uniprot id: A0A8I3Q1X6
uniprot id: A0A8P0NET5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myelin P0 protein family.
messages: Cell membrane
messages: Homodimer and homotetramer.
messages: Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
messages: Membrane

9615:AGPAT2
gene id: 9615:AGPAT2
uniprot id: A0A8I3MT53
uniprot id: A0A8P0NL10
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9615:SLC24A2
gene id: 9615:SLC24A2
uniprot id: A0A8C0RD99
uniprot id: A0A8C0TAN8
uniprot id: A0A8I3NPM6
uniprot id: A0A8I3S115
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9615:LOC106559170
gene id: 9615:LOC106559170
uniprot id: A0A8C0S668
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9615:FZD3
gene id: 9615:FZD3
uniprot id: A0A8C0Z036
uniprot id: A0A8I3PFW0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:DDX58
gene id: 9615:DDX58
uniprot id: A0A8C0QM78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9615:ZNF444
gene id: 9615:ZNF444
uniprot id: A0A8C0RAJ6
uniprot id: A0A8I3MAC5
names: Subcellular Location Annotation
messages: Nucleus

9615:TANGO6
gene id: 9615:TANGO6
uniprot id: A0A8C0NF40
names: Similarity
messages: Belongs to the Tango6 family.

9615:HMOX1
gene id: 9615:HMOX1
uniprot id: A0A8P0N4U0
uniprot id: Q6Q2K4
names: Similarity
messages: Belongs to the heme oxygenase family.

9615:HS3ST3A1
gene id: 9615:HS3ST3A1
uniprot id: A0A8C0TAA7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:NCOA1
gene id: 9615:NCOA1
uniprot id: A0A8C0NNK5
uniprot id: A0A8P0N6V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9615:GTF2H5
gene id: 9615:GTF2H5
uniprot id: A0A8C0TG13
uniprot id: A0A8I3MY59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

9615:ANXA1
gene id: 9615:ANXA1
uniprot id: A0A8C0PB64
uniprot id: A0A8I3M9P4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9615:ELOC
gene id: 9615:ELOC
uniprot id: A0A8C0SXC4
uniprot id: A0A8I3PYQ7
names: Similarity
messages: Belongs to the SKP1 family.

9615:PTPRG
gene id: 9615:PTPRG
uniprot id: A0A8C0NLQ0
uniprot id: A0A8C0NYF7
uniprot id: A0A8I3NWQ4
uniprot id: A0A8I3NZJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9615:PRPS1
gene id: 9615:PRPS1
uniprot id: A0A8C0PE32
uniprot id: A0A8I3P9J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9615:ATP11C
gene id: 9615:ATP11C
uniprot id: A0A8C0NXS3
uniprot id: A0A8C0P2R1
uniprot id: A0A8C0SGL2
uniprot id: A0A8I3SCM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:AAMP
gene id: 9615:AAMP
uniprot id: Q7YR70
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway (By similarity).

9615:RAB3D
gene id: 9615:RAB3D
uniprot id: A0A8C0SV76
uniprot id: A0A8I3P6T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9615:GDF15
gene id: 9615:GDF15
uniprot id: A0A8C0TNP6
names: Similarity
messages: Belongs to the TGF-beta family.

9615:SCN1B
gene id: 9615:SCN1B
uniprot id: Q4PPC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
messages: Cell membrane
messages: Cell projection
messages: Component of a voltage-sensitive sodium channel complex that consists of a pore-forming alpha subunit and one or more regulatory beta subunits. Interacts with SCN4A. Interacts with NFASC. Interacts with SCN10A (By similarity). Interacts with SCN1A. Interacts with SCN3A. Interacts with SCN5A. Interacts with SCN8A (By similarity).
messages: Perikaryon
messages: Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
messages: axon

9615:PCID2
gene id: 9615:PCID2
uniprot id: A0A8C0S4B1
uniprot id: A0A8C0S4J5
uniprot id: A0A8I3S898
names: Similarity
messages: Belongs to the CSN12 family.

9615:LOC106560171
gene id: 9615:LOC106560171
uniprot id: A0A8C0RGA8
uniprot id: A0A8I3NGA3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9615:STMN4
gene id: 9615:STMN4
uniprot id: A0A8C0P9P3
uniprot id: A0A8C0RSC9
uniprot id: A0A8I3NHQ3
uniprot id: A0A8I3NM27
uniprot id: A0A8I3NPJ8
uniprot id: A0A8P0NAY3
names: Similarity
messages: Belongs to the stathmin family.

9615:DGKA
gene id: 9615:DGKA
uniprot id: A0A8C0Q5Y6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Monomer.

9615:CYB5R2
gene id: 9615:CYB5R2
uniprot id: A0A8I3RYD7
uniprot id: A0A8P0N972
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9615:TRIM32
gene id: 9615:TRIM32
uniprot id: A0A8C0S271
uniprot id: A0A8I3NMV1
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9615:CENPS
gene id: 9615:CENPS
uniprot id: A0A8C0NTG5
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

9615:SLC35B4
gene id: 9615:SLC35B4
uniprot id: D6CJI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9615:CPNE9
gene id: 9615:CPNE9
uniprot id: A0A8C0MPE5
names: Similarity
messages: Belongs to the copine family.

9615:MAT2A
gene id: 9615:MAT2A
uniprot id: A0A8C0N4M9
uniprot id: A0A8I3NU09
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9615:RSPO1
gene id: 9615:RSPO1
uniprot id: A0A8C0QCP5
uniprot id: B4XH82
names: Similarity
messages: Belongs to the R-spondin family.

9615:B3GAT3
gene id: 9615:B3GAT3
uniprot id: A0A8C0T8N5
uniprot id: A0A8I3RWN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:CRBN
gene id: 9615:CRBN
uniprot id: A0A8C0RYL7
uniprot id: A0A8I3NIQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9615:BPNT2
gene id: 9615:BPNT2
uniprot id: A0A8C0NQZ6
uniprot id: A0A8I3PTD3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9615:OR4P4
gene id: 9615:OR4P4
uniprot id: A0A8C0MDC9
uniprot id: A0A8I3NHW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:FGF16
gene id: 9615:FGF16
uniprot id: A0A8C0SP20
uniprot id: J9P8K0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:VAT1
gene id: 9615:VAT1
uniprot id: A0A8C0LX65
uniprot id: A0A8I3RT77
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9615:EIF2B4
gene id: 9615:EIF2B4
uniprot id: A0A8C0S5J2
uniprot id: A0A8I3N5P8
uniprot id: A0A8I3N619
uniprot id: A0A8P0NLU9
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9615:EIF2S1
gene id: 9615:EIF2S1
uniprot id: A0A8C0RLY3
uniprot id: A0A8I3MV19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9615:RCAN3
gene id: 9615:RCAN3
uniprot id: A0A8C0LVB8
uniprot id: A0A8C0PRA7
uniprot id: A0A8I3NHF5
uniprot id: A0A8P0PPS2
names: Similarity
messages: Belongs to the RCAN family.

9615:RAD51D
gene id: 9615:RAD51D
uniprot id: A0A8I3NE17
uniprot id: A0A8P0T8Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

9615:CCDC65
gene id: 9615:CCDC65
uniprot id: A0A8C0P9G0
uniprot id: A0A8I3PVD3
names: Subcellular Location Annotation
messages: flagellum axoneme

9615:NKRF
gene id: 9615:NKRF
uniprot id: A0A8C0SLH9
uniprot id: A0A8I3PLB9
names: Similarity
messages: Belongs to the CARF family.

9615:FNIP2
gene id: 9615:FNIP2
uniprot id: A0A8P0TG57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9615:XPO4
gene id: 9615:XPO4
uniprot id: A0A8I3P888
uniprot id: A0A8I3PGU4
uniprot id: A0A8P0SVJ5
uniprot id: A0A8P0TJA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

9615:C5H1orf174
gene id: 9615:C5H1orf174
uniprot id: A0A8C0M2W8
uniprot id: A0A8I3P6R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9615:SLC25A3
gene id: 9615:SLC25A3
uniprot id: A0A8C0P0S3
uniprot id: A0A8C0RPF9
uniprot id: A0A8I3Q027
uniprot id: A0A8I3Q073
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9615:PGF
gene id: 9615:PGF
uniprot id: A0A8C0NVC7
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9615:DYNC1I1
gene id: 9615:DYNC1I1
uniprot id: A0A8C0RNB8
uniprot id: A0A8C0SKN6
uniprot id: A0A8I3S4U5
uniprot id: A0A8I3S4X0
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9615:ARSI
gene id: 9615:ARSI
uniprot id: A0A8C0S4K7
uniprot id: A0A8I3N2H8
uniprot id: Q32KH7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts.
messages: Endoplasmic reticulum
messages: Secreted
messages: The oxidation of Cys-94 residue to 3-oxoalanine (also known as C(alpha)-formylglycine) by SUMF1/Sulfatase-modifying factor 1, seems critical for catalytic activity.

9615:FGF4
gene id: 9615:FGF4
uniprot id: A0A8C0QMH2
uniprot id: J9P3I7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:SERINC5
gene id: 9615:SERINC5
uniprot id: A0A8C0Q3V3
uniprot id: A0A8I3RT14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9615:DNAJB14
gene id: 9615:DNAJB14
uniprot id: A0A8C0RQR0
uniprot id: A0A8I3PXR8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:DNTTIP2
gene id: 9615:DNTTIP2
uniprot id: A0A8C0RHW4
uniprot id: A0A8I3NV63
names: Subcellular Location Annotation
messages: nucleolus

9615:PHETA2
gene id: 9615:PHETA2
uniprot id: A0A8C0SRM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9615:PPM1B
gene id: 9615:PPM1B
uniprot id: A0A8C0N3R5
uniprot id: A0A8I3PZS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9615:CALR3
gene id: 9615:CALR3
uniprot id: A0A8C0P9A6
uniprot id: A0A8I3Q2D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9615:NBR1
gene id: 9615:NBR1
uniprot id: A0A8P0SWN0
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9615:IGFBP1
gene id: 9615:IGFBP1
uniprot id: A0A8C0MZD6
uniprot id: A0A8I3NJH1
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:KCNJ12
gene id: 9615:KCNJ12
uniprot id: A0A8C0MAF6
uniprot id: F6KIF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
messages: Cell membrane
messages: Membrane

9615:OR8U8
gene id: 9615:OR8U8
uniprot id: A0A8C0SQZ4
uniprot id: A0A8I3RT47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:TPRG1
gene id: 9615:TPRG1
uniprot id: A0A8P0TSA7
names: Similarity
messages: Belongs to the TPRG1 family.

9615:MYOG
gene id: 9615:MYOG
uniprot id: A0A8C0MCM5
uniprot id: A0A8I3NSP2
names: Subcellular Location Annotation
messages: Nucleus

9615:FAM151A
gene id: 9615:FAM151A
uniprot id: A0A8C0M546
uniprot id: D0VE84
names: Similarity
messages: Belongs to the FAM151 family.

9615:WDR82
gene id: 9615:WDR82
uniprot id: A0A8C0TCN1
uniprot id: A0A8I3QC53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9615:PDHX
gene id: 9615:PDHX
uniprot id: A0A8C0YZW1
uniprot id: A0A8I3S3H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9615:CDC45
gene id: 9615:CDC45
uniprot id: A0A8C0NXS2
uniprot id: A0A8I3Q3M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9615:GNG4
gene id: 9615:GNG4
uniprot id: A0A8C0PRI2
uniprot id: A0A8I3ML62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:CEACAM23
gene id: 9615:CEACAM23
uniprot id: A1YV60
names: Subcellular Location Annotation
messages: Cell membrane

9615:PDCD4
gene id: 9615:PDCD4
uniprot id: A0A8C0T5S2
names: Similarity
messages: Belongs to the PDCD4 family.

9615:UTP11
gene id: 9615:UTP11
uniprot id: A0A8C0RXU2
uniprot id: A0A8I3Q8Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9615:OR10K2
gene id: 9615:OR10K2
uniprot id: A0A8C0NJ80
uniprot id: E2R0N4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:H2AC17
gene id: 9615:H2AC17
uniprot id: A0A5F4CIE3
uniprot id: A0A8C0NV55
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:BCO2
gene id: 9615:BCO2
uniprot id: A0A8P0TIU0
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

9615:PDE6D
gene id: 9615:PDE6D
uniprot id: Q9XT54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains (PDE6A and PDE6B) and two inhibitory chains (gamma); has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane (By similarity). Interacts with prenylated GRK1 and GRK7 (By similarity). Interacts with prenylated INPP5E (By similarity). Interacts with prenylated Ras family members, including HRAS, KRAS, NRAS, RAP2A, RAP2C and RHEB (By similarity). Interacts with RAB13 (prenylated form); dissociates RAB13 from membranes (By similarity). Interacts with RPGR (By similarity). Interacts with ARL2 (By similarity). Interacts with ARL3; the interaction occurs specifically with the GTP-bound form of ARL3 (By similarity). Interaction with ARL2 and ARL3 promotes release of farnesylated cargo proteins (By similarity).
messages: Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).
messages: Retina.
messages: cilium basal body
messages: cytosol

9615:LOC100684983
gene id: 9615:LOC100684983
uniprot id: A0A8C0MRP4
uniprot id: A0A8I3P8E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:MRM1
gene id: 9615:MRM1
uniprot id: A0A8C0RSE5
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

9615:ERAP1
gene id: 9615:ERAP1
uniprot id: A0A8P0TLH2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9615:SMIM8
gene id: 9615:SMIM8
uniprot id: A0A8I3RU80
uniprot id: A0A8P0TJF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9615:MAP6
gene id: 9615:MAP6
uniprot id: A0A8P0SAW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

9615:DDX24
gene id: 9615:DDX24
uniprot id: A0A8C0PYT6
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9615:SERPINB7
gene id: 9615:SERPINB7
uniprot id: A0A8C0RK04
uniprot id: A0A8I3N155
names: Similarity
messages: Belongs to the serpin family.

9615:TFRC
gene id: 9615:TFRC
uniprot id: Q9GLD3
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
messages: Homodimer; disulfide-linked. Binds one transferrin molecule per subunit. Interacts with SH3BP4 (By similarity). Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (By similarity).
messages: Melanosome
messages: N- and O-glycosylated, phosphorylated and palmitoylated.
messages: Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation (By similarity). Stearoylation does not affect iron uptake (By similarity).
messages: The YTRF endocytosis motif engages the clathrin-mediated endocytic machinery through adapter protein-2.

9615:BPIFC
gene id: 9615:BPIFC
uniprot id: A0A8P0NWK3
uniprot id: A0A8P0P2N4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9615:FABP7
gene id: 9615:FABP7
uniprot id: A0A8C0RH38
uniprot id: A0A8I3RVB9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9615:SOX14
gene id: 9615:SOX14
uniprot id: A0A8C0N4V0
uniprot id: A0A8I3PHG7
names: Subcellular Location Annotation
messages: Nucleus

9615:ALKBH8
gene id: 9615:ALKBH8
uniprot id: A0A8C0SHI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

9615:AP3M1
gene id: 9615:AP3M1
uniprot id: A0A8C0Q4Z8
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

9615:NKX2-1
gene id: 9615:NKX2-1
uniprot id: P43698
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NK-2 homeobox family.
messages: Nucleus
messages: Phosphorylated on serine residues.
messages: Thyroid, lung and CNS.
messages: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis.

9615:NPM1
gene id: 9615:NPM1
uniprot id: A0A8C0PRY9
uniprot id: A0A8I3MEU8
names: Similarity
messages: Belongs to the nucleoplasmin family.

9615:S100PBP
gene id: 9615:S100PBP
uniprot id: A0A8C0NIF7
uniprot id: A0A8I3MT24
uniprot id: A0A8P0NCT0
names: Subcellular Location Annotation
messages: Nucleus

9615:MED15
gene id: 9615:MED15
uniprot id: A0A8I3PI14
uniprot id: A0A8I3PQB3
uniprot id: A0A8P0NGG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:LBH
gene id: 9615:LBH
uniprot id: A0A8C0NJW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9615:SF1
gene id: 9615:SF1
uniprot id: A0A8C0MCV9
uniprot id: A0A8C0RD15
uniprot id: A0A8C0THZ8
uniprot id: A0A8C0Z4M0
uniprot id: A0A8I3Q776
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

9615:GUCA2A
gene id: 9615:GUCA2A
uniprot id: A0A8C0PMF7
uniprot id: A0A8I3P3W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9615:SAMD4B
gene id: 9615:SAMD4B
uniprot id: A0A8C0R9E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

9615:ENO3
gene id: 9615:ENO3
uniprot id: A0A8C0PRY5
uniprot id: A0A8I3MKD5
uniprot id: A0A8I3N5K2
uniprot id: A0A8P0SZR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9615:RGS4
gene id: 9615:RGS4
uniprot id: A0A8C0PAF2
uniprot id: A0A8I3PWB5
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9615:B3GALT2
gene id: 9615:B3GALT2
uniprot id: A0A8C0S8H1
uniprot id: A0A8I3PNT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:DHCR7
gene id: 9615:DHCR7
uniprot id: A0A8C0PLQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9615:AASDHPPT
gene id: 9615:AASDHPPT
uniprot id: A0A8C0MMF3
uniprot id: A0A8I3MTD3
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

9615:CALHM1
gene id: 9615:CALHM1
uniprot id: A0A8C0PNB1
uniprot id: A0A8I3Q1Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9615:MIP
gene id: 9615:MIP
uniprot id: A2IBY8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side (By similarity).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Fatty acylated at Met-1 and Lys-238. The acyl modifications, in decreasing order of ion abundance, are: oleoyl (C18:1) > palmitoyl (C16:0) > stearoyl (C18:0) > eicosenoyl (C20:1) > dihomo-gamma-linolenoyl (C20:3) > palmitoleoyl (C16:1) > eicosadienoyl (C20:2).
messages: Homotetramer. Homooctamer formed by head-to-head interaction between homotetramers from adjoining membranes. Interacts with CALM; one CALM molecule interacts with the cytoplasmic domains of two aquaporins, leading to channel closure. Interacts (via C-terminus) with BFSP1 (via C-terminus) in aged lens fiber cells (By similarity).
messages: Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes (By similarity).
messages: Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity).
messages: gap junction

9615:PGLS
gene id: 9615:PGLS
uniprot id: A0A8C0P174
uniprot id: A0A8I3SAK1
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

9615:EIF3I
gene id: 9615:EIF3I
uniprot id: A0A8I3MMU7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9615:VAX1
gene id: 9615:VAX1
uniprot id: A0A8C0TX53
uniprot id: A0A8I3QCK3
names: Subcellular Location Annotation
messages: Nucleus

9615:UBE2F
gene id: 9615:UBE2F
uniprot id: A0A8I3Q1K9
uniprot id: A0A8P0P0C8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:VMA21
gene id: 9615:VMA21
uniprot id: A0A8C0SL72
uniprot id: A0A8I3PIV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

9615:FABP4
gene id: 9615:FABP4
uniprot id: A0A8C0T7B6
uniprot id: A0A8I3NQN1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9615:LDB2
gene id: 9615:LDB2
uniprot id: A0A8C0M2G7
names: Similarity
messages: Belongs to the LDB family.

9615:H2AC8
gene id: 9615:H2AC8
uniprot id: A0A8I3S9E1
uniprot id: A0A8P0SUN4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:JAG1
gene id: 9615:JAG1
uniprot id: A0A8C0NXU1
uniprot id: A0A8I3Q037
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9615:PAPPA2
gene id: 9615:PAPPA2
uniprot id: A0A8P0SIY3
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:GPR89A
gene id: 9615:GPR89A
uniprot id: A0A8C0QI31
uniprot id: A0A8I3N8Z3
uniprot id: A0A8I3RXH8
uniprot id: A0A8P0TLT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9615:ITPR3
gene id: 9615:ITPR3
uniprot id: A0A8I3S857
uniprot id: A0A8P0T6V6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9615:SOSTDC1
gene id: 9615:SOSTDC1
uniprot id: A0A8C0NXY2
uniprot id: A0A8I3N0S9
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:LOC100856765
gene id: 9615:LOC100856765
uniprot id: A0A8I3SA72
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

9615:AP1G1
gene id: 9615:AP1G1
uniprot id: A0A8C0T135
uniprot id: A0A8I3N275
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9615:FER
gene id: 9615:FER
uniprot id: Q9TTY2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell junction
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Homotrimer. Interacts with CTNND1, EGFR, FLT3, IRS1, PECAM1, PIK3R1 and PDGFR. Interacts (via SH2 domain) with CTTN. Component of a complex that contains at least FER, CTTN and PTK2/FAK1 (By similarity).
messages: Membrane
messages: Nucleus
messages: The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes.
messages: The coiled coil domains mediate homooligomerization and are required for location at microtubules.
messages: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell attachment and cell migration. Acts downstream of EGFR, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11 (By similarity).
messages: cell cortex
messages: cytoskeleton

9615:COPB1
gene id: 9615:COPB1
uniprot id: A0A8C0T686
uniprot id: A0A8I3PLJ3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9615:PRKCZ
gene id: 9615:PRKCZ
uniprot id: A0A8C0QAW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9615:SLC25A34
gene id: 9615:SLC25A34
uniprot id: A0A8C0Q6K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:MED21
gene id: 9615:MED21
uniprot id: A0A8C0Z3Q0
uniprot id: J9P8B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9615:ACAD11
gene id: 9615:ACAD11
uniprot id: A0A8C0MKN4
uniprot id: A0A8I3SCA7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9615:TM2D1
gene id: 9615:TM2D1
uniprot id: A0A8C0LUR4
names: Subcellular Location Annotation
messages: Membrane

9615:IDH3B
gene id: 9615:IDH3B
uniprot id: A0A8C0SZ51
uniprot id: A0A8C0T195
uniprot id: A0A8I3S238
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9615:KRT1
gene id: 9615:KRT1
uniprot id: Q6EIY9
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Heterotetramer of two type I and two type II keratins (By similarity). Heterodimer with KRT10 (By similarity). Two heterodimers of KRT1 and KRT10 form a heterotetramer (By similarity). Forms a heterodimer with KRT14; the interaction is more abundant in the absence of KRT5 (By similarity). Interacts with ITGB1 in the presence of RACK1 and SRC, and with RACK1 (By similarity). Interacts with C1QBP; the association represents a cell surface kininogen receptor (By similarity). Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament (By similarity).
messages: May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity).
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
messages: Undergoes deimination of some arginine residues (citrullination).

9615:LOC607692
gene id: 9615:LOC607692
uniprot id: A0A8C0NDN7
uniprot id: A0A8I3MK47
names: Subcellular Location Annotation
messages: Nucleus

9615:TMEM39B
gene id: 9615:TMEM39B
uniprot id: A0A8C0NLC5
uniprot id: A0A8I3MYL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9615:SLC9A7
gene id: 9615:SLC9A7
uniprot id: A0A8C0SS32
uniprot id: A0A8C0SST7
uniprot id: A0A8I3Q062
uniprot id: A0A8I3Q7A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Recycling endosome membrane

9615:GSTZ1
gene id: 9615:GSTZ1
uniprot id: A0A8C0SXG5
uniprot id: A0A8C0Z0F0
uniprot id: A0A8I3MVI4
uniprot id: A0A8I3N003
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9615:PIP
gene id: 9615:PIP
uniprot id: A0A8C0RYL6
names: Similarity
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1.

9615:KPNA2
gene id: 9615:KPNA2
uniprot id: A0A8C0NGB8
uniprot id: A0A8I3PRA9
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9615:P2RX6
gene id: 9615:P2RX6
uniprot id: A0A8C0TCB2
uniprot id: A0A8I3S3K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9615:GALNT6
gene id: 9615:GALNT6
uniprot id: A0A8C0PF08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:SULF1
gene id: 9615:SULF1
uniprot id: Q32KH2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:NDUFB2
gene id: 9615:NDUFB2
uniprot id: A0A8C0MHW9
uniprot id: A0A8I3Q8I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:TNFRSF14
gene id: 9615:TNFRSF14
uniprot id: A0A8C0RYX0
uniprot id: E2QXY8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:NTS
gene id: 9615:NTS
uniprot id: P10673
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neurotensin family.
messages: Interacts with NTSR1. Interacts with SORT1. Interacts with SORL1.
messages: Neurotensin is cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: secretory vesicle

9615:ATG9A
gene id: 9615:ATG9A
uniprot id: A0A8C0TQP7
uniprot id: A0A8I3QTY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9615:UBE2H
gene id: 9615:UBE2H
uniprot id: A0A8C0PAB4
uniprot id: A0A8I3PB35
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:EIF3J
gene id: 9615:EIF3J
uniprot id: A0A8C0NGL3
uniprot id: A0A8I3Q3R6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9615:PM20D2
gene id: 9615:PM20D2
uniprot id: A0A8C0S876
uniprot id: A0A8I3N3F7
names: Function
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus.

9615:OR4K15
gene id: 9615:OR4K15
uniprot id: A0A8C0TI08
uniprot id: A0A8I3NYI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CAPN9
gene id: 9615:CAPN9
uniprot id: A0A8C0NDL3
uniprot id: A0A8I3MDF9
names: Similarity
messages: Belongs to the peptidase C2 family.

9615:TSC22D3
gene id: 9615:TSC22D3
uniprot id: A0A8C0TGK9
uniprot id: A0A8C0TKB0
uniprot id: A0A8C0TKS8
uniprot id: A0A8I3NZ89
uniprot id: A0A8I3S078
uniprot id: A0A8I3S314
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9615:NDUFA1
gene id: 9615:NDUFA1
uniprot id: A0A8C0P913
uniprot id: A0A8I3P826
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:PKP1
gene id: 9615:PKP1
uniprot id: A0A8I3S0K7
uniprot id: A0A8P0NYX3
names: Similarity
messages: Belongs to the beta-catenin family.

9615:CAV1
gene id: 9615:CAV1
uniprot id: P33724
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer (PubMed:7568142). Interacts with BMX, BTK, GLIPR2, NOSTRIN, SNAP25 and STX1A. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with SLC7A9 (By similarity). Interacts with CTNNB1, CDH1 and JUP (PubMed:10816572). Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner (By similarity). Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation (By similarity). Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
messages: Membrane raft
messages: Phosphorylation of isoform Beta on serine residues is constitutive. Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress (By similarity).
messages: Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response.
messages: caveola
messages: trans-Golgi network

9615:GPR142
gene id: 9615:GPR142
uniprot id: A0A8C0Q811
uniprot id: F1PLR4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:GJC3
gene id: 9615:GJC3
uniprot id: A0A8I3PM88
uniprot id: A0A8P0NGL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:AMOTL2
gene id: 9615:AMOTL2
uniprot id: A0A8I3QA39
uniprot id: A0A8P0SC30
names: Similarity
messages: Belongs to the angiomotin family.

9615:GCFC2
gene id: 9615:GCFC2
uniprot id: A0A8I3NWW8
uniprot id: A0A8P0NAL8
names: Similarity
messages: Belongs to the GCF family.

9615:ILK
gene id: 9615:ILK
uniprot id: A0A8C0NGM4
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9615:FEN1
gene id: 9615:FEN1
uniprot id: A0A8C0TEX7
uniprot id: A0A8I3NJ50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Mitochondrion
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9615:MIEF1
gene id: 9615:MIEF1
uniprot id: A0A8C0NSM9
uniprot id: A0A8I3PLE3
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9615:ZDHHC20
gene id: 9615:ZDHHC20
uniprot id: A0A8C0PJ41
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:KRTDAP
gene id: 9615:KRTDAP
uniprot id: Q52MQ7
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Highly expressed in skin, but not detectable in any other tissue examined. Expression restricted to cornified/stratified epithelia and not detected in non-cornified/stratified epithelia.
messages: May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity).
messages: Secreted

9615:IDS
gene id: 9615:IDS
uniprot id: A0A8C0MNW8
uniprot id: Q32KH3
names: Similarity
messages: Belongs to the sulfatase family.

9615:KXD1
gene id: 9615:KXD1
uniprot id: A0A8C0NF04
uniprot id: A0A8I3S237
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9615:SLC51A
gene id: 9615:SLC51A
uniprot id: A0A8C0TUF0
uniprot id: A0A8I3Q2C1
names: Subcellular Location Annotation
messages: Membrane

9615:UIMC1
gene id: 9615:UIMC1
uniprot id: A0A8C0YZX9
uniprot id: A0A8I3NJJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

9615:FLVCR1
gene id: 9615:FLVCR1
uniprot id: A0A8I3MHS3
uniprot id: A0A8P0NED1
names: Subcellular Location Annotation
messages: Membrane

9615:PRCD
gene id: 9615:PRCD
uniprot id: Q00LT9
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PRCD family.
messages: Defects in PRCD are the cause of progressive rod-cone degeneration (PRCD) (PubMed:16938425). PRCD is the most widespread hereditary retinal disease leading to blindness in dogs and phenotypically is the canine counterpart of retinitis pigmentosa in humans (PubMed:16938425).
messages: Endoplasmic reticulum
messages: Expressed in retina.
messages: Golgi apparatus
messages: Interacts with RHO/rhodopsin; the interaction promotes PRCD stability.
messages: Involved in vision.
messages: Membrane
messages: Palmitoylated at Cys-2. Palmitoylation is essential for protein stability and trafficking to the photoreceptor outer segment, but does not appear to be essential for membrane localization. Probably palmitoylated by ZDHHC3.
messages: Phosphorylated.
messages: photoreceptor outer segment

9615:CLEC16A
gene id: 9615:CLEC16A
uniprot id: A0A8C0QH60
uniprot id: A0A8I3RXC4
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9615:KCNB1
gene id: 9615:KCNB1
uniprot id: A0A8C0RS07
uniprot id: A0A8I3PX68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: dendrite
messages: sarcolemma
messages: synaptosome

9615:ATM
gene id: 9615:ATM
uniprot id: B3VMJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Cytoplasmic vesicle
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks.

9615:ADGRF2
gene id: 9615:ADGRF2
uniprot id: A0A8C0YYS3
uniprot id: A0A8I3RXN9
names: Subcellular Location Annotation
messages: Membrane

9615:LDHB
gene id: 9615:LDHB
uniprot id: A0A8C0Z6I0
uniprot id: A0A8I3NY38
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9615:ASPN
gene id: 9615:ASPN
uniprot id: A0A8C0M5A4
uniprot id: A0A8I3PJ40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9615:PABPC4
gene id: 9615:PABPC4
uniprot id: A0A8C0SPY0
uniprot id: A0A8I3N997
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9615:LANCL3
gene id: 9615:LANCL3
uniprot id: A0A8C0SSG0
uniprot id: A0A8I3PMT3
names: Similarity
messages: Belongs to the LanC-like protein family.

9615:KCNMB1
gene id: 9615:KCNMB1
uniprot id: Q28266
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer (By similarity).
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity).

9615:SLC4A11
gene id: 9615:SLC4A11
uniprot id: A0A8C0SB36
uniprot id: A0A8I3NK30
uniprot id: A0A8I3NWJ8
uniprot id: A0A8P0N8Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

9615:DNAL4
gene id: 9615:DNAL4
uniprot id: A0A8C0RM40
uniprot id: A0A8I3PKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9615:CCNH
gene id: 9615:CCNH
uniprot id: A0A8C0MQJ3
uniprot id: A0A8I3P7T2
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9615:VANGL1
gene id: 9615:VANGL1
uniprot id: A0A8C0MBQ8
uniprot id: A0A8I3Q337
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9615:NDUFAF4
gene id: 9615:NDUFAF4
uniprot id: A0A8C0MRB2
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9615:SLC35A5
gene id: 9615:SLC35A5
uniprot id: A0A8I3Q7U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:NDUFB3
gene id: 9615:NDUFB3
uniprot id: A0A8C0TFQ6
uniprot id: A0A8I3S7C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9615:LOC481834
gene id: 9615:LOC481834
uniprot id: A0A8I3N459
uniprot id: A0A8P0T377
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:RRP12
gene id: 9615:RRP12
uniprot id: A0A8C0TWF1
names: Similarity
messages: Belongs to the RRP12 family.

9615:NDUFA12
gene id: 9615:NDUFA12
uniprot id: A0A8C0NJ48
uniprot id: F1PWZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:TRIM9
gene id: 9615:TRIM9
uniprot id: A0A8C0QH08
uniprot id: A0A8I3MNW9
uniprot id: A0A8P0NGF3
names: Subcellular Location Annotation
messages: cytoskeleton

9615:RDH16
gene id: 9615:RDH16
uniprot id: A0A8C0N469
uniprot id: A0A8C0S412
uniprot id: A0A8I3N0Y3
uniprot id: A0A8I3N8I3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:ARV1
gene id: 9615:ARV1
uniprot id: A0A8C0NN06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9615:RPA1
gene id: 9615:RPA1
uniprot id: A0A8C0Q875
uniprot id: A0A8I3NNF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

9615:GFOD2
gene id: 9615:GFOD2
uniprot id: A0A8C0P5Q2
uniprot id: A0A8I3RTJ3
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9615:SENP2
gene id: 9615:SENP2
uniprot id: A0A8C0MI94
uniprot id: A0A8I3NZV4
names: Similarity
messages: Belongs to the peptidase C48 family.

9615:DCTN6
gene id: 9615:DCTN6
uniprot id: A0A8C0PC42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
messages: cytoskeleton

9615:MTIF2
gene id: 9615:MTIF2
uniprot id: A0A8C0RTA4
uniprot id: A0A8I3NSU9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

9615:OSBPL9
gene id: 9615:OSBPL9
uniprot id: A0A8C0MYU5
uniprot id: A0A8C0N0U2
uniprot id: A0A8C0NA03
uniprot id: A0A8I3PDY7
uniprot id: A0A8I3S5H8
names: Similarity
messages: Belongs to the OSBP family.

9615:TAF5L
gene id: 9615:TAF5L
uniprot id: A0A8C0NE82
uniprot id: A0A8I3MKA4
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9615:TIMM21
gene id: 9615:TIMM21
uniprot id: A0A8C0PQK4
uniprot id: A0A8I3MCQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9615:ELOVL1
gene id: 9615:ELOVL1
uniprot id: A0A8C0QDN8
uniprot id: A0A8I3P5E7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9615:ADCY5
gene id: 9615:ADCY5
uniprot id: P30803
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by forskolin (PubMed:1618857, PubMed:8428899). Activated by GNAS. Activity is further increased by interaction with the G-protein beta and gamma subunit complex formed by GNB1 and GNG2 (By similarity). Is not activated by calmodulin. Inhibited by adenosine and ATP analogs. Inhibited by calcium ions, already at micromolar concentrations (PubMed:1618857). Phosphorylation by RAF1 results in its activation (By similarity).
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit (PubMed:16766715, PubMed:19243146). Is also active with manganese (in vitro) (PubMed:11087399, PubMed:16766715).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:1618857, PubMed:8428899, PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (By similarity).
messages: Cell membrane
messages: Interacts with GNAS (PubMed:9417641, PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). Interacts with GNB1 and GNG2 (By similarity). Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (By similarity). Interacts with RAF1 (By similarity).
messages: Isoform 1 is detected in heart, and at lower levels in brain (PubMed:1618857). Isoform 2 is detected in heart (PubMed:8428899).
messages: Lacks catalytic activity by itself, but can associate with isoform 1 to form active adenylyl cyclase.
messages: The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
messages: cilium

9615:ADAM12
gene id: 9615:ADAM12
uniprot id: A0A8I3PTF2
uniprot id: A0A8P0NET7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SEC23B
gene id: 9615:SEC23B
uniprot id: A0A8C0TPB4
uniprot id: A0A8C0TQ14
uniprot id: A0A8I3Q0G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9615:CYP4A37
gene id: 9615:CYP4A37
uniprot id: Q2VHZ9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:ATG4C
gene id: 9615:ATG4C
uniprot id: A0A8C0S777
uniprot id: A0A8I3MPV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9615:GABARAP
gene id: 9615:GABARAP
uniprot id: A0A8C0N0M8
uniprot id: A0A8I3P766
names: Similarity
messages: Belongs to the ATG8 family.

9615:TP53INP1
gene id: 9615:TP53INP1
uniprot id: A0A8C0Z4I6
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9615:SLC1A3
gene id: 9615:SLC1A3
uniprot id: A0A8C0QPQ6
uniprot id: Q9N280
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9615:IP6K2
gene id: 9615:IP6K2
uniprot id: A0A8C0RMR4
uniprot id: A0A8I3Q347
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9615:GIMAP2
gene id: 9615:GIMAP2
uniprot id: A0A8C0PE02
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9615:C11H5orf63
gene id: 9615:C11H5orf63
uniprot id: A0A8C0PF67
uniprot id: A0A8I3NGN4
names: Similarity
messages: Belongs to the glutaredoxin family.

9615:R3HDML
gene id: 9615:R3HDML
uniprot id: A0A8C0TKW6
uniprot id: A0A8I3NTH7
names: Similarity
messages: Belongs to the CRISP family.

9615:NUBPL
gene id: 9615:NUBPL
uniprot id: A0A8C0SJ71
uniprot id: A0A8C0SK30
uniprot id: A0A8C0SKW3
uniprot id: A0A8I3NK60
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

9615:CANX
gene id: 9615:CANX
uniprot id: P24643
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Interacts with MAPK3/ERK1 (By similarity). Interacts with KCNH2 (By similarity). Associates with ribosomes (By similarity). Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins (By similarity). Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1 (By similarity). Interacts with PPIB (PubMed:20801878). Interacts with ZNRF4 (By similarity). Interacts with SMIM22 (By similarity). Interacts with TMX2 (By similarity). Interacts with TMEM35A/NACHO and CHRNA7 (By similarity). Interacts with reticulophagy regulators RETREG2 and RETREG3 (By similarity). Interacts with DNM1L; may form part of a larger protein complex at the ER-mitochondrial interface during mitochondrial fission (By similarity). Interacts with ADAM7 (By similarity).
messages: Melanosome
messages: Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins (By similarity).
messages: Phosphorylated at Ser-565 by MAPK3/ERK1. Phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
messages: Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.

9615:TERF2IP
gene id: 9615:TERF2IP
uniprot id: A0A8P0SNQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

9615:TM7SF2
gene id: 9615:TM7SF2
uniprot id: A0A8C0Z2V7
uniprot id: A0A8I3Q0D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9615:XCR1
gene id: 9615:XCR1
uniprot id: A0A8C0T1R3
uniprot id: A0A8I3NL60
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:LOC100685924
gene id: 9615:LOC100685924
uniprot id: A0A8C0S4Y9
uniprot id: J9NZS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9615:HOXC12
gene id: 9615:HOXC12
uniprot id: A0A8C0Z324
uniprot id: A0A8I3P617
names: Subcellular Location Annotation
messages: Nucleus

9615:OR6P1
gene id: 9615:OR6P1
uniprot id: A0A8C0NLW4
uniprot id: G3FJ99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:FOXO4
gene id: 9615:FOXO4
uniprot id: A0A8C0TRE3
names: Subcellular Location Annotation
messages: Nucleus

9615:DZIP1
gene id: 9615:DZIP1
uniprot id: A0A8C0YZ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: cilium basal body

9615:BEX3
gene id: 9615:BEX3
uniprot id: A0A8C0NTC6
names: Similarity
messages: Belongs to the BEX family.

9615:PLA2G12A
gene id: 9615:PLA2G12A
uniprot id: A0A8C0TR65
uniprot id: A0A8I3Q2H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9615:NR3C1
gene id: 9615:NR3C1
uniprot id: A0A0A7KLD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

9615:SERP2
gene id: 9615:SERP2
uniprot id: A0A8C0RQV0
uniprot id: A0A8I3RVG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9615:GSKIP
gene id: 9615:GSKIP
uniprot id: A0A8C0PX38
uniprot id: A0A8I3MKY8
names: Similarity
messages: Belongs to the GSKIP family.

9615:RNF182
gene id: 9615:RNF182
uniprot id: A0A8I3PH39
uniprot id: A0A8P0TPP2
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9615:NIPAL1
gene id: 9615:NIPAL1
uniprot id: A0A8C0YS81
uniprot id: A0A8I3NNZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9615:RPL6
gene id: 9615:RPL6
uniprot id: A0A8C0TP42
uniprot id: F1Q424
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9615:HIRA
gene id: 9615:HIRA
uniprot id: A0A8C0SWZ2
uniprot id: A0A8C0T033
uniprot id: A0A8I3Q452
uniprot id: A0A8I3QW82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9615:FGF13
gene id: 9615:FGF13
uniprot id: A0A8C0S5S3
uniprot id: A0A8I3Q444
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:CDO1
gene id: 9615:CDO1
uniprot id: A0A8C0PJC2
uniprot id: A0A8I3MNS9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9615:OR52N2G
gene id: 9615:OR52N2G
uniprot id: A4GXA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SERPINA7
gene id: 9615:SERPINA7
uniprot id: A0A8C0NSU8
names: Similarity
messages: Belongs to the serpin family.

9615:LOC100855558
gene id: 9615:LOC100855558
uniprot id: A0A8C0MX81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9615:VPS41
gene id: 9615:VPS41
uniprot id: A0A8C0M6S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

9615:EEF2K
gene id: 9615:EEF2K
uniprot id: A0A8C0RMY7
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

9615:CDKN1A
gene id: 9615:CDKN1A
uniprot id: A0A7I8E886
names: Similarity
messages: Belongs to the CDI family.

9615:CXCR3
gene id: 9615:CXCR3
uniprot id: A0A8C0YUK9
uniprot id: A0A8I3NXJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

9615:EXO1
gene id: 9615:EXO1
uniprot id: A0A8P0NH35
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

9615:LOC102152612
gene id: 9615:LOC102152612
uniprot id: A0A8C0Q9N4
uniprot id: A0A8I3MY97
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9615:EPOR
gene id: 9615:EPOR
uniprot id: Q2KL21
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
messages: Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein APS, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3 and CRKL. The N-terminal SH2 domain of PTPN6 binds Tyr-454 and inhibits signaling through dephosphorylation of JAK2. APS binding also inhibits the JAK-STAT signaling. Binding to PTPN11, preferentially through the N-terminal SH2 domain, promotes mitogenesis and phosphorylation of PTPN11. Binding of JAK2 (through its N-terminal) promotes cell-surface expression. Interaction with the ubiquitin ligase NOSIP mediates EPO-induced cell proliferation. Interacts with ATXN2L and INPP5D/SHIP1 (By similarity).
messages: Membrane
messages: On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2. The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation. Phosphorylation on Tyr-454 is required for PTPN6 interaction, Tyr-426 for PTPN11. Tyr-426 is also required for SOCS3 binding, but Tyr-454/Tyr-456 motif is the preferred binding site (By similarity).
messages: Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: Ubiquitinated by NOSIP; appears to be either multi-monoubiquitinated or polyubiquitinated. Ubiquitination mediates proliferation and survival of EPO-dependent cells. Ubiquitination at Lys-281 mediates receptor internalization, whereas ubiquitination at Lys-453 promotes trafficking of activated receptors to the lysosomes for degradation (By similarity).

9615:C1R
gene id: 9615:C1R
uniprot id: A0A8C0RPP3
uniprot id: A0A8I3PTX7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TRAPPC11
gene id: 9615:TRAPPC11
uniprot id: A0A8C0NF92
uniprot id: A0A8I3NTW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPPC11 family.
messages: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
messages: cis-Golgi network

9615:PPM1D
gene id: 9615:PPM1D
uniprot id: A0A8C0RSS8
names: Similarity
messages: Belongs to the PP2C family.

9615:ATP6V0A1
gene id: 9615:ATP6V0A1
uniprot id: A0A8C0LW48
uniprot id: A0A8C0S097
uniprot id: A0A8I3NLM3
uniprot id: A0A8I3RWI5
uniprot id: A0A8P0NGI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9615:CAMK2D
gene id: 9615:CAMK2D
uniprot id: A0A8C0PCX9
uniprot id: A0A8C0RPG2
uniprot id: A0A8C0RPZ7
uniprot id: A0A8C0TWG0
uniprot id: A0A8C0Z6Z6
uniprot id: A0A8I3Q1E3
uniprot id: A0A8I3Q5E5
uniprot id: A0A8I3QQ41
uniprot id: A0A8I3QQ80
uniprot id: A0A8P0P6N4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9615:PARP9
gene id: 9615:PARP9
uniprot id: A0A8P0NE46
names: Similarity
messages: Belongs to the ARTD/PARP family.

9615:NDUFB8
gene id: 9615:NDUFB8
uniprot id: A0A8I3NUH5
uniprot id: A0A8P0SPY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:ACOD1
gene id: 9615:ACOD1
uniprot id: A0A8C0RF82
uniprot id: A0A8I3PS95
names: Similarity
messages: Belongs to the PrpD family.

9615:MVP
gene id: 9615:MVP
uniprot id: A0A8C0SNT7
uniprot id: A0A8I3MGN1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

9615:LOC484492
gene id: 9615:LOC484492
uniprot id: A0A8C0S3F2
uniprot id: A0A8I3MK53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:GPM6B
gene id: 9615:GPM6B
uniprot id: A0A8C0RPC5
uniprot id: A0A8C0RPH1
uniprot id: A0A8C0SCF8
uniprot id: A0A8C0YWP6
uniprot id: A0A8I3QRI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9615:TMED5
gene id: 9615:TMED5
uniprot id: A0A8C0MY53
uniprot id: A0A8I3NKL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9615:UCN
gene id: 9615:UCN
uniprot id: A0A8C0MNQ4
uniprot id: A0A8I3MZB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9615:USP11
gene id: 9615:USP11
uniprot id: A0A8C0T0P0
uniprot id: A0A8I3QL54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9615:TGFB3
gene id: 9615:TGFB3
uniprot id: A0A8C0SQX7
uniprot id: A0A8I3S1P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

9615:OR4C11D
gene id: 9615:OR4C11D
uniprot id: A0A8P0PJQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SPTAN1
gene id: 9615:SPTAN1
uniprot id: A0A8I3Q1F4
uniprot id: A0A8P0SP17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9615:ACTB
gene id: 9615:ACTB
uniprot id: O18840
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
messages: Belongs to the actin family.
messages: ISGylated.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-73 by SETD3 (By similarity). Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (By similarity).
messages: Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.
messages: N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP.
messages: Nucleus
messages: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM (By similarity). Interacts with TBC1D21. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes. Interacts with FAM107A (By similarity). Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The filament contains 8 copies of ACTR1A and 1 ACTB (By similarity).
messages: cytoskeleton

9615:ARL6IP5
gene id: 9615:ARL6IP5
uniprot id: A0A8C0S516
uniprot id: A0A8I3NDE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9615:SLC7A5
gene id: 9615:SLC7A5
uniprot id: K0J2W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9615:DLG2
gene id: 9615:DLG2
uniprot id: A0A8C0MP26
uniprot id: A0A8I3N790
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane

9615:ATP5MC3
gene id: 9615:ATP5MC3
uniprot id: A0A8C0SWP7
uniprot id: A0A8I3PAW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9615:MCM6
gene id: 9615:MCM6
uniprot id: A0A8C0NN33
uniprot id: A0A8I3N2T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9615:KRT89
gene id: 9615:KRT89
uniprot id: A0A8C0PAT3
names: Similarity
messages: Belongs to the intermediate filament family.

9615:CYP2W1
gene id: 9615:CYP2W1
uniprot id: A0A8P0NDQ1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:DGKQ
gene id: 9615:DGKQ
uniprot id: A0A8I3MGJ8
uniprot id: A0A8P0SPN9
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9615:BRD1
gene id: 9615:BRD1
uniprot id: A0A8C0T538
uniprot id: A0A8I3MXH0
names: Subcellular Location Annotation
messages: Nucleus

9615:KRT86
gene id: 9615:KRT86
uniprot id: A0A8C0P392
uniprot id: A0A8I3PYC8
names: Similarity
messages: Belongs to the intermediate filament family.

9615:MMS19
gene id: 9615:MMS19
uniprot id: A0A8C0TUL3
uniprot id: A0A8I3Q0Q0
uniprot id: A0A8P0P2R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9615:CALHM3
gene id: 9615:CALHM3
uniprot id: A0A8P0NCJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9615:COQ8B
gene id: 9615:COQ8B
uniprot id: A0A8C0S6L3
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9615:IL6
gene id: 9615:IL6
uniprot id: P41323
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
messages: Belongs to the IL-6 superfamily.
messages: Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.
messages: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
messages: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).
messages: Secreted

9615:FMO3
gene id: 9615:FMO3
uniprot id: Q95LA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Microsome membrane

9615:BLCAP
gene id: 9615:BLCAP
uniprot id: A0A8C0T230
uniprot id: A0A8I3PW53
names: Similarity
messages: Belongs to the BLCAP family.

9615:FOXO3
gene id: 9615:FOXO3
uniprot id: A0A8C0YUF9
uniprot id: A0A8I3N2V0
names: Subcellular Location Annotation
messages: Nucleus

9615:NCAPG
gene id: 9615:NCAPG
uniprot id: A0A8C0LXX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9615:SLC1A5
gene id: 9615:SLC1A5
uniprot id: K7ZSN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9615:PPP2R2C
gene id: 9615:PPP2R2C
uniprot id: A0A8C0RVD5
uniprot id: A0A8I3N643
uniprot id: A0A8P0SIY7
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9615:PLPP1
gene id: 9615:PLPP1
uniprot id: A0A8C0PSQ9
uniprot id: A0A8I3PY74
uniprot id: A0A8I3S6B5
uniprot id: A0A8I3SAU2
uniprot id: A0A8P0TCV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9615:COMTD1
gene id: 9615:COMTD1
uniprot id: A0A8C0NR95
uniprot id: A0A8I3NR09
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9615:ARL2
gene id: 9615:ARL2
uniprot id: A0A8C0Z3L5
uniprot id: A0A8I3SAX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9615:TMEFF2
gene id: 9615:TMEFF2
uniprot id: A0A8C0RNL4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:LOC480600
gene id: 9615:LOC480600
uniprot id: A0A8C0NXT2
uniprot id: A0A8I3NLR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9615:AP2A1
gene id: 9615:AP2A1
uniprot id: A0A8C0LU67
uniprot id: A0A8C0M3V6
uniprot id: A0A8I3S2R3
uniprot id: A0A8I3S565
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9615:MED16
gene id: 9615:MED16
uniprot id: A0A8P0NKQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:CCN3
gene id: 9615:CCN3
uniprot id: A0A8C0RCV6
uniprot id: A0A8I3N0U3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:CYFIP2
gene id: 9615:CYFIP2
uniprot id: A0A8C0MWY8
names: Similarity
messages: Belongs to the CYFIP family.

9615:UBLCP1
gene id: 9615:UBLCP1
uniprot id: A0A8C0PYA1
uniprot id: A0A8I3MIL5
names: Subcellular Location Annotation
messages: Nucleus

9615:GPR132
gene id: 9615:GPR132
uniprot id: A0A8I3PBK9
uniprot id: A0A8P0PRS8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:GATA1
gene id: 9615:GATA1
uniprot id: A0A8C0S1L4
uniprot id: A0A8I3QVV2
names: Subcellular Location Annotation
messages: Nucleus

9615:TMEM167B
gene id: 9615:TMEM167B
uniprot id: A0A8I3MLM0
uniprot id: A0A8P0PQB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:PLPBP
gene id: 9615:PLPBP
uniprot id: A0A8C0SFM2
uniprot id: A0A8I3NH39
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

9615:BRMS1L
gene id: 9615:BRMS1L
uniprot id: A0A8C0TIF0
uniprot id: A0A8I3RQR5
names: Subcellular Location Annotation
messages: Nucleus

9615:NEIL3
gene id: 9615:NEIL3
uniprot id: A0A8I3S0H3
uniprot id: A0A8P0NSR9
names: Similarity
messages: Belongs to the FPG family.

9615:XYLB
gene id: 9615:XYLB
uniprot id: A0A8I3Q4W2
uniprot id: A0A8P0SAM4
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

9615:XRCC6
gene id: 9615:XRCC6
uniprot id: E2RRK6
names: Subcellular Location Annotation
messages: Nucleus

9615:OR4K6
gene id: 9615:OR4K6
uniprot id: A0A8C0THY2
uniprot id: A0A8I3S2R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ADAM32
gene id: 9615:ADAM32
uniprot id: A0A8I3NHM2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SPACA3
gene id: 9615:SPACA3
uniprot id: B6VH75
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although it belongs to the glycosyl hydrolase 22 family, Thr-70 and Asn-87 are present instead of the conserved Glu and Asp which are active site residues. It is therefore expected that this protein lacks hydrolase activity.
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Interacts with ASTL.
messages: Secreted
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro (By similarity).

9615:SLC35E4
gene id: 9615:SLC35E4
uniprot id: A0A8C0TIR2
names: Subcellular Location Annotation
messages: Membrane

9615:ALOX5
gene id: 9615:ALOX5
uniprot id: E7ECW0
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:GHRL
gene id: 9615:GHRL
uniprot id: Q9BEF8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Amidation of Leu-98 is essential for obestatin activity.
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity).
messages: O-octanoylated by GOAT/MBOAT4 (By similarity). O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
messages: Secreted

9615:TLR3
gene id: 9615:TLR3
uniprot id: A0A8I3P6K4
uniprot id: A0A8P0SCN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9615:GET3
gene id: 9615:GET3
uniprot id: A0A8C0RP10
uniprot id: A0A8I3NZF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

9615:SEMA6D
gene id: 9615:SEMA6D
uniprot id: A0A8C0N5C6
uniprot id: A0A8C0N7M0
uniprot id: A0A8C0N9J2
uniprot id: A0A8C0NEG0
uniprot id: A0A8I3P2D6
uniprot id: A0A8I3P3J3
uniprot id: A0A8I3P723
uniprot id: A0A8I3P7E8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:EVL
gene id: 9615:EVL
uniprot id: A0A8P0NJA8
uniprot id: A0A8P0NTU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

9615:RCVRN
gene id: 9615:RCVRN
uniprot id: Q8MIH6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity).
messages: Belongs to the recoverin family.
messages: EF-hand 2 and EF-hand 3 domains are the low-affinity and the high-affinity calcium binding sites, respectively. EF-hand 1 and EF-hand 4 domains do not bind calcium due to substitutions that disrupt their respective Ca(2+) binding loops. The cooperative binding of calcium to the EF-hand 2 domain following EF-hand 3 domain calcium binding requires myristoylation (By similarity). Calcium binding to the 2 EF-hand domains induces exposure of the myristoyl group through a protein conformation change, this process known as the calcium-myristoyl switch facilitates binding to photoreceptor cell membranes (By similarity).
messages: Homodimer; disulfide-linked (By similarity). Homodimerization is caused by prolonged intense illumination (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity). Interacts (via C-terminus) with GRK1 (via N-terminus); the interaction is Ca(2+)-dependent (By similarity).
messages: Oxidation on Cys-39 occurs in response to prolonged intense illumination and results in the formation of disulfide homodimers, and to a lesser extent disulfide-linked heterodimers.
messages: Perikaryon
messages: Photoreceptor inner segment
messages: Photoreceptor outer segment membrane
messages: The N-terminal glycine is linked to one of four different types of acyl groups. The most abundant is myristoleate (14:1), but 14:0, 14:2, and 12:0 acyl residues are also present (By similarity). The Ca(2+) induced exposure of the myristoyl group, known as the calcium-myristoyl switch, promotes RCVRN binding to the photoreceptor cell membranes only when intracellular Ca(2+) concentration is high (By similarity).
messages: photoreceptor outer segment

9615:PPP6R1
gene id: 9615:PPP6R1
uniprot id: A0A8I3RRF7
uniprot id: A0A8P0SRI8
names: Similarity
messages: Belongs to the SAPS family.

9615:FGFR1OP2
gene id: 9615:FGFR1OP2
uniprot id: A0A8C0Z3U2
uniprot id: E2QV81
names: Similarity
messages: Belongs to the SIKE family.

9615:PARG
gene id: 9615:PARG
uniprot id: A0A8C0P983
uniprot id: A0A8I3S6T0
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9615:GLG1
gene id: 9615:GLG1
uniprot id: A0A8C0SKW4
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

9615:NDST2
gene id: 9615:NDST2
uniprot id: A0A8C0MWW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9615:TPM4
gene id: 9615:TPM4
uniprot id: A0A0N9JE84
uniprot id: A0A8C0P9W8
uniprot id: A0A8C0RR32
uniprot id: A0A8C0T3W1
uniprot id: A0A8I3Q497
uniprot id: A0A8I3Q6P3
uniprot id: A0A8P0T3C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9615:TRNAU1AP
gene id: 9615:TRNAU1AP
uniprot id: A0A8C0MWQ5
uniprot id: A0A8I3ND40
uniprot id: A0A8I3RVI7
uniprot id: A0A8P0PQJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9615:FAR2
gene id: 9615:FAR2
uniprot id: A0A8C0T3P5
uniprot id: A0A8I3PFK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9615:TNFAIP6
gene id: 9615:TNFAIP6
uniprot id: A0A8P0SB54
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:DEF8
gene id: 9615:DEF8
uniprot id: A0A8C0MUU1
names: Similarity
messages: Belongs to the DEF8 family.

9615:HDAC7
gene id: 9615:HDAC7
uniprot id: A0A8P0P3P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9615:TRAPPC13
gene id: 9615:TRAPPC13
uniprot id: A0A8C0Q8F9
uniprot id: A0A8C0RB32
uniprot id: A0A8I3N472
uniprot id: A0A8I3NFN1
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9615:IVL
gene id: 9615:IVL
uniprot id: A0A8C0NQ79
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the involucrin family.
messages: Cytoplasm
messages: Directly or indirectly cross-linked to cornifelin (CNFN).
messages: Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
messages: Substrate of transglutaminase.

9615:THOC6
gene id: 9615:THOC6
uniprot id: A0A8C0RB54
uniprot id: A0A8I3MPA7
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9615:FAM168A
gene id: 9615:FAM168A
uniprot id: A0A8I3N4Q8
uniprot id: A0A8P0PPV2
names: Similarity
messages: Belongs to the FAM168 family.

9615:SLC25A45
gene id: 9615:SLC25A45
uniprot id: A0A8C0MUE4
uniprot id: A0A8C0N1L2
uniprot id: A0A8I3PS25
uniprot id: A0A8I3Q2S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:LCA5
gene id: 9615:LCA5
uniprot id: A0A8C0MHI8
uniprot id: A0A8I3N1H3
names: Similarity
messages: Belongs to the LCA5 family.

9615:ATP6V0E1
gene id: 9615:ATP6V0E1
uniprot id: Q9BDP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).

9615:CCL3
gene id: 9615:CCL3
uniprot id: A0A8C0PE59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9615:DPH3
gene id: 9615:DPH3
uniprot id: A0A8C0PSZ8
uniprot id: A0A8I3PM03
names: Similarity
messages: Belongs to the DPH3 family.

9615:GFAP
gene id: 9615:GFAP
uniprot id: A0A8C0SII5
uniprot id: A0A8C0YXL1
uniprot id: A0A8I3RTB4
names: Similarity
messages: Belongs to the intermediate filament family.

9615:HOXA6
gene id: 9615:HOXA6
uniprot id: A0A8C0S4D1
uniprot id: A0A8I3RWG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:PTGR2
gene id: 9615:PTGR2
uniprot id: A0A8I3NQ20
uniprot id: A0A8P0NI88
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9615:C20H19orf53
gene id: 9615:C20H19orf53
uniprot id: A0A8C0T8U1
uniprot id: A0A8I3PRP3
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9615:LOC100686265
gene id: 9615:LOC100686265
uniprot id: A0A8I3P7T0
uniprot id: A0A8P0PPI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9615:KRT13
gene id: 9615:KRT13
uniprot id: A0A8C0S9A5
names: Similarity
messages: Belongs to the intermediate filament family.

9615:SAR1B
gene id: 9615:SAR1B
uniprot id: A0A8C0QFD7
uniprot id: A0A8I3NZH7
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9615:RPS17
gene id: 9615:RPS17
uniprot id: P63273
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS17 family.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: Ubiquitinated at Lys-103 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).
messages: nucleolus

9615:KATNB1
gene id: 9615:KATNB1
uniprot id: A0A8C0M431
uniprot id: A0A8I3N368
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9615:FAM162B
gene id: 9615:FAM162B
uniprot id: A0A8C0Q5F8
uniprot id: A0A8I3MUH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9615:LOC485869
gene id: 9615:LOC485869
uniprot id: A0A8C0T6S1
uniprot id: A0A8I3S716
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

9615:GALNT15
gene id: 9615:GALNT15
uniprot id: A0A8C0PT53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:PEMT
gene id: 9615:PEMT
uniprot id: A0A8C0LX23
uniprot id: A0A8I3S7Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9615:PSEN1
gene id: 9615:PSEN1
uniprot id: A0A8C0PFQ1
uniprot id: A0A8I3RZ86
uniprot id: Q56JJ5
uniprot id: Q6RH31
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After endoproteolysis, the C-terminal fragment (CTF) is phosphorylated on serine residues by PKA and/or PKC. Phosphorylation on Ser-345 inhibits endoproteolysis.
messages: Belongs to the peptidase A22A family.
messages: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (By similarity). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis. Involved in the regulation of neurite outgrowth (By similarity). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity).
messages: Cell membrane
messages: Cytoplasmic granule
messages: Early endosome
messages: Early endosome membrane
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by caspase-3 to produce the fragment, PS1-CTF12.
messages: Homodimer.
messages: Homodimer. The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity. Other components which are associated with the complex include SLC25A64, SLC5A7 and PHB. As part of the gamma-secretase complex, interacts with CRB2 (via transmembrane domain) (By similarity). Predominantly heterodimer of a N-terminal (NTF) and a C-terminal (CTF) endoproteolytical fragment. Associates with proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Associates with NOTCH1. Associates with cadherin/catenin adhesion complexes through direct binding to CDH1 or CDH2 (PubMed:11226248). Interaction with CDH1 stabilizes the complex and stimulates cell-cell aggregation. Interaction with CDH2 is essential for trafficking of CDH2 from the endoplasmic reticulum to the plasma membrane. Interacts with CTNND2, CTNNB1, CTNND1, JUP, HERPUD1, FLNA, FLNB, MTCH1, PKP4 and PARL. Interacts through its N-terminus with GFAP (By similarity). Interacts with DOCK3 (By similarity). Interacts with UBQLN1 (By similarity).
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Substrates, such as NOTCH1 and APP peptides, are bound between PSEN1 transmembrane domains and via the first lumenal loop and the cytoplasmic loop between the sixth and seventh transmembrane domains. Substrate binding causes a conformation change and formation of an intermolecular antiparallel beta-sheet between PSEN1 and its substrates.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: growth cone
messages: neuron projection

9615:TAGLN
gene id: 9615:TAGLN
uniprot id: A0A8C0RDD6
names: Similarity
messages: Belongs to the calponin family.

9615:HDAC3
gene id: 9615:HDAC3
uniprot id: A0A8C0M140
uniprot id: A0A8I3P468
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9615:CX3CR1
gene id: 9615:CX3CR1
uniprot id: A0A8P0PGL9
uniprot id: H1ADZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9615:PSMC1
gene id: 9615:PSMC1
uniprot id: A0A8C0LUS7
names: Similarity
messages: Belongs to the AAA ATPase family.

9615:TBL3
gene id: 9615:TBL3
uniprot id: A0A8I3P2Y5
uniprot id: A0A8P0NKI1
names: Subcellular Location Annotation
messages: COPI-coated vesicle membrane
messages: nucleolus

9615:OSBPL3
gene id: 9615:OSBPL3
uniprot id: A0A8C0QM67
uniprot id: A0A8C0QPP8
uniprot id: A0A8P0PCL0
names: Similarity
messages: Belongs to the OSBP family.

9615:LPCAT2
gene id: 9615:LPCAT2
uniprot id: A0A8C0S2N3
uniprot id: A0A8I3MG02
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9615:CNN3
gene id: 9615:CNN3
uniprot id: A0A8P0SP42
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9615:CD63
gene id: 9615:CD63
uniprot id: A0A8C0NFC7
uniprot id: A0A8I3N083
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9615:TRARG1
gene id: 9615:TRARG1
uniprot id: A0A8C0RVG4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9615:FGFR4
gene id: 9615:FGFR4
uniprot id: A0A8C0M6P0
uniprot id: A0A8I3NCC1
uniprot id: A0A8P0NHY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:DNAJC16
gene id: 9615:DNAJC16
uniprot id: A0A8C0NGF5
uniprot id: A0A8I3MHI1
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

9615:NSUN5
gene id: 9615:NSUN5
uniprot id: A0A8C0MWW7
uniprot id: A0A8I3MRS9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9615:PHB
gene id: 9615:PHB
uniprot id: A0A8P0PG28
uniprot id: A8W340
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9615:DYM
gene id: 9615:DYM
uniprot id: A0A8I3P124
uniprot id: A0A8P0SNE2
names: Similarity
messages: Belongs to the dymeclin family.

9615:RPSA
gene id: 9615:RPSA
uniprot id: A0A8C0N0T1
uniprot id: A0A8I3NYW8
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9615:LOC480784
gene id: 9615:LOC480784
uniprot id: A0A1K0GGH0
uniprot id: A0A8P0T9E7
names: Similarity
messages: Belongs to the globin family.

9615:WEE1
gene id: 9615:WEE1
uniprot id: A0A8C0MJT1
uniprot id: A0A8I3NRX2
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

9615:FLOT1
gene id: 9615:FLOT1
uniprot id: A0A8C0RE82
uniprot id: A0A8I3NJ91
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: Membrane
messages: caveola

9615:GNMT
gene id: 9615:GNMT
uniprot id: A0A8C0RZP0
uniprot id: A0A8I3RV36
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9615:EIF5A
gene id: 9615:EIF5A
uniprot id: A0A8C0RIV2
uniprot id: A0A8I3PFB8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

9615:RPL9
gene id: 9615:RPL9
uniprot id: A0A8C0MIW9
uniprot id: A0A8I3MSX4
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

9615:KCNS2
gene id: 9615:KCNS2
uniprot id: A0A8C0YXK7
uniprot id: A0A8I3PT46
names: Subcellular Location Annotation
messages: Membrane

9615:PPP1R1C
gene id: 9615:PPP1R1C
uniprot id: A0A8C0MPX7
uniprot id: A0A8I3NWG8
uniprot id: A0A8P0SJ63
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9615:DYNLRB1
gene id: 9615:DYNLRB1
uniprot id: A0A8C0QBF7
uniprot id: A0A8I3NZF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9615:PIGF
gene id: 9615:PIGF
uniprot id: A0A8C0S322
uniprot id: A0A8I3PUP6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:YJU2
gene id: 9615:YJU2
uniprot id: A0A8C0RCB0
uniprot id: A0A8I3MRK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

9615:ERAL1
gene id: 9615:ERAL1
uniprot id: A0A8C0MZS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

9615:ACTL6A
gene id: 9615:ACTL6A
uniprot id: A0A8C0T696
names: Similarity
messages: Belongs to the actin family.

9615:SLC39A13
gene id: 9615:SLC39A13
uniprot id: A0A8I3S505
uniprot id: A0A8P0NB15
names: Subcellular Location Annotation
messages: Membrane

9615:NOS3
gene id: 9615:NOS3
uniprot id: A0A8C0Q3E0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

9615:FOXA3
gene id: 9615:FOXA3
uniprot id: A0A8C0MCB7
uniprot id: A0A8I3MX60
names: Subcellular Location Annotation
messages: Nucleus

9615:CASR
gene id: 9615:CASR
uniprot id: A0A8C0NAC8
uniprot id: A2SXS6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:STAT3
gene id: 9615:STAT3
uniprot id: A0A8C0QJT6
uniprot id: A0A8I3RV66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9615:RNF10
gene id: 9615:RNF10
uniprot id: A0A8C0TAY8
uniprot id: A0A8I3Q1R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

9615:FBP1
gene id: 9615:FBP1
uniprot id: A0A8C0QC07
uniprot id: A0A8I3MZ42
names: Similarity
messages: Belongs to the FBPase class 1 family.

9615:GRPR
gene id: 9615:GRPR
uniprot id: A0A8C0SJC7
uniprot id: A0A8I3Q5H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:TBX21
gene id: 9615:TBX21
uniprot id: A0A8C0Q056
uniprot id: A0A8I3P525
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:TLR8
gene id: 9615:TLR8
uniprot id: A0A8P0PHY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9615:SNX2
gene id: 9615:SNX2
uniprot id: A0A8I3RW49
uniprot id: A0A8P0TKV9
names: Similarity
messages: Belongs to the sorting nexin family.

9615:LOC481841
gene id: 9615:LOC481841
uniprot id: A0A8C0RN11
uniprot id: A0A8I3NC82
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9615:LCN8
gene id: 9615:LCN8
uniprot id: A0A8C0M8W2
uniprot id: A0A8C0SP07
uniprot id: A0A8C0SQR2
uniprot id: A0A8I3MWP0
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9615:RFLNB
gene id: 9615:RFLNB
uniprot id: A0A8C0RLD5
uniprot id: A0A8I3NLU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9615:MAP4K2
gene id: 9615:MAP4K2
uniprot id: A0A8C0MFB8
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9615:GORAB
gene id: 9615:GORAB
uniprot id: A0A8P0NGN5
names: Similarity
messages: Belongs to the GORAB family.

9615:MLH3
gene id: 9615:MLH3
uniprot id: A0A8C0SJ31
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9615:GDF10
gene id: 9615:GDF10
uniprot id: A0A8I3N6I7
uniprot id: A0A8P0NHU7
names: Similarity
messages: Belongs to the TGF-beta family.

9615:FAM216A
gene id: 9615:FAM216A
uniprot id: A0A8C0TA94
uniprot id: A0A8I3Q4M8
names: Similarity
messages: Belongs to the FAM216 family.

9615:CHRDL1
gene id: 9615:CHRDL1
uniprot id: A0A8C0NVX0
names: Subcellular Location Annotation
messages: Secreted

9615:TMEM54
gene id: 9615:TMEM54
uniprot id: A0A8I3MZ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9615:MZT2B
gene id: 9615:MZT2B
uniprot id: A0A8C0RSE1
uniprot id: A0A8I3PUW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

9615:CLDN24
gene id: 9615:CLDN24
uniprot id: A0A8C0N3V6
uniprot id: A0A8I3P0C6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:P2RY1
gene id: 9615:P2RY1
uniprot id: A0A8C0N762
uniprot id: Q5XX73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:SLC1A4
gene id: 9615:SLC1A4
uniprot id: A0A8C0Q4G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9615:KRTCAP3
gene id: 9615:KRTCAP3
uniprot id: A0A8C0S8M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9615:CALCA
gene id: 9615:CALCA
uniprot id: Q9MYV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP (By similarity).
messages: Secreted

9615:COQ2
gene id: 9615:COQ2
uniprot id: A0A8C0N168
uniprot id: A0A8I3PBV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

9615:OR4D9B
gene id: 9615:OR4D9B
uniprot id: A0A8I3P7S6
uniprot id: A0A8P0SVF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CCT3
gene id: 9615:CCT3
uniprot id: A0A8C0T730
uniprot id: A0A8I3RV88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9615:KCNJ8
gene id: 9615:KCNJ8
uniprot id: A0A8C0P7N1
uniprot id: A0A8I3NUB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9615:ALG2
gene id: 9615:ALG2
uniprot id: A0A8C0T6X6
uniprot id: A0A8I3N4U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

9615:HPSE2
gene id: 9615:HPSE2
uniprot id: A0A8C0PC36
uniprot id: A0A8I3QTG2
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9615:INVS
gene id: 9615:INVS
uniprot id: Q6JAN1
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds calmodulin via its IQ domains. Interacts with APC2. Interacts with alpha-, beta-, and gamma-catenin. Interacts with N-cadherin (CDH2). Interacts with NPHP1. Interacts with DVL1, PRICKLE (PRICKLE1 or PRICKLE2) and Strabismus (VANGL1 or VANGL2). Component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3. ANKS6 may organize complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target the complex to the proximal ciliary axoneme. Interacts with IQCB1; the interaction likely requires additional interactors (By similarity). Interacts with microtubules.
messages: Hydroxylated at Asn-75, most probably by HIF1AN.
messages: May be ubiquitinated via its interaction with APC2.
messages: Membrane
messages: Nuclear prior to nuclear envelope breakdown. Localizes at the centrosomes in early prophase but in metaphase and anaphase, it localizes to the spindle poles In cells at late telophase undergoing cytokinesis it is detected at the midbody, a region of microtubule overlap (at protein level).
messages: Nucleus
messages: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
messages: The D-box 1 (destruction box 1) mediates the interaction with APC2, and may act as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: cytoskeleton
messages: spindle

9615:NRM
gene id: 9615:NRM
uniprot id: A0A8C0REE3
uniprot id: A0A8I3N6N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9615:ZFP36L1
gene id: 9615:ZFP36L1
uniprot id: A0A8C0SGM8
uniprot id: A0A8I3MS54
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9615:NFASC
gene id: 9615:NFASC
uniprot id: A0A8C0MZN5
uniprot id: A0A8C0RH49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Cell membrane

9615:SLC2A12
gene id: 9615:SLC2A12
uniprot id: A0A8I3MPM4
uniprot id: A0A8P0PF31
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9615:PPTC7
gene id: 9615:PPTC7
uniprot id: A0A8C0Z2Z9
uniprot id: A0A8I3Q3I9
names: Similarity
messages: Belongs to the PP2C family.

9615:LOC488494
gene id: 9615:LOC488494
uniprot id: A0A8C0YUX5
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9615:BET1L
gene id: 9615:BET1L
uniprot id: A0A8C0ML66
uniprot id: A0A8I3PVR4
names: Subcellular Location Annotation
messages: Membrane

9615:NXPH3
gene id: 9615:NXPH3
uniprot id: A0A8C0LV14
uniprot id: A0A8I3N8F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9615:MRPS10
gene id: 9615:MRPS10
uniprot id: A0A8C0RD71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

9615:YARS1
gene id: 9615:YARS1
uniprot id: A0A8C0NIQ1
uniprot id: A0A8C0TAE6
uniprot id: A0A8I3MXN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Nucleus

9615:CNNM4
gene id: 9615:CNNM4
uniprot id: A0A8C0T231
uniprot id: A0A8C0T477
uniprot id: A0A8I3PEA1
uniprot id: A0A8I3PI07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9615:LOC100855689
gene id: 9615:LOC100855689
uniprot id: A0A8I3S8S6
uniprot id: A0A8P0TNX4
names: Similarity
messages: Belongs to the SPIN/STSY family.

9615:CHMP2B
gene id: 9615:CHMP2B
uniprot id: A0A8I3PS98
names: Similarity
messages: Belongs to the SNF7 family.

9615:HOMER1
gene id: 9615:HOMER1
uniprot id: A0A8C0NFB8
uniprot id: A0A8I3RUZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9615:YTHDF3
gene id: 9615:YTHDF3
uniprot id: A0A8C0T3T8
uniprot id: A0A8C0T3Z7
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9615:SAXO2
gene id: 9615:SAXO2
uniprot id: A0A8C0QHS4
uniprot id: A0A8I3MND2
names: Similarity
messages: Belongs to the FAM154 family.

9615:MRPS36
gene id: 9615:MRPS36
uniprot id: A0A8C0RXD8
uniprot id: A0A8I3NHA4
names: Subcellular Location Annotation
messages: Mitochondrion

9615:ABCA4
gene id: 9615:ABCA4
uniprot id: Q5ZGW1
names: Subcellular Location Annotation
messages: Membrane

9615:RNPS1
gene id: 9615:RNPS1
uniprot id: A0A8C0T981
uniprot id: A0A8C0T9B0
uniprot id: A0A8I3MQA2
uniprot id: A0A8I3MQC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
messages: Nucleus speckle

9615:GNPDA1
gene id: 9615:GNPDA1
uniprot id: A0A8C0M522
uniprot id: A0A8I3NTY8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9615:SLC22A18
gene id: 9615:SLC22A18
uniprot id: A0A8C0PH66
uniprot id: A0A8I3NJX9
names: Subcellular Location Annotation
messages: Membrane

9615:CCL22
gene id: 9615:CCL22
uniprot id: A0A8C0M8G7
uniprot id: A0A8I3MLU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9615:OR11G5
gene id: 9615:OR11G5
uniprot id: A0A8C0RGE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ABCA6
gene id: 9615:ABCA6
uniprot id: A0A8P0ND09
names: Subcellular Location Annotation
messages: Membrane

9615:ADGRG6
gene id: 9615:ADGRG6
uniprot id: A0A8C0LT01
uniprot id: A0A8I3NI40
uniprot id: A0A8P0T106
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:RPTOR
gene id: 9615:RPTOR
uniprot id: A0A8C0MJH0
uniprot id: A0A8I3NME4
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

9615:VAMP8
gene id: 9615:VAMP8
uniprot id: A0A8C0Q438
uniprot id: A0A8I3NH32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9615:USP16
gene id: 9615:USP16
uniprot id: A0A8C0NMA6
uniprot id: A0A8I3NWU5
uniprot id: A0A8I3P135
uniprot id: A0A8P0T096
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9615:GNB3
gene id: 9615:GNB3
uniprot id: A9UHL9
uniprot id: P79147
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2 (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: perinuclear region

9615:CHRD
gene id: 9615:CHRD
uniprot id: A0A8C0MSV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chordin family.
messages: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
messages: Secreted

9615:AKIRIN2
gene id: 9615:AKIRIN2
uniprot id: A0A8C0S3B4
uniprot id: A0A8I3N1B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9615:COX11
gene id: 9615:COX11
uniprot id: A0A8C0RIZ0
uniprot id: A0A8I3NUH7
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

9615:CALCR
gene id: 9615:CALCR
uniprot id: A0A8C0YVA6
uniprot id: B3XXF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane

9615:NECAP2
gene id: 9615:NECAP2
uniprot id: A0A8C0Q7E9
uniprot id: A0A8C0RWL7
uniprot id: A0A8I3MT64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9615:IRX2
gene id: 9615:IRX2
uniprot id: A0A8C0N5G3
uniprot id: A0A8I3PP48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9615:UNC5C
gene id: 9615:UNC5C
uniprot id: A0A8C0T632
uniprot id: A0A8C0T9A6
uniprot id: A0A8I3PF54
uniprot id: A0A8I3S2Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9615:RIOK3
gene id: 9615:RIOK3
uniprot id: A0A8C0PJU6
uniprot id: A0A8I3NRB3
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.

9615:RAD52
gene id: 9615:RAD52
uniprot id: A0A8C0TZH2
uniprot id: A0A8I3Q232
names: Similarity
messages: Belongs to the RAD52 family.

9615:CDNF
gene id: 9615:CDNF
uniprot id: A0A8C0NI63
uniprot id: A0A8I3P4A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9615:LOC490387
gene id: 9615:LOC490387
uniprot id: A0A8C0SBM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9615:TMEM38A
gene id: 9615:TMEM38A
uniprot id: A0A8P0SU84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9615:TSPAN33
gene id: 9615:TSPAN33
uniprot id: A0A8I3PDH6
uniprot id: A0A8P0S7G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:WDR83OS
gene id: 9615:WDR83OS
uniprot id: A0A8C0TSD6
uniprot id: A0A8I3NQW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Asterix family.
messages: Component of the PAT complex, composed of WDR83OS/Asterix and CCDC47 (PubMed:36261528). The PAT complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47) (PubMed:36261528). The MPT complex associates with the SEC61 complex (PubMed:36261528).
messages: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261528). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261528). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (PubMed:36261528). Within the PAT subcomplex, WDR83OS/Asterix binds to and redirects the substrate to a location behind the SEC61 complex (PubMed:36261528).
messages: Endoplasmic reticulum membrane

9615:NXPE3
gene id: 9615:NXPE3
uniprot id: A0A8P0SEJ9
names: Similarity
messages: Belongs to the NXPE family.

9615:PPM1G
gene id: 9615:PPM1G
uniprot id: A0A8C0S6T1
uniprot id: A0A8I3N2G1
names: Similarity
messages: Belongs to the PP2C family.

9615:TMEM263
gene id: 9615:TMEM263
uniprot id: A0A8C0MF73
uniprot id: A0A8I3NAS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

9615:RAB27A
gene id: 9615:RAB27A
uniprot id: Q1HE58
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Binds SYTL1, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5. Interacts with RPH3A and RPH3A (By similarity). Binds MLPH and SYTL2. Interacts with UNC13D. Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4) (By similarity). Interacts (GDP-bound form preferentially) with DENND10 (By similarity).
messages: Late endosome
messages: Lysosome
messages: Melanosome
messages: Membrane
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as DENND10.
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.

9615:OAS2
gene id: 9615:OAS2
uniprot id: A0A8C0TPI8
uniprot id: Q2KM16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9615:PIK3CD
gene id: 9615:PIK3CD
uniprot id: A0A8C0MJU5
uniprot id: A0A8I3Q525
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9615:AK5
gene id: 9615:AK5
uniprot id: A0A8P0SPG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

9615:TRPV1
gene id: 9615:TRPV1
uniprot id: Q697L1
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
messages: Cell membrane
messages: Channel activity is activated via the interaction with PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity. The channel is sensitized by ATP binding. Repeated stimulation with capsaicin gives rise to progressively smaller responses, due to desensitization. This desensitization is triggered by the influx of calcium ions and is inhibited by elevated ATP levels. Ca(2+) and CALM displace ATP from its binding site and trigger a conformation change that leads to a closed, desensitized channel. Intracellular PIP2 inhibits desensitization. The double-knot toxin (DkTx) from the Chinese earth tiger tarantula activates the channel and traps it in an open conformation (By similarity). The Scolopendra mutilans RhTx toxin potentiates the heat activation pathway mediated by this channel by binding to the charge-rich outer pore region (in an activated state) (By similarity).
messages: Interacts with PIRT (By similarity). Homotetramer. May also form a heteromeric channel with TRPV3. Interacts with CALM, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity). Interacts with the Scolopendra mutilans RhTx toxin (By similarity). Interacts with TMEM100 (By similarity). Interacts with PACS2 (By similarity).
messages: Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
messages: Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.
messages: Postsynaptic cell membrane
messages: The association domain (AD) is necessary for self-association.
messages: dendritic spine membrane

9615:MRAP2
gene id: 9615:MRAP2
uniprot id: A0A8C0QNL3
uniprot id: J9JHQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:RGS7BP
gene id: 9615:RGS7BP
uniprot id: A0A8C0Q3F6
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9615:HNRNPH1
gene id: 9615:HNRNPH1
uniprot id: A0A8C0MEB5
uniprot id: A0A8C0MIY8
uniprot id: A0A8I3N686
uniprot id: A0A8I3NJT6
names: Subcellular Location Annotation
messages: nucleoplasm

9615:P2RX5
gene id: 9615:P2RX5
uniprot id: A0A8I3NX68
uniprot id: A0A8P0NR95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9615:ALPL
gene id: 9615:ALPL
uniprot id: A0A8I3MZ80
uniprot id: A0A8P0TH42
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9615:PIGK
gene id: 9615:PIGK
uniprot id: A0A8C0PPF7
names: Similarity
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.

9615:TMEM45B
gene id: 9615:TMEM45B
uniprot id: A0A8I3N0V0
uniprot id: A0A8P0NCB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9615:SLC5A10
gene id: 9615:SLC5A10
uniprot id: A0A8I3P9Z1
uniprot id: A0A8P0SMD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9615:INSL3
gene id: 9615:INSL3
uniprot id: Q6X7V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: More strongly expressed in testis than in ovary.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).

9615:MOGS
gene id: 9615:MOGS
uniprot id: A0A8C0NZ98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

9615:TTC19
gene id: 9615:TTC19
uniprot id: A0A8C0M7E1
uniprot id: A0A8I3MR79
names: Similarity
messages: Belongs to the TTC19 family.

9615:FGFR2
gene id: 9615:FGFR2
uniprot id: Q9TT07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:ABL1
gene id: 9615:ABL1
uniprot id: A0A8P0SNT5
uniprot id: A0A8P0SPC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:XPO1
gene id: 9615:XPO1
uniprot id: A0A8C0NXT9
uniprot id: A0A8I3NNH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9615:ETS1
gene id: 9615:ETS1
uniprot id: A0A8C0MEX6
uniprot id: A0A8I3N088
uniprot id: A0A8I3N9R5
uniprot id: A0A8P0NUP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9615:GCNT1
gene id: 9615:GCNT1
uniprot id: A0A8C0QGH9
uniprot id: A0A8I3RY76
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9615:DTX3L
gene id: 9615:DTX3L
uniprot id: A0A8C0THL0
uniprot id: A0A8I3PVC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9615:SLC6A3
gene id: 9615:SLC6A3
uniprot id: A0A8C0MTV2
uniprot id: B6EUL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
messages: Cell membrane
messages: Membrane
messages: axon
messages: neuron projection

9615:ESCO2
gene id: 9615:ESCO2
uniprot id: A0A8P0NPE5
names: Subcellular Location Annotation
messages: Nucleus

9615:LOC481709
gene id: 9615:LOC481709
uniprot id: A0A8C0MBD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9615:LSM8
gene id: 9615:LSM8
uniprot id: A0A8C0QGD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9615:DEFB127
gene id: 9615:DEFB127
uniprot id: Q30KS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:PPIP5K1
gene id: 9615:PPIP5K1
uniprot id: A0A8C0T3G8
uniprot id: A0A8I3PM37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9615:TBL1XR1
gene id: 9615:TBL1XR1
uniprot id: A0A8C0SU26
uniprot id: A0A8I3S1H9
names: Similarity
messages: Belongs to the WD repeat EBI family.

9615:FNBP1L
gene id: 9615:FNBP1L
uniprot id: A0A8I3NR08
uniprot id: A0A8P0NR60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9615:SNTB1
gene id: 9615:SNTB1
uniprot id: A0A8C0SBM6
uniprot id: A0A8I3N923
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9615:HMGB3
gene id: 9615:HMGB3
uniprot id: A0A8C0SUV1
uniprot id: A0A8I3PS14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9615:FMNL3
gene id: 9615:FMNL3
uniprot id: A0A8C0NRQ3
uniprot id: A0A8C0NUS3
uniprot id: A0A8C0Z5I5
uniprot id: A0A8I3P3Y2
uniprot id: A0A8I3P553
names: Similarity
messages: Belongs to the formin homology family.

9615:ERO1B
gene id: 9615:ERO1B
uniprot id: A0A8C0MQI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9615:COL4A6
gene id: 9615:COL4A6
uniprot id: A0A8C0S7W3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9615:ARSH
gene id: 9615:ARSH
uniprot id: Q32KH8
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Membrane
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:DES
gene id: 9615:DES
uniprot id: Q5XFN2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylation prevents ability to form intermediate filaments.
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Homomer (PubMed:24413773). Interacts with DST (By similarity). Interacts with MTM1 (By similarity). Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament (By similarity). Interacts with CRYAB (By similarity). Interacts with NEB (via nebulin repeats 160-164) (By similarity). Interacts (via rod region) with NEBL (via nebulin repeats 1-5) (By similarity). Interacts with ASB2; the interaction targets DES for proteasomal degradation (By similarity). Interacts with PKP1 (By similarity).
messages: Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin.
messages: Nucleus
messages: Phosphorylation at Ser-7, Ser-28 and Ser-32 by CDK1, phosphorylation at Ser-60 by AURKB and phosphorylation at Thr-76 by ROCK1 contribute to efficient separation of desmin intermediate filaments during mitosis.
messages: Ubiquitination by a SCF-like complex containing ASB2 leads to proteasomal degradation.
messages: Z line
messages: sarcolemma

9615:RPS6KB1
gene id: 9615:RPS6KB1
uniprot id: A0A8C0PZC8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9615:GMPR2
gene id: 9615:GMPR2
uniprot id: A0A8C0NPE4
uniprot id: A0A8I3N2R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9615:ADAMTS10
gene id: 9615:ADAMTS10
uniprot id: A0A5F4BXP2
uniprot id: A0A8C0TL48
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:HCRTR1
gene id: 9615:HCRTR1
uniprot id: A0A8I3RSX8
uniprot id: A0A8P0P8J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:NLN
gene id: 9615:NLN
uniprot id: A0A8C0PWY4
uniprot id: A0A8I3NF09
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9615:ERF
gene id: 9615:ERF
uniprot id: A0A8C0M8B1
uniprot id: A0A8I3MC64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:NDC80
gene id: 9615:NDC80
uniprot id: A0A8C0ND51
uniprot id: A0A8I3ML90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9615:SPICE1
gene id: 9615:SPICE1
uniprot id: A0A8C0PFW6
uniprot id: A0A8I3QLX4
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

9615:LPL
gene id: 9615:LPL
uniprot id: A0A8C0TU24
uniprot id: A0A8I3Q1E8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9615:ABCA1
gene id: 9615:ABCA1
uniprot id: A0A8C0NNR5
uniprot id: A0A8I3RVS5
names: Subcellular Location Annotation
messages: Membrane

9615:SERPINB5
gene id: 9615:SERPINB5
uniprot id: A0A8C0PQP0
uniprot id: A0A8C0RVP4
uniprot id: A0A8I3MKP5
uniprot id: A0A8I3RS64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

9615:SLC5A5
gene id: 9615:SLC5A5
uniprot id: A0A8C0P3J1
uniprot id: A0A8C0S487
uniprot id: A0A8I3PS88
uniprot id: A0A8I3PWH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9615:MYCL
gene id: 9615:MYCL
uniprot id: A0A8C0SJQ9
uniprot id: A0A8I3NCJ4
uniprot id: A0A8I3NJE9
uniprot id: A0A8I3NJJ1
uniprot id: A0A8P0NNA8
uniprot id: A0A8P0PJQ1
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9615:CCL8
gene id: 9615:CCL8
uniprot id: Q68AY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity).
messages: Monomer or homodimer; in equilibrium.
messages: Secreted

9615:CHMP1A
gene id: 9615:CHMP1A
uniprot id: A0A8C0TP69
uniprot id: A0A8I3ML36
names: Similarity
messages: Belongs to the SNF7 family.

9615:CD74
gene id: 9615:CD74
uniprot id: A0A8C0S1D1
uniprot id: A0A8I3N490
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TXLNG
gene id: 9615:TXLNG
uniprot id: A0A8C0NIZ1
names: Similarity
messages: Belongs to the taxilin family.

9615:BEND6
gene id: 9615:BEND6
uniprot id: A0A8C0MGE9
uniprot id: A0A8I3NT72
uniprot id: A0A8I3S083
uniprot id: A0A8P0NS97
names: Subcellular Location Annotation
messages: Nucleus

9615:GLB1
gene id: 9615:GLB1
uniprot id: Q9TRY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 35 family.
messages: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
messages: Homodimer. May form higher multimers.
messages: Lysosome

9615:ZC3H12C
gene id: 9615:ZC3H12C
uniprot id: A0A8C0S9N9
names: Similarity
messages: Belongs to the ZC3H12 family.

9615:STT3A
gene id: 9615:STT3A
uniprot id: F1PJP5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STT3 family.
messages: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A (PubMed:12887896).
messages: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:12887896, PubMed:15835887, PubMed:25135935). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:29519914).
messages: Despite low primary sequence conservation between eukaryotic catalytic subunits and bacterial and archaeal single subunit OSTs (ssOST), structural comparison revealed several common motifs at spatially equivalent positions, like the DXD motif 1 on the external loop 1 and the DXD motif 2 on the external loop 2 involved in binding of the metal ion cofactor and the carboxamide group of the acceptor asparagine, the conserved Glu residue of the TIXE/SVSE motif on the external loop 5 involved in catalysis, as well as the WWDYG and the DK/MI motifs in the globular domain that define the binding pocket for the +2 Ser/Thr of the acceptor sequon. In bacterial ssOSTs, an Arg residue was found to interact with a negatively charged side chain at the -2 position of the sequon. This Arg is conserved in bacterial enzymes and correlates with an extended sequon requirement (Asp-X-Asn-X-Ser/Thr) for bacterial N-glycosylation.
messages: Endoplasmic reticulum membrane

9615:PEX19
gene id: 9615:PEX19
uniprot id: A0A8C0SWZ8
uniprot id: A0A8I3S7P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9615:ROPN1L
gene id: 9615:ROPN1L
uniprot id: A0A8C0TDN2
uniprot id: A0A8I3PEU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

9615:STING1
gene id: 9615:STING1
uniprot id: A0A8C0Q156
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9615:ACSL6
gene id: 9615:ACSL6
uniprot id: A0A8I3N2U1
uniprot id: A0A8I3NBT7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

9615:CASTOR1
gene id: 9615:CASTOR1
uniprot id: A0A8C0Z4H3
uniprot id: A0A8I3P8W1
names: Similarity
messages: Belongs to the GATS family.

9615:OSGEPL1
gene id: 9615:OSGEPL1
uniprot id: A0A8C0SE93
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Mitochondrion
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9615:CHRNA1
gene id: 9615:CHRNA1
uniprot id: Q9XS62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:JAK2
gene id: 9615:JAK2
uniprot id: A0A8C0QFW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system
messages: Nucleus

9615:TSC22D2
gene id: 9615:TSC22D2
uniprot id: A0A8C0S9U9
uniprot id: A0A8C0SA71
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9615:OSBPL6
gene id: 9615:OSBPL6
uniprot id: A0A8C0PAZ5
uniprot id: A0A8C0PEE8
uniprot id: A0A8C0T0U6
uniprot id: A0A8C0T2I7
uniprot id: A0A8C0T5E1
uniprot id: A0A8I3PNT4
names: Similarity
messages: Belongs to the OSBP family.

9615:CPLX1
gene id: 9615:CPLX1
uniprot id: A0A8C0QCI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9615:CDC42EP5
gene id: 9615:CDC42EP5
uniprot id: A0A8C0RAU8
uniprot id: A0A8I3MKB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9615:SIGMAR1
gene id: 9615:SIGMAR1
uniprot id: A0A8C0S1Y8
uniprot id: A0A8I3PSS1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle
messages: growth cone

9615:LHX1
gene id: 9615:LHX1
uniprot id: A0A8C0QBI9
uniprot id: A0A8I3Q2H8
names: Subcellular Location Annotation
messages: Nucleus

9615:NPR1
gene id: 9615:NPR1
uniprot id: A0A8C0RWY3
uniprot id: A0A8I3MHU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9615:ORMDL2
gene id: 9615:ORMDL2
uniprot id: A0A8C0N705
uniprot id: A0A8I3N0C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9615:ERO1A
gene id: 9615:ERO1A
uniprot id: A0A8P0TPZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9615:SRP68
gene id: 9615:SRP68
uniprot id: A0A8C0LWP4
uniprot id: Q00004
names: Caution
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6938958, PubMed:6413076). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:6938958, PubMed:6413076). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7S RNA), SRP72 binds to this complex subsequently (PubMed:8388879). The SRP complex possibly participates in the elongation arrest function (By similarity).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Heterodimer with SRP72 (PubMed:6413076, PubMed:8388879). SRP68/SRP72 heterodimer formation is stabilized by the presence of 7SL RNA (PubMed:6413076, PubMed:8388879). Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:6938958, PubMed:6413076). Within the SRP complex, interacts (via C-terminus) with SRP72 (PubMed:6413076, PubMed:8388879).
messages: Sequence encodes 9 consecutive glycine residues instead of 15 (AA 9-23).
messages: Some authors found genomic clones that have 9 or 12 consecutive glycine residues instead of 15 (AA 9-27).
messages: The N-terminus is required for RNA-binding.
messages: nucleolus

9615:SEC22A
gene id: 9615:SEC22A
uniprot id: A0A8C0TJN1
uniprot id: A0A8C0TNA5
uniprot id: A0A8I3PV59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9615:TAF1A
gene id: 9615:TAF1A
uniprot id: A0A8C0SRZ5
uniprot id: A0A8I3QXN0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9615:LOC611632
gene id: 9615:LOC611632
uniprot id: A0A8C0MV44
names: Similarity
messages: Belongs to the multicopper oxidase family.

9615:TFB1M
gene id: 9615:TFB1M
uniprot id: A0A8C0T2B3
uniprot id: A0A8I3MBK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

9615:XG
gene id: 9615:XG
uniprot id: A0A8C0YWF3
names: Similarity
messages: Belongs to the CD99 family.

9615:CAMK1D
gene id: 9615:CAMK1D
uniprot id: A0A8C0PZT9
uniprot id: A0A8I3RQN8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:TMEM106B
gene id: 9615:TMEM106B
uniprot id: A0A8C0NNS8
uniprot id: A0A8I3S576
names: Similarity
messages: Belongs to the TMEM106 family.

9615:OAS1
gene id: 9615:OAS1
uniprot id: Q2TJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9615:IL6ST
gene id: 9615:IL6ST
uniprot id: A0A8I3QGG4
uniprot id: A0A8P0PBN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9615:TPRKB
gene id: 9615:TPRKB
uniprot id: A0A8C0SRI7
uniprot id: A0A8I3P6S8
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9615:LOC609321
gene id: 9615:LOC609321
uniprot id: A0A8C0MR72
uniprot id: A0A8I3MT57
uniprot id: A0A8I3ND11
uniprot id: A0A8P0N4W4
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9615:LOC477518
gene id: 9615:LOC477518
uniprot id: Q2KM14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9615:KRT8
gene id: 9615:KRT8
uniprot id: A0A8C0PN02
names: Similarity
messages: Belongs to the intermediate filament family.

9615:COL1A1
gene id: 9615:COL1A1
uniprot id: Q9XSJ7
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibrillar collagen family.
messages: Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline.
messages: Contains mostly 4-hydroxyproline. Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: Defects in COL1A1 are a cause of osteogenesis imperfecta (OI).
messages: Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains.
messages: O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide.
messages: The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).
messages: Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts with MRC2. Interacts with TRAM2. Interacts with MFAP4 in a Ca (2+)-dependent manner.
messages: Type I collagen is a member of group I collagen (fibrillar forming collagen).
messages: extracellular matrix

9615:RPS3
gene id: 9615:RPS3
uniprot id: E2RH47
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the 40S small ribosomal subunit. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with HNRPD. Interacts with PRMT1; the interaction methylates RPS3. Interacts with SUMO1; the interaction sumoylates RPS3. Interacts with UBC9. Interacts with CDK1; the interaction phosphorylates RPS3. Interacts with PRKCD; the interaction phosphorylates RPS3. Interacts with PKB/AKT; the interaction phosphorylates RPS3. Interacts with E2F1; the interaction occurs in the absence of nerve growth factor and increases transcription of pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with the base excision repair proteins APEX1 and OGG1; interaction with OGG1 increases OGG1 N-glycosylase activity. Interacts with UNG; the interaction increases the uracil excision activity of UNG1. Interacts with HSP90; the interaction prevents the ubiquitination and proteasome-dependent degradation of RPS3 and is suppressed by increased ROS levels. Interacts with TOM70; the interaction promotes translocation of RPS3 to the mitochondrion. Interacts (via N-terminus) with RELA (via N-terminus); the interaction enhances the DNA-binding activity of the NF-kappa-B p65-p50 complex. Interacts with NFKBIA; the interaction is direct and may bridge the interaction between RPS3 and RELA. Interacts with IKKB; the interaction phosphorylates RPS3 and enhances its translocation to the nucleus. Interacts (via KH domain) with MDM2 and TP53. Interacts with TRADD. Interacts with CRY1.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein OGG1. Enhances the uracil excision activity of UNG1. Also stimulates the cleavage of the phosphodiester backbone by APEX1. When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide. Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes. Represses its own translation by binding to its cognate mRNA. Binds to and protects TP53/p53 from MDM2-mediated ubiquitination. Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization. Involved in induction of apoptosis through its role in activation of CASP8. Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation.
messages: Cytoplasm
messages: Methylation by PRMT1 is required for import into the nucleolus and for ribosome assembly.
messages: Mitochondrion inner membrane
messages: Nucleus
messages: Phosphorylation at Thr-221 by CDK1 occurs mainly in G2/M phase. Phosphorylation by PRKCD occurs on a non-ribosomal-associated form which results in translocation of RPS3 to the nucleus and enhances its endonuclease activity. Phosphorylated on Ser-209 by IKKB in response to activation of the NF-kappa-B p65-p50 complex which enhances the association of RPS3 with importin-alpha and mediates the nuclear translocation of RPS3. Phosphorylation by MAPK is required for translocation to the nucleus following exposure of cells to DNA damaging agents such as hydrogen peroxide. Phosphorylation by PKB/AKT mediates RPS3 nuclear translocation, enhances RPS3 endonuclease activity and suppresses RPS3-induced neuronal apoptosis.
messages: Sumoylation by SUMO1 enhances protein stability through increased resistance to proteolysis. Sumoylation occurs at one or more of the three consensus sites, Lys-18, Lys-214 and Lys-230.
messages: Ubiquitinated; ubiquitination is prevented by interaction with HSP90 which stabilizes the protein. Monoubiquitinated at Lys-214 by RNF10 and ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide. Deubiquitinated at Lys-214 by USP10, preventing degradation by the proteasome and promoting 40S ribosome subunit recycling following ribosome dissociation.
messages: Ufmylated by UFL1.
messages: nucleolus
messages: spindle

9615:PRF1
gene id: 9615:PRF1
uniprot id: C5IY80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9615:PLOD3
gene id: 9615:PLOD3
uniprot id: A0A8I3MZE0
uniprot id: A0A8P0SIG0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9615:LOC100688081
gene id: 9615:LOC100688081
uniprot id: P86218
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
messages: Specific component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:15835887). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:15835887, PubMed:29519914). Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex (By similarity).

9615:WNT9B
gene id: 9615:WNT9B
uniprot id: A0A8I3PG82
uniprot id: A0A8P0STL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9615:IL26
gene id: 9615:IL26
uniprot id: A0A8C0TGM1
uniprot id: F6Y6M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9615:C12H6orf89
gene id: 9615:C12H6orf89
uniprot id: A0A8C0T6T3
uniprot id: A0A8I3N4H8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9615:MELK
gene id: 9615:MELK
uniprot id: A0A8C0MM54
uniprot id: A0A8I3NCR5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9615:POLR3H
gene id: 9615:POLR3H
uniprot id: A0A8C0SX43
uniprot id: A0A8C0SY15
uniprot id: A0A8I3P155
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9615:SLIT2
gene id: 9615:SLIT2
uniprot id: A0A8C0LX73
uniprot id: A0A8I3NDC9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:NONO
gene id: 9615:NONO
uniprot id: A0A8C0NGA6
names: Subcellular Location Annotation
messages: Nucleus speckle

9615:ACBD5
gene id: 9615:ACBD5
uniprot id: A0A8I3MIL3
uniprot id: A0A8I3MPJ0
uniprot id: A0A8P0N729
uniprot id: A0A8P0T9X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

9615:POLH
gene id: 9615:POLH
uniprot id: A0A8I3N3K2
uniprot id: A0A8P0N518
names: Subcellular Location Annotation
messages: Nucleus

9615:USP20
gene id: 9615:USP20
uniprot id: A0A8I3S6H8
uniprot id: A0A8P0NL07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9615:PLG
gene id: 9615:PLG
uniprot id: A0A8C0N481
uniprot id: A0A8I3MF27
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
messages: Secreted

9615:STPG4
gene id: 9615:STPG4
uniprot id: A0A8C0MWS2
uniprot id: A0A8I3MX65
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:MRPL1
gene id: 9615:MRPL1
uniprot id: A0A8C0NYA7
uniprot id: A0A8I3NXX0
names: Subcellular Location Annotation
messages: Mitochondrion

9615:FLT3
gene id: 9615:FLT3
uniprot id: Q4ZHV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:CHRM4
gene id: 9615:CHRM4
uniprot id: A0A8C0SJA8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9615:NIF3L1
gene id: 9615:NIF3L1
uniprot id: A0A8C0TGA9
uniprot id: A0A8I3QK70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9615:TPT1
gene id: 9615:TPT1
uniprot id: A0A8C0SSK0
uniprot id: A0A8I3N0W8
names: Similarity
messages: Belongs to the TCTP family.

9615:TTC21B
gene id: 9615:TTC21B
uniprot id: A0A8C0TNR8
uniprot id: A0A8I3NWC8
names: Similarity
messages: Belongs to the TTC21 family.

9615:GNL2
gene id: 9615:GNL2
uniprot id: A0A8P0S994
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

9615:FAM167B
gene id: 9615:FAM167B
uniprot id: A0A8P0NCN3
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9615:RHBDD2
gene id: 9615:RHBDD2
uniprot id: A0A8C0SHN3
uniprot id: A0A8I3MSQ4
names: Subcellular Location Annotation
messages: Membrane

9615:DUSP10
gene id: 9615:DUSP10
uniprot id: A0A8C0PG26
uniprot id: A0A8I3Q914
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9615:FAM162A
gene id: 9615:FAM162A
uniprot id: A0A8C0Z4J8
uniprot id: A0A8I3PIY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9615:PGD
gene id: 9615:PGD
uniprot id: A0A8C0P5E9
uniprot id: A0A8I3MQ54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9615:LOC102153143
gene id: 9615:LOC102153143
uniprot id: A0A8C0P4T4
uniprot id: A0A8I3PLS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

9615:NASP
gene id: 9615:NASP
uniprot id: A0A8C0NKP0
uniprot id: A0A8C0NQJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

9615:DHX29
gene id: 9615:DHX29
uniprot id: A0A8C0PNU9
uniprot id: A0A8I3PSZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

9615:BMP2
gene id: 9615:BMP2
uniprot id: A0A8I3PXE9
uniprot id: A0A8P0T128
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9615:CHST4
gene id: 9615:CHST4
uniprot id: A0A8I3RSR6
uniprot id: A0A8P0NLD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9615:MARK3
gene id: 9615:MARK3
uniprot id: A0A8C0M1W0
uniprot id: A0A8C0RAD5
uniprot id: A0A8I3PCB6
uniprot id: A0A8I3PDX9
uniprot id: A0A8I3S0L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9615:SUPT4H1
gene id: 9615:SUPT4H1
uniprot id: A0A8C0PR08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9615:MT4
gene id: 9615:MT4
uniprot id: Q9TUI5
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia (By similarity).

9615:ACLY
gene id: 9615:ACLY
uniprot id: A0A8C0NV54
uniprot id: A0A8C0S3J8
uniprot id: A0A8I3NHY9
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9615:COX6A2
gene id: 9615:COX6A2
uniprot id: A0A8C0RC68
uniprot id: A0A8I3NIL8
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6A family.

9615:LPAR1
gene id: 9615:LPAR1
uniprot id: A0A8C0RGT5
uniprot id: A0A8I3NQV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

9615:BLMH
gene id: 9615:BLMH
uniprot id: A0A8C0Q1A1
uniprot id: A0A8I3NNT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9615:SOAT1
gene id: 9615:SOAT1
uniprot id: A0A8I3N1B2
uniprot id: A0A8I3N2Z1
uniprot id: A0A8P0NFS6
uniprot id: A0A8P0SX12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:AARS2
gene id: 9615:AARS2
uniprot id: A0A8C0SB15
uniprot id: A0A8I3NJ93
names: Caution
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9615:SOX3
gene id: 9615:SOX3
uniprot id: A0A8C0SIP7
names: Subcellular Location Annotation
messages: Nucleus

9615:VPS52
gene id: 9615:VPS52
uniprot id: Q5TJF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
messages: Belongs to the VPS52 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin. EIPR1 interacts with both EARP and GARP complexes and mediates the recruitment of the GARP complex to the trans-Golgi network. Interacts with RAB6A and STX10. Interacts with BLTP3B.
messages: Endosome membrane
messages: Recycling endosome
messages: trans-Golgi network membrane

9615:KCNS3
gene id: 9615:KCNS3
uniprot id: A0A8C0N799
uniprot id: A0A8I3P439
names: Subcellular Location Annotation
messages: Membrane

9615:MRPL11
gene id: 9615:MRPL11
uniprot id: A0A8C0NPB5
uniprot id: A0A8I3NQ30
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9615:RABAC1
gene id: 9615:RABAC1
uniprot id: Q8HY39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA1 family.
messages: Cell membrane
messages: Cytoplasm
messages: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1.
messages: Golgi apparatus
messages: Homodimer. Interacts with VAMP2 (synaptobrevin-2), prenylated Rab proteins, GDI1, NDRG1 and PCLO (By similarity).
messages: synaptic vesicle

9615:LOC611458
gene id: 9615:LOC611458
uniprot id: A0A8P0NTM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9615:PPP4C
gene id: 9615:PPP4C
uniprot id: A0A8C0SWJ4
uniprot id: A0A8I3MJ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9615:AKAP12
gene id: 9615:AKAP12
uniprot id: A0A8C0STI4
uniprot id: A0A8C0STP0
uniprot id: A0A8C0SUQ5
names: Subcellular Location Annotation
messages: Membrane

9615:BIRC5
gene id: 9615:BIRC5
uniprot id: Q8I009
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-129 results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.
messages: Belongs to the IAP family.
messages: Chromosome
messages: Cytoplasm
messages: In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities. Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity. Phosphorylation at Ser-20 by AURKC is critical for regulation of proper chromosome alignment and segregation, and possibly cytokinesis.
messages: Midbody
messages: Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8. Interacts with JTB. Interacts (via BIR domain) with histone H3 phosphorylated at 'Thr-3' (H3pT3). Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce. Interacts with FBXL7; this interaction facilitates the polyubiquitination and subsequent proteasomal degradation of BIRC5 by the SCF(FBXL7) E3 ubiquitin-protein ligase complex (By similarity).
messages: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity).
messages: Nucleus
messages: The BIR repeat is necessary and sufficient for LAMTOR5 binding.
messages: Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting. Deubiquitinated by USP35 or USP38; leading to stabilization.
messages: centromere
messages: kinetochore
messages: spindle

9615:TNFSF13B
gene id: 9615:TNFSF13B
uniprot id: C4NZX1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9615:TBX6
gene id: 9615:TBX6
uniprot id: A0A8C0LX63
uniprot id: A0A8I3RRQ7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:DLGAP4
gene id: 9615:DLGAP4
uniprot id: A0A8C0SBK2
uniprot id: A0A8C0YWB0
uniprot id: A0A8I3PW67
names: Similarity
messages: Belongs to the SAPAP family.

9615:NAA11
gene id: 9615:NAA11
uniprot id: A0A8C0RLN5
uniprot id: A0A8I3P5T4
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9615:MFF
gene id: 9615:MFF
uniprot id: A0A8C0RSA8
uniprot id: A0A8C0T8B9
uniprot id: A0A8C0T959
uniprot id: A0A8C0T9J3
uniprot id: A0A8C0TA42
uniprot id: A0A8C0TDE9
uniprot id: A0A8I3NPG0
uniprot id: A0A8I3NPX4
uniprot id: A0A8I3NU68
uniprot id: A0A8I3P780
uniprot id: A0A8P0T8M4
uniprot id: A0A8P0TCJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
messages: synaptic vesicle

9615:SNCA
gene id: 9615:SNCA
uniprot id: A0A8C0PHH6
uniprot id: A0A8I3PAH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse
messages: axon

9615:LDHA
gene id: 9615:LDHA
uniprot id: A0A8C0RS21
uniprot id: A0A8P0NBD5
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9615:LOC476620
gene id: 9615:LOC476620
uniprot id: A0A8C0N3S2
uniprot id: A0A8I3PGL7
names: Similarity
messages: Belongs to the actin family.

9615:LXN
gene id: 9615:LXN
uniprot id: A0A8C0P2S3
uniprot id: A0A8I3PT76
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9615:LYRM9
gene id: 9615:LYRM9
uniprot id: A0A8C0NB24
uniprot id: A0A8I3NK00
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

9615:RTRAF
gene id: 9615:RTRAF
uniprot id: A0A8C0Q1F7
uniprot id: A0A8I3MKM6
names: Similarity
messages: Belongs to the RTRAF family.

9615:GGPS1
gene id: 9615:GGPS1
uniprot id: A0A8C0MJC7
uniprot id: A0A8I3MQD1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9615:CASP4
gene id: 9615:CASP4
uniprot id: Q9MZV7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cell membrane
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NLRP2 and whose function would be the activation of pro-inflammatory caspases. Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis). Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17P/INCA and CARD18. Interacts with SERPINB1; this interaction regulates CASP1 activity.
messages: The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
messages: Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly.
messages: Ubiquitinated via 'Lys-11'-linked polyubiquitination. Deubiquitinated by USP8.

9615:LOC606845
gene id: 9615:LOC606845
uniprot id: A0A8C0NKV1
uniprot id: A0A8I3MPI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9615:GPR55
gene id: 9615:GPR55
uniprot id: A0A8P0PK19
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:ATP6V1G2
gene id: 9615:ATP6V1G2
uniprot id: Q5WR09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).

9615:NRDC
gene id: 9615:NRDC
uniprot id: A0A8C0S4K6
names: Similarity
messages: Belongs to the peptidase M16 family.

9615:CDC34
gene id: 9615:CDC34
uniprot id: A0A8C0SC16
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:ZP3
gene id: 9615:ZP3
uniprot id: P48831
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Expressed in oocytes.
messages: N-glycosylated.
messages: O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.
messages: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers. Interacts with ZP1 and ZP2.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9615:FAM199X
gene id: 9615:FAM199X
uniprot id: A0A8I3NYW9
uniprot id: A0A8P0SM27
names: Similarity
messages: Belongs to the FAM199 family.

9615:TIMM17A
gene id: 9615:TIMM17A
uniprot id: A0A8C0PZD9
uniprot id: A0A8I3P841
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9615:CNTNAP4
gene id: 9615:CNTNAP4
uniprot id: A0A8C0M4P1
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CNPY1
gene id: 9615:CNPY1
uniprot id: A0A8I3NKM6
uniprot id: A0A8P0TU64
names: Similarity
messages: Belongs to the canopy family.

9615:TIMP3
gene id: 9615:TIMP3
uniprot id: A0A8C0MG55
uniprot id: F5CBP3
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9615:CYP3A26
gene id: 9615:CYP3A26
uniprot id: Q8HZK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:MRPS16
gene id: 9615:MRPS16
uniprot id: A0A8P0PHL1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9615:CD164
gene id: 9615:CD164
uniprot id: A0A8C0MRV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9615:DGKE
gene id: 9615:DGKE
uniprot id: A0A8C0MX95
uniprot id: A0A8I3PA16
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9615:KRT5
gene id: 9615:KRT5
uniprot id: A0A8C0P4P0
names: Similarity
messages: Belongs to the intermediate filament family.

9615:C1S
gene id: 9615:C1S
uniprot id: A0A8C0TNV8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:LOC102153873
gene id: 9615:LOC102153873
uniprot id: A0A8C0SPB5
uniprot id: A0A8I3QMQ6
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9615:HACD1
gene id: 9615:HACD1
uniprot id: Q4W1W1
names: Caution
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Defects in HACD1 may be the cause of autosomal recessive centronuclear myopathy in Labradors.
messages: Endoplasmic reticulum membrane
messages: May interact with enzymes of the ELO family (including ELOVL1); with those enzymes that mediate condensation, the first of the four steps of the reaction cycle responsible for fatty acids elongation, may be part of a larger fatty acids elongase complex.
messages: Shares some similarity with tyrosine phosphatase proteins but it has no phosphatase activity.
messages: Skeletal muscle.

9615:RECQL
gene id: 9615:RECQL
uniprot id: A0A8C0TTS5
uniprot id: A0A8I3NQI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9615:KRT40
gene id: 9615:KRT40
uniprot id: A0A8C0SF78
uniprot id: A0A8I3NSM8
names: Similarity
messages: Belongs to the intermediate filament family.

9615:RTBDN
gene id: 9615:RTBDN
uniprot id: Q4TUC0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folate receptor family.
messages: Cell membrane
messages: Not N-glycosylated.
messages: Riboflavin-binding protein which might have a role in retinal flavin transport.
messages: interphotoreceptor matrix

9615:ASZ1
gene id: 9615:ASZ1
uniprot id: A0A8C0N4W1
uniprot id: A0A8I3RUV9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9615:SEBOX
gene id: 9615:SEBOX
uniprot id: A0A8C0T9W0
uniprot id: A0A8I3N016
names: Subcellular Location Annotation
messages: Nucleus

9615:CCL1
gene id: 9615:CCL1
uniprot id: Q68AY8
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9615:PHACTR3
gene id: 9615:PHACTR3
uniprot id: A0A8C0TA75
uniprot id: A0A8I3NU15
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9615:FAM83A
gene id: 9615:FAM83A
uniprot id: A0A8C0SHB9
uniprot id: A0A8I3N6W9
names: Similarity
messages: Belongs to the FAM83 family.

9615:RORB
gene id: 9615:RORB
uniprot id: A0A8C0PBT3
uniprot id: A0A8I3NN50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9615:DEFB121
gene id: 9615:DEFB121
uniprot id: A0A8C0TG73
uniprot id: Q30KT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:C5H16orf70
gene id: 9615:C5H16orf70
uniprot id: A0A8C0T4D2
names: Similarity
messages: Belongs to the PHAF1 family.

9615:CLIC2
gene id: 9615:CLIC2
uniprot id: A0A8C0TF26
uniprot id: A0A8I3P560
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9615:OR4S7
gene id: 9615:OR4S7
uniprot id: A0A8C0RD89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:DYNC1I2
gene id: 9615:DYNC1I2
uniprot id: A0A8C0TWM4
uniprot id: A0A8I3PUW6
uniprot id: A0A8I3PY97
uniprot id: A0A8P0SHL5
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9615:MMUT
gene id: 9615:MMUT
uniprot id: A0A8C0MC30
uniprot id: A0A8I3NEF1
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

9615:FLT1
gene id: 9615:FLT1
uniprot id: A0A8C0NYS8
uniprot id: A0A8I3PN58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:UCP3
gene id: 9615:UCP3
uniprot id: Q9N2I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with HAX1; the interaction is direct and calcium-dependent.
messages: Mitochondrion inner membrane
messages: Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism. Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis. However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity.

9615:ELF4
gene id: 9615:ELF4
uniprot id: A0A8C0TE87
uniprot id: A0A8I3Q642
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:OR51T1
gene id: 9615:OR51T1
uniprot id: A0A8C0NS58
uniprot id: F1PUC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SMAD7
gene id: 9615:SMAD7
uniprot id: A0A8C0LW86
uniprot id: A0A8I3P368
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9615:LRRC8E
gene id: 9615:LRRC8E
uniprot id: A0A8C0T6L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9615:WDR4
gene id: 9615:WDR4
uniprot id: A0A8C0TVZ5
uniprot id: A0A8I3NY53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat TRM82 family.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

9615:DLD
gene id: 9615:DLD
uniprot id: P49819
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer. Part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (subunits PDHA (PDHA1 or PDHA2) and PDHB, E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (by non covalent bonds). The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A. Interacts with PDHX.
messages: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease (By similarity). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: The active site is a redox-active disulfide bond.
messages: Tyrosine phosphorylated.
messages: acrosome
messages: flagellum

9615:RPL34
gene id: 9615:RPL34
uniprot id: A0A5F4D4Q9
uniprot id: A0A8C0PL86
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9615:LOC106560070
gene id: 9615:LOC106560070
uniprot id: A0A8C0NN23
uniprot id: A0A8I3PXF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:C34H3orf70
gene id: 9615:C34H3orf70
uniprot id: A0A8C0Z6U6
uniprot id: A0A8I3Q3W8
names: Similarity
messages: Belongs to the UPF0524 family.

9615:SERPINA11
gene id: 9615:SERPINA11
uniprot id: A0A8C0MUN0
uniprot id: A0A8I3RSL1
names: Similarity
messages: Belongs to the serpin family.

9615:ZIC3
gene id: 9615:ZIC3
uniprot id: A0A8I3Q6K6
uniprot id: A0A8P0SMN0
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9615:THRAP3
gene id: 9615:THRAP3
uniprot id: A0A8C0P4V2
uniprot id: A0A8I3QB39
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9615:HSP90B1
gene id: 9615:HSP90B1
uniprot id: P41148
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the heat shock protein 90 family.
messages: Detected in heart muscle (at protein level).
messages: Endoplasmic reticulum lumen
messages: Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9 (By similarity). Interacts with CNPY3; this interaction is disrupted in the presence of ATP. Interacts with several TLRs, including TLR4 and TLR9, but not with TLR3 (By similarity). Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with METTL23 (By similarity). Interacts with IL1B; the interaction facilitates cargo translocation into the ERGIC (By similarity).
messages: Melanosome
messages: Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity (PubMed:17936703). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity).
messages: Phosphorylated by CK2.
messages: Sarcoplasmic reticulum lumen

9615:ADRB3
gene id: 9615:ADRB3
uniprot id: O02662
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
messages: Cell membrane
messages: Interacts with ARRDC3.

9615:GRB14
gene id: 9615:GRB14
uniprot id: A0A8I3NWV9
uniprot id: A0A8P0NCU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9615:DLL4
gene id: 9615:DLL4
uniprot id: A0A8C0TZ79
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9615:RHPN2
gene id: 9615:RHPN2
uniprot id: Q8HXG3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RHPN family.
messages: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity).
messages: By thyrotropin (TSH).
messages: Interacts with GTP-bound RhoA and RhoB. Interacts with both GTP- and GDP-bound RhoA. Interacts with KRT18 (By similarity).
messages: Mainly expressed in thyroid.
messages: perinuclear region

9615:TSSK6
gene id: 9615:TSSK6
uniprot id: A0A8C0N7A6
uniprot id: A0A8I3S0T7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:DIPK1B
gene id: 9615:DIPK1B
uniprot id: A0A8C0MEF9
uniprot id: A0A8I3MZ75
names: Similarity
messages: Belongs to the DIPK family.

9615:LOC609902
gene id: 9615:LOC609902
uniprot id: A0A8C0T824
names: Similarity
messages: Belongs to the FAM133 family.

9615:BLOC1S5
gene id: 9615:BLOC1S5
uniprot id: A0A8C0N2S7
uniprot id: A0A8C0SNH0
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

9615:RNMT
gene id: 9615:RNMT
uniprot id: A0A8C0SFE4
uniprot id: A0A8I3RRE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9615:PHF20L1
gene id: 9615:PHF20L1
uniprot id: A0A8I3N833
uniprot id: A0A8P0N4B0
names: Subcellular Location Annotation
messages: Nucleus

9615:PRPF18
gene id: 9615:PRPF18
uniprot id: A0A8C0RL20
uniprot id: A0A8C0RL30
uniprot id: A0A8I3NP29
uniprot id: A0A8I3NZU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

9615:CTSD
gene id: 9615:CTSD
uniprot id: Q4LAL9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.
messages: Belongs to the peptidase A1 family.
messages: Consists of a light chain and a heavy chain. Interacts with ADAM30; this leads to activation of CTSD. Interacts with GRN; stabilizes CTSD; increases its proteolytic activity (By similarity).
messages: Lysosome
messages: Melanosome
messages: N- and O-glycosylated.
messages: Undergoes proteolytic cleavage and activation by ADAM30.
messages: extracellular space

9615:LOC100686522
gene id: 9615:LOC100686522
uniprot id: A0A8C0TRG8
uniprot id: A0A8I3S501
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9615:UGP2
gene id: 9615:UGP2
uniprot id: A0A8C0Q2E5
uniprot id: A0A8I3S420
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9615:OGFOD1
gene id: 9615:OGFOD1
uniprot id: A0A8C0MFM2
uniprot id: A0A8I3MQV7
names: Similarity
messages: Belongs to the TPA1 family.

9615:IL1RAPL1
gene id: 9615:IL1RAPL1
uniprot id: A0A8C0SAK0
uniprot id: A0A8I3QQB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: Cell membrane
messages: axon
messages: dendrite

9615:NPTX2
gene id: 9615:NPTX2
uniprot id: A0A8P0NH47
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:NPC2
gene id: 9615:NPC2
uniprot id: A0A8C0P355
uniprot id: A0A8I3NVN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9615:MSN
gene id: 9615:MSN
uniprot id: A0A8C0TCI6
uniprot id: A0A8C0Z3D7
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9615:LOC102151792
gene id: 9615:LOC102151792
uniprot id: A0A8I3MFN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

9615:SLC13A5
gene id: 9615:SLC13A5
uniprot id: A0A8C0RNQ2
uniprot id: A0A8I3MEW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9615:YIPF1
gene id: 9615:YIPF1
uniprot id: A0A8C0M925
uniprot id: A0A8I3NX89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9615:GLS2
gene id: 9615:GLS2
uniprot id: A0A8C0QF91
uniprot id: A0A8I3N750
names: Similarity
messages: Belongs to the glutaminase family.

9615:CAPZA2
gene id: 9615:CAPZA2
uniprot id: A0M8V0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). Directly interacts with CRACD; this interaction decreases binding to actin (By similarity).

9615:RPL15
gene id: 9615:RPL15
uniprot id: E2QXF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. Interacts with IFIT1 (via TPR repeats 1-4).
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9615:NDUFA5
gene id: 9615:NDUFA5
uniprot id: A0A8I3MYH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:KARS1
gene id: 9615:KARS1
uniprot id: A0A8C0LY80
uniprot id: A0A8C0S9F2
uniprot id: A0A8I3PI46
uniprot id: A0A8I3S6W4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9615:RENBP
gene id: 9615:RENBP
uniprot id: A0A8C0Z2M0
uniprot id: A0A8I3PZF2
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

9615:GTF2E1
gene id: 9615:GTF2E1
uniprot id: A0A8C0T8L9
uniprot id: A0A8I3P9H5
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

9615:NR4A2
gene id: 9615:NR4A2
uniprot id: A0A8C0MMA8
uniprot id: A0A8C0YX67
uniprot id: A0A8I3PJX5
uniprot id: A0A8I3PXP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9615:WARS2
gene id: 9615:WARS2
uniprot id: A0A8C0YY21
uniprot id: A0A8I3MZ22
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:CTSS
gene id: 9615:CTSS
uniprot id: A0A8C0MLX9
uniprot id: Q8HY81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Secreted
messages: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
messages: phagosome

9615:DSE
gene id: 9615:DSE
uniprot id: A0A8C0Q4B7
uniprot id: A0A8I3MZW8
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9615:CEP76
gene id: 9615:CEP76
uniprot id: A0A8C0S8L9
uniprot id: A0A8C0YVE2
uniprot id: A0A8I3MY16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP76 family.
messages: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
messages: centriole

9615:FABP9
gene id: 9615:FABP9
uniprot id: A0A8C0T517
uniprot id: A0A8I3NVA3
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9615:MX1
gene id: 9615:MX1
uniprot id: Q9N0Y3
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: By type I and type III interferons.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).
messages: ISGylated.
messages: Interferon-induced dynamin-like GTPase with antiviral activity.
messages: The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.
messages: The middle domain mediates self-assembly and oligomerization.
messages: perinuclear region

9615:IRAK4
gene id: 9615:IRAK4
uniprot id: A0A8I3S726
uniprot id: A0A8P0T666
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9615:TM4SF5
gene id: 9615:TM4SF5
uniprot id: A0A8C0MPX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9615:EGR3
gene id: 9615:EGR3
uniprot id: A0A8C0RPM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9615:SLC39A1
gene id: 9615:SLC39A1
uniprot id: A0A8C0P1C3
uniprot id: A0A8I3P500
names: Subcellular Location Annotation
messages: Membrane

9615:NSMCE1
gene id: 9615:NSMCE1
uniprot id: A0A8C0P8T4
uniprot id: A0A8I3N8D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9615:EIF1AD
gene id: 9615:EIF1AD
uniprot id: A0A8C0NT14
uniprot id: A0A8I3S0Q1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9615:PIWIL4
gene id: 9615:PIWIL4
uniprot id: A0A8P0S9T3
names: Similarity
messages: Belongs to the argonaute family.

9615:GABBR2
gene id: 9615:GABBR2
uniprot id: A0A8C0MC19
uniprot id: A0A8I3MTR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:L3MBTL2
gene id: 9615:L3MBTL2
uniprot id: A0A8C0T329
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

9615:NCBP3
gene id: 9615:NCBP3
uniprot id: A0A8C0MSZ4
uniprot id: A0A8I3RZM9
uniprot id: A0A8I3S2H3
uniprot id: A0A8P0PIY7
names: Similarity
messages: Belongs to the NCBP3 family.

9615:NUDT3
gene id: 9615:NUDT3
uniprot id: A0A8C0SB44
uniprot id: A0A8I3PT27
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9615:FAM149B1
gene id: 9615:FAM149B1
uniprot id: A0A8C0RV42
uniprot id: A0A8C0RVA3
uniprot id: A0A8I3MYX7
names: Similarity
messages: Belongs to the FAM149 family.

9615:DCTN2
gene id: 9615:DCTN2
uniprot id: A0A8C0MVC7
uniprot id: A0A8C0SNF5
uniprot id: A0A8I3NKR5
uniprot id: A0A8I3RWZ8
names: Similarity
messages: Belongs to the dynactin subunit 2 family.

9615:KDELR2
gene id: 9615:KDELR2
uniprot id: A0A8C0YYB5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:GPRC6A
gene id: 9615:GPRC6A
uniprot id: A0A8C0RWS0
uniprot id: A0A8I3MQB9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:SCNN1A
gene id: 9615:SCNN1A
uniprot id: A0A8C0PLX6
names: Subcellular Location Annotation
messages: Membrane

9615:NTMT1
gene id: 9615:NTMT1
uniprot id: A0A8C0YS23
uniprot id: A0A8I3PWP8
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9615:ATXN7L3
gene id: 9615:ATXN7L3
uniprot id: A0A8C0YZW6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.
messages: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

9615:SPARCL1
gene id: 9615:SPARCL1
uniprot id: A0A8C0TSG0
uniprot id: A0A8C0TWR3
uniprot id: A0A8I3NXP5
uniprot id: A0A8I3RYX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9615:DDA1
gene id: 9615:DDA1
uniprot id: A0A8C0P4U1
names: Similarity
messages: Belongs to the DDA1 family.

9615:UBE2L6
gene id: 9615:UBE2L6
uniprot id: A0A8C0SL13
uniprot id: A0A8I3PAX4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:CPS1
gene id: 9615:CPS1
uniprot id: A0A8C0SJY9
uniprot id: A0A8I3P9N3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SCN5A
gene id: 9615:SCN5A
uniprot id: Q865W3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9615:PRDX1
gene id: 9615:PRDX1
uniprot id: A0A8C0SYI9
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9615:CCDC181
gene id: 9615:CCDC181
uniprot id: A0A8C0PDX5
uniprot id: A0A8I3MT62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton

9615:SLC7A6
gene id: 9615:SLC7A6
uniprot id: A0A8I3RYK4
uniprot id: A0A8P0SP77
names: Subcellular Location Annotation
messages: Membrane

9615:ABCC11
gene id: 9615:ABCC11
uniprot id: A0A8C0MYN6
names: Subcellular Location Annotation
messages: Membrane

9615:TAS2R5
gene id: 9615:TAS2R5
uniprot id: A0A8C0QET1
uniprot id: Q2ABD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:C6H16orf91
gene id: 9615:C6H16orf91
uniprot id: A0A8C0NL66
uniprot id: A0A8I3PAI7
names: Similarity
messages: Belongs to the UQCC4 family.

9615:TMEM190
gene id: 9615:TMEM190
uniprot id: E2R0A5
names: Subcellular Location Annotation
messages: Membrane

9615:KCNH2
gene id: 9615:KCNH2
uniprot id: Q9TSZ3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
messages: Cell membrane
messages: Highly expressed in left and right atria of the heart, in cortex and hippocampus; detected at intermediate levels in left and right ventricle, Purkinje fibers, cerebellum, thalamus and basal ganglia; detected at low levels in liver, spleen and kidney.
messages: Phosphorylated on serine and threonine residues.
messages: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity).
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Interacts with DNAJB12 and DNAJB14; chaperones DNAJB12 and DNAJB14 promote tetramerization (By similarity). Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3 (By similarity). Interacts with ALG10B (By similarity). Heteromultimer with KCNE1 and KCNE2. Interacts with CANX. The core-glycosylated, but not the fully glycosylated form interacts with RNF207. Interacts with NDFIP1 and NDFIP2 (By similarity).
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

9615:AP1B1
gene id: 9615:AP1B1
uniprot id: A0A8C0T6Q2
uniprot id: A0A8I3Q4K4
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9615:CNOT9
gene id: 9615:CNOT9
uniprot id: A0A8C0TLI9
uniprot id: A0A8C0TPY0
uniprot id: A0A8I3Q1W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9615:TLX3
gene id: 9615:TLX3
uniprot id: A0A8C0PWJ0
names: Subcellular Location Annotation
messages: Nucleus

9615:GDI1
gene id: 9615:GDI1
uniprot id: O97555
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Interacts with RHOH (By similarity). Interacts with the non-phosphorylated forms of RAB1A, RAB3A, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (By similarity).
messages: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
messages: trans-Golgi network

9615:SLC25A42
gene id: 9615:SLC25A42
uniprot id: A0A8C0NCF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:ATP13A3
gene id: 9615:ATP13A3
uniprot id: A0A8C0T631
uniprot id: A0A8I3SCV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9615:NOC4L
gene id: 9615:NOC4L
uniprot id: A0A8C0P9T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Nucleus membrane

9615:EBPL
gene id: 9615:EBPL
uniprot id: A0A8I3PRC5
uniprot id: A0A8P0S9Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:SAP18
gene id: 9615:SAP18
uniprot id: A0A8C0RSG0
names: Similarity
messages: Belongs to the SAP18 family.

9615:MAP3K8
gene id: 9615:MAP3K8
uniprot id: A0A8I3N8I4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9615:ZDHHC8
gene id: 9615:ZDHHC8
uniprot id: Q2THW8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Golgi apparatus membrane
messages: Mitochondrion membrane
messages: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes. Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (By similarity). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (By similarity). Could also play a role in glutamatergic transmission (By similarity).
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:NDUFB6
gene id: 9615:NDUFB6
uniprot id: A0A8C0QJI5
uniprot id: A0A8I3P9N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:FUT11
gene id: 9615:FUT11
uniprot id: A0A8C0PRC0
uniprot id: A0A8I3RVW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9615:CENPT
gene id: 9615:CENPT
uniprot id: A0A8C0NTF8
uniprot id: A0A8I3MYA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus
messages: kinetochore

9615:GPBP1
gene id: 9615:GPBP1
uniprot id: A0A8P0NS49
uniprot id: A0A8P0SCD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9615:SLC50A1
gene id: 9615:SLC50A1
uniprot id: A0A8C0PI33
uniprot id: A0A8C0PQD3
uniprot id: A0A8I3NJZ7
uniprot id: A0A8I3NSG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

9615:QSOX2
gene id: 9615:QSOX2
uniprot id: A0A8P0TN97
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

9615:B4GALNT1
gene id: 9615:B4GALNT1
uniprot id: A0A8C0YZS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:LOC100688842
gene id: 9615:LOC100688842
uniprot id: A0A8C0N2U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9615:LRP6
gene id: 9615:LRP6
uniprot id: A0A8C0NS55
uniprot id: A0A8I3Q1I5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TPRA1
gene id: 9615:TPRA1
uniprot id: A0A8I3NT58
uniprot id: A0A8P0N6S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9615:COPS5
gene id: 9615:COPS5
uniprot id: A0A8C0RIF2
uniprot id: A0A8I3PK82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9615:EIF3M
gene id: 9615:EIF3M
uniprot id: A0A8C0T580
uniprot id: A0A8I3PRM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9615:PSMG1
gene id: 9615:PSMG1
uniprot id: A0A8C0PVZ6
uniprot id: A0A8I3PZN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9615:CLEC18C
gene id: 9615:CLEC18C
uniprot id: A0A8C0SNR4
uniprot id: A0A8I3MPI1
uniprot id: A0A8I3MTT6
uniprot id: A0A8P0NNG3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TTC36
gene id: 9615:TTC36
uniprot id: A0A8C0PU42
uniprot id: A0A8I3N0L1
names: Similarity
messages: Belongs to the TTC36 family.

9615:CXXC1
gene id: 9615:CXXC1
uniprot id: A0A8C0YW02
names: Subcellular Location Annotation
messages: Nucleus

9615:SMARCA5
gene id: 9615:SMARCA5
uniprot id: A0A8C0MPS3
uniprot id: A0A8I3NHW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9615:GSS
gene id: 9615:GSS
uniprot id: A0A8C0QD92
uniprot id: A0A8I3NS50
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9615:POFUT1
gene id: 9615:POFUT1
uniprot id: Q00P48
names: Similarity
messages: Belongs to the glycosyltransferase 65 family.

9615:ATP5F1B
gene id: 9615:ATP5F1B
uniprot id: A0A1B1X468
uniprot id: A0A8C0N0W7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9615:VEGFB
gene id: 9615:VEGFB
uniprot id: A0A8C0N946
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9615:MST1
gene id: 9615:MST1
uniprot id: A0A8C0T252
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:A3GALT2
gene id: 9615:A3GALT2
uniprot id: A0A8C0T5Y4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

9615:FTL
gene id: 9615:FTL
uniprot id: Q53VB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferritin family.
messages: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

9615:PAF1
gene id: 9615:PAF1
uniprot id: A0A8I3MY63
uniprot id: A0A8P0N865
names: Similarity
messages: Belongs to the PAF1 family.

9615:ITPKB
gene id: 9615:ITPKB
uniprot id: A0A8P0PQ55
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9615:NIBAN2
gene id: 9615:NIBAN2
uniprot id: A0A8C0T1Y9
names: Similarity
messages: Belongs to the Niban family.

9615:PRKACB
gene id: 9615:PRKACB
uniprot id: A0A8C0NCS8
uniprot id: A0A8C0NGV3
uniprot id: A0A8C0RJS1
uniprot id: A0A8C0SLZ6
uniprot id: A0A8I3MHE8
uniprot id: A0A8I3MJG0
uniprot id: A0A8I3N0K1
uniprot id: A0A8I3N0M1
uniprot id: A0A8P0NUA6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9615:TAF2
gene id: 9615:TAF2
uniprot id: A0A8C0MGM6
uniprot id: A0A8C0S8E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

9615:SLC35B2
gene id: 9615:SLC35B2
uniprot id: A0A8C0SAC1
uniprot id: B2BMP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9615:DEFB122
gene id: 9615:DEFB122
uniprot id: Q30KT2
uniprot id: Q863C8
uniprot id: Q863D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:CD53
gene id: 9615:CD53
uniprot id: A0A8C0SFV0
uniprot id: A0A8I3MMD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:IER5L
gene id: 9615:IER5L
uniprot id: A0A8C0MKQ4
names: Similarity
messages: Belongs to the IER family.

9615:CRKL
gene id: 9615:CRKL
uniprot id: A0A8C0TFX5
uniprot id: A0A8I3PN08
names: Similarity
messages: Belongs to the CRK family.

9615:POSTN
gene id: 9615:POSTN
uniprot id: A0A0B6VKP2
uniprot id: A0A8C0NJI6
uniprot id: A0A8C0RLU2
uniprot id: A0A8I3PQZ6
uniprot id: A0A8I3PVD8
uniprot id: A0A8I3QCL8
uniprot id: A0A8P0PCN9
names: Subcellular Location Annotation
messages: extracellular matrix

9615:SLC25A11
gene id: 9615:SLC25A11
uniprot id: A0A8C0P6K8
uniprot id: A0A8I3MM43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:EIF2AK3
gene id: 9615:EIF2AK3
uniprot id: A0A8C0SMV4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9615:MRPS5
gene id: 9615:MRPS5
uniprot id: A0A8C0QJD2
uniprot id: A0A8I3N577
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9615:ALG3
gene id: 9615:ALG3
uniprot id: A0A8C0N1J1
uniprot id: A0A8I3PWH7
uniprot id: A0A8P0NMW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:TAS1R3
gene id: 9615:TAS1R3
uniprot id: Q49HH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
messages: Cell membrane
messages: Forms homodimers or heterodimers with TAS1R1 and TAS1R2.
messages: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity).

9615:SLC25A13
gene id: 9615:SLC25A13
uniprot id: A0A8C0SP45
uniprot id: A0A8I3S503
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:AMER1
gene id: 9615:AMER1
uniprot id: A0A8C0T759
uniprot id: A0A8I3PTU0
names: Similarity
messages: Belongs to the Amer family.

9615:CCNYL1
gene id: 9615:CCNYL1
uniprot id: A0A8C0N277
uniprot id: A0A8C0TYE7
uniprot id: A0A8I3PBG6
uniprot id: A0A8I3PF40
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9615:LSM4
gene id: 9615:LSM4
uniprot id: A0A8C0NM94
uniprot id: A0A8I3PGH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9615:KRTAP8-1
gene id: 9615:KRTAP8-1
uniprot id: A0A8C0N5Q6
uniprot id: A0A8I3PD89
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9615:NDUFB10
gene id: 9615:NDUFB10
uniprot id: A0A8C0NYV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

9615:TBL1X
gene id: 9615:TBL1X
uniprot id: A0A8C0MYI5
uniprot id: A0A8I3PUV7
names: Similarity
messages: Belongs to the WD repeat EBI family.

9615:IBSP
gene id: 9615:IBSP
uniprot id: A0A8C0RTV9
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9615:PSMB4
gene id: 9615:PSMB4
uniprot id: A0A8C0MRG6
uniprot id: A0A8I3PII7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9615:DYNC1LI1
gene id: 9615:DYNC1LI1
uniprot id: A0A8C0NNW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9615:OPALIN
gene id: 9615:OPALIN
uniprot id: A0A8C0TS48
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

9615:S100A12
gene id: 9615:S100A12
uniprot id: A0A8C0RX73
uniprot id: A0A8I3MKN5
names: Similarity
messages: Belongs to the S-100 family.

9615:KRTAP24-1
gene id: 9615:KRTAP24-1
uniprot id: A0A8C0RJX5
uniprot id: A0A8I3PG96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9615:THEMIS2
gene id: 9615:THEMIS2
uniprot id: A0A8I3NU04
uniprot id: A0A8I3NU63
uniprot id: A0A8P0SGZ8
uniprot id: A0A8P0SVK8
uniprot id: A0A8P0TKM8
names: Similarity
messages: Belongs to the themis family.

9615:KCTD13
gene id: 9615:KCTD13
uniprot id: A0A8C0SR99
uniprot id: A0A8I3MGD4
names: Similarity
messages: Belongs to the BACURD family.

9615:OR56A3C
gene id: 9615:OR56A3C
uniprot id: A0A8I3N548
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:FOXS1
gene id: 9615:FOXS1
uniprot id: A0A8C0THU6
uniprot id: A0A8I3P6F2
names: Subcellular Location Annotation
messages: Nucleus

9615:ST6GALNAC6
gene id: 9615:ST6GALNAC6
uniprot id: A0A8C0N2V0
uniprot id: A0A8I3NB27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:RABGGTA
gene id: 9615:RABGGTA
uniprot id: A0A8C0RXN6
uniprot id: A0A8I3N0I7
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

9615:APOA1
gene id: 9615:APOA1
uniprot id: A0A8C0Q1U9
uniprot id: A0A8I3MSG4
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9615:CYRIB
gene id: 9615:CYRIB
uniprot id: A0A8C0Z0T8
uniprot id: A0A8I3NN08
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9615:GABRA6
gene id: 9615:GABRA6
uniprot id: A0A8C0PW20
uniprot id: A0A8I3MFI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:LOC474791
gene id: 9615:LOC474791
uniprot id: A0A8C0NV70
uniprot id: A0A8I3N3M3
names: Similarity
messages: Belongs to the NipSnap family.

9615:EBNA1BP2
gene id: 9615:EBNA1BP2
uniprot id: A0A8C0QPR6
uniprot id: A0A8I3P377
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

9615:NKD1
gene id: 9615:NKD1
uniprot id: A0A8C0SHQ4
uniprot id: A0A8I3RRS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm

9615:LOC403585
gene id: 9615:LOC403585
uniprot id: P19708
names: Disease Annotation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SAA family.
messages: Expressed by the liver; secreted in plasma.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.
messages: Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
messages: Secreted
messages: This protein is the precursor of amyloid protein A, which is formed by the removal of residues from the C-terminal end.
messages: Upon cytokine stimulation.

9615:KIF5A
gene id: 9615:KIF5A
uniprot id: A0A8C0SPT2
uniprot id: A0A8I3NMT0
uniprot id: A0A8I3NQE9
uniprot id: A0A8P0NS21
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:SULT1A1
gene id: 9615:SULT1A1
uniprot id: Q29476
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Homodimer.
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe (PubMed:12054462). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (By similarity). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
messages: Ubiquitously expressed in canine tissues with highest expression in male and female liver.

9615:CEBPG
gene id: 9615:CEBPG
uniprot id: A0A8I3MUM9
uniprot id: A0A8P0SCQ6
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

9615:RABEP2
gene id: 9615:RABEP2
uniprot id: A0A8C0Q5H1
uniprot id: A0A8I3MNR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Cytoplasm
messages: Early endosome
messages: Endosome

9615:IPO13
gene id: 9615:IPO13
uniprot id: A0A8C0NC47
uniprot id: A0A8I3Q0B0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

9615:ZBTB22
gene id: 9615:ZBTB22
uniprot id: Q5TJE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9615:MRPL50
gene id: 9615:MRPL50
uniprot id: A0A8C0RZV8
uniprot id: A0A8I3N0A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9615:BEST1
gene id: 9615:BEST1
uniprot id: A5H7G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9615:USP3
gene id: 9615:USP3
uniprot id: A0A8C0P3M4
uniprot id: A0A8C0TP90
uniprot id: A0A8I3P7J9
uniprot id: A0A8I3PGK4
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9615:FBXL15
gene id: 9615:FBXL15
uniprot id: E2RKN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBXL15 family.
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity).

9615:POLR2H
gene id: 9615:POLR2H
uniprot id: A0A8P0T3V0
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9615:DBR1
gene id: 9615:DBR1
uniprot id: A0A8C0N0N9
uniprot id: A0A8C0TNC6
uniprot id: A0A8I3PF34
uniprot id: A0A8I3PSP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

9615:BORCS5
gene id: 9615:BORCS5
uniprot id: A0A8C0TL03
uniprot id: A0A8I3PGM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9615:NKX2-2
gene id: 9615:NKX2-2
uniprot id: A0A8C0RQT7
uniprot id: A0A8I3SAT7
names: Subcellular Location Annotation
messages: Nucleus

9615:MKS1
gene id: 9615:MKS1
uniprot id: A0A8C0U0I9
uniprot id: A0A8I3NYW6
names: Subcellular Location Annotation
messages: cilium basal body

9615:TTC26
gene id: 9615:TTC26
uniprot id: A0A8C0MEA9
names: Similarity
messages: Belongs to the IFT56 family.

9615:ENTPD7
gene id: 9615:ENTPD7
uniprot id: A0A8C0NXB4
uniprot id: A0A8I3QPY0
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9615:NTF4
gene id: 9615:NTF4
uniprot id: A0A8C0PL35
uniprot id: A0A8I3MVE7
names: Similarity
messages: Belongs to the NGF-beta family.

9615:EXTL2
gene id: 9615:EXTL2
uniprot id: A0A8C0NPH0
uniprot id: A0A8C0PZY2
uniprot id: A0A8I3NG09
uniprot id: A0A8I3NML7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:FAM8A1
gene id: 9615:FAM8A1
uniprot id: A0A8C0MYT0
names: Subcellular Location Annotation
messages: Membrane

9615:E2F1
gene id: 9615:E2F1
uniprot id: A0A8C0Q8Y6
uniprot id: A0A8I3PK29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9615:OR5AC26
gene id: 9615:OR5AC26
uniprot id: A0A8C0NX46
uniprot id: A0A8I3RYZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:PARP12
gene id: 9615:PARP12
uniprot id: A0A8C0QKU4
uniprot id: A0A8I3QCN2
names: Similarity
messages: Belongs to the ARTD/PARP family.

9615:PPAN
gene id: 9615:PPAN
uniprot id: A0A8C0PFA1
uniprot id: A0A8I3S0L9
names: Subcellular Location Annotation
messages: nucleolus

9615:TRIM56
gene id: 9615:TRIM56
uniprot id: A0A8C0RRS9
uniprot id: A0A8I3MC17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9615:BCORL1
gene id: 9615:BCORL1
uniprot id: A0A8P0T5Q5
names: Similarity
messages: Belongs to the BCOR family.

9615:OGDHL
gene id: 9615:OGDHL
uniprot id: A0A8C0PAD7
uniprot id: A0A8I3PKE1
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9615:MDN1
gene id: 9615:MDN1
uniprot id: A0A8C0MTL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

9615:SSTR2
gene id: 9615:SSTR2
uniprot id: Q49LX6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain) (By similarity).
messages: Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity).
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization (By similarity).

9615:LOC485909
gene id: 9615:LOC485909
uniprot id: A0A8C0QH22
uniprot id: A0A8I3P8S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9615:PTGFR
gene id: 9615:PTGFR
uniprot id: A0A8C0SU69
uniprot id: Q45FN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:TMEM199
gene id: 9615:TMEM199
uniprot id: A0A8C0T8L1
uniprot id: A0A8I3MW30
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:COQ10B
gene id: 9615:COQ10B
uniprot id: A0A8C0MXW0
uniprot id: A0A8I3Q9W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9615:PES1
gene id: 9615:PES1
uniprot id: A0A8C0NX49
uniprot id: A0A8I3PAD8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Chromosome
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Sumoylated.
messages: nucleolus
messages: nucleoplasm

9615:ARPP19
gene id: 9615:ARPP19
uniprot id: A0A8C0TTR9
uniprot id: A0A8I3Q2L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9615:PICK1
gene id: 9615:PICK1
uniprot id: A0A8C0NFZ2
uniprot id: A0A8I3PU21
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

9615:SLC40A1
gene id: 9615:SLC40A1
uniprot id: A0A8C0NCG8
uniprot id: E2RFJ3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Cell membrane
messages: During elevated serum iron levels, liver-derived hepcidin/HAMP negatively regulates cell surface ferroportin/SLC40A1 by inducing its ubiquitination, internalization, and degradation. Indeed, hepcidin/HAMP affinity towards ferroportin/SLC40A1 increases by 80-fold in the presence of iron.
messages: Identified in a complex with STOM. Interacts with HAMP; this interaction promotes SLC40A1 rapid ubiquitination.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Manganese (Mn) transport by SLC40A1 remains controversial. Some in vitro studies have suggested that SLC40A1 transports minimal amounts of Mn(2+) (By similarity). Other groups have suggested that it does not. The affinity of SLC40A1 for manganese is extremely low compared with iron, implying that any SLC40A1-mediated Mn transport in vivo would likely be trivial (By similarity). A recent study examined the role of SLC40A1 in Mn homeostasis by using Tmprss6-O mice, which express high levels of hepcidin/HAMP and therefore have very low SLC40A1 levels in their tissues. These mice show frank iron deficiency and reduced iron levels in most tissues, but manganese levels are largely unaffected (By similarity). These studies suggest that manganese is propably not the physiological substrate of SLC40A1.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane
messages: Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (By similarity). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (By similarity).

9615:SERPINB2
gene id: 9615:SERPINB2
uniprot id: A0A8C0Q244
uniprot id: A0A8I3N109
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9615:CYP4B1
gene id: 9615:CYP4B1
uniprot id: A0A8C0YZ16
uniprot id: A0A8I3NUL1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:ATP7A
gene id: 9615:ATP7A
uniprot id: A0A8C0Z058
uniprot id: A0A8I3S4D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9615:AGER
gene id: 9615:AGER
uniprot id: Q20JV7
names: Subcellular Location Annotation
messages: Cell membrane

9615:ZYG11B
gene id: 9615:ZYG11B
uniprot id: A0A8I3S069
uniprot id: A0A8P0PEZ3
names: Similarity
messages: Belongs to the zyg-11 family.

9615:FXYD6
gene id: 9615:FXYD6
uniprot id: A0A8C0PQW8
names: Similarity
messages: Belongs to the FXYD family.

9615:ID1
gene id: 9615:ID1
uniprot id: A0A8C0TJ68
uniprot id: A0A8I3NWC0
names: Subcellular Location Annotation
messages: Nucleus

9615:TAF10
gene id: 9615:TAF10
uniprot id: A0A8C0Q3H0
uniprot id: A0A8I3N6Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.

9615:NAGA
gene id: 9615:NAGA
uniprot id: A0A8C0PJN6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9615:FAM110B
gene id: 9615:FAM110B
uniprot id: A0A8C0NMR6
uniprot id: A0A8I3QE80
names: Similarity
messages: Belongs to the FAM110 family.

9615:DCTN5
gene id: 9615:DCTN5
uniprot id: A0A8C0PXK5
uniprot id: A0A8I3MQ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

9615:SIX1
gene id: 9615:SIX1
uniprot id: A0A8C0PTN2
uniprot id: J9P3S7
names: Subcellular Location Annotation
messages: Nucleus

9615:C16H4orf47
gene id: 9615:C16H4orf47
uniprot id: A0A8C0SCD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP96 family.
messages: centrosome

9615:MYMK
gene id: 9615:MYMK
uniprot id: A0A8C0LWV2
uniprot id: A0A8I3RVZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9615:CPVL
gene id: 9615:CPVL
uniprot id: A0A8I3P2V6
uniprot id: A0A8P0P1P3
names: Similarity
messages: Belongs to the peptidase S10 family.

9615:COQ3
gene id: 9615:COQ3
uniprot id: A0A8I3MTT1
uniprot id: A0A8P0N6C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

9615:KIF3B
gene id: 9615:KIF3B
uniprot id: A0A8C0NC53
uniprot id: A0A8I3P6F1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:ABCC3
gene id: 9615:ABCC3
uniprot id: A0A8C0NRM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9615:ECRG4
gene id: 9615:ECRG4
uniprot id: A0A8C0QIA5
uniprot id: A0A8I3RWV9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9615:TMEM229B
gene id: 9615:TMEM229B
uniprot id: A0A8C0YVA9
uniprot id: A0A8I3RST6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9615:HENMT1
gene id: 9615:HENMT1
uniprot id: A0A8C0TE19
uniprot id: A0A8I3MZD3
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9615:IL18RAP
gene id: 9615:IL18RAP
uniprot id: A0A8I3RXV6
uniprot id: A0A8P0S805
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: Cell membrane

9615:ARHGEF3
gene id: 9615:ARHGEF3
uniprot id: A0A8C0PJ09
uniprot id: A0A8C0RSV7
uniprot id: A0A8I3PNP1
uniprot id: A0A8I3PQ10
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9615:PTGDR2
gene id: 9615:PTGDR2
uniprot id: Q2A652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

9615:ALOX15
gene id: 9615:ALOX15
uniprot id: A0A8C0MQI7
uniprot id: A0A8I3P5X5
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:ERN1
gene id: 9615:ERN1
uniprot id: A0A8P0NDV4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:LOC609365
gene id: 9615:LOC609365
uniprot id: A0A8C0SU15
uniprot id: A0A8C0YZN5
uniprot id: A0A8I3MKY4
uniprot id: A0A8I3MT43
uniprot id: A0A8P0PB67
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: acrosome inner membrane

9615:KRT2
gene id: 9615:KRT2
uniprot id: A0A8C0RQ12
names: Similarity
messages: Belongs to the intermediate filament family.

9615:RPS27L
gene id: 9615:RPS27L
uniprot id: A0A8C0Z4Z2
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9615:ZBED4
gene id: 9615:ZBED4
uniprot id: A0A8C0N0S8
uniprot id: A0A8I3N4E3
names: Subcellular Location Annotation
messages: Nucleus

9615:PAX1
gene id: 9615:PAX1
uniprot id: A0A8C0P7L6
uniprot id: A0A8I3Q0J6
names: Subcellular Location Annotation
messages: Nucleus

9615:FAS
gene id: 9615:FAS
uniprot id: A0A8I3Q9L2
uniprot id: A0A8P0NHD1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

9615:TOE1
gene id: 9615:TOE1
uniprot id: A0A8C0NZ09
uniprot id: A0A8I3PDS8
names: Similarity
messages: Belongs to the CAF1 family.

9615:ZDHHC22
gene id: 9615:ZDHHC22
uniprot id: A0A8C0MNF5
uniprot id: A0A8I3RUL4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:PERP
gene id: 9615:PERP
uniprot id: A0A8C0RVL1
uniprot id: A0A8I3N282
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9615:GDI2
gene id: 9615:GDI2
uniprot id: O97556
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A.
messages: Interacts with RHOH. Interacts with the GDP-bound forms of RAB3A, RAB3B, RAB3C, RAB5A, RAB5B, RAB5C, RAB8B, RAB10, RAB12, RAB35, and RAB43; binds RAB3D to a lesser extent. Interacts with RAB8A (GDP-bound inactive form); prevents RAB8A activation. Interacts with DZIP1; negatively regulates the interaction of GDI2 with GDP-bound RAB8A.
messages: Membrane

9615:RPAP1
gene id: 9615:RPAP1
uniprot id: A0A8C0TVW7
uniprot id: A0A8I3Q7V9
names: Similarity
messages: Belongs to the RPAP1 family.

9615:RRS1
gene id: 9615:RRS1
uniprot id: A0A8C0N583
uniprot id: A0A8I3P8D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9615:OR13G1
gene id: 9615:OR13G1
uniprot id: A0A8I3NAI8
uniprot id: A0A8P0NMQ1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:MTMR9
gene id: 9615:MTMR9
uniprot id: A0A8C0TH39
uniprot id: A0A8I3P9Y7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9615:PAN3
gene id: 9615:PAN3
uniprot id: A0A8I3PLB0
uniprot id: A0A8I3PNQ2
uniprot id: A0A8I3PQ88
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

9615:MITF
gene id: 9615:MITF
uniprot id: A0A8C0YSP0
uniprot id: Q864F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9615:LOC478702
gene id: 9615:LOC478702
uniprot id: A0A8I3P982
uniprot id: A0A8P0TTK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:SGCA
gene id: 9615:SGCA
uniprot id: A0A8C0SAC5
uniprot id: A0A8I3RZD4
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

9615:PIGZ
gene id: 9615:PIGZ
uniprot id: A0A8C0TXN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:FMO5
gene id: 9615:FMO5
uniprot id: A0A8C0MTQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9615:ARRB1
gene id: 9615:ARRB1
uniprot id: A0A8I3NJZ9
names: Similarity
messages: Belongs to the arrestin family.

9615:CCNG2
gene id: 9615:CCNG2
uniprot id: A0A8C0T3F8
uniprot id: A0A8I3P5A8
names: Similarity
messages: Belongs to the cyclin family.

9615:AVPR1A
gene id: 9615:AVPR1A
uniprot id: E2R8D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9615:TMX2
gene id: 9615:TMX2
uniprot id: A0A8C0MGF9
uniprot id: A0A8I3S4C8
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9615:PPP1R15A
gene id: 9615:PPP1R15A
uniprot id: A0A8I3MI88
uniprot id: A0A8P0S9J9
names: Similarity
messages: Belongs to the PPP1R15 family.

9615:EIF4EBP3
gene id: 9615:EIF4EBP3
uniprot id: A0A8C0M9J6
uniprot id: A0A8I3RRN9
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9615:POGLUT2
gene id: 9615:POGLUT2
uniprot id: A0A8C0M7A8
names: Similarity
messages: Belongs to the KDELC family.

9615:PRSS2
gene id: 9615:PRSS2
uniprot id: P06872
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: extracellular space

9615:NMI
gene id: 9615:NMI
uniprot id: A0A8C0N989
uniprot id: A0A8I3RW19
uniprot id: A0A8P0NZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9615:LOC100685565
gene id: 9615:LOC100685565
uniprot id: A0A8C0TUR6
names: Similarity
messages: Belongs to the TTC39 family.

9615:IL6R
gene id: 9615:IL6R
uniprot id: A0A8C0PF44
uniprot id: A0A8I3NUE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.
messages: Cell membrane
messages: Membrane

9615:DIPK2B
gene id: 9615:DIPK2B
uniprot id: A0A8C0SPS5
uniprot id: A0A8I3Q0Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9615:SCAMP3
gene id: 9615:SCAMP3
uniprot id: A0A8C0PGT5
uniprot id: A0A8I3NCE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9615:GPD1
gene id: 9615:GPD1
uniprot id: A0A8I3P4F4
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9615:CDKN1B
gene id: 9615:CDKN1B
uniprot id: A0A8C0NMF9
uniprot id: F1PGU6
names: Similarity
messages: Belongs to the CDI family.

9615:NR1D1
gene id: 9615:NR1D1
uniprot id: A0A8C0PLP6
uniprot id: A0A8I3RVG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:AGXT2
gene id: 9615:AGXT2
uniprot id: A0A8C0S7U7
uniprot id: A0A8I3MGB1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9615:TEX13D
gene id: 9615:TEX13D
uniprot id: A0A8C0T025
uniprot id: A0A8I3PSM1
names: Similarity
messages: Belongs to the TEX13 family.

9615:SEPTIN2
gene id: 9615:SEPTIN2
uniprot id: A0A8C0RTU1
uniprot id: A0A8I3S4Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

9615:CPNE7
gene id: 9615:CPNE7
uniprot id: A0A8I3MMK8
uniprot id: A0A8P0NKV7
uniprot id: A0A8P0NL12
uniprot id: F1P6M8
names: Similarity
messages: Belongs to the copine family.

9615:NPM3
gene id: 9615:NPM3
uniprot id: A0A8C0NNB1
names: Similarity
messages: Belongs to the nucleoplasmin family.

9615:OPRM1
gene id: 9615:OPRM1
uniprot id: A0A0F6TMT6
uniprot id: A0A8C0T198
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

9615:LAMTOR1
gene id: 9615:LAMTOR1
uniprot id: A0A8C0TAQ5
uniprot id: A0A8I3NFM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9615:OR11G9
gene id: 9615:OR11G9
uniprot id: A0A8C0QGC7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:POPDC3
gene id: 9615:POPDC3
uniprot id: A0A8C0QPE1
uniprot id: A0A8I3N6B6
names: Similarity
messages: Belongs to the popeye family.

9615:TM6SF1
gene id: 9615:TM6SF1
uniprot id: A0A8C0NAD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

9615:SNAP91
gene id: 9615:SNAP91
uniprot id: A0A8C0QPT1
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9615:ADH5
gene id: 9615:ADH5
uniprot id: A0A8C0P4Y3
uniprot id: A0A8I3PVI9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

9615:RRAGA
gene id: 9615:RRAGA
uniprot id: A0A8C0T7N8
uniprot id: A0A8I3NIS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9615:MRPS33
gene id: 9615:MRPS33
uniprot id: A0A8C0MR07
uniprot id: A0A8I3QDM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9615:COPS7B
gene id: 9615:COPS7B
uniprot id: A0A8C0TN28
uniprot id: A0A8I3PIA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9615:RAB8A
gene id: 9615:RAB8A
uniprot id: P61007
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus
messages: Interacts (GTP-bound form) with MICALL1; regulates RAB8A association with recycling endosomes (By similarity). Interacts with MICALL2; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity). Interacts (GTP-bound form) with MICAL1, MICALCL, MICAL3 and EHBP1L1; two molecules of RAB8A can bind to one molecule of the effector protein; ternary complexes of RAB8A, RAB13 and either MICAL1 or EHBP1L1 are possible (By similarity). Interacts (GTP-bound form) with EHBP1 (By similarity). Interacts with EHD1 (By similarity). Interacts with MAP4K2 and SYTL4 (By similarity). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with RABIF, RIMS2, RPH3A and RPH3A (By similarity). Interacts with OPTN (By similarity). Interacts with RAB3IP (By similarity). Interacts with MYO5B (By similarity). Interacts with CIMAP3 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with OCRL (By similarity). Interacts with AHI1 (By similarity). Interacts with DCDC1 (By similarity). Interacts with LRRK2; interaction facilitates phosphorylation of Thr-72 (By similarity). Interacts with RAB31P, GDI1, GDI2, CHM, CHML, RABGGTA, RABGGTB, TBC1D15 and INPP5B; these interactions are dependent on Thr-72 not being phosphorylated (By similarity). Interacts with RILPL1 and RILPL2; these interactions are dependent on the phosphorylation of Thr-72 by LRRK2 (By similarity). Interacts with DZIP1; prevents inhibition by the GDP-dissociation inhibitor GDI2 (By similarity).
messages: Midbody
messages: Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Recycling endosome membrane
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase (By similarity). Activated in response to insulin (By similarity).
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Regulates the compacted morphology of the Golgi (By similarity). Together with MYO5B and RAB11A participates in epithelial cell polarization. Also involved in membrane trafficking to the cilium and ciliogenesis (By similarity). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (By similarity).
messages: centriole
messages: cilium
messages: cilium basal body
messages: phagosome membrane

9615:HARBI1
gene id: 9615:HARBI1
uniprot id: A0A8C0SH41
uniprot id: A0A8I3PY52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9615:TP53I11
gene id: 9615:TP53I11
uniprot id: A0A8C0PCS4
uniprot id: A0A8I3N2A4
names: Subcellular Location Annotation
messages: Membrane

9615:FOSB
gene id: 9615:FOSB
uniprot id: Q9TUB3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Fos subfamily.
messages: Binds DNA via bZIP domain; DNA-binding is under control of cellular redox homeostasis (in vitro) (By similarity). To enable DNA binding, the bZIP domain must undergo a conformational rearrangement which requires the reduction of the interchain disulfide bond between FosB and JunD (in vitro) (By similarity). The bZIP domain is able to form homomeric oligomers via formation of interchain disulfide bonds under non-reducing conditions (in vitro) (By similarity). Under reducing conditions, the disulfide-bonded homomeric species dissociates into monomers (in vitro) (By similarity).
messages: Heterodimer; binds to DNA as heterodimer (By similarity). Component of an AP-1 transcription factor complex; composed of FOS-JUN heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with JUN, JUNB or JUND, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Interacts with the BAF multiprotein chromatin-remodeling complex subunits SMARCB1 and SMARCD1 (By similarity). Interacts with ARID1A and JUN (By similarity).
messages: Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity (By similarity). Exhibits transactivation activity in vitro (By similarity). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity).
messages: Nucleus
messages: Phosphorylated.

9615:ELOVL6
gene id: 9615:ELOVL6
uniprot id: A0A8C0Z609
uniprot id: A0A8I3QXG1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

9615:AQP10
gene id: 9615:AQP10
uniprot id: A0A8C0RW51
uniprot id: A0A8I3S111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9615:CXCR5
gene id: 9615:CXCR5
uniprot id: A0A8C0MC57
uniprot id: A0A8I3MGQ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:TRPM6
gene id: 9615:TRPM6
uniprot id: A0A8I3NMH9
uniprot id: A0A8P0NQW0
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

9615:MCHR2
gene id: 9615:MCHR2
uniprot id: Q8MIP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:KAT2A
gene id: 9615:KAT2A
uniprot id: A0A8C0M065
uniprot id: A0A8I3NA81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: centrosome

9615:BCL2L13
gene id: 9615:BCL2L13
uniprot id: A0A8C0PIS3
uniprot id: A0A8I3Q526
names: Similarity
messages: Belongs to the Bcl-2 family.

9615:PFN3
gene id: 9615:PFN3
uniprot id: A0A8C0SP78
uniprot id: A0A8I3N5I2
names: Similarity
messages: Belongs to the profilin family.

9615:C9H9orf78
gene id: 9615:C9H9orf78
uniprot id: A0A8I3PEF5
uniprot id: A0A8P0NL33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLS1 family.
messages: Nucleus

9615:EEF1G
gene id: 9615:EEF1G
uniprot id: A0A8C0TD64
uniprot id: A0A8I3NDU5
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9615:IDE
gene id: 9615:IDE
uniprot id: U5XYR4
names: Similarity
messages: Belongs to the peptidase M16 family.

9615:NINJ1
gene id: 9615:NINJ1
uniprot id: A0A8C0RAF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

9615:TPO
gene id: 9615:TPO
uniprot id: Q8HYB7
names: Cofactor
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxidase family. XPO subfamily.
messages: Binds 1 Ca(2+) ion per heterodimer.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.
messages: Cleaved in its N-terminal part.
messages: Defects in TPO are the cause of congenital hypothyroidism with goiter, a simple autosomal recessive trait observed in Toy Fox Terriers (TFTs). Neonatal affected pups exhibited inactivity, abnormal hair coat, stenotic ear canals, and delayed eye opening. Palpable ventrolateral cervical swellings were evident by 1 week of age. Serum thyroid hormone and thyroid-stimulating hormone concentrations were low and high, respectively. Histologic examination of the cervical masses disclosed cuboidal to columnar follicular epithelial cell hyperplasia with widely varying follicular size, shape, and amount of colloid. Oral thyroid hormone replacement therapy restored near-normal growth and development. At 8 weeks of age, radioiodine uptake and perchlorate discharge testing indicated an iodine organification defect. Biochemical analysis of thyroid tissue from affected dogs demonstrated enzymatic iodine oxidation deficiency and lack of sodium dodecyl sulfate-resistant thyroglobulin dimers, suggesting thyroid peroxidase deficiency.
messages: Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface (By similarity).
messages: Interacts with DUOX1, DUOX2 and CYBA.
messages: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
messages: Membrane

9615:ADIPOR1
gene id: 9615:ADIPOR1
uniprot id: A0A8C0RBA1
uniprot id: A0A8I3NRK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9615:EYA1
gene id: 9615:EYA1
uniprot id: A0A8C0RFH1
uniprot id: A0A8C0TL92
uniprot id: A0A8C0TNQ1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9615:OXA1L
gene id: 9615:OXA1L
uniprot id: A0A8I3MJX8
uniprot id: A0A8P0NCZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9615:NIPBL
gene id: 9615:NIPBL
uniprot id: A0A8C0RAG9
uniprot id: A0A8I3RRT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9615:KRT15
gene id: 9615:KRT15
uniprot id: A0A8C0S9K8
names: Similarity
messages: Belongs to the intermediate filament family.

9615:APPL1
gene id: 9615:APPL1
uniprot id: A0A8P0NAH5
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9615:HOXA4
gene id: 9615:HOXA4
uniprot id: A0A8C0S465
uniprot id: A0A8I3N8X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:FLVCR2
gene id: 9615:FLVCR2
uniprot id: A0A8C0NVB0
uniprot id: A0A8I3P1S2
names: Subcellular Location Annotation
messages: Membrane

9615:NFE2
gene id: 9615:NFE2
uniprot id: A0A8P0NPP8
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9615:VPS36
gene id: 9615:VPS36
uniprot id: A0A8C0NVX9
uniprot id: A0A8C0RNS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

9615:PLD3
gene id: 9615:PLD3
uniprot id: A0A8C0SB92
uniprot id: A0A8I3MMY6
names: Similarity
messages: Belongs to the phospholipase D family.

9615:NCR1
gene id: 9615:NCR1
uniprot id: A0A8C0S685
uniprot id: E2QUF9
names: Subcellular Location Annotation
messages: Cell membrane

9615:SPTBN1
gene id: 9615:SPTBN1
uniprot id: A0A8C0RTN3
uniprot id: A0A8I3NBT5
names: Similarity
messages: Belongs to the spectrin family.

9615:ABR
gene id: 9615:ABR
uniprot id: A0A8C0MFW9
uniprot id: A0A8C0RDL6
uniprot id: A0A8I3NPR1
uniprot id: A0A8I3NPZ9
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9615:PELI3
gene id: 9615:PELI3
uniprot id: A0A8C0SF51
uniprot id: A0A8I3NZQ5
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9615:HSD17B3
gene id: 9615:HSD17B3
uniprot id: A0A8C0MSR5
uniprot id: A0A8C0Q1B2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:HR
gene id: 9615:HR
uniprot id: A0A8I3QB60
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9615:AGMAT
gene id: 9615:AGMAT
uniprot id: A0A8C0QB28
uniprot id: A0A8I3RP09
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

9615:CCR4
gene id: 9615:CCR4
uniprot id: Q8MJW8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in thymus, spleen, heart, small intestine and lymph node.
messages: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival (By similarity).
messages: In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.

9615:NRP1
gene id: 9615:NRP1
uniprot id: A0A8C0PU36
uniprot id: A0A8I3N3A8
uniprot id: A0A8I3N3D9
uniprot id: A0A8P0T2A8
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:HNRNPR
gene id: 9615:HNRNPR
uniprot id: A0A8C0M170
uniprot id: A0A8C0Q3X1
uniprot id: A0A8I3NWS4
names: Subcellular Location Annotation
messages: Cytoplasm

9615:TNR
gene id: 9615:TNR
uniprot id: A0A8I3RVA0
uniprot id: A0A8P0NNA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9615:E2F8
gene id: 9615:E2F8
uniprot id: A0A8C0PIG7
uniprot id: A0A8I3P386
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9615:ATP8B1
gene id: 9615:ATP8B1
uniprot id: A0A8C0MJZ1
uniprot id: A0A8C0RZS9
uniprot id: A0A8I3MQM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:COX8A
gene id: 9615:COX8A
uniprot id: A0A8C0SNZ0
uniprot id: A0A8I3QBW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9615:TRH
gene id: 9615:TRH
uniprot id: A0A8C0NVG0
uniprot id: A0A8I3Q081
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

9615:ITGAX
gene id: 9615:ITGAX
uniprot id: A0A8C0M955
uniprot id: A0A8I3NEY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:ACR
gene id: 9615:ACR
uniprot id: A0A8C0RLN6
uniprot id: A0A8I3PYH1
names: Function
names: Similarity
names: Subunit
messages: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
messages: Belongs to the peptidase S1 family.
messages: Heavy chain (catalytic) and a light chain linked by two disulfide bonds. Forms a heterodimer with SERPINA5.

9615:PIGO
gene id: 9615:PIGO
uniprot id: A0A8C0RKX1
uniprot id: A0A8I3MQG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:SEC24B
gene id: 9615:SEC24B
uniprot id: A0A8C0PFF1
uniprot id: A0A8C0RS65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9615:CASP12
gene id: 9615:CASP12
uniprot id: Q075B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by two subunits (Potential). May interact with TRAF2 (By similarity).
messages: Involved in the activation cascade of caspases responsible for apoptosis execution.

9615:SCNN1B
gene id: 9615:SCNN1B
uniprot id: Q95165
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by WNK1, WNK2, WNK3 and WNK4.
messages: Apical cell membrane
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.
messages: Cytoplasmic vesicle membrane
messages: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties. Interacts with NEDD4 (via WW domains). Interacts with NEDD4L (via WW domains). Interacts with WWP1 (via WW domains). Interacts with WWP2 (via WW domains). Interacts with the full-length immature form of PCSK9 (pro-PCSK9). Interacts (N-glycosylated) with BPIFA1; the interaction is direct and inhibits the proteolytic processing of SCNN1A and SCNN1G and the activation of ENaC.
messages: N-glycosylated. N-glycosylation is required for interaction with BPIFA1.
messages: Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

9615:CAP1
gene id: 9615:CAP1
uniprot id: A0A8C0YXX5
uniprot id: A0A8I3NG14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9615:QKI
gene id: 9615:QKI
uniprot id: Q9GMY1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the quaking family.
messages: Cytoplasm
messages: Homodimer; does not require RNA to homodimerize (By similarity). Able to heterodimerize with BICC1 (By similarity).
messages: Methylated by PRMT1.
messages: Nucleus
messages: RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularization of pre-mRNAs. Plays a central role in myelinization via 3 distinct mechanisms (By similarity). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation. Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA. Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation. Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (By similarity). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts. Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1.…
messages: The KH domain and the Qua2 region are involved in RNA binding.
messages: Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).
messages: Ubiquitinated by RNF6 in macrophages, leading to its degradation.

9615:PSME3
gene id: 9615:PSME3
uniprot id: A0A8C0M1E1
uniprot id: A0A8C0TAV1
uniprot id: A0A8I3MUQ5
uniprot id: A0A8I3MWG3
names: Similarity
messages: Belongs to the PA28 family.

9615:ITGB6
gene id: 9615:ITGB6
uniprot id: A0A8C0N458
uniprot id: A0A8C0TDZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

9615:TP63
gene id: 9615:TP63
uniprot id: A0A8C0P4Y6
uniprot id: A0A8C0RNE9
uniprot id: A0A8I3PKL5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

9615:SLC2A4
gene id: 9615:SLC2A4
uniprot id: A0A8C0Q762
uniprot id: A0A8I3PA13
uniprot id: Q9XST2
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Binds to DAXX. Interacts via its N-terminus with SRFBP1 (By similarity). Interacts with NDUFA9 (By similarity). Interacts with TRARG1; the interaction is required for proper SLC2A4 recycling after insulin stimulation (By similarity).
messages: Cell membrane
messages: Endomembrane system
messages: Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
messages: Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.
messages: Membrane
messages: Palmitoylated. Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane.
messages: Sumoylated.
messages: The dileucine internalization motif is critical for intracellular sequestration.
messages: perinuclear region

9615:PODXL
gene id: 9615:PODXL
uniprot id: Q52S86
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the podocalyxin family.
messages: Expressed in glomerular and tubular epithelial cells and peritubular capillaries of the kidney (at protein level). Expressed in heart, lung, renal cortex and medulla, kidney and muscle.
messages: Found in a complex with EZR, PODXL and NHERF2. Associates with the actin cytoskeleton through complex formation with EZR and NHERF2. Interacts (via the C-terminal PDZ-binding motif DTHL) with NHERF1 (via the PDZ domains); interaction is not detected in glomerular epithelium cells. Interacts (via the C-terminal PDZ-binding motif DTHL) with NHERF2 (via the PDZ 1 domain); interaction is detected in glomerular epithelium cells. Interacts with EZR (By similarity). Monomer; when associated with the membrane raft. Oligomer; when integrated in the apical membrane. Interacts with NHERF2. Interacts (via the C-terminal PDZ-binding motif DTHL) with NHERF1 (via the PDZ domains); the interaction take place early in the secretory pathway and is necessary for its apical membrane sorting.
messages: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
messages: Membrane
messages: Membrane raft
messages: N- and O-linked glycosylated. Sialoglycoprotein.
messages: The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with NHERF1 and for targeting NHERF1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity). Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis.
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

9615:BTBD10
gene id: 9615:BTBD10
uniprot id: A0A8C0RU05
uniprot id: A0A8I3S1W5
names: Subcellular Location Annotation
messages: Cytoplasm

9615:ACRBP
gene id: 9615:ACRBP
uniprot id: A0A8C0T3N2
names: Subcellular Location Annotation
messages: acrosome

9615:SAMHD1
gene id: 9615:SAMHD1
uniprot id: A0A8C0SIE9
uniprot id: A0A8I3PZF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

9615:CLPP
gene id: 9615:CLPP
uniprot id: A0A8C0NYE4
uniprot id: A0A8I3N7L4
names: Similarity
messages: Belongs to the peptidase S14 family.

9615:SEC61B
gene id: 9615:SEC61B
uniprot id: P60467
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:8107851). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:8107851). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:36261528). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity).
messages: Endoplasmic reticulum membrane
messages: The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:10799540, PubMed:10860986, PubMed:8107851, PubMed:36261528). The SEC61 channel associates with the multi-pass translocon (MPT) complex (PubMed:36261528). Interacts with TRAM1 (By similarity).

9615:TMEM86A
gene id: 9615:TMEM86A
uniprot id: A0A8C0P2V9
uniprot id: A0A8I3P610
uniprot id: A0A8P0SU62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9615:TM4SF18
gene id: 9615:TM4SF18
uniprot id: A0A8C0MTH8
uniprot id: A0A8I3PZA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9615:SMOC1
gene id: 9615:SMOC1
uniprot id: A0A8C0PY58
uniprot id: A0A8I3MT33
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CPLX4
gene id: 9615:CPLX4
uniprot id: A0A8C0Q1X4
uniprot id: A0A8I3MKV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9615:TNC
gene id: 9615:TNC
uniprot id: A0A8I3NF05
uniprot id: A0A8P0N6C4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:SLC35A2
gene id: 9615:SLC35A2
uniprot id: Q8WMS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Interacts with SLC35A3; the interaction is reduced in the presence of SLC35A4 (By similarity). Found in a complex with SLC35A3 and SLC35A4 (By similarity).
messages: Transports uridine diphosphate galactose (UDP-galactose) from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges UDP-galactose for UMP. It is also able to exchange UDP-galactose for AMP and CMP, and to transport UDP-N-acetylgalactosamine (UDP-GalNAc) and other nucleotide sugars. As a provider of UDP-galactose to galactosyltransferases present in the Golgi apparatus, it is necessary for globotriaosylceramide/globoside (Gb3Cer) synthesis from lactosylceramide.

9615:PIK3IP1
gene id: 9615:PIK3IP1
uniprot id: A0A8I3PG51
uniprot id: A0A8P0PFV2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TMED11
gene id: 9615:TMED11
uniprot id: P27869
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Part of a complex whose function is to bind Ca(2+) to the ER membrane and thereby regulate the retention of ER resident proteins.

9615:MAP2K6
gene id: 9615:MAP2K6
uniprot id: A0A8C0M2T9
uniprot id: A0A8I3NBF5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:TASP1
gene id: 9615:TASP1
uniprot id: A0A8I3PTN4
uniprot id: A0A8I3S6D3
uniprot id: A0A8P0TKE4
uniprot id: A0A8P0TS57
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9615:CCND1
gene id: 9615:CCND1
uniprot id: Q64HP0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity (By similarity). Interacts directly with CDKN1B. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with FBXO4 (By similarity). Interacts with UHRF2; the interaction ubiquitinates CCND1 and appears to occur independently of phosphorylation. Interacts with USP2. Interacts (via cyclin N-terminal domain) with INSM1 (via N-terminal region); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and inhibits CDK4 activity. Interacts with CDK4; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression (By similarity).
messages: Nucleus
messages: Nucleus membrane
messages: Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex. It also plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex following DNA damage.
messages: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
messages: Ubiquitinated at Lys-270 by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-286 phosphorylation. The DCX(AMBRA1) complex represents the major regulator of CCND1 stability during the G1/S transition (By similarity). Also ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB (By similarity). Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. SCF-type ubiquitination is dependent on Thr-286 phosphorylation. Ubiquitinated also by UHRF2 apparently in a phosphorylation-independent manner. Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to its stabilization (By similarity).

9615:ASPM
gene id: 9615:ASPM
uniprot id: P62286
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).
messages: spindle

9615:SIAH1
gene id: 9615:SIAH1
uniprot id: A0A8C0SRQ4
uniprot id: A0A8C0YZ25
uniprot id: A0A8I3MT88
uniprot id: A0A8I3MTY8
uniprot id: A0A8I3RS36
uniprot id: A0A8P0PKA4
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9615:RMI1
gene id: 9615:RMI1
uniprot id: A0A8C0MBY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9615:CLDN1
gene id: 9615:CLDN1
uniprot id: A0A8C0T9W5
uniprot id: A0A8I3PHM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:HSPA14
gene id: 9615:HSPA14
uniprot id: A0A8C0Q3K4
uniprot id: A0A8I3RYL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9615:MLLT11
gene id: 9615:MLLT11
uniprot id: A0A8C0MMI6
uniprot id: A0A8I3PMH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9615:PER3
gene id: 9615:PER3
uniprot id: A0A8P0PNZ3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:PLA2G2F
gene id: 9615:PLA2G2F
uniprot id: A0A8C0QIT8
uniprot id: A0A8I3MGW4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9615:DOHH
gene id: 9615:DOHH
uniprot id: A0A8C0RE17
uniprot id: A0A8I3NC31
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

9615:HSD17B6
gene id: 9615:HSD17B6
uniprot id: A0A8C0ND12
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:CSNK1G3
gene id: 9615:CSNK1G3
uniprot id: A0A8C0PIH9
uniprot id: A0A8C0Q7S6
uniprot id: A0A8I3N7M4
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9615:RALY
gene id: 9615:RALY
uniprot id: M9PM25
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9615:TMEM205
gene id: 9615:TMEM205
uniprot id: A0A8C0P6U5
uniprot id: A0A8I3S124
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9615:ELAVL3
gene id: 9615:ELAVL3
uniprot id: A0A8C0P6K1
uniprot id: A0A8I3S0J9
names: Similarity
messages: Belongs to the RRM elav family.

9615:ZFP36L2
gene id: 9615:ZFP36L2
uniprot id: A0A8P0SS70
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9615:HASPIN
gene id: 9615:HASPIN
uniprot id: A0A8P0SND6
names: Subcellular Location Annotation
messages: Chromosome

9615:LZTS2
gene id: 9615:LZTS2
uniprot id: A0A8C0TDW0
uniprot id: A0A8I3NZ94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

9615:SRP9
gene id: 9615:SRP9
uniprot id: A0A8C0SEN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9615:TUBB6
gene id: 9615:TUBB6
uniprot id: A0A8C0M5E1
uniprot id: A0A8I3MYG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:ADAM17
gene id: 9615:ADAM17
uniprot id: A0A8C0Q8D6
uniprot id: A0A8I3PUH7
uniprot id: A0A8I3Q5Z6
uniprot id: A0A8P0PDW3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:LOC106558389
gene id: 9615:LOC106558389
uniprot id: A0A8C0P517
uniprot id: A0A8I3PKC2
names: Similarity
messages: Belongs to the profilin family.

9615:CMTM8
gene id: 9615:CMTM8
uniprot id: A0A8C0Z0K7
uniprot id: A0A8I3PH34
names: Subcellular Location Annotation
messages: Membrane

9615:IL25
gene id: 9615:IL25
uniprot id: A0A8I3MRV2
uniprot id: A0A8P0NDF4
names: Similarity
messages: Belongs to the IL-17 family.

9615:KCNV1
gene id: 9615:KCNV1
uniprot id: A0A8C0SFJ0
uniprot id: A0A8I3NTA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9615:MED24
gene id: 9615:MED24
uniprot id: A0A8C0Q2Z1
uniprot id: A0A8I3N3B0
uniprot id: A0A8I3NF58
uniprot id: A0A8P0T2C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9615:SRD5A2
gene id: 9615:SRD5A2
uniprot id: A0A8C0NNA6
uniprot id: A0A8I3NQ64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9615:KCNK10
gene id: 9615:KCNK10
uniprot id: A0A8C0M8T0
uniprot id: A0A8I3N317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9615:FXYD1
gene id: 9615:FXYD1
uniprot id: A0A8C0Q6J0
uniprot id: A0A8I3MRH3
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the FXYD family.
messages: Cell membrane
messages: Membrane
messages: T-tubule
messages: caveola
messages: sarcolemma

9615:PPIC
gene id: 9615:PPIC
uniprot id: A0A8P0NP26
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9615:SLC9A3R1
gene id: 9615:SLC9A3R1
uniprot id: E2RGF3
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

9615:SLC24A4
gene id: 9615:SLC24A4
uniprot id: A0A8C0LT58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9615:GALNT10
gene id: 9615:GALNT10
uniprot id: A0A8C0QF66
uniprot id: A0A8I3MW00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:FGD2
gene id: 9615:FGD2
uniprot id: A0A8C0MT27
uniprot id: A0A8I3N5A7
names: Subcellular Location Annotation
messages: cytoskeleton

9615:HPD
gene id: 9615:HPD
uniprot id: A0A8C0Z0E2
uniprot id: A0A8I3PEX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9615:RHBG
gene id: 9615:RHBG
uniprot id: Q4VUI0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport (By similarity). May act as a CO2 channel providing for renal acid secretion (By similarity).
messages: Basolateral cell membrane
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cell membrane
messages: Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane.
messages: N-glycosylated.

9615:CDH2
gene id: 9615:CDH2
uniprot id: A0A8C0SNQ2
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9615:WSCD2
gene id: 9615:WSCD2
uniprot id: A0A8C0RU85
uniprot id: A0A8I3PVY6
names: Function
names: Similarity
messages: Belongs to the WSCD family.
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

9615:CCND2
gene id: 9615:CCND2
uniprot id: A0A8I3SCS2
uniprot id: A0A8P0T2S1
names: Similarity
messages: Belongs to the cyclin family.

9615:LOC102154136
gene id: 9615:LOC102154136
uniprot id: A0A8I3PQ15
uniprot id: A0A8P0TTD1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9615:PIK3C3
gene id: 9615:PIK3C3
uniprot id: A0A8C0QN39
uniprot id: A0A8I3MWD3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9615:HSPB3
gene id: 9615:HSPB3
uniprot id: A0A8C0QCY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Nucleus

9615:TECR
gene id: 9615:TECR
uniprot id: A0A8P0SZF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:SLC5A2
gene id: 9615:SLC5A2
uniprot id: A0A8C0YT22
uniprot id: A0A8I3NI32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9615:TINAG
gene id: 9615:TINAG
uniprot id: A0A8C0NDM9
names: Similarity
messages: Belongs to the peptidase C1 family.

9615:TMOD3
gene id: 9615:TMOD3
uniprot id: A0A8I3S5X2
uniprot id: A0A8P0NH04
names: Subcellular Location Annotation
messages: cytoskeleton

9615:VBP1
gene id: 9615:VBP1
uniprot id: A0A8C0TD93
uniprot id: A0A8I3P4S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9615:OSBP2
gene id: 9615:OSBP2
uniprot id: A0A8C0THL7
names: Similarity
messages: Belongs to the OSBP family.

9615:BLM
gene id: 9615:BLM
uniprot id: A0A8C0RAG2
uniprot id: A0A8I3MFB9
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9615:LOC491264
gene id: 9615:LOC491264
uniprot id: A0A8P0SNI2
names: Similarity
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Monomer.

9615:SLC12A9
gene id: 9615:SLC12A9
uniprot id: A0A8C0RRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9615:LLPH
gene id: 9615:LLPH
uniprot id: A0A8C0N155
uniprot id: A0A8I3NNR1
names: Similarity
messages: Belongs to the learning-associated protein family.

9615:CAMK2A
gene id: 9615:CAMK2A
uniprot id: A0A8C0S5Z7
uniprot id: A0A8I3MXQ9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9615:RAG1
gene id: 9615:RAG1
uniprot id: A0A8C0SIL6
uniprot id: A0A8I3PC48
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAG1 family.
messages: Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.
messages: Homodimer.
messages: Nucleus
messages: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.

9615:MLEC
gene id: 9615:MLEC
uniprot id: A0A8C0TEU8
uniprot id: A0A8I3Q5B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:SENP6
gene id: 9615:SENP6
uniprot id: A0A8C0MMG0
uniprot id: A0A8C0TBK0
uniprot id: A0A8C0TEP7
uniprot id: A0A8C0TFJ1
names: Similarity
messages: Belongs to the peptidase C48 family.

9615:TAGLN3
gene id: 9615:TAGLN3
uniprot id: A0A8C0TIB2
uniprot id: A0A8I3PZB6
names: Similarity
messages: Belongs to the calponin family.

9615:RGR
gene id: 9615:RGR
uniprot id: A0A8C0M006
names: Subcellular Location Annotation
messages: Membrane

9615:RPS24
gene id: 9615:RPS24
uniprot id: A0A8C0TRJ0
uniprot id: A0A8C0TTU5
uniprot id: A0A8C0TVV8
uniprot id: A0A8C0TW16
uniprot id: A0A8C0Z6H5
uniprot id: A0A8I3NSJ8
uniprot id: A0A8I3S0M2
uniprot id: H9GWG6
uniprot id: J9NRJ3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

9615:DHRS11
gene id: 9615:DHRS11
uniprot id: A0A8C0PLJ9
uniprot id: A0A8I3Q1V9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:ATP6V1G3
gene id: 9615:ATP6V1G3
uniprot id: A0A8C0PCR3
uniprot id: A0A8I3PWA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9615:RAD21
gene id: 9615:RAD21
uniprot id: A0A8C0MCU4
uniprot id: A0A8I3P294
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9615:PIM2
gene id: 9615:PIM2
uniprot id: A0A8C0S661
uniprot id: A0A8I3SCW6
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9615:PLEKHA8
gene id: 9615:PLEKHA8
uniprot id: D2KC46
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
messages: Homodimer. Interacts with ARF1; the interaction together with phosphatidylinositol 4-phosphate binding is required for FAPP2 GlcCer transfer ability (By similarity).
messages: Membrane
messages: The PH domain of FAPPS binds the small GTPase ARF1 and phosphatidylinositol-4-phosphate (PtdIns4P) with high selectivity, and is required for recruitment of FAPPs to the trans-Golgi network (TGN).
messages: trans-Golgi network membrane

9615:CHAF1B
gene id: 9615:CHAF1B
uniprot id: A0A8P0NBR1
names: Subcellular Location Annotation
messages: Nucleus

9615:KLRK1
gene id: 9615:KLRK1
uniprot id: A0A8C0NXD8
uniprot id: A0A8I3PNL2
names: Subcellular Location Annotation
messages: Cell membrane

9615:FITM2
gene id: 9615:FITM2
uniprot id: A0A8C0TPZ8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:ID3
gene id: 9615:ID3
uniprot id: Q712G9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer, and heterodimer with other HLH proteins. Interacts with COPS5 and COPS7A. Interacts with IFI204. Interacts with GATA4 and NKX2-5. Interacts with ANKRD2; both proteins cooperate in myoblast differentiation. Interacts with CLOCK and BMAL1 (By similarity).
messages: Nucleus
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity).

9615:KRT81
gene id: 9615:KRT81
uniprot id: A0A8C0P8D1
uniprot id: A0A8I3PTF9
names: Similarity
messages: Belongs to the intermediate filament family.

9615:PATL1
gene id: 9615:PATL1
uniprot id: A0A8I3S2D6
uniprot id: A0A8P0SCX3
names: Similarity
messages: Belongs to the PAT1 family.

9615:TSPAN7
gene id: 9615:TSPAN7
uniprot id: A0A8C0MWY4
uniprot id: A0A8I3S5K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:ARMC1
gene id: 9615:ARMC1
uniprot id: A0A8C0T7P4
uniprot id: A0A8I3S2W4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

9615:CPT2
gene id: 9615:CPT2
uniprot id: A0A8C0RCF5
uniprot id: A0A8I3NSG5
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9615:SH3GL1
gene id: 9615:SH3GL1
uniprot id: A0A8C0PDF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9615:PGM3
gene id: 9615:PGM3
uniprot id: A0A8I3NIM7
uniprot id: A0A8P0NVH8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

9615:NCF2
gene id: 9615:NCF2
uniprot id: A7E3N1
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9615:CTNNB1
gene id: 9615:CTNNB1
uniprot id: B6V8E6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-catenin family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Deacetylated at Lys-49 by SIRT1.
messages: Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity).
messages: Nucleus
messages: O-glycosylation at Ser-23 decreases nuclear localization and transcriptional activity, and increases localization to the plasma membrane and interaction with E-cadherin CDH1.
messages: Phosphorylation by GSK3B requires prior phosphorylation of Ser-45 by another kinase. Phosphorylation proceeds then from Thr-41 to Ser-33. Phosphorylated by NEK2. EGF stimulates tyrosine phosphorylation. Phosphorylated on Ser-33 and Ser-37 by HIPK2. This phosphorylation triggers proteasomal degradation. Phosphorylation at Ser-552 by AMPK promotes stabilization of the protein, enhancing TCF/LEF-mediated transcription. Phosphorylation on Ser-191 and Ser-246 by CDK5. Phosphorylation by CDK2 regulates insulin internalization. Phosphorylation by PTK6 at Tyr-64, Tyr-142, Tyr-331 and/or Tyr-333 with the predominant site at Tyr-64 is not essential for inhibition of transcriptional activity. Phosphorylation by SRC at Tyr-333 promotes interaction with isoform M2 of PKM (PKM2); promoting transcription activation.
messages: S-nitrosylation at Cys-619 within adherens junctions promotes VEGF-induced, NO-dependent endothelial cell permeability by disrupting interaction with E-cadherin, thus mediating disassembly adherens junctions.
messages: Synapse
messages: Two separate complex-associated pools are found in the cytoplasm. The majority is present as part of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and beta-catenin/CTNNB1, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Binds NHERF1. Interacts with PTPRU (via the cytoplasmic juxtamembrane domain) and with EMD. Interacts with SESTD1 and TRPC4. Interacts with CAV1. Interacts with PTPRJ. Interacts with PKT7. Interacts with FAT1 (via the cytoplasmic domain). Interacts with CDK2, NDRG2 and NANOS1. Interacts with NEK2 and CDK5. Interacts with CARM1, CXADR, PCDH11Y and PTK6. Interacts with SOX7; this interaction may lead to proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. Identified in a complex with HINT1 and MITF. Interacts with FHIT. Interacts with FERMT2. Identified in a complex with TCF4 and FERMT2. Another cytoplasmic pool is part of a large complex containing AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. Wnt-dependent activation of DVL antagonizes the action of GSK3B. When GSK3B activity is inhibited, the complex disassociates, CTNNB1 is dephosphorylated and is no longer targeted for destruction. The stabilized protein translocates to the nucleus, where it binds TCF/LEF-1 family members, BCL9, BCL9L and possibly also RUVBL1 and CHD8. Interacts with TAX1BP3 (via the PDZ domain); this interaction inhibits the transcriptional activity of CTNNB1. Interacts with AJAP1, BAIAP1 and CTNNA3. Interacts with TRPV4; the TRPV4 and CTNNB1 complex can interact with CDH1. Interacts with VCL. The CT…
messages: Ubiquitinated by the SCF(BTRC) E3 ligase complex when phosphorylated by GSK3B, leading to its degradation. Ubiquitinated by a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X, leading to its subsequent proteasomal degradation (By similarity). Ubiquitinated and degraded following interaction with SOX9 (By similarity).
messages: adherens junction
messages: centrosome
messages: cilium basal body
messages: cytoskeleton
messages: spindle pole

9615:ICMT
gene id: 9615:ICMT
uniprot id: A0A8C0RE09
uniprot id: A0A8I3PFI6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:MRPL14
gene id: 9615:MRPL14
uniprot id: A0A8C0S4D6
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9615:NLK
gene id: 9615:NLK
uniprot id: E2QWQ2
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by the non-canonical Wnt signaling pathway, in which WNT5A leads to activation of MAP3K7/TAK1 and HIPK2, which subsequently phosphorylates and activates this protein. Activated by dimerization and subsequent intermolecular autophosphorylation on Thr-298. Other cytokines such as IL6 may also activate this regulatory circuit (By similarity).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. This mode of activation contrasts with that of classical MAP kinases, which contain a TXY activation loop motif in which phosphorylation of both the threonine and tyrosine residues is required for kinase activation.
messages: Cytoplasm
messages: Homodimer. Homodimerization is required for intermolecular autophosphorylation, kinase activation and nuclear localization (By similarity). May interact with components of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes (By similarity). Interacts with LEF1, MEF2A, MYBL1 and MYBL2 (By similarity). Interacts with the upstream activating kinases HIPK2 and MAP3K7/TAK1. Interaction with MAP3K7/TAK1 seems to be indirect, and may be mediated by other proteins such as STAT3, TAB1 and TAB2. Interacts with and phosphorylates a number of transcription factors including FOXO1, FOXO3, FOXO4, MYB, NOTCH1 and TCF7L2/TCF4. Interacts with DAPK3/ZIPK, and this interaction may disrupt interaction with transcription factors such as TCF7L2/TCF4. Forms a transcriptional repressor complex with CHD7, PPARG and SETDB1. Interacts with RNF138/NARF (By similarity). Interacts with ATF5; the interaction stabilizes ATF5 at the protein level in a kinase-independent manner (By similarity).
messages: Nucleus
messages: Phosphorylated on Thr-298. Intermolecular autophosphorylation on Thr-298 activates the enzyme.
messages: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner. Acts as an inhibitor of the mTORC1 complex in response to osmotic stress by mediating phosphorylation of RPTOR, thereby preventing recruitment of the mTORC1 complex to lysosomes.

9615:ADGRD1
gene id: 9615:ADGRD1
uniprot id: A0A8I3Q1L5
uniprot id: A0A8I3QJJ9
uniprot id: A0A8P0N951
uniprot id: A0A8P0TFI4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:HNRNPD
gene id: 9615:HNRNPD
uniprot id: A0A8C0NEC1
uniprot id: A0A8C0NGU7
uniprot id: A0A8C0TJC8
uniprot id: A0A8I3P1C5
uniprot id: A0A8I3P1F3
uniprot id: A0A8I3P7D1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:RFTN1
gene id: 9615:RFTN1
uniprot id: A0A8C0TNM4
uniprot id: A0A8I3PS16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9615:LOC102156298
gene id: 9615:LOC102156298
uniprot id: A0A8P0TDR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:POLR2K
gene id: 9615:POLR2K
uniprot id: A0A8C0NDJ7
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9615:IFRD2
gene id: 9615:IFRD2
uniprot id: A0A8C0SRV3
uniprot id: A0A8I3PB80
names: Similarity
messages: Belongs to the IFRD family.

9615:LRRFIP2
gene id: 9615:LRRFIP2
uniprot id: A0A8C0MJE1
uniprot id: A0A8C0SLL8
uniprot id: A0A8C0SMG6
uniprot id: A0A8C0SMN3
uniprot id: A0A8I3PVI8
uniprot id: A0A8I3QEQ2
names: Similarity
messages: Belongs to the LRRFIP family.

9615:RPL27A
gene id: 9615:RPL27A
uniprot id: A0A8C0PGQ7
uniprot id: E2RI34
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9615:LOC608703
gene id: 9615:LOC608703
uniprot id: A0A8C0T7C9
uniprot id: E2QUE7
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9615:NUPR2
gene id: 9615:NUPR2
uniprot id: A0A8C0LXG5
uniprot id: A0A8I3RZX4
names: Similarity
messages: Belongs to the NUPR family.

9615:OXR1
gene id: 9615:OXR1
uniprot id: A0A8C0PBD0
uniprot id: A0A8C0PG51
uniprot id: A0A8C0PI46
uniprot id: A0A8C0QR11
uniprot id: A0A8C0QRD9
uniprot id: A0A8I3NSC6
uniprot id: A0A8I3RW23
uniprot id: A0A8P0SXQ5
names: Similarity
messages: Belongs to the OXR1 family.

9615:PRRX1
gene id: 9615:PRRX1
uniprot id: A0A8C0PWN6
uniprot id: A0A8C0R973
uniprot id: A0A8I3MZL1
uniprot id: A0A8I3RRN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9615:MRPL12
gene id: 9615:MRPL12
uniprot id: A0A8C0PKY3
uniprot id: A0A8I3NE78
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9615:COG4
gene id: 9615:COG4
uniprot id: A0A8C0REW2
uniprot id: A0A8I3MVA3
uniprot id: A0A8P0NL90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

9615:LOC479649
gene id: 9615:LOC479649
uniprot id: P04813
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: extracellular space

9615:PCK1
gene id: 9615:PCK1
uniprot id: A0A8C0PGX6
uniprot id: A0A8I3QWQ0
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9615:TAS2R40
gene id: 9615:TAS2R40
uniprot id: A0A8C0Q636
uniprot id: Q2ABD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:CDH5
gene id: 9615:CDH5
uniprot id: A0A8C0TC63
uniprot id: A0A8I3NHK1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9615:CDC37L1
gene id: 9615:CDC37L1
uniprot id: A0A8C0PZN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9615:EDC4
gene id: 9615:EDC4
uniprot id: A0A8C0YYG9
uniprot id: A0A8I3N2M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9615:CDC26
gene id: 9615:CDC26
uniprot id: A0A8C0P9T8
uniprot id: A0A8I3N4K8
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9615:LOC100855486
gene id: 9615:LOC100855486
uniprot id: A0A8C0PWK0
uniprot id: A0A8I3PRQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9615:PMS1
gene id: 9615:PMS1
uniprot id: A0A8C0NK78
uniprot id: A0A8C0NLA3
uniprot id: A0A8I3PNE6
uniprot id: A0A8I3S833
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9615:CMTM6
gene id: 9615:CMTM6
uniprot id: A0A8C0T010
uniprot id: F1PQS8
names: Subcellular Location Annotation
messages: Membrane

9615:IGBP1
gene id: 9615:IGBP1
uniprot id: A0A8C0TGP9
names: Similarity
messages: Belongs to the IGBP1/TAP42 family.

9615:FAM13A
gene id: 9615:FAM13A
uniprot id: A0A8C0PJ59
uniprot id: A0A8C0PSE4
uniprot id: A0A8C0RTK2
uniprot id: A0A8I3NW33
uniprot id: A0A8I3P8J6
names: Similarity
messages: Belongs to the FAM13 family.

9615:SH2B1
gene id: 9615:SH2B1
uniprot id: A0A8C0Q010
uniprot id: A0A8I3RR63
uniprot id: A0A8P0TBR9
names: Similarity
messages: Belongs to the SH2B adapter family.

9615:FUNDC1
gene id: 9615:FUNDC1
uniprot id: A0A8C0SMZ4
uniprot id: A0A8I3S6M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9615:DLX5
gene id: 9615:DLX5
uniprot id: A0A8C0SME5
uniprot id: A0A8I3PD70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9615:ERC1
gene id: 9615:ERC1
uniprot id: A0A8C0TU27
uniprot id: A0A8C0TVS2
uniprot id: A0A8C0Z783
uniprot id: A0A8I3PZD0
uniprot id: A0A8I3Q2L0
uniprot id: A0A8I3Q6V2
uniprot id: A0A8P0P0A3
names: Subcellular Location Annotation
messages: Cytoplasm

9615:EML3
gene id: 9615:EML3
uniprot id: A0A8C0T8M3
uniprot id: A0A8I3RWU2
names: Similarity
messages: Belongs to the WD repeat EMAP family.

9615:LIPF
gene id: 9615:LIPF
uniprot id: P80035
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:1568562, PubMed:1935982, PubMed:11689574). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (By similarity).
messages: Expressed in the mucous pit cells of gastric glands (at protein level) (PubMed:1568562). Expressed in the fundic and pyloric mucosa (PubMed:1935982).
messages: Inactivated by thiol reagents 5,5'- dithiobis(2-nitrobenzoic acid) and 4,4'-dithiopyridine.
messages: Secreted

9615:TRMO
gene id: 9615:TRMO
uniprot id: A0A8C0T0A4
uniprot id: A0A8I3RY66
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

9615:LEO1
gene id: 9615:LEO1
uniprot id: A0A8C0TPB6
uniprot id: A0A8I3PZU5
names: Similarity
messages: Belongs to the LEO1 family.

9615:GRAMD1B
gene id: 9615:GRAMD1B
uniprot id: A0A8I3NQ48
uniprot id: A0A8P0SW09
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:NNAT
gene id: 9615:NNAT
uniprot id: A0A8C0SZY5
names: Similarity
messages: Belongs to the neuronatin family.

9615:CYBA
gene id: 9615:CYBA
uniprot id: A7E3M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9615:RARA
gene id: 9615:RARA
uniprot id: Q5FBR4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated; acetylation is increased upon pulsatile shear stress and decreased upon oscillatory shear stress.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Heterodimer; with RXRA (By similarity). Binds DNA preferentially as a heterodimer (By similarity). RXRA serves as enhancer to induce RARA binding to RARE (By similarity). Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes (By similarity). Interacts with NCOA7 in a ligand-inducible manner (By similarity). Interacts (via the ligand-binding domain) with PRAME; interaction is direct and ligand (retinoic acid)-dependent (By similarity). Interacts with PRKAR1A; the interaction negatively regulates RARA transcriptional activity (By similarity). Interacts with NCOR1 and NCOR2; the interaction occurs in the absence of ligand and represses transcriptional activity (By similarity). Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes (By similarity). Interacts with CDK7; the interaction is enhanced by interaction with GTF2H3 (By similarity). Interacts with GTF2H3; the interaction requires prior phosphorylation on Ser-369 which then enhances interaction with CDK7. Interacts with PRMT2 (By similarity). Interacts with LRIF1 (By similarity). Interacts with ASXL1 and NCOA1 (By similarity). Interacts with ACTN4 (By similarity). In a complex with HDAC3, HDAC5 and HDAC7; the HDACs serve as corepressors of RARA, causing its deacetylation and inhibition of RARE DNA element binding; association with HDAC3, HDAC5 and HDAC7 is increased upon oscillatory shear stress (By similarity). In the absence of hormonal ligand, interacts with TACC1 (By similarity).
messages: Nucleus
messages: Phosphorylated on serine and threonine residues. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for the N-terminal AF1 transcriptional activity. Under stress conditions, MAPK8 enhances phosphorylation on Thr-181, Ser-445 and Ser-461 leading to RARA ubiquitination and degradation. Phosphorylation by AKT1 inhibits the transactivation activity. On retinoic acid stimulation, phosphorylation on Ser-369 by RPS6KA5 promotes interaction with GTF2H3 and the CDK7-mediated phosphorylation of Ser-77 (By similarity).
messages: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Formation of heterocomplex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (By similarity). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (By similarity). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (By similarity).
messages: Sumoylated with SUMO2, mainly on Lys-399 which is also required for SENP6 binding. On all-trans retinoic acid (ATRA) binding, a confromational change may occur that allows sumoylation on two additional site, Lys-166 and Lys-171. Probably desumoylated by SENP6. Sumoylation levels determine nuclear localization and regulate ATRA-mediated transcriptional activity (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9615:BMT2
gene id: 9615:BMT2
uniprot id: A0A8P0TIQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

9615:SNX14
gene id: 9615:SNX14
uniprot id: A0A8I3NQ11
names: Similarity
messages: Belongs to the sorting nexin family.

9615:KCNH5
gene id: 9615:KCNH5
uniprot id: A0A8C0PAV0
uniprot id: A0A8I3S7S4
names: Subcellular Location Annotation
messages: Membrane

9615:SDE2
gene id: 9615:SDE2
uniprot id: A0A8C0MCV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

9615:CYP7A1
gene id: 9615:CYP7A1
uniprot id: A0A8C0SS44
uniprot id: A0A8I3PVJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9615:B3GALT6
gene id: 9615:B3GALT6
uniprot id: Q257A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:CA5B
gene id: 9615:CA5B
uniprot id: A0A8C0SJ70
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9615:RRAD
gene id: 9615:RRAD
uniprot id: A0A8C0MYW7
uniprot id: A0A8I3NBE9
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9615:OCLN
gene id: 9615:OCLN
uniprot id: Q28269
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Dephosphorylated by PTPRJ (By similarity). Less-phosphorylated forms are found in basolateral membrane, cytosol and tight junction. More-heavily phosphorylated forms are concentrated exclusively in tight junction.
messages: Interacts with TJP1/ZO1. Interacts with VAPA. Interacts with CLDN1, CLDN6, CLDN9, CLDN11, CLDN12 and CLDN17. Interacts with PLSCR1. Interacts with LSR, ILDR1 and ILDR2. Interacts with TJP2/ZO2 (By similarity).
messages: Localized at tight junctions of both epithelial and endothelial cells.
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Interacts with ZO-1.
messages: The C-terminal is cytoplasmic and is important for interaction with ZO-1. Necessary for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity).
messages: tight junction

9615:PPP1R3B
gene id: 9615:PPP1R3B
uniprot id: A0A8C0P5H8
uniprot id: A0A8I3NCV8
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9615:BASP1
gene id: 9615:BASP1
uniprot id: A0A8C0YYN1
names: Similarity
messages: Belongs to the BASP1 family.

9615:ANAPC11
gene id: 9615:ANAPC11
uniprot id: A0A8C0NL52
uniprot id: A0A8I3N198
names: Similarity
messages: Belongs to the RING-box family.

9615:AK2
gene id: 9615:AK2
uniprot id: A0A8C0RKH8
uniprot id: A0A8I3MQ78
uniprot id: A0A8I3MXG5
uniprot id: A0A8P0PS80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9615:GRIN2B
gene id: 9615:GRIN2B
uniprot id: Q5R1P3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily.
messages: Cell membrane
messages: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (By similarity). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).
messages: Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro). Can also form heterotetrameric channels that contain at least one zeta subunit (GRIN1), at least one epsilon subunit, plus GRIN3A or GRIN3B. In vivo, the subunit composition may depend on the expression levels of the different subunits. Found in a complex with GRIN1, GRIN3A and PPP2CB. Found in a complex with GRIN1 and GRIN3B. Interacts with MAGI3. Interacts with HIP1 and Neto1. Interacts with PDZ domains of PATJ, DLG3 and DLG4. Interacts with DAPK1 (By similarity). Found in a complex with GRIN1 and PRR7. Interacts with PRR7 (By similarity). Interacts with CAMK2A (By similarity). Interacts with ARC; preventing ARC oligomerization (By similarity). Interacts with TMEM25 (By similarity).
messages: Late endosome
messages: Lysosome
messages: Phosphorylated on tyrosine residues (By similarity). Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity (By similarity).
messages: Postsynaptic cell membrane
messages: cytoskeleton

9615:LOC481650
gene id: 9615:LOC481650
uniprot id: A0A8C0NZP1
uniprot id: A0A8I3NGJ8
names: Similarity
messages: Belongs to the NipSnap family.

9615:KCNJ14
gene id: 9615:KCNJ14
uniprot id: A0A8C0N6M7
uniprot id: A0A8I3RRG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9615:FAM234B
gene id: 9615:FAM234B
uniprot id: A0A8C0TP19
uniprot id: A0A8I3PEM2
names: Similarity
messages: Belongs to the FAM234 family.

9615:SPINK4
gene id: 9615:SPINK4
uniprot id: A0A8I3P8D3
uniprot id: A0A8P0S7Q8
names: Subcellular Location Annotation
messages: Secreted

9615:PEAR1
gene id: 9615:PEAR1
uniprot id: A0A8P0T2J6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:DPM3
gene id: 9615:DPM3
uniprot id: A0A8C0PCX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

9615:STX7
gene id: 9615:STX7
uniprot id: A0A8C0YXM9
uniprot id: A0A8I3MUA1
names: Similarity
messages: Belongs to the syntaxin family.

9615:MCL1
gene id: 9615:MCL1
uniprot id: A0A8C0MD43
uniprot id: A0A8I3P430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Membrane
messages: nucleoplasm

9615:VIP
gene id: 9615:VIP
uniprot id: A0A8C0Z0H7
uniprot id: A0A8I3MUL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9615:SESN3
gene id: 9615:SESN3
uniprot id: A0A8C0NQ27
uniprot id: A0A8I3NX72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9615:MSRB2
gene id: 9615:MSRB2
uniprot id: A0A8C0Q9V7
uniprot id: A0A8I3N101
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9615:SSH1
gene id: 9615:SSH1
uniprot id: A0A8C0PMP2
uniprot id: A0A8C0RU97
uniprot id: A0A8C0Z4A4
uniprot id: A0A8I3PS82
uniprot id: A0A8I3PWB1
uniprot id: A0A8I3Q8T6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9615:SNRPC
gene id: 9615:SNRPC
uniprot id: E2RGI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA (By similarity). Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites (By similarity).
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus

9615:DDAH1
gene id: 9615:DDAH1
uniprot id: A0A8C0RLC5
uniprot id: A0A8I3MGE2
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9615:PAXBP1
gene id: 9615:PAXBP1
uniprot id: A0A8C0TU43
uniprot id: A0A8I3PXQ4
names: Similarity
messages: Belongs to the GCF family.

9615:MAP2K5
gene id: 9615:MAP2K5
uniprot id: A0A8C0MYZ5
uniprot id: A0A8C0TXV1
uniprot id: A0A8I3NYD3
uniprot id: A0A8I3P4L6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:UROD
gene id: 9615:UROD
uniprot id: A0A8C0T4X5
uniprot id: A0A8I3PMG0
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

9615:MARCO
gene id: 9615:MARCO
uniprot id: A0A8C0PB10
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:PRKRIP1
gene id: 9615:PRKRIP1
uniprot id: A0A8P0SQZ3
names: Similarity
messages: Belongs to the PRKRIP1 family.

9615:UXT
gene id: 9615:UXT
uniprot id: A0A8C0T2G7
names: Similarity
messages: Belongs to the UXT family.

9615:MTX3
gene id: 9615:MTX3
uniprot id: A0A8C0NML1
uniprot id: A0A8C0RXN4
uniprot id: A0A8I3N4P9
uniprot id: A0A8I3RUM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:SUOX
gene id: 9615:SUOX
uniprot id: A0A8C0RXB4
uniprot id: A0A8P0N3B7
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
messages: Mitochondrion intermembrane space

9615:EEF1B2
gene id: 9615:EEF1B2
uniprot id: A0A8C0RFS6
uniprot id: A0A8I3PJ02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9615:PFKFB1
gene id: 9615:PFKFB1
uniprot id: A0A8C0TK23
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9615:TM4SF20
gene id: 9615:TM4SF20
uniprot id: A0A8C0TAS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9615:FANCM
gene id: 9615:FANCM
uniprot id: A0A8P0NSJ1
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

9615:VPS37B
gene id: 9615:VPS37B
uniprot id: A0A8C0TP28
uniprot id: A0A8I3S1J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9615:SLC13A1
gene id: 9615:SLC13A1
uniprot id: A0A8C0NI06
uniprot id: A0A8I3NZ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9615:IL36B
gene id: 9615:IL36B
uniprot id: A0A8C0MA46
uniprot id: A0A8I3NL49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9615:ENKD1
gene id: 9615:ENKD1
uniprot id: A0A8C0NUA9
uniprot id: A0A8I3MZ13
names: Subcellular Location Annotation
messages: cilium axoneme

9615:ZDHHC24
gene id: 9615:ZDHHC24
uniprot id: A0A8C0NS22
uniprot id: A0A8I3NE70
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:OR13C1
gene id: 9615:OR13C1
uniprot id: A0A8P0SUL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:GJA10
gene id: 9615:GJA10
uniprot id: A0A8C0SF09
uniprot id: A0A8I3N9K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:LIG4
gene id: 9615:LIG4
uniprot id: A0A8C0M8R8
uniprot id: A0A8I3PV38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9615:CXCL12
gene id: 9615:CXCL12
uniprot id: A0A8C0NWR9
uniprot id: A0A8C0NYU3
uniprot id: Q3LSL4
uniprot id: Q3LSL5
uniprot id: Q5XNN9
names: Similarity
messages: Belongs to the intercrine alpha (chemokine CxC) family.

9615:CCDC90B
gene id: 9615:CCDC90B
uniprot id: A0A8C0M7B6
names: Similarity
messages: Belongs to the CCDC90 family.

9615:ALDH3A1
gene id: 9615:ALDH3A1
uniprot id: A3RF36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
messages: Belongs to the aldehyde dehydrogenase family.
messages: Cytoplasm
messages: Homodimer.

9615:TRAPPC1
gene id: 9615:TRAPPC1
uniprot id: A0A8C0RZV3
uniprot id: A0A8I3PU34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9615:GGACT
gene id: 9615:GGACT
uniprot id: A0A8C0MH61
uniprot id: A0A8I3PIL7
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9615:PIWIL1
gene id: 9615:PIWIL1
uniprot id: A0A8P0SC51
uniprot id: E2RDI9
names: Similarity
messages: Belongs to the argonaute family.

9615:HOXC6
gene id: 9615:HOXC6
uniprot id: A0A8C0T8M4
uniprot id: A0A8I3NVN6
names: Subcellular Location Annotation
messages: Nucleus

9615:ADAMTS14
gene id: 9615:ADAMTS14
uniprot id: A0A8C0NA17
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:FTO
gene id: 9615:FTO
uniprot id: A0A8I3MHQ3
uniprot id: A0A8P0PAI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fto family.
messages: Cytoplasm
messages: Nucleus speckle

9615:RNASET2
gene id: 9615:RNASET2
uniprot id: A0A8C0REG3
uniprot id: A0A8I3MTH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Lysosome lumen

9615:CD52
gene id: 9615:CD52
uniprot id: Q28896
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Epididymis. Highest levels are found in the distal corpus and cauda. Little or no expression in the caput and proximal cauda regions.
messages: May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

9615:DCP1B
gene id: 9615:DCP1B
uniprot id: A0A8C0NWR1
uniprot id: A0A8I3QAS7
names: Similarity
messages: Belongs to the DCP1 family.

9615:CDKAL1
gene id: 9615:CDKAL1
uniprot id: J7MDG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

9615:HPDL
gene id: 9615:HPDL
uniprot id: A0A8C0T247
uniprot id: A0A8I3PQJ0
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9615:SGK3
gene id: 9615:SGK3
uniprot id: A0A8C0TA93
uniprot id: D7NGX9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9615:SKA3
gene id: 9615:SKA3
uniprot id: A0A8C0PAE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

9615:CHRM2
gene id: 9615:CHRM2
uniprot id: A0A8I3N4M6
uniprot id: A0A8P0PP20
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9615:GTF2A1L
gene id: 9615:GTF2A1L
uniprot id: A0A8C0MPA4
uniprot id: A0A8I3N1G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9615:FZD9
gene id: 9615:FZD9
uniprot id: A0A8P0SHS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9615:TOMM7
gene id: 9615:TOMM7
uniprot id: A0A8C0PNC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:STARD3NL
gene id: 9615:STARD3NL
uniprot id: A0A8C0P9E4
uniprot id: A0A8I3PML6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Membrane

9615:GRPEL1
gene id: 9615:GRPEL1
uniprot id: A0A8I3N3U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9615:FOXP4
gene id: 9615:FOXP4
uniprot id: A0A8C0MKR4
uniprot id: A0A8I3NLA6
names: Subcellular Location Annotation
messages: Nucleus

9615:PSMB7
gene id: 9615:PSMB7
uniprot id: E7BUQ0
names: Subcellular Location Annotation
messages: Nucleus

9615:BCOR
gene id: 9615:BCOR
uniprot id: A0A8I3PY93
uniprot id: A0A8I3PYM1
uniprot id: A0A8P0PNJ5
uniprot id: A0A8P0TRJ5
names: Similarity
messages: Belongs to the BCOR family.

9615:MCOLN2
gene id: 9615:MCOLN2
uniprot id: A0A8C0NCC2
uniprot id: A0A8I3MYU1
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9615:OXSR1
gene id: 9615:OXSR1
uniprot id: A0A8C0MQ01
uniprot id: A0A8C0MTR0
uniprot id: A0A8I3QWE2
uniprot id: A0A8I3S7C3
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9615:MMP11
gene id: 9615:MMP11
uniprot id: A0A8C0TA21
uniprot id: A0A8I3PMD6
uniprot id: D9IQ20
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9615:PRPSAP1
gene id: 9615:PRPSAP1
uniprot id: A0A8P0SYU6
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9615:CSTF1
gene id: 9615:CSTF1
uniprot id: A0A8C0PJK5
uniprot id: A0A8I3Q2Q2
names: Subcellular Location Annotation
messages: Nucleus

9615:ZSCAN25
gene id: 9615:ZSCAN25
uniprot id: A0A8I3MNB2
uniprot id: A0A8I3MS56
uniprot id: A0A8P0NGQ0
names: Subcellular Location Annotation
messages: Nucleus

9615:NOX3
gene id: 9615:NOX3
uniprot id: A7E3L1
names: Subcellular Location Annotation
messages: Membrane

9615:POLL
gene id: 9615:POLL
uniprot id: A0A8C0NGK7
uniprot id: A0A8C0TAZ6
uniprot id: A0A8I3P5V8
uniprot id: A0A8I3S4K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9615:SMARCA4
gene id: 9615:SMARCA4
uniprot id: A0A8C0T0C2
uniprot id: A0A8I3PJ19
uniprot id: A0A8I3PJC1
uniprot id: A0A8P0NWF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9615:HOXB9
gene id: 9615:HOXB9
uniprot id: A0A8C0Q7U4
uniprot id: A0A8I3N8G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9615:POMK
gene id: 9615:POMK
uniprot id: A0A8C0PGD1
uniprot id: A0A8C0SYF8
uniprot id: A0A8I3NRN3
uniprot id: A0A8I3NW28
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.

9615:MTMR6
gene id: 9615:MTMR6
uniprot id: A0A8I3PDD0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9615:RAB5C
gene id: 9615:RAB5C
uniprot id: P51147
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Early endosome membrane
messages: Interacts with EEA1 and INCA1 (By similarity). Interacts with GDI1, GDI2, CHML and CHM; phosphorylation at Ser-85 disrupts this interaction (By similarity).
messages: Melanosome
messages: Phosphorylation of Ser-85 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Protein transport. Probably involved in vesicular traffic.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.

9615:MAGOH
gene id: 9615:MAGOH
uniprot id: A0A8C0RCD0
uniprot id: A0A8I3P1R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9615:SEC16B
gene id: 9615:SEC16B
uniprot id: A0A8C0QG11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

9615:ADGRE2
gene id: 9615:ADGRE2
uniprot id: Q2Q421
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Binding to chondroitin sulfate is mediated by the fourth EGF domain.
messages: Cell membrane
messages: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins.
messages: Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is calcium-dependent. Interacts with CD55.
messages: The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.
messages: ruffle membrane

9615:HOXC11
gene id: 9615:HOXC11
uniprot id: A0A8C0T7L7
uniprot id: A0A8I3P6Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9615:PRPF38A
gene id: 9615:PRPF38A
uniprot id: A0A8C0N1M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9615:MED7
gene id: 9615:MED7
uniprot id: A0A8C0RGW9
uniprot id: A0A8I3MG00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9615:DYNLT3
gene id: 9615:DYNLT3
uniprot id: Q8SPS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).
messages: Belongs to the dynein light chain Tctex-type family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA (By similarity).
messages: Nucleus
messages: cytoskeleton
messages: kinetochore

9615:LPCAT1
gene id: 9615:LPCAT1
uniprot id: A0A8C0TQH8
uniprot id: A0A8C0TQJ0
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9615:DCN
gene id: 9615:DCN
uniprot id: Q29393
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).
messages: May affect the rate of fibrils formation.
messages: Secreted
messages: The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
messages: extracellular matrix

9615:DMRTA1
gene id: 9615:DMRTA1
uniprot id: A0A8P0S7K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9615:EYA3
gene id: 9615:EYA3
uniprot id: A0A8C0MXG9
uniprot id: A0A8I3NIX5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9615:RACK1
gene id: 9615:RACK1
uniprot id: A0A8C0N4R3
uniprot id: A0A8I3RSQ2
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

9615:TLN1
gene id: 9615:TLN1
uniprot id: A0A8C0SER8
uniprot id: A0A8I3N6K0
names: Subcellular Location Annotation
messages: cytoskeleton

9615:MCHR1
gene id: 9615:MCHR1
uniprot id: A0A8C0PB68
uniprot id: Q8MIP6
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

9615:OVOL1
gene id: 9615:OVOL1
uniprot id: A0A8C0SRK6
uniprot id: A0A8I3PB55
names: Subcellular Location Annotation
messages: Nucleus

9615:RAP2C
gene id: 9615:RAP2C
uniprot id: A0A8C0TKJ8
uniprot id: A0A8I3QCP6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9615:IAPP
gene id: 9615:IAPP
uniprot id: P17716
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calcitonin family.
messages: Interacts with IDE and INS.
messages: Secreted
messages: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
messages: The mature protein is largely unstructured in the absence of a cognate ligand.

9615:RHOT1
gene id: 9615:RHOT1
uniprot id: A0A8C0NAB6
uniprot id: A0A8C0NDQ9
uniprot id: A0A8C0NFZ8
uniprot id: A0A8C0RKH2
uniprot id: A0A8I3NRK8
uniprot id: A0A8I3RXF7
uniprot id: A0A8I3RZR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9615:KRT84
gene id: 9615:KRT84
uniprot id: A0A8C0T0G6
names: Similarity
messages: Belongs to the intermediate filament family.

9615:BCL2
gene id: 9615:BCL2
uniprot id: Q75SV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Nucleus membrane

9615:TGIF2
gene id: 9615:TGIF2
uniprot id: A0A8C0SCM7
uniprot id: A0A8I3PWZ5
names: Subcellular Location Annotation
messages: Nucleus

9615:TGS1
gene id: 9615:TGS1
uniprot id: A0A8C0TW44
uniprot id: A0A8I3PUL6
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9615:TRPM8
gene id: 9615:TRPM8
uniprot id: Q1A7N1
names: Subcellular Location Annotation
messages: Membrane

9615:CLCC1
gene id: 9615:CLCC1
uniprot id: A0A8P0NL19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane

9615:NT5C3A
gene id: 9615:NT5C3A
uniprot id: A0A8C0N924
uniprot id: A0A8C0QQ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9615:TAS2R39
gene id: 9615:TAS2R39
uniprot id: A0A8C0Q8Y4
uniprot id: Q2ABD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:SUGP1
gene id: 9615:SUGP1
uniprot id: A0A8C0N7X5
uniprot id: A0A8I3S0X7
names: Subcellular Location Annotation
messages: Nucleus

9615:GATC
gene id: 9615:GATC
uniprot id: A0A8C0T6Y4
uniprot id: A0A8I3Q2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9615:ENTPD1
gene id: 9615:ENTPD1
uniprot id: A0A8C0PFT7
uniprot id: A0A8C0PG00
uniprot id: A0A8C0TQB2
uniprot id: A0A8I3PR21
uniprot id: A0A8I3Q7F5
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9615:B4GALT4
gene id: 9615:B4GALT4
uniprot id: B2G3R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9615:ERRFI1
gene id: 9615:ERRFI1
uniprot id: A0A8C0SGD8
uniprot id: A0A8I3S6C0
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9615:CA9
gene id: 9615:CA9
uniprot id: A0A8C0RHE4
uniprot id: A0A8I3NCN1
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9615:BTAF1
gene id: 9615:BTAF1
uniprot id: A0A8C0NHA6
uniprot id: A0A8I3Q2K3
names: Subcellular Location Annotation
messages: Nucleus

9615:GRWD1
gene id: 9615:GRWD1
uniprot id: A0A8C0RVA6
names: Subcellular Location Annotation
messages: Nucleus

9615:STK4
gene id: 9615:STK4
uniprot id: A0A8C0TTC2
uniprot id: A0A8I3NQ71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9615:GLRA2
gene id: 9615:GLRA2
uniprot id: A0A8C0SDM5
uniprot id: A0A8I3QS28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9615:CAMK1
gene id: 9615:CAMK1
uniprot id: A0A8C0TTB3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:CLDN3
gene id: 9615:CLDN3
uniprot id: Q95KM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).
messages: Cell membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:SEMA3D
gene id: 9615:SEMA3D
uniprot id: A0A8C0N1G0
uniprot id: A0A8I3Q2U6
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:AOX2
gene id: 9615:AOX2
uniprot id: Q2QB47
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9615:MRPL3
gene id: 9615:MRPL3
uniprot id: A0A8C0TBA8
uniprot id: A0A8I3Q1K3
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9615:CEP162
gene id: 9615:CEP162
uniprot id: A0A8C0MFJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

9615:LOC610181
gene id: 9615:LOC610181
uniprot id: Q5TJE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits (By similarity). Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92 (By similarity).

9615:PIGS
gene id: 9615:PIGS
uniprot id: A0A8C0TB26
uniprot id: A0A8I3N4K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:KIF2C
gene id: 9615:KIF2C
uniprot id: A0A8C0RKF8
uniprot id: A0A8I3Q0S1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:ARPC1A
gene id: 9615:ARPC1A
uniprot id: A0A8C0NSU7
uniprot id: A0A8I3MPK0
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

9615:UTP3
gene id: 9615:UTP3
uniprot id: A0A8C0QBL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAS10 family.
messages: nucleolus

9615:EIF2B1
gene id: 9615:EIF2B1
uniprot id: A0A8C0Z5H2
uniprot id: A0A8I3P3X9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

9615:CDIP1
gene id: 9615:CDIP1
uniprot id: A0A8C0YY01
uniprot id: A0A8I3MIL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9615:ATG16L1
gene id: 9615:ATG16L1
uniprot id: A0A8C0P7K5
uniprot id: A0A8I3PHQ4
uniprot id: A0A8I3S4X7
uniprot id: A0A8I3S4Z7
uniprot id: A0A8P0NDN0
uniprot id: A0A8P0TAN3
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9615:SLC9A8
gene id: 9615:SLC9A8
uniprot id: A0A8P0NDH3
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

9615:U2AF2
gene id: 9615:U2AF2
uniprot id: A0A8C0LZ00
uniprot id: A0A8I3RP62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

9615:BGN
gene id: 9615:BGN
uniprot id: O02678
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity).
messages: May be involved in collagen fiber assembly.
messages: The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.
messages: extracellular matrix

9615:SLC1A1
gene id: 9615:SLC1A1
uniprot id: Q9N1R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9615:ATXN2L
gene id: 9615:ATXN2L
uniprot id: A0A8C0LTZ1
uniprot id: A0A8C0R9B6
names: Similarity
messages: Belongs to the ataxin-2 family.

9615:PDE7A
gene id: 9615:PDE7A
uniprot id: A0A8C0T5T8
uniprot id: A0A8I3S384
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:LHX2
gene id: 9615:LHX2
uniprot id: A0A8C0PPM4
uniprot id: A0A8I3RW43
names: Subcellular Location Annotation
messages: Nucleus

9615:SUMO1
gene id: 9615:SUMO1
uniprot id: A0A8C0RNS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9615:H3C13
gene id: 9615:H3C13
uniprot id: A0A8C0QMM4
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:GOLGA5
gene id: 9615:GOLGA5
uniprot id: A0A8C0Z188
uniprot id: A0A8I3S5E8
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

9615:ATP1B2
gene id: 9615:ATP1B2
uniprot id: A0A8C0NJN6
uniprot id: A0A8I3PRQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9615:ITGA2
gene id: 9615:ITGA2
uniprot id: A0A8C0S0G4
uniprot id: A0A8I3MC22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:GRIA3
gene id: 9615:GRIA3
uniprot id: A0A8C0SX82
uniprot id: A0A8C0SXI9
uniprot id: A0A8I3PJ11
uniprot id: A0A8I3PN71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9615:SEMA4F
gene id: 9615:SEMA4F
uniprot id: A0A8C0QBD4
uniprot id: A0A8C0QBJ9
uniprot id: A0A8I3NZS3
uniprot id: A0A8I3P073
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CYYR1
gene id: 9615:CYYR1
uniprot id: A0A8C0TGJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYYR1 family.
messages: Membrane

9615:COX14
gene id: 9615:COX14
uniprot id: A0A8C0PPC5
names: Subcellular Location Annotation
messages: Membrane

9615:ABRAXAS2
gene id: 9615:ABRAXAS2
uniprot id: A0A8C0Z383
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abro1 subfamily.
messages: Nucleus
messages: spindle pole

9615:MYO3B
gene id: 9615:MYO3B
uniprot id: A0A8I3PV92
uniprot id: A0A8I3S588
uniprot id: A0A8P0PLC5
uniprot id: A0A8P0PS39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

9615:MYLK
gene id: 9615:MYLK
uniprot id: A0A8I3PTT4
uniprot id: A0A8P0PD71
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

9615:VRK1
gene id: 9615:VRK1
uniprot id: A0A8C0PUR1
uniprot id: A0A8I3MQW3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:TM4SF4
gene id: 9615:TM4SF4
uniprot id: A0A8C0MUM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9615:SRPRB
gene id: 9615:SRPRB
uniprot id: A0A8C0MVG1
uniprot id: A0A8I3Q3L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:NQO1
gene id: 9615:NQO1
uniprot id: A0A8I3NAN7
uniprot id: A0A8P0P4K3
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9615:KIN
gene id: 9615:KIN
uniprot id: A0A8C0LVP7
names: Similarity
messages: Belongs to the KIN17 family.

9615:RFX3
gene id: 9615:RFX3
uniprot id: A0A8C0Q5D7
uniprot id: A0A8I3MU48
uniprot id: A0A8P0P6J7
names: Subcellular Location Annotation
messages: Nucleus

9615:NMNAT3
gene id: 9615:NMNAT3
uniprot id: A0A8I3PTJ4
uniprot id: A0A8I3PU25
uniprot id: A0A8P0TJL1
uniprot id: A0A8P0TM45
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9615:STX16
gene id: 9615:STX16
uniprot id: A0A8C0NM40
uniprot id: A0A8C0RMQ0
uniprot id: A0A8C0T283
uniprot id: A0A8I3NME0
uniprot id: A0A8I3NQH2
uniprot id: A0A8I3NQI7
uniprot id: A0A8P0NSG8
uniprot id: A0A8P0SGW5
uniprot id: A0A8P0T0W8
names: Similarity
messages: Belongs to the syntaxin family.

9615:GJB6
gene id: 9615:GJB6
uniprot id: A0A654ICT8
uniprot id: A0A8P0TM53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:CLUL1
gene id: 9615:CLUL1
uniprot id: Q95KN1
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the clusterin family.
messages: Retina-specific (at protein level). In the light-adapted retina, expressed in the outer segment of cone photoreceptors. In the dark-adapted retina, strongly expressed in the outer plexiform layer in the region of contact between the cone pedicles and second order neurons with little or no expression in the cone photoreceptor outer segments.
messages: Secreted

9615:GNAQ
gene id: 9615:GNAQ
uniprot id: Q28294
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Binds NHERF1. Forms a complex with PECAM1 and BDKRB2. Interacts with PECAM1 (By similarity). Interacts with GAS2L2 (By similarity).
messages: Golgi apparatus
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Required for platelet activation. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNA11, required for heart development (By similarity).
messages: Histaminylated at Gln-209 residues by TGM2.
messages: Nucleus
messages: Nucleus membrane
messages: Palmitoylated by ZDHHC3 and ZDHHC7. Palmitoylation occurs in the Golgi and participates in the localization of GNAQ to the plasma membrane.

9615:LOXL2
gene id: 9615:LOXL2
uniprot id: A0A8C0RPV7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9615:PIAS3
gene id: 9615:PIAS3
uniprot id: A0A8I3NGF6
uniprot id: A0A8P0P4B4
names: Similarity
messages: Belongs to the PIAS family.

9615:GK
gene id: 9615:GK
uniprot id: A0A8C0SCZ4
uniprot id: A0A8I3NWT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9615:B4GALT2
gene id: 9615:B4GALT2
uniprot id: A0A8C0NFM5
uniprot id: A0A8I3Q406
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9615:DLA-DRA
gene id: 9615:DLA-DRA
uniprot id: A0A8C0RKX0
uniprot id: Q30437
names: Similarity
messages: Belongs to the MHC class II family.

9615:EIF2B2
gene id: 9615:EIF2B2
uniprot id: A0A8C0SJF8
uniprot id: A0A8I3NV56
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9615:DGKG
gene id: 9615:DGKG
uniprot id: A0A8C0SQP6
uniprot id: A0A8I3NZ70
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9615:NUBP1
gene id: 9615:NUBP1
uniprot id: A0A8C0QFE4
uniprot id: A0A8I3NFS3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9615:CHRNB4
gene id: 9615:CHRNB4
uniprot id: A0A8C0TE45
uniprot id: A0A8I3NCE4
uniprot id: A0A8P0TEX7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:ABCC2
gene id: 9615:ABCC2
uniprot id: Q9GK09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9615:STK38
gene id: 9615:STK38
uniprot id: A0A8C0MX62
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:KRT17
gene id: 9615:KRT17
uniprot id: A0A8C0S7D0
names: Similarity
messages: Belongs to the intermediate filament family.

9615:EBP
gene id: 9615:EBP
uniprot id: A0A8P0PEA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:SH3BGRL3
gene id: 9615:SH3BGRL3
uniprot id: A0A8C0Q229
uniprot id: A0A8I3NJI4
names: Similarity
messages: Belongs to the SH3BGR family.

9615:ETV7
gene id: 9615:ETV7
uniprot id: A0A8C0N271
uniprot id: A0A8I3N7G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:ST8SIA4
gene id: 9615:ST8SIA4
uniprot id: A0A8C0NMC0
uniprot id: A0A8I3MRS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:NDUFV2
gene id: 9615:NDUFV2
uniprot id: A0A8C0MGU4
uniprot id: A0A8I3MKY6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9615:PIGU
gene id: 9615:PIGU
uniprot id: A0A8C0RZK0
uniprot id: A0A8I3S213
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:CLCN6
gene id: 9615:CLCN6
uniprot id: A0A8C0NIH8
uniprot id: A0A8I3MK25
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:PEX5
gene id: 9615:PEX5
uniprot id: A0A8C0TIZ1
uniprot id: A0A8I3PH40
uniprot id: A0A8I3PQB5
uniprot id: A0A8P0SIS8
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9615:TG
gene id: 9615:TG
uniprot id: Q1ERT3
names: Caution
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CPSF3
gene id: 9615:CPSF3
uniprot id: A0A8C0QCK4
names: Subcellular Location Annotation
messages: Nucleus

9615:ZW10
gene id: 9615:ZW10
uniprot id: A0A8C0Q002
uniprot id: A0A8I3RP75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

9615:FNTA
gene id: 9615:FNTA
uniprot id: A0A8C0RQI5
uniprot id: A0A8I3P9P2
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9615:NDUFS4
gene id: 9615:NDUFS4
uniprot id: A0A8C0QK35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

9615:CTU2
gene id: 9615:CTU2
uniprot id: A0A8C0NP19
uniprot id: A0A8I3RSU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTU2/NCS2 family.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9615:NAT10
gene id: 9615:NAT10
uniprot id: A0A8C0P9F5
uniprot id: A0A8I3PQ87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9615:TMEM208
gene id: 9615:TMEM208
uniprot id: A0A8C0N169
uniprot id: A0A8I3N6V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9615:DYNLT4
gene id: 9615:DYNLT4
uniprot id: A0A8C0T510
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9615:JMJD1C
gene id: 9615:JMJD1C
uniprot id: A0A8C0PSY8
uniprot id: A0A8I3RQX1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9615:EFTUD2
gene id: 9615:EFTUD2
uniprot id: A0A8C0SJ19
uniprot id: A0A8I3MU66
names: Subcellular Location Annotation
messages: Nucleus

9615:PHKB
gene id: 9615:PHKB
uniprot id: A0A8C0T6A9
uniprot id: A0A8I3NA07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9615:IGF2BP1
gene id: 9615:IGF2BP1
uniprot id: A0A8C0Q723
uniprot id: A0A8I3NB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9615:LOC487951
gene id: 9615:LOC487951
uniprot id: A0A8C0TMH2
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

9615:PYGL
gene id: 9615:PYGL
uniprot id: A0A8C0Q1A8
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9615:DBI
gene id: 9615:DBI
uniprot id: Q9TQX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ACBP family.
messages: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Monomer.

9615:CHRNA6
gene id: 9615:CHRNA6
uniprot id: A0A8C0Q1H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:IL1RL1
gene id: 9615:IL1RL1
uniprot id: A0A8C0QGS0
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9615:SLCO1B3
gene id: 9615:SLCO1B3
uniprot id: A0A8I3NUI6
uniprot id: A0A8P0T8N4
uniprot id: C9EGT7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:CREB1
gene id: 9615:CREB1
uniprot id: A0A8C0N7M6
uniprot id: A0A8C0TY64
uniprot id: A0A8I3PDE7
uniprot id: A0A8I3S2U7
names: Subcellular Location Annotation
messages: Nucleus

9615:C1QBP
gene id: 9615:C1QBP
uniprot id: A0A8C0P0Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Cell membrane

9615:TRIM54
gene id: 9615:TRIM54
uniprot id: A0A8C0S197
uniprot id: A0A8I3N499
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9615:STAC3
gene id: 9615:STAC3
uniprot id: A0A8C0SDL4
names: Subcellular Location Annotation
messages: sarcolemma

9615:PLAC8A
gene id: 9615:PLAC8A
uniprot id: A0A8C0TNJ1
names: Similarity
messages: Belongs to the cornifelin family.

9615:TMEM151A
gene id: 9615:TMEM151A
uniprot id: A0A8C0SGY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9615:ARL5B
gene id: 9615:ARL5B
uniprot id: A0A8C0PTF3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9615:THOC5
gene id: 9615:THOC5
uniprot id: A0A8C0PCD0
uniprot id: A0A8C0PFN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9615:ITM2C
gene id: 9615:ITM2C
uniprot id: A0A8I3PI18
uniprot id: A0A8P0TJY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9615:TIMM10B
gene id: 9615:TIMM10B
uniprot id: A0A8C0T8A2
uniprot id: A0A8I3N5Q0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9615:ITGAL
gene id: 9615:ITGAL
uniprot id: A0A8C0SJG3
uniprot id: A0A8I3NS51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:PPT2
gene id: 9615:PPT2
uniprot id: A0A8I3NUN9
uniprot id: A0A8P0PFT6
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9615:KRT33A
gene id: 9615:KRT33A
uniprot id: A0A8C0NL65
names: Similarity
messages: Belongs to the intermediate filament family.

9615:SELL
gene id: 9615:SELL
uniprot id: A0A8C0RUP4
uniprot id: A0A8I3MNI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:DEFB119
gene id: 9615:DEFB119
uniprot id: Q30KT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:TM2D3
gene id: 9615:TM2D3
uniprot id: A0A8C0LYR6
uniprot id: A0A8C0M417
uniprot id: A0A8I3MC56
uniprot id: A0A8I3MG65
names: Subcellular Location Annotation
messages: Membrane

9615:RBM15
gene id: 9615:RBM15
uniprot id: A0A8C0NR66
uniprot id: A0A8I3MEV5
names: Similarity
messages: Belongs to the RRM Spen family.

9615:MYADML2
gene id: 9615:MYADML2
uniprot id: A0A8P0SBC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9615:LOC480492
gene id: 9615:LOC480492
uniprot id: A0A8C0RGG1
uniprot id: J9P5K9
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9615:RPL7L1
gene id: 9615:RPL7L1
uniprot id: A0A8C0RZC7
uniprot id: A0A8I3N6D0
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9615:NOSTRIN
gene id: 9615:NOSTRIN
uniprot id: A0A8C0P9P4
names: Subcellular Location Annotation
messages: cytoskeleton

9615:BMP10
gene id: 9615:BMP10
uniprot id: A0A8C0P7W4
uniprot id: A0A8I3PPQ3
names: Similarity
messages: Belongs to the TGF-beta family.

9615:NIP7
gene id: 9615:NIP7
uniprot id: A0A8C0NAY9
uniprot id: A0A8I3N227
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

9615:DSCC1
gene id: 9615:DSCC1
uniprot id: A0A8C0S8Q1
uniprot id: A0A8I3MVX5
names: Similarity
messages: Belongs to the DCC1 family.

9615:SLC12A1
gene id: 9615:SLC12A1
uniprot id: A0A8P0NT73
uniprot id: A0A8P0P3B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9615:AMBN
gene id: 9615:AMBN
uniprot id: A0A8C0RYE2
uniprot id: A0A8I3NIA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

9615:DUSP13
gene id: 9615:DUSP13
uniprot id: A0A8C0P1G6
uniprot id: A0A8I3RXJ5
uniprot id: A0A8P0T6S4
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9615:MMAB
gene id: 9615:MMAB
uniprot id: A0A8C0TP82
uniprot id: A0A8I3PL52
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

9615:ADIPOR2
gene id: 9615:ADIPOR2
uniprot id: A0A8C0NL83
uniprot id: A0A8I3Q6Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9615:DKKL1
gene id: 9615:DKKL1
uniprot id: A0A8P0N6I0
names: Subcellular Location Annotation
messages: Secreted

9615:ALKBH1
gene id: 9615:ALKBH1
uniprot id: A0A8C0RCW9
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

9615:PARP8
gene id: 9615:PARP8
uniprot id: A0A8P0SY97
names: Similarity
messages: Belongs to the ARTD/PARP family.

9615:FGF1
gene id: 9615:FGF1
uniprot id: A0A8C0QGP1
uniprot id: J9NTP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9615:OR6D7
gene id: 9615:OR6D7
uniprot id: A0A8C0NT13
uniprot id: A0A8I3PYL9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CLASP1
gene id: 9615:CLASP1
uniprot id: A0A8C0P9K6
uniprot id: A0A8I3PLV0
uniprot id: A0A8P0SW86
names: Subcellular Location Annotation
messages: kinetochore

9615:CXCL10
gene id: 9615:CXCL10
uniprot id: Q5KSV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Monomer, dimer, and tetramer. Interacts with CXCR3 (via N-terminus).
messages: Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
messages: Secreted

9615:SPNS3
gene id: 9615:SPNS3
uniprot id: A0A8C0TKI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9615:MICOS13
gene id: 9615:MICOS13
uniprot id: A0A8C0P520
uniprot id: A0A8I3NPT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9615:OR14J1
gene id: 9615:OR14J1
uniprot id: A0A8P0NGK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:RER1
gene id: 9615:RER1
uniprot id: A0A8C0RAD3
uniprot id: A0A8I3P3J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

9615:CORO2A
gene id: 9615:CORO2A
uniprot id: A0A8P0NZR3
names: Similarity
messages: Belongs to the WD repeat coronin family.

9615:KLRD1
gene id: 9615:KLRD1
uniprot id: Q38HS3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Can form disulfide-bonded heterodimer with NKG2 family members KLRC1 and KLRC2. KLRD1-KLRC1 heterodimer interacts with peptide-bound MHC-E-B2M heterotrimeric complex. KLRD1 plays a prominent role in directly interacting with MHC-E. KLRD1-KLRC1 interacts with much higher affinity with peptide-bound MHC-E-B2M than KLRD1-KLRC2. Interacts with the adapter protein TYROBP/DAP12; this interaction is required for cell surface expression and cell activation.
messages: Cell membrane
messages: Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal.
messages: KLRD1-KLRC1 acts as an immune inhibitory receptor. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Upon MHC-E-peptide binding, transmits intracellular signals through KLRC1 immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHIP-1 and INPPL1/SHIP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules.
messages: KLRD1-KLRC2 acts as an immune activating receptor. On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon MHC-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.

9615:DPYSL5
gene id: 9615:DPYSL5
uniprot id: A0A8C0QDP3
uniprot id: A0A8I3SC06
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9615:PAQR4
gene id: 9615:PAQR4
uniprot id: A0A8C0M631
uniprot id: A0A8C0T2M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9615:PSMB5
gene id: 9615:PSMB5
uniprot id: A0A8C0RVG6
uniprot id: A0A8I3MNI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9615:YIPF5
gene id: 9615:YIPF5
uniprot id: A0A8C0QHW2
uniprot id: A0A8I3P483
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9615:CCT4
gene id: 9615:CCT4
uniprot id: A0A8C0NST9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9615:PNP
gene id: 9615:PNP
uniprot id: A0A8C0S933
uniprot id: A0A8I3PKI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9615:OR6C1K
gene id: 9615:OR6C1K
uniprot id: A0A8C0PXC0
uniprot id: A0A8I3NGM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ORAI3
gene id: 9615:ORAI3
uniprot id: A0A8I3NYN0
uniprot id: A0A8P0NRZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9615:ANO5
gene id: 9615:ANO5
uniprot id: A0A8C0NPM4
uniprot id: A0A8I3S651
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9615:CERS5
gene id: 9615:CERS5
uniprot id: A0A8I3P037
uniprot id: A0A8I3P1Y0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9615:ZNF768
gene id: 9615:ZNF768
uniprot id: A0A8C0M461
uniprot id: A0A8I3P145
names: Subcellular Location Annotation
messages: Nucleus

9615:CSTA
gene id: 9615:CSTA
uniprot id: A0A8C0N313
uniprot id: F1PHB6
names: Similarity
messages: Belongs to the cystatin family.

9615:ABITRAM
gene id: 9615:ABITRAM
uniprot id: A0A8C0QRX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9615:ORC4
gene id: 9615:ORC4
uniprot id: A0A8C0TGT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9615:SPAG11B
gene id: 9615:SPAG11B
uniprot id: A0A8C0MV68
uniprot id: Q30KR3
names: Subcellular Location Annotation
messages: Secreted

9615:TMEM230
gene id: 9615:TMEM230
uniprot id: A0A8C0P2P1
uniprot id: A0A8I3QG26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9615:MTERF1
gene id: 9615:MTERF1
uniprot id: A0A8C0MY51
uniprot id: A0A8C0SW36
uniprot id: A0A8I3NK74
names: Similarity
messages: Belongs to the mTERF family.

9615:NDRG1
gene id: 9615:NDRG1
uniprot id: A0A8C0NZL8
uniprot id: L7V3M2
names: Similarity
messages: Belongs to the NDRG family.

9615:METTL26
gene id: 9615:METTL26
uniprot id: A0A8C0N2D2
names: Similarity
messages: Belongs to the UPF0585 family.

9615:TMEM41B
gene id: 9615:TMEM41B
uniprot id: A0A8C0RER8
uniprot id: A0A8I3P070
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9615:COA7
gene id: 9615:COA7
uniprot id: A0A8C0S5A3
uniprot id: A0A8I3S317
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space
messages: Required for assembly of mitochondrial respiratory chain complexes.

9615:FOLH1B
gene id: 9615:FOLH1B
uniprot id: I4IY07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9615:LOC487083
gene id: 9615:LOC487083
uniprot id: A0A8C0MSQ6
uniprot id: E2RR82
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9615:TOMM20
gene id: 9615:TOMM20
uniprot id: A0A8C0MDI3
uniprot id: A0A8I3RSX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:LOC610388
gene id: 9615:LOC610388
uniprot id: A0A8C0PIL2
uniprot id: A0A8I3PU98
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9615:RPS27A
gene id: 9615:RPS27A
uniprot id: A0A8C0T835
uniprot id: A0A8I3NFB9
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

9615:SPP1
gene id: 9615:SPP1
uniprot id: A0A8P0NMW9
uniprot id: A0A8P0NUY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteopontin family.
messages: Secreted

9615:LOC479912
gene id: 9615:LOC479912
uniprot id: A0A8C0NCC1
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9615:PRPF38B
gene id: 9615:PRPF38B
uniprot id: A0A8I3NJZ5
uniprot id: A0A8P0PL45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

9615:LOC116183080
gene id: 9615:LOC116183080
uniprot id: E2R5J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

9615:HYLS1
gene id: 9615:HYLS1
uniprot id: A0A8C0SVU6
uniprot id: A0A8I3RXP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

9615:NOL8
gene id: 9615:NOL8
uniprot id: A0A8C0LUL8
names: Subcellular Location Annotation
messages: nucleolus

9615:PPCS
gene id: 9615:PPCS
uniprot id: A0A8C0S6E6
uniprot id: A0A8I3P9M0
names: Similarity
messages: Belongs to the PPC synthetase family.

9615:NDUFAB1
gene id: 9615:NDUFAB1
uniprot id: A0A8C0Q1C6
uniprot id: A0A8I3MJL3
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9615:LOC611901
gene id: 9615:LOC611901
uniprot id: A0A8I3N7A4
uniprot id: A0A8P0SRD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:HSPA4
gene id: 9615:HSPA4
uniprot id: Q2TFN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9615:WIF1
gene id: 9615:WIF1
uniprot id: A0A8P0PA96
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:SPATA18
gene id: 9615:SPATA18
uniprot id: A0A8C0SK96
uniprot id: A0A8C0YXV2
uniprot id: A0A8I3NHI2
uniprot id: A0A8I3RY91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

9615:ALOX12B
gene id: 9615:ALOX12B
uniprot id: A0A8C0P4Q0
uniprot id: A0A8I3PY71
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:LOC100855676
gene id: 9615:LOC100855676
uniprot id: A0A8I3MAR6
uniprot id: A0A8P0NJV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9615:HAO2
gene id: 9615:HAO2
uniprot id: A0A8C0MFB5
uniprot id: A0A8I3MYD4
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9615:MTF2
gene id: 9615:MTF2
uniprot id: A0A8P0NL59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9615:SAG
gene id: 9615:SAG
uniprot id: Q28281
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arrestin family.
messages: Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.
messages: Defects in SAG may be the cause of generalized progressive retinal atrophy (gPRA) in some breeds.
messages: Membrane
messages: Monomer. Homodimer. Homotetramer. Interacts with RHO (via the phosphorylated C-terminus).
messages: The C-terminus interferes with binding to non-phosphorylated RHO. Interaction with phosphorylated RHO triggers displacement of the C-terminus and leads to a conformation change that mediates high-affinity RHO binding.
messages: photoreceptor outer segment

9615:OR56B2D
gene id: 9615:OR56B2D
uniprot id: A0A8P0NSB7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:LEPROTL1
gene id: 9615:LEPROTL1
uniprot id: A0A8C0Q1W2
uniprot id: A0A8I3NC88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9615:HCN3
gene id: 9615:HCN3
uniprot id: A0A8C0PLK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9615:LGI1
gene id: 9615:LGI1
uniprot id: A0A8C0N6D5
uniprot id: A0A8I3S1M6
names: Subcellular Location Annotation
messages: Secreted

9615:TPH2
gene id: 9615:TPH2
uniprot id: B6EY12
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9615:HEATR1
gene id: 9615:HEATR1
uniprot id: A0A8C0RV46
uniprot id: A0A8I3N2W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9615:MRTO4
gene id: 9615:MRTO4
uniprot id: A0A8C0RFL6
uniprot id: A0A8I3MKC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9615:APOM
gene id: 9615:APOM
uniprot id: A0A8C0MAQ8
uniprot id: A0A8I3NKJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9615:OGN
gene id: 9615:OGN
uniprot id: A0A8P0S8G7
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9615:PRKD3
gene id: 9615:PRKD3
uniprot id: A0A8C0RD54
uniprot id: A0A8I3NYB8
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9615:GJB2
gene id: 9615:GJB2
uniprot id: A0A8C0PAL1
uniprot id: J9NXR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:PHF5A
gene id: 9615:PHF5A
uniprot id: A0A8C0P813
uniprot id: A0A8I3NSG8
names: Similarity
messages: Belongs to the PHF5 family.

9615:TGM2
gene id: 9615:TGM2
uniprot id: A0A8I3PZ15
uniprot id: A0A8P0TKR4
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9615:RNF40
gene id: 9615:RNF40
uniprot id: A0A8C0SFF6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9615:ABCC4
gene id: 9615:ABCC4
uniprot id: A0A8C0SK85
uniprot id: B8K1W7
names: Subcellular Location Annotation
messages: Membrane

9615:TPM3
gene id: 9615:TPM3
uniprot id: A0A8C0Q2Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9615:DLK2
gene id: 9615:DLK2
uniprot id: A0A8C0RI76
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PRKCE
gene id: 9615:PRKCE
uniprot id: A0A8C0MXM3
uniprot id: A0A8C0YQX9
uniprot id: A0A8I3Q258
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

9615:DDI1
gene id: 9615:DDI1
uniprot id: A0A8C0SQA6
names: Similarity
messages: Belongs to the DDI1 family.

9615:C3AR1
gene id: 9615:C3AR1
uniprot id: A0A8C0P7B3
uniprot id: A0A8I3Q2F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9615:PLA2G4B
gene id: 9615:PLA2G4B
uniprot id: A0A8P0SER8
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9615:SLC5A8
gene id: 9615:SLC5A8
uniprot id: A0A8C0YW03
uniprot id: A0A8I3N523
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9615:ACO2
gene id: 9615:ACO2
uniprot id: A0A8C0P9S0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

9615:RNF141
gene id: 9615:RNF141
uniprot id: Q2XNS1
names: Function
names: Subcellular Location Annotation
messages: May be involved in spermatogenesis.
messages: Membrane

9615:NOP14
gene id: 9615:NOP14
uniprot id: A0A8P0NGF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

9615:FAM214B
gene id: 9615:FAM214B
uniprot id: A0A8C0NJE7
uniprot id: A0A8I3N093
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

9615:STX19
gene id: 9615:STX19
uniprot id: A0A8C0T9L9
uniprot id: A0A8I3SCR5
names: Similarity
messages: Belongs to the syntaxin family.

9615:PWWP3B
gene id: 9615:PWWP3B
uniprot id: A0A8I3NV87
uniprot id: A0A8P0PHL5
names: Similarity
messages: Belongs to the PWWP3A family.

9615:API5
gene id: 9615:API5
uniprot id: A0A8C0MAM9
names: Similarity
messages: Belongs to the API5 family.

9615:HTR1E
gene id: 9615:HTR1E
uniprot id: A0A8C0QRS3
uniprot id: A0A8I3RXP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:DARS1
gene id: 9615:DARS1
uniprot id: A0A8C0SMQ2
uniprot id: A0A8I3NDI5
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

9615:CD4
gene id: 9615:CD4
uniprot id: P33705
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in macrophages and a subset of T lymphocytes.
messages: Forms disulfide-linked homodimers at the cell surface. Interacts with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes. Interacts (via Ig-like V-type domain) with MHCII alpha chain (via alpha-2 domain) and beta chain (via beta-2 domain); this interaction increases the affinity of TCR for peptide-MHCII. CD4 oligomerization via Ig-like C2-type 2 and 3 domains appears to be required for stable binding to MHCII and adhesion between T cells and APCs.
messages: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
messages: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
messages: Phosphorylated by PKC; phosphorylation plays an important role for CD4 internalization.
messages: The Ig-like V-type domain mediates the interaction with MHCII.

9615:SPA17
gene id: 9615:SPA17
uniprot id: A0A8C0R964
uniprot id: A0A8I3NGJ9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9615:DGAT2L6
gene id: 9615:DGAT2L6
uniprot id: A0A8C0TKK1
uniprot id: A0A8I3SBZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9615:YPEL5
gene id: 9615:YPEL5
uniprot id: A0A8C0YV52
uniprot id: A0A8I3RYQ6
names: Similarity
messages: Belongs to the yippee family.

9615:H2AC5
gene id: 9615:H2AC5
uniprot id: A0A5F4CIE3
uniprot id: A0A8C0NV55
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:UCN3
gene id: 9615:UCN3
uniprot id: A0A8I3RSJ3
uniprot id: A0A8P0N832
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9615:CAPZB
gene id: 9615:CAPZB
uniprot id: A0A8C0MPT3
uniprot id: A0A8I3MHS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

9615:DOCK10
gene id: 9615:DOCK10
uniprot id: A0A8C0PB77
uniprot id: A0A8C0SZ31
uniprot id: A0A8C0T4D7
uniprot id: A0A8I3NSC8
uniprot id: A0A8I3NVB3
uniprot id: A0A8P0SF57
names: Similarity
messages: Belongs to the DOCK family.

9615:PLET1
gene id: 9615:PLET1
uniprot id: A0A8C0N2W0
uniprot id: A0A8I3MI32
names: Function
messages: Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.

9615:GPAT3
gene id: 9615:GPAT3
uniprot id: A0A8C0N303
uniprot id: A0A8I3PI70
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9615:BLOC1S1
gene id: 9615:BLOC1S1
uniprot id: A0A8I3RU46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S1 family.
messages: Lysosome membrane
messages: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
messages: Mitochondrion intermembrane space

9615:RPL36AL
gene id: 9615:RPL36AL
uniprot id: D0VWQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9615:FGF10
gene id: 9615:FGF10
uniprot id: A0A8C0S4M6
uniprot id: A0A8I3MP09
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:MDH1
gene id: 9615:MDH1
uniprot id: A0A8C0Q1T7
uniprot id: A0A8I3P5G6
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

9615:FZD10
gene id: 9615:FZD10
uniprot id: A0A8C0RP31
uniprot id: A0A8I3SCK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9615:LDLR
gene id: 9615:LDLR
uniprot id: A0A8P0SLN2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:VPS4A
gene id: 9615:VPS4A
uniprot id: A0A8C0S3G1
uniprot id: A0A8I3N2G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9615:PLBD1
gene id: 9615:PLBD1
uniprot id: A0A8P0TJ75
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9615:MSH2
gene id: 9615:MSH2
uniprot id: A0A8C0SBJ9
uniprot id: A0A8I3MVG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

9615:MAEL
gene id: 9615:MAEL
uniprot id: A0A8C0RR38
uniprot id: A0A8I3RRJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9615:MARS2
gene id: 9615:MARS2
uniprot id: A0A8C0TCP3
uniprot id: A0A8I3PY30
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:LOC102155828
gene id: 9615:LOC102155828
uniprot id: A0A8I3P0M0
uniprot id: A0A8P0SXM5
names: Similarity
messages: Belongs to the MS4A family.

9615:RHBDL2
gene id: 9615:RHBDL2
uniprot id: A0A8C0NRL2
uniprot id: A0A8I3QX63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9615:FAM151B
gene id: 9615:FAM151B
uniprot id: A0A8I3RUD7
uniprot id: A0A8P0NB11
names: Similarity
messages: Belongs to the FAM151 family.

9615:GPC4
gene id: 9615:GPC4
uniprot id: A0A8C0TLM2
uniprot id: A0A8I3QZP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9615:XK
gene id: 9615:XK
uniprot id: A0A8C0RGC7
uniprot id: A0A8I3PT94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9615:SLC13A4
gene id: 9615:SLC13A4
uniprot id: A0A8I3N0V1
uniprot id: A0A8P0S941
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9615:ACP5
gene id: 9615:ACP5
uniprot id: A0A8C0SQS6
uniprot id: E2RBY6
names: Cofactor
messages: Binds 2 iron ions per subunit.

9615:CHD9
gene id: 9615:CHD9
uniprot id: A0A8C0MQL1
uniprot id: A0A8C0YVX0
uniprot id: A0A8I3MM51
uniprot id: A0A8I3RSZ4
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9615:RTCB
gene id: 9615:RTCB
uniprot id: A0A8C0RZD5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9615:HCRT
gene id: 9615:HCRT
uniprot id: Q9GLF6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity).
messages: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity).
messages: Cytoplasmic vesicle
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Specific enzymatic cleavages at paired basic residues yield the different active peptides.
messages: Synapse

9615:ITIH2
gene id: 9615:ITIH2
uniprot id: A0A8C0LRI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9615:SPPL3
gene id: 9615:SPPL3
uniprot id: A0A8C0TCU3
uniprot id: A0A8I3Q311
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9615:SEPTIN7
gene id: 9615:SEPTIN7
uniprot id: A0A8I3Q1M0
uniprot id: A0A8P0S903
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium axoneme
messages: flagellum
messages: kinetochore
messages: spindle

9615:DBP
gene id: 9615:DBP
uniprot id: A0A8C0NCM5
uniprot id: A0A8I3MHJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9615:ZNF215
gene id: 9615:ZNF215
uniprot id: A0A8I3NPF2
uniprot id: A0A8P0PG68
names: Subcellular Location Annotation
messages: Nucleus

9615:MRPL24
gene id: 9615:MRPL24
uniprot id: A0A8C0M0D1
uniprot id: A0A8I3MXF1
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9615:ALDH2
gene id: 9615:ALDH2
uniprot id: A0A8I3PA71
uniprot id: A0A8P0PL24
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:GJA5
gene id: 9615:GJA5
uniprot id: A0A654IDC7
uniprot id: P33725
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:GTF2H1
gene id: 9615:GTF2H1
uniprot id: A0A8C0P8L8
uniprot id: A0A8I3NYI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9615:FCRL1
gene id: 9615:FCRL1
uniprot id: A0A8P0SKR2
uniprot id: A0A8P0ST37
names: Subcellular Location Annotation
messages: Cell membrane

9615:TCIRG1
gene id: 9615:TCIRG1
uniprot id: A0A8C0YR98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9615:PCNA
gene id: 9615:PCNA
uniprot id: A0A8C0QFQ6
uniprot id: A0A8I3QKL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9615:COPZ1
gene id: 9615:COPZ1
uniprot id: A0A8C0RTX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9615:OR7A53
gene id: 9615:OR7A53
uniprot id: A0A8C0PNT4
uniprot id: A0A8I3P7U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:NDRG2
gene id: 9615:NDRG2
uniprot id: A0A8C0MIU8
uniprot id: A0A8C0MJZ4
uniprot id: A0A8I3S7Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

9615:KRTAP27-1
gene id: 9615:KRTAP27-1
uniprot id: A0A8I3S2C2
uniprot id: A0A8P0P1D7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9615:CBFA2T2
gene id: 9615:CBFA2T2
uniprot id: A0A8C0Q7S0
names: Similarity
messages: Belongs to the CBFA2T family.

9615:PFDN2
gene id: 9615:PFDN2
uniprot id: A0A8C0NU96
uniprot id: A0A8I3Q7K8
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9615:ELOVL4
gene id: 9615:ELOVL4
uniprot id: A0A8C0Q9N0
uniprot id: A0A8I3NBA5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9615:PGK1
gene id: 9615:PGK1
uniprot id: A0A8C0SZN8
uniprot id: A0A8I3P9Y9
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9615:MRFAP1
gene id: 9615:MRFAP1
uniprot id: A0A8C0M379
uniprot id: A0A8I3N6W7
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9615:HOXA3
gene id: 9615:HOXA3
uniprot id: A0A8C0RDC5
uniprot id: A0A8I3NKF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:CLP1
gene id: 9615:CLP1
uniprot id: A0A8C0SK63
uniprot id: A0A8I3P8U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9615:POLR3B
gene id: 9615:POLR3B
uniprot id: A0A8C0M5D9
uniprot id: A0A8C0RCC3
uniprot id: A0A8I3RXA7
uniprot id: A0A8I3RZT8
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9615:AP2M1
gene id: 9615:AP2M1
uniprot id: A0A8C0N3K7
uniprot id: A0A8I3PSX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9615:HSP90AB1
gene id: 9615:HSP90AB1
uniprot id: A0A8C0MWR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9615:ANAPC10
gene id: 9615:ANAPC10
uniprot id: A0A8C0MQZ1
uniprot id: A0A8I3RWP5
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9615:PLP1
gene id: 9615:PLP1
uniprot id: P23294
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Cell membrane
messages: Defects in PLP1 are the cause of 'shaking pup' disease; a dysmyelinating disease.
messages: Myelin membrane
messages: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

9615:C11H5orf24
gene id: 9615:C11H5orf24
uniprot id: A0A8I3S0C1
uniprot id: A0A8P0TQL8
names: Similarity
messages: Belongs to the UPF0461 family.

9615:IL12B
gene id: 9615:IL12B
uniprot id: Q28268
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Secreted

9615:CNOT6
gene id: 9615:CNOT6
uniprot id: A0A8I3NE67
uniprot id: A0A8P0S6I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9615:MAP2K2
gene id: 9615:MAP2K2
uniprot id: Q1HG70
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).
messages: Cytoplasm
messages: Interacts with MORG1 (By similarity). Interacts with SGK1 (By similarity). Interacts with KSR1. Interacts with KSR1 and BRAF; the interaction with KSR1 mediates KSR1-BRAF dimerization. Interacts with GLS (By similarity).
messages: MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).
messages: Membrane

9615:CES5A
gene id: 9615:CES5A
uniprot id: Q6AW47
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
messages: N-glycosylated.
messages: Secreted

9615:TMEM131L
gene id: 9615:TMEM131L
uniprot id: A0A8C0YW68
uniprot id: A0A8I3N604
names: Similarity
messages: Belongs to the TMEM131 family.

9615:C7
gene id: 9615:C7
uniprot id: A0A8P0T2K7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:PTPN21
gene id: 9615:PTPN21
uniprot id: A0A8C0M4C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9615:RORC
gene id: 9615:RORC
uniprot id: A0A8C0MZK9
uniprot id: A0A8I3PTL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9615:PPP1R2
gene id: 9615:PPP1R2
uniprot id: A0A8C0TYC8
uniprot id: A0A8I3QAG8
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9615:TRIT1
gene id: 9615:TRIT1
uniprot id: A0A8C0SMN1
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

9615:SMC1A
gene id: 9615:SMC1A
uniprot id: A0A8C0N1N1
uniprot id: A0A8C0T3L8
uniprot id: A0A8I3Q022
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9615:CHMP5
gene id: 9615:CHMP5
uniprot id: A0A8C0MIX2
names: Similarity
messages: Belongs to the SNF7 family.

9615:DPPA5
gene id: 9615:DPPA5
uniprot id: A0A8C0NBK0
uniprot id: A0A8I3NLF0
names: Similarity
messages: Belongs to the KHDC1 family.

9615:SEC11A
gene id: 9615:SEC11A
uniprot id: P67811
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:3511473, PubMed:8444896, PubMed:14559916). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SPCS2 and SPCS3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
messages: Endoplasmic reticulum membrane
messages: The C-terminal short (CTS) helix is essential for catalytic activity (By similarity). It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates (By similarity).

9615:SHROOM1
gene id: 9615:SHROOM1
uniprot id: A0A8C0QH78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9615:LOC478184
gene id: 9615:LOC478184
uniprot id: A0A8I3P1I2
uniprot id: A0A8P0NLX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

9615:PHOX2B
gene id: 9615:PHOX2B
uniprot id: A0A8C0MTP5
names: Subcellular Location Annotation
messages: Nucleus

9615:P2RY11
gene id: 9615:P2RY11
uniprot id: A0A8C0TGK0
uniprot id: A0A8I3S0K5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:CACNG2
gene id: 9615:CACNG2
uniprot id: A0A8C0RFF0
uniprot id: A0A8I3MZA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

9615:LTV1
gene id: 9615:LTV1
uniprot id: A0A8C0P365
uniprot id: A0A8I3NIY3
names: Similarity
messages: Belongs to the LTV1 family.

9615:RANBP10
gene id: 9615:RANBP10
uniprot id: A0A8C0P0U7
uniprot id: A0A8I3N3U3
names: Similarity
messages: Belongs to the RANBP9/10 family.

9615:ERBB4
gene id: 9615:ERBB4
uniprot id: A0A8C0NV16
uniprot id: A0A8C0NVA0
uniprot id: A0A8I3S0T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9615:ZUP1
gene id: 9615:ZUP1
uniprot id: A0A8C0PWX2
uniprot id: A0A8I3N0T3
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9615:MTPN
gene id: 9615:MTPN
uniprot id: Q863Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myotrophin family.
messages: Cytoplasm
messages: Interacts with RELA. Interacts with the heterodimer formed by CAPZA1 and CAPZB (By similarity).
messages: Nucleus
messages: Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity).
messages: perinuclear region

9615:ADPRH
gene id: 9615:ADPRH
uniprot id: A0A8I3P1C3
uniprot id: A0A8P0ND15
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9615:TAS2R38
gene id: 9615:TAS2R38
uniprot id: Q2ABD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:ARPC3
gene id: 9615:ARPC3
uniprot id: A0A8C0RRY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9615:CLDN17
gene id: 9615:CLDN17
uniprot id: A0A8C0N8B9
uniprot id: A0A8I3PAG5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:INHA
gene id: 9615:INHA
uniprot id: A0A8C0S5J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9615:STPG1
gene id: 9615:STPG1
uniprot id: A0A8C0PZ34
uniprot id: A0A8I3RY35
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:EIF2A
gene id: 9615:EIF2A
uniprot id: A0A8C0MZQ4
uniprot id: A0A8I3PNA6
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9615:PTPN11
gene id: 9615:PTPN11
uniprot id: A0A4D6PF96
uniprot id: A0A8C0TMQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9615:TMEM106C
gene id: 9615:TMEM106C
uniprot id: A0A8C0PDM8
uniprot id: A0A8I3PIB0
names: Similarity
messages: Belongs to the TMEM106 family.

9615:NMNAT2
gene id: 9615:NMNAT2
uniprot id: A0A8C0PVZ1
uniprot id: A0A8I3MTZ8
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9615:TXNRD2
gene id: 9615:TXNRD2
uniprot id: A0A8P0P0L3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

9615:TOP1
gene id: 9615:TOP1
uniprot id: A0A8C0T9U8
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9615:TIMP4
gene id: 9615:TIMP4
uniprot id: A0A8C0MFN7
uniprot id: E2RPY3
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9615:GPRC5A
gene id: 9615:GPRC5A
uniprot id: A0A8C0RLU4
uniprot id: A0A8I3PWR7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:MRPL17
gene id: 9615:MRPL17
uniprot id: A0A8C0N9W0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9615:CFTR
gene id: 9615:CFTR
uniprot id: Q5U820
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).
messages: N-glycosylated.
messages: Nucleus
messages: Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.
messages: Recycling endosome membrane
messages: The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, NHERF1/EBP50 complex.
messages: The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.
messages: Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity).

9615:H2BC15
gene id: 9615:H2BC15
uniprot id: A0A8C0RQ70
uniprot id: J9P6S8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:COG6
gene id: 9615:COG6
uniprot id: A0A8C0P3P2
uniprot id: A0A8C0QCE0
uniprot id: A0A8I3PHX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

9615:TMEM225
gene id: 9615:TMEM225
uniprot id: A0A8C0LWL5
names: Subcellular Location Annotation
messages: Membrane

9615:SAR1A
gene id: 9615:SAR1A
uniprot id: A0A8C0RJW3
uniprot id: A0A8I3MPA5
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9615:KIF19
gene id: 9615:KIF19
uniprot id: A0A8P0SSG4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:IL1R2
gene id: 9615:IL1R2
uniprot id: A0A8I3N7B1
uniprot id: A0A8P0N589
names: Subcellular Location Annotation
messages: Cell membrane

9615:ELF5
gene id: 9615:ELF5
uniprot id: A0A8C0SUN1
uniprot id: A0A8I3PL55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:NEU3
gene id: 9615:NEU3
uniprot id: A0A8I3MQZ3
uniprot id: A0A8P0N835
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9615:DDX21
gene id: 9615:DDX21
uniprot id: A0A8C0NMM2
uniprot id: A0A8I3RSL8
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9615:H2AC6
gene id: 9615:H2AC6
uniprot id: A0A8C0NTQ3
uniprot id: A0A8I3PW10
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:CD3D
gene id: 9615:CD3D
uniprot id: A0A8C0PNZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:VPS54
gene id: 9615:VPS54
uniprot id: A0A8C0NZZ0
uniprot id: A0A8I3P024
uniprot id: A0A8I3PB93
uniprot id: A0A8P0PIY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS54 family.
messages: trans-Golgi network

9615:MATK
gene id: 9615:MATK
uniprot id: A0A8P0NSA7
uniprot id: A0A8P0T2H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:SGK2
gene id: 9615:SGK2
uniprot id: A0A8C0TPC2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:H1-1
gene id: 9615:H1-1
uniprot id: A0A8I3Q6R5
uniprot id: A0A8P0PNW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9615:GJD2
gene id: 9615:GJD2
uniprot id: A0A8C0PU52
uniprot id: A0A8I3QZQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:GHITM
gene id: 9615:GHITM
uniprot id: A0A8C0M0G3
uniprot id: A0A8I3MY76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9615:RPRD1A
gene id: 9615:RPRD1A
uniprot id: A0A8C0S1C1
uniprot id: A0A8I3N9S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

9615:PHF20
gene id: 9615:PHF20
uniprot id: A0A8C0S5B1
uniprot id: A0A8I3PH12
names: Subcellular Location Annotation
messages: Nucleus

9615:NFE2L2
gene id: 9615:NFE2L2
uniprot id: A0A8P0SQC8
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9615:TOM1L2
gene id: 9615:TOM1L2
uniprot id: A0A8I3PBZ7
uniprot id: A0A8I3PD20
uniprot id: A0A8I3PG25
uniprot id: A0A8P0NJV7
uniprot id: A0A8P0TDE4
uniprot id: A0A8P0THP2
names: Similarity
messages: Belongs to the TOM1 family.

9615:MTO1
gene id: 9615:MTO1
uniprot id: A0A8C0N8J8
uniprot id: A0A8I3NM78
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

9615:GRM7
gene id: 9615:GRM7
uniprot id: A0A8C0MZT0
uniprot id: A0A8I3N699
uniprot id: A0A8I3N6I2
uniprot id: A0A8P0SPL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9615:TIPRL
gene id: 9615:TIPRL
uniprot id: A0A8C0RV66
uniprot id: A0A8I3MP00
names: Similarity
messages: Belongs to the TIP41 family.

9615:PLA2G4A
gene id: 9615:PLA2G4A
uniprot id: A0A8C0LRN9
uniprot id: A0A8C0LS56
uniprot id: A0A8I3MZB9
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

9615:FSHR
gene id: 9615:FSHR
uniprot id: A0A8C0YXW5
uniprot id: A0A8I3N5R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation.
messages: Membrane

9615:LTA
gene id: 9615:LTA
uniprot id: A0A0U5J7M4
uniprot id: Q5WR07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo (By similarity).
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9615:NUF2
gene id: 9615:NUF2
uniprot id: A0A8C0S2W9
uniprot id: A0A8I3S9L8
names: Similarity
messages: Belongs to the NUF2 family.

9615:MAPK13
gene id: 9615:MAPK13
uniprot id: A0A8C0T102
uniprot id: A0A8I3NKJ3
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

9615:SSR4
gene id: 9615:SSR4
uniprot id: A0A8C0NNM2
uniprot id: A0A8I3PXW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9615:LOC610636
gene id: 9615:LOC610636
uniprot id: A0A8C0TTK7
uniprot id: A0A8I3SCG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:RDH14
gene id: 9615:RDH14
uniprot id: A0A8C0SE66
uniprot id: A0A8I3RZT7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:FLAD1
gene id: 9615:FLAD1
uniprot id: A0A8C0PMT6
uniprot id: A0A8I3P1H5
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9615:PCOLCE
gene id: 9615:PCOLCE
uniprot id: A0A8C0SJ81
uniprot id: A0A8I3MHG0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:DOK4
gene id: 9615:DOK4
uniprot id: A0A8C0M0V8
uniprot id: A0A8I3ML20
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9615:CEMIP2
gene id: 9615:CEMIP2
uniprot id: A0A8I3RQN5
uniprot id: A0A8P0N4X8
names: Similarity
messages: Belongs to the CEMIP family.

9615:NPRL2
gene id: 9615:NPRL2
uniprot id: A0A8C0N1K0
uniprot id: A0A8C0NAB9
uniprot id: A0A8I3P781
uniprot id: A0A8I3PM87
names: Similarity
messages: Belongs to the NPR2 family.

9615:TBX15
gene id: 9615:TBX15
uniprot id: A0A8C0SKN9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:CSE1L
gene id: 9615:CSE1L
uniprot id: A0A8C0S3Y6
uniprot id: A0A8I3PFQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9615:TAF15
gene id: 9615:TAF15
uniprot id: A0A8C0RXV8
uniprot id: A0A8I3RWN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9615:STOML2
gene id: 9615:STOML2
uniprot id: A0A8C0NHE2
uniprot id: A0A8I3N1K9
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9615:RPN2
gene id: 9615:RPN2
uniprot id: A0A8P0NYL0
uniprot id: F1PCT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:12887896, PubMed:15835887, PubMed:25135935). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:15835887, PubMed:29519914). Interacts with DDI2 (By similarity). Interacts with TMEM35A/NACHO (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9615:STRADB
gene id: 9615:STRADB
uniprot id: A0A8C0TFS3
uniprot id: A0A8I3SCL1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9615:SLC30A6
gene id: 9615:SLC30A6
uniprot id: A0A8C0SIR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9615:EMC3
gene id: 9615:EMC3
uniprot id: A0A8C0RDQ2
uniprot id: A0A8I3MZ54
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9615:MRPL16
gene id: 9615:MRPL16
uniprot id: A0A8C0PZ41
uniprot id: A0A8I3PA59
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9615:CCT8L2
gene id: 9615:CCT8L2
uniprot id: A0A8C0S1S6
uniprot id: A0A8I3NA78
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

9615:NME6
gene id: 9615:NME6
uniprot id: A0A8I3N546
uniprot id: A0A8P0SSD0
names: Similarity
messages: Belongs to the NDK family.

9615:ABCG8
gene id: 9615:ABCG8
uniprot id: A0A8C0N9U1
uniprot id: A0A8I3PWN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9615:PPP1R2C
gene id: 9615:PPP1R2C
uniprot id: A0A8C0SKI3
uniprot id: A0A8I3Q1F6
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9615:CLCN3
gene id: 9615:CLCN3
uniprot id: A0A8C0NYF0
uniprot id: A0A8C0RPW3
uniprot id: Q4LAL7
uniprot id: Q4LAL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9615:TES
gene id: 9615:TES
uniprot id: A0M8U6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
messages: focal adhesion

9615:AMOTL1
gene id: 9615:AMOTL1
uniprot id: A0A8C0NNX4
uniprot id: A0A8C0NVM4
uniprot id: A0A8C0P0E4
uniprot id: A0A8I3PFB7
names: Similarity
messages: Belongs to the angiomotin family.

9615:SH3BGRL
gene id: 9615:SH3BGRL
uniprot id: A0A8C0T5H5
uniprot id: A0A8I3PBA6
names: Similarity
messages: Belongs to the SH3BGR family.

9615:TEKT3
gene id: 9615:TEKT3
uniprot id: A0A8C0PPL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9615:SF3A3
gene id: 9615:SF3A3
uniprot id: A0A8C0NLV9
uniprot id: E2QXU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3A3 family.
messages: Nucleus

9615:MTMR4
gene id: 9615:MTMR4
uniprot id: A0A8C0MQ27
uniprot id: A0A8C0PTK9
uniprot id: A0A8I3PDB6
uniprot id: A0A8I3S4N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9615:DAZAP2
gene id: 9615:DAZAP2
uniprot id: A0A8C0PBN1
uniprot id: A0A8I3P0Q8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

9615:HIBCH
gene id: 9615:HIBCH
uniprot id: A0A8C0RLB1
uniprot id: A0A8I3S4X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

9615:DUS3L
gene id: 9615:DUS3L
uniprot id: A0A8C0P647
uniprot id: A0A8I3NLU0
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

9615:SLC22A8
gene id: 9615:SLC22A8
uniprot id: A0A8C0SXT3
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9615:ALG11
gene id: 9615:ALG11
uniprot id: A0A8C0QG63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

9615:MAGT1
gene id: 9615:MAGT1
uniprot id: A0A8C0SXS8
uniprot id: A0A8I3PBS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:FGD6
gene id: 9615:FGD6
uniprot id: A0A8C0QFB6
uniprot id: A0A8I3PLR1
names: Subcellular Location Annotation
messages: cytoskeleton

9615:LOC102155749
gene id: 9615:LOC102155749
uniprot id: A0A8C0QBD6
uniprot id: A0A8I3NZS9
names: Similarity
messages: Belongs to the MS4A family.

9615:PRKAB1
gene id: 9615:PRKAB1
uniprot id: A0A8C0Z144
uniprot id: A0A8I3PY75
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9615:TBX20
gene id: 9615:TBX20
uniprot id: A0A8C0NFR0
uniprot id: A0A8I3Q4U5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:INPP5A
gene id: 9615:INPP5A
uniprot id: Q29467
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.
messages: Cell membrane
messages: Inhibited by EDTA and 2,3-bisphosphoglycerate.
messages: Interacts with TASOR.
messages: Isoprenylation at Cys-409 is required for localization at the membrane.
messages: Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8198557). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity).
messages: dendrite

9615:PTGS2
gene id: 9615:PTGS2
uniprot id: A0A8P0NFH5
uniprot id: Q8SPQ9
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:HLF
gene id: 9615:HLF
uniprot id: A0A8C0N6X2
uniprot id: A0A8I3NX86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9615:GABRA3
gene id: 9615:GABRA3
uniprot id: A0A8C0SP42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:LOC609612
gene id: 9615:LOC609612
uniprot id: A0A8C0Z2T7
uniprot id: A0A8I3N9V0
names: Similarity
messages: Belongs to the folate receptor family.

9615:RAB11A
gene id: 9615:RAB11A
uniprot id: P62490
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Endosome membrane
messages: Golgi apparatus
messages: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4 (By similarity). Forms a complex with RAB11FIP3 and dynein intermediate chain DYNC1LI1; the interaction between RAB11A1 and RAB11FIP3 is direct; the complex regulates endocytic trafficking (By similarity). Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A (By similarity). Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39 (By similarity). Interacts with EXOC6 in a GTP-dependent manner. Interacts with RAB11FIP5. Interacts with STXBP6. Interacts (GDP-bound form) with ZFYVE27 (By similarity). Interacts with BIRC6/bruce (By similarity). May interact with TBC1D14 (By similarity). Interacts with UNC119; in a cell cycle-dependent manner (By similarity). GDP-bound and nucleotide-free forms interact with SH3BP5 (By similarity). Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts (GDP-bound form) with RELCH (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity). Interacts with TBC1D12 (By similarity). Interacts with DEF6 (By similarity). Interacts with ATP9A (By similarity). Forms a heterotetramer with RAB11FIP3; the GTP-bound form is preferred for binding. Forms a complex with Rabin8/RAB3IP and RAB11FIP3, probably a heterohexamer with two of each protein subunit, where Rabin8/RAB3IP and RAB11FIP3 simultaneously bind to RAB11A; the complex promotes preciliary trafficking and cilia growth. Forms a complex containing RAB11A, ASAP1, Rabin8/RAB3IP, RAP11FIP3 and ARF4; the complex promotes preciliary trafficking; the complex binds to RHO in photoreceptor cells and promotes RHO ciliary transport. Interacts (GTP-bound form) with WDR44; the interaction prevents RAB11A-RAB3IP-RAB11FIP3 complex formation (By similarity).
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). The small Rab GTPase RAB11A regulates endocytic recycling (By similarity). Forms a functional Rab11/FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (By similarity). Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (PubMed:19451275). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation. On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FI…
messages: phagosome
messages: trans-Golgi network

9615:SERINC3
gene id: 9615:SERINC3
uniprot id: A0A8C0TP27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9615:CENPO
gene id: 9615:CENPO
uniprot id: A0A8C0P595
uniprot id: A0A8I3PSY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

9615:HMGN1
gene id: 9615:HMGN1
uniprot id: A0A8C0RRP0
uniprot id: A0A8I3Q3N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9615:DSC2
gene id: 9615:DSC2
uniprot id: A0A8C0LTT0
uniprot id: A0A8I3NHU5
uniprot id: A0A8P0SV43
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9615:TEAD1
gene id: 9615:TEAD1
uniprot id: A0A8I3S448
uniprot id: A0A8P0T894
names: Subcellular Location Annotation
messages: Nucleus

9615:TNNT3
gene id: 9615:TNNT3
uniprot id: A0A8C0TTU2
uniprot id: A0A8C0Z6D9
uniprot id: A0A8I3N599
uniprot id: A0A8I3N9X8
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9615:RRM1
gene id: 9615:RRM1
uniprot id: A0A8C0RNZ0
uniprot id: A0A8I3RYN5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9615:RAD54L2
gene id: 9615:RAD54L2
uniprot id: A0A8C0SKY0
uniprot id: A0A8I3P7Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9615:EXOC7
gene id: 9615:EXOC7
uniprot id: A0A8C0LZG6
uniprot id: A0A8C0R9Z2
uniprot id: A0A8C0RA01
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9615:DPM1
gene id: 9615:DPM1
uniprot id: A0A8I3PV83
uniprot id: A0A8P0STA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9615:MZT1
gene id: 9615:MZT1
uniprot id: A0A8C0RHU5
uniprot id: A0A8I3S595
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9615:INPP1
gene id: 9615:INPP1
uniprot id: A0A8C0SLR9
uniprot id: A0A8I3PT90
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9615:CLDN18
gene id: 9615:CLDN18
uniprot id: A0A8C0N3B4
uniprot id: A0A8C0TMZ8
uniprot id: A0A8I3PMY9
uniprot id: A0A8I3PV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9615:FARSA
gene id: 9615:FARSA
uniprot id: A0A8C0P139
uniprot id: A0A8I3NX27
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

9615:DCTPP1
gene id: 9615:DCTPP1
uniprot id: A0A8C0M3Y7
uniprot id: A0A8I3P1M0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9615:VPS37A
gene id: 9615:VPS37A
uniprot id: A0A8C0P2Z0
uniprot id: A0A8I3RY92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9615:SLC25A39
gene id: 9615:SLC25A39
uniprot id: A0A8C0YZ48
uniprot id: A0A8I3RW24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9615:PHF1
gene id: 9615:PHF1
uniprot id: A0A8C0N5P1
uniprot id: A0A8I3PPA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9615:MAT2B
gene id: 9615:MAT2B
uniprot id: A0A8C0NUP6
uniprot id: A0A8C0PUB6
uniprot id: A0A8I3MF25
uniprot id: A0A8I3RP35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9615:MACIR
gene id: 9615:MACIR
uniprot id: A0A8I3MX78
uniprot id: A0A8P0PSI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9615:THY1
gene id: 9615:THY1
uniprot id: A0A8C0Z1H7
uniprot id: A0A8I3NQP0
names: Subcellular Location Annotation
messages: Cell membrane

9615:FUT9
gene id: 9615:FUT9
uniprot id: Q659L1
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by Mn2+.
messages: Belongs to the glycosyltransferase 10 family.
messages: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth. Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lactosamine unit of the alpha2,3-sialylated polylactosamine resulting in sLex (CD15s) epitope synthesis. Furthermore, it is capable to synthesizes Lewis a (Lea), although to a lesser extent than Lex and Lewis y (Ley) and to confer SELE-dependent, but not SELL- and SELP-selectin-dependent, cell rolling and adhesion by enhancing Lex and sLex synthesis. May also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE.
messages: Golgi apparatus membrane
messages: N-glycosylated with complex-type N-glycans.
messages: trans-Golgi network membrane

9615:IRF2BP1
gene id: 9615:IRF2BP1
uniprot id: A0A8C0QH95
uniprot id: A0A8I3MX52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9615:B3GALT5
gene id: 9615:B3GALT5
uniprot id: A0A8I3Q8H7
uniprot id: A0A8P0TPI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:MRPS31
gene id: 9615:MRPS31
uniprot id: A0A8C0NTF3
uniprot id: A0A8I3S469
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

9615:NPY1R
gene id: 9615:NPY1R
uniprot id: O02813
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for neuropeptide Y and peptide YY.

9615:CLCN7
gene id: 9615:CLCN7
uniprot id: A0A8P0P8M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9615:XPO5
gene id: 9615:XPO5
uniprot id: A0A8C0N5B7
uniprot id: A0A8C0QGU2
uniprot id: A0A8I3RXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9615:HOXA5
gene id: 9615:HOXA5
uniprot id: A0A8C0MH05
uniprot id: A0A8I3N8Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:TBP
gene id: 9615:TBP
uniprot id: A0A8C0N7G7
uniprot id: A0A8I3PUG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9615:CAPS
gene id: 9615:CAPS
uniprot id: P10463
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Calcium-binding protein. May play a role in cellular signaling events (Potential).
messages: Cytoplasm
messages: Detected in thyroid, salivary gland, lung, brain and cerebellum (at protein level).
messages: Monomer. Does not form oligomers in the presence of calcium (By similarity).
messages: Phosphorylated in response to thyrotropin and cAMP.

9615:CRYAB
gene id: 9615:CRYAB
uniprot id: A0A8C0Q8G4
uniprot id: A0A8I3MR05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9615:YIPF7
gene id: 9615:YIPF7
uniprot id: A0A8C0TR10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9615:BANP
gene id: 9615:BANP
uniprot id: A0A8C0NPT8
uniprot id: A0A8C0NRV1
uniprot id: A0A8I3ML24
uniprot id: A0A8I3N6J3
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9615:STOM
gene id: 9615:STOM
uniprot id: A0A8C0NIZ2
uniprot id: B6F250
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9615:AK8
gene id: 9615:AK8
uniprot id: A0A8C0P0G9
uniprot id: A0A8I3NQB2
names: Similarity
messages: Belongs to the adenylate kinase family.

9615:KCNK2
gene id: 9615:KCNK2
uniprot id: A0A8C0MBK2
uniprot id: A0A8C0PVA0
uniprot id: A0A8C0Q4T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9615:KIF4A
gene id: 9615:KIF4A
uniprot id: A0A8C0THV7
uniprot id: A0A8I3Q5Y5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:RAB3C
gene id: 9615:RAB3C
uniprot id: A0A8C0PTV6
uniprot id: A0A8C0R9H4
uniprot id: A0A8I3RTL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9615:ADCY6
gene id: 9615:ADCY6
uniprot id: A0A8C0P6Z2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9615:NSUN6
gene id: 9615:NSUN6
uniprot id: A0A8C0MXM1
uniprot id: A0A8I3NEZ3
uniprot id: A0A8I3RXD1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:NANOS2
gene id: 9615:NANOS2
uniprot id: A0A8C0QJZ7
uniprot id: A0A8I3MLE5
names: Similarity
messages: Belongs to the nanos family.

9615:CYP19A1
gene id: 9615:CYP19A1
uniprot id: Q5QQX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:HSF5
gene id: 9615:HSF5
uniprot id: A0A8C0RUH4
uniprot id: A0A8I3P557
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9615:CFL2
gene id: 9615:CFL2
uniprot id: A0A8C0MJA4
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9615:ZER1
gene id: 9615:ZER1
uniprot id: A0A8C0MBW2
names: Similarity
messages: Belongs to the zyg-11 family.

9615:GNG3
gene id: 9615:GNG3
uniprot id: A0A8C0RDX7
uniprot id: A0A8I3MYE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:DDOST
gene id: 9615:DDOST
uniprot id: Q05052
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:12887896, PubMed:15835887, PubMed:25135935). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:15835887, PubMed:29519914). Interacts with SMIM22 (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: It is uncertain whether Met-1 or Met-7 is the initiator.
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:12887896). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).

9615:IGF2R
gene id: 9615:IGF2R
uniprot id: A0A8P0NNR9
uniprot id: B1H0W0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PPP1R35
gene id: 9615:PPP1R35
uniprot id: A0A8C0NWP5
uniprot id: A0A8I3MLR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP1R35 family.
messages: centriole

9615:ILDR1
gene id: 9615:ILDR1
uniprot id: A0A8P0SRQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9615:LYRM1
gene id: 9615:LYRM1
uniprot id: A0A8C0LSN3
names: Similarity
messages: Belongs to the complex I LYR family.

9615:CCL7
gene id: 9615:CCL7
uniprot id: Q5KSU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9615:UBXN1
gene id: 9615:UBXN1
uniprot id: A0A8C0T2W0
uniprot id: A0A8I3N9J6
names: Subcellular Location Annotation
messages: Cytoplasm

9615:VPS18
gene id: 9615:VPS18
uniprot id: A0A8C0P7C4
uniprot id: A0A8I3Q5H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9615:SMU1
gene id: 9615:SMU1
uniprot id: A0A8P0NSV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9615:FAM32A
gene id: 9615:FAM32A
uniprot id: A0A8C0RR58
uniprot id: A0A8I3QXR1
names: Similarity
messages: Belongs to the FAM32 family.

9615:LRWD1
gene id: 9615:LRWD1
uniprot id: A0A8P0SII1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRWD1 family.
messages: centrosome
messages: kinetochore
messages: telomere

9615:ZNF280C
gene id: 9615:ZNF280C
uniprot id: A0A8C0TD36
uniprot id: A0A8I3Q8G8
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9615:BCS1L
gene id: 9615:BCS1L
uniprot id: A0A8C0MGE4
uniprot id: A0A8I3Q294
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9615:CRYGD
gene id: 9615:CRYGD
uniprot id: A9JPX7
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9615:PLIN1
gene id: 9615:PLIN1
uniprot id: A0A8I3RQT5
uniprot id: A0A8P0SGU4
names: Similarity
messages: Belongs to the perilipin family.

9615:CRSP-2
gene id: 9615:CRSP-2
uniprot id: Q75V93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted

9615:LPAR4
gene id: 9615:LPAR4
uniprot id: A0A8C0MYB2
uniprot id: A0A8I3PJM2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:LOC609445
gene id: 9615:LOC609445
uniprot id: A0A8C0TQ36
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:MFSD1
gene id: 9615:MFSD1
uniprot id: A0A8C0NSE6
uniprot id: A0A8I3PRU1
names: Subcellular Location Annotation
messages: Membrane

9615:MAP2K3
gene id: 9615:MAP2K3
uniprot id: A0A8C0RB66
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:SMAD1
gene id: 9615:SMAD1
uniprot id: A0A8C0MGA9
uniprot id: A0A8I3NM89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9615:G6PC3
gene id: 9615:G6PC3
uniprot id: A0A8C0T0Z4
uniprot id: A0A8I3ND17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9615:SGCE
gene id: 9615:SGCE
uniprot id: A0A8C0NMV4
uniprot id: A0A8C0NPB9
uniprot id: A0A8C0SFE6
uniprot id: A0A8I3P8I1
uniprot id: A0A8I3PFQ5
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

9615:C20H19orf25
gene id: 9615:C20H19orf25
uniprot id: A0A8C0N795
uniprot id: A0A8I3NN05
names: Similarity
messages: Belongs to the UPF0449 family.

9615:RPS29
gene id: 9615:RPS29
uniprot id: A0A8C0LXK4
uniprot id: A0A8I3RQJ0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9615:NNMT
gene id: 9615:NNMT
uniprot id: A0A8C0RF84
uniprot id: A0A8I3MY20
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9615:MYB
gene id: 9615:MYB
uniprot id: A0A8C0M930
uniprot id: A0A8C0MAR7
uniprot id: A0A8C0RV16
uniprot id: A0A8I3MZK9
names: Subcellular Location Annotation
messages: Nucleus

9615:AGAP1
gene id: 9615:AGAP1
uniprot id: A0A8C0P9T2
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9615:FAT2
gene id: 9615:FAT2
uniprot id: A0A8C0QBQ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:LTB
gene id: 9615:LTB
uniprot id: A0A8P0SU14
uniprot id: J9P2Z1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9615:AHR
gene id: 9615:AHR
uniprot id: A0A8I3RSX6
uniprot id: A0A8P0P205
names: Subcellular Location Annotation
messages: Cytoplasm

9615:GATAD2A
gene id: 9615:GATAD2A
uniprot id: A0A8C0N2C4
names: Subcellular Location Annotation
messages: Nucleus

9615:MACF1
gene id: 9615:MACF1
uniprot id: A0A8C0P0L7
names: Subcellular Location Annotation
messages: cytoskeleton

9615:SCN1A
gene id: 9615:SCN1A
uniprot id: A0A8P0SG87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9615:REEP4
gene id: 9615:REEP4
uniprot id: A0A8C0NMU1
uniprot id: A0A8I3PSS0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:OXSM
gene id: 9615:OXSM
uniprot id: A0A8I3PPX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9615:PAMR1
gene id: 9615:PAMR1
uniprot id: A0A8C0PE44
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:LOC100685213
gene id: 9615:LOC100685213
uniprot id: P81255
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
messages: Secreted

9615:SMIM18
gene id: 9615:SMIM18
uniprot id: A0A8C0ST36
uniprot id: A0A8I3NVX5
names: Subcellular Location Annotation
messages: Membrane

9615:THBS3
gene id: 9615:THBS3
uniprot id: A0A8C0PG23
uniprot id: A0A8I3NMW4
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SLC9A1
gene id: 9615:SLC9A1
uniprot id: A0A8C0N5D8
uniprot id: A0A8I3RW87
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9615:GPR34
gene id: 9615:GPR34
uniprot id: A0A8P0PQD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor.

9615:MCM8
gene id: 9615:MCM8
uniprot id: A0A8C0QE82
uniprot id: A0A8I3SAV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9615:ARHGEF2
gene id: 9615:ARHGEF2
uniprot id: Q865S3
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Involved in neuronal progenitor cell division and differentiation. Involved in the migration of precerebellar neurons (By similarity). Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (PubMed:12604587).
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Interacts with YWHAZ/14-3-3 zeta; when phosphorylated at Ser-886. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts with RHOA and RAC1. Interacts with NOD1. Interacts (via the N- terminal zinc finger) with CAPN6 (via domain II). Found in a complex composed at least of ARHGEF2, NOD2 and RIPK2. Interacts with RIPK2; the interaction mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. Interacts with RIPK1 and RIPK3 (By similarity). Interacts with DYNLT1.
messages: Phosphorylation of Ser-886 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4 releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a RIPK2-dependent manner (By similarity).
messages: The DH (DBL-homology) domain promotes tyrosine phosphorylation of RIPK2 (By similarity). The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA.
messages: The PH domain has no affinity for phosphoinositides suggesting that it does not interact directly with membranes.
messages: The phorbol-ester/DAG-type zinc-finger and the C-terminal coiled-coil domains (606-986) are both important for association with microtubules.
messages: cytoskeleton
messages: spindle
messages: tight junction

9615:HSD3B2
gene id: 9615:HSD3B2
uniprot id: Q5IFP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids (By similarity).
messages: Belongs to the 3-beta-HSD family.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane

9615:CHRDL2
gene id: 9615:CHRDL2
uniprot id: A0A8C0NL98
uniprot id: A0A8I3RT64
names: Subcellular Location Annotation
messages: Secreted

9615:DCP1A
gene id: 9615:DCP1A
uniprot id: A0A8C0PRZ9
uniprot id: A0A8P0T0S1
names: Similarity
messages: Belongs to the DCP1 family.

9615:HOXD10
gene id: 9615:HOXD10
uniprot id: A0A8C0SWX2
uniprot id: A0A8I3P3F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9615:DIS3L2
gene id: 9615:DIS3L2
uniprot id: A0A8I3PTC4
uniprot id: A0A8P0SFY0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cytoplasm
messages: P-body
messages: Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.

9615:PRLHR
gene id: 9615:PRLHR
uniprot id: A0A8C0PH07
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:FZD6
gene id: 9615:FZD6
uniprot id: Q8WMU5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Interacts with LMBR1L.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Membrane
messages: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).
messages: The FZ domain is involved in binding with Wnt ligands.
messages: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

9615:BANF2
gene id: 9615:BANF2
uniprot id: A0A8C0Z6K1
uniprot id: A0A8I3P4W0
names: Subcellular Location Annotation
messages: Nucleus

9615:MRRF
gene id: 9615:MRRF
uniprot id: A0A8I3RXP7
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9615:EIF3K
gene id: 9615:EIF3K
uniprot id: A0A8C0RKG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9615:LOC486151
gene id: 9615:LOC486151
uniprot id: A0A8C0RS14
uniprot id: A0A8I3S2D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

9615:CCDC66
gene id: 9615:CCDC66
uniprot id: F1PZQ5
names: Disease Annotation
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Defects in CCDC66 are the cause of generalized progressive retinal atrophy (gPRA), characterized by continuous degeneration of photoreceptor cells leading to night blindness and progressive vision loss. A homozygous mutation in the CCDC66 gene resulting in a frameshift and the production of a truncated protein is probably causing the disease.
messages: Expressed in retina and blood (PubMed:19777273). Expressed in retina, mainly in photoreceptors but also in outer plexiform and ganglion cell layers (at protein level) (PubMed:19777273).
messages: Homodimer; disulfide-linked (By similarity). Interacts with CEP290 (By similarity). Interacts with PCM1 (By similarity). Interacts with ARMC9, TOGARAM1, CSPP1 and CEP104 (By similarity).
messages: Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (By similarity). Plays a role in retina morphogenesis and/or homeostasis (PubMed:19777273).
messages: Photoreceptor inner segment
messages: centriolar satellite
messages: centrosome
messages: cilium
messages: cilium basal body
messages: photoreceptor outer segment

9615:TEF
gene id: 9615:TEF
uniprot id: A0A8C0Z0U2
uniprot id: A0A8I3NXC1
uniprot id: A0A8I3P486
uniprot id: A0A8P0TMZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9615:NRF1
gene id: 9615:NRF1
uniprot id: A0A8C0S352
uniprot id: A0A8I3PAK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

9615:PLAU
gene id: 9615:PLAU
uniprot id: A0A8C0RW08
uniprot id: A0A8I3NA75
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:YARS2
gene id: 9615:YARS2
uniprot id: A0A8C0PGU0
uniprot id: A0A8I3NPB7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:MOCS2
gene id: 9615:MOCS2
uniprot id: A0A8C0QI15
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9615:STAC
gene id: 9615:STAC
uniprot id: A0A8C0MDG5
uniprot id: A0A8C0SIE4
uniprot id: A0A8I3PLW3
names: Subcellular Location Annotation
messages: sarcolemma

9615:EXT1
gene id: 9615:EXT1
uniprot id: A0A8C0SS15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:EPB41L5
gene id: 9615:EPB41L5
uniprot id: Q9MYU8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Component of a complex composed of PALS1, CRB1 and EPB41L5 (By similarity). Within the complex, interacts (via FERM domain) with PALS1 (via HOOK domain) and with CRB1 (via intracellular domain) (By similarity). Interacts with CRB2 (via intracellular domain) (By similarity). Interacts with CRB3 (via intracellular domain) (By similarity).
messages: Cytoplasm
messages: Photoreceptor inner segment
messages: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.
messages: adherens junction

9615:SETDB1
gene id: 9615:SETDB1
uniprot id: A0A8C0SCA0
uniprot id: A0A8I3PJ60
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9615:YY1
gene id: 9615:YY1
uniprot id: A0A8C0Q4Q1
uniprot id: A0A8I3MKF1
names: Similarity
messages: Belongs to the YY transcription factor family.

9615:GABRG3
gene id: 9615:GABRG3
uniprot id: A0A8C0Q305
uniprot id: A0A8I3P8N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:BECN1
gene id: 9615:BECN1
uniprot id: A0A8C0RAA1
uniprot id: A0A8C0TAY3
uniprot id: A0A8I3MVR6
uniprot id: A0A8I3N683
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9615:NLRP12
gene id: 9615:NLRP12
uniprot id: A0A8C0RUY7
uniprot id: A0A8I3N819
uniprot id: A0A8P0S8J8
names: Similarity
messages: Belongs to the NLRP family.

9615:JUNB
gene id: 9615:JUNB
uniprot id: A0A8C0NSJ2
uniprot id: A0A8I3RZ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9615:RARRES2
gene id: 9615:RARRES2
uniprot id: A0A8C0PHW2
names: Subcellular Location Annotation
messages: Secreted

9615:NXF3
gene id: 9615:NXF3
uniprot id: A0A8C0MN57
uniprot id: A0A8I3PQX6
names: Subcellular Location Annotation
messages: Cytoplasm

9615:SLC2A10
gene id: 9615:SLC2A10
uniprot id: A0A8C0NW43
uniprot id: A0A8I3NZW4
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9615:BEX4
gene id: 9615:BEX4
uniprot id: A0A8C0REE8
names: Similarity
messages: Belongs to the BEX family.

9615:CABIN1
gene id: 9615:CABIN1
uniprot id: A0A8P0NNM3
names: Subcellular Location Annotation
messages: Nucleus

9615:OR11G2B
gene id: 9615:OR11G2B
uniprot id: G3FJB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:DHRS7C
gene id: 9615:DHRS7C
uniprot id: A0A8C0SN15
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:SLC22A10
gene id: 9615:SLC22A10
uniprot id: A0A8C0MPT8
names: Subcellular Location Annotation
messages: Membrane

9615:TLR9
gene id: 9615:TLR9
uniprot id: Q865B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
messages: Lysosome
messages: Membrane
messages: phagosome

9615:INS
gene id: 9615:INS
uniprot id: P01321
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

9615:HOXA13
gene id: 9615:HOXA13
uniprot id: A0A8C0MBE8
uniprot id: A0A8I3NNY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9615:SARAF
gene id: 9615:SARAF
uniprot id: A0A8P0TT03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9615:LOC606863
gene id: 9615:LOC606863
uniprot id: A0A8C0QBH6
uniprot id: C3UZV0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9615:LANCL1
gene id: 9615:LANCL1
uniprot id: A0A8C0SMD9
uniprot id: A0A8I3P5K2
names: Similarity
messages: Belongs to the LanC-like protein family.

9615:NKX2-6
gene id: 9615:NKX2-6
uniprot id: A0A8C0TEV1
uniprot id: A0A8I3NYD2
names: Subcellular Location Annotation
messages: Nucleus

9615:IFI35
gene id: 9615:IFI35
uniprot id: A0A8C0RAJ1
uniprot id: A0A8I3RT92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9615:B3GNT2
gene id: 9615:B3GNT2
uniprot id: A0A8C0QFX8
uniprot id: A0A8I3NVQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:SMC3
gene id: 9615:SMC3
uniprot id: A0A8C0T4U5
uniprot id: A0A8I3PXW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

9615:H2BC8
gene id: 9615:H2BC8
uniprot id: A0A8C0P6N2
uniprot id: H9GWB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:RIOK1
gene id: 9615:RIOK1
uniprot id: A0A8C0N685
uniprot id: A0A8I3NZ39
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9615:SPTLC2
gene id: 9615:SPTLC2
uniprot id: A0A8C0T254
uniprot id: A0A8I3N8H8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9615:UBE2A
gene id: 9615:UBE2A
uniprot id: A0A8C0NI27
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:SLC35B1
gene id: 9615:SLC35B1
uniprot id: A0A8C0LY15
uniprot id: A0A8I3NIE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9615:LIAS
gene id: 9615:LIAS
uniprot id: A0A8P0SK96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9615:PPBP
gene id: 9615:PPBP
uniprot id: A0A8C0RPL3
uniprot id: A0A8I3NDZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9615:LOC100855600
gene id: 9615:LOC100855600
uniprot id: A0A5F4CYE6
uniprot id: A0A8C0MTB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9615:NAA10
gene id: 9615:NAA10
uniprot id: A0A8I3PUM4
uniprot id: A0A8P0TS28
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9615:RRM2
gene id: 9615:RRM2
uniprot id: A0A8C0RDC7
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9615:FCN2
gene id: 9615:FCN2
uniprot id: A0A8C0PRX5
uniprot id: A0A8I3NLF4
names: Similarity
messages: Belongs to the ficolin lectin family.

9615:SCAND1
gene id: 9615:SCAND1
uniprot id: A0A8C0S5U0
uniprot id: A0A8I3PLZ2
names: Subcellular Location Annotation
messages: Nucleus

9615:ING1
gene id: 9615:ING1
uniprot id: A0A8C0PI87
uniprot id: A0A8I3PA68
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9615:HOXC13
gene id: 9615:HOXC13
uniprot id: A0A8I3NWE9
uniprot id: A0A8P0SC12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9615:FAM83G
gene id: 9615:FAM83G
uniprot id: A0A8I3P584
uniprot id: A0A8P0N820
names: Similarity
messages: Belongs to the FAM83 family.

9615:FAM76A
gene id: 9615:FAM76A
uniprot id: A0A8C0Q2Q9
uniprot id: A0A8I3NJ36
names: Similarity
messages: Belongs to the FAM76 family.

9615:SLC29A2
gene id: 9615:SLC29A2
uniprot id: A0A8C0NPU9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

9615:HBE1
gene id: 9615:HBE1
uniprot id: A0A1K0GY94
names: Similarity
messages: Belongs to the globin family.

9615:LIPJ
gene id: 9615:LIPJ
uniprot id: A0A8C0P5T9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9615:ATP9B
gene id: 9615:ATP9B
uniprot id: A0A8C0M7J8
uniprot id: A0A8C0PW33
uniprot id: A0A8C0Q0F3
uniprot id: A0A8I3MA25
uniprot id: A0A8I3MEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:LOC100856086
gene id: 9615:LOC100856086
uniprot id: A0A8P0TRH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tigger transposable element derived protein family.
messages: Nucleus

9615:CLSPN
gene id: 9615:CLSPN
uniprot id: A0A8I3NR70
uniprot id: A0A8P0N6E4
names: Subcellular Location Annotation
messages: Nucleus

9615:H4-16
gene id: 9615:H4-16
uniprot id: A0A8C0TQ44
uniprot id: F2Z4N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:TIGD2
gene id: 9615:TIGD2
uniprot id: A0A8C0PV81
uniprot id: A0A8I3NYE6
names: Subcellular Location Annotation
messages: Nucleus

9615:COPS7A
gene id: 9615:COPS7A
uniprot id: A0A8C0TR92
uniprot id: A0A8I3PVM0
uniprot id: A0A8P0SIZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9615:SERPINE2
gene id: 9615:SERPINE2
uniprot id: A0A8I3P2P6
names: Similarity
messages: Belongs to the serpin family.

9615:TSHZ3
gene id: 9615:TSHZ3
uniprot id: A0A8C0Q4I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

9615:GPBP1L1
gene id: 9615:GPBP1L1
uniprot id: A0A8C0NTK8
uniprot id: A0A8I3PDE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9615:SLIT1
gene id: 9615:SLIT1
uniprot id: A0A8C0TQL4
uniprot id: A0A8I3PVG4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:CLRN3
gene id: 9615:CLRN3
uniprot id: A0A8C0TIZ8
uniprot id: A0A8I3Q646
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9615:SORD
gene id: 9615:SORD
uniprot id: A0A8C0NKQ6
uniprot id: A0A8I3QI05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 1 or 2 Zn(2+) ions per subunit.
messages: Homotetramer.
messages: Mitochondrion membrane
messages: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.
messages: flagellum

9615:KIF3A
gene id: 9615:KIF3A
uniprot id: A0A8C0QA29
uniprot id: A0A8I3NH94
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:GIMAP1
gene id: 9615:GIMAP1
uniprot id: A0A8P0SA76
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9615:MS4A13
gene id: 9615:MS4A13
uniprot id: A0A8I3NW89
uniprot id: A0A8P0SYE6
names: Similarity
messages: Belongs to the MS4A family.

9615:GABRR1
gene id: 9615:GABRR1
uniprot id: A0A8C0YV54
uniprot id: A0A8I3NF20
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:HIGD2A
gene id: 9615:HIGD2A
uniprot id: A0A8P0TTD0
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9615:PCSK2
gene id: 9615:PCSK2
uniprot id: A0A8C0QBH0
uniprot id: A0A8I3P927
names: Similarity
messages: Belongs to the peptidase S8 family.

9615:ARG2
gene id: 9615:ARG2
uniprot id: A0A8C0SB48
uniprot id: A0A8I3MI74
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9615:TIMP2
gene id: 9615:TIMP2
uniprot id: Q9TTY1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
messages: Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.
messages: Secreted
messages: The activity of TIMP2 is dependent on the presence of disulfide bonds.

9615:TEFM
gene id: 9615:TEFM
uniprot id: A0A8C0SJF5
uniprot id: A0A8I3NQ15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEFM family.
messages: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
messages: mitochondrion nucleoid

9615:ETHE1
gene id: 9615:ETHE1
uniprot id: A0A8C0MEQ2
uniprot id: A0A8I3MYP1
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9615:ACOX2
gene id: 9615:ACOX2
uniprot id: A0A8P0SCI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9615:ATL1
gene id: 9615:ATL1
uniprot id: A0A8C0PWU7
uniprot id: A0A8C0PX24
uniprot id: A0A8I3RSN6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9615:ATP5F1A
gene id: 9615:ATP5F1A
uniprot id: A0A1B1X469
uniprot id: A0A8C0QKG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9615:H2BC13
gene id: 9615:H2BC13
uniprot id: A0A8C0P6N2
uniprot id: H9GWB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:CPSF4
gene id: 9615:CPSF4
uniprot id: A0A8C0QJF2
uniprot id: A0A8I3RSW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9615:CD40
gene id: 9615:CD40
uniprot id: Q7YRL5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).
messages: Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).

9615:MAB21L3
gene id: 9615:MAB21L3
uniprot id: A0A8C0SBK5
uniprot id: A0A8I3Q4Q5
names: Similarity
messages: Belongs to the mab-21 family.

9615:CYP1A2
gene id: 9615:CYP1A2
uniprot id: Q5R2U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9615:PROKR2
gene id: 9615:PROKR2
uniprot id: A0A8C0P145
uniprot id: A0A8I3PUU0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:MDM2
gene id: 9615:MDM2
uniprot id: P56950
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autoubiquitination leads to proteasomal degradation; resulting in p53/TP53 activation it may be regulated by SFN. Also ubiquitinated by TRIM13. Deubiquitinated by USP2 leads to its accumulation and increases deubiquitination and degradation of p53/TP53. Deubiquitinated by USP7 leading to its stabilization.
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells. Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (By similarity). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (By similarity).
messages: Interacts with p53/TP53, TP73/p73, RBL5 and RP11. Binds specifically to RNA. Can interact with RB1, E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with p53/TP53 and WWOX. Interacts with CDKN2AIP, RFWD3, USP7, PYHIN1 and RBBP6. Interacts with ARRB1 and ARRB2. Interacts with PSMA3. Found in a trimeric complex with MDM2, MDM4 and USP2. Interacts with USP2 (via N-terminus and C-terminus). Interacts with MDM4. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7. Interacts directly with DAXX and USP7. Interacts (via C-terminus) with RASSF1 isoform A (via N-terminus); the interaction is independent of TP53. Interacts with APEX1; leading to its ubiquitination and degradation. Interacts with RYBP; this inhibits ubiquitination of TP53. Identified in a complex with RYBP and p53/TP53. Also a component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in regulating p53/TP53 stabilization and activity. Binds directly both p53/TP53 and TRIM28. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor responses with DNA damage. Interacts directly with both TRIM28 and ERBB4 in the complex. Interacts with DYRK2. Interacts with IGF1R. Interacts with TRIM13; the interaction ubiquitinates MDM2 leading to its proteasomal degradation. Interacts with SNAI1; this interaction promotes SNAI1 ubiquitination. Interacts with NOTCH1 (via intracellular domain). Interacts with FHIT. Interacts with RFFL and RNF34; the interaction stabilizes MDM2. Interacts with CDK5RAP3 and CDKN2A/ARF; form a ternary complex involved in regulation of p53/TP53. Interacts with MTA1. Interacts with AARB2. Interacts with MTBP. Interacts with PML. Interacts with RPL11. Interacts with TBRG1. Interacts with the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11; the interaction is direct occurs in the nucleoplasm and negatively regulates MDM2-mediated TP53 ubiquitination and degradation. Interacts with ADGRB1;…
messages: Isoform Mdm2-alpha is present in lymphoid and testicular tissues.
messages: Nucleus
messages: Phosphorylation on Ser-166 by SGK1 activates ubiquitination of p53/TP53. Phosphorylated at multiple sites near the RING domain by ATM upon DNA damage; this prevents oligomerization and E3 ligase processivity and impedes constitutive p53/TP53 degradation (By similarity).
messages: Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73 and E2F1. Region II contains most of a central acidic region required for interaction with ribosomal protein L5 and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc interacts specifically with RNA whether or not zinc is present and mediates the heterooligomerization with MDM4. It is also essential for its ubiquitin ligase E3 activity toward p53 and itself (By similarity). Interacts with IGF1R (By similarity).
messages: nucleolus
messages: nucleoplasm

9615:TACR2
gene id: 9615:TACR2
uniprot id: Q5DUB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).

9615:MMRN1
gene id: 9615:MMRN1
uniprot id: A0A8C0T420
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:ANKS1B
gene id: 9615:ANKS1B
uniprot id: A0A8C0RNA6
uniprot id: A0A8I3SAZ4
names: Subcellular Location Annotation
messages: Cytoplasm

9615:APOD
gene id: 9615:APOD
uniprot id: A0A8C0PAS7
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9615:POLB
gene id: 9615:POLB
uniprot id: A0A8C0QAM8
uniprot id: A0A8I3NDB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9615:IFI6
gene id: 9615:IFI6
uniprot id: A0A8I3NGJ0
uniprot id: A0A8P0SGT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9615:MYOC
gene id: 9615:MYOC
uniprot id: Q2PT31
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell projection
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Expressed in optic nerve head, ciliary body and retina.
messages: Golgi apparatus
messages: Homodimer (via N-terminus). Can also form higher oligomers. Interacts with OLFM3, FN1, NRCAM, GLDN and NFASC. Interacts (via N-terminus) with MYL2. Interacts with SFRP1, FRZB, FZD7, FZD10, FZD1 and WIF1; regulates Wnt signaling (By similarity). Interacts with SNTA1; regulates muscle hypertrophy. Interacts with ERBB2 and ERBB3; activates ERBB2-ERBB3 signaling pathway. Interacts with SNCG; affects its secretion and its aggregation (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Mitochondrion outer membrane
messages: N-glycosylated.
messages: Palmitoylated.
messages: Rough endoplasmic reticulum
messages: Secreted
messages: Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.
messages: Undergoes a calcium-dependent proteolytic cleavage at Arg-205 by CAPN2 in the endoplasmic reticulum. The result is the production of two fragments, one of 35 kDa containing the C-terminal olfactomedin-like domain, and another of 20 kDa containing the N-terminal leucine zipper-like domain (By similarity).
messages: cilium
messages: extracellular exosome
messages: extracellular matrix
messages: extracellular space

9615:FUT10
gene id: 9615:FUT10
uniprot id: Q5F2N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. Postulated to generate core alpha(1->3)-fucose epitope within the chitobiose unit of biantennary N-glycans, providing for a recognition signal to reorient aberrantly folded glycoproteins for degradation (By similarity). Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (By similarity).

9615:CPEB4
gene id: 9615:CPEB4
uniprot id: A0A8C0LXN5
uniprot id: A0A8C0M2T2
uniprot id: A0A8C0M321
uniprot id: A0A8P0PCZ1
names: Similarity
messages: Belongs to the RRM CPEB family.

9615:YEATS2
gene id: 9615:YEATS2
uniprot id: A0A8C0Z4T9
uniprot id: A0A8I3PLS0
names: Subcellular Location Annotation
messages: Nucleus

9615:CSNK1A1
gene id: 9615:CSNK1A1
uniprot id: A0A8C0SDG5
uniprot id: A0A8I3N6W0
uniprot id: A0A8P0NJM6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:TPI1
gene id: 9615:TPI1
uniprot id: A0A346M2B2
uniprot id: P54714
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

9615:SNURF
gene id: 9615:SNURF
uniprot id: A0A8C0S284
names: Similarity
messages: Belongs to the SNURF family.

9615:ODF2
gene id: 9615:ODF2
uniprot id: A0A8C0LQT4
uniprot id: A0A8C0LRE5
uniprot id: A0A8C0LVM3
uniprot id: A0A8C0SH37
uniprot id: A0A8I3PZ47
uniprot id: A0A8I3Q5N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9615:GNG2
gene id: 9615:GNG2
uniprot id: A0A8P0PFL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:PDE1A
gene id: 9615:PDE1A
uniprot id: A0A8P0NM13
uniprot id: Q95NB8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:ROMO1
gene id: 9615:ROMO1
uniprot id: A0A8C0S4D2
uniprot id: A0A8I3PKB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9615:GRIK5
gene id: 9615:GRIK5
uniprot id: A0A8C0QFS4
uniprot id: A0A8I3MJM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9615:LOC100049001
gene id: 9615:LOC100049001
uniprot id: P15944
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family. Tryptase subfamily.
messages: Homotetramer.
messages: Secreted
messages: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.

9615:TNKS
gene id: 9615:TNKS
uniprot id: A0A8C0RY64
uniprot id: A0A8I3RZQ8
names: Function
names: Similarity
messages: Belongs to the ARTD/PARP family.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9615:LOC475395
gene id: 9615:LOC475395
uniprot id: A0A8C0MFN1
uniprot id: W0UTI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9615:PRPS2
gene id: 9615:PRPS2
uniprot id: A0A8C0RG12
uniprot id: A0A8I3QL09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9615:SLC48A1
gene id: 9615:SLC48A1
uniprot id: A0A8C0PNB6
uniprot id: A0A8I3PLR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

9615:KRT18
gene id: 9615:KRT18
uniprot id: A0A8C0PK81
uniprot id: A0A8I3PJ84
names: Similarity
messages: Belongs to the intermediate filament family.

9615:SMIM14
gene id: 9615:SMIM14
uniprot id: A0A8C0T6U5
uniprot id: A0A8I3MU08
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9615:MAPK1
gene id: 9615:MAPK1
uniprot id: A0A8C0TIJ2
uniprot id: A0A8I3PZP0
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola
messages: focal adhesion

9615:VASN
gene id: 9615:VASN
uniprot id: A0A8C0RCN8
uniprot id: A0A8I3MK79
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:MRPL22
gene id: 9615:MRPL22
uniprot id: A0A8C0RGD7
uniprot id: A0A8I3MQF3
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9615:SEMA3G
gene id: 9615:SEMA3G
uniprot id: A0A8C0TE37
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:LOC119863874
gene id: 9615:LOC119863874
uniprot id: A0A8C0RZG3
names: Subcellular Location Annotation
messages: Membrane

9615:GCNT3
gene id: 9615:GCNT3
uniprot id: A0A8I3P593
uniprot id: A0A8P0NI80
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9615:DKK3
gene id: 9615:DKK3
uniprot id: A0A8C0T1J9
uniprot id: W0RY37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9615:SNX3
gene id: 9615:SNX3
uniprot id: A0A8C0MYJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

9615:RXRB
gene id: 9615:RXRB
uniprot id: A0A8C0T8B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9615:PRKCG
gene id: 9615:PRKCG
uniprot id: A0A8C0RV32
uniprot id: E2R2X3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cytoplasm
messages: Membrane

9615:DHX58
gene id: 9615:DHX58
uniprot id: A0A8C0LX22
uniprot id: A0A8I3NFT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9615:FAM160A2
gene id: 9615:FAM160A2
uniprot id: A0A8C0MYF0
uniprot id: A0A8I3MTX3
names: Similarity
messages: Belongs to the FHIP family.

9615:SEC61A1
gene id: 9615:SEC61A1
uniprot id: P38377
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:10799540, PubMed:1423609). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:36261528). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (By similarity). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).
messages: Endoplasmic reticulum membrane
messages: The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:10799540, PubMed:1423609, PubMed:36261528). The SEC61 channel associates with the multi-pass translocon (MPT) complex (PubMed:36261528).

9615:HNRNPA3
gene id: 9615:HNRNPA3
uniprot id: A0A8C0P5A0
uniprot id: A0A8I3P0N1
names: Subcellular Location Annotation
messages: Nucleus

9615:SELP
gene id: 9615:SELP
uniprot id: A0A8C0Q3D2
uniprot id: A0A8I3MKI2
uniprot id: Q28290
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:ICOS
gene id: 9615:ICOS
uniprot id: Q7YR73
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
messages: Homodimer; disulfide-linked.
messages: Membrane
messages: N-glycosylated.

9615:HCCS
gene id: 9615:HCCS
uniprot id: A0A8C0MP16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9615:LOC100686103
gene id: 9615:LOC100686103
uniprot id: A0A8C0S4Y9
uniprot id: J9NZS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9615:ACVR1
gene id: 9615:ACVR1
uniprot id: A0A8C0MPL7
uniprot id: A0A8I3PSN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9615:INTS13
gene id: 9615:INTS13
uniprot id: E2R9F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

9615:DNAJC25
gene id: 9615:DNAJC25
uniprot id: A0A8C0SK74
names: Similarity
messages: Belongs to the DNAJC25 family.

9615:ACP7
gene id: 9615:ACP7
uniprot id: A0A8C0NN32
uniprot id: A0A8I3MUC8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

9615:NEK6
gene id: 9615:NEK6
uniprot id: A0A8C0MA68
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:CES1
gene id: 9615:CES1
uniprot id: Q95N05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9615:LOC609894
gene id: 9615:LOC609894
uniprot id: A0A8C0YUX5
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9615:PDIA3
gene id: 9615:PDIA3
uniprot id: A0A8C0NPX9
uniprot id: A0A8I3S5M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9615:TNFSF8
gene id: 9615:TNFSF8
uniprot id: A0A8C0QH86
uniprot id: E2R8I1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9615:DRD1
gene id: 9615:DRD1
uniprot id: A0A8I3RQT9
uniprot id: A0A8P0TS58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
messages: Membrane
messages: dendritic spine

9615:MOV10
gene id: 9615:MOV10
uniprot id: A0A8I3N0T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

9615:CLDN2
gene id: 9615:CLDN2
uniprot id: Q95KM6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).
messages: Cell membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking.
messages: tight junction

9615:HTT
gene id: 9615:HTT
uniprot id: A0A8C0Q3X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the huntingtin family.
messages: Cytoplasm
messages: May play a role in microtubule-mediated transport or vesicle function.
messages: Nucleus

9615:PXMP4
gene id: 9615:PXMP4
uniprot id: A0A8C0P028
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

9615:LBX2
gene id: 9615:LBX2
uniprot id: A0A8C0S084
uniprot id: A0A8I3NXJ5
names: Subcellular Location Annotation
messages: Nucleus

9615:NDC1
gene id: 9615:NDC1
uniprot id: A0A8I3NV53
uniprot id: A0A8I3P2N5
uniprot id: A0A8P0NKF3
uniprot id: A0A8P0SMQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

9615:GPNMB
gene id: 9615:GPNMB
uniprot id: A0A8C0RZN5
names: Similarity
messages: Belongs to the PMEL/NMB family.

9615:ANAPC15
gene id: 9615:ANAPC15
uniprot id: A0A8C0T7L4
uniprot id: A0A8I3NF53
names: Similarity
messages: Belongs to the APC15 family.

9615:MYH14
gene id: 9615:MYH14
uniprot id: A0A8C0SIH7
uniprot id: A0A8I3P8R0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9615:GGCX
gene id: 9615:GGCX
uniprot id: A0A8C0N2L1
uniprot id: A0A8I3NVM5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:LOC475405
gene id: 9615:LOC475405
uniprot id: A0A8C0MC76
uniprot id: A0A8I3SAM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9615:LOC100688697
gene id: 9615:LOC100688697
uniprot id: A0A8C0PJ27
uniprot id: A0A8I3PUA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:LRRC8A
gene id: 9615:LRRC8A
uniprot id: A0A8C0MGY0
uniprot id: A0A8I3PQW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9615:HDGFL2
gene id: 9615:HDGFL2
uniprot id: A0A8C0QAJ3
uniprot id: A0A8I3P2N8
names: Subcellular Location Annotation
messages: Nucleus

9615:GDE1
gene id: 9615:GDE1
uniprot id: A0A8C0P097
uniprot id: A0A8I3RWM9
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9615:FDFT1
gene id: 9615:FDFT1
uniprot id: A0A8C0NTL6
uniprot id: A0A8C0TGW2
uniprot id: A0A8I3P3D2
uniprot id: A0A8I3P8C5
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9615:LEPROT
gene id: 9615:LEPROT
uniprot id: A0A8C0QF75
uniprot id: A0A8C0QLL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9615:THBS2
gene id: 9615:THBS2
uniprot id: A0A8P0P0I2
uniprot id: D5IGC9
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CDC6
gene id: 9615:CDC6
uniprot id: A0A8C0PJY7
uniprot id: A0A8I3N5S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

9615:SNRPD2
gene id: 9615:SNRPD2
uniprot id: A0A8C0MB66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: cytosol

9615:AP1M1
gene id: 9615:AP1M1
uniprot id: A0A8C0T4S7
uniprot id: A0A8I3Q641
uniprot id: A0A8I3QA46
uniprot id: A0A8P0SJV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9615:APIP
gene id: 9615:APIP
uniprot id: A0A8C0Z008
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9615:RETREG1
gene id: 9615:RETREG1
uniprot id: A0A0K1MBN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:MYOZ1
gene id: 9615:MYOZ1
uniprot id: A0A8C0PX17
uniprot id: Q1AG03
names: Similarity
messages: Belongs to the myozenin family.

9615:LYPD2
gene id: 9615:LYPD2
uniprot id: A0A8I3NVD7
uniprot id: A0A8P0S780
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:FER1L5
gene id: 9615:FER1L5
uniprot id: A0A8P0N5G8
uniprot id: A0A8P0PPV0
names: Similarity
messages: Belongs to the ferlin family.

9615:CCNA2
gene id: 9615:CCNA2
uniprot id: A0A8C0MAN2
uniprot id: A0A8I3PCC0
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9615:PTGER3
gene id: 9615:PTGER3
uniprot id: Q6VPS4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:RCAN2
gene id: 9615:RCAN2
uniprot id: A0A8C0MK86
uniprot id: A0A8I3NHX7
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9615:SLC16A1
gene id: 9615:SLC16A1
uniprot id: A0A8I3MUJ6
uniprot id: A0A8P0NF50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9615:PPA2
gene id: 9615:PPA2
uniprot id: A0A8I3PUL1
uniprot id: A0A8P0PL71
names: Similarity
messages: Belongs to the PPase family.

9615:AURKB
gene id: 9615:AURKB
uniprot id: A0A8C0NZ38
uniprot id: A0A8C0QQK2
uniprot id: A0A8I3Q4W5
uniprot id: A0A8I3QG95
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

9615:NDUFV1
gene id: 9615:NDUFV1
uniprot id: A0A8C0S5T0
uniprot id: A0A8I3N636
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9615:LOC606788
gene id: 9615:LOC606788
uniprot id: A0A8C0PYQ4
names: Similarity
messages: Belongs to the SPATA31 family.

9615:PLIN2
gene id: 9615:PLIN2
uniprot id: A0A8C0MGR0
uniprot id: A0A8I3NVF1
names: Similarity
messages: Belongs to the perilipin family.

9615:ADA2
gene id: 9615:ADA2
uniprot id: A0A8C0T1G5
uniprot id: A0A8I3QB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

9615:LOC100856515
gene id: 9615:LOC100856515
uniprot id: A0A8C0PAN6
uniprot id: A0A8I3PVN3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9615:DPYSL2
gene id: 9615:DPYSL2
uniprot id: A0A8C0P7H6
uniprot id: A0A8C0Z1X3
uniprot id: A0A8I3NP20
uniprot id: A0A8I3NRS8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9615:AURKA
gene id: 9615:AURKA
uniprot id: A0A8P0NQ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9615:GMFG
gene id: 9615:GMFG
uniprot id: A0A8C0SLP7
uniprot id: A0A8C0SMU3
uniprot id: A0A8I3MUL5
uniprot id: A0A8I3MXF6
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9615:RETREG3
gene id: 9615:RETREG3
uniprot id: A0A8C0QJ10
uniprot id: A0A8I3MY43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:MAPK6
gene id: 9615:MAPK6
uniprot id: A0A8C0TRN7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9615:FSCN3
gene id: 9615:FSCN3
uniprot id: A0A8C0MU63
uniprot id: A0A8I3PW46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9615:ETV1
gene id: 9615:ETV1
uniprot id: A0A8C0T546
uniprot id: A0A8C0Z286
uniprot id: A0A8I3PR30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:JRK
gene id: 9615:JRK
uniprot id: A0A8C0MWT8
uniprot id: A0A8I3NGS2
names: Subcellular Location Annotation
messages: Nucleus

9615:SGO2
gene id: 9615:SGO2
uniprot id: A0A8I3PWS1
uniprot id: A0A8P0NDA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9615:EDNRA
gene id: 9615:EDNRA
uniprot id: Q5KSU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).

9615:SCARA5
gene id: 9615:SCARA5
uniprot id: A0A8C0PKL5
uniprot id: A0A8I3NCP4
uniprot id: A0A8P0NAK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9615:CEP57L1
gene id: 9615:CEP57L1
uniprot id: A0A8P0TMP2
names: Similarity
messages: Belongs to the translokin family.

9615:TP53BP1
gene id: 9615:TP53BP1
uniprot id: A0A8C0NNN4
uniprot id: A0A8I3S796
names: Subcellular Location Annotation
messages: Nucleus

9615:EMG1
gene id: 9615:EMG1
uniprot id: A0A8C0NYH7
uniprot id: A0A8I3PLM1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9615:BAP1
gene id: 9615:BAP1
uniprot id: A0A8C0MP98
uniprot id: A0A8I3QAS2
names: Similarity
messages: Belongs to the peptidase C12 family.

9615:HMGB2
gene id: 9615:HMGB2
uniprot id: A0A8C0TCZ5
uniprot id: A0A8I3P9Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9615:ARF4
gene id: 9615:ARF4
uniprot id: A0A8C0PK84
uniprot id: A0A8I3PMI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9615:OCIAD1
gene id: 9615:OCIAD1
uniprot id: A0A8C0SFC6
uniprot id: A0A8I3RXW0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

9615:PFKL
gene id: 9615:PFKL
uniprot id: A0A8C0PFZ8
uniprot id: A0A8I3PBD8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:GMFB
gene id: 9615:GMFB
uniprot id: A0A8C0M1Q3
uniprot id: A0A8C0Q0Q7
uniprot id: A0A8I3MTV9
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9615:OR2T2
gene id: 9615:OR2T2
uniprot id: A0A8P0S776
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:GSTP1
gene id: 9615:GSTP1
uniprot id: A0A8C0S5S6
uniprot id: A0A8I3QRM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

9615:FCGRT
gene id: 9615:FCGRT
uniprot id: A0A8C0SWK8
uniprot id: A0A8I3PFR8
names: Similarity
messages: Belongs to the MHC class I family.

9615:DNASE1L3
gene id: 9615:DNASE1L3
uniprot id: A0A8C0QQM4
uniprot id: A0A8I3P4R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Nucleus envelope
messages: Zymogen granule

9615:TEKT1
gene id: 9615:TEKT1
uniprot id: A0A8C0RUM1
uniprot id: A0A8I3MF23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9615:ALDH4A1
gene id: 9615:ALDH4A1
uniprot id: A0A8C0N6F0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:SCARB2
gene id: 9615:SCARB2
uniprot id: A0A8C0TQJ6
uniprot id: A0A8I3Q374
names: Similarity
messages: Belongs to the CD36 family.

9615:SNRPD1
gene id: 9615:SNRPD1
uniprot id: A0A8C0PT23
uniprot id: A0A8I3NN15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

9615:XRCC1
gene id: 9615:XRCC1
uniprot id: A0A8C0SJ49
uniprot id: A0A8I3MFG7
names: Subcellular Location Annotation
messages: Nucleus

9615:IL15
gene id: 9615:IL15
uniprot id: A0A8C0NA66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9615:ORC6
gene id: 9615:ORC6
uniprot id: A0A8C0S415
uniprot id: A0A8I3PA93
uniprot id: A0A8P0TH40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9615:PTGIR
gene id: 9615:PTGIR
uniprot id: A0A8I3MUB8
uniprot id: A0A8P0PPL3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:KCNK5
gene id: 9615:KCNK5
uniprot id: A0A8C0MJX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9615:SLC15A1
gene id: 9615:SLC15A1
uniprot id: Q8WMX5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (By similarity). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system (By similarity).
messages: Interacts (via extracellular domain region) with trypsin.
messages: The extracellular domain (ECD) region specifically binds trypsin.

9615:LOC100685611
gene id: 9615:LOC100685611
uniprot id: A0A8C0S4Y9
uniprot id: J9NZS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9615:NTRK2
gene id: 9615:NTRK2
uniprot id: A0A8C0PN47
uniprot id: A0A8C0PPL3
uniprot id: A0A8I3MQS1
uniprot id: A0A8I3RSL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9615:SERPINA1
gene id: 9615:SERPINA1
uniprot id: A0A8P0SPL0
names: Similarity
messages: Belongs to the serpin family.

9615:HMGN3
gene id: 9615:HMGN3
uniprot id: A0A8C0MR89
uniprot id: A0A8I3N122
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9615:COA5
gene id: 9615:COA5
uniprot id: A0A8C0YZQ4
uniprot id: A0A8I3NY56
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9615:DSTYK
gene id: 9615:DSTYK
uniprot id: Q4VSN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm

9615:MED23
gene id: 9615:MED23
uniprot id: A0A8I3MZX7
uniprot id: A0A8I3NE00
uniprot id: A0A8P0SYI1
uniprot id: A0A8P0T2B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

9615:PPP2R5B
gene id: 9615:PPP2R5B
uniprot id: A0A8C0TEY5
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9615:TSPAN8
gene id: 9615:TSPAN8
uniprot id: A0A8C0S7T2
uniprot id: A0A8I3PI03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:NAPB
gene id: 9615:NAPB
uniprot id: A0A8C0P589
uniprot id: A0A8C0TIL3
uniprot id: A0A8I3PZJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9615:C5H11orf87
gene id: 9615:C5H11orf87
uniprot id: A0A8I3MHJ3
uniprot id: A0A8P0NM96
names: Subcellular Location Annotation
messages: Membrane

9615:SULT1C4
gene id: 9615:SULT1C4
uniprot id: A0A8C0YZR2
uniprot id: A0A8I3N072
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:XPOT
gene id: 9615:XPOT
uniprot id: A0A8C0N5R6
uniprot id: A0A8C0N666
uniprot id: A0A8I3N717
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9615:PSMD13
gene id: 9615:PSMD13
uniprot id: A0A8C0TIV2
uniprot id: A0A8I3S6Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9615:S1PR1
gene id: 9615:S1PR1
uniprot id: W5VNF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:GPR50
gene id: 9615:GPR50
uniprot id: A0A8C0SUJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:RAD17
gene id: 9615:RAD17
uniprot id: A0A8P0SD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

9615:CDC25C
gene id: 9615:CDC25C
uniprot id: A0A8C0M853
uniprot id: A0A8I3PBM4
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9615:PRMT5
gene id: 9615:PRMT5
uniprot id: A0A8C0PPS3
uniprot id: A0A8C0RV99
uniprot id: A0A8I3MM19
uniprot id: A0A8I3RQT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9615:NIPSNAP2
gene id: 9615:NIPSNAP2
uniprot id: A0A8C0LSW1
uniprot id: A0A8C0LTB0
uniprot id: A0A8I3NCW1
uniprot id: A0A8I3NCZ6
names: Similarity
messages: Belongs to the NipSnap family.

9615:SLC35B3
gene id: 9615:SLC35B3
uniprot id: A0A8I3P444
uniprot id: A0A8I3P5Z8
uniprot id: A0A8P0SXN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9615:GCDH
gene id: 9615:GCDH
uniprot id: A0A8C0RNJ3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9615:TMEM170A
gene id: 9615:TMEM170A
uniprot id: A0A8C0M4B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9615:CREM
gene id: 9615:CREM
uniprot id: P79145
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a dimer. Interacts with FHL5. Interacts with CDC34. May interact with TSSK4.
messages: Nucleus
messages: Stimulated by phosphorylation. Phosphorylated on Ser-118 by TSSK4 in vitro.
messages: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform Tau is a transcriptional activator. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity).

9615:SLC31A2
gene id: 9615:SLC31A2
uniprot id: A0A8C0SSG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9615:PPM1A
gene id: 9615:PPM1A
uniprot id: A0A8C0Q407
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9615:VPS37D
gene id: 9615:VPS37D
uniprot id: A0A8C0S8R6
uniprot id: A0A8I3N530
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9615:MOCS1
gene id: 9615:MOCS1
uniprot id: A0A8C0MP85
uniprot id: A0A8I3S0Z8
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

9615:MPPED2
gene id: 9615:MPPED2
uniprot id: A0A8C0NNS6
uniprot id: A0A8I3QJJ0
names: Similarity
messages: Belongs to the UPF0046 family.

9615:KRT39
gene id: 9615:KRT39
uniprot id: A0A8P0NLV5
names: Similarity
messages: Belongs to the intermediate filament family.

9615:PTGES3L
gene id: 9615:PTGES3L
uniprot id: A0A8P0TTU5
names: Similarity
messages: Belongs to the p23/wos2 family.

9615:CALCB
gene id: 9615:CALCB
uniprot id: Q75V94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted
messages: Stimulates cAMP production in porcine kidney cell line LLC-PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor.

9615:FGB
gene id: 9615:FGB
uniprot id: A0A8C0SGZ1
uniprot id: A0A8I3NBD6
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9615:RAB3A
gene id: 9615:RAB3A
uniprot id: A0A8C0RM23
uniprot id: A0A8I3PDP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9615:MYO1D
gene id: 9615:MYO1D
uniprot id: A0A8C0SC17
uniprot id: A0A8I3NWD6
uniprot id: F1PRN2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Binds a calmodulin chain via each of the two IQ domains. IQ domain 1 mediates interaction with calmodulin both in the presence and in the absence of Ca(2+). IQ domain 2 mediates interaction with calmodulin in the presence of Ca(2+).
messages: Contrary to the situation in zebrafish, xenopus and drosophila, mammalian MYO1D defects have no effects on left-right body asymmetry.
messages: Cytoplasm
messages: Early endosome
messages: Interacts (via the two IQ motifs) with calmodulin (PubMed:11208135). Binds an additional calmodulin chain via a third, C-terminal region. Interacts with F-actin (By similarity).
messages: Perikaryon
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).
messages: The TH1 domain is required for activity in complementing zebrafish defects in Kupffer's vesicle lumen size.
messages: Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (PubMed:11208135). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity).
messages: cell cortex
messages: dendrite

9615:PDGFRA
gene id: 9615:PDGFRA
uniprot id: A0A8C0STE2
uniprot id: A0A8I3NAN8
uniprot id: A0A8P0N541
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9615:TSPAN1
gene id: 9615:TSPAN1
uniprot id: A0A8C0SU32
uniprot id: A0A8I3P9L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:TMEM17
gene id: 9615:TMEM17
uniprot id: A0A8P0S8U9
names: Subcellular Location Annotation
messages: Membrane

9615:B2M
gene id: 9615:B2M
uniprot id: A0A8C0NI65
uniprot id: E2RN10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-2-microglobulin family.
messages: Secreted

9615:RBX1
gene id: 9615:RBX1
uniprot id: A0A8C0T401
uniprot id: A0A8I3NXW3
names: Similarity
messages: Belongs to the RING-box family.

9615:MAPK1IP1L
gene id: 9615:MAPK1IP1L
uniprot id: A0A8C0PQ41
uniprot id: A0A8I3NW87
names: Similarity
messages: Belongs to the MISS family.

9615:B3GNT3
gene id: 9615:B3GNT3
uniprot id: A0A8P0NGP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:GORASP2
gene id: 9615:GORASP2
uniprot id: A0A8C0N2V7
uniprot id: A0A8I3SA28
names: Similarity
messages: Belongs to the GORASP family.

9615:FAM114A1
gene id: 9615:FAM114A1
uniprot id: A0A8I3MPK4
uniprot id: A0A8P0SKM0
names: Similarity
messages: Belongs to the FAM114 family.

9615:INO80C
gene id: 9615:INO80C
uniprot id: A0A8C0MA43
uniprot id: A0A8I3MYN8
names: Subcellular Location Annotation
messages: Nucleus

9615:LOC100687115
gene id: 9615:LOC100687115
uniprot id: A0A8C0Q2C0
uniprot id: A0A8I3N7Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9615:IKBKE
gene id: 9615:IKBKE
uniprot id: A0A8P0T6W4
uniprot id: A0A8P0TEM4
names: Subcellular Location Annotation
messages: Cytoplasm

9615:TENT5A
gene id: 9615:TENT5A
uniprot id: A0A8C0MFA5
uniprot id: A0A8C0MFE8
uniprot id: A0A8C0Q6W6
uniprot id: A0A8I3NC99
names: Similarity
messages: Belongs to the TENT family.

9615:FGF11
gene id: 9615:FGF11
uniprot id: A0A8C0QBH8
uniprot id: J9NU39
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:IFT46
gene id: 9615:IFT46
uniprot id: A0A8C0MF20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

9615:ARHGDIB
gene id: 9615:ARHGDIB
uniprot id: A0A8C0TMJ5
uniprot id: A0A8I3P6H9
names: Similarity
messages: Belongs to the Rho GDI family.

9615:HPX
gene id: 9615:HPX
uniprot id: A0A8C0T7L3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Secreted

9615:RELL2
gene id: 9615:RELL2
uniprot id: A0A8C0QAB7
names: Similarity
messages: Belongs to the RELT family.

9615:NMB
gene id: 9615:NMB
uniprot id: A0A8C0RWX7
uniprot id: A0A8I3MML2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

9615:RPS19
gene id: 9615:RPS19
uniprot id: A0A8C0RBJ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

9615:SUMO2
gene id: 9615:SUMO2
uniprot id: A0A8C0Q4G0
uniprot id: A0A8I3Q1K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9615:VEGFD
gene id: 9615:VEGFD
uniprot id: A0A8C0YXI0
uniprot id: A0A8I3SCC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9615:LOC482436
gene id: 9615:LOC482436
uniprot id: A0A8C0RSD1
uniprot id: A0A8I3NW23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

9615:MSX2
gene id: 9615:MSX2
uniprot id: Q9GK08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).
messages: Belongs to the Msh homeobox family.
messages: Interacts with MINT, with XRCC6 (Ku70) and XRCC5 (Ku80).
messages: Nucleus

9615:CXCL8
gene id: 9615:CXCL8
uniprot id: P41324
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
messages: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
messages: Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.
messages: Secreted

9615:KCNAB1
gene id: 9615:KCNAB1
uniprot id: A0A8C0NNK3
uniprot id: A0A8C0T476
uniprot id: A0A8I3PCA7
uniprot id: A0A8I3PCH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9615:NKX6-3
gene id: 9615:NKX6-3
uniprot id: A0A8C0NXP1
uniprot id: A0A8I3MZB4
names: Subcellular Location Annotation
messages: Nucleus

9615:B4GALNT3
gene id: 9615:B4GALNT3
uniprot id: A0A8P0NHD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

9615:ADORA3
gene id: 9615:ADORA3
uniprot id: Q28309
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.

9615:NEFL
gene id: 9615:NEFL
uniprot id: A0A8C0TAX3
uniprot id: A0A8I3NI39
names: Similarity
messages: Belongs to the intermediate filament family.

9615:MEOX1
gene id: 9615:MEOX1
uniprot id: A0A8C0T3I9
uniprot id: A0A8I3RY40
names: Subcellular Location Annotation
messages: Nucleus

9615:CCDC85B
gene id: 9615:CCDC85B
uniprot id: A0A8C0SQY2
uniprot id: A0A8I3P0N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9615:COX5A
gene id: 9615:COX5A
uniprot id: A0A8C0T931
uniprot id: A0A8I3S3K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9615:OR4P6
gene id: 9615:OR4P6
uniprot id: A0A8C0SHX6
uniprot id: A0A8I3RTZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:TNFSF14
gene id: 9615:TNFSF14
uniprot id: A0A8C0P717
uniprot id: J9P753
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9615:LOC479668
gene id: 9615:LOC479668
uniprot id: A0A8C0T540
uniprot id: A0A8I3N4M8
names: Caution
names: Function
names: Similarity
messages: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:FXN
gene id: 9615:FXN
uniprot id: A0A8C0PRQ8
uniprot id: A6Q0K4
names: Similarity
messages: Belongs to the frataxin family.

9615:SCNM1
gene id: 9615:SCNM1
uniprot id: A0A8C0SF58
uniprot id: A0A8I3PPR7
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: nucleoplasm

9615:FCER1G
gene id: 9615:FCER1G
uniprot id: A0A8C0NYM6
uniprot id: A0A8I3QSK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9615:VN1R4
gene id: 9615:VN1R4
uniprot id: Q8MIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:NME2
gene id: 9615:NME2
uniprot id: Q50KA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6) (By similarity). Interacts with CAPN8 (By similarity). Interacts with AKAP13 (By similarity). Interacts with ITGB1BP1 (via C-terminal domain region) (By similarity). Interacts with BCL2L10 (By similarity).
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not. Exhibits histidine protein kinase activity (By similarity).
messages: Nucleus
messages: Ubiquitous.
messages: lamellipodium
messages: ruffle

9615:PYM1
gene id: 9615:PYM1
uniprot id: A0A8C0NJ10
uniprot id: A0A8I3NC42
names: Similarity
names: Subunit
messages: Belongs to the pym family.
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

9615:LASP1
gene id: 9615:LASP1
uniprot id: A0A8C0M9V5
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

9615:LIFR
gene id: 9615:LIFR
uniprot id: Q5XNR9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR (By similarity).
messages: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.

9615:VAPB
gene id: 9615:VAPB
uniprot id: A0A8C0NQV2
uniprot id: A0A8I3NZT7
uniprot id: A0A8P0TTU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:PIGG
gene id: 9615:PIGG
uniprot id: A0A8C0RPX3
uniprot id: A0A8I3MLA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:SPOUT1
gene id: 9615:SPOUT1
uniprot id: A0A8C0MG38
uniprot id: A0A8I3S5N0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

9615:LOC100684060
gene id: 9615:LOC100684060
uniprot id: A0A8C0Z038
uniprot id: A0A8I3PEE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:UBE2C
gene id: 9615:UBE2C
uniprot id: A0A8C0NK86
uniprot id: A0A8I3NT10
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:CYB5RL
gene id: 9615:CYB5RL
uniprot id: A0A8C0M5R8
uniprot id: A0A8I3RYN6
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9615:SRD5A1
gene id: 9615:SRD5A1
uniprot id: A0A8P0P128
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane
messages: Microsome membrane

9615:OASL
gene id: 9615:OASL
uniprot id: A0A8P0NCS1
uniprot id: Q2KM15
names: Similarity
messages: Belongs to the 2-5A synthase family.

9615:CCR3
gene id: 9615:CCR3
uniprot id: Q64H34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1.

9615:CRAT
gene id: 9615:CRAT
uniprot id: A0A8C0RE63
uniprot id: A0A8C0S4S8
uniprot id: A0A8I3PPI0
uniprot id: A0A8I3PVL0
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9615:HS2ST1
gene id: 9615:HS2ST1
uniprot id: A0A8C0QL60
uniprot id: A0A8I3S128
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:RNF135
gene id: 9615:RNF135
uniprot id: A0A8C0P6X6
uniprot id: A0A8I3NFN7
names: Subcellular Location Annotation
messages: Cytoplasm

9615:NHEJ1
gene id: 9615:NHEJ1
uniprot id: A0A8C0TQV2
uniprot id: J9P1R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

9615:HIBADH
gene id: 9615:HIBADH
uniprot id: A0A8C0S5K4
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

9615:PTS
gene id: 9615:PTS
uniprot id: A0A8I3RRF3
uniprot id: A0A8P0SIF8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9615:TPM1
gene id: 9615:TPM1
uniprot id: A0A0N9JIB9
uniprot id: A0A8I3P7B2
uniprot id: A0A8I3PBQ8
uniprot id: A0A8I3PIT5
uniprot id: A0A8P0T4B8
uniprot id: A0A8P0TFM2
uniprot id: A0A8P0TKC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9615:YIPF6
gene id: 9615:YIPF6
uniprot id: A0A8C0TDZ9
uniprot id: A0A8I3PZS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:AOC3
gene id: 9615:AOC3
uniprot id: A0A8C0TAI5
uniprot id: A0A8I3MYY3
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9615:FGD5
gene id: 9615:FGD5
uniprot id: A0A8C0T1Q2
uniprot id: A0A8I3PW48
names: Subcellular Location Annotation
messages: cytoskeleton

9615:GDAP2
gene id: 9615:GDAP2
uniprot id: A0A8C0SIC4
uniprot id: A0A8I3NCQ2
names: Similarity
messages: Belongs to the GDAP2 family.

9615:RNF145
gene id: 9615:RNF145
uniprot id: A0A8C0Q2V4
uniprot id: A0A8I3MYL1
names: Subcellular Location Annotation
messages: Membrane

9615:CCNB3
gene id: 9615:CCNB3
uniprot id: Q659K0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I (By similarity).
messages: Interacts with CDK2 kinase.
messages: Nucleus
messages: The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: Ubiquitinated (Probable). Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1 (By similarity).

9615:NARF
gene id: 9615:NARF
uniprot id: A0A8C0QLX2
names: Similarity
messages: Belongs to the NARF family.

9615:STARD8
gene id: 9615:STARD8
uniprot id: A0A8I3PWZ9
uniprot id: A0A8I3QPP4
uniprot id: A0A8P0NIA5
uniprot id: A0A8P0PDM7
names: Subcellular Location Annotation
messages: Cytoplasm

9615:MYCBP
gene id: 9615:MYCBP
uniprot id: A0A8C0Q3B3
uniprot id: J9P9G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

9615:POU4F2
gene id: 9615:POU4F2
uniprot id: A0A8C0QMF3
uniprot id: A0A8I3NYY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9615:NT5DC3
gene id: 9615:NT5DC3
uniprot id: A0A8P0N9Q7
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9615:SLC25A38
gene id: 9615:SLC25A38
uniprot id: A0A8C0T8I6
uniprot id: A0A8I3NZ23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9615:CASP6
gene id: 9615:CASP6
uniprot id: A0A8C0Z5M7
uniprot id: A0A8I3Q9U5
names: Similarity
messages: Belongs to the peptidase C14A family.

9615:TCP11
gene id: 9615:TCP11
uniprot id: A0A8C0YYU7
names: Similarity
messages: Belongs to the TCP11 family.

9615:VLDLR
gene id: 9615:VLDLR
uniprot id: A0A8C0N5Z3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:OR5A3
gene id: 9615:OR5A3
uniprot id: A0A8C0RMU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:DHRS9
gene id: 9615:DHRS9
uniprot id: A0A8C0P7Q2
uniprot id: A0A8I3PAT8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:RPS6KA1
gene id: 9615:RPS6KA1
uniprot id: A0A8C0N7U1
uniprot id: A0A8C0QBW0
uniprot id: A0A8I3NKU8
uniprot id: A0A8I3NMQ4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9615:NFXL1
gene id: 9615:NFXL1
uniprot id: A0A8C0RJP0
uniprot id: A0A8I3RV90
names: Similarity
messages: Belongs to the NFX1 family.

9615:SLC11A1
gene id: 9615:SLC11A1
uniprot id: Q9XT74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

9615:ESD
gene id: 9615:ESD
uniprot id: A0A8C0SIU9
uniprot id: A0A8I3MU76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9615:PDE1B
gene id: 9615:PDE1B
uniprot id: A0A8C0SZ88
uniprot id: A0A8C0SZN7
uniprot id: A0A8C0T2R1
uniprot id: A0A8I3P1C7
uniprot id: A0A8I3S1V6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:HGS
gene id: 9615:HGS
uniprot id: A0A8C0NLR7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
messages: multivesicular body membrane

9615:SPCS1
gene id: 9615:SPCS1
uniprot id: A0A8C0M9Q2
uniprot id: P83362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SPCS1 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:3511473). Dispensable for SPC enzymatic activity (By similarity).
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SPCS2 and SPCS3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
messages: Endoplasmic reticulum membrane
messages: Expressed in the pancreas (at protein level).
messages: May be phosphorylated.
messages: Membrane

9615:PKLR
gene id: 9615:PKLR
uniprot id: Q29536
names: Activity Regulation
names: Disease Annotation
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate.
messages: Belongs to the pyruvate kinase family.
messages: Defects in PKLR are a cause of inherited hemolytic anemia, an autosomal recessive disease of the Basenji dog that closely resembles human pyruvate kinase deficiency.
messages: Derived from EST data.
messages: Homotetramer.
messages: Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis.
messages: There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. L type is major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues.

9615:IGF1
gene id: 9615:IGF1
uniprot id: P33712
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.
messages: Secreted
messages: The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. A major quantitative trait locus (QTL) on chromosome 15 influences size variation within a single breed. In particular, a single-nucleotide polymorphism haplotype in IGF1 (synonymous SNP in exon 3) is common to all small breeds (less than 9 kg) and nearly absent from giant breeds (more than 30 kg), suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).

9615:ST6GALNAC1
gene id: 9615:ST6GALNAC1
uniprot id: Q00M93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:C10H2orf49
gene id: 9615:C10H2orf49
uniprot id: A0A8C0P9S8
uniprot id: A0A8C0QEH7
uniprot id: A0A8I3N255
uniprot id: A0A8I3NEV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9615:GALK2
gene id: 9615:GALK2
uniprot id: A0A8C0MLJ8
uniprot id: A0A8C0MVA7
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9615:HGD
gene id: 9615:HGD
uniprot id: A0A8C0MZ30
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9615:DAZL
gene id: 9615:DAZL
uniprot id: A0A8C0PAJ4
names: Subcellular Location Annotation
messages: Cytoplasm

9615:CNPY2
gene id: 9615:CNPY2
uniprot id: A0A8C0NGE4
uniprot id: A0A8I3RVQ5
names: Similarity
messages: Belongs to the canopy family.

9615:HMGCS1
gene id: 9615:HMGCS1
uniprot id: A0A8I3MM03
uniprot id: A0A8P0SMM6
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9615:NCLN
gene id: 9615:NCLN
uniprot id: A0A8C0S144
uniprot id: A0A8I3NGV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nicastrin family.
messages: Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO1 and TMEM147 (PubMed:36261528). The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47) (PubMed:36261528). The MPT complex associates with the SEC61 complex (PubMed:36261528).
messages: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261528). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261528). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity).
messages: Endoplasmic reticulum membrane
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

9615:IARS1
gene id: 9615:IARS1
uniprot id: A0A8C0M0E3
uniprot id: A0A8I3M9Y6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:F8
gene id: 9615:F8
uniprot id: O18806
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
messages: Interacts with vWF. vWF binding is essential for the stabilization of F8 in circulation (By similarity).
messages: Proteolytically cleaved by cathepsin CTSG to produce a partially activated form.
messages: extracellular space

9615:CENPK
gene id: 9615:CENPK
uniprot id: A0A8C0M286
uniprot id: A0A8I3NB51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

9615:RPL24
gene id: 9615:RPL24
uniprot id: A0A8C0NRA6
uniprot id: A0A8I3PBR3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9615:GLYR1
gene id: 9615:GLYR1
uniprot id: A0A8I3PAM6
uniprot id: A0A8I3S303
uniprot id: A0A8P0SN31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome

9615:HNRNPA2B1
gene id: 9615:HNRNPA2B1
uniprot id: A0A8C0QGK5
uniprot id: A0A8I3NCE9
names: Subcellular Location Annotation
messages: Cytoplasmic granule

9615:RTF2
gene id: 9615:RTF2
uniprot id: A0A8C0SVL2
uniprot id: A0A8I3Q6G3
uniprot id: A0A8P0PBH3
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9615:TCF4
gene id: 9615:TCF4
uniprot id: P15881
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin. Interacts with HIVEP2. Interacts with NEUROD2 (By similarity). Interacts with AGBL1 (By similarity).
messages: Nucleus
messages: Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). Binds to the thyroglobulin promoter.
messages: Widely expressed.

9615:NFKB2
gene id: 9615:NFKB2
uniprot id: A0A8I3PK60
uniprot id: A0A8P0SF42
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:SEC62
gene id: 9615:SEC62
uniprot id: A0A8C0PZV5
uniprot id: A0A8I3PCD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:ACAA1
gene id: 9615:ACAA1
uniprot id: A0A8C0Z0H1
uniprot id: A0A8I3Q466
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9615:STXBP2
gene id: 9615:STXBP2
uniprot id: Q28288
names: Function
names: Similarity
names: Subunit
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Binds syntaxins 1A, 2, 3 but not 4.
messages: Involved in the protein trafficking from the Golgi apparatus to the plasma membrane.

9615:CHPF
gene id: 9615:CHPF
uniprot id: A0A8C0S3G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9615:GLO1
gene id: 9615:GLO1
uniprot id: A0A8C0TFS1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9615:NPVF
gene id: 9615:NPVF
uniprot id: E2QYB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

9615:IFNA5
gene id: 9615:IFNA5
uniprot id: Q75UL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9615:GTF2F2
gene id: 9615:GTF2F2
uniprot id: A0A8C0P9T5
uniprot id: A0A8I3N8L3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9615:FAM135A
gene id: 9615:FAM135A
uniprot id: A0A8C0P3W7
uniprot id: A0A8C0Q6V1
uniprot id: A0A8I3N5X5
uniprot id: A0A8I3NMZ5
names: Similarity
messages: Belongs to the FAM135 family.

9615:RAB13
gene id: 9615:RAB13
uniprot id: F1PTE3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Interacts (GTP-bound form) with MICALL2; competes with RAB8A and is involved in tight junctions assembly. Interacts (GTP-bound form) with MICALL1. Interacts (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1; ternary complexes of RAB8A, RAB13 and either MICAL1 or EHBP1L1 are possible. Interacts with PRKACA; downstream effector of RAB13 involved in tight junction assembly. Interacts with GRB2; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA. Interacts (isoprenylated form) with PDE6D; dissociates RAB13 from membranes. Interacts with BICDL2/BICDR2. Interacts with LEPROT and LEPROTL1.
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). That Rab may be activated by DENND1C, a guanine exchange factor. Activated in response to insulin (By similarity).
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
messages: lamellipodium
messages: tight junction
messages: trans-Golgi network membrane

9615:CDC42SE2
gene id: 9615:CDC42SE2
uniprot id: A0A8C0YUL1
uniprot id: A0A8I3N9L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9615:MRPL42
gene id: 9615:MRPL42
uniprot id: A0A8C0NHB9
uniprot id: A0A8I3S264
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9615:ATP6V1E1
gene id: 9615:ATP6V1E1
uniprot id: A0A8C0T1Z7
uniprot id: A0A8I3QBE3
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9615:PTER
gene id: 9615:PTER
uniprot id: A0A8C0Q3W7
uniprot id: A0A8I3P1X1
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:ACVR2A
gene id: 9615:ACVR2A
uniprot id: A0A8C0Z3E6
uniprot id: A0A8I3MYH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9615:DPH5
gene id: 9615:DPH5
uniprot id: A0A8I3NBJ4
uniprot id: A0A8P0PJS0
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9615:SLC16A12
gene id: 9615:SLC16A12
uniprot id: A0A8C0NVK2
uniprot id: A0A8I3PW22
uniprot id: A0A8I3Q558
names: Subcellular Location Annotation
messages: Membrane

9615:ELMO3
gene id: 9615:ELMO3
uniprot id: A0A8C0T023
uniprot id: A0A8I3N1G7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9615:RPS4X
gene id: 9615:RPS4X
uniprot id: A0A8C0SBE5
uniprot id: A0A8I3PBZ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9615:ARID3C
gene id: 9615:ARID3C
uniprot id: A0A8C0MCN7
uniprot id: A0A8I3PR68
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Transcription factor.

9615:GABRQ
gene id: 9615:GABRQ
uniprot id: A0A8C0SPU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:THRSP
gene id: 9615:THRSP
uniprot id: A0A8C0YXJ3
uniprot id: A0A8I3N8C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9615:MAPRE1
gene id: 9615:MAPRE1
uniprot id: A0A8C0RYJ4
uniprot id: A0A8I3PST2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9615:LOC474850
gene id: 9615:LOC474850
uniprot id: A0A8P0N3U3
uniprot id: A0A8P0N501
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9615:HADHB
gene id: 9615:HADHB
uniprot id: A0A8C0QIR3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9615:DSG3
gene id: 9615:DSG3
uniprot id: Q7YRU7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).
messages: Interacts with PKP2.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
messages: desmosome

9615:NDUFA13
gene id: 9615:NDUFA13
uniprot id: A0A8C0RIQ0
uniprot id: A0A8I3NVS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

9615:HMBS
gene id: 9615:HMBS
uniprot id: A0A8C0TCQ7
uniprot id: A0A8C0TFA4
uniprot id: A0A8I3RP95
names: Similarity
messages: Belongs to the HMBS family.

9615:SP4
gene id: 9615:SP4
uniprot id: A0A8C0Q9H8
uniprot id: A0A8I3N2Z8
names: Subcellular Location Annotation
messages: Nucleus

9615:CPN1
gene id: 9615:CPN1
uniprot id: A0A8P0SEL5
names: Similarity
messages: Belongs to the peptidase M14 family.

9615:S100A8
gene id: 9615:S100A8
uniprot id: A0A8C0PA04
uniprot id: C0LQL0
names: Similarity
messages: Belongs to the S-100 family.

9615:ERLIN1
gene id: 9615:ERLIN1
uniprot id: A0A8C0T3T7
uniprot id: A0A8I3NZK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9615:OPN1LW
gene id: 9615:OPN1LW
uniprot id: O18914
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: The three color pigments are found in the cone photoreceptor cells.
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

9615:ADAM9
gene id: 9615:ADAM9
uniprot id: A0A8C0S078
uniprot id: E1ACC5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:DRD2
gene id: 9615:DRD2
uniprot id: Q9GJU1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:11054572). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).
messages: Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with CADPS and CADPS2 (By similarity). Interacts with GPRASP1, PPP1R9B and CLIC6. Interacts with ARRB2 (By similarity). Interacts with HTR2A (By similarity). Interacts with DRD1. Interacts with KCNA2 (By similarity).
messages: Golgi apparatus membrane
messages: Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8.

9615:FOXB1
gene id: 9615:FOXB1
uniprot id: A0A8C0Z1U7
uniprot id: A0A8I3P1X5
names: Subcellular Location Annotation
messages: Nucleus

9615:SEC24A
gene id: 9615:SEC24A
uniprot id: A0A8C0QG40
uniprot id: A0A8I3NPS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9615:SMPD1
gene id: 9615:SMPD1
uniprot id: A0A8C0MWB3
uniprot id: A0A8I3RTW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

9615:CLDN14
gene id: 9615:CLDN14
uniprot id: A0A8C0T8S3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:OR4D5
gene id: 9615:OR4D5
uniprot id: A0A8P0SQ27
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:TIRAP
gene id: 9615:TIRAP
uniprot id: A0A8I3NN38
uniprot id: A0A8P0SPC8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Membrane

9615:SERPINA12
gene id: 9615:SERPINA12
uniprot id: A0A8I3RSM5
uniprot id: A0A8P0SLL3
names: Similarity
messages: Belongs to the serpin family.

9615:C4BPB
gene id: 9615:C4BPB
uniprot id: A0A8P0NQ13
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:OR7D2
gene id: 9615:OR7D2
uniprot id: A0A8C0Z5Q4
uniprot id: A0A8I3PYA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:RRP7
gene id: 9615:RRP7
uniprot id: A0A8C0YYC0
uniprot id: A0A8I3S121
names: Similarity
messages: Belongs to the RRP7 family.

9615:CYB5R3
gene id: 9615:CYB5R3
uniprot id: Q0X0E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor.
messages: Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MTARC2 (By similarity). Interacts with MTLN; the interaction is required to maintain cellular lipid composition and leads to stimulation of mitochondrial respiratory complex I activity (By similarity).
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9615:EDA
gene id: 9615:EDA
uniprot id: A0A8C0TM26
uniprot id: Q58P77
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9615:HINT1
gene id: 9615:HINT1
uniprot id: A0A8C0RQ83
uniprot id: A0A8I3RVN4
names: Similarity
messages: Belongs to the HINT family.

9615:STARD3
gene id: 9615:STARD3
uniprot id: A0A8C0PT55
uniprot id: A0A8I3NXJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9615:NDRG3
gene id: 9615:NDRG3
uniprot id: A0A8C0SDZ8
uniprot id: A0A8C0SFV1
uniprot id: A0A8I3PXC0
names: Similarity
messages: Belongs to the NDRG family.

9615:DYRK4
gene id: 9615:DYRK4
uniprot id: A0A8I3QBY9
uniprot id: A0A8P0PNM6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9615:SCFD2
gene id: 9615:SCFD2
uniprot id: A0A8I3NJI6
uniprot id: A0A8P0P2R6
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9615:HMGA1
gene id: 9615:HMGA1
uniprot id: Q6URC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMGA family.
messages: Chromosome
messages: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity).
messages: Interacts with HIPK2.
messages: Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation may modulate DNA-binding affinity (By similarity).
messages: Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.
messages: Nucleus

9615:H3C1
gene id: 9615:H3C1
uniprot id: A0A8C0TQX3
uniprot id: J9PB22
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:OR2F1
gene id: 9615:OR2F1
uniprot id: Q95156
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Putative odorant or sperm cell receptor.

9615:NICN1
gene id: 9615:NICN1
uniprot id: Q861Y6
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.

9615:CDH8
gene id: 9615:CDH8
uniprot id: A0A8I3NBY5
uniprot id: A0A8P0SPC1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9615:CATSPERE
gene id: 9615:CATSPERE
uniprot id: A0A8C0NPC1
names: Similarity
messages: Belongs to the CATSPERD family.

9615:CCS
gene id: 9615:CCS
uniprot id: A0A8C0SJL5
uniprot id: A0A8I3NJ97
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9615:ZNF483
gene id: 9615:ZNF483
uniprot id: A0A8P0TDK7
names: Subcellular Location Annotation
messages: Nucleus

9615:KHDRBS2
gene id: 9615:KHDRBS2
uniprot id: A0A8C0MEQ0
uniprot id: A0A8I3N4D2
names: Similarity
messages: Belongs to the KHDRBS family.

9615:CYP1B1
gene id: 9615:CYP1B1
uniprot id: C1KG39
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:ADPRS
gene id: 9615:ADPRS
uniprot id: A0A8C0NSF6
uniprot id: A0A8I3SCV6
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9615:ADRB2
gene id: 9615:ADRB2
uniprot id: P54833
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
messages: Binds NHERF1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC (By similarity). Interacts with USP20 and USP33 (By similarity). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3. Interacts with NEDD4 (By similarity). Interacts with MARCHF2 (By similarity).
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus
messages: Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.
messages: Palmitoylated. Mainly palmitoylated at Cys-341. Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi. Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor. Could be depalmitoylated by LYPLA1 at the plasma membrane.
messages: Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity).
messages: Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
messages: Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
messages: Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent (By similarity).

9615:LOC480667
gene id: 9615:LOC480667
uniprot id: A0A8C0YX74
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9615:AASDH
gene id: 9615:AASDH
uniprot id: A0A8C0RQ56
uniprot id: A0A8I3P014
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:PHC2
gene id: 9615:PHC2
uniprot id: A0A8C0NB60
uniprot id: A0A8C0RK23
uniprot id: A0A8C0Z2B6
names: Subcellular Location Annotation
messages: Nucleus

9615:DDIAS
gene id: 9615:DDIAS
uniprot id: A0A8C0M5T4
names: Similarity
messages: Belongs to the replication factor A protein 1 family.

9615:GNG7
gene id: 9615:GNG7
uniprot id: A0A8C0RFD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:TAF9B
gene id: 9615:TAF9B
uniprot id: A0A8C0Z0L8
uniprot id: A0A8I3P616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9615:INTS7
gene id: 9615:INTS7
uniprot id: A0A8C0RF21
uniprot id: A0A8I3MIC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9615:TBXA2R
gene id: 9615:TBXA2R
uniprot id: A0A8C0QLX5
uniprot id: A0A8I3NCM2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:MAPK14
gene id: 9615:MAPK14
uniprot id: O02812
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases the affinity for ATP and enhances kinase activity. Lys-53 and Lys-152 are deacetylated by HDAC3 (By similarity).
messages: Activated by cell stresses such as DNA damage, heat shock, osmotic shock, anisomycin and sodium arsenite, as well as pro-inflammatory stimuli such as bacterial lipopolysaccharide (LPS) and interleukin-1. Activation occurs through dual phosphorylation of Thr-180 and Tyr-182 by either of two dual specificity kinases, MAP2K3/MKK3 or MAP2K6/MKK6, and potentially also MAP2K4/MKK4, as well as by TAB1-mediated autophosphorylation. MAPK14 phosphorylated on both Thr-180 and Tyr-182 is 10-20-fold more active than MAPK14 phosphorylated only on Thr-180, whereas MAPK14 phosphorylated on Tyr-182 alone is inactive. whereas Thr-180 is necessary for catalysis, Tyr-182 may be required for auto-activation and substrate recognition. Phosphorylated at Tyr-323 by ZAP70 in an alternative activation pathway in response to TCR signaling in T-cells. This alternative pathway is inhibited by GADD45A. Inhibited by dual specificity phosphatases, such as DUSP1, DUSP10, and DUSP16. Specifically inhibited by the binding of pyridinyl-imidazole compounds, which are cytokine-suppressive anti-inflammatory drugs (CSAID). SB203580 is an inhibitor of MAPK14 (By similarity).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (By similarity). Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation (By similarity). Interacts with SPAG9 and GADD45A (By similarity). Interacts with CDC25B, CDC25C, DUSP1, DUSP10, DUSP16, NP60, SUPT20H and TAB1. Interacts with casein kinase II subunits CSNK2A1 and CSNK2B. Interacts with PPM1D. Interacts with CDK5RAP3; recruits PPM1D to MAPK14 and may regulate its dephosphorylation (By similarity). Interacts with DUSP2; this interaction does not lead to catalytic activation of DUSP2 and dephosphrylation of MAPK14 (By similarity).
messages: Cytoplasm
messages: Dually phosphorylated on Thr-180 and Tyr-182 by the MAP2Ks MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. Dual phosphorylation can also be mediated by TAB1-mediated autophosphorylation. TCR engagement in T-cells also leads to Tyr-323 phosphorylation by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP16 (By similarity). PPM1D also mediates dephosphorylation and inactivation of MAPK14 (By similarity).
messages: Nucleus
messages: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulatin…
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
messages: Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway (By similarity).

9615:S1PR2
gene id: 9615:S1PR2
uniprot id: A0A8C0P6J2
uniprot id: A0A8I3P3I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:ZDHHC5
gene id: 9615:ZDHHC5
uniprot id: Q2THW9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated (By similarity). Palmitoylation of the C-terminal tail regulates stimulation-dependent plasma membrane motility (By similarity).
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Cell membrane
messages: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, fatty acid uptake, bacterial sensing or cardiac functions. Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins. Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2. Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2. Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes. Participates also in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane. Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis.
messages: Phosphorylation regulates association with endocytic proteins and its subcellular localization. Phosphorylation by LYN during fatty acid uptake leads to inactivation of the activity.
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:GJB1
gene id: 9615:GJB1
uniprot id: A0A8C0TR63
uniprot id: E2QYR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:LOC489332
gene id: 9615:LOC489332
uniprot id: A0A8I3RYN7
uniprot id: A0A8P0NDC6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SIRT5
gene id: 9615:SIRT5
uniprot id: E2RDZ6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1. Interacts with PCCA (By similarity).
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
messages: Nucleus
messages: cytosol

9615:NUDT1
gene id: 9615:NUDT1
uniprot id: F1P963
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Nucleus membrane
messages: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:30304478, PubMed:32144205, PubMed:29281266). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (By similarity). Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:30304478, PubMed:32144205, PubMed:29281266). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:30304478, PubMed:32144205, PubMed:29281266). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:30304478, PubMed:32144205, PubMed:29281266).
messages: acrosome

9615:SLC34A1
gene id: 9615:SLC34A1
uniprot id: A0A8C0M6W3
uniprot id: A0A8I3NFY6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9615:RSPO2
gene id: 9615:RSPO2
uniprot id: A0A8C0QHB7
names: Similarity
messages: Belongs to the R-spondin family.

9615:SCN10A
gene id: 9615:SCN10A
uniprot id: O46669
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
messages: Cell membrane
messages: Expressed in nodose ganglia, but not in cortex, hippocampus, cerebellum, liver, heart and skeletal muscle.
messages: Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 825) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.
messages: Phosphorylation at Ser-1458 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
messages: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
messages: The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.
messages: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
messages: Ubiquitinated by NEDD4L; which promotes its endocytosis.

9615:TAF5
gene id: 9615:TAF5
uniprot id: A0A8C0PRN2
uniprot id: A0A8I3S680
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9615:SERPINB10
gene id: 9615:SERPINB10
uniprot id: A0A8C0NEC0
uniprot id: A0A8I3MHW7
names: Similarity
messages: Belongs to the serpin family.

9615:TMEM91
gene id: 9615:TMEM91
uniprot id: A0A8C0M128
uniprot id: A0A8I3MF62
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9615:TAF13
gene id: 9615:TAF13
uniprot id: A0A8C0T7V3
uniprot id: E2QZK3
names: Subcellular Location Annotation
messages: Nucleus

9615:CAPN8
gene id: 9615:CAPN8
uniprot id: A0A8P0NHT2
names: Similarity
messages: Belongs to the peptidase C2 family.

9615:FGA
gene id: 9615:FGA
uniprot id: A0A8C0MTI9
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9615:OS9
gene id: 9615:OS9
uniprot id: A0A8C0MI89
uniprot id: A0A8C0RDR8
uniprot id: A0A8I3NEI4
uniprot id: A0A8I3NKE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

9615:ACSM3
gene id: 9615:ACSM3
uniprot id: A0A8I3N6J5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:SLC43A2
gene id: 9615:SLC43A2
uniprot id: A0A8C0NGF8
uniprot id: E2R5V2
names: Subcellular Location Annotation
messages: Membrane

9615:RNF111
gene id: 9615:RNF111
uniprot id: A0A8C0TZ76
uniprot id: A0A8I3RZ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arkadia family.
messages: PML body

9615:EDN3
gene id: 9615:EDN3
uniprot id: Q765Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides.
messages: Expressed in which included heart, lung, liver, kidney, spleen, stomach, pancreas, duodenum, colon, uterus, ovary and testis.
messages: Secreted

9615:CS
gene id: 9615:CS
uniprot id: A0A8C0QGS7
uniprot id: A0A8I3RVM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Homodimer.
messages: Mitochondrion matrix

9615:H2AC15
gene id: 9615:H2AC15
uniprot id: A0A5F4CIE3
uniprot id: A0A8C0NV55
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:PCSK1
gene id: 9615:PCSK1
uniprot id: A0A8C0NKL9
uniprot id: A0A8I3RR59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9615:ETFRF1
gene id: 9615:ETFRF1
uniprot id: A0A8C0THG3
uniprot id: A0A8I3RZQ4
names: Similarity
messages: Belongs to the complex I LYR family.

9615:PNLDC1
gene id: 9615:PNLDC1
uniprot id: A0A8C0TM72
names: Similarity
messages: Belongs to the CAF1 family.

9615:CASP10
gene id: 9615:CASP10
uniprot id: A0A8C0TGH3
uniprot id: A0A8I3SCI1
names: Similarity
messages: Belongs to the peptidase C14A family.

9615:ST3GAL5
gene id: 9615:ST3GAL5
uniprot id: A0A8C0T5R4
uniprot id: A0A8I3NNC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:C7H1orf43
gene id: 9615:C7H1orf43
uniprot id: A0A8P0SLK3
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

9615:CHST3
gene id: 9615:CHST3
uniprot id: A0A8C0PUP3
uniprot id: E2RLE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9615:CPT1A
gene id: 9615:CPT1A
uniprot id: A0A8C0S023
uniprot id: A0A8I3N3L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:CXCR2
gene id: 9615:CXCR2
uniprot id: A0A8C0TK08
uniprot id: A0A8I3PZU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:SLC26A3
gene id: 9615:SLC26A3
uniprot id: A0A8C0P548
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane

9615:OR55B1
gene id: 9615:OR55B1
uniprot id: E2RME2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:EXOC5
gene id: 9615:EXOC5
uniprot id: A0A8C0Q1Y6
uniprot id: A0A8I3PAA1
names: Similarity
messages: Belongs to the SEC10 family.

9615:DMAP1
gene id: 9615:DMAP1
uniprot id: A0A8C0N765
uniprot id: A0A8I3Q216
names: Subcellular Location Annotation
messages: Nucleus

9615:BET1
gene id: 9615:BET1
uniprot id: A0A8C0SAE2
uniprot id: A0A8I3NV66
names: Subcellular Location Annotation
messages: Membrane

9615:TSN
gene id: 9615:TSN
uniprot id: A0A8C0P7P2
uniprot id: A0A8I3PL12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9615:ACOXL
gene id: 9615:ACOXL
uniprot id: A0A8C0NLY9
uniprot id: A0A8I3N9Q9
names: Similarity
messages: Belongs to the acyl-CoA oxidase family.

9615:USP7
gene id: 9615:USP7
uniprot id: A0A8C0Q8T7
uniprot id: A0A8C0RG53
uniprot id: A0A8I3NFM5
names: Similarity
messages: Belongs to the peptidase C19 family.

9615:SUV39H1
gene id: 9615:SUV39H1
uniprot id: A0A8C0NJF8
uniprot id: A0A8I3Q5G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9615:LOC479911
gene id: 9615:LOC479911
uniprot id: A0A8C0SNF4
uniprot id: A0A8I3MJB3
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9615:NKX6-2
gene id: 9615:NKX6-2
uniprot id: A0A8C0TUE3
uniprot id: A0A8I3PNH1
names: Subcellular Location Annotation
messages: Nucleus

9615:DNM1
gene id: 9615:DNM1
uniprot id: B4YUE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Cytoplasm

9615:CCDC39
gene id: 9615:CCDC39
uniprot id: A0A8P0TE27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC39 family.
messages: cilium axoneme

9615:NGDN
gene id: 9615:NGDN
uniprot id: A0A8P0NDM1
names: Subcellular Location Annotation
messages: nucleolus

9615:ZDHHC9
gene id: 9615:ZDHHC9
uniprot id: A0A8C0TA82
uniprot id: A0A8I3QDK9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:HOXB13
gene id: 9615:HOXB13
uniprot id: A0A8C0LWY6
uniprot id: A0A8I3RVJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9615:LOC100686431
gene id: 9615:LOC100686431
uniprot id: A0A8C0QEF0
uniprot id: A0A8I3MAC3
names: Subcellular Location Annotation
messages: Nucleus

9615:LOC489590
gene id: 9615:LOC489590
uniprot id: A0A8C0LY03
uniprot id: A0A8I3NXM3
names: Subcellular Location Annotation
messages: Membrane

9615:TIMM8A
gene id: 9615:TIMM8A
uniprot id: A0A8C0MNZ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9615:CHRNB2
gene id: 9615:CHRNB2
uniprot id: A0A8I3NJ59
uniprot id: A0A8P0SL74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:PBX4
gene id: 9615:PBX4
uniprot id: A0A8P0NF27
uniprot id: A0A8P0NFU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9615:NAGPA
gene id: 9615:NAGPA
uniprot id: A0A8I3NX74
uniprot id: A0A8P0SN51
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:ZC3H14
gene id: 9615:ZC3H14
uniprot id: A0A8C0M0Q8
uniprot id: A0A8C0PUR0
uniprot id: A0A8I3NB66
uniprot id: A0A8I3NFS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZC3H14 family.
messages: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
messages: Nucleus speckle

9615:TOM1L1
gene id: 9615:TOM1L1
uniprot id: A0A8C0N8A7
uniprot id: A0A8I3NW39
uniprot id: A0A8I3RZ41
names: Similarity
messages: Belongs to the TOM1 family.

9615:CGN
gene id: 9615:CGN
uniprot id: A7YH32
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cingulin family.
messages: Deletion of the TJP1/ZO1 interaction motif (ZIM) decreases but does not abolish colocalization with TJP1/ZO1.
messages: Homodimer (By similarity). Interacts with TJP1/ZO1 and SPEF1 (By similarity).
messages: It is uncertain whether Met-1 or Met-7 is the initiator.
messages: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: tight junction

9615:INTS12
gene id: 9615:INTS12
uniprot id: A0A8C0T613
uniprot id: A0A8I3Q4C6
names: Similarity
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

9615:UTP18
gene id: 9615:UTP18
uniprot id: A0A8C0N861
uniprot id: A0A8I3NXV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

9615:UCP1
gene id: 9615:UCP1
uniprot id: Q9GMZ1
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Has no constitutive proton transporter activity and has to be activated by long-chain fatty acids/LCFAs. Inhibited by purine nucleotides. Both purine nucleotides and LCFAs bind the cytosolic side of the transporter and directly compete to activate or inhibit it. Activated by noradrenaline and reactive oxygen species. Despite lacking canonical translational encoding for selenocysteine, a small pool of the protein has been observed to selectively incorporate selenocysteine at 'Cys-256'. Selenocysteine-modified protein is highly sensitive to redox modification and may constitute a pool of protein highly sensitive to activation by elevated levels of reactive oxygen species (ROS).
messages: May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane
messages: Most probably functions as a monomer. Binds one purine nucleotide per monomer. However, has also been suggested to function as a homodimer or a homotetramer. Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity.

9615:CD5L
gene id: 9615:CD5L
uniprot id: W8VYQ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:MMP19
gene id: 9615:MMP19
uniprot id: A0A8C0PZW6
uniprot id: A0A8I3MTX4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9615:ATAD1
gene id: 9615:ATAD1
uniprot id: A0A8C0TRI3
names: Similarity
messages: Belongs to the AAA ATPase family.

9615:SLC30A7
gene id: 9615:SLC30A7
uniprot id: A0A8C0PR71
uniprot id: A0A8I3NMF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9615:PSMB1
gene id: 9615:PSMB1
uniprot id: A0A8C0N5D2
uniprot id: A0A8I3PKH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9615:MT2A
gene id: 9615:MT2A
uniprot id: Q9XST5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Interacts with EOLA1.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

9615:MACROH2A1
gene id: 9615:MACROH2A1
uniprot id: A0A8C0S4U0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9615:TMPO
gene id: 9615:TMPO
uniprot id: A0A8C0NW71
uniprot id: A0A8C0NXK9
uniprot id: A0A8C0P293
uniprot id: A0A8C0PBQ8
uniprot id: A0A8C0RPP2
uniprot id: A0A8I3PQ05
uniprot id: A0A8I3PQM7
uniprot id: A0A8I3PYT6
uniprot id: A0A8I3PZV2
uniprot id: A0A8I3S615
names: Similarity
messages: Belongs to the LEM family.

9615:HSPD1
gene id: 9615:HSPD1
uniprot id: A0A8C0TC09
uniprot id: A0A8I3PXL2
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9615:TEK
gene id: 9615:TEK
uniprot id: A0A8C0MPR3
uniprot id: A0A8I3P3D4
uniprot id: A0A8P0N4V0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:ANO4
gene id: 9615:ANO4
uniprot id: A0A8C0NF66
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:NEUROD4
gene id: 9615:NEUROD4
uniprot id: A0A8C0T0H8
uniprot id: A0A8I3NN90
names: Subcellular Location Annotation
messages: Nucleus

9615:SBF2
gene id: 9615:SBF2
uniprot id: A0A8C0MFP1
uniprot id: A0A8C0RDL8
uniprot id: A0A8I3NTI5
uniprot id: A0A8I3S0Q6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9615:CPNE4
gene id: 9615:CPNE4
uniprot id: A0A8C0MF56
uniprot id: A0A8I3PZN1
names: Similarity
messages: Belongs to the copine family.

9615:PFKFB2
gene id: 9615:PFKFB2
uniprot id: A0A8C0SM64
uniprot id: A0A8C0SNE0
uniprot id: A0A8I3MEI5
uniprot id: A0A8I3MJJ0
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9615:UQCR10
gene id: 9615:UQCR10
uniprot id: A0A8C0P344
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9615:CNGA1
gene id: 9615:CNGA1
uniprot id: Q28279
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily.
messages: Cell membrane
messages: Forms a heterotetramer with CNGB1 in a 3:1 ratio. May also form cyclic nucleotide-activated homotetrameric channels, that are efficiently activated by saturating cGMP, but poorly activated by saturating cAMP compared to the heterotetramer with CNGB1.
messages: Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.
messages: The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits.

9615:PFKFB4
gene id: 9615:PFKFB4
uniprot id: A0A8C0TK93
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9615:BCL7C
gene id: 9615:BCL7C
uniprot id: A0A8C0M694
uniprot id: A0A8I3NZ64
names: Similarity
messages: Belongs to the BCL7 family.

9615:IL13RA1
gene id: 9615:IL13RA1
uniprot id: A0A8C0YXT3
uniprot id: A0A8I3PDX4
names: Subcellular Location Annotation
messages: Membrane

9615:LCK
gene id: 9615:LCK
uniprot id: A0A8C0TE05
uniprot id: A0A8I3NAC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9615:SSR2
gene id: 9615:SSR2
uniprot id: P23438
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with STING1 (By similarity).
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9615:SOD1
gene id: 9615:SOD1
uniprot id: Q8WNN6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer; non-disulfide-linked (By similarity). Heterodimer with SOD1. The heterodimer CCS:SOD1 interacts with SLC31A1; this heterotrimer is Cu(1+)-mediated and its maintenance is regulated through SOD1 activation (By similarity).
messages: Nucleus
messages: Palmitoylation helps nuclear targeting and decreases catalytic activity.
messages: Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.

9615:ST6GALNAC2
gene id: 9615:ST6GALNAC2
uniprot id: A0A8C0Q6J7
uniprot id: Q00M94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:KCNK7
gene id: 9615:KCNK7
uniprot id: A0A8I3P863
uniprot id: A0A8P0NFG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9615:CLPTM1
gene id: 9615:CLPTM1
uniprot id: A0A8C0RAV7
uniprot id: A0A8I3MSH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9615:PIGN
gene id: 9615:PIGN
uniprot id: A0A8P0N3B3
uniprot id: A0A8P0P796
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

9615:HAUS3
gene id: 9615:HAUS3
uniprot id: A0A8C0RYK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

9615:POLR2D
gene id: 9615:POLR2D
uniprot id: A0A8C0T6R7
uniprot id: A0A8I3P8V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

9615:SMAD9
gene id: 9615:SMAD9
uniprot id: A0A8C0NHE6
uniprot id: A0A8I3PZR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9615:SKP1
gene id: 9615:SKP1
uniprot id: A0A8C0QKG1
uniprot id: A0A8I3NPT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.
messages: The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.

9615:EIF3G
gene id: 9615:EIF3G
uniprot id: A0A8C0TEQ5
uniprot id: A0A8I3P751
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9615:LOC100684058
gene id: 9615:LOC100684058
uniprot id: A0A8C0SUQ2
uniprot id: A0A8I3P164
names: Similarity
messages: Belongs to the peptidase M67C family.

9615:BCHE
gene id: 9615:BCHE
uniprot id: A0A8C0NAH8
uniprot id: A0A8I3PBA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9615:TSC22D1
gene id: 9615:TSC22D1
uniprot id: A0A8C0P8U6
uniprot id: A0A8I3N3H3
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9615:IFIH1
gene id: 9615:IFIH1
uniprot id: A0A8P0NCH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9615:POLR1C
gene id: 9615:POLR1C
uniprot id: A0A8C0QML3
uniprot id: A0A8I3RVA8
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9615:PYCARD
gene id: 9615:PYCARD
uniprot id: A0A8C0S8E3
uniprot id: A0A8I3RYZ8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

9615:NLGN1
gene id: 9615:NLGN1
uniprot id: A0A8C0PCC8
uniprot id: A0A8I3RYP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9615:SLC25A18
gene id: 9615:SLC25A18
uniprot id: A0A8P0SKP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:LOC474642
gene id: 9615:LOC474642
uniprot id: A0A8C0M819
uniprot id: A0A8I3NFV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:TLR10
gene id: 9615:TLR10
uniprot id: A0A8C0PJX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9615:KRT222
gene id: 9615:KRT222
uniprot id: A0A8C0RLG6
names: Similarity
messages: Belongs to the intermediate filament family.

9615:SSR1
gene id: 9615:SSR1
uniprot id: P16967
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins (By similarity).
messages: Phosphorylated in its cytoplasmic tail.
messages: Seems to bind calcium.
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9615:SIX2
gene id: 9615:SIX2
uniprot id: A0A8C0QI40
uniprot id: A0A8I3Q0I4
names: Subcellular Location Annotation
messages: Nucleus

9615:RPL7A
gene id: 9615:RPL7A
uniprot id: A0A8C0R9V4
uniprot id: A0A8I3NP99
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

9615:LOC106557449
gene id: 9615:LOC106557449
uniprot id: A0A8I3MYF9
uniprot id: A0A8P0TRP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9615:PACC1
gene id: 9615:PACC1
uniprot id: A0A8C0PXB7
uniprot id: A0A8I3RRK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9615:GAD2
gene id: 9615:GAD2
uniprot id: Q4PRC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the production of GABA.
messages: Cytoplasmic vesicle
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Palmitoylated; which is required for presynaptic clustering.
messages: Phosphorylated; which does not affect kinetic parameters or subcellular location.
messages: Presynaptic cell membrane
messages: cytosol

9615:LIMK2
gene id: 9615:LIMK2
uniprot id: A0A8C0RN34
uniprot id: A0A8C0TMY9
uniprot id: A0A8I3S5T7
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9615:MTX2
gene id: 9615:MTX2
uniprot id: A0A8C0RPQ8
uniprot id: A0A8I3NYI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:LYG2
gene id: 9615:LYG2
uniprot id: A0A8C0SRZ9
uniprot id: A0A8I3P4K9
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9615:JAK3
gene id: 9615:JAK3
uniprot id: A0A8P0NSD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system

9615:NLRP3
gene id: 9615:NLRP3
uniprot id: A0A8C0M351
uniprot id: A0A8C0SSV5
uniprot id: A0A8C0YZB5
uniprot id: A0A8I3NW69
uniprot id: A0A8I3P020
uniprot id: A0A8I3PDL7
names: Similarity
messages: Belongs to the NLRP family.

9615:PTPN2
gene id: 9615:PTPN2
uniprot id: A0A8C0M884
uniprot id: A0A8I3MYK9
uniprot id: A0A8I3MZ64
uniprot id: A0A8P0PIC4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9615:AARS1
gene id: 9615:AARS1
uniprot id: A0A8C0SNH1
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9615:PRDM1
gene id: 9615:PRDM1
uniprot id: A0A8P0NZY7
uniprot id: A0A8P0S9C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9615:NSDHL
gene id: 9615:NSDHL
uniprot id: A0A8C0P518
uniprot id: A0A8I3PAN9
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9615:NSG2
gene id: 9615:NSG2
uniprot id: A0A8C0Z1S9
uniprot id: A0A8I3MHX1
names: Similarity
messages: Belongs to the NSG family.

9615:RPRD1B
gene id: 9615:RPRD1B
uniprot id: A0A8C0M4V5
uniprot id: A0A8I3SBP4
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9615:ZBED5
gene id: 9615:ZBED5
uniprot id: A4Z944
names: Miscellaneous
messages: May be derived from an ancient transposon that has lost its ability to translocate.

9615:OR7G3
gene id: 9615:OR7G3
uniprot id: A0A8P0PDH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:AP3D1
gene id: 9615:AP3D1
uniprot id: A0A8C0N252
uniprot id: A0A8I3NYV5
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9615:EGR2
gene id: 9615:EGR2
uniprot id: A0A8C0MVC3
uniprot id: A0A8I3MBA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9615:CHIA
gene id: 9615:CHIA
uniprot id: A0A8C0SEX3
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9615:OR6C69
gene id: 9615:OR6C69
uniprot id: A0A8C0RNK9
uniprot id: A0A8I3SCI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:MAP7D1
gene id: 9615:MAP7D1
uniprot id: A0A8I3Q5K7
uniprot id: A0A8P0NNC7
names: Similarity
messages: Belongs to the MAP7 family.

9615:RBM8A
gene id: 9615:RBM8A
uniprot id: A0A8C0MAY3
uniprot id: A0A8I3NI72
uniprot id: A0A8P0TTV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9615:PLA2G15
gene id: 9615:PLA2G15
uniprot id: Q6XPZ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:11790796). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:11790796). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines. Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (By similarity). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (By similarity). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress. Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (By similarity). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity).
messages: Lysosome
messages: Membrane
messages: N-glycosylated. N-glycosylation is important for maturation of the enzyme and normal subcellular location.
messages: Secreted

9615:SLC25A32
gene id: 9615:SLC25A32
uniprot id: A0A8C0Q9B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:RIPPLY1
gene id: 9615:RIPPLY1
uniprot id: A0A8I3P1S0
uniprot id: A0A8P0SRF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9615:HDAC1
gene id: 9615:HDAC1
uniprot id: A0A8C0NQ85
uniprot id: A0A8I3MVP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
messages: Nucleus

9615:C8B
gene id: 9615:C8B
uniprot id: A0A8C0LYP7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:CCNB1
gene id: 9615:CCNB1
uniprot id: A0A8C0M337
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.

9615:CHRNA7
gene id: 9615:CHRNA7
uniprot id: A0A8P0NCK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:RPL10A
gene id: 9615:RPL10A
uniprot id: A0A8C0SRI0
uniprot id: A0A8I3MZL8
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9615:WTAP
gene id: 9615:WTAP
uniprot id: A0A8C0RJM3
uniprot id: A0A8C0TN68
uniprot id: A0A8I3MIW9
uniprot id: A0A8I3N018
names: Similarity
messages: Belongs to the fl(2)d family.

9615:TRPM4
gene id: 9615:TRPM4
uniprot id: A0A8C0NQ48
names: Subcellular Location Annotation
messages: Membrane

9615:RPS26
gene id: 9615:RPS26
uniprot id: A0A8C0Q8H3
uniprot id: A0A8I3ND98
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9615:GRK5
gene id: 9615:GRK5
uniprot id: A0A8C0TTL8
uniprot id: A0A8I3RZ73
uniprot id: A0A8P0SZL5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9615:ASIC2
gene id: 9615:ASIC2
uniprot id: A0A8C0SC49
uniprot id: A0A8C0SCD1
uniprot id: A0A8I3NDS2
uniprot id: A0A8I3NHZ8
names: Subcellular Location Annotation
messages: Membrane

9615:GPC5
gene id: 9615:GPC5
uniprot id: A0A8C0NJF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9615:HSP70
gene id: 9615:HSP70
uniprot id: Q7YQC6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with TRIM5 (via B30.2/SPRY domain). Interacts with PRKN. Interacts with FOXP3. Interacts with DNAJC9 (via J domain). Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non-acetylated form interact with HOPX and STUB1 respectively. Interacts with NEDD1 and SMAD3. Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105. Interacts with DNAJC8.
messages: Cytoplasm
messages: In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress.
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein re…
messages: Nucleus
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
messages: centrosome

9615:MS4A1
gene id: 9615:MS4A1
uniprot id: Q3C2E2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.
messages: Belongs to the MS4A family.
messages: Cell membrane
messages: Expressed in PBMCs and lymph node from healthy dogs, in B-cells of canine lymphoma, but not in T-cell lymphoma cells and non-T and non-B-cell lymphoma cells.
messages: Forms homotetramers. Interacts with the heavy and light chains of cell surface IgM, the antigen-binding components of the BCR.
messages: Phosphorylated. Might be functionally regulated by protein kinase(s) (By similarity).

9615:PDGFRL
gene id: 9615:PDGFRL
uniprot id: A0A8C0QHQ6
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

9615:ZSCAN22
gene id: 9615:ZSCAN22
uniprot id: A0A8C0PZ81
names: Subcellular Location Annotation
messages: Nucleus

9615:UBA7
gene id: 9615:UBA7
uniprot id: A0A8C0NL23
uniprot id: A0A8I3Q3R3
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9615:SEPTIN3
gene id: 9615:SEPTIN3
uniprot id: A0A8C0PBI8
uniprot id: A0A8C0PMN8
uniprot id: A0A8I3NS66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9615:RPL10L
gene id: 9615:RPL10L
uniprot id: A0A8C0LZJ8
uniprot id: A0A8I3MKJ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9615:CRX
gene id: 9615:CRX
uniprot id: Q8SQ03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Interacts (via the homeobox) with NRL (via the leucine-zipper domain). Interacts with PDC, RAX2, RORB and SCA7 (By similarity).
messages: Nucleus
messages: Retina.
messages: Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors (By similarity).

9615:SCFD1
gene id: 9615:SCFD1
uniprot id: A0A8C0MVI7
uniprot id: A0A8C0N0I1
uniprot id: A0A8I3NFJ9
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9615:CFH
gene id: 9615:CFH
uniprot id: A0A8C0S2A6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:RPL3
gene id: 9615:RPL3
uniprot id: A0A8C0Q751
uniprot id: A0A8I3PMB8
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9615:LYZ
gene id: 9615:LYZ
uniprot id: G1K265
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9615:INTU
gene id: 9615:INTU
uniprot id: A0A8C0MMI7
uniprot id: A0A8I3P133
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inturned family.
messages: Cell surface
messages: cilium basal body

9615:HMGN4
gene id: 9615:HMGN4
uniprot id: A0A8C0QRY7
uniprot id: A0A8I3NZG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9615:IL33
gene id: 9615:IL33
uniprot id: O97863
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity).
messages: Cytoplasm
messages: Expressed in cultured umbilical artery smooth muscle cells after stimulation with IL1A and IL1B, and to a lesser extent with IFNG. Expressed in vasospastic cerebral arteries after subarachnoid hemorrhage.
messages: Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
messages: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro-inflammatory activation (By similarity).
messages: Nucleus
messages: Secreted
messages: The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CELA1, CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full-length protein. May also be proteolytically processed by calpains. Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation. In vitro proteolytic cleavage by CASP1 was reported but could not be confirmed in vivo suggesting that IL33 is probably not a direct substrate for that caspase (By similarity).
messages: The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association.
messages: secretory vesicle

9615:ANO10
gene id: 9615:ANO10
uniprot id: A0A8C0P8I2
uniprot id: A0A8C0Q316
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:ANXA7
gene id: 9615:ANXA7
uniprot id: A0A8C0PPV8
uniprot id: A0A8C0PQ22
uniprot id: A0A8I3MVW5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9615:SH3RF2
gene id: 9615:SH3RF2
uniprot id: A0A8C0QI77
uniprot id: A0A8I3P555
uniprot id: A0A8P0SBT7
names: Similarity
messages: Belongs to the SH3RF family.

9615:DARS2
gene id: 9615:DARS2
uniprot id: A0A8C0LWD8
uniprot id: A0A8C0M1N0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

9615:RAPSN
gene id: 9615:RAPSN
uniprot id: A0A8C0QM89
names: Similarity
messages: Belongs to the RAPsyn family.

9615:CLN5
gene id: 9615:CLN5
uniprot id: Q5JZQ9
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLN5 family.
messages: Can undergo proteolytic cleavage at the C-terminus, probably by a cysteine protease and may involve the removal of approximately 10-15 residues from the C-terminal end.
messages: Defects in CLN5 are the cause of neuronal ceroid lipofuscinosis (NCL). NCL is characterized by brain atrophy and the accumulation of lysosome derived fluorescent storage bodies in neurons and most other cells. NCL is found in Border collie dogs.
messages: Interacts with SORT1, RAB5A and RAB7A. Interacts with PPT1, TPP1, CLN3, CLN6, CLN8, ATP5F1A and ATP5F1B.
messages: Lysosome
messages: Membrane
messages: N-glycosylated with both high mannose and complex type sugars. Glycosylation is important for proper folding and trafficking to the lysosomes.
messages: Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.
messages: The type II membrane signal anchor is proteolytically cleaved to produce a mature form that is transported to the lysosomes (Ceroid-lipofuscinosis neuronal protein 5, secreted form).

9615:NUDT7
gene id: 9615:NUDT7
uniprot id: A0A8C0M0L4
uniprot id: A0A8I3PAK1
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

9615:BEST2
gene id: 9615:BEST2
uniprot id: A0A8C0NUH7
uniprot id: A0A8I3RZ58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9615:RPS6KB2
gene id: 9615:RPS6KB2
uniprot id: A0A8C0P2H0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9615:ACTR10
gene id: 9615:ACTR10
uniprot id: A0A8C0RWH2
uniprot id: A0A8I3NZT5
names: Similarity
messages: Belongs to the actin family.

9615:BIRC3
gene id: 9615:BIRC3
uniprot id: A1E2V0
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Interacts with PRSS25; the interaction inhibits apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interaction with TRAF2 is required for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B. Interacts with RIP1, RIP2, RIP3, RIP4 and USP19.
messages: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
messages: Nucleus
messages: USP19 regulates the stability of BIRC3/c-IAP2 by preventing its ubiquitination.

9615:TFE3
gene id: 9615:TFE3
uniprot id: A0A8C0S7Y9
uniprot id: A0A8I3S7X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9615:SLC25A1
gene id: 9615:SLC25A1
uniprot id: A0A8C0P467
uniprot id: A0A8I3Q9J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:CTSE
gene id: 9615:CTSE
uniprot id: A0A8C0MNS6
uniprot id: A0A8C0T3R3
uniprot id: A0A8I3PVL6
uniprot id: A0A8I3SB35
names: Similarity
messages: Belongs to the peptidase A1 family.

9615:HLCS
gene id: 9615:HLCS
uniprot id: A0A8C0PY04
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9615:PCDHA13
gene id: 9615:PCDHA13
uniprot id: A0A8P0PLR4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9615:TTC30A
gene id: 9615:TTC30A
uniprot id: A0A8C0SZC0
uniprot id: A0A8I3PCE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9615:CAMP
gene id: 9615:CAMP
uniprot id: A0A8C0TPA0
uniprot id: Q6TN20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9615:HAMP
gene id: 9615:HAMP
uniprot id: Q5U9D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hepcidin family.
messages: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.
messages: Interacts with SLC40A1; this interaction promotes SLC40A1 rapid ubiquitination.
messages: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
messages: Secreted

9615:COQ5
gene id: 9615:COQ5
uniprot id: A0A8C0P8S8
uniprot id: A0A8I3Q1K8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9615:GFUS
gene id: 9615:GFUS
uniprot id: A0A8C0PE64
uniprot id: A0A8I3P1I1
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9615:ASIC5
gene id: 9615:ASIC5
uniprot id: A0A8I3RW06
uniprot id: A0A8P0NAZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9615:CHRNA9
gene id: 9615:CHRNA9
uniprot id: A0A8I3RTA8
uniprot id: A0A8P0SK06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:TOMM22
gene id: 9615:TOMM22
uniprot id: A0A8C0NK70
uniprot id: A0A8I3S6N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9615:MPP7
gene id: 9615:MPP7
uniprot id: A0A8C0MPG3
uniprot id: A0A8C0MYQ1
uniprot id: A0A8I3N9S4
uniprot id: A0A8I3NH36
uniprot id: A0A8I3RZ13
uniprot id: A0A8P0TUP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: adherens junction
messages: tight junction

9615:SLCO3A1
gene id: 9615:SLCO3A1
uniprot id: A0A8C0M7K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9615:MAST2
gene id: 9615:MAST2
uniprot id: A0A8I3P992
uniprot id: A0A8I3PEK0
uniprot id: A0A8P0PCY4
uniprot id: A0A8P0SSQ4
uniprot id: A0A8P0T262
uniprot id: A0A8P0TD56
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9615:DCLK1
gene id: 9615:DCLK1
uniprot id: A0A8C0S8G2
uniprot id: A0A8I3QHP2
uniprot id: A0A8I3QQX4
uniprot id: A0A8P0SBN0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9615:IFT57
gene id: 9615:IFT57
uniprot id: A0A8I3S4R3
uniprot id: A0A8P0NC21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9615:FGF6
gene id: 9615:FGF6
uniprot id: A0A8C0TKR8
uniprot id: E2REX2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:SLC6A19
gene id: 9615:SLC6A19
uniprot id: A0A8C0MTV1
uniprot id: A0A8I3S5V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9615:NKX2-5
gene id: 9615:NKX2-5
uniprot id: A0A8C0LX42
uniprot id: Q5J2F2
names: Subcellular Location Annotation
messages: Nucleus

9615:CDK14
gene id: 9615:CDK14
uniprot id: A0A8C0SUP7
uniprot id: A0A8I3NJK4
uniprot id: A0A8I3NKI6
uniprot id: A0A8P0PSM6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:CUL7
gene id: 9615:CUL7
uniprot id: A0A8P0N4X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9615:HIGD1B
gene id: 9615:HIGD1B
uniprot id: A0A8C0M3H0
uniprot id: A0A8C0SJJ0
uniprot id: A0A8I3RTR9
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9615:PPP1R12A
gene id: 9615:PPP1R12A
uniprot id: A0A8C0PET9
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9615:OR11H6
gene id: 9615:OR11H6
uniprot id: A0A8I3PLN1
uniprot id: A0A8P0SPU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:LOC478038
gene id: 9615:LOC478038
uniprot id: A0A8C0LXU7
uniprot id: A0A8C0Q0C0
uniprot id: A0A8C0Q0S5
uniprot id: A0A8C0Q441
uniprot id: A0A8C0Q4Z1
uniprot id: A0A8C0Q556
uniprot id: A0A8C0Q8C7
uniprot id: A0A8I3MNK1
uniprot id: A0A8I3MV26
uniprot id: A0A8I3RSS3
uniprot id: A0A8P0P3N8
uniprot id: A0A8P0P9G1
uniprot id: A0A8P0TT22
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9615:PTPN1
gene id: 9615:PTPN1
uniprot id: A0A8C0YVM6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9615:ZDHHC13
gene id: 9615:ZDHHC13
uniprot id: A0A8C0P7Z1
uniprot id: A0A8I3P1B7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:SMC1B
gene id: 9615:SMC1B
uniprot id: A0A8C0MIN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9615:OPN1SW
gene id: 9615:OPN1SW
uniprot id: A0A8C0PGR1
uniprot id: A0A8I3PJU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9615:SCNN1D
gene id: 9615:SCNN1D
uniprot id: A0A8C0PXI2
names: Subcellular Location Annotation
messages: Membrane

9615:HTR1F
gene id: 9615:HTR1F
uniprot id: A0A8I3S5I1
uniprot id: A0A8P0NA47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

9615:GCLC
gene id: 9615:GCLC
uniprot id: A0A8P0N5C9
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

9615:TUBB1
gene id: 9615:TUBB1
uniprot id: A0A8C0T7N2
uniprot id: A0A8I3NIF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:NKIRAS1
gene id: 9615:NKIRAS1
uniprot id: A0A8C0TKR2
uniprot id: A0A8I3NZV3
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9615:RAB25
gene id: 9615:RAB25
uniprot id: E2RQ15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer. Interacts with VPS33B (By similarity).
messages: Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).
messages: pseudopodium membrane

9615:OR6AA7
gene id: 9615:OR6AA7
uniprot id: A0A8C0SR16
uniprot id: A0A8I3NWT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:OR6N2
gene id: 9615:OR6N2
uniprot id: G3FJD3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:DPP7
gene id: 9615:DPP7
uniprot id: A0A8I3PJI1
uniprot id: A0A8P0SND9
names: Similarity
messages: Belongs to the peptidase S28 family.

9615:ABRAXAS1
gene id: 9615:ABRAXAS1
uniprot id: A0A8C0Z6D0
uniprot id: A0A8I3PGI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Nucleus

9615:GDPD1
gene id: 9615:GDPD1
uniprot id: A0A8C0Q406
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9615:FGFBP1
gene id: 9615:FGFBP1
uniprot id: A0A8P0SJZ4
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9615:CHST11
gene id: 9615:CHST11
uniprot id: A0A8I3MZ05
uniprot id: A0A8P0TBX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:DNAJC10
gene id: 9615:DNAJC10
uniprot id: A0A8P0SIS7
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.
messages: Endoplasmic reticulum lumen

9615:NF2
gene id: 9615:NF2
uniprot id: A0A8C0PQF1
uniprot id: A0A8C0PR45
uniprot id: A0A8I3Q577
uniprot id: A0A8I3QBP5
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9615:SLC39A9
gene id: 9615:SLC39A9
uniprot id: A0A8C0NKD5
uniprot id: A0A8I3MSN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: perinuclear region
messages: trans-Golgi network membrane

9615:C5AR1
gene id: 9615:C5AR1
uniprot id: P30992
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Homodimer. May also form higher-order oligomers. Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR.
messages: Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to C5a.
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1472004). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).
messages: Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.

9615:TNFAIP1
gene id: 9615:TNFAIP1
uniprot id: A0A8C0T9F1
uniprot id: A0A8I3NFW8
names: Similarity
messages: Belongs to the BACURD family.

9615:AQP3
gene id: 9615:AQP3
uniprot id: A0A8P0N4Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9615:H1-4
gene id: 9615:H1-4
uniprot id: A0A8C0TUV9
uniprot id: A0A8I3PW81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9615:UPF1
gene id: 9615:UPF1
uniprot id: A0A8C0RKR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

9615:RPLP0
gene id: 9615:RPLP0
uniprot id: A0A8C0T9H8
uniprot id: A0A8I3QJZ3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9615:SEMA4D
gene id: 9615:SEMA4D
uniprot id: A0A8P0NZW3
uniprot id: A0A8P0PAW9
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:RRP1
gene id: 9615:RRP1
uniprot id: A0A8C0SI49
names: Similarity
messages: Belongs to the RRP1 family.

9615:RARS1
gene id: 9615:RARS1
uniprot id: A0A8C0Q2E6
uniprot id: A0A8I3RSP3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:IL29L
gene id: 9615:IL29L
uniprot id: Q1JUL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9615:LOC119863920
gene id: 9615:LOC119863920
uniprot id: A0A8C0P4Q8
uniprot id: A0A8I3MM72
names: Subcellular Location Annotation
messages: Nucleus

9615:SPTLC3
gene id: 9615:SPTLC3
uniprot id: A0A8I3PMG7
uniprot id: A0A8P0PNN3
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9615:USP44
gene id: 9615:USP44
uniprot id: A0A8C0Q8Z5
uniprot id: A0A8I3PX43
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9615:IFT43
gene id: 9615:IFT43
uniprot id: A0A8C0NE90
uniprot id: A0A8I3NMQ1
names: Similarity
messages: Belongs to the IFT43 family.

9615:GCG
gene id: 9615:GCG
uniprot id: P29794
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glucagon family.
messages: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain.
messages: Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion (By similarity).
messages: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
messages: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
messages: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6. Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis.
messages: Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas (By similarity).
messages: Secreted
messages: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.
messages: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.

9615:PRKACA
gene id: 9615:PRKACA
uniprot id: Q8MJ44
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2. Activates cAMP-sensitive PKAI and PKAII holoenzymes by interacting with regulatory subunit (R) of PKA, PRKAR1A/PKR1 and PRKAR2A/PKR2, respectively. Interacts with NFKB1, NFKB2 and NFKBIA in platelets; these interactions are disrupted by thrombin and collagen. Binds to ABL1 in spermatozoa and with CDC25B in oocytes (By similarity). Interacts with APOBEC3G and AICDA (By similarity). Interacts with RAB13; downstream effector of RAB13 involved in tight junction assembly. Found in a complex at least composed of MROH2B, PRKACA and TCP11 (By similarity). Interacts with MROH2B (By similarity). Interacts with HSF1 (By similarity). Interacts with TCP11 (By similarity). Interacts with TBC1D31; in the regulation of OFD1 (By similarity). Interacts in free form with SMO (via C-terminus); the interaction leads to sequestration of PRKACA at the membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors (By similarity).
messages: Allosterically activated by various compounds, including ATP. Activated by cAMP; the nucleotide acts as a dynamic and allosteric activator by coupling the two lobes of apo PKA, enhancing the enzyme dynamics synchronously and priming it for catalysis.
messages: Asn-3 is partially deaminated to Asp-3 giving rise to 2 major isoelectric variants, called CB and CA respectively.
messages: Autophosphorylated. Phosphorylation is enhanced by vitamin K(2). Phosphorylated on threonine and serine residues. Phosphorylation on Thr-197 is required for full activity (By similarity). Phosphorylated at Tyr-330 by activated receptor tyrosine kinases EGFR and PDGFR; this increases catalytic efficiency (By similarity).
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylates a large number of substrates in the cytoplasm and the nucleus (By similarity). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (By similarity). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (By similarity). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involve…
messages: Ubiquitously expressed in mammalian tissues.
messages: When myristoylated, Ser-10 is autophosphorylated probably in conjunction with deamidation of Asn-3.

9615:CIAO3
gene id: 9615:CIAO3
uniprot id: A0A8C0NA02
names: Similarity
messages: Belongs to the NARF family.

9615:SSU72
gene id: 9615:SSU72
uniprot id: A0A8C0PZW1
uniprot id: A0A8I3NWC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

9615:ARMT1
gene id: 9615:ARMT1
uniprot id: A0A8C0SV58
uniprot id: A0A8I3MER2
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9615:IGF2BP3
gene id: 9615:IGF2BP3
uniprot id: A0A8C0QDI8
uniprot id: A0A8I3NBD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9615:PGS1
gene id: 9615:PGS1
uniprot id: A0A8C0RB91
uniprot id: A0A8I3NU32
uniprot id: A0A8I3NU67
uniprot id: A0A8P0SAX0
uniprot id: A0A8P0T2S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

9615:ARSA
gene id: 9615:ARSA
uniprot id: Q32KI5
names: Similarity
messages: Belongs to the sulfatase family.

9615:INSM2
gene id: 9615:INSM2
uniprot id: A0A8C0MEL2
names: Subcellular Location Annotation
messages: Nucleus

9615:GPX5
gene id: 9615:GPX5
uniprot id: O46607
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glutathione peroxidase family.
messages: Epididymis.
messages: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
messages: Secreted

9615:HAX1
gene id: 9615:HAX1
uniprot id: A0A8P0SLG6
names: Function
names: Similarity
messages: Belongs to the HAX1 family.
messages: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

9615:POLR3K
gene id: 9615:POLR3K
uniprot id: A0A8C0RM35
uniprot id: A0A8I3RPT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9615:RAD23B
gene id: 9615:RAD23B
uniprot id: A0A8C0NDB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9615:RIOK2
gene id: 9615:RIOK2
uniprot id: A0A8C0SRR6
uniprot id: A0A8I3RQM4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9615:TAF7
gene id: 9615:TAF7
uniprot id: A0A8C0R966
uniprot id: A0A8I3MP84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9615:TSR3
gene id: 9615:TSR3
uniprot id: A0A8C0Q020
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:FMO2
gene id: 9615:FMO2
uniprot id: A0A8C0PJD9
uniprot id: A0A8I3RPX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:KIF24
gene id: 9615:KIF24
uniprot id: A0A8C0QEZ5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:CRY1
gene id: 9615:CRY1
uniprot id: A0A8C0QG30
uniprot id: A0A8I3NL13
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

9615:NAP1L2
gene id: 9615:NAP1L2
uniprot id: A0A8C0SHX1
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9615:SLC25A28
gene id: 9615:SLC25A28
uniprot id: A0A8C0TZR9
uniprot id: A0A8I3Q7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:RPS5
gene id: 9615:RPS5
uniprot id: A0A8C0LSD9
uniprot id: A0A8I3MC30
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9615:MRPL54
gene id: 9615:MRPL54
uniprot id: A0A8C0M9D7
uniprot id: A0A8I3MWS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9615:SLX1A
gene id: 9615:SLX1A
uniprot id: A0A8C0LY20
uniprot id: A0A8I3MM76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
messages: Forms a heterodimer with SLX4.
messages: Nucleus

9615:RAD23A
gene id: 9615:RAD23A
uniprot id: A0A8C0NPF5
uniprot id: A0A8I3NT37
uniprot id: A0A8P0SL62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9615:AMZ1
gene id: 9615:AMZ1
uniprot id: A0A8C0TBA2
uniprot id: A0A8I3NM81
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9615:SLC9A5
gene id: 9615:SLC9A5
uniprot id: A0A8C0MLN6
uniprot id: A0A8I3RUZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane
messages: Recycling endosome membrane

9615:DHX9
gene id: 9615:DHX9
uniprot id: A0A8C0M1F0
uniprot id: A0A8I3RTG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9615:NPNT
gene id: 9615:NPNT
uniprot id: A0A8C0PEW3
uniprot id: A0A8C0PEX3
uniprot id: A0A8C0PFG6
uniprot id: A0A8I3Q0H8
uniprot id: A0A8I3QG70
uniprot id: A0A8I3SBG5
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:AWAT2
gene id: 9615:AWAT2
uniprot id: A0A8I3Q6K5
uniprot id: A0A8P0NHY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9615:KCNJ16
gene id: 9615:KCNJ16
uniprot id: A0A8C0M1I9
uniprot id: E0WCW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9615:FOXJ2
gene id: 9615:FOXJ2
uniprot id: A0A8C0P4Z5
uniprot id: A0A8I3Q4X7
names: Subcellular Location Annotation
messages: Nucleus

9615:HSBP1
gene id: 9615:HSBP1
uniprot id: A0A8C0LW68
uniprot id: A0A8I3NR49
names: Similarity
messages: Belongs to the HSBP1 family.

9615:CENPA
gene id: 9615:CENPA
uniprot id: A0A8I3Q063
uniprot id: A0A8P0N765
names: Similarity
messages: Belongs to the histone H3 family.

9615:MRPL23
gene id: 9615:MRPL23
uniprot id: A0A8I3NG61
uniprot id: A0A8P0NC51
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9615:GPR161
gene id: 9615:GPR161
uniprot id: A0A8I3MK70
uniprot id: A0A8P0TJQ0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:GAL3ST4
gene id: 9615:GAL3ST4
uniprot id: A0A8C0STW4
uniprot id: A0A8I3MFA9
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9615:MAGOHB
gene id: 9615:MAGOHB
uniprot id: A0A8C0SE21
uniprot id: A0A8I3PR32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9615:JUN
gene id: 9615:JUN
uniprot id: A0A8C0Z0Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9615:CPB2
gene id: 9615:CPB2
uniprot id: A0A8C0SRM1
uniprot id: A0A8I3RUJ7
names: Similarity
messages: Belongs to the peptidase M14 family.

9615:MFSD3
gene id: 9615:MFSD3
uniprot id: A0A8C0Z348
uniprot id: A0A8I3NUP5
names: Subcellular Location Annotation
messages: Membrane

9615:ACKR3
gene id: 9615:ACKR3
uniprot id: P11613
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Cell membrane
messages: Early endosome
messages: Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2.
messages: Recycling endosome
messages: The C-terminal cytoplasmic tail, plays a key role in: correct trafficking to the cell membrane, recruitment of beta-arrestin, ubiquitination, and in chemokine scavenging and signaling functions. The Ser/Thr residues and the Lys residues in the C-terminal cytoplasmic tail are essential for beta-arrestin recruitment and ubiquitination respectively.
messages: The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.
messages: Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner.

9615:ADGRE3
gene id: 9615:ADGRE3
uniprot id: Q2Q420
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:INPP5J
gene id: 9615:INPP5J
uniprot id: A0A8C0TL98
uniprot id: A0A8I3S2X3
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9615:ALOXE3
gene id: 9615:ALOXE3
uniprot id: A0A8C0NZG2
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CDCA8
gene id: 9615:CDCA8
uniprot id: A0A8C0QD51
uniprot id: A0A8I3QB13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

9615:CFAP91
gene id: 9615:CFAP91
uniprot id: A0A8C0MS99
uniprot id: A0A8P0P706
names: Similarity
messages: Belongs to the CFAP91 family.

9615:PSMA2
gene id: 9615:PSMA2
uniprot id: A0A8C0QRK5
uniprot id: A0A8I3PCE5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9615:MMP13
gene id: 9615:MMP13
uniprot id: A0A8C0Z2W1
uniprot id: A0A8I3MWY2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9615:SPNS1
gene id: 9615:SPNS1
uniprot id: A0A8C0RSU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9615:ZNF202
gene id: 9615:ZNF202
uniprot id: A0A8I3NM31
uniprot id: A0A8P0NDN3
names: Subcellular Location Annotation
messages: Nucleus

9615:POR
gene id: 9615:POR
uniprot id: A0A8P0SI28
uniprot id: D5LG84
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

9615:ACTL8
gene id: 9615:ACTL8
uniprot id: A0A8C0RVI9
uniprot id: A0A8I3MRJ3
names: Similarity
messages: Belongs to the actin family.

9615:SPP2
gene id: 9615:SPP2
uniprot id: A0A8C0NXJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Secreted

9615:GPR37
gene id: 9615:GPR37
uniprot id: A0A8C0RKU2
uniprot id: A0A8I3MRZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:OR10H1
gene id: 9615:OR10H1
uniprot id: A0A8I3S1I5
uniprot id: A0A8P0TRW3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ALOX12
gene id: 9615:ALOX12
uniprot id: A0A8C0MY34
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:RBL2
gene id: 9615:RBL2
uniprot id: A0A8C0MJZ3
uniprot id: A0A8I3N5E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9615:PER1
gene id: 9615:PER1
uniprot id: A0A8C0P2P0
uniprot id: A0A8I3Q2T4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:NFU1
gene id: 9615:NFU1
uniprot id: A0A8I3PKZ1
uniprot id: A0A8P0SU75
names: Similarity
messages: Belongs to the NifU family.

9615:P2RX7
gene id: 9615:P2RX7
uniprot id: A0A8C0PB41
uniprot id: B0FLR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9615:VIM
gene id: 9615:VIM
uniprot id: A0A8C0N8E3
uniprot id: A0A8I3NU02
names: Similarity
messages: Belongs to the intermediate filament family.

9615:LYRM7
gene id: 9615:LYRM7
uniprot id: A0A8C0PAS5
uniprot id: A0A8I3N3Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9615:ST13
gene id: 9615:ST13
uniprot id: A0A8C0T3A6
uniprot id: A0A8I3NYR1
names: Similarity
messages: Belongs to the FAM10 family.

9615:AXIN2
gene id: 9615:AXIN2
uniprot id: A0A8P0ND93
names: Subcellular Location Annotation
messages: Cytoplasm

9615:SLC44A4
gene id: 9615:SLC44A4
uniprot id: A0A8P0TNH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9615:MICOS10
gene id: 9615:MICOS10
uniprot id: A0A8C0MMN2
uniprot id: A0A8I3MPR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9615:ODF1
gene id: 9615:ODF1
uniprot id: A0A8C0RQ65
uniprot id: A0A8I3N785
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9615:GEM
gene id: 9615:GEM
uniprot id: A0A8C0P6W9
uniprot id: A0A8I3NVP2
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9615:RBM22
gene id: 9615:RBM22
uniprot id: A0A8C0M1Y1
uniprot id: A0A8I3RTA4
names: Similarity
messages: Belongs to the SLT11 family.

9615:MET
gene id: 9615:MET
uniprot id: Q75ZY9
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells.
messages: (Microbial infection) Interacts with L.monocytogenes InlB (Probable). InlB probably dimerizes upon binding to MET, which encourages subsequent dimerization of MET (Probable).
messages: (Microbial infection) Tyrosine phosphorylation is stimulated by L.monocytogenes InlB.
messages: Autophosphorylated in response to ligand binding on Tyr-1235 and Tyr-1236 in the kinase domain leading to further phosphorylation of Tyr-1350 and Tyr-1357 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1350 and Tyr-1366. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity. Interacts with tensin TNS3 (By similarity). Interacts (when phosphorylated) with tensin TNS4 (via SH2 domain); the interaction increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation (By similarity).
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Membrane
messages: O-mannosylation of IPT/TIG domains by TMEM260 is required for protein maturation. O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

9615:TALDO1
gene id: 9615:TALDO1
uniprot id: A0A8C0SF39
uniprot id: H9GW87
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

9615:LDLRAD4
gene id: 9615:LDLRAD4
uniprot id: A0A8C0M7R0
uniprot id: A0A8I3RTI8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:SLC25A2
gene id: 9615:SLC25A2
uniprot id: A0A8C0QF53
uniprot id: A0A8I3RR57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:EOGT
gene id: 9615:EOGT
uniprot id: Q5NDL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
messages: Endoplasmic reticulum lumen

9615:ABCB7
gene id: 9615:ABCB7
uniprot id: A0A8C0RSA9
uniprot id: A0A8I3Q8J3
names: Subcellular Location Annotation
messages: Membrane

9615:MTHFD1
gene id: 9615:MTHFD1
uniprot id: A0A8C0QQP0
uniprot id: A0A8I3MJJ7
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9615:CC2D1A
gene id: 9615:CC2D1A
uniprot id: A0A8P0NI15
names: Similarity
messages: Belongs to the CC2D1 family.

9615:CCNL2
gene id: 9615:CCNL2
uniprot id: A0A8C0LWL9
uniprot id: A0A8I3PXG8
names: Similarity
messages: Belongs to the cyclin family.

9615:GPR137C
gene id: 9615:GPR137C
uniprot id: A0A8I3MN57
uniprot id: A0A8P0SJI8
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9615:OR2D3
gene id: 9615:OR2D3
uniprot id: A0A8C0N7X2
uniprot id: A0A8I3NCK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:GLUL
gene id: 9615:GLUL
uniprot id: A0A8C0PT10
uniprot id: A0A8I3MWJ7
uniprot id: Q8HZM5
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Decamer; composed of two pentamers (PubMed:18005987). Interacts with PALMD (By similarity). Interacts with RHOJ (By similarity).
messages: Glutamine synthetase activity is inhibited by methionine sulfoximine (MSO).
messages: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity).
messages: Membrane
messages: Microsome
messages: Mitochondrion
messages: Palmitoylated; undergoes autopalmitoylation.
messages: Ubiquitinated by ZNRF1.
messages: cytosol

9615:CCNI
gene id: 9615:CCNI
uniprot id: A0A8C0PAT7
uniprot id: A0A8I3S1G0
uniprot id: A0A8P0PI49
names: Similarity
messages: Belongs to the cyclin family.

9615:PRKCQ
gene id: 9615:PRKCQ
uniprot id: A0A8C0LSI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9615:TMEM106A
gene id: 9615:TMEM106A
uniprot id: A0A8C0M8I4
uniprot id: A0A8C0T2K5
uniprot id: A0A8I3MQ60
uniprot id: A0A8I3MXT6
names: Similarity
messages: Belongs to the TMEM106 family.

9615:SMG9
gene id: 9615:SMG9
uniprot id: A0A8C0LYE7
uniprot id: A0A8C0LYF6
uniprot id: A0A8I3MXZ9
uniprot id: A0A8I3N3N0
names: Similarity
messages: Belongs to the SMG9 family.

9615:STX10
gene id: 9615:STX10
uniprot id: A0A8C0TIR9
uniprot id: A0A8I3Q3H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9615:SNRPG
gene id: 9615:SNRPG
uniprot id: A0A8C0QKN0
uniprot id: J9P061
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9615:CCL14
gene id: 9615:CCL14
uniprot id: A0A8I3NM26
uniprot id: A0A8P0SMB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9615:RRP15
gene id: 9615:RRP15
uniprot id: A0A8P0PG79
names: Similarity
messages: Belongs to the RRP15 family.

9615:FAM166B
gene id: 9615:FAM166B
uniprot id: A0A8C0YVW4
uniprot id: A0A8I3N454
names: Similarity
messages: Belongs to the CIMIP2 family.

9615:HOXC5
gene id: 9615:HOXC5
uniprot id: A0A8C0NPX4
uniprot id: A0A8I3PAE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:TNP2
gene id: 9615:TNP2
uniprot id: O77645
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear transition protein 2 family.
messages: Chromosome
messages: Nucleus
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: Testis.
messages: nucleolus

9615:REV1
gene id: 9615:REV1
uniprot id: A0A8C0SRN9
uniprot id: A0A8C0SST4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

9615:FAM76B
gene id: 9615:FAM76B
uniprot id: A0A8C0NYY5
names: Similarity
messages: Belongs to the FAM76 family.

9615:CLCA1
gene id: 9615:CLCA1
uniprot id: A0A8C0NNS9
uniprot id: A0A8I3P659
names: Similarity
messages: Belongs to the CLCR family.

9615:ANKRD34C
gene id: 9615:ANKRD34C
uniprot id: A0A8I3MZ87
uniprot id: A0A8P0PIE9
names: Similarity
messages: Belongs to the ANKRD34 family.

9615:TAF12
gene id: 9615:TAF12
uniprot id: A0A8C0SN31
uniprot id: E2QVZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9615:GSTCD
gene id: 9615:GSTCD
uniprot id: A0A8C0PFQ6
uniprot id: A0A8I3Q3R9
names: Similarity
messages: Belongs to the GSTCD family.

9615:LOC609748
gene id: 9615:LOC609748
uniprot id: A0A8C0TCW0
uniprot id: A0A8I3PNX9
names: Similarity
messages: Belongs to the GroES chaperonin family.

9615:AOX4
gene id: 9615:AOX4
uniprot id: Q2QB48
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9615:CCDC93
gene id: 9615:CCDC93
uniprot id: A0A8C0QF65
uniprot id: A0A8C0QI28
names: Similarity
messages: Belongs to the CCDC93 family.

9615:CREBL2
gene id: 9615:CREBL2
uniprot id: A0A8C0NNU8
uniprot id: A0A8I3PKN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9615:AVPI1
gene id: 9615:AVPI1
uniprot id: A0A8C0P637
uniprot id: A0A8I3PXI4
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9615:SDR16C5
gene id: 9615:SDR16C5
uniprot id: A0A8C0TXX3
uniprot id: A0A8I3S691
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:TUBD1
gene id: 9615:TUBD1
uniprot id: Q8HZV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
messages: Belongs to the tubulin family.
messages: Cytoplasm
messages: Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1.
messages: Nucleus
messages: centriole
messages: cilium

9615:GTPBP8
gene id: 9615:GTPBP8
uniprot id: A0A8C0PKW5
uniprot id: A0A8I3Q118
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

9615:CCT2
gene id: 9615:CCT2
uniprot id: A0A8C0QNN5
uniprot id: A0A8I3NY48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9615:SEPTIN5
gene id: 9615:SEPTIN5
uniprot id: A0A8C0RPW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9615:PIWIL2
gene id: 9615:PIWIL2
uniprot id: A0A8C0TKH6
uniprot id: A0A8I3PR35
names: Similarity
messages: Belongs to the argonaute family.

9615:LOC100687687
gene id: 9615:LOC100687687
uniprot id: A0A8C0S089
uniprot id: A0A8I3MGC7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9615:CYP24A1
gene id: 9615:CYP24A1
uniprot id: A0A8P0NE13
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:PIAS4
gene id: 9615:PIAS4
uniprot id: A0A8C0QIF7
uniprot id: A0A8I3N076
names: Similarity
messages: Belongs to the PIAS family.

9615:IGFBP4
gene id: 9615:IGFBP4
uniprot id: A0A8C0SLN9
uniprot id: A0A8I3NA54
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:UMOD
gene id: 9615:UMOD
uniprot id: A0A8C0PXN1
uniprot id: A0A8I3N8E3
names: Caution
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

9615:ZNF445
gene id: 9615:ZNF445
uniprot id: A0A8C0SKI8
uniprot id: A0A8I3PGF4
names: Subcellular Location Annotation
messages: Nucleus

9615:SMG5
gene id: 9615:SMG5
uniprot id: A0A8C0TB19
uniprot id: A0A8I3NPB5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

9615:CLNS1A
gene id: 9615:CLNS1A
uniprot id: P35521
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Component of the methylosome, a 20S complex containing at least PRMT5/SKB1, WDR77/MEP50 and CLNS1A/pICln. May mediate SNRPD1 and SNRPD3 methylation. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with LSM10 and LSM11 (By similarity).
messages: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (By similarity). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
messages: Nucleus
messages: Was originally thought to be a chloride channel.
messages: cytoskeleton
messages: cytosol

9615:LOC490346
gene id: 9615:LOC490346
uniprot id: A0A8C0PNF9
uniprot id: A0A8I3ME89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9615:TLE2
gene id: 9615:TLE2
uniprot id: A0A8P0NKG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9615:YEATS4
gene id: 9615:YEATS4
uniprot id: A0A8C0MLV8
uniprot id: A0A8I3NXJ8
names: Subcellular Location Annotation
messages: Nucleus

9615:C17H2orf68
gene id: 9615:C17H2orf68
uniprot id: A0A8C0Q442
uniprot id: A0A8I3NUV2
uniprot id: A0A8I3RXW4
uniprot id: A0A8P0PS84
names: Similarity
messages: Belongs to the UPF0561 family.

9615:SMN
gene id: 9615:SMN
uniprot id: O02771
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMN family.
messages: Cajal body
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Homooligomer; may form higher order homooligomers in the dimer to octamer range. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Component of an import snRNP complex composed of KPNB1, RNUT1, SMN1 and ZNF259. Interacts with DDX20, FBL, NOLA1, RNUT1, SYNCRIP and with several spliceosomal snRNP core Sm proteins, including SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE and ILF3. Interacts with GEMIN2; the interaction is direct. Interacts with GEMIN3; the interaction is direct. Interacts with GEMIN8; the interaction is direct. Interacts with SNRPB; the interaction is direct. Interacts (via Tudor domain) with SNRPD1 (via C-terminus); the interaction is direct. Interacts with SNRPD2; the interaction is direct. Interacts (via Tudor domain) with SNRPD3 (via C-terminus); the interaction is direct. Interacts with SNRPE; the interaction is direct. Interacts with OSTF1, LSM10, LSM11 and RPP20/POP7. Interacts (via C-terminal region) with ZPR1 (via C-terminal region). Interacts (via Tudor domain) with COIL. Interacts with SETX; recruits SETX to POLR2A. Interacts with POLR2A (via the C-terminal domain (CTD)). Interacts with PRMT5. Interacts with XRN2. Interacts (via C-terminus) with FMR1 (via C-terminus); the interaction is direct and occurs in a RNA-independent manner. Interacts (via Tudor domain) with SF3B2 ('Arg-508'-methylated form). Interacts with WRAP53/TCAB1. Interacts (via Tudor domain) with ELAVL4 in an RNA-independent manner; the interaction is required for localization of ELAVL4 to RNA granules. Interacts with FRG1.
messages: Perikaryon
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
messages: The Tudor domain mediates association with dimethylarginines, which are common in snRNP proteins.
messages: Z line
messages: axon
messages: gem
messages: neuron projection

9615:CKAP2
gene id: 9615:CKAP2
uniprot id: A0A8C0Q7G0
uniprot id: A0A8I3PJR4
names: Similarity
messages: Belongs to the CKAP2 family.

9615:FAM126A
gene id: 9615:FAM126A
uniprot id: A0A8C0QAC3
uniprot id: A0A8C0QI73
uniprot id: A0A8I3MZQ3
uniprot id: A0A8I3N7M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9615:DMRT1
gene id: 9615:DMRT1
uniprot id: A0A8C0PVM0
uniprot id: A0A8I3MF10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9615:MFSD6
gene id: 9615:MFSD6
uniprot id: A0A8I3S539
uniprot id: A0A8P0SEI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9615:ATOX1
gene id: 9615:ATOX1
uniprot id: Q9TT99
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATX1 family.
messages: Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity).
messages: Homodimer. Interacts with ATP7B. Interacts with ATP7A. Interacts (via dimer form) with SLC31A1 (via C-terminal domain); this interaction improves ATOX1 stability and controls intracellular Cu(I) levels.
messages: The heavy-metal-associated domain (HMA) coordinates a Cu(+) ion via the cysteine residues within the CXXC motif. The transfer of Cu(+) ion from ATOX1 to ATP7A involves the formation of a three-coordinate Cu(+)-bridged heterodimer where the metal is shared between the two metal binding sites of ATOX1 and ATP7A. The Cu(+) ion appears to switch between two coordination modes, forming two links with one protein and one with the other. Cisplatin, a chemotherapeutic drug, can bind the CXXC motif and hinder the release of Cu(+) ion.

9615:SLC25A31
gene id: 9615:SLC25A31
uniprot id: A0A8C0MP15
uniprot id: A0A8I3P406
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9615:ANKRD13A
gene id: 9615:ANKRD13A
uniprot id: A0A8C0P5K6
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9615:OR4C11
gene id: 9615:OR4C11
uniprot id: A0A8C0SHN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:PTK7
gene id: 9615:PTK7
uniprot id: A0A8C0QD72
uniprot id: A0A8I3N574
names: Subcellular Location Annotation
messages: Membrane

9615:MTMR3
gene id: 9615:MTMR3
uniprot id: A0A8C0TGX1
uniprot id: A0A8C0TIQ8
uniprot id: A0A8C0Z432
uniprot id: A0A8I3QC27
uniprot id: A0A8P0TNF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9615:CPXM1
gene id: 9615:CPXM1
uniprot id: A0A8C0T209
uniprot id: A0A8I3NVC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9615:CHMP2A
gene id: 9615:CHMP2A
uniprot id: A0A8C0R9T3
uniprot id: A0A8I3MUN9
names: Similarity
messages: Belongs to the SNF7 family.

9615:RTN1
gene id: 9615:RTN1
uniprot id: Q6IM72
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:FZD2
gene id: 9615:FZD2
uniprot id: A0A8I3N4R2
uniprot id: A0A8P0SIN7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:CD8B
gene id: 9615:CD8B
uniprot id: A0A8C0SQ09
names: Subcellular Location Annotation
messages: Membrane

9615:TAT
gene id: 9615:TAT
uniprot id: A0A8C0T2T1
uniprot id: A0A8I3MYF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

9615:ALDOC
gene id: 9615:ALDOC
uniprot id: A0A8C0Z329
uniprot id: A0A8I3NII5
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9615:WASF2
gene id: 9615:WASF2
uniprot id: A0A8C0RWW1
uniprot id: A0A8I3RVS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9615:GDF5
gene id: 9615:GDF5
uniprot id: A0A8C0P3X1
uniprot id: A0A8I3PHL7
names: Similarity
messages: Belongs to the TGF-beta family.

9615:KCNE3
gene id: 9615:KCNE3
uniprot id: A0A8C0T3Q1
uniprot id: A0A8I3MYQ7
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9615:MAN2B1
gene id: 9615:MAN2B1
uniprot id: A0A8C0TQU3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9615:LHX5
gene id: 9615:LHX5
uniprot id: A0A8C0TNM7
uniprot id: A0A8I3PGV3
names: Subcellular Location Annotation
messages: Nucleus

9615:STX11
gene id: 9615:STX11
uniprot id: A0A8C0MXL0
uniprot id: A0A8I3NPW6
uniprot id: A0A8P0S6C4
names: Similarity
messages: Belongs to the syntaxin family.

9615:VSX2
gene id: 9615:VSX2
uniprot id: A0A8C0S8C2
uniprot id: A0A8I3NIJ9
names: Subcellular Location Annotation
messages: Nucleus

9615:UACA
gene id: 9615:UACA
uniprot id: Q9GL21
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the apoptosome complex, composed of APAF1, pro-caspase-9 and UACA. In the complex, it probably interacts directly with APAF1. Interacts with LGALS3, ARF6 and ACTB. Interacts with RAB39A (By similarity).
messages: Cytoplasm
messages: Highly expressed in adrenal, testis, kidney and large intestine.
messages: Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity).
messages: Nucleus
messages: Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).
messages: Up-regulated in stimulated thyroids. Down-regulated by forskolin and TSH. Up-regulated by EGF.
messages: cytoskeleton

9615:SPX
gene id: 9615:SPX
uniprot id: A0A8C0PBI6
uniprot id: A0A8I3S146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

9615:ABCB9
gene id: 9615:ABCB9
uniprot id: A0A8C0Z6B7
uniprot id: A0A8I3PGC3
uniprot id: A0A8I3PGL4
uniprot id: A0A8P0NA14
names: Subcellular Location Annotation
messages: Membrane

9615:NHS
gene id: 9615:NHS
uniprot id: A0A8C0SS35
uniprot id: A0A8P0PMW4
uniprot id: A0A8P0TSP6
names: Similarity
messages: Belongs to the NHS family.

9615:SLC6A13
gene id: 9615:SLC6A13
uniprot id: A0A8C0RK30
uniprot id: A0A8I3Q066
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9615:RECQL5
gene id: 9615:RECQL5
uniprot id: A0A8C0MBI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9615:ZSCAN26
gene id: 9615:ZSCAN26
uniprot id: A0A8I3P180
uniprot id: A0A8P0NRU8
names: Subcellular Location Annotation
messages: Nucleus

9615:FOXP3
gene id: 9615:FOXP3
uniprot id: D0VYJ3
names: Subcellular Location Annotation
messages: Nucleus

9615:TULP3
gene id: 9615:TULP3
uniprot id: A0A8C0PHH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9615:YOD1
gene id: 9615:YOD1
uniprot id: A0A8C0RQA9
uniprot id: A0A8I3ME45
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

9615:PSMB6
gene id: 9615:PSMB6
uniprot id: A0A8C0MYP5
uniprot id: A0A8I3RT39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9615:UBE4B
gene id: 9615:UBE4B
uniprot id: A0A8C0RF76
uniprot id: A0A8P0TUV4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

9615:PRKAR2A
gene id: 9615:PRKAR2A
uniprot id: A0A8P0TIN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9615:TUBB4B
gene id: 9615:TUBB4B
uniprot id: A0A8C0MG20
uniprot id: A0A8I3PJ87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:SLC35C1
gene id: 9615:SLC35C1
uniprot id: A0A8I3Q1E5
uniprot id: A0A8P0NPU5
names: Subcellular Location Annotation
messages: Membrane

9615:CACNG6
gene id: 9615:CACNG6
uniprot id: A0A8I3RTB9
uniprot id: A0A8P0N5N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

9615:PPP2R2B
gene id: 9615:PPP2R2B
uniprot id: A0A8C0MBY1
uniprot id: A0A8C0MCT4
uniprot id: A0A8C0QDJ1
uniprot id: A0A8C0QDX4
uniprot id: A0A8C0QIB6
uniprot id: A0A8C0QJS9
uniprot id: A0A8C0QKS4
uniprot id: A0A8I3PE40
uniprot id: A0A8I3PIK7
uniprot id: A0A8I3PLH0
uniprot id: A0A8I3PLN4
uniprot id: A0A8I3PN99
uniprot id: A0A8I3S3G0
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9615:SNAP23
gene id: 9615:SNAP23
uniprot id: A0A8C0RQF5
uniprot id: A0A8I3S1Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9615:GHRH
gene id: 9615:GHRH
uniprot id: A0A8C0SWR7
uniprot id: A0A8I3PVA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9615:NFIC
gene id: 9615:NFIC
uniprot id: A0A8C0QH19
uniprot id: A0A8C0QQI3
uniprot id: A0A8I3N3R9
uniprot id: A0A8I3N4G8
uniprot id: A0A8P0T326
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9615:CPA4
gene id: 9615:CPA4
uniprot id: A0A8C0PH37
uniprot id: A0A8I3NVV4
names: Similarity
messages: Belongs to the peptidase M14 family.

9615:SERPINE1
gene id: 9615:SERPINE1
uniprot id: A0A8C0PBU3
uniprot id: A0A8I3MDS4
names: Similarity
messages: Belongs to the serpin family.

9615:GGT7
gene id: 9615:GGT7
uniprot id: A0A8C0QCL0
uniprot id: A0A8I3P300
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9615:LOC100856382
gene id: 9615:LOC100856382
uniprot id: A0A8C0PQI6
uniprot id: A0A8I3PM69
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9615:GSTO1
gene id: 9615:GSTO1
uniprot id: A0A8C0PEQ0
uniprot id: A0A8I3QSL3
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9615:FAM3B
gene id: 9615:FAM3B
uniprot id: A0A8I3S7F3
uniprot id: A0A8P0NR43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9615:PTK2B
gene id: 9615:PTK2B
uniprot id: A0A8C0PBH0
uniprot id: A0A8I3RYS0
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9615:PPP1CB
gene id: 9615:PPP1CB
uniprot id: Q8MJ47
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress (By similarity).
messages: Nucleus
messages: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PPP1R7 and PPP1R12C. Interacts with PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with PPP1R12A and NUAK1; the interaction is direct. Interacts with TRIM28; the interaction is weak. Interacts with FOXP3. Interacts with RRP1B. Interacts with SERPINE1. Interacts with LZTR1 (By similarity).
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity).
messages: nucleolus
messages: nucleoplasm

9615:DGKD
gene id: 9615:DGKD
uniprot id: A0A8C0P9W4
uniprot id: A0A8I3PD88
uniprot id: A0A8P0PEE6
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9615:ADCY9
gene id: 9615:ADCY9
uniprot id: A0A8C0SNG5
uniprot id: A0A8I3ME97
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9615:DDIT4L
gene id: 9615:DDIT4L
uniprot id: A0A8C0TEX6
names: Similarity
messages: Belongs to the DDIT4 family.

9615:COX10
gene id: 9615:COX10
uniprot id: A0A8C0TB64
uniprot id: A0A8I3MWL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

9615:CLDN34
gene id: 9615:CLDN34
uniprot id: A0A8C0RG35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9615:HAL
gene id: 9615:HAL
uniprot id: A0A8C0P4P3
uniprot id: A0A8I3Q1B2
names: Similarity
messages: Belongs to the PAL/histidase family.

9615:CBLB
gene id: 9615:CBLB
uniprot id: A0A8I3PCV8
uniprot id: A0A8P0PEG7
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9615:IL21
gene id: 9615:IL21
uniprot id: Q6L7I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
messages: Secreted

9615:XKR7
gene id: 9615:XKR7
uniprot id: A0A8C0N8Y1
uniprot id: A0A8I3PCE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9615:LOC485255
gene id: 9615:LOC485255
uniprot id: A0A1K0FUE8
uniprot id: A0A8P0TR12
names: Similarity
messages: Belongs to the globin family.

9615:UNC5CL
gene id: 9615:UNC5CL
uniprot id: A0A8I3NPU8
uniprot id: A0A8P0N4Q7
names: Similarity
messages: Belongs to the unc-5 family.

9615:NDUFA3
gene id: 9615:NDUFA3
uniprot id: A0A8C0M2D5
uniprot id: A0A8I3MJP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9615:GDF2
gene id: 9615:GDF2
uniprot id: A0A8C0YWM6
uniprot id: A0A8I3N8R4
names: Similarity
messages: Belongs to the TGF-beta family.

9615:VTI1A
gene id: 9615:VTI1A
uniprot id: A0A8C0NWP4
uniprot id: A0A8C0Z379
uniprot id: A0A8I3Q4G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9615:ME2
gene id: 9615:ME2
uniprot id: A0A8C0SEL5
uniprot id: A0A8I3MHQ2
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9615:LMAN2
gene id: 9615:LMAN2
uniprot id: P49256
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds 2 calcium ions per subunit.
messages: Expressed in kidney, liver, intestine, lung, spleen and heart. Low expression in brain.
messages: Golgi apparatus membrane
messages: Monomer.
messages: Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans.

9615:CTF1
gene id: 9615:CTF1
uniprot id: A0A8C0SEM9
uniprot id: A0A8I3RZV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9615:CCT7
gene id: 9615:CCT7
uniprot id: A0A8C0SV37
uniprot id: A0A8I3S301
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9615:GGH
gene id: 9615:GGH
uniprot id: A0A8I3SCF8
uniprot id: A0A8P0N9N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9615:CRTC1
gene id: 9615:CRTC1
uniprot id: A0A8C0TGH1
uniprot id: A0A8C0TK61
uniprot id: A0A8I3P914
uniprot id: A0A8I3PJT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9615:SATB2
gene id: 9615:SATB2
uniprot id: A0A8C0TGP6
uniprot id: A0A8I3PYG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9615:CPO
gene id: 9615:CPO
uniprot id: A0A8C0TTY5
names: Similarity
messages: Belongs to the peptidase M14 family.

9615:TMBIM6
gene id: 9615:TMBIM6
uniprot id: A0A8C0TLC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9615:DEFB124
gene id: 9615:DEFB124
uniprot id: A0A8C0TGW6
uniprot id: Q30KT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:SCUBE2
gene id: 9615:SCUBE2
uniprot id: A0A8I3NPT0
uniprot id: A0A8P0NTD1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:B3GALT4
gene id: 9615:B3GALT4
uniprot id: Q5TJE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Involved in GM1/GD1B/GA1 ganglioside biosynthesis.

9615:FBL
gene id: 9615:FBL
uniprot id: A0A8I3MM38
uniprot id: A0A8P0SAZ5
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9615:DOP1A
gene id: 9615:DOP1A
uniprot id: A0A8C0MGL7
uniprot id: A0A8I3NGS6
uniprot id: A0A8I3RY73
uniprot id: A0A8P0T296
names: Similarity
messages: Belongs to the dopey family.

9615:OR5H13
gene id: 9615:OR5H13
uniprot id: A0A8C0TDU0
uniprot id: A0A8I3NXK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SENP3
gene id: 9615:SENP3
uniprot id: A0A8I3PS40
uniprot id: A0A8P0NI73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9615:IRF8
gene id: 9615:IRF8
uniprot id: A0A8I3MVZ6
uniprot id: A0A8P0NL13
names: Subcellular Location Annotation
messages: Nucleus

9615:RAB27B
gene id: 9615:RAB27B
uniprot id: A0A8I3MTM0
uniprot id: A0A8P0PHD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9615:SIKE1
gene id: 9615:SIKE1
uniprot id: A0A8C0S5Y6
uniprot id: A0A8I3Q1N8
names: Similarity
messages: Belongs to the SIKE family.

9615:SLC17A1
gene id: 9615:SLC17A1
uniprot id: A0A8C0P4J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

9615:UBA2
gene id: 9615:UBA2
uniprot id: A0A8C0M2R3
uniprot id: A0A8C0QCG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Nucleus
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

9615:CEP57
gene id: 9615:CEP57
uniprot id: A0A8C0YZA9
uniprot id: A0A8I3P1V5
uniprot id: A0A8I3PBW8
uniprot id: A0A8I3S2Y0
uniprot id: A0A8P0N6W6
uniprot id: A0A8P0P4E6
names: Similarity
messages: Belongs to the translokin family.

9615:C26H12orf43
gene id: 9615:C26H12orf43
uniprot id: A0A8C0PLD3
uniprot id: A0A8P0PJ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope

9615:PABPC1
gene id: 9615:PABPC1
uniprot id: A0A8I3Q1H4
uniprot id: A0A8P0NZM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9615:LIN54
gene id: 9615:LIN54
uniprot id: A0A8C0N340
uniprot id: A0A8I3S239
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9615:STAB1
gene id: 9615:STAB1
uniprot id: A0A8I3Q3R5
uniprot id: A0A8P0NBL4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:TSPAN2
gene id: 9615:TSPAN2
uniprot id: A0A8C0S9N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:IL17A
gene id: 9615:IL17A
uniprot id: C6L8D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9615:RPS3A
gene id: 9615:RPS3A
uniprot id: A0A8I3MUG5
uniprot id: A0A8P0NAA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

9615:ATP6V0C
gene id: 9615:ATP6V0C
uniprot id: A0A8C0Z2A2
uniprot id: A0A8I3RRR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9615:TMCC2
gene id: 9615:TMCC2
uniprot id: A0A8P0SF10
names: Similarity
messages: Belongs to the TEX28 family.

9615:LAMP5
gene id: 9615:LAMP5
uniprot id: A0A8P0SB63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Membrane

9615:AP1S2
gene id: 9615:AP1S2
uniprot id: A0A8C0MK23
uniprot id: A0A8C0SIZ2
uniprot id: A0A8C0SKE4
uniprot id: A0A8I3Q5A5
uniprot id: A0A8I3QAU5
uniprot id: A0A8I3QZ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9615:OR7E24
gene id: 9615:OR7E24
uniprot id: G3FJE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ASB8
gene id: 9615:ASB8
uniprot id: A0A8C0PN26
uniprot id: A0A8I3PKA1
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9615:ZSCAN29
gene id: 9615:ZSCAN29
uniprot id: A0A8C0T0X1
uniprot id: A0A8I3PM45
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9615:SRSF1
gene id: 9615:SRSF1
uniprot id: A0A8C0TYS8
uniprot id: A0A8I3P1V7
names: Similarity
messages: Belongs to the splicing factor SR family.

9615:ISCU
gene id: 9615:ISCU
uniprot id: A0A8C0PS73
uniprot id: A0A8I3PX30
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex.

9615:KCNC1
gene id: 9615:KCNC1
uniprot id: Q9XSJ8
names: Subcellular Location Annotation
messages: Membrane

9615:SKAP1
gene id: 9615:SKAP1
uniprot id: A0A8C0LXF5
uniprot id: A0A8I3NS32
names: Similarity
messages: Belongs to the SKAP family.

9615:RANBP17
gene id: 9615:RANBP17
uniprot id: A0A8C0LSX0
uniprot id: A0A8C0RV60
uniprot id: A0A8I3MHU0
uniprot id: A0A8I3MRJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9615:FAM53B
gene id: 9615:FAM53B
uniprot id: A0A8C0TAC6
uniprot id: A0A8I3PQG5
names: Similarity
messages: Belongs to the FAM53 family.

9615:CRSP-4
gene id: 9615:CRSP-4
uniprot id: A0A8C0T4K8
uniprot id: B3XXE9
names: Similarity
messages: Belongs to the calcitonin family.

9615:SLC15A5
gene id: 9615:SLC15A5
uniprot id: A0A8P0SH83
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

9615:CAVIN1
gene id: 9615:CAVIN1
uniprot id: A0A8C0QHE0
uniprot id: A0A8I3NAW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9615:PTOV1
gene id: 9615:PTOV1
uniprot id: A0A8C0YYJ4
uniprot id: A0A8I3S1Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
messages: Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: May interact with CREBBP. Interacts with FLOT1.
messages: Nucleus
messages: perinuclear region

9615:CD34
gene id: 9615:CD34
uniprot id: Q28270
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CD34 family.
messages: Highly glycosylated.
messages: Membrane
messages: On early hematopoietic progenitor cells.
messages: Phosphorylated on serine residues by PKC.
messages: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity).
messages: Selectively expressed on hematopoietic progenitor cells and vascular endothelium.

9615:CAMKMT
gene id: 9615:CAMKMT
uniprot id: A0A8C0NET7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:UCKL1
gene id: 9615:UCKL1
uniprot id: A0A8C0P9J1
uniprot id: A0A8I3PCE6
uniprot id: A0A8I3S1L5
uniprot id: A0A8P0SHX4
uniprot id: A0A8P0TEF2
names: Similarity
messages: Belongs to the uridine kinase family.

9615:TMEM63C
gene id: 9615:TMEM63C
uniprot id: A0A8C0YZU5
uniprot id: A0A8I3MSB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9615:EIF2D
gene id: 9615:EIF2D
uniprot id: A0A8P0NCB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

9615:PVALB
gene id: 9615:PVALB
uniprot id: A0A8C0SA21
uniprot id: A0A8I3N7Z7
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9615:MPP1
gene id: 9615:MPP1
uniprot id: A0A8I3Q2L6
uniprot id: F1PFU5
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

9615:P2RY8
gene id: 9615:P2RY8
uniprot id: A0A8P0TQX2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:PMS2
gene id: 9615:PMS2
uniprot id: A0A8C0P006
uniprot id: A0A8C0SHR0
uniprot id: A0A8I3NEX7
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9615:CYP2E1
gene id: 9615:CYP2E1
uniprot id: Q9MZY0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9615:FERMT1
gene id: 9615:FERMT1
uniprot id: A0A8C0QD59
names: Similarity
messages: Belongs to the kindlin family.

9615:PPIL2
gene id: 9615:PPIL2
uniprot id: A0A8C0TKB6
uniprot id: A0A8I3PX74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

9615:DUSP7
gene id: 9615:DUSP7
uniprot id: A0A8C0TK06
uniprot id: A0A8I3Q5N5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9615:TRPC1
gene id: 9615:TRPC1
uniprot id: A0A8C0MHJ0
uniprot id: A0A8C0MI41
uniprot id: A0A8C0RDN7
uniprot id: A0A8I3PYR3
uniprot id: A0A8I3Q281
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9615:RPL27
gene id: 9615:RPL27
uniprot id: A0A8C0RAK1
uniprot id: A0A8I3MYV4
uniprot id: Q9XSU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Component of the large ribosomal subunit (By similarity). Interacts with RRP1B (By similarity). Component of the large ribosomal subunit. Interacts with RRP1B. Interacts with DHX33 (By similarity).
messages: Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

9615:PFDN5
gene id: 9615:PFDN5
uniprot id: A0A8C0PHS1
uniprot id: A0A8I3PBU2
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9615:MACO1
gene id: 9615:MACO1
uniprot id: Q2TLZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the macoilin family.
messages: Nucleus membrane
messages: Plays a role in the regulation of neuronal activity.
messages: Rough endoplasmic reticulum membrane

9615:GRIN2A
gene id: 9615:GRIN2A
uniprot id: A0A8C0N398
uniprot id: A0A8I3NRD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9615:GNAI2
gene id: 9615:GNAI2
uniprot id: P38400
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. In this context, interacts with GNB2 (By similarity). Interacts with UNC5B (By similarity). Interacts with GPSM1 (By similarity). Interacts with RGS12 and RGS14 (By similarity). Interacts (inactive GDP-bound form) with NUCB1 (via GBA motif); the interaction leads to activation of GNAI3 (By similarity). Interacts (inactive GDP-bound form) with CCDC88C/DAPLE (via GBA motif) (By similarity). Interacts (inactive GDP-bound form) with CCDC8A/GIV (via GBA motif) (By similarity). Interacts with CXCR1 and CXCR2 (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division (By similarity).
messages: Membrane
messages: centrosome

9615:TAX1BP3
gene id: 9615:TAX1BP3
uniprot id: A0A8C0MWY5
uniprot id: A0A8I3NPF4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9615:MYH1
gene id: 9615:MYH1
uniprot id: Q076A6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9615:GPR61
gene id: 9615:GPR61
uniprot id: A0A8C0NEQ8
uniprot id: A0A8I3MME0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:PPM1L
gene id: 9615:PPM1L
uniprot id: A0A8C0NBX2
uniprot id: A0A8I3Q4M2
names: Similarity
messages: Belongs to the PP2C family.

9615:COL1A2
gene id: 9615:COL1A2
uniprot id: O46392
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the fibrillar collagen family.
messages: Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
messages: Trimers of one alpha 2(I) and two alpha 1(I) chains.
messages: Type I collagen is a member of group I collagen (fibrillar forming collagen).
messages: extracellular matrix

9615:TMED9
gene id: 9615:TMED9
uniprot id: A0A8C0M7W2
uniprot id: A0A8I3NA58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:AIFM1
gene id: 9615:AIFM1
uniprot id: A0A8C0MTD8
uniprot id: A0A8C0TCT2
uniprot id: A0A8I3SCX0
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

9615:TSSK2
gene id: 9615:TSSK2
uniprot id: A0A8C0P5X4
uniprot id: A0A8I3Q8N2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:MSMP
gene id: 9615:MSMP
uniprot id: A0A8C0SEN5
uniprot id: A0A8I3ND26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9615:SEMA5A
gene id: 9615:SEMA5A
uniprot id: A0A8C0TN92
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SLC2A11
gene id: 9615:SLC2A11
uniprot id: A0A8I3Q667
uniprot id: A0A8P0NFZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane

9615:CCL25
gene id: 9615:CCL25
uniprot id: Q68A93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).
messages: Secreted

9615:CCDC47
gene id: 9615:CCDC47
uniprot id: A0A8C0RJF2
uniprot id: A0A8I3P7X4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC47 family.
messages: Component of the PAT complex, composed of WDR83OS/Asterix and CCDC47 (PubMed:36261528). The PAT complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47) (PubMed:36261528). The MPT complex associates with the SEC61 complex (PubMed:36261528). Interacts with VCP, HSPA5, DERL1, DERL2 and SELENOS (By similarity).
messages: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261528). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261528). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (PubMed:36261528). Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex (PubMed:36261528). Involved in the regulation of calcium ion homeostasis in the ER (By similarity). Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (By similarity). Has an essential role in the maintenance of ER organization during embryogenesis (By similarity).
messages: Endoplasmic reticulum membrane
messages: Rough endoplasmic reticulum membrane

9615:CPNE6
gene id: 9615:CPNE6
uniprot id: A0A8P0SGL4
names: Similarity
messages: Belongs to the copine family.

9615:OR2F1D
gene id: 9615:OR2F1D
uniprot id: A0A8C0MLA6
uniprot id: A0A8I3NMC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CNTNAP1
gene id: 9615:CNTNAP1
uniprot id: A0A8C0QJD5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: paranodal septate junction

9615:NR0B2
gene id: 9615:NR0B2
uniprot id: A0A8I3NE48
uniprot id: A0A8P0NE91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9615:TLR5
gene id: 9615:TLR5
uniprot id: B2CW36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9615:PEBP1
gene id: 9615:PEBP1
uniprot id: Q3YIX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylethanolamine-binding protein family.
messages: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Involved in the positive regulation of epithelial cell migration. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity).
messages: Cytoplasm
messages: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).
messages: Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade (By similarity).

9615:SLC16A9
gene id: 9615:SLC16A9
uniprot id: A0A8C0Q2J7
uniprot id: A0A8I3MKR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane

9615:PKD2L2
gene id: 9615:PKD2L2
uniprot id: A0A8I3P3A0
uniprot id: A0A8P0S7A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

9615:LOC484867
gene id: 9615:LOC484867
uniprot id: A0A8C0T8J0
uniprot id: A0A8I3RZ52
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:AGL
gene id: 9615:AGL
uniprot id: Q2PQH8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Monomer. Interacts with NHLRC1/malin (By similarity).
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
messages: Ubiquitinated.

9615:ADORA2A
gene id: 9615:ADORA2A
uniprot id: P11617
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (By similarity). May interact with DRD4 (By similarity). Interacts with NECAB2 (By similarity). Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (By similarity).
messages: Receptor for adenosine (PubMed:2125216). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:2125216).
messages: The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.
messages: Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity).

9615:IL18
gene id: 9615:IL18
uniprot id: Q9XSR0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.

9615:LOC100684429
gene id: 9615:LOC100684429
uniprot id: A0A8I3PHH8
uniprot id: A0A8P0SIS5
names: Similarity
messages: Belongs to the BEX family.

9615:NCAPH2
gene id: 9615:NCAPH2
uniprot id: A0A8P0N3U6
names: Similarity
messages: Belongs to the CND2 H2 (condensin-2 subunit 2) family.

9615:CBFA2T3
gene id: 9615:CBFA2T3
uniprot id: A0A8I3MNK6
uniprot id: A0A8P0SW92
names: Similarity
messages: Belongs to the CBFA2T family.

9615:TRAF5
gene id: 9615:TRAF5
uniprot id: A0A8C0T310
uniprot id: C1IPW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9615:IL13
gene id: 9615:IL13
uniprot id: Q9N0W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-4/IL-13 family.
messages: Cytokine that plays important roles in allergic inflammation and immune response to parasite infection. Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils. Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6. Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (By similarity).
messages: Interacts with IL13RA2.
messages: Secreted

9615:BMPR1A
gene id: 9615:BMPR1A
uniprot id: A0A8C0S7K5
uniprot id: A0A8I3MVJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9615:CITED2
gene id: 9615:CITED2
uniprot id: A0A8I3NI02
uniprot id: A0A8P0NN68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9615:ETFDH
gene id: 9615:ETFDH
uniprot id: A0A8C0MFJ0
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9615:LGR6
gene id: 9615:LGR6
uniprot id: A0A8P0SFC4
names: Subcellular Location Annotation
messages: Membrane

9615:ATP2B2
gene id: 9615:ATP2B2
uniprot id: A0A8C0TL23
uniprot id: A0A8I3RVD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:FHL5
gene id: 9615:FHL5
uniprot id: A0A8C0MDM9
uniprot id: A0A8I3N9H8
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9615:PRKRA
gene id: 9615:PRKRA
uniprot id: A0A8C0T5M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRKRA family.
messages: perinuclear region

9615:TOLLIP
gene id: 9615:TOLLIP
uniprot id: A0A8C0PDP9
uniprot id: A0A8I3N9K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9615:GJC1
gene id: 9615:GJC1
uniprot id: A0A140T8E4
uniprot id: A0A8C0M8P9
uniprot id: P28228
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:NOP16
gene id: 9615:NOP16
uniprot id: A0A8C0M441
uniprot id: A0A8I3NM57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9615:MST1R
gene id: 9615:MST1R
uniprot id: A0A8C0RIZ6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:ORAI2
gene id: 9615:ORAI2
uniprot id: A0A8C0QEZ6
uniprot id: A0A8I3MXQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9615:APTX
gene id: 9615:APTX
uniprot id: P61797
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
messages: Interacts with single-strand break repair proteins XRCC1, XRCC4, ADPRT/PARP1 and p53/TP53. Interacts with NCL. Interacts (via FHA-like domain) with MDC1 (phosphorylated).
messages: The C2H2-type zinc finger mediates DNA-binding.
messages: The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4.
messages: The HIT domain is required for enzymatic activity.
messages: The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide.
messages: nucleolus
messages: nucleoplasm

9615:RAPGEF2
gene id: 9615:RAPGEF2
uniprot id: F1PBJ0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAPGEF2 family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a neuronal growth factor (NGF)-dependent manner. Interacts (via C-terminal domain) with NEDD4 (via WW domains); this interaction leads to ubiquitination and degradation via the proteasome pathway in a cAMP-independent manner. Interacts with MAGI1 (via PDZ domain). Interacts with ADRB1 (via C-terminal PDZ motif); the interaction is direct. Interacts (via Ras-associating domain) with RAP1A (via GTP-bound active form). Interacts weakly with HRAS (via GDP- and GTP-bound forms). Interacts (via C-terminal domain) with MAGI2 (via PDZ and WW domains) (By similarity). Interacts with CDH1, CTNNB1 and TJP1.
messages: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions.
messages: Late endosome
messages: Phosphorylation by PLK2 promotes its activity.
messages: The Ras-associating domain is necessary for the Rap guanine nucleotide exchange activity. The N-terminal regionis necessary for cAMP-binding. The PDZ domain is necessary for its targeting to the cell membrane (By similarity).
messages: Ubiquitinated by NEDD4, leading to proteasomal degradation.
messages: perinuclear region

9615:EMR4
gene id: 9615:EMR4
uniprot id: A0A8C0TMI0
uniprot id: Q2Q419
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:MTRF1
gene id: 9615:MTRF1
uniprot id: A0A8C0TE43
uniprot id: A0A8I3NN91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9615:CPB1
gene id: 9615:CPB1
uniprot id: A0A8C0QIC0
uniprot id: A0A8I3PKA8
names: Similarity
messages: Belongs to the peptidase M14 family.

9615:CA4
gene id: 9615:CA4
uniprot id: A0A8C0RSQ2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9615:TMED7
gene id: 9615:TMED7
uniprot id: A0A8C0YWU4
uniprot id: A0A8I3MVE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9615:LIPE
gene id: 9615:LIPE
uniprot id: A0A8C0MC95
uniprot id: A0A8I3RPC4
uniprot id: A0A8P0N7K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Cell membrane
messages: Lipid droplet
messages: caveola
messages: cytosol

9615:ODAM
gene id: 9615:ODAM
uniprot id: A1YQ91
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODAM family.
messages: Cytoplasm
messages: Interacts (via C-terminus) with ARHGEF5.
messages: Nucleus
messages: O-glycosylated.
messages: Secreted
messages: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

9615:BST1
gene id: 9615:BST1
uniprot id: A0A8C0SEW4
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9615:LEAP2
gene id: 9615:LEAP2
uniprot id: A0A8C0N5F5
uniprot id: A0A8I3NJP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9615:ADAM29
gene id: 9615:ADAM29
uniprot id: A0A8C0TC12
uniprot id: A0A8I3P2J4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:ADAM23
gene id: 9615:ADAM23
uniprot id: A0A8P0T6A4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TNFSF11
gene id: 9615:TNFSF11
uniprot id: A0A8C0P5C6
uniprot id: A0A8I3NGJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9615:NCAPD2
gene id: 9615:NCAPD2
uniprot id: A0A8C0Z2G8
uniprot id: A0A8I3Q275
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

9615:APOC3
gene id: 9615:APOC3
uniprot id: A0A8C0Q7Q3
uniprot id: A0A8I3MTA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Secreted

9615:TTC9B
gene id: 9615:TTC9B
uniprot id: A0A8C0M0L8
uniprot id: A0A8I3MTB4
names: Similarity
messages: Belongs to the TTC9 family.

9615:PSMF1
gene id: 9615:PSMF1
uniprot id: A0A8C0MQ36
uniprot id: A0A8C0T7T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

9615:TRPM3
gene id: 9615:TRPM3
uniprot id: A0A8C0Q466
uniprot id: A0A8I3MFL7
names: Subcellular Location Annotation
messages: Membrane

9615:SLC4A10
gene id: 9615:SLC4A10
uniprot id: A0A8C0TF99
uniprot id: A0A8C0Z4E5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

9615:UBE2D1
gene id: 9615:UBE2D1
uniprot id: A0A8C0RUB4
uniprot id: A0A8I3MLM6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:GFRA1
gene id: 9615:GFRA1
uniprot id: A0A8C0TV81
uniprot id: A0A8I3QCB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9615:CENPC
gene id: 9615:CENPC
uniprot id: A0A8P0N5R5
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

9615:EVA1B
gene id: 9615:EVA1B
uniprot id: A0A8C0NX26
names: Similarity
messages: Belongs to the EVA1 family.

9615:TRIB2
gene id: 9615:TRIB2
uniprot id: Q28283
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
messages: Cytoplasm
messages: Highly expressed in the thyroid, also present in ovary and cerebrum.
messages: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity.
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: cytoskeleton

9615:PREB
gene id: 9615:PREB
uniprot id: A0A8C0MJ77
uniprot id: A0A8I3MY57
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9615:SCP2
gene id: 9615:SCP2
uniprot id: A0A8I3S339
uniprot id: A0A8P0SVD2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion

9615:ZNF706
gene id: 9615:ZNF706
uniprot id: A0A8C0NSV7
uniprot id: A0A8I3PZJ0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:CSNK1G1
gene id: 9615:CSNK1G1
uniprot id: A0A8C0NRC3
uniprot id: A0A8C0NSZ5
uniprot id: A0A8C0TNJ8
uniprot id: A0A8I3PHC8
uniprot id: A0A8I3PLM5
uniprot id: A0A8I3PLQ1
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9615:KDR
gene id: 9615:KDR
uniprot id: A0A8C0NTB4
uniprot id: Q2XPT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:NEO1
gene id: 9615:NEO1
uniprot id: A0A8C0NKY7
uniprot id: A0A8C0RKS0
uniprot id: A0A8C0SXG3
uniprot id: A0A8I3S9W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

9615:LOC489591
gene id: 9615:LOC489591
uniprot id: A0A8C0LXD1
uniprot id: A0A8I3NWZ4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9615:ATP6V0D1
gene id: 9615:ATP6V0D1
uniprot id: A0A8C0YZP4
uniprot id: A0A8I3NAA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9615:CRYGB
gene id: 9615:CRYGB
uniprot id: A3RLE1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Monomer.

9615:MCRIP1
gene id: 9615:MCRIP1
uniprot id: A0A8C0PKN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

9615:CBLC
gene id: 9615:CBLC
uniprot id: A0A8C0LXC3
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9615:CRB3
gene id: 9615:CRB3
uniprot id: A0A5F4BST2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Component of a complex composed of CRB3, PALS1 and PATJ (PubMed:12527193). Interacts (via C-terminus) with PALS1 (via PDZ domain) (By similarity). Interacts with PARD6A (By similarity). Interacts (via intracellular domain) with EPB41L5 (By similarity).
messages: Involved in the establishment of cell polarity in mammalian epithelial cells (By similarity). Regulates the morphogenesis of tight junctions (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity).
messages: The PDZ-binding motif is involved in the interactions with PARD6A and PALS1.
messages: tight junction

9615:FAHD2A
gene id: 9615:FAHD2A
uniprot id: A0A8C0QRH7
uniprot id: A0A8I3N070
names: Similarity
messages: Belongs to the FAH family.

9615:LOC478720
gene id: 9615:LOC478720
uniprot id: A0A8C0YZQ5
uniprot id: A0A8I3P6X4
names: Similarity
messages: Belongs to the TMEM14 family.

9615:EBF2
gene id: 9615:EBF2
uniprot id: A0A8C0P653
uniprot id: A0A8I3P166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9615:UTP23
gene id: 9615:UTP23
uniprot id: A0A8C0M6C2
uniprot id: A0A8I3P233
names: Subcellular Location Annotation
messages: nucleolus

9615:RNF146
gene id: 9615:RNF146
uniprot id: A0A8C0RVM2
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9615:EHD2
gene id: 9615:EHD2
uniprot id: A0A8C0PSB6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9615:ATG5
gene id: 9615:ATG5
uniprot id: A0A8C0N3L6
uniprot id: A0A8I3RU83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9615:SDHD
gene id: 9615:SDHD
uniprot id: A0A8C0N794
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9615:TESMIN
gene id: 9615:TESMIN
uniprot id: A0A8P0SPV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9615:SLC37A4
gene id: 9615:SLC37A4
uniprot id: A0A8C0M9B8
uniprot id: A0A8I3MHL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9615:ZKSCAN2
gene id: 9615:ZKSCAN2
uniprot id: A0A8C0RRI8
uniprot id: A0A8I3MF99
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9615:DTNB
gene id: 9615:DTNB
uniprot id: A0A8C0MBC5
uniprot id: A0A8I3PV08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9615:ARAP3
gene id: 9615:ARAP3
uniprot id: A0A8C0Q6C9
uniprot id: A0A8C0QCG5
names: Subcellular Location Annotation
messages: Cytoplasm

9615:CYP2A13
gene id: 9615:CYP2A13
uniprot id: Q307K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:EMC4
gene id: 9615:EMC4
uniprot id: A0A8C0Z1I7
uniprot id: A0A8I3PBW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:CDK2AP2
gene id: 9615:CDK2AP2
uniprot id: A0A8C0PGV6
uniprot id: A0A8I3ND43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9615:NDUFA7
gene id: 9615:NDUFA7
uniprot id: A0A8C0NEJ2
uniprot id: A0A8I3Q774
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

9615:MTAP
gene id: 9615:MTAP
uniprot id: A0A8C0MV73
uniprot id: A0A8I3NWM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9615:ZDHHC4
gene id: 9615:ZDHHC4
uniprot id: A0A8C0YYT7
uniprot id: A0A8I3NP64
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:RBBP4
gene id: 9615:RBBP4
uniprot id: A0A8I3N0Q4
uniprot id: A0A8P0PBF3
names: Subcellular Location Annotation
messages: Nucleus

9615:CDC42BPB
gene id: 9615:CDC42BPB
uniprot id: A0A8P0P7L3
uniprot id: A0A8P0P9Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9615:RAB4A
gene id: 9615:RAB4A
uniprot id: A0A8C0Q6A6
uniprot id: A0A8I3ML15
uniprot id: A0A8P0SGW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9615:ATRAID
gene id: 9615:ATRAID
uniprot id: A0A8C0MJS3
uniprot id: A0A8I3N4W1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CD93
gene id: 9615:CD93
uniprot id: A0A8C0TI12
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:GPN3
gene id: 9615:GPN3
uniprot id: A0A8C0P5Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9615:CMPK1
gene id: 9615:CMPK1
uniprot id: A0A8C0RQJ3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9615:MIOS
gene id: 9615:MIOS
uniprot id: A0A8C0STF0
uniprot id: A0A8I3PD51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane

9615:STK11
gene id: 9615:STK11
uniprot id: A0A8C0NS48
uniprot id: A0A8I3ND82
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.

9615:MSTO1
gene id: 9615:MSTO1
uniprot id: A0A8C0PLQ9
uniprot id: A0A8I3RYJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Mitochondrion outer membrane

9615:IDH3A
gene id: 9615:IDH3A
uniprot id: A0A8C0MAD2
uniprot id: A0A8I3NG17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9615:RNASEH1
gene id: 9615:RNASEH1
uniprot id: A0A8P0NNY0
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9615:UQCRQ
gene id: 9615:UQCRQ
uniprot id: A0A8C0QP45
uniprot id: A0A8I3NJC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9615:CAB39L
gene id: 9615:CAB39L
uniprot id: A0A8C0NVB7
uniprot id: A0A8I3PQG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9615:QRFP
gene id: 9615:QRFP
uniprot id: A0A8C0Q5Y2
uniprot id: A0A8I3PCK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFamide neuropeptide family.
messages: Secreted

9615:PIR
gene id: 9615:PIR
uniprot id: A0A8C0YXE9
uniprot id: A0A8I3QK41
names: Similarity
messages: Belongs to the pirin family.

9615:SST
gene id: 9615:SST
uniprot id: P49670
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure.
messages: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.
messages: May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (By similarity).
messages: Secreted

9615:GJA8
gene id: 9615:GJA8
uniprot id: E2R603
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:RIDA
gene id: 9615:RIDA
uniprot id: A0A8C0SGZ7
uniprot id: A0A8I3PQP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9615:FAM133A
gene id: 9615:FAM133A
uniprot id: A0A8C0NEI2
uniprot id: A0A8I3PTA0
names: Similarity
messages: Belongs to the FAM133 family.

9615:RPA3
gene id: 9615:RPA3
uniprot id: A0A8C0SS84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9615:TPK1
gene id: 9615:TPK1
uniprot id: A0A8C0YTB3
uniprot id: A0A8I3NER7
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9615:TMLHE
gene id: 9615:TMLHE
uniprot id: A0A8C0TFY1
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

9615:HSD17B4
gene id: 9615:HSD17B4
uniprot id: A0A8C0Q1M8
uniprot id: A0A8C0RXL9
uniprot id: A0A8I3N3X9
names: Subcellular Location Annotation
messages: Peroxisome

9615:UOX
gene id: 9615:UOX
uniprot id: Q5FZI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

9615:CORO1C
gene id: 9615:CORO1C
uniprot id: A0A8I3PZZ4
uniprot id: A0A8P0PGW2
names: Similarity
messages: Belongs to the WD repeat coronin family.

9615:IRX6
gene id: 9615:IRX6
uniprot id: A0A8C0RDW5
names: Subcellular Location Annotation
messages: Nucleus

9615:INTS10
gene id: 9615:INTS10
uniprot id: A0A8C0P7A1
uniprot id: A0A8C0PH73
uniprot id: A0A8C0STH1
uniprot id: A0A8I3P7T7
uniprot id: A0A8I3S224
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9615:DLGAP2
gene id: 9615:DLGAP2
uniprot id: A0A8I3P7E0
uniprot id: A0A8P0T6L0
names: Similarity
messages: Belongs to the SAPAP family.

9615:UBA6
gene id: 9615:UBA6
uniprot id: A0A8P0P6L4
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9615:PDS5B
gene id: 9615:PDS5B
uniprot id: A0A8C0PK11
uniprot id: A0A8C0RT40
uniprot id: A0A8I3NK22
uniprot id: A0A8I3NVE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDS5 family.
messages: Nucleus

9615:DYNLT1
gene id: 9615:DYNLT1
uniprot id: A0A8C0NCN5
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9615:LOC479600
gene id: 9615:LOC479600
uniprot id: A0A8C0MFE0
uniprot id: A0A8C0MIZ7
uniprot id: A0A8C0MM34
uniprot id: A0A8C0MP39
uniprot id: A0A8C0SRZ3
uniprot id: A0A8I3PZ80
uniprot id: A0A8I3Q5E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTNNBIP1 family.
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

9615:ATP10D
gene id: 9615:ATP10D
uniprot id: A0A8C0TNZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:TYROBP
gene id: 9615:TYROBP
uniprot id: A0A8C0MRH7
uniprot id: A0A8I3MB67
uniprot id: D3GGD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

9615:MTFR1
gene id: 9615:MTFR1
uniprot id: A0A8P0NSS4
uniprot id: A0A8P0P4W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9615:SPAST
gene id: 9615:SPAST
uniprot id: A0A8C0SH39
uniprot id: A0A8I3NPL4
uniprot id: A0A8P0SB67
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.
messages: Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.
messages: Membrane
messages: Midbody
messages: Nucleus
messages: axon
messages: centrosome
messages: cytoskeleton
messages: perinuclear region
messages: spindle

9615:FZR1
gene id: 9615:FZR1
uniprot id: A0A8C0QM73
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9615:OXT
gene id: 9615:OXT
uniprot id: A0A8C0SUC8
uniprot id: A0A8I3NWL0
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9615:CADM3
gene id: 9615:CADM3
uniprot id: A0A8C0NGL7
uniprot id: A0A8I3NXI6
names: Similarity
messages: Belongs to the nectin family.

9615:REV3L
gene id: 9615:REV3L
uniprot id: A0A8C0MFV9
uniprot id: A0A8C0S252
uniprot id: A0A8I3P310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9615:MMP27
gene id: 9615:MMP27
uniprot id: A0A8P0NGJ3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9615:PPY
gene id: 9615:PPY
uniprot id: P01299
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2.
messages: Secreted

9615:LDB1
gene id: 9615:LDB1
uniprot id: A0A8C0PVD8
uniprot id: A0A8I3PGY7
names: Similarity
messages: Belongs to the LDB family.

9615:HHEX
gene id: 9615:HHEX
uniprot id: A0A8C0Z3B6
uniprot id: A0A8I3NTG1
names: Subcellular Location Annotation
messages: Nucleus

9615:PLXNB1
gene id: 9615:PLXNB1
uniprot id: A0A8P0NEM9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:SLC35E1
gene id: 9615:SLC35E1
uniprot id: A0A8I3Q9H2
uniprot id: A0A8P0NHB2
names: Subcellular Location Annotation
messages: Membrane

9615:MANBAL
gene id: 9615:MANBAL
uniprot id: A0A8C0RTS5
uniprot id: A0A8I3SBD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9615:LIN7C
gene id: 9615:LIN7C
uniprot id: A0A8C0P445
uniprot id: A0A8I3NTY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9615:TM9SF2
gene id: 9615:TM9SF2
uniprot id: A0A8C0MI90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9615:MAP1LC3C
gene id: 9615:MAP1LC3C
uniprot id: A0A8P0NSP7
names: Similarity
messages: Belongs to the ATG8 family.

9615:RBM46
gene id: 9615:RBM46
uniprot id: A0A8C0MPP3
uniprot id: A0A8I3NQ34
names: Subcellular Location Annotation
messages: Cytoplasm

9615:ABCC1
gene id: 9615:ABCC1
uniprot id: Q6UR05
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: MK 571 inhibits sphingosine 1-phosphate and leukotriene C4 export.
messages: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (By similarity) (PubMed:12516967). Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (By similarity). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (By similarity).

9615:MPP6
gene id: 9615:MPP6
uniprot id: A0A8C0M7B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane

9615:RFFL
gene id: 9615:RFFL
uniprot id: A0A8C0RMV6
uniprot id: A0A8I3NRZ5
names: Subcellular Location Annotation
messages: Cell membrane

9615:YKT6
gene id: 9615:YKT6
uniprot id: A0A8I3NNA0
uniprot id: A0A8P0N5V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

9615:TAAR4
gene id: 9615:TAAR4
uniprot id: A0A8C0SJK2
uniprot id: D8KZJ4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:ADGRE1
gene id: 9615:ADGRE1
uniprot id: Q2Q422
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:OGG1
gene id: 9615:OGG1
uniprot id: A0A8I3RV29
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

9615:C1GALT1
gene id: 9615:C1GALT1
uniprot id: A0A8P0N5A6
names: Subcellular Location Annotation
messages: Membrane

9615:MID1IP1
gene id: 9615:MID1IP1
uniprot id: A0A8C0N439
uniprot id: A0A8I3PRW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9615:KPNA1
gene id: 9615:KPNA1
uniprot id: A0A8C0TH72
uniprot id: A0A8I3PVT7
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9615:PPM1E
gene id: 9615:PPM1E
uniprot id: A0A8C0MHX9
uniprot id: A0A8I3S6N6
names: Similarity
messages: Belongs to the PP2C family.

9615:SEC61G
gene id: 9615:SEC61G
uniprot id: P60058
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:8107851). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:8107851). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:36261528). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity).
messages: Endoplasmic reticulum membrane
messages: The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:8107851, PubMed:36261528). The SEC61 channel associates with the multi-pass translocon (MPT) complex (PubMed:36261528).

9615:TFF2
gene id: 9615:TFF2
uniprot id: Q863J2
names: Function
names: Subcellular Location Annotation
messages: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).
messages: Secreted

9615:KRT41
gene id: 9615:KRT41
uniprot id: A0A8C0YW62
uniprot id: A0A8I3RZQ2
names: Similarity
messages: Belongs to the intermediate filament family.

9615:CCL20
gene id: 9615:CCL20
uniprot id: A0A8C0PBJ7
uniprot id: Q68AP1
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9615:IDH3G
gene id: 9615:IDH3G
uniprot id: A0A8I3Q6D6
uniprot id: A0A8P0NLJ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9615:CCN2
gene id: 9615:CCN2
uniprot id: A0A8C0RBZ9
uniprot id: A0A8I3MT25
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:LOC403555
gene id: 9615:LOC403555
uniprot id: A0A8C0SS75
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9615:CRYBA1
gene id: 9615:CRYBA1
uniprot id: A0A8C0N1A3
uniprot id: A2IBY9
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9615:C6
gene id: 9615:C6
uniprot id: A0A8P0T891
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:NDUFC1
gene id: 9615:NDUFC1
uniprot id: A0A8I3S311
uniprot id: A0A8P0TCX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:LOC490151
gene id: 9615:LOC490151
uniprot id: A0A8C0QDD4
uniprot id: A0A8I3NW45
names: Subcellular Location Annotation
messages: Membrane

9615:SEPTIN12
gene id: 9615:SEPTIN12
uniprot id: A0A8C0MFA1
uniprot id: A0A8I3P0Z9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9615:PHYKPL
gene id: 9615:PHYKPL
uniprot id: A0A8I3NDG4
uniprot id: A0A8P0N3J5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9615:CACNB1
gene id: 9615:CACNB1
uniprot id: A0A8C0PW50
uniprot id: A0A8I3NL57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Membrane
messages: sarcolemma

9615:SPIC
gene id: 9615:SPIC
uniprot id: A0A8P0N9P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:HSPB7
gene id: 9615:HSPB7
uniprot id: A0A8I3MPE1
uniprot id: A0A8P0TM50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Nucleus

9615:AMZ2
gene id: 9615:AMZ2
uniprot id: A0A8C0LST9
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9615:APOH
gene id: 9615:APOH
uniprot id: P33703
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Expressed by the liver and secreted in plasma.
messages: Secreted

9615:PPP3CA
gene id: 9615:PPP3CA
uniprot id: A0A8C0P395
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9615:PPIL3
gene id: 9615:PPIL3
uniprot id: A0A8C0TCG0
uniprot id: A0A8I3Q7S3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9615:CLN8
gene id: 9615:CLN8
uniprot id: Q5JZQ7
names: Disease Annotation
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.
messages: Defects in CLN8 are a cause of a form of neuronal ceroid lipofuscinosis (NCL) in English setters.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with CLN5. Interacts with CLN3 (By similarity).

9615:ACOT8
gene id: 9615:ACOT8
uniprot id: A0A8C0QB21
uniprot id: A0A8I3NZF5
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9615:MSR1
gene id: 9615:MSR1
uniprot id: A0A8C0Q7U5
uniprot id: A0A8I3NVT5
names: Subcellular Location Annotation
messages: Membrane

9615:MMP20
gene id: 9615:MMP20
uniprot id: A0A8C0TF13
uniprot id: A0A8I3RPK2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9615:LOC606786
gene id: 9615:LOC606786
uniprot id: A0A8C0SWW3
uniprot id: A0A8I3N786
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9615:ALLC
gene id: 9615:ALLC
uniprot id: A0A8C0RLR4
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

9615:REC8
gene id: 9615:REC8
uniprot id: A0A8P0PPD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9615:PPRC1
gene id: 9615:PPRC1
uniprot id: A0A8C0TJN8
uniprot id: A0A8I3PU28
uniprot id: A0A8P0NC30
names: Subcellular Location Annotation
messages: Nucleus

9615:PDSS2
gene id: 9615:PDSS2
uniprot id: A0A8P0TD00
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9615:CCDC126
gene id: 9615:CCDC126
uniprot id: A0A8C0QBU6
uniprot id: A0A8I3N8E5
names: Subcellular Location Annotation
messages: Secreted

9615:ATXN1L
gene id: 9615:ATXN1L
uniprot id: A0A8C0MUK5
uniprot id: A0A8I3RUM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9615:MFSD11
gene id: 9615:MFSD11
uniprot id: A0A8C0RYI3
uniprot id: A0A8I3NZW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9615:FSHB
gene id: 9615:FSHB
uniprot id: A0A8C0QEM9
uniprot id: E2RJZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9615:CMC2
gene id: 9615:CMC2
uniprot id: A0A8C0RAA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9615:TFEC
gene id: 9615:TFEC
uniprot id: A0A8C0YZM2
uniprot id: A0A8I3MZG5
uniprot id: A0A8I3N2H0
uniprot id: A0A8P0PBP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9615:SLC26A10
gene id: 9615:SLC26A10
uniprot id: A0A8C0SS99
uniprot id: A0A8I3NPA1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:ZNF252
gene id: 9615:ZNF252
uniprot id: Q9XSR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9615:NR1H4
gene id: 9615:NR1H4
uniprot id: A0A8C0S616
uniprot id: A0A8C0S6D2
uniprot id: A0A8I3N2S7
uniprot id: A0A8P0N9A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9615:PDHB
gene id: 9615:PDHB
uniprot id: A0A8C0QIK1
uniprot id: A0A8I3S3U9
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9615:NAGK
gene id: 9615:NAGK
uniprot id: A0A8I3P9K5
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9615:MCOLN1
gene id: 9615:MCOLN1
uniprot id: A0A8C0PCC1
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9615:PORCN
gene id: 9615:PORCN
uniprot id: A0A8C0T3R8
uniprot id: A0A8C0T5T0
uniprot id: A0A8C0Z275
uniprot id: A0A8I3Q7P5
uniprot id: A0A8I3QBN8
uniprot id: A0A8I3QCY6
names: Subcellular Location Annotation
messages: Membrane

9615:ARVCF
gene id: 9615:ARVCF
uniprot id: A0A8I3Q0E4
uniprot id: A0A8P0SZL0
names: Similarity
messages: Belongs to the beta-catenin family.

9615:MMP3
gene id: 9615:MMP3
uniprot id: Q6Y4Q5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 4 Ca(2+) ions per subunit.
messages: Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Acts also intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. In addition, plays a role in immune response and possesses antiviral activity against various viruses. Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

9615:ACE2
gene id: 9615:ACE2
uniprot id: C7ECV0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9615:CYP2B6
gene id: 9615:CYP2B6
uniprot id: P24460
uniprot id: X5L555
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: By phenobarbital.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:CTSC
gene id: 9615:CTSC
uniprot id: O97578
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Binds 1 Cl(-) ion per heavy chain.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.
messages: The N-terminus of the heavy chain is heterogeneously processed to produce four different chains.
messages: Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B.

9615:SCUBE3
gene id: 9615:SCUBE3
uniprot id: A0A8C0SNU3
uniprot id: A0A8C0SSN2
uniprot id: A0A8C0YYW6
uniprot id: A0A8I3SBJ8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:TRPV4
gene id: 9615:TRPV4
uniprot id: B2KN54
names: Subcellular Location Annotation
messages: Membrane

9615:MRPL4
gene id: 9615:MRPL4
uniprot id: A0A8C0TFP8
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

9615:FAM83B
gene id: 9615:FAM83B
uniprot id: A0A8C0NCG0
uniprot id: A0A8I3NIF4
names: Similarity
messages: Belongs to the FAM83 family.

9615:PDCD10
gene id: 9615:PDCD10
uniprot id: A0A8C0S1G8
uniprot id: A0A8I3PGJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9615:MFN2
gene id: 9615:MFN2
uniprot id: A0A8C0Q6Z6
uniprot id: E2R3M9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9615:CHRNB1
gene id: 9615:CHRNB1
uniprot id: A0A8C0QFR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:RC3H2
gene id: 9615:RC3H2
uniprot id: A0A8C0Q0W9
uniprot id: A0A8I3NF19
names: Subcellular Location Annotation
messages: P-body

9615:KIAA2013
gene id: 9615:KIAA2013
uniprot id: A0A8C0NXH3
uniprot id: A0A8I3RRT8
names: Subcellular Location Annotation
messages: Membrane

9615:LOC607080
gene id: 9615:LOC607080
uniprot id: A0A8C0M5Q4
uniprot id: A0A8I3QSA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

9615:BEX5
gene id: 9615:BEX5
uniprot id: A0A8C0NLB0
uniprot id: A0A8I3PGX6
names: Similarity
messages: Belongs to the BEX family.

9615:PMCH
gene id: 9615:PMCH
uniprot id: Q5XXR2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the melanin-concentrating hormone family.
messages: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal.
messages: Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6 (By similarity).
messages: Secreted

9615:UBA5
gene id: 9615:UBA5
uniprot id: A0A8C0Z441
uniprot id: A0A8I3Q0C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9615:BOLA3
gene id: 9615:BOLA3
uniprot id: A0A8C0PBZ2
uniprot id: A0A8I3PPD6
names: Similarity
messages: Belongs to the BolA/IbaG family.

9615:RBPJ
gene id: 9615:RBPJ
uniprot id: A0A8C0PNU0
uniprot id: A0A8I3N3F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9615:MRPS25
gene id: 9615:MRPS25
uniprot id: A0A8C0T4Q9
uniprot id: A0A8I3PWG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9615:AAR2
gene id: 9615:AAR2
uniprot id: A0A8C0RT16
uniprot id: A0A8I3PVG7
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

9615:ARCN1
gene id: 9615:ARCN1
uniprot id: A0A8C0Q393
uniprot id: A0A8I3MEN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9615:RAF1
gene id: 9615:RAF1
uniprot id: A0A8C0P9J5
uniprot id: A0A8C0TEU4
uniprot id: A0A8I3PZA0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9615:PRAME
gene id: 9615:PRAME
uniprot id: A0A8C0SVC7
uniprot id: A0A8I3Q9E0
names: Similarity
messages: Belongs to the PRAME family.

9615:TMEM88B
gene id: 9615:TMEM88B
uniprot id: A0A8I3PKE0
uniprot id: A0A8P0PH68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9615:SUPT6H
gene id: 9615:SUPT6H
uniprot id: A0A8C0N502
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9615:TET3
gene id: 9615:TET3
uniprot id: A0A8I3PD47
uniprot id: A0A8P0SDT9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9615:LOC477647
gene id: 9615:LOC477647
uniprot id: A0A8I3NXS4
uniprot id: A0A8P0NCP9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:SLC46A2
gene id: 9615:SLC46A2
uniprot id: Q866G7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. SLC46A family.
messages: Cell membrane
messages: Endosome membrane
messages: Glycosylated.
messages: Highly expressed by the epididymal duct epithelium.
messages: Proton-coupled transporter that delivers pathogen-associated or danger-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes or tissue injury (By similarity). Has selectivity toward muropeptides that contain the amino acid diaminopimelic acid (DAP-type peptidoglycan muropeptides) including Tri-DAP and tracheal toxin (TCT), common in Gram-negative bacteria and Gram-positive bacilli. In the context of immune recognition of skin microbiota, shuttles bacterial muropeptides across the endolysosomal membranes into the cytosol for recognition by NOD1, triggering MYD88-dependent secretion of IL1A and neutrophil recruitment in a pyroptosis-type inflammatory process (By similarity). To a lesser extent and redundantly, transports muramyl dipeptides derived from most bacterial proteoglycans, eliciting NOD2 receptor activation and downstream inflammatory responses (By similarity). Postulated to function as an importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. Selectively imports cGAMPs derived from pathogenic bacteria such as 3'3'-cGAMP thus providing for differential immune recognition of pathogenic versus commensal bacteria. During tumorigenesis may transport extracellular tumor-derived 2'3'-cGAMP across the plasma membrane of M1-polarized macrophages to activate the anti-tumoral stimulator of interferon genes (STING) pathway (By similarity). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable).

9615:RNF13
gene id: 9615:RNF13
uniprot id: A0A8C0S8I5
uniprot id: A0A8I3S8K2
names: Subcellular Location Annotation
messages: Membrane

9615:KIAA1191
gene id: 9615:KIAA1191
uniprot id: A0A8C0M4I0
uniprot id: A0A8C0T0S5
uniprot id: A0A8I3NN97
uniprot id: A0A8I3NNF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9615:RAB3IP
gene id: 9615:RAB3IP
uniprot id: A0A8C0QF51
uniprot id: A0A8C0QR02
uniprot id: A0A8I3S0B6
names: Similarity
messages: Belongs to the SEC2 family.

9615:RAB19
gene id: 9615:RAB19
uniprot id: A0A8C0MCH3
uniprot id: A0A8I3Q624
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane

9615:LIPH
gene id: 9615:LIPH
uniprot id: A0A8C0TTM1
uniprot id: A0A8I3QWY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9615:ACSM5
gene id: 9615:ACSM5
uniprot id: A0A8C0LUZ2
uniprot id: A0A8I3RUC4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:IL16
gene id: 9615:IL16
uniprot id: A0A8P0NFS4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
messages: Nucleus
messages: Secreted

9615:MAN2A2
gene id: 9615:MAN2A2
uniprot id: A0A8P0PIB2
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9615:LAMA3
gene id: 9615:LAMA3
uniprot id: A0A8P0TG28
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9615:GRIK4
gene id: 9615:GRIK4
uniprot id: A0A8I3NF03
uniprot id: A0A8P0NDW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9615:TECPR1
gene id: 9615:TECPR1
uniprot id: A0A8C0SE49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TECPR1 family.
messages: Lysosome membrane
messages: autophagosome membrane

9615:ARID5B
gene id: 9615:ARID5B
uniprot id: A0A8I3MRZ3
uniprot id: A0A8P0SS74
names: Similarity
messages: Belongs to the ARID5B family.

9615:LHFPL4
gene id: 9615:LHFPL4
uniprot id: A0A8C0RFK3
uniprot id: A0A8I3RVE6
names: Subcellular Location Annotation
messages: Membrane

9615:COQ7
gene id: 9615:COQ7
uniprot id: A0A8P0SM97
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9615:MEF2C
gene id: 9615:MEF2C
uniprot id: A0A8C0MTG5
uniprot id: A0A8C0RW75
uniprot id: A0A8I3NTX7
uniprot id: A0A8I3P305
uniprot id: A0A8I3P461
uniprot id: A0A8I3S009
uniprot id: A0A8P0PN16
uniprot id: A0A8P0PNL8
names: Subcellular Location Annotation
messages: Nucleus

9615:COPB2
gene id: 9615:COPB2
uniprot id: A0A8C0QHX9
uniprot id: A0A8I3S666
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

9615:ELL3
gene id: 9615:ELL3
uniprot id: A0A8C0NM92
uniprot id: A0A8I3Q8S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9615:HCRTR2
gene id: 9615:HCRTR2
uniprot id: Q9TUP7
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Defects in HCRTR2 are a cause of an autosomal recessive form of narcolepsy, observed in labradors, dobermans and dachshunds. Narcolepsy is a neurological sleep disorder affecting animals and humans, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. As in humans, most cases of canine narcolepsy are sporadic but an autosomal recessive form was also observed.
messages: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
messages: The N-terminal region is required for orexin signaling.

9615:EARS2
gene id: 9615:EARS2
uniprot id: A0A8I3MJU3
uniprot id: A0A8P0NJ28
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9615:CLDN19
gene id: 9615:CLDN19
uniprot id: A0A8C0S3A9
uniprot id: A0A8I3S1X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:TMED2
gene id: 9615:TMED2
uniprot id: A0A8C0PZ68
uniprot id: A0A8I3P2C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9615:EGF
gene id: 9615:EGF
uniprot id: Q9BEA0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
messages: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (By similarity). Interacts with RHBDF2 (By similarity).
messages: Membrane

9615:ITPR1
gene id: 9615:ITPR1
uniprot id: A0A8P0PSX4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9615:SNAPIN
gene id: 9615:SNAPIN
uniprot id: A0A8C0Q5P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9615:ZKSCAN4
gene id: 9615:ZKSCAN4
uniprot id: A0A8C0P1M4
names: Subcellular Location Annotation
messages: Nucleus

9615:ESRRG
gene id: 9615:ESRRG
uniprot id: A0A8C0PB38
uniprot id: A0A8I3PTN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9615:PPFIA1
gene id: 9615:PPFIA1
uniprot id: A0A8C0PD62
uniprot id: A0A8I3NTY6
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9615:SLC44A5
gene id: 9615:SLC44A5
uniprot id: A0A8C0NPM6
uniprot id: A0A8I3MUR9
uniprot id: A0A8P0SPA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9615:LPIN2
gene id: 9615:LPIN2
uniprot id: A0A8I3RQV6
uniprot id: A0A8P0NTR6
names: Similarity
messages: Belongs to the lipin family.

9615:FICD
gene id: 9615:FICD
uniprot id: A0A8I3Q076
names: Similarity
messages: Belongs to the fic family.

9615:SLC46A3
gene id: 9615:SLC46A3
uniprot id: A0A8C0Z0Y0
uniprot id: A0A8I3S3B6
names: Subcellular Location Annotation
messages: Membrane

9615:NEU1
gene id: 9615:NEU1
uniprot id: A0A8C0SEP1
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9615:MRPL32
gene id: 9615:MRPL32
uniprot id: A0A8C0MFI8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9615:DDB2
gene id: 9615:DDB2
uniprot id: A0A8C0S6B1
uniprot id: A0A8I3PWX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

9615:FABP3
gene id: 9615:FABP3
uniprot id: A0A8C0RV08
uniprot id: A0A8I3N3X1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9615:CA1
gene id: 9615:CA1
uniprot id: A0A8C0Z3W7
uniprot id: A0A8I3S2I1
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9615:THPO
gene id: 9615:THPO
uniprot id: A0A8C0Z6K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

9615:TBC1D7
gene id: 9615:TBC1D7
uniprot id: A0A8C0SZI2
uniprot id: A0A8C0Z0V8
uniprot id: A0A8I3PA10
uniprot id: A0A8I3PGX1
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9615:OR5I1
gene id: 9615:OR5I1
uniprot id: Q95154
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Putative odorant or sperm cell receptor.

9615:EFS
gene id: 9615:EFS
uniprot id: A0A8P0SGH4
names: Similarity
messages: Belongs to the CAS family.

9615:SLBP2
gene id: 9615:SLBP2
uniprot id: A0A8C0MIE8
uniprot id: A0A8I3PJN0
names: Similarity
messages: Belongs to the SLBP family.

9615:CNOT11
gene id: 9615:CNOT11
uniprot id: A0A8C0SJP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

9615:NXPH1
gene id: 9615:NXPH1
uniprot id: A0A8I3PJL7
uniprot id: A0A8P0PHJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9615:HMGCL
gene id: 9615:HMGCL
uniprot id: A0A8C0LXZ1
uniprot id: A0A8I3P3W0
uniprot id: A0A8P0SHQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

9615:TMOD2
gene id: 9615:TMOD2
uniprot id: A0A8C0PIM9
uniprot id: A0A8I3PZS1
names: Subcellular Location Annotation
messages: cytoskeleton

9615:AADACL2
gene id: 9615:AADACL2
uniprot id: A0A8P0NAV8
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9615:CD2
gene id: 9615:CD2
uniprot id: A0A8C0SEN8
uniprot id: A0A8I3Q5Y3
names: Subcellular Location Annotation
messages: Membrane

9615:SLC25A25
gene id: 9615:SLC25A25
uniprot id: A0A8C0N732
uniprot id: A0A8C0RIS5
uniprot id: A0A8C0STK7
uniprot id: A0A8C0SUJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:OSGEP
gene id: 9615:OSGEP
uniprot id: A0A8I3PG21
uniprot id: A0A8P0NR55
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleus

9615:RPS27
gene id: 9615:RPS27
uniprot id: A0A8C0P2Q4
uniprot id: A0A8I3NWH5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9615:PTBP1
gene id: 9615:PTBP1
uniprot id: A0A8C0S8Q6
uniprot id: A0A8I3NY06
names: Subcellular Location Annotation
messages: Nucleus

9615:CUL4B
gene id: 9615:CUL4B
uniprot id: A0A8C0P7H0
names: Similarity
messages: Belongs to the cullin family.

9615:PSMD8
gene id: 9615:PSMD8
uniprot id: A0A8C0NGQ9
uniprot id: A0A8I3N165
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

9615:TMC5
gene id: 9615:TMC5
uniprot id: A0A8C0NXE6
uniprot id: A0A8C0Q0G1
uniprot id: A0A8I3N854
uniprot id: A0A8I3NCG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9615:PAPSS1
gene id: 9615:PAPSS1
uniprot id: A0A8P0NDD9
uniprot id: A0A8P0NXQ1
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9615:TREX1
gene id: 9615:TREX1
uniprot id: A0A8C0PDI4
uniprot id: A0A8C0PDL7
uniprot id: A0A8I3MZA0
uniprot id: A0A8I3N0M9
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9615:VPS72
gene id: 9615:VPS72
uniprot id: A0A8C0SFA2
uniprot id: A0A8I3PDL5
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9615:SLC16A11
gene id: 9615:SLC16A11
uniprot id: A0A8C0Q9F7
names: Subcellular Location Annotation
messages: Membrane

9615:KDM3A
gene id: 9615:KDM3A
uniprot id: A0A8C0SSR7
uniprot id: A0A8I3NDS9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9615:DVL3
gene id: 9615:DVL3
uniprot id: A0A8C0TMQ9
uniprot id: A0A8I3PTY8
names: Similarity
messages: Belongs to the DSH family.

9615:MAP3K12
gene id: 9615:MAP3K12
uniprot id: A0A8C0PNU4
uniprot id: A0A8I3NYB5
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: May be an activator of the JNK/SAPK pathway.

9615:MGAT2
gene id: 9615:MGAT2
uniprot id: A0A8C0RW58
uniprot id: A0A8I3MIH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

9615:PLSCR1
gene id: 9615:PLSCR1
uniprot id: A0A8C0MKS2
uniprot id: A0A8I3PEX0
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9615:KLC1
gene id: 9615:KLC1
uniprot id: A0A8C0SGV3
uniprot id: A0A8C0SHY2
uniprot id: A0A8C0YX05
uniprot id: A0A8I3NY52
uniprot id: A0A8I3P4G7
uniprot id: A0A8I3P532
uniprot id: A0A8P0SMM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9615:DAPK3
gene id: 9615:DAPK3
uniprot id: A0A8C0MCW0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:GNG14
gene id: 9615:GNG14
uniprot id: A0A8C0TS65
uniprot id: A0A8I3NQF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:PIH1D1
gene id: 9615:PIH1D1
uniprot id: A0A8C0LTY3
uniprot id: A0A8C0T108
uniprot id: A0A8I3PNR6
names: Similarity
messages: Belongs to the PIH1 family.

9615:AHCYL1
gene id: 9615:AHCYL1
uniprot id: A0A8I3MFS0
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9615:GPR141
gene id: 9615:GPR141
uniprot id: A0A8C0SLS0
uniprot id: A0A8I3QKZ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:LOC486776
gene id: 9615:LOC486776
uniprot id: A0A8C0P500
uniprot id: A0A8I3PN69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9615:ARL17A
gene id: 9615:ARL17A
uniprot id: A0A8C0SAH7
uniprot id: A0A8I3PN02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9615:STEEP1
gene id: 9615:STEEP1
uniprot id: A0A8C0NHJ7
uniprot id: A0A8I3PIV7
names: Similarity
messages: Belongs to the STEEP1 family.

9615:SIVA1
gene id: 9615:SIVA1
uniprot id: A0A8C0MGN3
uniprot id: A0A8I3PLZ3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus

9615:CNTFR
gene id: 9615:CNTFR
uniprot id: Q71DR4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.
messages: Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).
messages: Cell membrane
messages: Expressed in retina, brain, spleen, lung, liver and kidney. In the retina it is highly expressed by photoreceptors, but also found in the RPE, inner nuclear layer and ganglion cells.
messages: Forms a heterotrimer with LIFR and IL6ST. Interacts with heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Either alone or in complex with the heterodimer CLCF1-CRLF1 interacts with SORL1; this interaction may promote internalization and lysosomal degradation.
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

9615:FOXP1
gene id: 9615:FOXP1
uniprot id: A0A8C0MJ47
uniprot id: A0A8C0MPU9
uniprot id: A0A8I3NBG2
uniprot id: A0A8I3NN58
names: Subcellular Location Annotation
messages: Nucleus

9615:LPAR3
gene id: 9615:LPAR3
uniprot id: A0A8C0RKR6
uniprot id: A0A8I3MKF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:DNAAF6
gene id: 9615:DNAAF6
uniprot id: A0A8C0TH93
uniprot id: A0A8I3P2P8
names: Similarity
messages: Belongs to the PIH1 family.

9615:GSTA4
gene id: 9615:GSTA4
uniprot id: A0A8C0NR48
uniprot id: A0A8I3NBL2
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9615:NPC1L1
gene id: 9615:NPC1L1
uniprot id: A0MJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9615:PRR5
gene id: 9615:PRR5
uniprot id: A0A8P0PL36
names: Similarity
messages: Belongs to the PROTOR family.

9615:SPACA5
gene id: 9615:SPACA5
uniprot id: A0A8C0N7J5
uniprot id: A0A8C0N7Z1
uniprot id: A0A8I3Q796
uniprot id: A0A8I3QP58
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9615:CUTA
gene id: 9615:CUTA
uniprot id: A0A8C0NDR4
uniprot id: A0A8C0QLL2
uniprot id: A0A8I3PHH4
uniprot id: A0A8I3PMV7
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9615:H4C9
gene id: 9615:H4C9
uniprot id: A0A8C0TQ44
uniprot id: F2Z4N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:CYP1A1
gene id: 9615:CYP1A1
uniprot id: A0A0U2PTV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9615:GADD45B
gene id: 9615:GADD45B
uniprot id: A0A8C0MSN2
uniprot id: A0A8I3RWN6
names: Similarity
messages: Belongs to the GADD45 family.

9615:TGFB2
gene id: 9615:TGFB2
uniprot id: A0A8C0P803
uniprot id: A0A8C0RRP5
uniprot id: A0A8I3PZZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9615:KATNAL2
gene id: 9615:KATNAL2
uniprot id: A0A8C0Q028
uniprot id: A0A8I3MLB6
uniprot id: A0A8P0SLW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

9615:FEZ2
gene id: 9615:FEZ2
uniprot id: A0A8C0MBR6
uniprot id: A0A8C0RCJ0
uniprot id: A0A8I3NTU6
uniprot id: A0A8I3P4N9
names: Similarity
messages: Belongs to the zygin family.

9615:NDUFAF1
gene id: 9615:NDUFAF1
uniprot id: A0A8C0PKK0
uniprot id: A0A8I3Q8Y3
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9615:BAAT
gene id: 9615:BAAT
uniprot id: A0A8C0RZV4
uniprot id: A0A8I3N1E1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9615:SLC25A37
gene id: 9615:SLC25A37
uniprot id: A0A8C0PE01
uniprot id: A0A8I3P7L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:KRT88
gene id: 9615:KRT88
uniprot id: A0A8I3PTR1
names: Similarity
messages: Belongs to the intermediate filament family.

9615:CHN2
gene id: 9615:CHN2
uniprot id: A0A8C0S9H2
uniprot id: A0A8I3NV41
names: Function
messages: GTPase-activating protein for p21-rac.

9615:MID2
gene id: 9615:MID2
uniprot id: A0A8C0TJL8
uniprot id: A0A8C0TNC2
uniprot id: A0A8I3S0G3
names: Subcellular Location Annotation
messages: cytoskeleton

9615:PLK2
gene id: 9615:PLK2
uniprot id: A0A8P0SCA9
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9615:CD3G
gene id: 9615:CD3G
uniprot id: A0A8C0PP31
uniprot id: A0A8I3MFY1
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Membrane
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.

9615:PITPNM1
gene id: 9615:PITPNM1
uniprot id: A0A8C0P6F2
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9615:RAB2A
gene id: 9615:RAB2A
uniprot id: P61105
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Interacts with PRKCI. Interacts with TRIP11 (By similarity). Interacts (in GTP-bound form) with GARIN1B (By similarity).
messages: Melanosome
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi.
messages: acrosome

9615:SGMS2
gene id: 9615:SGMS2
uniprot id: A0A8C0RT74
uniprot id: A0A8I3S6X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9615:CLDND2
gene id: 9615:CLDND2
uniprot id: A0A8C0PTB9
uniprot id: A0A8I3NVL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9615:DENND5A
gene id: 9615:DENND5A
uniprot id: A0A8C0YR06
uniprot id: A0A8I3NMA6
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:FKRP
gene id: 9615:FKRP
uniprot id: A0A8C0Q055
uniprot id: A0A8I3MJY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9615:TACR3
gene id: 9615:TACR3
uniprot id: A0A8C0PPR8
uniprot id: A2BCY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:GYPA
gene id: 9615:GYPA
uniprot id: P02727
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycophorin-A family.
messages: Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
messages: Homodimer. Component of the ankyrin-1 complex in the erythrocyte, composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1. Interacts with SLC4A1; a GYPA monomer is bound at each end of the SLC4A1 dimer forming an heterotetramer.
messages: Membrane

9615:CYB561A3
gene id: 9615:CYB561A3
uniprot id: A0A8C0P773
names: Subcellular Location Annotation
messages: Membrane

9615:PRUNE1
gene id: 9615:PRUNE1
uniprot id: A0A8C0SEL8
uniprot id: A0A8I3PAC2
uniprot id: A0A8I3PAL6
uniprot id: A0A8P0TTC7
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9615:MRPS18C
gene id: 9615:MRPS18C
uniprot id: A0A8P0PAQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9615:PAIP2
gene id: 9615:PAIP2
uniprot id: A0A8C0MA89
names: Similarity
messages: Belongs to the PAIP2 family.

9615:GRK6
gene id: 9615:GRK6
uniprot id: A0A8C0M5L1
uniprot id: A0A8I3NPS7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9615:ZNF397
gene id: 9615:ZNF397
uniprot id: A0A8C0S2X5
uniprot id: A0A8I3RTN6
names: Subcellular Location Annotation
messages: Nucleus

9615:CA8
gene id: 9615:CA8
uniprot id: A0A8C0NJY2
uniprot id: A0A8I3Q3R1
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9615:NSUN3
gene id: 9615:NSUN3
uniprot id: A0A8C0NWZ8
uniprot id: A0A8I3SCR6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9615:NFKB1
gene id: 9615:NFKB1
uniprot id: Q6F3J0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the NF-kappa-B p65-p50 complex (By similarity). Homodimer; component of the NF-kappa-B p50-p50 complex (By similarity). Component of the NF-kappa-B p105-p50 complex (By similarity). Component of the NF-kappa-B p50-c-Rel complex (By similarity). Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3 (By similarity). Also interacts with MAP3K8 (By similarity). NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity (By similarity). Interacts with TSC22D3; this interaction prevents nuclear translocation and DNA-binding (By similarity). Interacts with SPAG9 and UNC5CL (By similarity). NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50 (By similarity). NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2 (By similarity). Interacts with GSK3B; the interaction prevents processing of p105 to p50 (By similarity). NFKB1/p50 interacts with NFKBIE (By similarity). NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity). Directly interacts with MEN1 (By similarity). Interacts with HIF1AN (By similarity). Interacts with FEM1A; interaction is direct (By similarity).
messages: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor. Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions.
messages: Cytoplasm
messages: Generation of the NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit) transcription factor takes place both cotranslationally and post-translationally via non-mutually exclusive mechanisms. A cotranslational processing allows the production of both p50 and p105 (Nuclear factor NF-kappa-B p105 subunit) from a single NFKB1 mRNA. While translation occurs, the particular unfolded structure after the GRR repeat region acts as a substrate for the proteasome, promoting degradation of the C-terminus. The GRR acts as a proteasomal 'stop signal', protecting the region upstream of the GRR from degradation and promoting generation of p50. It is unclear if limited proteasome degradation during cotranslational processing depends on ubiquitination. NF-kappa-B p50 is also generated post-translationally following ubiquitination by the KPC complex, leading to limited processing by the proteasome downstream of the GRR region, thereby generating p50.
messages: Glycine-rich region (GRR) is a critical element in the generation of p50 (Nuclear factor NF-kappa-B p50 subunit) by acting as a proteasomal 'stop signal', which leads to limited proteasomal degradation of the C-terminus, while generating p50.
messages: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to th…
messages: Nucleus
messages: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B. Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105.
messages: Phosphorylation at the C-terminus by IKBKB/IKKB acts as a signal for ubiquitination and promotes either complete degradation or processing to generate the NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit) (By similarity). Phosphorylation at Ser-908 and Ser-912 primes p105 for proteolytic processing in response to TNF-alpha stimulation (By similarity). Phosphorylation at Ser-927, Ser-931 and Ser-936 are required for BTRC/BTRCP-mediated ubiquitination and proteolysis (By similarity). Phosphorylation at Ser-931 is also required for ubiquitination by the KPC complex and limited processing to generate NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit) (By similarity).
messages: Polyubiquitinated at multiple Lys residues in the C-terminus. Polyubiquitinated by the SCF(FBXW11) and SCF(BTRC) complexes following phosphorylation at Ser-923, Ser-927, Ser-931 and Ser-936, leading to its complete degradation. In contrast, polyubiquitination by the KPC complex following phosphorylation at Ser-931 leads to limited proteosomal processing and generation of the active NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit).
messages: S-nitrosylation of Cys-61 affects DNA binding.
messages: The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation.
messages: The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation.

9615:FUT1
gene id: 9615:FUT1
uniprot id: A0A8C0PMR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

9615:C28H10orf53
gene id: 9615:C28H10orf53
uniprot id: A0A8C0TJG2
uniprot id: A0A8I3PPE5
names: Similarity
messages: Belongs to the UPF0728 family.

9615:PAX6
gene id: 9615:PAX6
uniprot id: A0A8C0T9Q6
uniprot id: A4UHF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9615:WDR48
gene id: 9615:WDR48
uniprot id: A0A8C0N282
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Late endosome

9615:CDADC1
gene id: 9615:CDADC1
uniprot id: A0A8C0S5U7
uniprot id: A0A8I3PLW5
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9615:SDHAF2
gene id: 9615:SDHAF2
uniprot id: A0A8C0PAQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9615:UBE2R2
gene id: 9615:UBE2R2
uniprot id: A0A8C0MHX1
uniprot id: A0A8I3PHW5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:NDUFV3
gene id: 9615:NDUFV3
uniprot id: A0A8C0TU44
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

9615:GPR4
gene id: 9615:GPR4
uniprot id: A0A8C0S0P7
uniprot id: A0A8I3MW45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:CPSF2
gene id: 9615:CPSF2
uniprot id: A0A8C0LT83
uniprot id: A0A8I3PD41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9615:ATP5MG
gene id: 9615:ATP5MG
uniprot id: A0A8C0RV29
uniprot id: A0A8I3MMN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9615:LOC608051
gene id: 9615:LOC608051
uniprot id: A0A8C0PIB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:GART
gene id: 9615:GART
uniprot id: A0A8C0Z741
uniprot id: A0A8I3PRU8
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

9615:UQCRFS1
gene id: 9615:UQCRFS1
uniprot id: A0A8C0R971
uniprot id: A0A8I3MI67
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

9615:OR52P1
gene id: 9615:OR52P1
uniprot id: A0A8C0T0R3
uniprot id: A0A8I3PE66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:NAPA
gene id: 9615:NAPA
uniprot id: A0A8C0MVQ9
uniprot id: A0A8I3MLQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9615:SLC25A41
gene id: 9615:SLC25A41
uniprot id: A0A8P0TCF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:SLC35A3
gene id: 9615:SLC35A3
uniprot id: O77592
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Interacts with SLC35A2; the interaction is reduced in the presence of SLC35A4 (By similarity). Found in a complex with SLC35A2 and SLC35A4 (By similarity).
messages: Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides (By similarity).

9615:GABRA5
gene id: 9615:GABRA5
uniprot id: A0A8P0NXR2
uniprot id: A0A8P0SF22
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:PRCP
gene id: 9615:PRCP
uniprot id: A0A8C0MGB4
uniprot id: A0A8I3NNG3
names: Similarity
messages: Belongs to the peptidase S28 family.

9615:PPP1R21
gene id: 9615:PPP1R21
uniprot id: A0A8I3MZ61
uniprot id: A0A8P0NLS1
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9615:TBX4
gene id: 9615:TBX4
uniprot id: Q861Q9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs.

9615:CCL17
gene id: 9615:CCL17
uniprot id: Q95N01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation (By similarity). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity).
messages: Expressed in thymus, spleen, lymph node, lung and heart.
messages: Secreted

9615:TSR2
gene id: 9615:TSR2
uniprot id: A0A8C0P9K5
uniprot id: A0A8I3QLL6
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9615:SPDEF
gene id: 9615:SPDEF
uniprot id: A0A8C0MAB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:CWF19L1
gene id: 9615:CWF19L1
uniprot id: A0A8C0NXL7
uniprot id: A0A8C0T5W9
uniprot id: A0A8I3NP38
names: Similarity
messages: Belongs to the CWF19 family.

9615:EDNRB
gene id: 9615:EDNRB
uniprot id: P56497
uniprot id: Q9MYZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9615:SPC24
gene id: 9615:SPC24
uniprot id: A0A8C0Z0C5
uniprot id: A0A8I3PG90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9615:NPEPPS
gene id: 9615:NPEPPS
uniprot id: A0A8I3RYM4
uniprot id: A0A8P0NI33
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9615:LOC100683471
gene id: 9615:LOC100683471
uniprot id: A0A8C0LUB8
uniprot id: A0A8I3MPR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9615:APOE
gene id: 9615:APOE
uniprot id: P18649
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: APOE exists as multiple glycosylated and sialylated glycoforms within cells and in plasma. The extent of glycosylation and sialylation are tissue and context specific.
messages: APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Extracellular vesicle
messages: Glycated in plasma VLDL.
messages: Homotetramer. May interact with ABCA1; functionally associated with ABCA1 in the biogenesis of HDLs. May interact with APP/A4 amyloid-beta peptide; the interaction is extremely stable in vitro but its physiological significance is unclear. May interact with MAPT. May interact with MAP2. In the cerebrospinal fluid, interacts with secreted SORL1. Interacts with PMEL; this allows the loading of PMEL luminal fragment on ILVs to induce fibril nucleation.
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Secreted
messages: extracellular matrix
messages: extracellular space
messages: multivesicular body

9615:RPS28
gene id: 9615:RPS28
uniprot id: A0A8C0Z431
uniprot id: A0A8I3NCS3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

9615:PPP4R2
gene id: 9615:PPP4R2
uniprot id: A0A8C0NIR3
names: Similarity
messages: Belongs to the PPP4R2 family.

9615:ASPDH
gene id: 9615:ASPDH
uniprot id: A0A8C0M414
uniprot id: A0A8I3P030
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9615:VPS8
gene id: 9615:VPS8
uniprot id: A0A8C0TVB9
uniprot id: A0A8I3Q365
names: Similarity
messages: Belongs to the VPS8 family.

9615:PADI1
gene id: 9615:PADI1
uniprot id: A0A8P0SUF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9615:KCNA2
gene id: 9615:KCNA2
uniprot id: Q28293
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expressed in a wide variety of gastrointestinal smooth muscles. Not expressed in portal vein, renal artery, and uterus.
messages: Homotetramer and heterotetramer with other channel-forming alpha subunits, such as KCNA1, KCNA4, KCNA5, KCNA6 and KCNA7 (By similarity). Channel activity is regulated by interaction with the beta subunits, including KCNAB1 and KCNAB2 (By similarity). Identified in a complex with KCNA1 and KCNAB2 (By similarity). Identified in a complex with KCNA5 and KCNAB1 (By similarity). Interacts with the beta subunit KCNAB1 (By similarity). Identified in a complex with KCNA4 and FYN (By similarity). Interacts with PTK2B (By similarity). Interacts (via C-terminus) with CTTN (By similarity). Interacts (via N-terminal cytoplasmic domain) with RHOA (GTP-bound form); this regulates channel activity by reducing location at the cell surface in response to CHRM1 activation (By similarity). Interacts with DRD2 (By similarity). Interacts with SIGMAR1; cocaine consumption leads to increased interaction (By similarity). Interacts with ADAM22 (By similarity). Interacts with CNTNAP2 (By similarity). Interacts (via C-terminus) with the PDZ domains of DLG1, DLG2 and DLG4 (By similarity). Interacts with ADAM11 (By similarity).
messages: Inhibited by 4-aminopyridine (4-AP) (PubMed:8415758). Inhibited by dendrotoxin (DTX) and charybdotoxin (CTX), but not by tetraethylammonium (TEA) (By similarity). Inhibited by tityustoxin-K alpha (TsTX-Kalpha), a toxin that is highly specific for KCNA2 (By similarity). Inhibited by maurotoxin (By similarity). Inhibited by kappaM conotoxins kappaM-RIIIJ and kappaM-RIIIK (By similarity).
messages: Membrane
messages: N-glycosylated, with complex, sialylated N-glycans.
messages: Phosphorylated on tyrosine residues; phosphorylation increases in response to ischemia (By similarity). Phosphorylated on tyrosine residues by activated PTK2B/PYK2 (By similarity). Phosphorylation on tyrosine residues suppresses ion channel activity (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation; this abolishes interaction with CTTN. This is probably due to endocytosis of the phosphorylated channel subunits (By similarity). Phosphorylated on serine residues in response to increased cAMP levels; phosphorylation is apparently not catalyzed by PKA (By similarity).
messages: Presynaptic cell membrane
messages: Synapse
messages: The cytoplasmic N-terminus is important for tetramerization. Interactions between the different subunits modulate the gating characteristics (By similarity). Besides, the cytoplasmic N-terminal domain mediates interaction with RHOA and thus is required for RHOA-mediated endocytosis (By similarity).
messages: The delay or D-type current observed in hippocampus pyramidal neurons is probably mediated by potassium channels containing KCNA2 plus KCNA1 or other family members. It is activated at about -50 mV, i.e. below the action potential threshold, and is characterized by slow inactivation, extremely slow recovery from inactivation, sensitivity to dendrotoxin (DTX) and to 4-aminopyridine (4-AP).
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:8415758). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:8415758). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (By similarity). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium …
messages: axon
messages: dendrite
messages: lamellipodium membrane
messages: paranodal septate junction
messages: synaptosome

9615:GABRG1
gene id: 9615:GABRG1
uniprot id: A0A8C0RIQ2
uniprot id: A0A8I3NLX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:NDUFB5
gene id: 9615:NDUFB5
uniprot id: A0A8C0T6V7
uniprot id: A0A8I3P8G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:TMEM147
gene id: 9615:TMEM147
uniprot id: A0A8C0RUW0
uniprot id: A0A8I3MKU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM147 family.
messages: Cell membrane
messages: Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO1 and TMEM147 (PubMed:36261528). The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47) (PubMed:36261528). The MPT complex associates with the SEC61 complex (PubMed:36261528). Interacts with CHRM3, CHRM1 and AVPR2 (By similarity). Interacts with LBR; promoting LBR localization to the nucleus inner membrane (By similarity). Interacts with DHCR7 (By similarity).
messages: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261528). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261528). Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity). Regulates LBR localization to the nucleus inner membrane (By similarity).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

9615:PYCR1
gene id: 9615:PYCR1
uniprot id: A0A8I3N5F9
uniprot id: A0A8P0SBD0
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9615:ABCB11
gene id: 9615:ABCB11
uniprot id: B8K1W2
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
messages: Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:18985798). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (By similarity).
messages: Cell membrane
messages: Endosome
messages: Interacts with HAX1 (By similarity). Interacts with the adapter protein complex 2 (AP-2) throught AP2A2 or AP2A1; this interaction regulates cell membrane expression of ABCB11 through its internalization in a clathrin-dependent manner and its subsequent degradation (By similarity).
messages: Liver.
messages: N-glycosylated.
messages: Recycling endosome membrane
messages: The uptake of taurocholate is inhibited by taurolithocholate sulfate with an IC(50) of 9 uM. Pravastatin competitively inhibits the transport of taurocholic acid (PubMed:18985798). Cyclosporin A, glibenclamide, rifampicin and troglitazonestrongly competitively inhibit the transport activity of taurocholate (PubMed:18985798). The canalicular transport activity of taurocholate is strongly dependent on canalicular membrane cholesterol content. The uptake of taurocholate is increased by short- and medium-chain fatty acids. Cholesterol increases transport capacity of taurocholate without affecting the affinity for the substrate (By similarity).
messages: Ubiquitinated; short-chain ubiquitination regulates cell-Surface expression of ABCB11.

9615:BCL2L1
gene id: 9615:BCL2L1
uniprot id: A0A8C0TGM4
uniprot id: Q76LT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9615:ITGAM
gene id: 9615:ITGAM
uniprot id: A0A8C0M9J9
uniprot id: A0A8I3NIY0
uniprot id: A0A8I3NV00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:A1CF
gene id: 9615:A1CF
uniprot id: A0A8C0TIC8
uniprot id: A0A8I3PZK3
names: Subcellular Location Annotation
messages: Cytoplasm

9615:CD47
gene id: 9615:CD47
uniprot id: A0A8C0P2Q2
uniprot id: A0A8I3PHN5
uniprot id: A1Z2X6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:SSH3
gene id: 9615:SSH3
uniprot id: A0A8C0NVC0
uniprot id: A0A8I3RW57
uniprot id: A0A8P0NDM7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9615:VPS26C
gene id: 9615:VPS26C
uniprot id: A0A8C0T9X7
uniprot id: A0A8I3SBK8
names: Similarity
messages: Belongs to the VPS26 family.

9615:THRB
gene id: 9615:THRB
uniprot id: A0A8C0RRJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9615:FKTN
gene id: 9615:FKTN
uniprot id: A0A8C0NI15
uniprot id: A0A8I3NIX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9615:PCNX3
gene id: 9615:PCNX3
uniprot id: A0A8C0NDS8
uniprot id: A0A8I3P9Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9615:CCL2
gene id: 9615:CCL2
uniprot id: P52203
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). May play a significant role in monocyte trafficking into the reperfused myocardium (PubMed:9024159).
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: By TNF-alpha.
messages: Endothelium of small veins and intrafascicular veins, and infiltrating leukocytes.
messages: Monomer or homodimer; in equilibrium. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Interacts with TNFAIP6 (via Link domain).
messages: N-Glycosylated.
messages: Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity).
messages: Secreted

9615:XPC
gene id: 9615:XPC
uniprot id: A0A8C0SX48
uniprot id: A0A8I3PYW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

9615:TRPC3
gene id: 9615:TRPC3
uniprot id: A0A8C0YZ38
names: Subcellular Location Annotation
messages: Membrane

9615:MRPL19
gene id: 9615:MRPL19
uniprot id: A0A8C0QHG7
uniprot id: A0A8I3P0B6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9615:LIG3
gene id: 9615:LIG3
uniprot id: A0A8C0NM77
uniprot id: A0A8C0S6S7
uniprot id: A0A8C0S7L5
uniprot id: A0A8I3N6P7
uniprot id: A0A8I3N6S7
uniprot id: A0A8I3N6V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9615:C7H18orf25
gene id: 9615:C7H18orf25
uniprot id: A0A8C0NK19
uniprot id: A0A8C0QK23
uniprot id: A0A8I3MPF2
uniprot id: A0A8I3MUW3
names: Subcellular Location Annotation
messages: Nucleus

9615:ACTL6B
gene id: 9615:ACTL6B
uniprot id: A0A8C0YXH9
uniprot id: A0A8I3MI09
names: Similarity
messages: Belongs to the actin family.

9615:DPEP1
gene id: 9615:DPEP1
uniprot id: A0A8I3MKM8
uniprot id: A0A8P0THL7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

9615:MAB21L2
gene id: 9615:MAB21L2
uniprot id: A0A8C0NP42
uniprot id: A0A8I3N0K4
names: Similarity
messages: Belongs to the mab-21 family.

9615:BCAR1
gene id: 9615:BCAR1
uniprot id: A0A8C0LZ32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9615:TBPL1
gene id: 9615:TBPL1
uniprot id: A0A8C0PP03
uniprot id: A0A8I3MVK5
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9615:MDM4
gene id: 9615:MDM4
uniprot id: A0A8C0SPP9
uniprot id: A0A8I3PE84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

9615:SLC12A6
gene id: 9615:SLC12A6
uniprot id: A0A8C0RRJ4
uniprot id: A0A8C0RRK2
uniprot id: A0A8C0TQS1
uniprot id: A0A8I3P4U1
uniprot id: A0A8I3P9I5
uniprot id: A0A8I3S428
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9615:EIF3D
gene id: 9615:EIF3D
uniprot id: A0A8C0MP49
uniprot id: A0A8I3RUL5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9615:BCAP29
gene id: 9615:BCAP29
uniprot id: A0A8C0YXP3
uniprot id: A0A8I3S9M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9615:LMBR1
gene id: 9615:LMBR1
uniprot id: A0A8C0NSL8
uniprot id: A0A8C0YWQ7
uniprot id: A0A8I3NET2
uniprot id: A0A8I3NSL2
names: Similarity
messages: Belongs to the LIMR family.

9615:TMEM211
gene id: 9615:TMEM211
uniprot id: A0A8C0TQI5
uniprot id: A0A8I3Q1T0
names: Subcellular Location Annotation
messages: Membrane

9615:BCCIP
gene id: 9615:BCCIP
uniprot id: A0A8C0TG88
uniprot id: A0A8I3Q0V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

9615:TNF
gene id: 9615:TNF
uniprot id: A9LMQ0
uniprot id: P51742
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity).
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

9615:FYN
gene id: 9615:FYN
uniprot id: A0A8C0MFP4
uniprot id: A0A8I3NYU1
uniprot id: A0A8I3S2Y2
uniprot id: A0A8P0P4J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:CNTNAP5
gene id: 9615:CNTNAP5
uniprot id: Q0V8T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.
messages: Membrane

9615:KCNC2
gene id: 9615:KCNC2
uniprot id: A0A8C0YWW3
uniprot id: A0A8I3PSN3
uniprot id: A0A8I3S918
uniprot id: A0A8P0NSK2
names: Subcellular Location Annotation
messages: Membrane

9615:IL12A
gene id: 9615:IL12A
uniprot id: A0A8C0TCU1
uniprot id: A0A8I3PVB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.
messages: Secreted

9615:LOC612779
gene id: 9615:LOC612779
uniprot id: A0A8C0QGZ7
uniprot id: A0A8I3RQJ9
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:COMMD1
gene id: 9615:COMMD1
uniprot id: Q8WMD0
names: Disease Annotation
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Defects in COMMD1 are the cause of copper toxicosis (CT) in Bedlington terriers, a genetic disease occurring with a high prevalence worldwide and is unique to this breed. In Bedlington terriers the biliary excretion of copper is impaired.
messages: Early endosome
messages: Endosome membrane
messages: Monomer, homodimer. Can form heterodimers with other COMM domain-containing proteins but only certain combinations may exist in vivo. Interacts (via COMM domain) with COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8 and COMMD10 (via COMM domain). Identified in a complex with an E3 ubiquitin ligase complex composed of TCEB1/elongin C, CUL2, SOCS1 and RBX1; in the complex interacts directly with SOCS1 and CUL2. Interacts directly with ATP7B (via the N-terminal region). Interacts with CCS, CDKN2A, RELA, REL, RELB, NFKB1/p105, NFKB2/p100, NFKBIB, SCNN1D, SCNN1B, CFTR, CLU, SGK1, AKT1, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, CUL7, HIF1A. Identified in a complex with NF-kappa-B. Interacts directly with SLC12A2. Interacts with CCDC22 and CCDC93; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22, CCDC93. Interacts with VPS35L; the interaction associates CCC complex with retriever complex. Interacts with ATP7A. Interacts with FAM107A; this interaction stabilizes COMMD1 in the nucleus.
messages: Nucleus
messages: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1. Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner.
messages: Recycling endosome
messages: Ubiquitinated; undergoes both 'Lys-63'- and 'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation (By similarity).

9615:LOC100687441
gene id: 9615:LOC100687441
uniprot id: A0A8I3N928
names: Subcellular Location Annotation
messages: Secreted

9615:PYCR2
gene id: 9615:PYCR2
uniprot id: A0A8I3N029
uniprot id: A0A8P0SKG3
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9615:SHROOM4
gene id: 9615:SHROOM4
uniprot id: A0A8I3PT57
uniprot id: A0A8I3SAR6
uniprot id: A0A8P0NS76
uniprot id: A0A8P0P3Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9615:BFSP1
gene id: 9615:BFSP1
uniprot id: A0A8C0PHQ1
uniprot id: A0A8I3NXF2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cell cortex
messages: cytoskeleton

9615:MRPS11
gene id: 9615:MRPS11
uniprot id: A0A8I3N602
uniprot id: A0A8P0SG71
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9615:CPEB1
gene id: 9615:CPEB1
uniprot id: A0A8I3MKS6
uniprot id: A0A8P0PM22
names: Similarity
messages: Belongs to the RRM CPEB family.

9615:PMVK
gene id: 9615:PMVK
uniprot id: A0A8C0PIS1
uniprot id: A0A8I3S0N8
names: Subcellular Location Annotation
messages: cytosol

9615:POMGNT1
gene id: 9615:POMGNT1
uniprot id: A0A8C0SW67
uniprot id: A0A8I3P946
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9615:LOC102155886
gene id: 9615:LOC102155886
uniprot id: A0A8C0TJW1
uniprot id: A0A8I3NS12
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9615:GTF2A2
gene id: 9615:GTF2A2
uniprot id: A0A8C0N187
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9615:AKAP3
gene id: 9615:AKAP3
uniprot id: A0A8C0TNW3
names: Similarity
messages: Belongs to the AKAP110 family.

9615:GJB4
gene id: 9615:GJB4
uniprot id: A0A8C0NMW0
uniprot id: A0A8I3P1D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:HTRA2
gene id: 9615:HTRA2
uniprot id: A0A8C0RNJ0
uniprot id: Q45FF7
names: Similarity
messages: Belongs to the peptidase S1C family.

9615:ZDHHC3
gene id: 9615:ZDHHC3
uniprot id: A0A8I3NP90
uniprot id: A0A8P0T3M6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:NUPR1
gene id: 9615:NUPR1
uniprot id: A0A8C0Q1Q4
uniprot id: A0A8I3RS39
names: Similarity
messages: Belongs to the NUPR family.

9615:MRPS7
gene id: 9615:MRPS7
uniprot id: A0A8C0M861
uniprot id: A0A8I3Q0A8
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9615:TWF1
gene id: 9615:TWF1
uniprot id: A0A8C0TGD9
uniprot id: A0A8I3QIT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9615:MFSD5
gene id: 9615:MFSD5
uniprot id: A0A8C0TH98
uniprot id: A0A8I3S251
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
messages: Membrane

9615:NTHL1
gene id: 9615:NTHL1
uniprot id: A0A8C0LQR6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Interacts with YBX1.
messages: Mitochondrion
messages: Nucleus

9615:BNIP3
gene id: 9615:BNIP3
uniprot id: Q005W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9615:NUDT12
gene id: 9615:NUDT12
uniprot id: A0A8C0RHH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

9615:LOC100856725
gene id: 9615:LOC100856725
uniprot id: A0A8C0PRC5
names: Similarity
messages: Belongs to the PRORSD1 family.

9615:OPRK1
gene id: 9615:OPRK1
uniprot id: A0A0F6TN93
uniprot id: A0A8C0P2B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with NHERF1. Interacts with GABARAPL1.
messages: Membrane

9615:SPATS2L
gene id: 9615:SPATS2L
uniprot id: A0A8I3PW51
uniprot id: A0A8P0SZ23
names: Similarity
messages: Belongs to the SPATS2 family.

9615:PPP6C
gene id: 9615:PPP6C
uniprot id: A0A8C0TEA3
uniprot id: A0A8I3NCZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9615:PNPLA1
gene id: 9615:PNPLA1
uniprot id: A0A8P0N4J4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SDC1
gene id: 9615:SDC1
uniprot id: A0A8C0NCG9
uniprot id: A0A8I3P4F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9615:AFG1L
gene id: 9615:AFG1L
uniprot id: A0A8C0S658
uniprot id: A0A8I3NDZ0
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9615:ITGA1
gene id: 9615:ITGA1
uniprot id: A0A8C0S0A1
uniprot id: A0A8I3MAW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:CALCRL
gene id: 9615:CALCRL
uniprot id: A0A8C0MVR4
uniprot id: A0A8I3NWR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9615:LOC751814
gene id: 9615:LOC751814
uniprot id: P19708
names: Disease Annotation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SAA family.
messages: Expressed by the liver; secreted in plasma.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.
messages: Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
messages: Secreted
messages: This protein is the precursor of amyloid protein A, which is formed by the removal of residues from the C-terminal end.
messages: Upon cytokine stimulation.

9615:SLC7A3
gene id: 9615:SLC7A3
uniprot id: A0A8P0NI56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9615:PIEZO1
gene id: 9615:PIEZO1
uniprot id: A0A8P0NKW1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIEZO (TC 1.A.75) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:BABAM2
gene id: 9615:BABAM2
uniprot id: A0A8C0SHX9
uniprot id: A0A8I3N946
uniprot id: A0A8I3NA35
uniprot id: A0A8P0T694
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

9615:LOC491550
gene id: 9615:LOC491550
uniprot id: A0A8C0NCJ9
names: Similarity
messages: Belongs to the threonine aldolase family.

9615:SHOX
gene id: 9615:SHOX
uniprot id: A0A8C0S8L3
uniprot id: A0A8I3P677
names: Subcellular Location Annotation
messages: Nucleus

9615:SUMF1
gene id: 9615:SUMF1
uniprot id: A0A8C0QBH7
uniprot id: A0A8I3NK85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9615:DDX3X
gene id: 9615:DDX3X
uniprot id: A0A8C0YWQ4
uniprot id: A0A8P0P611
names: Similarity
messages: Belongs to the DEAD box helicase family.

9615:SPI1
gene id: 9615:SPI1
uniprot id: A0A8C0QIT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:PRDM10
gene id: 9615:PRDM10
uniprot id: A0A8C0M652
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9615:CCK
gene id: 9615:CCK
uniprot id: A0A8C0NBZ7
uniprot id: A0A8I3S0Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

9615:DLA-DOA
gene id: 9615:DLA-DOA
uniprot id: A0A8C0RK32
uniprot id: Q5TJG5
names: Similarity
messages: Belongs to the MHC class II family.

9615:ACYP1
gene id: 9615:ACYP1
uniprot id: A0A8C0NNQ5
uniprot id: A0A8I3NZF1
names: Similarity
messages: Belongs to the acylphosphatase family.

9615:SLC39A2
gene id: 9615:SLC39A2
uniprot id: A0A8C0ML99
uniprot id: A0A8I3PWH1
names: Subcellular Location Annotation
messages: Membrane

9615:LOC487015
gene id: 9615:LOC487015
uniprot id: A0A8C0N2F3
uniprot id: A0A8I3NW25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9615:CCL28
gene id: 9615:CCL28
uniprot id: Q68A91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner (By similarity).
messages: Secreted

9615:SRFBP1
gene id: 9615:SRFBP1
uniprot id: A0A8I3N2Q8
uniprot id: A0A8P0S6Q6
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9615:KCNJ2
gene id: 9615:KCNJ2
uniprot id: H8F4N3
uniprot id: Q9MYY9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity).
messages: Membrane
messages: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked by external barium or cesium (By similarity).
messages: S-nitrosylation increases the open probability and inward rectifying currents.

9615:SEMA4C
gene id: 9615:SEMA4C
uniprot id: A0A8C0T0R4
uniprot id: A0A8I3PFL0
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:DKK2
gene id: 9615:DKK2
uniprot id: A0A8C0TBE6
uniprot id: A0A8I3QQD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9615:PITX2
gene id: 9615:PITX2
uniprot id: A0A8C0PL96
uniprot id: A0A8C0TNV7
uniprot id: A0A8C0TTG9
uniprot id: A0A8I3NVW1
uniprot id: A0A8I3NZC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9615:FGF14
gene id: 9615:FGF14
uniprot id: A0A8C0M8L5
uniprot id: A0A8I3PYP1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:DLX3
gene id: 9615:DLX3
uniprot id: A0A8C0LWI6
uniprot id: A0A8I3RWQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9615:MAP3K5
gene id: 9615:MAP3K5
uniprot id: A0A8C0RVK6
uniprot id: A0A8I3RT53
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9615:TNKS2
gene id: 9615:TNKS2
uniprot id: A0A8C0Z1D4
names: Function
names: Similarity
messages: Belongs to the ARTD/PARP family.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9615:PKIA
gene id: 9615:PKIA
uniprot id: A0A8C0RIW6
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9615:SEZ6
gene id: 9615:SEZ6
uniprot id: A0A8P0NPZ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:IFGGC1
gene id: 9615:IFGGC1
uniprot id: A0A5K1TXL6
uniprot id: A0A8C0Q9X8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9615:P2RY2
gene id: 9615:P2RY2
uniprot id: A0A8C0N8F9
uniprot id: A0A8I3MZ62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:NUDT17
gene id: 9615:NUDT17
uniprot id: A0A8I3RY69
uniprot id: A0A8P0SG99
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

9615:GTF2H3
gene id: 9615:GTF2H3
uniprot id: A0A8C0TNI3
uniprot id: A0A8I3P3S7
uniprot id: A0A8I3P9S2
uniprot id: A0A8P0PSQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

9615:VDAC2
gene id: 9615:VDAC2
uniprot id: A0A8C0P0B2
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

9615:MC5R
gene id: 9615:MC5R
uniprot id: A0A8P0N3F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

9615:PPOX
gene id: 9615:PPOX
uniprot id: A0A8C0SK32
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

9615:ADH4
gene id: 9615:ADH4
uniprot id: A0A8C0P4S6
uniprot id: A0A8I3PLN9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9615:DYNLRB2
gene id: 9615:DYNLRB2
uniprot id: A0A8C0LVS6
uniprot id: A0A8I3PEX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9615:MMP12
gene id: 9615:MMP12
uniprot id: A0A8C0Z2Z1
uniprot id: A0A8I3MBX9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9615:USP15
gene id: 9615:USP15
uniprot id: A0A8C0RCM8
uniprot id: A0A8C0Z1Q3
uniprot id: A0A8I3N252
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9615:DONSON
gene id: 9615:DONSON
uniprot id: A0A8C0MPA1
uniprot id: A0A8I3PLX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

9615:SRP19
gene id: 9615:SRP19
uniprot id: A0A8C0NFD3
uniprot id: J9PAS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with IPO5, IPO7, IPO8, KPNB1 and TNPO1. Interactions with IPO8 and TNPO1 may be involved in SRP19 import into the nucleus (By similarity).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6938958, PubMed:6413076). Binds directly to 7SL RNA (PubMed:6413076). Mediates binding of SRP54 to the SRP complex (PubMed:6413076).
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9615:SMDT1
gene id: 9615:SMDT1
uniprot id: A0A8C0RSL9
uniprot id: A0A8I3NVN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9615:TPP1
gene id: 9615:TPP1
uniprot id: Q9XSB8
names: Cofactor
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity (By similarity).
messages: Binds 1 Ca(2+) ion per subunit.
messages: Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).
messages: Lysosome
messages: Melanosome
messages: Monomer. Interacts with CLN5. Interacts with CLN3 (By similarity).

9615:PTPN4
gene id: 9615:PTPN4
uniprot id: A0A8C0P7K7
uniprot id: A0A8I3PVT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9615:CDC42BPG
gene id: 9615:CDC42BPG
uniprot id: A0A8P0NFS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm

9615:MIX23
gene id: 9615:MIX23
uniprot id: A0A8C0TKH2
names: Similarity
messages: Belongs to the MIX23 family.

9615:VCAM1
gene id: 9615:VCAM1
uniprot id: Q28260
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.
messages: Cell membrane
messages: Cleaved by the metalloproteinase ADAM17 to generate the soluble form.
messages: Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
messages: Secreted
messages: Sialoglycoprotein.
messages: Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination; leading to proteasomal degradation.

9615:ESF1
gene id: 9615:ESF1
uniprot id: A0A8C0NPE8
uniprot id: A0A8I3PPA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

9615:PLA2G2D
gene id: 9615:PLA2G2D
uniprot id: A0A8I3MN96
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9615:CYLD
gene id: 9615:CYLD
uniprot id: A0A8C0RFJ2
uniprot id: A0A8I3MLG1
uniprot id: A0A8I3MSL4
uniprot id: A0A8P0P0W3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9615:CDKN2AIPNL
gene id: 9615:CDKN2AIPNL
uniprot id: A0A8C0QDY2
uniprot id: A0A8I3RZQ6
names: Similarity
messages: Belongs to the CARF family.

9615:SLC17A7
gene id: 9615:SLC17A7
uniprot id: A0A8C0T402
uniprot id: A0A8I3PN97
names: Subcellular Location Annotation
messages: Membrane

9615:LOC102151683
gene id: 9615:LOC102151683
uniprot id: A0A8C0MC36
uniprot id: A0A8I3P1P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

9615:FYTTD1
gene id: 9615:FYTTD1
uniprot id: A0A8C0NUT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle
messages: nucleoplasm

9615:SLC39A12
gene id: 9615:SLC39A12
uniprot id: A0A8C0N0D1
uniprot id: A0A8C0NE34
uniprot id: A0A8I3NMK0
uniprot id: A0A8I3P0B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9615:VEGFA
gene id: 9615:VEGFA
uniprot id: Q9MYV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
messages: Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (By similarity). Interacts with BSG (By similarity).
messages: Secreted

9615:OR13E1
gene id: 9615:OR13E1
uniprot id: A0A8C0MPP9
uniprot id: A0A8I3NAF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:MYADM
gene id: 9615:MYADM
uniprot id: A0A8C0M020
uniprot id: J9NYK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9615:TIMM9
gene id: 9615:TIMM9
uniprot id: A0A8C0R9T4
uniprot id: A0A8I3PDA9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9615:CLCN4
gene id: 9615:CLCN4
uniprot id: A0A8C0YYL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9615:ADCY8
gene id: 9615:ADCY8
uniprot id: A0A8C0T467
uniprot id: A0A8C0T647
uniprot id: A0A8C0Z1L3
uniprot id: A0A8I3NFX0
uniprot id: A0A8I3NUA5
uniprot id: A0A8I3NUB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9615:LOC100855683
gene id: 9615:LOC100855683
uniprot id: A0A8C0M657
uniprot id: A0A8I3NI34
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.

9615:LHB
gene id: 9615:LHB
uniprot id: A0A0F7RQ31
uniprot id: A0A8C0ND35
uniprot id: P18842
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
messages: Secreted

9615:UTP6
gene id: 9615:UTP6
uniprot id: A0A8C0RNV3
uniprot id: A0A8I3NST8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

9615:P4HA3
gene id: 9615:P4HA3
uniprot id: A0A8C0T2Z9
uniprot id: A0A8I3MSQ5
uniprot id: A0A8I3N373
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9615:LIPG
gene id: 9615:LIPG
uniprot id: A0A8C0LYV5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:RELT
gene id: 9615:RELT
uniprot id: A0A8C0NCP4
uniprot id: A0A8C0SS11
uniprot id: A0A8I3NAK0
uniprot id: A0A8I3NJQ8
uniprot id: A0A8P0P6E4
names: Caution
names: Similarity
messages: Belongs to the RELT family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:FDPS
gene id: 9615:FDPS
uniprot id: A0A8C0PL88
uniprot id: A0A8I3NF82
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9615:PPARGC1A
gene id: 9615:PPARGC1A
uniprot id: A0A8C0M294
uniprot id: A0A8C0M3T2
uniprot id: A0A8I3RUL9
names: Subcellular Location Annotation
messages: PML body

9615:FH
gene id: 9615:FH
uniprot id: A0A8C0NZZ1
uniprot id: A0A8I3MXC4
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9615:CCL24
gene id: 9615:CCL24
uniprot id: Q68Y86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.
messages: Secreted

9615:NIBAN1
gene id: 9615:NIBAN1
uniprot id: A0A8P0NF80
uniprot id: A0A8P0STA6
uniprot id: A0A8P0T9Z6
names: Similarity
messages: Belongs to the Niban family.

9615:PLCB4
gene id: 9615:PLCB4
uniprot id: A0A8C0QFL9
uniprot id: A0A8C0QHI2
uniprot id: A0A8I3PUW3
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9615:SMAD3
gene id: 9615:SMAD3
uniprot id: D2YYC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9615:TUBG1
gene id: 9615:TUBG1
uniprot id: Q9GKK5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Interacts with TUBGCP2, TUBGCP3 and B9D2 (By similarity). Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with CIMAP3. Interacts with SAS6 and NUP62 at the centrosome (By similarity). Interacts with EML3 (phosphorylated form) and HAUS8 (By similarity).
messages: Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).
messages: centrosome
messages: spindle

9615:NAP1L5
gene id: 9615:NAP1L5
uniprot id: A0A8C0SSR9
uniprot id: A0A8I3P5G7
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9615:BBS5
gene id: 9615:BBS5
uniprot id: A0A8C0TYA2
uniprot id: A0A8I3PED7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9615:MAL
gene id: 9615:MAL
uniprot id: Q28296
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.
messages: Lipoprotein.
messages: Membrane

9615:RIMKLA
gene id: 9615:RIMKLA
uniprot id: A0A8C0RRR9
names: Similarity
messages: Belongs to the RimK family.

9615:MAPRE3
gene id: 9615:MAPRE3
uniprot id: A0A8C0MH41
uniprot id: A0A8I3N134
uniprot id: A0A8I3N1W1
uniprot id: A0A8P0TJK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9615:EMX2
gene id: 9615:EMX2
uniprot id: A0A8C0PCR1
uniprot id: A0A8I3QCL1
names: Subcellular Location Annotation
messages: Nucleus

9615:COPS4
gene id: 9615:COPS4
uniprot id: A0A8C0Z5P5
uniprot id: A0A8I3P5Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9615:RBP2
gene id: 9615:RBP2
uniprot id: A0A8C0Q2M0
uniprot id: A0A8I3QDC6
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9615:PRICKLE2
gene id: 9615:PRICKLE2
uniprot id: A0A8C0N575
uniprot id: A0A8I3NE98
uniprot id: A0A8I3NK07
uniprot id: A0A8P0T309
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9615:CRELD1
gene id: 9615:CRELD1
uniprot id: A0A8C0TPX3
uniprot id: A0A8I3N8T9
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:BRINP3
gene id: 9615:BRINP3
uniprot id: A0A8C0RS47
uniprot id: A0A8I3PMY2
names: Similarity
messages: Belongs to the BRINP family.

9615:XIAP
gene id: 9615:XIAP
uniprot id: A0A8C0T2T5
uniprot id: Q38IV1
names: Similarity
messages: Belongs to the IAP family.

9615:MC1R
gene id: 9615:MC1R
uniprot id: M1R1N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

9615:EIF1
gene id: 9615:EIF1
uniprot id: A0A8C0YUG5
uniprot id: A0A8I3NWE5
names: Similarity
messages: Belongs to the SUI1 family.

9615:NGB
gene id: 9615:NGB
uniprot id: Q6WZ18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the globin family.
messages: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes (By similarity).
messages: Monomer. Homodimer and homotetramer; disulfide-linked.
messages: Perikaryon

9615:AADACL3
gene id: 9615:AADACL3
uniprot id: A0A8C0Q290
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9615:LDB3
gene id: 9615:LDB3
uniprot id: A0A8C0S782
uniprot id: A0A8I3NFE0
names: Subcellular Location Annotation
messages: Z line

9615:KRTCAP2
gene id: 9615:KRTCAP2
uniprot id: P86229
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRTCAP2 family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:15835887). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (Probable). Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex (By similarity).
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9615:PDE4D
gene id: 9615:PDE4D
uniprot id: A0A8C0LU39
uniprot id: A0A8C0LUJ9
uniprot id: A0A8C0LXG4
uniprot id: A0A8C0LXT1
uniprot id: A0A8C0M490
uniprot id: A0A8C0PVI8
uniprot id: A0A8C0RA18
uniprot id: A0A8I3MZQ9
uniprot id: A0A8I3N1Y7
uniprot id: A0A8I3N391
uniprot id: A0A8I3N583
uniprot id: A0A8I3N5K5
uniprot id: A0A8I3N803
uniprot id: A0A8I3RTU1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:NRN1
gene id: 9615:NRN1
uniprot id: A0A8C0YX63
uniprot id: A0A8I3P2X9
names: Similarity
messages: Belongs to the neuritin family.

9615:NEXMIF
gene id: 9615:NEXMIF
uniprot id: A0A8C0MZQ2
uniprot id: A0A8I3Q8D0
names: Subcellular Location Annotation
messages: Nucleus

9615:GNPAT
gene id: 9615:GNPAT
uniprot id: A0A8C0NIX2
uniprot id: A0A8I3MC36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9615:SRP14
gene id: 9615:SRP14
uniprot id: P16255
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6938958). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (PubMed:6938958, PubMed:6413076). The complex of SRP9 and SRP14 is required for SRP RNA binding (PubMed:6938958, PubMed:6413076).
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer (PubMed:6413076). Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:6938958, PubMed:6413076).

9615:CEBPB
gene id: 9615:CEBPB
uniprot id: A0A8I3Q8Y2
uniprot id: A0A8P0SRV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9615:SDHB
gene id: 9615:SDHB
uniprot id: A0A8C0RFS0
uniprot id: A0A8I3MX02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9615:PKIG
gene id: 9615:PKIG
uniprot id: A0A8C0TRK8
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9615:DUOX1
gene id: 9615:DUOX1
uniprot id: Q9MZF4
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: By forskolin (at protein level). By thyrotropin.
messages: Expressed in thyrocytes (at protein level). Specifically expressed in thyroid.
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Interacts with TPO and CYBA (By similarity). Interacts with TXNDC11.
messages: N-glycosylated.
messages: Peroxidase activity is inhibited by aminobenzohydrazide (By similarity). The NADPH oxidase activity is calcium-dependent.

9615:ASXL1
gene id: 9615:ASXL1
uniprot id: A0A8P0PC91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9615:SPEM1
gene id: 9615:SPEM1
uniprot id: A0A8C0RK63
uniprot id: A0A8I3PJ93
names: Subcellular Location Annotation
messages: Membrane

9615:ATL3
gene id: 9615:ATL3
uniprot id: A0A8C0MPZ3
uniprot id: A0A8I3MUQ3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9615:MCMBP
gene id: 9615:MCMBP
uniprot id: A0A8C0PFL2
uniprot id: A0A8I3NV32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

9615:CYP26A1
gene id: 9615:CYP26A1
uniprot id: A0A8C0Z3N5
uniprot id: A0A8I3P076
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:HKDC1
gene id: 9615:HKDC1
uniprot id: A0A8C0NLX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9615:CNTF
gene id: 9615:CNTF
uniprot id: A0A8P0NA50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

9615:SPOP
gene id: 9615:SPOP
uniprot id: A0A8C0LUP5
uniprot id: A0A8I3RYG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9615:LIM2
gene id: 9615:LIM2
uniprot id: A0A8C0Q1H6
uniprot id: A0A8I3MYZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.

9615:TMEM126A
gene id: 9615:TMEM126A
uniprot id: A0A8C0MQU2
uniprot id: A0A8I3N8M5
names: Subcellular Location Annotation
messages: Membrane

9615:NRXN1
gene id: 9615:NRXN1
uniprot id: A0A8C0REN0
uniprot id: A0A8C0REQ8
uniprot id: A0A8C0SP61
uniprot id: A0A8I3N2C2
uniprot id: A0A8I3N5M6
uniprot id: A0A8I3RV85
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Presynaptic cell membrane

9615:ATP2C2
gene id: 9615:ATP2C2
uniprot id: A0A8C0LVL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:PRND
gene id: 9615:PRND
uniprot id: A0A8C0YRG9
uniprot id: A0A8I3PYZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9615:TAC1
gene id: 9615:TAC1
uniprot id: A0A8P0S808
uniprot id: A0A8P0S827
uniprot id: A0A8P0T7M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9615:AURKAIP1
gene id: 9615:AURKAIP1
uniprot id: A0A8C0PYU5
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mS38 family.

9615:CA13
gene id: 9615:CA13
uniprot id: A0A8C0N142
uniprot id: A0A8I3NR66
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9615:KIF22
gene id: 9615:KIF22
uniprot id: A0A8C0M0Z5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:HBEGF
gene id: 9615:HBEGF
uniprot id: A0A8C0MA18
uniprot id: A0A8C0PXH1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:KRT12
gene id: 9615:KRT12
uniprot id: A3RF35
names: Similarity
messages: Belongs to the intermediate filament family.

9615:CLUH
gene id: 9615:CLUH
uniprot id: A0A8C0N278
uniprot id: A0A8P0NWB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

9615:B3GALT1
gene id: 9615:B3GALT1
uniprot id: A0A8C0TY66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:NSFL1C
gene id: 9615:NSFL1C
uniprot id: A0A8C0T4Z7
uniprot id: A0A8I3NXH4
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

9615:GATM
gene id: 9615:GATM
uniprot id: A0A8C0NC71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain.

9615:DDX10
gene id: 9615:DDX10
uniprot id: A0A8C0NXQ0
uniprot id: A0A8C0SB06
uniprot id: A0A8I3MV30
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9615:FAM229A
gene id: 9615:FAM229A
uniprot id: A0A8I3MTV1
uniprot id: A0A8P0TL13
names: Similarity
messages: Belongs to the FAM229 family.

9615:CPT1C
gene id: 9615:CPT1C
uniprot id: A0A8C0SVR6
uniprot id: A0A8I3PFF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:TEKT4
gene id: 9615:TEKT4
uniprot id: A0A8I3PMH2
uniprot id: A0A8P0NKS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9615:BSX
gene id: 9615:BSX
uniprot id: A0A8C0LZU5
uniprot id: A0A8I3NND9
names: Subcellular Location Annotation
messages: Nucleus

9615:GUSB
gene id: 9615:GUSB
uniprot id: O18835
names: Activity Regulation
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Defects in GUSB are the cause of mucopolysaccharidosis type VII (MPS VII), an inherited disease reported in humans, mice, cats, and dogs.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

9615:SLC6A17
gene id: 9615:SLC6A17
uniprot id: A0A8C0NQK0
uniprot id: A0A8I3MEZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9615:DPP3
gene id: 9615:DPP3
uniprot id: A0A8C0NJ31
uniprot id: A0A8P0SH85
uniprot id: A0A8P0TSG1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

9615:ADORA2B
gene id: 9615:ADORA2B
uniprot id: Q6W3F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).

9615:MGMT
gene id: 9615:MGMT
uniprot id: Q6TDU1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Binds 1 zinc ion.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: Nucleus
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

9615:ESRRA
gene id: 9615:ESRRA
uniprot id: Q6QMY5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transcriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation. Interacts with MAPK15; promotes re-localization of ESRRA to the cytoplasm through a XPO1-dependent mechanism then inhibits ESRRA transcriptional activity.
messages: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. May function as a modulator of the estrogen signaling pathway in the uterus. Induces the expression of PERM1 in the skeletal muscle (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.
messages: Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding (By similarity).
messages: Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding (By similarity).

9615:IRF6
gene id: 9615:IRF6
uniprot id: A0A8C0T0U5
uniprot id: A0A8I3MM71
names: Subcellular Location Annotation
messages: Nucleus

9615:CYP4A11
gene id: 9615:CYP4A11
uniprot id: Q2VHZ7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:IMP3
gene id: 9615:IMP3
uniprot id: A0A8C0MSU6
uniprot id: A0A8I3PD02
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9615:PAQR9
gene id: 9615:PAQR9
uniprot id: A0A8C0MDJ5
uniprot id: A0A8I3Q0L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9615:ELK3
gene id: 9615:ELK3
uniprot id: A0A8C0RZ25
uniprot id: A0A8I3PXT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:GNB1
gene id: 9615:GNB1
uniprot id: P62872
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity). Forms a complex with GNAO1 and GNG3. Interacts with ARHGEF18 and RASD2 (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.

9615:RNGTT
gene id: 9615:RNGTT
uniprot id: A0A8I3N0K0
uniprot id: A0A8P0N624
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

9615:SDHC
gene id: 9615:SDHC
uniprot id: A0A8I3QQW6
uniprot id: A0A8P0PKR7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9615:PRODH2
gene id: 9615:PRODH2
uniprot id: A0A8C0MTA1
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

9615:PRPF3
gene id: 9615:PRPF3
uniprot id: A0A8C0MGA6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9615:PHPT1
gene id: 9615:PHPT1
uniprot id: A0A8C0SLX4
uniprot id: A0A8I3MSR7
names: Function
names: Similarity
messages: Belongs to the janus family.
messages: Exhibits phosphohistidine phosphatase activity.

9615:YPEL3
gene id: 9615:YPEL3
uniprot id: A0A8C0LZ46
uniprot id: A0A8I3MJ16
names: Similarity
messages: Belongs to the yippee family.

9615:TDRD5
gene id: 9615:TDRD5
uniprot id: A0A8P0SIS1
uniprot id: A0A8P0TFP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDRD5 family.
messages: Cytoplasm
messages: Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly.

9615:PTGER2
gene id: 9615:PTGER2
uniprot id: Q9XT82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle (By similarity).

9615:RRP8
gene id: 9615:RRP8
uniprot id: A0A8C0RF14
uniprot id: A0A8I3RUP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Component of the eNoSC complex.
messages: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.
messages: nucleolus

9615:CCND3
gene id: 9615:CCND3
uniprot id: A0A8C0MF30
uniprot id: A0A8I3NNP3
names: Similarity
messages: Belongs to the cyclin family.

9615:IKBKB
gene id: 9615:IKBKB
uniprot id: A0A8I3N4F2
uniprot id: A0A8P0SB22
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:EGR1
gene id: 9615:EGR1
uniprot id: A0A8C0SPV5
uniprot id: A0A8I3PHY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9615:HOXA2
gene id: 9615:HOXA2
uniprot id: A0A8C0RDE8
uniprot id: A0A8I3NDA0
names: Subcellular Location Annotation
messages: Nucleus

9615:MYH8
gene id: 9615:MYH8
uniprot id: Q076A4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9615:ADD1
gene id: 9615:ADD1
uniprot id: A0A8P0NZE9
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9615:OR7A63
gene id: 9615:OR7A63
uniprot id: A0A8P0STD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:PTN
gene id: 9615:PTN
uniprot id: A0A8C0SSP7
uniprot id: A0A8I3N6G8
names: Similarity
messages: Belongs to the pleiotrophin family.

9615:WFDC2
gene id: 9615:WFDC2
uniprot id: Q28894
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Broad range protease inhibitor (By similarity). Possible function in sperm maturation.
messages: Epididymis. Highest levels are found in the caput and proximal cauda regions. Lower levels in the distal cauda. Not detected in the efferent ducts.
messages: Homotrimer; disulfide-linked.
messages: Secreted

9615:SF3B6
gene id: 9615:SF3B6
uniprot id: A0A8C0QGX1
uniprot id: A0A8I3PC35
names: Subcellular Location Annotation
messages: Nucleus

9615:UQCC3
gene id: 9615:UQCC3
uniprot id: A0A8C0MI20
uniprot id: A0A8I3N4J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9615:SUPT5H
gene id: 9615:SUPT5H
uniprot id: A0A8C0SID0
uniprot id: A0A8C0SIG6
uniprot id: A0A8I3MSR1
uniprot id: A0A8I3RS47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9615:METTL8
gene id: 9615:METTL8
uniprot id: A0A8C0NCV5
uniprot id: A0A8I3PTX1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9615:OSMR
gene id: 9615:OSMR
uniprot id: A0A8P0NJS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9615:CHST12
gene id: 9615:CHST12
uniprot id: A0A8C0MJK2
uniprot id: A0A8I3MZM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:AGBL4
gene id: 9615:AGBL4
uniprot id: A0A8C0SGE7
uniprot id: A0A8I3PWL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9615:TAS2R7
gene id: 9615:TAS2R7
uniprot id: A0A8C0NTV0
uniprot id: Q2ABD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:PSENEN
gene id: 9615:PSENEN
uniprot id: A0A8C0MHU8
uniprot id: J9P0J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9615:POU4F3
gene id: 9615:POU4F3
uniprot id: A0A8C0RC23
uniprot id: A0A8I3PMT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9615:DISP3
gene id: 9615:DISP3
uniprot id: A0A8I3RS74
uniprot id: A0A8P0SKM7
names: Subcellular Location Annotation
messages: Membrane

9615:THUMPD2
gene id: 9615:THUMPD2
uniprot id: A0A8C0TY28
uniprot id: A0A8I3PJ71
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9615:CYBB
gene id: 9615:CYBB
uniprot id: A0A8C0SUZ1
uniprot id: A7E3K7
names: Subcellular Location Annotation
messages: Membrane

9615:IFNGR1
gene id: 9615:IFNGR1
uniprot id: A0A8C0M1P1
uniprot id: A0A8I3MY73
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9615:JPH1
gene id: 9615:JPH1
uniprot id: A0A8C0RJC9
uniprot id: A0A8I3QHX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9615:SLC26A2
gene id: 9615:SLC26A2
uniprot id: A0A8C0LYQ1
uniprot id: A0A8I3RUU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion.

9615:UQCRC2
gene id: 9615:UQCRC2
uniprot id: A0A8C0P0Z5
uniprot id: A0A8I3MM40
names: Similarity
messages: Belongs to the peptidase M16 family.

9615:LPGAT1
gene id: 9615:LPGAT1
uniprot id: A0A8C0T354
uniprot id: A0A8I3MQL2
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9615:LOC488190
gene id: 9615:LOC488190
uniprot id: A0A8C0MNJ5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:SLC44A2
gene id: 9615:SLC44A2
uniprot id: A0A8C0NVP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9615:SMC5
gene id: 9615:SMC5
uniprot id: A0A8C0NIZ8
uniprot id: A0A8C0NMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

9615:HAUS1
gene id: 9615:HAUS1
uniprot id: A0A8P0SW24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9615:MTFR1L
gene id: 9615:MTFR1L
uniprot id: A0A8C0NIQ3
uniprot id: A0A8I3NRG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9615:LOC491028
gene id: 9615:LOC491028
uniprot id: A0A8I3NFQ9
uniprot id: A0A8P0NWE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9615:POMT1
gene id: 9615:POMT1
uniprot id: A0A8P0SNS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9615:OR51R1
gene id: 9615:OR51R1
uniprot id: A0A8C0NW51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:COX17
gene id: 9615:COX17
uniprot id: Q6J3Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COX17 family.
messages: Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
messages: Cytoplasm
messages: Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure.
messages: Mitochondrion intermembrane space

9615:STX18
gene id: 9615:STX18
uniprot id: A0A8C0SPU6
uniprot id: A0A8C0SR93
uniprot id: A0A8I3ML77
uniprot id: A0A8I3N4G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

9615:SUMF2
gene id: 9615:SUMF2
uniprot id: A0A8I3NQ68
uniprot id: A0A8P0SF05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9615:PDZK1IP1
gene id: 9615:PDZK1IP1
uniprot id: A0A8P0S9P9
names: Subcellular Location Annotation
messages: Membrane

9615:C21H11orf54
gene id: 9615:C21H11orf54
uniprot id: A0A8I3S218
uniprot id: A0A8I3S4N7
uniprot id: A0A8P0N738
uniprot id: A0A8P0NZG3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9615:CACNA1D
gene id: 9615:CACNA1D
uniprot id: A0A8C0T2Q3
uniprot id: A0A8C0T2W3
uniprot id: A0A8C0T3X3
uniprot id: A0A8C0Z1I5
uniprot id: A0A8I3PVS0
uniprot id: A0A8I3PVT8
uniprot id: A0A8I3PW57
uniprot id: A0A8I3Q2Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9615:DBH
gene id: 9615:DBH
uniprot id: Q68CI2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Binds 2 copper ions per subunit.
messages: Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.
messages: Homotetramer; composed of two disulfide-linked dimers.
messages: N-glycosylated.
messages: Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form.
messages: Secreted
messages: chromaffin granule lumen
messages: chromaffin granule membrane
messages: secretory vesicle lumen
messages: secretory vesicle membrane

9615:KCNH8
gene id: 9615:KCNH8
uniprot id: A0A8C0PLC3
uniprot id: A0A8I3PNB9
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9615:ELL2
gene id: 9615:ELL2
uniprot id: A0A8C0PPD9
uniprot id: A0A8I3P0L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9615:BAZ1A
gene id: 9615:BAZ1A
uniprot id: A0A8C0MMS2
uniprot id: A0A8C0SR45
uniprot id: A0A8I3ME85
uniprot id: A0A8I3MM15
names: Subcellular Location Annotation
messages: Nucleus

9615:GLB1L
gene id: 9615:GLB1L
uniprot id: A0A8C0RH93
uniprot id: A0A8I3Q139
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9615:ATAD2
gene id: 9615:ATAD2
uniprot id: A0A8C0REJ2
uniprot id: A0A8I3NNM9
names: Similarity
messages: Belongs to the AAA ATPase family.

9615:MLLT3
gene id: 9615:MLLT3
uniprot id: A0A8P0N4S5
uniprot id: A0A8P0T3C7
names: Subcellular Location Annotation
messages: Nucleus

9615:KATNA1
gene id: 9615:KATNA1
uniprot id: A0A8C0N2T4
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

9615:EMP3
gene id: 9615:EMP3
uniprot id: A0A8C0MXM9
uniprot id: A0A8I3MZG6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9615:PDLIM3
gene id: 9615:PDLIM3
uniprot id: A0A8C0NEH4
uniprot id: A0A8C0NLN8
uniprot id: A0A8I3P7P2
uniprot id: A0A8I3PAR1
names: Subcellular Location Annotation
messages: Z line

9615:CLSTN3
gene id: 9615:CLSTN3
uniprot id: A0A8C0NX68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

9615:UBE2K
gene id: 9615:UBE2K
uniprot id: A0A8C0T480
uniprot id: A0A8C0T6H4
uniprot id: A0A8I3ML12
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:CAV2
gene id: 9615:CAV2
uniprot id: O46550
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
messages: Monomer or homodimer. Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).
messages: Most abundant form.
messages: Nucleus
messages: Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).
messages: caveola

9615:GDF3
gene id: 9615:GDF3
uniprot id: A0A8I3Q963
uniprot id: A0A8P0SVG3
names: Similarity
messages: Belongs to the TGF-beta family.

9615:DDX52
gene id: 9615:DDX52
uniprot id: A0A8P0SMF0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

9615:LOC102157323
gene id: 9615:LOC102157323
uniprot id: A0A8C0RN37
uniprot id: A0A8I3NWZ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9615:LOC483905
gene id: 9615:LOC483905
uniprot id: A0A8C0NL57
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9615:NOL10
gene id: 9615:NOL10
uniprot id: A0A8C0QAF5
uniprot id: A0A8I3PZL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

9615:PHACTR4
gene id: 9615:PHACTR4
uniprot id: A0A8C0PYK2
uniprot id: A0A8C0PYY8
uniprot id: A0A8C0PZ31
uniprot id: A0A8I3N3Y6
uniprot id: A0A8I3NAP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

9615:ATP2A2
gene id: 9615:ATP2A2
uniprot id: B6CAN1
uniprot id: O46674
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Ca(2+) and ATP binding cause major rearrangements of the cytoplasmic and transmembrane domains. According to the E1-E2 model, Ca(2+) binding to the cytosolic domain of the pump in the high-affinity E1 conformation is followed by the ATP-dependent phosphorylation of the active site Asp, giving rise to E1P. A conformational change of the phosphoenzyme gives rise to the low-affinity E2P state that exposes the Ca(2+) ions to the lumenal side and promotes Ca(2+) release. Dephosphorylation of the active site Asp mediates the subsequent return to the E1 conformation.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Has different conformational states with differential Ca2+ affinity. The E1 conformational state (active form) shows high Ca(2+) affinity, while the E2 state exhibits low Ca(2+) affinity. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Inhibited by sarcolipin (SLN) and myoregulin (MRLN). The inhibition is blocked by VMP1 (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Stabilizes SERCA2 in its E2 state (By similarity).
messages: Interacts with TRAM2 (via C-terminus).
messages: Interacts with sarcolipin (SLN); the interaction inhibits ATP2A2 Ca(2+) affinity. Interacts with phospholamban (PLN); the interaction inhibits ATP2A2 Ca(2+) affinity (By similarity). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF (By similarity). Interacts with HAX1 (By similarity). Interacts with S100A8 and S100A9 (By similarity). Interacts with SLC35G1 and STIM1. Interacts with TMEM203 (By similarity). Interacts with TMEM64 and PDIA3 (By similarity). Interacts with TMX2 (By similarity). Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with ULK1 (By similarity). Interacts with S100A1 in a Ca(2+)-dependent manner (By similarity). Interacts with TUNAR (By similarity). Interacts with FLVCR2; this interaction occurs in the absence of heme and promotes ATP2A2 proteasomal degradation; this complex is dissociated upon heme binding. Interacts with FNIP1.
messages: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation.
messages: Isoform 1 is expressed in the heart.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity.
messages: PLN and SLN both have a single transmembrane helix; both occupy a similar binding site that is situated between the ATP2A2 transmembrane helices.
messages: Sarcoplasmic reticulum membrane
messages: Serotonylated on Gln residues by TGM2 in response to hypoxia, leading to its inactivation.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes (By similarity). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity).

9615:FAM110D
gene id: 9615:FAM110D
uniprot id: A0A8C0NIS4
names: Similarity
messages: Belongs to the FAM110 family.

9615:FITM1
gene id: 9615:FITM1
uniprot id: A0A8C0N1D3
uniprot id: A0A8I3MXT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

9615:TCTN2
gene id: 9615:TCTN2
uniprot id: A0A8I3RZK2
uniprot id: A0A8P0TSM9
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9615:ACSL1
gene id: 9615:ACSL1
uniprot id: A0A8P0P632
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9615:GMPR
gene id: 9615:GMPR
uniprot id: A0A8C0MVF2
uniprot id: A0A8I3PQD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9615:ETV4
gene id: 9615:ETV4
uniprot id: A0A8C0LYX8
uniprot id: A0A8I3NFG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:MRPL33
gene id: 9615:MRPL33
uniprot id: A0A8C0NB67
uniprot id: A0A8I3NEN8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9615:MLF2
gene id: 9615:MLF2
uniprot id: A0A8C0PBK4
uniprot id: A0A8I3PYK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9615:HOXA10
gene id: 9615:HOXA10
uniprot id: B8PZS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9615:SOX12
gene id: 9615:SOX12
uniprot id: A0A8C0TEB2
names: Subcellular Location Annotation
messages: Nucleus

9615:PHB2
gene id: 9615:PHB2
uniprot id: A0A8C0P996
uniprot id: A0A8I3PW80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9615:NAPG
gene id: 9615:NAPG
uniprot id: A0A8C0MDB0
uniprot id: A0A8I3MT73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9615:SI
gene id: 9615:SI
uniprot id: A0A8C0N6P2
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CASQ2
gene id: 9615:CASQ2
uniprot id: P12637
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:3427023). Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
messages: Detected in heart muscle (at protein level).
messages: Interacts with ASPH (By similarity). Monomer, homodimer and homooligomer. Mostly monomeric in the absence of calcium. Forms higher oligomers in a calcium-dependent manner. Dimers associate to form tetramers, that then form linear homomer chains. Interacts with TRDN.
messages: N-glycosylated.
messages: Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity.
messages: Sarcoplasmic reticulum lumen

9615:IL3
gene id: 9615:IL3
uniprot id: Q9BDX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-3 family.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
messages: Monomer.
messages: Secreted
messages: This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

9615:RNF20
gene id: 9615:RNF20
uniprot id: A0A8C0QN41
uniprot id: A0A8I3N6U1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9615:CDR2L
gene id: 9615:CDR2L
uniprot id: A0A8C0N7J0
uniprot id: A0A8C0N7L9
names: Similarity
messages: Belongs to the CDR2 family.

9615:PSMA3
gene id: 9615:PSMA3
uniprot id: A0A8C0R9W7
uniprot id: A0A8I3P0V3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9615:SGCG
gene id: 9615:SGCG
uniprot id: Q8SQ72
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Disulfide bonds are present.
messages: Interacts with the syntrophin SNTA1. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans. Interacts with FLNC (By similarity).
messages: cytoskeleton
messages: sarcolemma

9615:APRT
gene id: 9615:APRT
uniprot id: A0A8C0S3M2
uniprot id: A0A8I3MH54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

9615:LOC102155800
gene id: 9615:LOC102155800
uniprot id: A0A8C0YV22
uniprot id: A0A8I3PUU5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9615:EML2
gene id: 9615:EML2
uniprot id: A0A8C0M3Q0
uniprot id: A0A8C0RBX1
uniprot id: A0A8I3MMZ7
uniprot id: A0A8I3MVN2
names: Similarity
messages: Belongs to the WD repeat EMAP family.

9615:RTN4IP1
gene id: 9615:RTN4IP1
uniprot id: A0A8C0MWS4
uniprot id: A0A8I3N5Y1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9615:SLC8B1
gene id: 9615:SLC8B1
uniprot id: A0A8I3PJN7
names: Subcellular Location Annotation
messages: Membrane

9615:DRGX
gene id: 9615:DRGX
uniprot id: A0A8C0NTF5
uniprot id: A0A8I3PDM0
names: Subcellular Location Annotation
messages: Nucleus

9615:IAH1
gene id: 9615:IAH1
uniprot id: A0A8C0MD95
uniprot id: A0A8I3Q1T9
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

9615:BORCS7
gene id: 9615:BORCS7
uniprot id: A0A8C0TN89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Lysosome membrane
messages: Membrane

9615:GNRHR
gene id: 9615:GNRHR
uniprot id: Q9MZI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

9615:STAG2
gene id: 9615:STAG2
uniprot id: A0A8C0T340
uniprot id: A0A8I3S9P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9615:ENTR1
gene id: 9615:ENTR1
uniprot id: A0A8I3MXN3
uniprot id: A0A8P0SNS5
names: Similarity
messages: Belongs to the ENTR1 family.

9615:EIF4A3
gene id: 9615:EIF4A3
uniprot id: A0A8C0RW66
uniprot id: A0A8I3NS82
names: Similarity
messages: Belongs to the DEAD box helicase family.

9615:RAB4B
gene id: 9615:RAB4B
uniprot id: P61017
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Serotonylation of Gln-67 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.
messages: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Protein transport. Probably involved in vesicular traffic (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).

9615:TIMELESS
gene id: 9615:TIMELESS
uniprot id: A0A8C0NCH0
uniprot id: A0A8I3N475
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the timeless family.
messages: Nucleus

9615:KMO
gene id: 9615:KMO
uniprot id: A0A8C0NZQ2
uniprot id: E1B2G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
messages: Mitochondrion outer membrane

9615:TMOD4
gene id: 9615:TMOD4
uniprot id: A0A8C0RFA6
uniprot id: A0A8I3PE86
names: Subcellular Location Annotation
messages: cytoskeleton

9615:PHF10
gene id: 9615:PHF10
uniprot id: A0A8C0SAD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

9615:OR10AG65
gene id: 9615:OR10AG65
uniprot id: A0A8C0YXA6
uniprot id: A0A8I3MZY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:PROK1
gene id: 9615:PROK1
uniprot id: A0A8C0SJ77
uniprot id: A0A8I3MRG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9615:HAPLN1
gene id: 9615:HAPLN1
uniprot id: A0A8C0MQF1
uniprot id: A0A8I3PAS0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:ATG13
gene id: 9615:ATG13
uniprot id: A0A8C0PF86
uniprot id: A0A8C0SGP6
uniprot id: A0A8C0YX87
uniprot id: A0A8I3PTC5
uniprot id: A0A8I3PXN2
uniprot id: A0A8I3QDN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9615:BRCA1
gene id: 9615:BRCA1
uniprot id: Q95153
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated, undergoes 'Lys-6'-linked polyubiquitination. 'Lys-6'-linked polyubiquitination does not promote degradation (By similarity).
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1 (By similarity). Interacts with EXD2 (By similarity). Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme (By simila…
messages: Nucleus
messages: Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or ATR. Phosphorylation at Ser-987 by CHEK2 regulates mitotic spindle assembly. Phosphorylation by AURKA regulates centrosomal microtubule nucleation.
messages: The BRCT domains recognize and bind phosphorylated pSXXF motif on proteins. The interaction with the phosphorylated pSXXF motif of ABRAXAS1, recruits BRCA1 at DNA damage sites (By similarity).
messages: The RING-type zinc finger domain interacts with BAP1.

9615:SLC35F4
gene id: 9615:SLC35F4
uniprot id: A0A8P0T1W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9615:SSTR1
gene id: 9615:SSTR1
uniprot id: Q49LX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with SKB1.
messages: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins (By similarity).

9615:PRM2
gene id: 9615:PRM2
uniprot id: A0A8C0RXS1
uniprot id: F7VJL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protamine P2 family.
messages: Interacts with TDRP.
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

9615:AKR1B1
gene id: 9615:AKR1B1
uniprot id: A0A8C0RIR1
uniprot id: A0A8I3P2L6
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9615:MRGPRG
gene id: 9615:MRGPRG
uniprot id: A0A8C0PFZ2
uniprot id: F1PPU1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:PKN1
gene id: 9615:PKN1
uniprot id: A0A8P0TA01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9615:RSAD2
gene id: 9615:RSAD2
uniprot id: A0A8C0Q416
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9615:PRR15
gene id: 9615:PRR15
uniprot id: A0A8C0Q299
uniprot id: A0A8I3NWA0
names: Similarity
messages: Belongs to the PRR15 family.

9615:B3GALNT1
gene id: 9615:B3GALNT1
uniprot id: A0A8I3PVY1
uniprot id: A0A8P0TJH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:MNAT1
gene id: 9615:MNAT1
uniprot id: A0A8C0RSZ2
uniprot id: A0A8I3PKV0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9615:TMEM233
gene id: 9615:TMEM233
uniprot id: A0A8C0T131
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9615:ETFA
gene id: 9615:ETFA
uniprot id: A0A8C0PFF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9615:PPARD
gene id: 9615:PPARD
uniprot id: Q0ZAQ8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Lys-48'-linked polyubiquitinated; leading to proteasomal degradation. Deubiquitinated and stabilized by OTUD3.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Heterodimer with the retinoid X receptor (By similarity). Interacts (via domain NR LBD) with CRY1 and CRY2 in a ligand-dependent manner (By similarity).
messages: Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
messages: Nucleus

9615:TSNAX
gene id: 9615:TSNAX
uniprot id: A0A8C0Q058
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9615:IFNA7
gene id: 9615:IFNA7
uniprot id: A0A8C0TEL2
uniprot id: Q75UL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9615:CCR10
gene id: 9615:CCR10
uniprot id: A0A8C0RZT2
uniprot id: A0A8I3N349
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:TM7SF3
gene id: 9615:TM7SF3
uniprot id: A0A8P0SG41
names: Subcellular Location Annotation
messages: Membrane

9615:OTOP2
gene id: 9615:OTOP2
uniprot id: A0A8P0T5K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9615:TEAD2
gene id: 9615:TEAD2
uniprot id: A0A8C0NKY9
uniprot id: A0A8I3MEV0
names: Subcellular Location Annotation
messages: Nucleus

9615:SLC41A3
gene id: 9615:SLC41A3
uniprot id: A0A8C0SC87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9615:GMPPA
gene id: 9615:GMPPA
uniprot id: A0A8C0NFS9
uniprot id: A0A8I3QXV7
uniprot id: A0A8P0SK23
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9615:RELN
gene id: 9615:RELN
uniprot id: A0A8C0SJM4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the reelin family.
messages: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.
messages: extracellular matrix

9615:PSEN2
gene id: 9615:PSEN2
uniprot id: M1V4F1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

9615:MFAP1
gene id: 9615:MFAP1
uniprot id: A0A8C0Z325
uniprot id: A0A8I3PWP2
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9615:GBA
gene id: 9615:GBA
uniprot id: A0A8C0PPX6
uniprot id: A0A8I3NJQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 30 family.
messages: Lysosome membrane

9615:SVOP
gene id: 9615:SVOP
uniprot id: A0A8C0TI85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9615:ST7L
gene id: 9615:ST7L
uniprot id: A0A8P0THN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9615:RNASEH2A
gene id: 9615:RNASEH2A
uniprot id: A0A8C0P7K1
uniprot id: A0A8I3NML4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

9615:PRR23A
gene id: 9615:PRR23A
uniprot id: A0A8C0NDX2
uniprot id: A0A8I3QC92
names: Similarity
messages: Belongs to the PRR23 family.

9615:EDN2
gene id: 9615:EDN2
uniprot id: P12064
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides.
messages: Secreted

9615:ATP2A1
gene id: 9615:ATP2A1
uniprot id: A0A8C0PSX5
uniprot id: A0A8C0PT52
uniprot id: A0A8I3MN74
uniprot id: A0A8I3MNT3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9615:TOP3B
gene id: 9615:TOP3B
uniprot id: A0A8C0TLE8
uniprot id: A0A8I3PSZ4
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9615:OR6C69G
gene id: 9615:OR6C69G
uniprot id: A0A8C0SYZ0
uniprot id: A0A8I3QA69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:DIO1
gene id: 9615:DIO1
uniprot id: P49894
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iodothyronine deiodinase family.
messages: Endoplasmic reticulum membrane
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.

9615:ATP6V1A
gene id: 9615:ATP6V1A
uniprot id: A0A8C0TRZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Vesicle
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

9615:RBPMS2
gene id: 9615:RBPMS2
uniprot id: A0A8C0NWS3
uniprot id: A0A8I3PFA2
uniprot id: A0A8I3S3S2
uniprot id: A0A8P0PBE7
names: Subcellular Location Annotation
messages: Cytoplasm

9615:LRP1
gene id: 9615:LRP1
uniprot id: A0A8C0MZ75
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:RRAGC
gene id: 9615:RRAGC
uniprot id: A0A8I3QAP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9615:GABRE
gene id: 9615:GABRE
uniprot id: A0A8C0SNK7
uniprot id: A0A8I3S5D0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:NMT1
gene id: 9615:NMT1
uniprot id: A0A8C0MIU6
uniprot id: A0A8I3NDY5
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9615:PRPF19
gene id: 9615:PRPF19
uniprot id: A0A8C0QPA3
uniprot id: A0A8C0RQH3
uniprot id: A0A8I3PCM8
uniprot id: A0A8I3S308
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

9615:CRISP2
gene id: 9615:CRISP2
uniprot id: A0A8C0Q3D4
uniprot id: A0A8I3N019
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SS18L2
gene id: 9615:SS18L2
uniprot id: A0A8C0NIB6
uniprot id: A0A8I3S453
names: Similarity
messages: Belongs to the SS18 family.

9615:ISOC2
gene id: 9615:ISOC2
uniprot id: A0A8C0LZ52
uniprot id: A0A8C0LZ76
uniprot id: A0A8I3MCL0
uniprot id: A0A8I3MX56
names: Similarity
messages: Belongs to the isochorismatase family.

9615:HOXB7
gene id: 9615:HOXB7
uniprot id: A0A8C0RAK9
uniprot id: A0A8I3NDH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:SEPHS1
gene id: 9615:SEPHS1
uniprot id: A0A8C0NIV4
uniprot id: A0A8I3RZH4
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9615:TMEM39A
gene id: 9615:TMEM39A
uniprot id: A0A8C0MN71
uniprot id: A0A8I3NPL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9615:DERL2
gene id: 9615:DERL2
uniprot id: A0A8C0P194
uniprot id: A0A8I3MTN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:EOMES
gene id: 9615:EOMES
uniprot id: A0A8C0T8J2
uniprot id: A0A8I3S4G5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:PPP1R10
gene id: 9615:PPP1R10
uniprot id: A0A8C0SPG3
uniprot id: A0A8I3RV83
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

9615:RAD1
gene id: 9615:RAD1
uniprot id: A0A8C0LY53
uniprot id: A0A8I3MH43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9615:TAS2R42
gene id: 9615:TAS2R42
uniprot id: A0A8C0TSM8
uniprot id: Q2ABC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:JAGN1
gene id: 9615:JAGN1
uniprot id: A0A8C0TN08
uniprot id: A0A8I3N524
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:RXRG
gene id: 9615:RXRG
uniprot id: A0A8C0PBD5
uniprot id: A0A8C0T1Q9
uniprot id: A0A8I3PIS2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9615:TRUB1
gene id: 9615:TRUB1
uniprot id: A0A8C0TM03
uniprot id: A0A8I3SCV0
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9615:HSD17B11
gene id: 9615:HSD17B11
uniprot id: A0A8C0TYF9
uniprot id: A0A8I3NTX0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:SLC6A11
gene id: 9615:SLC6A11
uniprot id: A0A8C0MDK3
uniprot id: A0A8I3RV00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9615:CASKIN2
gene id: 9615:CASKIN2
uniprot id: A0A8C0M9R6
uniprot id: A0A8I3PQL9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9615:NSA2
gene id: 9615:NSA2
uniprot id: A0A8C0QM43
uniprot id: A0A8I3MDE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

9615:PIM1
gene id: 9615:PIM1
uniprot id: A0A8C0N5V7
uniprot id: A0A8I3RY15
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9615:MRPS18A
gene id: 9615:MRPS18A
uniprot id: A0A8C0S1X4
uniprot id: A0A8I3N5L6
names: Subcellular Location Annotation
messages: Mitochondrion

9615:KIF11
gene id: 9615:KIF11
uniprot id: A0A8I3P741
uniprot id: A0A8P0T6A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle pole

9615:OGT
gene id: 9615:OGT
uniprot id: A0A8C0S6N1
uniprot id: A0A8I3P4Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9615:HOPX
gene id: 9615:HOPX
uniprot id: A0A8C0P0L6
uniprot id: A0A8I3NLV8
names: Subcellular Location Annotation
messages: Nucleus

9615:FBP2
gene id: 9615:FBP2
uniprot id: A0A8C0ME46
names: Similarity
messages: Belongs to the FBPase class 1 family.

9615:PLOD1
gene id: 9615:PLOD1
uniprot id: G4V2B6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9615:SLC25A27
gene id: 9615:SLC25A27
uniprot id: A0A8P0T5F7
uniprot id: S6C5C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:LSM7
gene id: 9615:LSM7
uniprot id: A0A8C0MVY2
uniprot id: A0A8I3NI64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9615:GTPBP3
gene id: 9615:GTPBP3
uniprot id: A0A8C0YYM8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

9615:F2
gene id: 9615:F2
uniprot id: A0A8C0PX10
uniprot id: A0A8I3PUT1
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

9615:TBCB
gene id: 9615:TBCB
uniprot id: A0A8C0T3Z6
uniprot id: A0A8I3MF18
names: Similarity
messages: Belongs to the TBCB family.

9615:TPD52L2
gene id: 9615:TPD52L2
uniprot id: A0A8C0PBQ4
uniprot id: A0A8C0PBR2
uniprot id: A0A8C0RSB9
uniprot id: A0A8I3P7S9
uniprot id: A0A8I3S471
names: Similarity
messages: Belongs to the TPD52 family.

9615:SLC6A2
gene id: 9615:SLC6A2
uniprot id: A0A8C0S1P2
uniprot id: B6F0U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9615:SHQ1
gene id: 9615:SHQ1
uniprot id: A0A8I3NGV1
uniprot id: A0A8P0SC06
names: Similarity
messages: Belongs to the SHQ1 family.

9615:LOC100685875
gene id: 9615:LOC100685875
uniprot id: A0A8C0T262
uniprot id: A0A8I3PK03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9615:GPR156
gene id: 9615:GPR156
uniprot id: A0A8C0MXF4
uniprot id: A0A8I3P4R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:SEC22C
gene id: 9615:SEC22C
uniprot id: A0A8C0ND67
uniprot id: A0A8I3S444
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9615:CADM1
gene id: 9615:CADM1
uniprot id: A0A8P0NFC9
names: Similarity
messages: Belongs to the nectin family.

9615:NPY5R
gene id: 9615:NPY5R
uniprot id: O62729
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity).

9615:ATP10B
gene id: 9615:ATP10B
uniprot id: A0A8P0P395
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:NAA60
gene id: 9615:NAA60
uniprot id: A0A8C0RBH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane

9615:MKNK1
gene id: 9615:MKNK1
uniprot id: A0A8C0NXI9
uniprot id: A0A8I3PD30
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:LOC479761
gene id: 9615:LOC479761
uniprot id: A0A8I3NMX2
uniprot id: A0A8P0P697
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9615:CA3
gene id: 9615:CA3
uniprot id: A0A8C0RFT9
uniprot id: A0A8I3P452
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9615:GPR20
gene id: 9615:GPR20
uniprot id: A0A8C0QIX1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:PSMC3IP
gene id: 9615:PSMC3IP
uniprot id: A0A8I3NBI2
uniprot id: A0A8P0NGH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

9615:H2AC21
gene id: 9615:H2AC21
uniprot id: A0A8C0QI60
uniprot id: A0A8I3RWV3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:MMP9
gene id: 9615:MMP9
uniprot id: Q71U09
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with LCN2. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.
messages: extracellular matrix

9615:LOC100855552
gene id: 9615:LOC100855552
uniprot id: P05124
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Cell membrane
messages: Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain. Interacts with SLC12A6 (via C-terminus); the interaction may be required for SLC12A6 potassium-chloride cotransport activity (By similarity).
messages: Mitochondrion
messages: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation. During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work.
messages: The internal MTS-like signal (iMTS-L) mediates targeting to mitochondria thermogenic fat cells.
messages: cytosol

9615:PDCL
gene id: 9615:PDCL
uniprot id: A0A8C0MBY4
uniprot id: A0A8I3NFA9
names: Similarity
messages: Belongs to the phosducin family.

9615:TM9SF1
gene id: 9615:TM9SF1
uniprot id: A0A8C0Q6B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9615:PIK3C2A
gene id: 9615:PIK3C2A
uniprot id: A0A8C0RT86
uniprot id: A0A8I3S670
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9615:AFG3L2
gene id: 9615:AFG3L2
uniprot id: A0A8C0YUB7
uniprot id: A0A8I3MPX0
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9615:PTH
gene id: 9615:PTH
uniprot id: P52212
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).
messages: Secreted

9615:ALDH8A1
gene id: 9615:ALDH8A1
uniprot id: A0A8C0Q252
uniprot id: A0A8I3NAJ1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:LOC106558049
gene id: 9615:LOC106558049
uniprot id: A0A8C0PU31
uniprot id: A0A8I3Q6B9
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9615:PRICKLE3
gene id: 9615:PRICKLE3
uniprot id: A0A8C0SCG0
uniprot id: A0A8I3QDP0
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9615:LOC476047
gene id: 9615:LOC476047
uniprot id: A0A8C0SYF1
uniprot id: A0A8I3MZX2
names: Subcellular Location Annotation
messages: Membrane

9615:CTSK
gene id: 9615:CTSK
uniprot id: Q3ZKN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Secreted
messages: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.

9615:ADRA1A
gene id: 9615:ADRA1A
uniprot id: A0A8C0T458
uniprot id: A0A8I3NK63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9615:KIF5C
gene id: 9615:KIF5C
uniprot id: A0A8C0TFJ0
uniprot id: A0A8I3MWZ5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:DCAF13
gene id: 9615:DCAF13
uniprot id: A0A8C0NZT7
uniprot id: A0A8I3N5L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

9615:MCTS1
gene id: 9615:MCTS1
uniprot id: A0A8C0P1Z0
uniprot id: A0A8C0SW61
uniprot id: A0A8I3PN82
uniprot id: A0A8I3PNX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9615:ZPR1
gene id: 9615:ZPR1
uniprot id: A0A8P0SI18
names: Similarity
messages: Belongs to the ZPR1 family.

9615:AKAP8
gene id: 9615:AKAP8
uniprot id: Q5VK71
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions. Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity).
messages: Belongs to the AKAP95 family.
messages: Binds to dimeric RII-alpha regulatory subunit of PKA during mitosis. Interacts (via C-terminus) with FIGN. Interacts with CCND3 (PubMed:14641107). Interacts with NCAPD2, CCND1, MCM2, RPS6KA1, PDE4A, CASP3, DDX5, CCNE1. Interacts with NFKB1; detetcted in the cytoplasm. Interacts with MYCBP; MYCBP is translocated to the nucleus and the interaction prevents the association of the PKA catalytic subunit leading to suppression of PKA activity. Interacts with DPY30; mediating AKAP8 association with at least the MLL4/WBP7 HMT complex. Interacts with HDAC3; increased during mitosis. Interacts with GJA1; in the nucleus and in the nuclear membrane; the nuclear association increases with progress of cell cycle G1, S and G2 phase and decreases in M phase (By similarity).
messages: Cytoplasm
messages: Nucleus matrix
messages: Phosphorylated on tyrosine residues probably by SRC subfamily protein kinases; multiple phosphorylation is leading to dissociation from nuclear structures implicated in chromatin structural changes.
messages: nucleolus

9615:FOXJ3
gene id: 9615:FOXJ3
uniprot id: A0A8C0PEZ8
uniprot id: A0A8I3NT45
names: Subcellular Location Annotation
messages: Nucleus

9615:DNAJC24
gene id: 9615:DNAJC24
uniprot id: A0A8C0Z3E5
uniprot id: A0A8I3Q3L4
names: Similarity
messages: Belongs to the DPH4 family.

9615:PRKG1
gene id: 9615:PRKG1
uniprot id: A0A8C0TI57
uniprot id: A0A8I3QPW1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9615:F13B
gene id: 9615:F13B
uniprot id: A0A8C0PED8
uniprot id: A0A8I3MGM0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:LOC480601
gene id: 9615:LOC480601
uniprot id: A0A8I3NA82
uniprot id: A0A8P0NRC8
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9615:PGK2
gene id: 9615:PGK2
uniprot id: A0A8C0Q3U2
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9615:LOC489640
gene id: 9615:LOC489640
uniprot id: A0A8C0SI71
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane
messages: sarcolemma

9615:RHBDD1
gene id: 9615:RHBDD1
uniprot id: A0A8C0T6U2
uniprot id: A0A8I3NWS2
names: Subcellular Location Annotation
messages: Membrane

9615:RPS13
gene id: 9615:RPS13
uniprot id: A0A8C0TDT4
uniprot id: A0A8I3Q153
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9615:CPNE5
gene id: 9615:CPNE5
uniprot id: A0A8I3NP56
uniprot id: A0A8I3RXB0
uniprot id: A0A8P0SYB3
uniprot id: A0A8P0T3Q7
names: Similarity
messages: Belongs to the copine family.

9615:SLC6A4
gene id: 9615:SLC6A4
uniprot id: Q33E87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Synapse
messages: focal adhesion
messages: neuron projection

9615:ARPC4
gene id: 9615:ARPC4
uniprot id: A0A8C0TNK7
uniprot id: A0A8I3N156
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

9615:CAV3
gene id: 9615:CAV3
uniprot id: A0A8C0TW67
uniprot id: A0A8I3NGG6
uniprot id: Q3HTT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9615:LOC448801
gene id: 9615:LOC448801
uniprot id: P19236
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Cytoplasm
messages: Inhibited by leupeptin and bis(5-amidino-2-benzimidazolyl)methane (BABIM).
messages: Mononuclear cells within skin, intestine, trachea and lung parenchyma, and polymorphonuclear leukocytes within capillaries and blood.
messages: N-glycosylated.
messages: Oligomer; disulfide-linked.
messages: Trypsin-like serine protease. Has a preference for extended substrates with basic residues at the P1 position; Arg is preferred over Lys. Active towards calcitonin gene-related peptide and gelatin. Not active towards substance P, vasoactive intestinal peptide, type I collagen or azocasein.

9615:SRD5A3
gene id: 9615:SRD5A3
uniprot id: A0A8C0SRL2
uniprot id: A0A8I3NC01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

9615:MIDN
gene id: 9615:MIDN
uniprot id: A0A8C0NRB1
uniprot id: A0A8I3NK90
uniprot id: A0A8P0NKD9
names: Subcellular Location Annotation
messages: Nucleus

9615:HPRT1
gene id: 9615:HPRT1
uniprot id: A0A8C0MLZ6
uniprot id: A0A8I3PNY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9615:VIPR1
gene id: 9615:VIPR1
uniprot id: A0A8C0SRJ5
uniprot id: A0A8I3S164
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9615:NR2C1
gene id: 9615:NR2C1
uniprot id: A0A8C0NG70
uniprot id: A0A8I3PQ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:MIOX
gene id: 9615:MIOX
uniprot id: A0A8C0SNM6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

9615:WAS
gene id: 9615:WAS
uniprot id: A0A8I3PLH5
uniprot id: A0A8P0SJU4
names: Subcellular Location Annotation
messages: Nucleus

9615:NDE1
gene id: 9615:NDE1
uniprot id: A0A8C0PUI9
uniprot id: A0A8I3NA04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9615:MYBL1
gene id: 9615:MYBL1
uniprot id: A0A8C0RIX7
names: Subcellular Location Annotation
messages: Nucleus

9615:CHSY3
gene id: 9615:CHSY3
uniprot id: A0A8I3NHS7
uniprot id: A0A8P0SV25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9615:LCAT
gene id: 9615:LCAT
uniprot id: A0A8C0NJ18
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9615:SLC20A2
gene id: 9615:SLC20A2
uniprot id: A0A8C0Q231
uniprot id: A0A8C0Q3V5
uniprot id: A0A8I3N1I1
uniprot id: A0A8I3N1J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

9615:IYD
gene id: 9615:IYD
uniprot id: A0A8C0N5K4
uniprot id: A0A8I3P5E5
names: Subcellular Location Annotation
messages: Cell membrane

9615:SLC5A12
gene id: 9615:SLC5A12
uniprot id: A0A8C0QHE4
uniprot id: A0A8I3PSW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9615:COQ4
gene id: 9615:COQ4
uniprot id: A0A8I3Q2J5
uniprot id: A0A8P0SW44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

9615:UBR2
gene id: 9615:UBR2
uniprot id: A0A8C0Q8P2
uniprot id: A0A8C0Q935
uniprot id: A0A8I3MZJ1
uniprot id: A0A8I3RSY5
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9615:LMF1
gene id: 9615:LMF1
uniprot id: A0A8C0NE39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Membrane

9615:PRKAR2B
gene id: 9615:PRKAR2B
uniprot id: A0A8C0YXX8
uniprot id: A0A8I3S5X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9615:BHMT
gene id: 9615:BHMT
uniprot id: A0A8C0NUX3
uniprot id: A0A8C0QDD7
uniprot id: A0A8I3MUM0
uniprot id: A0A8I3RTW5
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9615:ATP5IF1
gene id: 9615:ATP5IF1
uniprot id: A0A8C0MWR0
uniprot id: A0A8I3NGS0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9615:TBX19
gene id: 9615:TBX19
uniprot id: Q5XNS0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters (By similarity).

9615:TNFRSF1A
gene id: 9615:TNFRSF1A
uniprot id: A0A8C0TE64
uniprot id: A0A8P0PBA6
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:EHHADH
gene id: 9615:EHHADH
uniprot id: A0A8C0Z6V0
uniprot id: A0A8I3SCF0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9615:DDX28
gene id: 9615:DDX28
uniprot id: A0A8C0SE54
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9615:ROGDI
gene id: 9615:ROGDI
uniprot id: A0A8C0M833
uniprot id: A0A8I3S3B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rogdi family.
messages: Presynapse
messages: Vesicle
messages: synaptic vesicle

9615:LACC1
gene id: 9615:LACC1
uniprot id: A0A8I3NDD4
uniprot id: A0A8P0T3C2
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

9615:IL36G
gene id: 9615:IL36G
uniprot id: A0A8I3N8L5
uniprot id: A0A8P0SW98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

9615:PTP4A3
gene id: 9615:PTP4A3
uniprot id: A0A8C0S0Z6
uniprot id: A0A8I3RXG1
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9615:GALE
gene id: 9615:GALE
uniprot id: A0A8C0LY40
uniprot id: A0A8I3P3X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9615:DTD2
gene id: 9615:DTD2
uniprot id: A0A8C0YXX0
uniprot id: A0A8I3RWR4
names: Similarity
messages: Belongs to the DTD family.

9615:FKBP4
gene id: 9615:FKBP4
uniprot id: A0A8C0PH91
uniprot id: E2QWF5
names: Subcellular Location Annotation
messages: Mitochondrion
messages: cytoskeleton
messages: cytosol

9615:ANXA2
gene id: 9615:ANXA2
uniprot id: Q6TEQ7
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
messages: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with ATP1B1 (By similarity). Interacts with DYSF (By similarity). Interacts with COCH. Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR. Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1 (By similarity). Interacts with APPL2 and APPL1; targets APPL2 to endosomes and acting in parallel to RAB5A (By similarity). Interacts with S100A4 (By similarity). May interact with UBAP2 (By similarity).
messages: ISGylated.
messages: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
messages: basement membrane

9615:RAB5IF
gene id: 9615:RAB5IF
uniprot id: A0A8C0PF04
uniprot id: A0A8C0PJU4
uniprot id: A0A8I3Q8J5
uniprot id: A0A8I3S9V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the GET- and EMC-like (GEL) complex, composed of RAB5IF/OPTI and TMCO1 (PubMed:36261528). The GEL complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47) (PubMed:36261528). The MPT complex associates with the SEC61 complex (PubMed:36261528). Interacts with NDUFS3, NDUFA4, NDUFV1, NDUFA9 and NDUFS8 of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (By similarity). Interacts with UQCRC2 of the ubiquinol-cytochrome c reductase complex (Complex III) (By similarity). Interacts with COX5A and COX7C of the cytochrome c oxidase complex (Complex IV) (By similarity).
messages: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261528). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261528). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (PubMed:36261528). In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes (By similarity).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion inner membrane

9615:CTPS2
gene id: 9615:CTPS2
uniprot id: A0A8C0SM95
uniprot id: A0A8I3QAX6
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9615:STK40
gene id: 9615:STK40
uniprot id: A0A8C0QE80
uniprot id: A0A8C0QG97
uniprot id: A0A8I3Q7U1
uniprot id: A0A8P0S939
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9615:UMPS
gene id: 9615:UMPS
uniprot id: A0A8C0Z612
uniprot id: A0A8I3Q010
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9615:UQCRH
gene id: 9615:UQCRH
uniprot id: A0A8C0NXF6
uniprot id: A0A8I3PBP0
uniprot id: A0A8P0N711
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9615:LEP
gene id: 9615:LEP
uniprot id: O02720
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP…
messages: Secreted

9615:UBAP2
gene id: 9615:UBAP2
uniprot id: A0A8I3PJM6
names: Subcellular Location Annotation
messages: Cytoplasm

9615:BCL2A1
gene id: 9615:BCL2A1
uniprot id: A0A8C0MTY3
names: Similarity
messages: Belongs to the Bcl-2 family.

9615:RAG2
gene id: 9615:RAG2
uniprot id: A0A8C0RCC2
uniprot id: A0A8I3P8Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9615:DNM2
gene id: 9615:DNM2
uniprot id: A0A8C0P214
uniprot id: A0A8C0SYL7
uniprot id: A0A8C0SZZ4
uniprot id: A0A8C0T2P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Cytoplasm

9615:AQP9
gene id: 9615:AQP9
uniprot id: A0A8C0NBN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9615:OR7D4
gene id: 9615:OR7D4
uniprot id: A0A8P0ST27
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:STRIP2
gene id: 9615:STRIP2
uniprot id: A0A8C0YTB4
uniprot id: E2RJF2
names: Similarity
messages: Belongs to the STRIP family.

9615:ADCY4
gene id: 9615:ADCY4
uniprot id: A0A8C0N4S7
uniprot id: A0A8I3RTR3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9615:DOCK2
gene id: 9615:DOCK2
uniprot id: A0A8C0LWD4
uniprot id: A0A8I3MQC8
names: Similarity
messages: Belongs to the DOCK family.

9615:F9
gene id: 9615:F9
uniprot id: P19540
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by factor XIa, which excises the activation peptide. The propeptide can also be removed by snake venom protease.
messages: Belongs to the peptidase S1 family.
messages: Calcium binds to the gamma-carboxyglutamic acid (Gla) residues in the Gla domain. Calcium can also bind, with stronger affinity, to another site beyond the Gla domain. Under physiological ion concentrations, Ca(2+) is displaced by Mg(2+) from some of the gammaglutamate residues in the N-terminal Gla domain. This leads to a subtle conformation change that may affect the interaction with its binding protein.
messages: Defects in F9 are the cause of hemophilia B (HEMB).
messages: Detected in the liver.
messages: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
messages: Heterodimer of a light chain and a heavy chain; disulfide-linked. Interacts with SERPINC1.
messages: Predominantly O-glucosylated at Ser-92 by POGLUT1 in vitro.
messages: Secreted
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

9615:GHR
gene id: 9615:GHR
uniprot id: Q9TU69
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Cell membrane
messages: Expressed in normal and tumorous mammary tissues, being localized in epithelial and myoepithelial/spindle cell components and in the activated fibroblasts of desmoplastic tumor stroma. Isoform 1, isoform 2 and isoform 3 are found in both normal and tumorous mammary tissues, isoform 1 being the predominant isoform. Isoform 1, isoform 3, isoform 4 and isoform 5 are expressed in the CMT-U335 cell line.
messages: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.
messages: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.
messages: On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).
messages: Produced by exon 7 skipping resulting in a frameshift and introduction of a stopcodon at position 619.
messages: Produced by exon 8 skipping resulting in a frameshift and introduction of a stopcodon at position 12 of exon 9.
messages: Produced by the usage of alternative splice donor site resulting in the elimination of a part of exon 7 and the entire exon 8.
messages: Produced by the usage of alternative splice donor/acceptor sites resulting in the elimination of the greater part of exon 6 and the beginning of exon 7.
messages: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity).
messages: Secreted
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
messages: The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.

9615:XPA
gene id: 9615:XPA
uniprot id: A0A8C0MAC1
uniprot id: A0A8I3NWC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9615:ARHGEF11
gene id: 9615:ARHGEF11
uniprot id: A0A8I3NUB9
uniprot id: A0A8P0NHW2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9615:SLC13A3
gene id: 9615:SLC13A3
uniprot id: A0A8I3P9M2
uniprot id: A0A8P0SFH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9615:SCN3B
gene id: 9615:SCN3B
uniprot id: A0A8C0LRA9
uniprot id: A0A8C0S6W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9615:LYPLAL1
gene id: 9615:LYPLAL1
uniprot id: A0A8C0P625
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9615:CLEC12B
gene id: 9615:CLEC12B
uniprot id: A0A8I3SAU5
uniprot id: A0A8P0SI29
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:ELF1
gene id: 9615:ELF1
uniprot id: A0A8C0NJW4
uniprot id: A0A8I3NQS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:FARSB
gene id: 9615:FARSB
uniprot id: A0A8C0YVT0
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

9615:HNRNPF
gene id: 9615:HNRNPF
uniprot id: A0A8C0NZN5
uniprot id: A0A8I3PTS4
names: Subcellular Location Annotation
messages: nucleoplasm

9615:RPS16
gene id: 9615:RPS16
uniprot id: A0A8C0LWX1
uniprot id: A0A8I3N9D0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9615:NR2F6
gene id: 9615:NR2F6
uniprot id: A0A8C0YZC3
uniprot id: A0A8I3QQ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:MED30
gene id: 9615:MED30
uniprot id: A0A8C0M796
uniprot id: A0A8I3NTS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9615:TMEM184B
gene id: 9615:TMEM184B
uniprot id: A0A8C0QHH0
uniprot id: A0A8I3PRV6
uniprot id: A0A8P0N4L0
names: Subcellular Location Annotation
messages: Membrane

9615:BCL7B
gene id: 9615:BCL7B
uniprot id: A0A8C0NCS7
uniprot id: A0A8I3MRA7
names: Similarity
messages: Belongs to the BCL7 family.

9615:TFEB
gene id: 9615:TFEB
uniprot id: A0A8C0MCF3
uniprot id: A0A8I3NYB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9615:TK1
gene id: 9615:TK1
uniprot id: A0A8C0NFL6
uniprot id: A0A8I3S154
names: Similarity
messages: Belongs to the thymidine kinase family.

9615:OR9K2C
gene id: 9615:OR9K2C
uniprot id: A0A8I3NS35
uniprot id: A0A8P0SZZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:MYH11
gene id: 9615:MYH11
uniprot id: A0A8C0NKX8
uniprot id: A0A8C0NTR6
uniprot id: A0A8C0PT46
uniprot id: A0A8I3N4Q0
uniprot id: A0A8I3N9H0
uniprot id: A0A8I3RUP6
uniprot id: A0A8P0SMB1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9615:GLI1
gene id: 9615:GLI1
uniprot id: A0A8C0MKR6
uniprot id: A0A8I3NLD9
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9615:CHAC2
gene id: 9615:CHAC2
uniprot id: A0A8C0PJI0
uniprot id: A0A8I3N3M8
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9615:SEZ6L
gene id: 9615:SEZ6L
uniprot id: A0A8P0NDN1
uniprot id: A0A8P0PE68
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:LOC482987
gene id: 9615:LOC482987
uniprot id: A0A8C0NJI1
uniprot id: A0A8I3PB58
names: Subcellular Location Annotation
messages: Membrane

9615:FAM83E
gene id: 9615:FAM83E
uniprot id: A0A8C0Q551
uniprot id: A0A8I3MN62
names: Similarity
messages: Belongs to the FAM83 family.

9615:ERH
gene id: 9615:ERH
uniprot id: A0A8C0RKE5
uniprot id: A0A8I3RRU1
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9615:CAMTA1
gene id: 9615:CAMTA1
uniprot id: A0A8C0RFB0
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

9615:NDUFA2
gene id: 9615:NDUFA2
uniprot id: A0A8C0PZN0
uniprot id: A0A8I3MRD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:CDC73
gene id: 9615:CDC73
uniprot id: A0A8C0S807
uniprot id: A2SXS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

9615:ZDHHC16
gene id: 9615:ZDHHC16
uniprot id: A0A8C0P650
uniprot id: A0A8C0PAF9
uniprot id: A0A8I3QJD8
uniprot id: A0A8I3QSH1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:GTPBP10
gene id: 9615:GTPBP10
uniprot id: A0A8I3RWN0
uniprot id: A0A8P0N4Z4
uniprot id: A0A8P0TG95
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9615:GALC
gene id: 9615:GALC
uniprot id: P54804
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 59 family.
messages: Defects in GALC are the cause of globoid cell leukodystrophy (GLD). This deficiency results in the insufficient catabolism of several galactolipids that are important in the production of normal myelin.
messages: Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine (PubMed:8661004). Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity).
messages: Lysosome

9615:TUBB4A
gene id: 9615:TUBB4A
uniprot id: A0A8C0NY69
uniprot id: A0A8I3NFI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:PSD3
gene id: 9615:PSD3
uniprot id: A0A8P0P4X3
names: Subcellular Location Annotation
messages: Membrane
messages: ruffle membrane

9615:ADGRG1
gene id: 9615:ADGRG1
uniprot id: A0A8I3MPQ2
uniprot id: A0A8P0TI33
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

9615:BCAT2
gene id: 9615:BCAT2
uniprot id: A0A8C0RJF8
uniprot id: A0A8I3MBI0
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9615:THADA
gene id: 9615:THADA
uniprot id: A8C750
names: Function
names: Similarity
messages: Belongs to the THADA family.
messages: Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.

9615:COPE
gene id: 9615:COPE
uniprot id: A0A8C0N9X2
uniprot id: A0A8I3NYM1
uniprot id: A0A8I3NZ27
uniprot id: A0A8P0SJC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9615:IRGQ
gene id: 9615:IRGQ
uniprot id: A0A8C0SIP4
uniprot id: A0A8I3M9Y7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9615:NRTN
gene id: 9615:NRTN
uniprot id: A0A8C0TVN1
uniprot id: E2R534
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9615:UBE2M
gene id: 9615:UBE2M
uniprot id: A0A8C0RW57
uniprot id: A0A8I3MA68
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:NFIA
gene id: 9615:NFIA
uniprot id: A0A8P0T5S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9615:FAM241B
gene id: 9615:FAM241B
uniprot id: A0A8C0Q688
uniprot id: A0A8I3MIW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9615:RAB5A
gene id: 9615:RAB5A
uniprot id: P18066
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Early endosome membrane
messages: Endosome membrane
messages: Interacts with GDI1; this promotes dissociation from membranes; phosphorylation at Ser-84 disrupts this interaction (By similarity). Interacts with GDI2; phosphorylation at Ser-84 disrupts the interaction (By similarity). Binds EEA1. Interacts with ALS2CL, SUN2, ZFYVE20 and RUFY1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB (By similarity). Interacts with RABEP1 and RINL (PubMed:8521472, PubMed:21419809). Interacts with OCRL and INPP5F. May be a component of a complex composed of RAB5A, DYN2 and PIK3C3 (By similarity). Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4) (PubMed:20048159). Interacts with CLN5 (By similarity). Interacts with APPL2 (By similarity). Interacts with F8A1/F8A2/F8A3 (By similarity). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity). Interacts with ATP9A (By similarity).
messages: Melanosome
messages: Membrane
messages: Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:8521472). RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
messages: cytosol
messages: phagosome membrane
messages: ruffle

9615:CFHR5
gene id: 9615:CFHR5
uniprot id: A0A8C0SK64
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CSGALNACT2
gene id: 9615:CSGALNACT2
uniprot id: A0A8C0TUH7
uniprot id: A0A8C0TYX2
uniprot id: A0A8I3Q1Q4
uniprot id: A0A8I3Q2I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9615:WASF1
gene id: 9615:WASF1
uniprot id: A0A8C0QR97
uniprot id: A0A8I3NNZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9615:MRE11
gene id: 9615:MRE11
uniprot id: A0A8C0SYU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

9615:IER2
gene id: 9615:IER2
uniprot id: A0A8C0TH38
uniprot id: A0A8I3S7L7
names: Similarity
messages: Belongs to the IER family.

9615:CHUK
gene id: 9615:CHUK
uniprot id: A0A8C0Z216
uniprot id: A0A8I3P499
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:LOC474938
gene id: 9615:LOC474938
uniprot id: A0A059V712
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9615:ARL8B
gene id: 9615:ARL8B
uniprot id: A0A8C0MTI6
uniprot id: A0A8I3N7D8
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: spindle

9615:IL10
gene id: 9615:IL10
uniprot id: P48411
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-10 family.
messages: Homodimer. Interacts with IL10RA and IL10RB.
messages: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
messages: Secreted

9615:RPL17
gene id: 9615:RPL17
uniprot id: A0A8C0YXW1
uniprot id: A0A8I3NZS5
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9615:GRK2
gene id: 9615:GRK2
uniprot id: A0A8C0SDN0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9615:XRCC3
gene id: 9615:XRCC3
uniprot id: A0A8I3PAY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

9615:ATP2B4
gene id: 9615:ATP2B4
uniprot id: A0A8C0NC13
uniprot id: A0A8C0NGP8
uniprot id: A0A8C0SG94
uniprot id: A0A8I3PEN3
uniprot id: A0A8I3S160
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:METAP2
gene id: 9615:METAP2
uniprot id: A0A8C0N942
uniprot id: A0A8C0QH43
uniprot id: A0A8I3PF51
uniprot id: A0A8I3S7G5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9615:RAMAC
gene id: 9615:RAMAC
uniprot id: A0A8C0LZN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAM family.
messages: Nucleus

9615:STARD5
gene id: 9615:STARD5
uniprot id: A0A8C0PP66
uniprot id: A0A8I3MLS9
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9615:SPG21
gene id: 9615:SPG21
uniprot id: A0A8C0NRQ0
uniprot id: A0A8I3PLL7
names: Function
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9615:LOC610578
gene id: 9615:LOC610578
uniprot id: A0A8P0NQ22
uniprot id: A0A8P0S8N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9615:PIGB
gene id: 9615:PIGB
uniprot id: A0A8C0TYL0
uniprot id: A0A8I3QPJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:ETV2
gene id: 9615:ETV2
uniprot id: A0A8P0N9F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:METTL6
gene id: 9615:METTL6
uniprot id: A0A8I3PVU1
uniprot id: A0A8I3PZN4
uniprot id: A0A8P0PPW3
uniprot id: A0A8P0SBG4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9615:TPMT
gene id: 9615:TPMT
uniprot id: Q8HX86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

9615:AGK
gene id: 9615:AGK
uniprot id: A0A8C0MKV6
uniprot id: A0A8I3Q635
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9615:CPLX3
gene id: 9615:CPLX3
uniprot id: A0A8C0MYD4
uniprot id: A0A8I3P5K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9615:GNPNAT1
gene id: 9615:GNPNAT1
uniprot id: A0A8C0RUL0
uniprot id: A0A8I3MSH5
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9615:LOC608550
gene id: 9615:LOC608550
uniprot id: A0A8C0Q3M6
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9615:FAM72A
gene id: 9615:FAM72A
uniprot id: A0A8C0T7S9
uniprot id: A0A8I3PWG4
names: Similarity
messages: Belongs to the FAM72 family.

9615:TMEM86B
gene id: 9615:TMEM86B
uniprot id: A0A8C0S0N7
uniprot id: A0A8I3MIS6
uniprot id: A0A8P0N5M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9615:PHTF1
gene id: 9615:PHTF1
uniprot id: A0A8C0QB33
uniprot id: A0A8C0QH90
uniprot id: A0A8I3PAC6
uniprot id: A0A8I3PG78
names: Subcellular Location Annotation
messages: Membrane

9615:TMEM225B
gene id: 9615:TMEM225B
uniprot id: A0A8I3MNF8
uniprot id: A0A8I3MP24
names: Subcellular Location Annotation
messages: Membrane

9615:FMO1
gene id: 9615:FMO1
uniprot id: Q95LA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMO family.
messages: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (By similarity). Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (By similarity). In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (By similarity).
messages: Endoplasmic reticulum membrane
messages: Liver.

9615:PAQR8
gene id: 9615:PAQR8
uniprot id: A0A8C0NWE3
uniprot id: A0A8I3NA56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9615:RPS7
gene id: 9615:RPS7
uniprot id: A0A8C0Q0X5
uniprot id: A0A8I3PNN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: centrosome

9615:MMP14
gene id: 9615:MMP14
uniprot id: A0A8C0NSG8
uniprot id: A0A8I3MND9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Cytoplasm
messages: Melanosome

9615:NFS1
gene id: 9615:NFS1
uniprot id: A0A8C0S3Q0
uniprot id: A0A8I3PIA7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9615:SSH2
gene id: 9615:SSH2
uniprot id: A0A8C0PSV4
uniprot id: A0A8I3RWU3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9615:CHRM3
gene id: 9615:CHRM3
uniprot id: A0A8C0RUM6
uniprot id: A0A8I3N190
uniprot id: A0A8P0SEV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9615:ING4
gene id: 9615:ING4
uniprot id: A0A8C0PKT4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9615:EHD3
gene id: 9615:EHD3
uniprot id: A0A8C0SE95
uniprot id: A0A8I3NXA3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9615:PRORP
gene id: 9615:PRORP
uniprot id: A0A8C0MGJ5
uniprot id: A0A8I3MEK7
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9615:CCNG1
gene id: 9615:CCNG1
uniprot id: A0A8C0NI67
uniprot id: A0A8I3RQW5
names: Similarity
messages: Belongs to the cyclin family.

9615:OR56B2
gene id: 9615:OR56B2
uniprot id: A0A8C0MUR3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:POLR1A
gene id: 9615:POLR1A
uniprot id: A0A8C0Z124
uniprot id: A0A8I3NGT8
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9615:TEC
gene id: 9615:TEC
uniprot id: A0A8C0S3M6
uniprot id: A0A8I3NBM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:MID1
gene id: 9615:MID1
uniprot id: A0A8C0MNF0
uniprot id: A0A8I3S5W2
names: Subcellular Location Annotation
messages: cytoskeleton

9615:UPK1B
gene id: 9615:UPK1B
uniprot id: A0A8C0MND4
names: Subcellular Location Annotation
messages: Membrane

9615:LYZF2
gene id: 9615:LYZF2
uniprot id: A0A077S9R2
uniprot id: A0A8C0P8H7
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9615:PPIL1
gene id: 9615:PPIL1
uniprot id: A0A8C0N2E1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9615:CCL13
gene id: 9615:CCL13
uniprot id: Q68Y88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity).
messages: Secreted

9615:CCR1
gene id: 9615:CCR1
uniprot id: A0A8C0PWA0
uniprot id: A0A8I3RZ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9615:CNNM2
gene id: 9615:CNNM2
uniprot id: A0A8C0PBG9
uniprot id: A0A8C0TQH4
uniprot id: A0A8I3PSU6
uniprot id: A0A8I3PYS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9615:POU3F4
gene id: 9615:POU3F4
uniprot id: A0A8C0QIH8
uniprot id: A0A8I3PBR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9615:USP4
gene id: 9615:USP4
uniprot id: A0A8C0NH91
uniprot id: A0A8C0NPQ3
uniprot id: A0A8I3PV71
uniprot id: A0A8I3PWL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9615:THTPA
gene id: 9615:THTPA
uniprot id: A0A8I3MTM4
uniprot id: A0A8P0PLT9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9615:STT3B
gene id: 9615:STT3B
uniprot id: E2RG47
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STT3 family.
messages: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation (PubMed:12887896).
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.
messages: Despite low primary sequence conservation between eukaryotic catalytic subunits and bacterial and archaeal single subunit OSTs (ssOST), structural comparison revealed several common motifs at spatially equivalent positions, like the DXD motif 1 on the external loop 1 and the DXD motif 2 on the external loop 2 involved in binding of the metal ion cofactor and the carboxamide group of the acceptor asparagine, the conserved Glu residue of the TIXE/SVSE motif on the external loop 5 involved in catalysis, as well as the WWDYG and the DK/MI motifs in the globular domain that define the binding pocket for the +2 Ser/Thr of the acceptor sequon. In bacterial ssOSTs, an Arg residue was found to interact with a negatively charged side chain at the -2 position of the sequon. This Arg is conserved in bacterial enzymes and correlates with an extended sequon requirement (Asp-X-Asn-X-Ser/Thr) for bacterial N-glycosylation.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane

9615:IFNAR1
gene id: 9615:IFNAR1
uniprot id: A0A8C0MNF2
uniprot id: F1PRZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9615:MAPT
gene id: 9615:MAPT
uniprot id: A0A8P0SIH1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: axon
messages: cytoskeleton
messages: cytosol
messages: dendrite

9615:MRPS9
gene id: 9615:MRPS9
uniprot id: A0A8I3NF66
uniprot id: A0A8P0N582
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9615:SULT4A1
gene id: 9615:SULT4A1
uniprot id: A0A8C0SDW5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:LOC100856533
gene id: 9615:LOC100856533
uniprot id: A0A8C0PG31
uniprot id: A0A8I3PRI6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9615:MCPH1
gene id: 9615:MCPH1
uniprot id: Q6PYB7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
messages: centrosome

9615:LOC485601
gene id: 9615:LOC485601
uniprot id: A0A8C0T5P6
uniprot id: A0A8I3NW57
names: Similarity
messages: Belongs to the peptidase C14A family.

9615:MYO18A
gene id: 9615:MYO18A
uniprot id: A0A8C0MVZ3
uniprot id: A0A8C0TM38
uniprot id: A0A8I3NEU8
uniprot id: A0A8I3NRI2
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:KIFC3
gene id: 9615:KIFC3
uniprot id: A0A8C0M2K5
uniprot id: A0A8I3MJU7
uniprot id: A0A8I3MNR5
uniprot id: A0A8P0NAS8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:ING2
gene id: 9615:ING2
uniprot id: A0A8C0NI99
uniprot id: A0A8I3NQF3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9615:CNDP1
gene id: 9615:CNDP1
uniprot id: A0A8C0PKI8
uniprot id: A0A8I3MIJ8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9615:TOMM40
gene id: 9615:TOMM40
uniprot id: A0A8C0RAS4
uniprot id: A0A8I3N267
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:DLAT
gene id: 9615:DLAT
uniprot id: A0A8C0NAN7
uniprot id: A0A8I3MZS6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9615:H2AZ2
gene id: 9615:H2AZ2
uniprot id: A0A8C0MLN7
uniprot id: A0A8C0TN40
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:CYB561
gene id: 9615:CYB561
uniprot id: A0A8I3P5S0
uniprot id: A0A8P0SI33
names: Subcellular Location Annotation
messages: Membrane

9615:SLC17A9
gene id: 9615:SLC17A9
uniprot id: A0A8C0TKN2
uniprot id: A0A8I3PEG6
names: Subcellular Location Annotation
messages: Membrane

9615:ANXA13
gene id: 9615:ANXA13
uniprot id: Q29471
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Apical cell membrane
messages: Belongs to the annexin family.
messages: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium (By similarity). May play a role in vesicular traffic to the apical plasma membrane (Probable).
messages: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Detected in intestine, and at much lower levels also in kidney (at protein level).
messages: Monomer and homodimer.

9615:EFNA1
gene id: 9615:EFNA1
uniprot id: A0A8P0SLB8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:GAS8
gene id: 9615:GAS8
uniprot id: A0A8C0TF27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum
messages: flagellum axoneme

9615:CYP51A1
gene id: 9615:CYP51A1
uniprot id: A0A8P0N517
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:MED8
gene id: 9615:MED8
uniprot id: A0A8C0MW17
uniprot id: A0A8I3PEC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:IMMP2L
gene id: 9615:IMMP2L
uniprot id: A0A8C0SMB1
uniprot id: A0A8I3QWH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

9615:PLA2G3
gene id: 9615:PLA2G3
uniprot id: A0A8C0TLK4
uniprot id: A0A8I3PFI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9615:TM2D2
gene id: 9615:TM2D2
uniprot id: A0A8C0QR28
uniprot id: A0A8I3N8V7
names: Subcellular Location Annotation
messages: Membrane

9615:TIMM17B
gene id: 9615:TIMM17B
uniprot id: A0A8C0MNG2
uniprot id: A0A8I3QW29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

9615:UBE2S
gene id: 9615:UBE2S
uniprot id: A0A8C0M095
uniprot id: A0A8I3MFS7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:ARHGAP32
gene id: 9615:ARHGAP32
uniprot id: A0A8C0YYH8
uniprot id: A0A8P0NPV5
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

9615:KCNJ4
gene id: 9615:KCNJ4
uniprot id: A0A8C0NF94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9615:CLGN
gene id: 9615:CLGN
uniprot id: A0A8P0P723
names: Similarity
messages: Belongs to the calreticulin family.

9615:APOOL
gene id: 9615:APOOL
uniprot id: A0A8C0NT18
uniprot id: A0A8C0S5J6
uniprot id: A0A8I3PJ66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9615:LOC483462
gene id: 9615:LOC483462
uniprot id: A0A8C0RMK9
uniprot id: A0A8I3PCA4
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9615:FIGNL1
gene id: 9615:FIGNL1
uniprot id: A0A8C0SRT2
uniprot id: A0A8I3N9F1
names: Similarity
messages: Belongs to the AAA ATPase family.

9615:ATP6V0B
gene id: 9615:ATP6V0B
uniprot id: A0A8C0NJP4
uniprot id: A0A8I3SB94
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9615:MTMR10
gene id: 9615:MTMR10
uniprot id: A0A8C0T5R0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9615:TM9SF4
gene id: 9615:TM9SF4
uniprot id: A0A8C0TMC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9615:PPARG
gene id: 9615:PPARG
uniprot id: Q4U3Q4
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Interacts with FOXO1 (acetylated form) (By similarity). Heterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts with ASXL1, ASXL2, DNTTIP2, FAM120B, MAP2K1/MEK1, NR0B2, PDPK1, PRDM16, PRMT2 and TGFB1I1. Interacts (when activated by agonist) with PPP5C. Interacts with HELZ2 and THRAP3; the interaction stimulates the transcriptional activity of PPARG. Interacts with PER2, the interaction is ligand dependent and blocks PPARG recruitment to target promoters. Interacts with NOCT. Interacts with ACTN4. Interacts (when in the liganded conformation) with GPS2 (By similarity). Interacts with CRY1 and CRY2 in a ligand-dependent manner (By similarity). In the absence of hormonal ligand, interacts with TACC1 (By similarity).
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels.
messages: Nucleus
messages: PDPK1 activates its transcriptional activity independently of its kinase activity.
messages: Phosphorylated at basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation induces adipogenic activity (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9615:C1RL
gene id: 9615:C1RL
uniprot id: A0A8P0NSA4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PRR15L
gene id: 9615:PRR15L
uniprot id: A0A8P0NI82
names: Similarity
messages: Belongs to the PRR15 family.

9615:ACVRL1
gene id: 9615:ACVRL1
uniprot id: A0A7I8AUV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9615:CXXC5
gene id: 9615:CXXC5
uniprot id: A0A8I3MH47
uniprot id: A0A8P0SB78
names: Subcellular Location Annotation
messages: Cytoplasm

9615:H1-10
gene id: 9615:H1-10
uniprot id: A0A8C0TZ50
uniprot id: A0A8I3P7C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9615:PGM2
gene id: 9615:PGM2
uniprot id: A0A8C0PRW0
uniprot id: A0A8I3MSC7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9615:FAM214A
gene id: 9615:FAM214A
uniprot id: A0A8C0TYB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

9615:UNC119
gene id: 9615:UNC119
uniprot id: A0A8C0RJA4
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9615:TMEM138
gene id: 9615:TMEM138
uniprot id: A0A8C0QDF6
uniprot id: A0A8I3NCD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9615:CDKL4
gene id: 9615:CDKL4
uniprot id: A0A8C0TRE9
uniprot id: A0A8I3PF24
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:SPAG7
gene id: 9615:SPAG7
uniprot id: A0A8C0Q3Z0
names: Subcellular Location Annotation
messages: Nucleus

9615:FGF5
gene id: 9615:FGF5
uniprot id: Q20FD0
names: Function
names: Miscellaneous
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).
messages: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
messages: Secreted
messages: Seems to have an antagonistic effect compared to that of the isoform Long.
messages: The polymorphism in position 95 is responsible for hair length variation. The long-haired phenotype is associated with Phe-95 or with the insertion in position 50.

9615:GATA5
gene id: 9615:GATA5
uniprot id: A0A8C0N6R0
uniprot id: A0A8I3RZQ7
names: Subcellular Location Annotation
messages: Nucleus

9615:POLRMT
gene id: 9615:POLRMT
uniprot id: A0A8C0SAC0
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9615:DOCK5
gene id: 9615:DOCK5
uniprot id: A0A8C0Z341
names: Similarity
messages: Belongs to the DOCK family.

9615:PARP16
gene id: 9615:PARP16
uniprot id: A0A8I3PXK7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9615:ATP2A3
gene id: 9615:ATP2A3
uniprot id: A0A8C0RZB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9615:PRDX2
gene id: 9615:PRDX2
uniprot id: A0A8C0Z5S7
uniprot id: A0A8I3NZ15
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9615:PEX3
gene id: 9615:PEX3
uniprot id: A0A8C0PYP3
uniprot id: A0A8I3RWW4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9615:E2F2
gene id: 9615:E2F2
uniprot id: A0A8I3NKC8
uniprot id: A0A8P0SR78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9615:ATRNL1
gene id: 9615:ATRNL1
uniprot id: A0A8P0SGR4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TLN2
gene id: 9615:TLN2
uniprot id: A0A8C0MT17
uniprot id: A0A8I3S166
names: Subcellular Location Annotation
messages: cytoskeleton

9615:CADM2
gene id: 9615:CADM2
uniprot id: A0A8I3PTC6
uniprot id: A0A8I3SA59
uniprot id: A0A8P0NSS6
uniprot id: A0A8P0P6P6
names: Similarity
messages: Belongs to the nectin family.

9615:ABCD4
gene id: 9615:ABCD4
uniprot id: A0A8C0S8X6
names: Subcellular Location Annotation
messages: Membrane

9615:LHFPL6
gene id: 9615:LHFPL6
uniprot id: A0A8C0NSZ9
uniprot id: A0A8I3S4U0
names: Subcellular Location Annotation
messages: Membrane

9615:FAM161A
gene id: 9615:FAM161A
uniprot id: A0A8P0SQ10
names: Similarity
messages: Belongs to the FAM161 family.

9615:LOC100686441
gene id: 9615:LOC100686441
uniprot id: A0A8P0TMX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9615:CKMT2
gene id: 9615:CKMT2
uniprot id: A0A8C0NUI5
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9615:UCMA
gene id: 9615:UCMA
uniprot id: A0A8C0PZL8
uniprot id: A0A8I3P8X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

9615:BRPF1
gene id: 9615:BRPF1
uniprot id: A0A8C0TTT5
uniprot id: A0A8I3NMP5
uniprot id: A0A8P0TAR3
names: Subcellular Location Annotation
messages: Nucleus

9615:CD70
gene id: 9615:CD70
uniprot id: A0A8C0NZL5
uniprot id: A0A8I3NFC1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9615:GNAS
gene id: 9615:GNAS
uniprot id: P63091
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(s) subfamily.
messages: Cell membrane
messages: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.
messages: Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with CRY1; the interaction may block GPCR-mediated regulation of cAMP concentrations. Interacts with ADCY6 and stimulates its adenylyl cyclase activity (By similarity). Interacts with ADCY2 and ADCY5 (By similarity). Stimulates the ADCY5 adenylyl cyclase activity (By similarity). Interaction with SASH1 (By similarity).

9615:FAM83H
gene id: 9615:FAM83H
uniprot id: A0A8P0NSK8
uniprot id: H6VX52
names: Similarity
messages: Belongs to the FAM83 family.

9615:IL19
gene id: 9615:IL19
uniprot id: A0A8C0SLH8
uniprot id: A0A8I3ME35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9615:SH3BP5
gene id: 9615:SH3BP5
uniprot id: A0A8I3PXG6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9615:LPAR5
gene id: 9615:LPAR5
uniprot id: A0A8C0T120
uniprot id: A0A8I3SBJ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:CSF2
gene id: 9615:CSF2
uniprot id: P48749
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).
messages: Secreted

9615:GALR1
gene id: 9615:GALR1
uniprot id: A0A8C0PJJ2
uniprot id: A0A8I3MC04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9615:RCAN1
gene id: 9615:RCAN1
uniprot id: A0A8C0PJW4
uniprot id: A0A8C0PPK3
uniprot id: A0A8I3PN72
uniprot id: A0A8I3Q8C4
names: Similarity
messages: Belongs to the RCAN family.

9615:DVL1
gene id: 9615:DVL1
uniprot id: A0A8C0Q2G1
names: Similarity
messages: Belongs to the DSH family.

9615:CD14
gene id: 9615:CD14
uniprot id: A0A1S7J0A8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane raft
messages: Secreted

9615:UROS
gene id: 9615:UROS
uniprot id: A0A8C0TFR4
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9615:FLNB
gene id: 9615:FLNB
uniprot id: A0A8C0P3R9
uniprot id: A0A8C0PEU4
uniprot id: A0A8C0S7X1
uniprot id: A0A8C0S8F1
uniprot id: A0A8I3PEC3
uniprot id: A0A8I3S4M6
names: Similarity
messages: Belongs to the filamin family.

9615:ITGA10
gene id: 9615:ITGA10
uniprot id: A0A8C0QEX0
uniprot id: A0A8I3RW71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:POLR3G
gene id: 9615:POLR3G
uniprot id: A0A8C0PUJ9
uniprot id: A0A8I3RZE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9615:ITGA6
gene id: 9615:ITGA6
uniprot id: A0A8C0S8I3
uniprot id: A0A8C0S951
uniprot id: A0A8I3QH94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:PMPCB
gene id: 9615:PMPCB
uniprot id: A0A8C0SQP4
uniprot id: A0A8I3NYF1
names: Similarity
messages: Belongs to the peptidase M16 family.

9615:PBX1
gene id: 9615:PBX1
uniprot id: A0A8C0P0Q2
uniprot id: A0A8I3PRG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9615:CHST8
gene id: 9615:CHST8
uniprot id: A0A8C0QDC5
uniprot id: A0A8I3MJR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:MAP1LC3A
gene id: 9615:MAP1LC3A
uniprot id: A0A8C0P1P2
uniprot id: A0A8I3RZ71
names: Similarity
messages: Belongs to the ATG8 family.

9615:LOC476006
gene id: 9615:LOC476006
uniprot id: A0A8C0S6P0
uniprot id: A0A8I3NDR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

9615:AZGP1
gene id: 9615:AZGP1
uniprot id: A0A8C0Z0R3
uniprot id: A0A8I3RR08
names: Similarity
messages: Belongs to the MHC class I family.

9615:SEC13
gene id: 9615:SEC13
uniprot id: A0A8C0RD48
uniprot id: A0A8I3RVL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane

9615:RNF8
gene id: 9615:RNF8
uniprot id: A0A8C0T933
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9615:TLE7
gene id: 9615:TLE7
uniprot id: A0A8C0MT09
uniprot id: A0A8I3N0A9
names: Similarity
messages: Belongs to the WD repeat Groucho/TLE family.

9615:VIPR2
gene id: 9615:VIPR2
uniprot id: A0A8C0PGB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9615:LTBR
gene id: 9615:LTBR
uniprot id: A0A8C0PHW1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:KAT5
gene id: 9615:KAT5
uniprot id: A0A8C0NLP0
uniprot id: A0A8C0RJW0
uniprot id: A0A8C0YZX3
uniprot id: A0A8I3PEI4
uniprot id: A0A8I3S3L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9615:AGBL2
gene id: 9615:AGBL2
uniprot id: A0A8P0NAR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9615:LOC100687749
gene id: 9615:LOC100687749
uniprot id: A0A8C0S4Y9
uniprot id: J9NZS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9615:PRRC1
gene id: 9615:PRRC1
uniprot id: A0A8C0PKX5
uniprot id: A0A8I3NCY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

9615:OR51P1
gene id: 9615:OR51P1
uniprot id: A4GXA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:NETO1
gene id: 9615:NETO1
uniprot id: A0A8C0LYC5
uniprot id: A0A8I3MHI4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CPNE1
gene id: 9615:CPNE1
uniprot id: A0A8P0NAH9
names: Similarity
messages: Belongs to the copine family.

9615:GMPPB
gene id: 9615:GMPPB
uniprot id: A0A8C0SY08
uniprot id: A0A8I3PK79
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9615:TMEM251
gene id: 9615:TMEM251
uniprot id: A0A8I3NR99
uniprot id: A0A8P0NIQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LYSET family.
messages: Membrane

9615:WASHC3
gene id: 9615:WASHC3
uniprot id: A0A8C0N532
uniprot id: A0A8I3N9Z9
names: Similarity
messages: Belongs to the CCDC53 family.

9615:GAD1
gene id: 9615:GAD1
uniprot id: A0PA85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.
messages: Homodimer.

9615:HARS2
gene id: 9615:HARS2
uniprot id: A0A8I3RS66
uniprot id: A0A8P0PCH0
uniprot id: A0A8P0SXL5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9615:ENKUR
gene id: 9615:ENKUR
uniprot id: A0A8C0RKV2
uniprot id: A0A8I3MP67
names: Subcellular Location Annotation
messages: cilium axoneme

9615:CALHM2
gene id: 9615:CALHM2
uniprot id: A0A8C0TMT6
uniprot id: A0A8I3S6F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9615:CYSLTR1
gene id: 9615:CYSLTR1
uniprot id: A0A8C0Z0K5
uniprot id: A0A8I3PED5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:FOXI1
gene id: 9615:FOXI1
uniprot id: A0A8C0R9D4
uniprot id: A0A8I3MFQ1
names: Subcellular Location Annotation
messages: Nucleus

9615:ALDH3B1
gene id: 9615:ALDH3B1
uniprot id: A0A8C0S2P9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:SLC25A35
gene id: 9615:SLC25A35
uniprot id: A0A8C0SEI1
uniprot id: A0A8I3MHQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:FOXI3
gene id: 9615:FOXI3
uniprot id: B5RHS5
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Defects in FOXI3 are the cause of canine ectodermal dysplasia (CED) (PubMed:18787161). CED is an autosomal semi-dominant trait characterized by missing or abnormally shaped teeth in addition to a hair coat that is sparse or absent (PubMed:18787161). Haploinsufficiency of FOXI3 leads to an incomplete development of the lingually positioned cusps in the trigon and talon parts of both upper and lower molars and deciduous fourth premolars, respectively. As a result, the mandibular first molars in the hairless dogs are mesiodistally shorter than those in the coated dogs (PubMed:28710361). Heterozygous mutants are found in Mexican and Peruvian hairless dogs and in Chinese crested dogs (PubMed:18787161). Homozygous mutants die during embryogenesis (PubMed:18787161).
messages: Nucleus
messages: Phosphorylation promotes the transcription factor activity. Dephosphorylation by protein phosphatase 2A (PP2A) reduces its activity.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor required for pharyngeal arch development, and which is involved in hair, ear, jaw and dental development (PubMed:18787161, PubMed:28710361). May act as a pioneer transcription factor during pharyngeal arch development (By similarity). Required for the development of the epithelium of hair and whisker placodes and that of teeth (PubMed:18787161, PubMed:28710361). Required for hair follicle stem cell specification (By similarity). Acts downstream of TBX1 for the formation of the thymus and parathyroid glands from the third pharyngeal pouch (By similarity).

9615:SHMT1
gene id: 9615:SHMT1
uniprot id: A0A8C0RW38
uniprot id: A0A8I3S1J1
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9615:PTPN13
gene id: 9615:PTPN13
uniprot id: A0A8P0NV17
uniprot id: A0A8P0P7B7
uniprot id: A0A8P0T3Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
messages: cytoskeleton

9615:MPG
gene id: 9615:MPG
uniprot id: A0A8C0S9W0
uniprot id: A0A8I3MIB3
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

9615:JPH3
gene id: 9615:JPH3
uniprot id: A0A8C0SG19
uniprot id: A0A8I3MRG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9615:DSG2
gene id: 9615:DSG2
uniprot id: A0A8C0SFV3
uniprot id: A0A8I3RY38
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9615:POLR3C
gene id: 9615:POLR3C
uniprot id: A0A8C0NEB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9615:NFIB
gene id: 9615:NFIB
uniprot id: A0A8C0NAK7
uniprot id: A0A8C0RHQ2
uniprot id: A0A8C0YZN3
uniprot id: A0A8I3NGG1
uniprot id: A0A8I3RW85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9615:LAPTM4B
gene id: 9615:LAPTM4B
uniprot id: A0A8C0NNC7
uniprot id: A0A8I3S7G8
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9615:EIF4A1
gene id: 9615:EIF4A1
uniprot id: A0A8C0NHT7
uniprot id: A0A8I3S757
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9615:ATP2B1
gene id: 9615:ATP2B1
uniprot id: A0A8C0NHL9
uniprot id: A0A8I3P5E8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:ROPN1
gene id: 9615:ROPN1
uniprot id: A0A8C0TQS3
uniprot id: A0A8I3PWA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

9615:SPCS2
gene id: 9615:SPCS2
uniprot id: Q28250
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:3511473). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SEC11A or SEC11C and SPCS1 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
messages: Endoplasmic reticulum membrane

9615:SZRD1
gene id: 9615:SZRD1
uniprot id: A0A8C0Q065
uniprot id: A0A8I3MLT9
names: Similarity
messages: Belongs to the SZRD1 family.

9615:H2BC4
gene id: 9615:H2BC4
uniprot id: A0A8C0P6N2
uniprot id: H9GWB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:OR2B11
gene id: 9615:OR2B11
uniprot id: A0A8P0NCS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ELP3
gene id: 9615:ELP3
uniprot id: A0A8C0PJ98
uniprot id: A0A8I3MZN4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9615:LOC607889
gene id: 9615:LOC607889
uniprot id: A0A8P0NTC4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:CCZ1
gene id: 9615:CCZ1
uniprot id: A0A8C0NPW4
uniprot id: A0A8I3N3B1
names: Similarity
messages: Belongs to the CCZ1 family.

9615:ETV6
gene id: 9615:ETV6
uniprot id: A0A8C0TML8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:S100A9
gene id: 9615:S100A9
uniprot id: A0A8C0NZI6
uniprot id: A0A8I3MFK0
names: Similarity
messages: Belongs to the S-100 family.

9615:SMARCB1
gene id: 9615:SMARCB1
uniprot id: A0A8C0PI49
uniprot id: A0A8I3PW02
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

9615:OSBPL10
gene id: 9615:OSBPL10
uniprot id: A0A8C0NNG9
uniprot id: A0A8C0RM41
uniprot id: A0A8I3PHZ1
uniprot id: A0A8I3PJG2
names: Similarity
messages: Belongs to the OSBP family.

9615:ALAD
gene id: 9615:ALAD
uniprot id: A0A8C0Q968
uniprot id: A0A8I3N580
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form.

9615:GTF2E2
gene id: 9615:GTF2E2
uniprot id: A0A8C0P9B0
uniprot id: A0A8C0PQ10
uniprot id: A0A8I3P0J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9615:CASP9
gene id: 9615:CASP9
uniprot id: A0A8C0Q619
uniprot id: Q45T68
names: Similarity
messages: Belongs to the peptidase C14A family.

9615:FRG1
gene id: 9615:FRG1
uniprot id: A0A8C0NVG8
uniprot id: E2RKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

9615:FMNL1
gene id: 9615:FMNL1
uniprot id: A0A8C0MEG9
uniprot id: A0A8C0YWZ7
uniprot id: A0A8I3MYK6
names: Similarity
messages: Belongs to the formin homology family.

9615:CMTM1
gene id: 9615:CMTM1
uniprot id: A0A8C0T6C9
uniprot id: A0A8I3NAH3
names: Subcellular Location Annotation
messages: Membrane

9615:PDGFA
gene id: 9615:PDGFA
uniprot id: A0A8C0M6T8
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9615:TMEM176B
gene id: 9615:TMEM176B
uniprot id: A0A8C0PDT6
uniprot id: A0A8I3NBA0
names: Similarity
messages: Belongs to the TMEM176 family.

9615:HSF1
gene id: 9615:HSF1
uniprot id: A0A8C0PQM1
uniprot id: A0A8C0T1S8
uniprot id: A0A8I3NE22
uniprot id: A0A8I3NNB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9615:F3
gene id: 9615:F3
uniprot id: A0A8C0NAL8
uniprot id: Q4W6L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

9615:EXOC4
gene id: 9615:EXOC4
uniprot id: A0A8C0N5P9
uniprot id: A0A8I3NZH6
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9615:GOLPH3L
gene id: 9615:GOLPH3L
uniprot id: A0A8C0S9G5
uniprot id: A0A8I3NX17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9615:ZC2HC1C
gene id: 9615:ZC2HC1C
uniprot id: A0A8C0SKA2
names: Similarity
messages: Belongs to the ZC2HC1 family.

9615:TAPBP
gene id: 9615:TAPBP
uniprot id: Q5TJE4
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with TAP1 and is thus a subunit of the TAP complex. Interaction with TAP1 is TAP2 independent and is required for efficient peptide-TAP interaction. Obligatory mediator for the interaction between newly assembled MHC class I molecules, calreticulin, ERp57 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP (By similarity).
messages: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
messages: The N-terminus is required for efficient association with MHC class I molecule and for a stable interaction between MHC I and calreticulin. Binding to TAP is mediated by the C-terminal region (By similarity).

9615:TMEM132C
gene id: 9615:TMEM132C
uniprot id: A0A8C0TLB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9615:PRPF31
gene id: 9615:PRPF31
uniprot id: A0A8C0M5W5
uniprot id: A0A8I3MUP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

9615:GSG1
gene id: 9615:GSG1
uniprot id: A0A8C0NFG7
uniprot id: A0A8I3PIS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9615:SLC25A48
gene id: 9615:SLC25A48
uniprot id: A0A8C0MPM8
uniprot id: A0A8C0REG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:FCHO1
gene id: 9615:FCHO1
uniprot id: A0A8C0NWM4
uniprot id: A0A8I3PR98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

9615:UCHL3
gene id: 9615:UCHL3
uniprot id: A0A8C0MTB6
uniprot id: A0A8I3PSJ9
uniprot id: A0A8I3Q5H6
uniprot id: A0A8P0NMR4
names: Similarity
messages: Belongs to the peptidase C12 family.

9615:POLG2
gene id: 9615:POLG2
uniprot id: A0A8C0NJ84
names: Subcellular Location Annotation
messages: Mitochondrion

9615:CNN2
gene id: 9615:CNN2
uniprot id: A0A8C0NVP6
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9615:DHODH
gene id: 9615:DHODH
uniprot id: A0A8C0N1H5
uniprot id: A0A8P0P8S9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9615:CYP4F22
gene id: 9615:CYP4F22
uniprot id: A0A8C0P8N5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:MSL3
gene id: 9615:MSL3
uniprot id: A0A8C0MV95
uniprot id: A0A8I3QDH6
names: Subcellular Location Annotation
messages: Nucleus

9615:TXNL4A
gene id: 9615:TXNL4A
uniprot id: A0A8C0M4J1
uniprot id: A0A8C0RB17
uniprot id: A0A8I3MFC7
uniprot id: A0A8I3MGV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9615:HSDL1
gene id: 9615:HSDL1
uniprot id: A0A8C0SUN8
uniprot id: A0A8I3NYZ5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:QPRT
gene id: 9615:QPRT
uniprot id: A0A8C0SLU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

9615:CLDN9
gene id: 9615:CLDN9
uniprot id: A0A8C0Z1H0
uniprot id: A0A8I3MQH4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:ATP6V1H
gene id: 9615:ATP6V1H
uniprot id: A0A8C0RPZ2
uniprot id: A0A8C0TUQ6
uniprot id: A0A8I3PPK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9615:RFC5
gene id: 9615:RFC5
uniprot id: A0A8C0TU87
uniprot id: A0A8I3SAL9
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9615:THOC2
gene id: 9615:THOC2
uniprot id: A0A8C0SXD5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

9615:FGFR1
gene id: 9615:FGFR1
uniprot id: A0A8C0S1Z2
uniprot id: A0A8I3NG90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

9615:TMEM135
gene id: 9615:TMEM135
uniprot id: A0A8C0TH05
uniprot id: A0A8I3MZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane

9615:PGR
gene id: 9615:PGR
uniprot id: Q9GLW0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Expressed in mammary gland and uterus.
messages: Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-349 by ERK1/2-MAPK. Interacts with PRMT2. Isoform A interacts with NCOR2. Isoform B (but not isoform A) interacts with NCOA2 and NCOA1. Isoform B (but not isoform A) interacts with KLF9. Interacts with GTF2B (By similarity).
messages: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.
messages: Nucleus
messages: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity).
messages: Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-303 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-392. Phosphorylation on Ser-303 and Ser-349 also requires induction by hormone. Basal phosphorylation on Ser-200 and Ser-404 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-404 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-303, but not at Ser-200, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-349 by ERK1/2 MAPK is required for interaction with SP1 (By similarity).
messages: Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-392, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-303 (By similarity).
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity).
messages: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.
messages: Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-303 (By similarity).

9615:PPARA
gene id: 9615:PPARA
uniprot id: Q95N78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 and ASXL2. Interacts with PER2. Interacts with SIRT1; the interaction seems to be modulated by NAD(+) levels (By similarity). Interacts with CRY1 and CRY2 (By similarity).
messages: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).
messages: Nucleus

9615:SLC4A5
gene id: 9615:SLC4A5
uniprot id: A0A8C0SMZ3
uniprot id: A0A8I3PBC9
uniprot id: A0A8I3PG85
uniprot id: A0A8P0PM51
uniprot id: A0A8P0TL97
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9615:STAR
gene id: 9615:STAR
uniprot id: A0A8C0NF55
uniprot id: A5A394
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9615:MAOA
gene id: 9615:MAOA
uniprot id: P58027
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).

9615:PTGES2
gene id: 9615:PTGES2
uniprot id: A0A8C0SNP1
uniprot id: B4YY03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

9615:LOC102152706
gene id: 9615:LOC102152706
uniprot id: A0A8C0S7Q9
uniprot id: A0A8I3PVX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9615:SLC5A1
gene id: 9615:SLC5A1
uniprot id: A0A8C0TR03
uniprot id: Q5U9D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9615:DNAJC22
gene id: 9615:DNAJC22
uniprot id: A0A8C0NUH2
uniprot id: A0A8I3S1N8
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

9615:LUC7L2
gene id: 9615:LUC7L2
uniprot id: A0A8C0MCL8
uniprot id: A0A8I3Q8N6
names: Similarity
messages: Belongs to the Luc7 family.

9615:RABGGTB
gene id: 9615:RABGGTB
uniprot id: A0A8C0PLD4
uniprot id: A0A8I3MSX5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9615:FZD4
gene id: 9615:FZD4
uniprot id: A0A8I3RTD0
uniprot id: A0A8P0T5Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

9615:IL37
gene id: 9615:IL37
uniprot id: A0A8C0YXM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9615:SNRPN
gene id: 9615:SNRPN
uniprot id: A0A8C0S1Q3
uniprot id: A0A8I3PH85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9615:SLC27A4
gene id: 9615:SLC27A4
uniprot id: A0A8C0SI53
uniprot id: A0A8I3QRD1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:HTATSF1
gene id: 9615:HTATSF1
uniprot id: A0A8I3QS20
uniprot id: A0A8P0NQB0
names: Similarity
messages: Belongs to the HTATSF1 family.

9615:BBS7
gene id: 9615:BBS7
uniprot id: A0A8C0SRU7
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9615:KRT124
gene id: 9615:KRT124
uniprot id: A0A8P0TN42
names: Similarity
messages: Belongs to the intermediate filament family.

9615:SIX6
gene id: 9615:SIX6
uniprot id: A0A8C0QBD7
uniprot id: A0A8I3PIU9
names: Subcellular Location Annotation
messages: Nucleus

9615:MAK16
gene id: 9615:MAK16
uniprot id: A0A8C0SNQ3
uniprot id: A0A8I3NK69
names: Similarity
messages: Belongs to the MAK16 family.

9615:NR5A2
gene id: 9615:NR5A2
uniprot id: A0A8C0S7V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9615:NUDT2
gene id: 9615:NUDT2
uniprot id: A0A8C0S0Q8
uniprot id: A0A8I3PR56
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9615:GALT
gene id: 9615:GALT
uniprot id: A0A8C0MBX6
uniprot id: A0A8I3PT77
uniprot id: A0A8P0N512
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

9615:ITGA2B
gene id: 9615:ITGA2B
uniprot id: Q9TUN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:AQP4
gene id: 9615:AQP4
uniprot id: A0A8I3RX19
uniprot id: A0A8P0PLW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9615:OR7A52
gene id: 9615:OR7A52
uniprot id: A0A8C0SL80
uniprot id: A0A8I3S457
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:BZW2
gene id: 9615:BZW2
uniprot id: A0A8I3NCC5
uniprot id: A0A8P0S883
names: Similarity
messages: Belongs to the BZW family.

9615:ST8SIA2
gene id: 9615:ST8SIA2
uniprot id: A0A8C0M473
uniprot id: A2BCP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:FFAR1
gene id: 9615:FFAR1
uniprot id: A0A8C0RBM8
uniprot id: A0A8I3MH22
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:ADGRL3
gene id: 9615:ADGRL3
uniprot id: A0A8I3NTN3
uniprot id: A0A8I3NW47
uniprot id: A0A8P0NYX0
uniprot id: A0A8P0S888
names: Subcellular Location Annotation
messages: Membrane

9615:RNPC3
gene id: 9615:RNPC3
uniprot id: A0A8C0NW40
uniprot id: A0A8I3NH24
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

9615:PSMC6
gene id: 9615:PSMC6
uniprot id: A0A8C0M7Z2
uniprot id: A0A8I3RRR7
names: Similarity
messages: Belongs to the AAA ATPase family.

9615:KDELR3
gene id: 9615:KDELR3
uniprot id: A0A8C0QBK4
uniprot id: A0A8I3PJT5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:GNG11
gene id: 9615:GNG11
uniprot id: A0A8C0NGJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:PUS10
gene id: 9615:PUS10
uniprot id: A0A8P0S8R3
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

9615:GLIS3
gene id: 9615:GLIS3
uniprot id: A0A8C0N5P6
uniprot id: A0A8I3MG80
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9615:CDC20
gene id: 9615:CDC20
uniprot id: A0A8C0QF33
uniprot id: A0A8I3NZ86
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9615:CRYGA
gene id: 9615:CRYGA
uniprot id: A0A8C0S135
uniprot id: A9JPX6
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9615:DPF2
gene id: 9615:DPF2
uniprot id: A0A8C0T5U5
names: Similarity
messages: Belongs to the requiem/DPF family.

9615:NSUN4
gene id: 9615:NSUN4
uniprot id: A0A8I3P7P3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9615:GPR39
gene id: 9615:GPR39
uniprot id: A0A8I3RTK7
uniprot id: A0A8P0SAK7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:CA11
gene id: 9615:CA11
uniprot id: A0A8C0NCY7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9615:KCNE2
gene id: 9615:KCNE2
uniprot id: A0A8C0T7F7
uniprot id: Q864T0
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9615:PA2G4
gene id: 9615:PA2G4
uniprot id: A0A8C0Q8X0
uniprot id: A0A8I3MYE2
names: Similarity
messages: Belongs to the peptidase M24 family.

9615:TMEM97
gene id: 9615:TMEM97
uniprot id: A0A8I3NWV4
uniprot id: A0A8P0TJE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM97/sigma-2 receptor family.
messages: Endoplasmic reticulum membrane
messages: Interacts with NPC1.
messages: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane

9615:LOC476445
gene id: 9615:LOC476445
uniprot id: A0A8C0SK98
uniprot id: E2QTH3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9615:SF3B3
gene id: 9615:SF3B3
uniprot id: A0A8C0SSU9
uniprot id: A0A8I3MQG0
names: Subcellular Location Annotation
messages: Nucleus

9615:LOC482182
gene id: 9615:LOC482182
uniprot id: A0A8C0PPL8
uniprot id: A0A8I3NE83
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:HRH4
gene id: 9615:HRH4
uniprot id: A0A8I3NPW0
uniprot id: A0A8P0NQT4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:LOC479708
gene id: 9615:LOC479708
uniprot id: A0A8C0Q8T5
uniprot id: A0A8I3MMI6
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.

9615:MRPL15
gene id: 9615:MRPL15
uniprot id: A0A8C0TR33
uniprot id: A0A8I3PS17
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9615:PRAF2
gene id: 9615:PRAF2
uniprot id: A0A8C0S9V3
uniprot id: A0A8I3Q651
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9615:THUMPD3
gene id: 9615:THUMPD3
uniprot id: A0A8C0TWU7
uniprot id: A0A8I3NEC2
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9615:USP1
gene id: 9615:USP1
uniprot id: A0A8C0SPV6
uniprot id: A0A8I3RSI1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9615:PRKAR1A
gene id: 9615:PRKAR1A
uniprot id: A0A8C0S5L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9615:SEC31A
gene id: 9615:SEC31A
uniprot id: A0A8C0N6Z6
uniprot id: A0A8C0N8Y4
uniprot id: A0A8C0Z5D1
uniprot id: A0A8C0Z5E9
uniprot id: A0A8C0Z5G4
uniprot id: A0A8I3P7Z9
uniprot id: A0A8I3S449
uniprot id: A0A8I3S4B6
uniprot id: A0A8P0T620
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

9615:NOVA1
gene id: 9615:NOVA1
uniprot id: A0A8C0MZ31
uniprot id: A0A8C0S194
uniprot id: A0A8C0S1D5
uniprot id: A0A8I3N7C5
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PTBP2; the interaction is direct.
messages: Nucleus

9615:GABRG2
gene id: 9615:GABRG2
uniprot id: A0A8C0NGN4
uniprot id: A0A8C0PV63
uniprot id: A0A8I3MDZ2
uniprot id: E2RSQ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:NEURL2
gene id: 9615:NEURL2
uniprot id: A0A8C0QCJ2
uniprot id: A0A8I3P462
names: Subcellular Location Annotation
messages: Cytoplasm

9615:BTNL9
gene id: 9615:BTNL9
uniprot id: A0A8C0QJ13
uniprot id: A0A8I3MZ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9615:ZIC5
gene id: 9615:ZIC5
uniprot id: A0A8P0N8K0
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9615:JRKL
gene id: 9615:JRKL
uniprot id: A0A8C0NZ51
uniprot id: A0A8I3P7F5
names: Subcellular Location Annotation
messages: Nucleus

9615:TMEM198
gene id: 9615:TMEM198
uniprot id: A0A8C0RJ22
uniprot id: A0A8I3QBJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9615:OR51M1
gene id: 9615:OR51M1
uniprot id: A0A8C0NK56
uniprot id: A0A8I3P609
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CCDC153
gene id: 9615:CCDC153
uniprot id: A0A8C0T7V6
names: Similarity
messages: Belongs to the UPF0610 family.

9615:RBBP5
gene id: 9615:RBBP5
uniprot id: A0A8C0MY00
uniprot id: A0A8C0SYR7
uniprot id: A0A8I3PRI4
names: Subcellular Location Annotation
messages: Nucleus

9615:EFNA5
gene id: 9615:EFNA5
uniprot id: A0A8C0MWS8
uniprot id: A0A8C0SCQ5
uniprot id: A0A8I3MD88
uniprot id: A0A8I3RQW1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:BLOC1S2
gene id: 9615:BLOC1S2
uniprot id: A0A8C0T552
names: Similarity
messages: Belongs to the BLOC1S2 family.

9615:CORO1A
gene id: 9615:CORO1A
uniprot id: A0A8C0PRK9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

9615:ATP1A3
gene id: 9615:ATP1A3
uniprot id: A0A8C0QH55
uniprot id: A0A8I3MHA2
uniprot id: A0A8I3MIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9615:RO60
gene id: 9615:RO60
uniprot id: A0A8I3PKJ0
uniprot id: A0A8P0NZ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

9615:RRAGB
gene id: 9615:RRAGB
uniprot id: A0A8C0TAR4
uniprot id: A0A8C0Z2K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9615:EDEM3
gene id: 9615:EDEM3
uniprot id: A0A8P0SI84
uniprot id: A0A8P0SUA8
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9615:ZNF687
gene id: 9615:ZNF687
uniprot id: A0A8C0MLL2
uniprot id: A0A8C0MS87
uniprot id: A0A8I3PKD1
uniprot id: A0A8I3PRI1
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9615:EIF4E2
gene id: 9615:EIF4E2
uniprot id: A0A8C0TQV7
uniprot id: A0A8I3PNW0
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9615:ATF1
gene id: 9615:ATF1
uniprot id: A0A8C0PHZ7
uniprot id: A0A8I3NUJ6
uniprot id: A0A8I3RZ79
uniprot id: A0A8P0T2W6
names: Subcellular Location Annotation
messages: Nucleus

9615:CYP2D15
gene id: 9615:CYP2D15
uniprot id: Q29473
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.
messages: Liver. Also detected in several other tissues.
messages: Microsome membrane

9615:INTS14
gene id: 9615:INTS14
uniprot id: A0A8C0NBK9
uniprot id: A0A8I3PNL5
uniprot id: A0A8I3Q929
uniprot id: A0A8P0SLI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9615:MFSD8
gene id: 9615:MFSD8
uniprot id: A0A8C0S8U7
uniprot id: A0A8I3PTN1
names: Subcellular Location Annotation
messages: Membrane

9615:DLGAP1
gene id: 9615:DLGAP1
uniprot id: A0A8C0MS78
uniprot id: A0A8C0MXX8
uniprot id: A0A8C0RGX6
uniprot id: A0A8I3MK13
uniprot id: A0A8I3MPX1
uniprot id: A0A8I3N4Y0
names: Similarity
messages: Belongs to the SAPAP family.

9615:LOC100687285
gene id: 9615:LOC100687285
uniprot id: A0A8C0S4Y9
uniprot id: J9NZS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9615:BCLAF1
gene id: 9615:BCLAF1
uniprot id: A0A8C0RBW6
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9615:GRIA1
gene id: 9615:GRIA1
uniprot id: A0A8C0MH98
uniprot id: A0A8C0MHS5
uniprot id: A0A8I3MYK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9615:PDIA2
gene id: 9615:PDIA2
uniprot id: A0A8C0MVV7
uniprot id: A0A8I3QQT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9615:XDH
gene id: 9615:XDH
uniprot id: A0A8C0NJ24
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Homodimer. Interacts with BTN1A1.
messages: Peroxisome

9615:MRPS18B
gene id: 9615:MRPS18B
uniprot id: A0A8C0YYK3
uniprot id: A0A8I3N171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

9615:E2F4
gene id: 9615:E2F4
uniprot id: A0A8I3N364
uniprot id: A0A8P0NPJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9615:MAS1
gene id: 9615:MAS1
uniprot id: A0A8C0Z5A8
uniprot id: H6TB52
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:GRHL2
gene id: 9615:GRHL2
uniprot id: A0A8C0Q8W8
uniprot id: A0A8I3RV92
names: Subcellular Location Annotation
messages: Nucleus

9615:SYN1
gene id: 9615:SYN1
uniprot id: A0A8I3QAQ3
uniprot id: A0A8P0SJE4
names: Similarity
messages: Belongs to the synapsin family.

9615:GPC6
gene id: 9615:GPC6
uniprot id: A0A8C0QGN7
uniprot id: A0A8I3N3M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9615:TYMS
gene id: 9615:TYMS
uniprot id: A0A8C0PYK6
uniprot id: A0A8I3RRU2
names: Similarity
messages: Belongs to the thymidylate synthase family.

9615:ICAM3
gene id: 9615:ICAM3
uniprot id: A0A8P0THL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9615:MYLK2
gene id: 9615:MYLK2
uniprot id: A0A8C0Z4A7
uniprot id: A0A8I3P9R3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May interact with centrin.

9615:TGFBR2
gene id: 9615:TGFBR2
uniprot id: A0A8C0RMM0
uniprot id: A0A8I3PL32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

9615:MDH1B
gene id: 9615:MDH1B
uniprot id: A0A8C0TZE0
uniprot id: A0A8I3PH80
uniprot id: A0A8P0SI95
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9615:SLC2A1
gene id: 9615:SLC2A1
uniprot id: A0A8C0QL50
uniprot id: A0A8I3NRK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane
messages: Photoreceptor inner segment

9615:SLC25A12
gene id: 9615:SLC25A12
uniprot id: A0A8C0TWK1
uniprot id: A0A8C0TZ22
uniprot id: A0A8I3PZY8
uniprot id: A0A8I3Q392
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:CNNM1
gene id: 9615:CNNM1
uniprot id: A0A8C0TTG4
uniprot id: A0A8C0Z7E5
uniprot id: A0A8I3Q561
uniprot id: A0A8I3QBL6
uniprot id: A0A8I3SCT6
uniprot id: A0A8P0TGH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9615:PI4K2A
gene id: 9615:PI4K2A
uniprot id: A0A8P0NUC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9615:GPRIN3
gene id: 9615:GPRIN3
uniprot id: A0A8P0NC12
names: Function
messages: May be involved in neurite outgrowth.

9615:SLC8A1
gene id: 9615:SLC8A1
uniprot id: P23685
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by micromolar levels of Ca(2+). In the absence of regulatory Ca(2+), channels open rapidly, and then inactivate rapidly. Inactivation is enhanced by Na(+) and is inhibited by micromolar levels of Ca(2+).
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cardiac sarcolemma (at protein level).
messages: Cell membrane
messages: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1700476, PubMed:1785844, PubMed:9486131, PubMed:17962412). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions (By similarity).
messages: The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions (PubMed:16774926, PubMed:19332552, PubMed:22768191). The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange (PubMed:17962412).
messages: sarcolemma

9615:SERPINA4
gene id: 9615:SERPINA4
uniprot id: A0A8C0QCK2
uniprot id: A0A8I3N493
names: Similarity
messages: Belongs to the serpin family.

9615:VGLL4
gene id: 9615:VGLL4
uniprot id: A0A8C0M5H1
uniprot id: A0A8C0MAH0
uniprot id: A0A8C0TLJ8
uniprot id: A0A8I3MW40
uniprot id: A0A8I3RUI9
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

9615:NPB
gene id: 9615:NPB
uniprot id: A0A8C0PJT5
uniprot id: A0A8I3NAS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropeptide B/W family.
messages: Secreted

9615:LIPT1
gene id: 9615:LIPT1
uniprot id: A0A8C0NSY5
uniprot id: A0A8I3PAB4
names: Similarity
messages: Belongs to the LplA family.

9615:GPR137
gene id: 9615:GPR137
uniprot id: A0A8C0RI50
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9615:MED1
gene id: 9615:MED1
uniprot id: A0A8C0MR58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9615:SIX4
gene id: 9615:SIX4
uniprot id: A0A8C0QBK0
names: Subcellular Location Annotation
messages: Nucleus

9615:ZFPM2
gene id: 9615:ZFPM2
uniprot id: A0A8C0PBQ0
uniprot id: B3FXQ6
names: Subcellular Location Annotation
messages: Nucleus

9615:TRAPPC6B
gene id: 9615:TRAPPC6B
uniprot id: A0A8C0M3V3
uniprot id: A0A8I3N5C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9615:VDAC3
gene id: 9615:VDAC3
uniprot id: A0A8C0P3D0
uniprot id: A0A8C0Q760
uniprot id: A0A8I3RT18
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

9615:ZMYND10
gene id: 9615:ZMYND10
uniprot id: A0A8C0N6K9
uniprot id: A0A8I3PGZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Dynein axonemal particle
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
messages: centriolar satellite

9615:EXOC8
gene id: 9615:EXOC8
uniprot id: A0A8C0NJH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

9615:GNG5
gene id: 9615:GNG5
uniprot id: A0A8C0YWB5
uniprot id: A0A8I3RRM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:LAMP2
gene id: 9615:LAMP2
uniprot id: A0A8C0SR91
uniprot id: A0A8I3S2Z8
uniprot id: A0A8P0NJT0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9615:MRPL40
gene id: 9615:MRPL40
uniprot id: A0A8P0PFV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9615:LOX
gene id: 9615:LOX
uniprot id: A0A8C0Q980
uniprot id: A0A8I3N9H6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9615:SLC7A4
gene id: 9615:SLC7A4
uniprot id: A0A8C0PB92
names: Subcellular Location Annotation
messages: Membrane

9615:ABCC6
gene id: 9615:ABCC6
uniprot id: A0A8C0PRX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9615:MCCC2
gene id: 9615:MCCC2
uniprot id: A0A8C0M6Y4
uniprot id: A0A8I3MA32
names: Similarity
messages: Belongs to the AccD/PCCB family.

9615:DHDH
gene id: 9615:DHDH
uniprot id: Q9TV68
names: Activity Regulation
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the Gfo/Idh/MocA family.
messages: Homodimer.
messages: Liver and kidney.
messages: Strongly inhibited by isoascorbic acid, 4-hydroxyacetophenone and 4-chloromercuriphenylsulphonate. Stimulated by various salts.

9615:SARDH
gene id: 9615:SARDH
uniprot id: A0A8C0LWN2
uniprot id: A0A8I3NBY7
names: Similarity
messages: Belongs to the GcvT family.

9615:CDK5RAP3
gene id: 9615:CDK5RAP3
uniprot id: A0A8C0M3W4
uniprot id: A0A8I3P749
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9615:VASP
gene id: 9615:VASP
uniprot id: P50551
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Ena/VASP family.
messages: Cytoplasm
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity).
messages: Homotetramer. Interacts with PFN1, PFN2, LPP, ACTN1 and ACTG1. Interacts, via the EVH1 domain, with the Pro-rich regions of ZYX. This interaction is important for targeting to focal adhesions and the formation of actin-rich structures at the apical surface of cells. Interacts, via the EVH1 domain, with the Pro-rich domain of Listeria monocytogenes actA. Interacts with APBB1IP. Interacts, via the Pro-rich domain, with the C-terminal SH3 domain of DNMBP. Interacts weakly with MEFV (By similarity).
messages: Major substrate for cAMP-dependent (PKA) and cGMP-dependent protein kinase (PKG) in platelets. The preferred site for PKA is Ser-160, the preferred site for PKG/PRKG1, Ser-242. In ADP-activated platelets, phosphorylation by PKA or PKG on Ser-160 leads to fibrinogen receptor inhibition. Phosphorylation on Thr-281 requires prior phosphorylation on Ser-160 and Ser-242. In response to phorbol ester (PMA) stimulation, phosphorylated by PKC/PRKCA. In response to thrombin, phosphorylated by both PKC and ROCK1. Phosphorylation at Thr-281 by AMPK does not require prior phosphorylation at Ser-160 or Ser-242. Phosphorylation at Ser-160 by PKA is required for localization to the tight junctions in epithelial cells. Phosphorylation modulates F-actin binding, actin filament elongation and platelet activation. Phosphorylation at Ser-326 by AMPK also alters actin filament binding. Carbon monoxide (CO) promotes phosphorylation at Ser-160, while nitric oxide (NO) promotes phosphorylation at Ser-160, but also at Ser-242 (By similarity).
messages: The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.
messages: The WH1 domain mediates interaction with XIRP1.
messages: cytoskeleton
messages: filopodium membrane
messages: focal adhesion
messages: lamellipodium membrane
messages: tight junction

9615:CAPN6
gene id: 9615:CAPN6
uniprot id: A0A8C0SR05
uniprot id: A0A8I3PJW4
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:VTA1
gene id: 9615:VTA1
uniprot id: A0A8C0PW95
uniprot id: A0A8I3N6U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9615:MRPS30
gene id: 9615:MRPS30
uniprot id: A0A8P0SMJ8
names: Subcellular Location Annotation
messages: Mitochondrion

9615:IPO4
gene id: 9615:IPO4
uniprot id: A0A8C0PZF2
names: Subcellular Location Annotation
messages: Cytoplasm

9615:RAD50
gene id: 9615:RAD50
uniprot id: A0A8C0Q7A8
uniprot id: A0A8I3NID5
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9615:SRPX
gene id: 9615:SRPX
uniprot id: A0A8I3PN65
uniprot id: A0A8I3PTH7
uniprot id: A0A8P0SII2
uniprot id: A0A8P0ST72
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PEG3
gene id: 9615:PEG3
uniprot id: A0A8P0STH4
names: Subcellular Location Annotation
messages: Nucleus

9615:SRP72
gene id: 9615:SRP72
uniprot id: P33731
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6413076). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:6413076). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:8388879, PubMed:6413076). Can bind 7SL RNA with low affinity (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Heterodimer with SRP68 (PubMed:8388879, PubMed:6413076). SRP68-SRP72 heterodimer formation is stabilized by the presence of 7SL RNA (PubMed:8388879, PubMed:6413076). Component of a signal recognition particle consisting of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:6938958, PubMed:6413076). Within the SRP complex, interacts with SRP68 (via C-terminus) (PubMed:8388879, PubMed:6413076).

9615:CDH1
gene id: 9615:CDH1
uniprot id: F1PAA9
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
messages: Cell membrane
messages: During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 (By similarity). Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm (By similarity). The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway (By similarity). Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system (By similarity). The gamma-secretase-mediated cleavage promotes disassembly of adherens junctions (By similarity). During development of the cochlear organ of Corti, cleavage by ADAM10 at adherens junctions promotes pillar cell separation (By similarity).
messages: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
messages: Endosome
messages: Homodimer; disulfide-linked (By similarity). Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1, beta-catenin/CTNNB1 or gamma-catenin/JUP, and potentially alpha-catenin/CTNNA1; the complex is located to adherens junctions (By similarity). Interacts with the TRPV4 and CTNNB1 complex (By similarity). Interacts with CTNND1 (By similarity). The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex (By similarity). Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1 (By similarity). Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs) (By similarity). Interacts with AJAP1 and DLGAP5 (By similarity). Interacts with TBC1D2 (By similarity). Interacts with LIMA1 (By similarity). Interacts with CAV1 (By similarity). Interacts with PIP5K1C (By similarity). Interacts with RAB8B (By similarity). Interacts with DDR1; this stabilizes CDH1 at the cell surface and inhibits its internalization (By similarity). Interacts with RAPGEF2 (PubMed:10873669). Interacts with KLRG1 (By similarity). Forms a ternary complex composed of ADAM10, CADH1 and EPHA4; within the complex, CADH1 is cleaved by ADAM10 which disrupts adherens junctions (By similarity). Interacts with SPEF1 (By similarity). Interacts with CTNNB1 and PKP2 (By similarity).
messages: N-glycosylation at Asn-639 is essential for expression, folding and trafficking. Addition of bisecting N-acetylglucosamine by MGAT3 modulates its cell membrane location (By similarity).
messages: O-glycosylated. O-manosylated by TMTC1, TMTC2, TMTC3 or TMTC4. Thr-287 and Thr-511 are O-mannosylated by TMTC2 or TMTC4 but not TMTC1 or TMTC3.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
messages: Ubiquitinated by a SCF complex containing SKP2, which requires prior phosphorylation by CK1/CSNK1A1. Ubiquitinated by CBLL1/HAKAI, requires prior phosphorylation at Tyr-757 (By similarity).
messages: adherens junction
messages: trans-Golgi network

9615:ACD
gene id: 9615:ACD
uniprot id: A0A8P0NM37
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9615:HNRNPDL
gene id: 9615:HNRNPDL
uniprot id: A0A8C0NFT1
uniprot id: A0A8I3NY09
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:BCL9
gene id: 9615:BCL9
uniprot id: A0A8C0SZL8
uniprot id: A0A8I3NP63
uniprot id: A0A8P0SFT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9615:LOC607817
gene id: 9615:LOC607817
uniprot id: A0A8C0RGA2
uniprot id: A0A8I3Q4W8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:CUL4A
gene id: 9615:CUL4A
uniprot id: A0A8C0RRK5
names: Similarity
messages: Belongs to the cullin family.

9615:SHCBP1
gene id: 9615:SHCBP1
uniprot id: A0A8C0S4I3
uniprot id: A0A8I3NXW0
names: Subcellular Location Annotation
messages: spindle

9615:ANKRD13D
gene id: 9615:ANKRD13D
uniprot id: A0A8C0SDF0
uniprot id: A0A8I3NCP1
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9615:LOC481634
gene id: 9615:LOC481634
uniprot id: A0A8C0QCS0
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9615:ARHGEF12
gene id: 9615:ARHGEF12
uniprot id: A0A8C0LY91
uniprot id: A0A8I3NH44
uniprot id: A0A8I3NID3
uniprot id: A0A8I3NRY3
uniprot id: A0A8P0P669
uniprot id: A0A8P0PCJ9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9615:EPC1
gene id: 9615:EPC1
uniprot id: A0A8C0NZK9
uniprot id: A0A8I3NEK3
uniprot id: A0A8I3RX50
uniprot id: A0A8P0TP59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9615:PLAC1
gene id: 9615:PLAC1
uniprot id: A0A8I3PNQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9615:CLRN1
gene id: 9615:CLRN1
uniprot id: A0A8C0N1Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9615:BMS1
gene id: 9615:BMS1
uniprot id: A0A8P0SCF9
names: Subcellular Location Annotation
messages: nucleolus

9615:WDR1
gene id: 9615:WDR1
uniprot id: A0A5K1UTD0
names: Subcellular Location Annotation
messages: COPI-coated vesicle membrane

9615:MYH16
gene id: 9615:MYH16
uniprot id: A0A8C0S3A0
uniprot id: A0A8I3RT35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9615:BICD2
gene id: 9615:BICD2
uniprot id: A0A8C0PQ84
uniprot id: A0A8C0RAA3
uniprot id: A0A8I3PLU4
uniprot id: A0A8I3PLZ6
names: Similarity
messages: Belongs to the BicD family.

9615:SLC11A2
gene id: 9615:SLC11A2
uniprot id: A0A8C0N689
uniprot id: A0A8I3RZ10
uniprot id: A0A8P0SD71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.