9597:MINDY4
gene id: 9597:MINDY4
uniprot id: A0A2R8ZGQ9
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9597:MPHOSPH10
gene id: 9597:MPHOSPH10
uniprot id: A0A2R9ARM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9597:PPIL1
gene id: 9597:PPIL1
uniprot id: A0A2R9ATX8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9597:SEPSECS
gene id: 9597:SEPSECS
uniprot id: A0A2R9BML0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9597:MPV17L2
gene id: 9597:MPV17L2
uniprot id: A0A2R9C5K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9597:IRAK1BP1
gene id: 9597:IRAK1BP1
uniprot id: A0A2R9B404
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

9597:SHBG
gene id: 9597:SHBG
uniprot id: A0A2R9C134
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:P2RX3
gene id: 9597:P2RX3
uniprot id: A0A2R9BII3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9597:CDK5RAP3
gene id: 9597:CDK5RAP3
uniprot id: A0A2R9A907
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9597:SPI1
gene id: 9597:SPI1
uniprot id: A0A2R9BGS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:FER1L5
gene id: 9597:FER1L5
uniprot id: A0A2R9A500
names: Similarity
messages: Belongs to the ferlin family.

9597:ARHGEF1
gene id: 9597:ARHGEF1
uniprot id: A0A2R9C015
names: Subcellular Location Annotation
messages: Membrane

9597:LPAR5
gene id: 9597:LPAR5
uniprot id: A0A2R8ZEH5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:IDO1
gene id: 9597:IDO1
uniprot id: A0A2R9A3G1
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9597:AMER3
gene id: 9597:AMER3
uniprot id: A0A2R9AY54
names: Similarity
messages: Belongs to the Amer family.

9597:SYNCRIP
gene id: 9597:SYNCRIP
uniprot id: A0A2R9AVY9
names: Subcellular Location Annotation
messages: Cytoplasm

9597:LOC100968432
gene id: 9597:LOC100968432
uniprot id: A0A2R9A9R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9597:CTBP2
gene id: 9597:CTBP2
uniprot id: A0A2R9AUN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9597:STX16
gene id: 9597:STX16
uniprot id: A0A2R9BGQ5
names: Similarity
messages: Belongs to the syntaxin family.

9597:NCOA7
gene id: 9597:NCOA7
uniprot id: A0A2R9BX20
names: Similarity
messages: Belongs to the OXR1 family.

9597:METTL14
gene id: 9597:METTL14
uniprot id: A0A2R9A9D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MT-A70-like family.
messages: Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.
messages: Nucleus
messages: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells.

9597:FAM174A
gene id: 9597:FAM174A
uniprot id: A0A2R8ZMM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9597:COPS8
gene id: 9597:COPS8
uniprot id: A0A2R8ZZD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9597:SPRTN
gene id: 9597:SPRTN
uniprot id: A0A2R9BCR3
uniprot id: A0A2R9BGJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9597:LUC7L3
gene id: 9597:LUC7L3
uniprot id: A0A2R8ZPS0
names: Similarity
messages: Belongs to the Luc7 family.

9597:PRDM14
gene id: 9597:PRDM14
uniprot id: A0A2R8ZS07
names: Subcellular Location Annotation
messages: Nucleus

9597:CA11
gene id: 9597:CA11
uniprot id: A0A2R9A1F0
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9597:ERCC5
gene id: 9597:ERCC5
uniprot id: A0A2R9C1V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

9597:VAMP5
gene id: 9597:VAMP5
uniprot id: A0A2R9AEV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9597:EID2B
gene id: 9597:EID2B
uniprot id: A0A2R8ZJ03
names: Subcellular Location Annotation
messages: Nucleus

9597:PGLYRP3
gene id: 9597:PGLYRP3
uniprot id: A0A2R9CMU3
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9597:HAUS1
gene id: 9597:HAUS1
uniprot id: A0A2R9AWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9597:DDX18
gene id: 9597:DDX18
uniprot id: A0A2R9AT87
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9597:LDLRAD4
gene id: 9597:LDLRAD4
uniprot id: A0A2R8Z883
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9597:UBE4B
gene id: 9597:UBE4B
uniprot id: A0A2R9BSS6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

9597:KLHL21
gene id: 9597:KLHL21
uniprot id: A0A2R9AC80
names: Subcellular Location Annotation
messages: spindle

9597:CYP4F3
gene id: 9597:CYP4F3
uniprot id: A0A2R9BI89
uniprot id: A0A2R9BS15
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:MAB21L1
gene id: 9597:MAB21L1
uniprot id: A0A2R9AQ93
names: Similarity
messages: Belongs to the mab-21 family.

9597:CKAP2L
gene id: 9597:CKAP2L
uniprot id: A0A2R9A109
names: Similarity
messages: Belongs to the CKAP2 family.

9597:CTNS
gene id: 9597:CTNS
uniprot id: A0A2R9BNZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

9597:BRF2
gene id: 9597:BRF2
uniprot id: A0A2R9APN8
names: Subcellular Location Annotation
messages: Nucleus

9597:TPK1
gene id: 9597:TPK1
uniprot id: A0A2R9CLA2
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9597:CENPL
gene id: 9597:CENPL
uniprot id: A0A2R8ZFA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

9597:SEC11A
gene id: 9597:SEC11A
uniprot id: A0A2R9C232
uniprot id: A0A2R9C2J8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:RAB29
gene id: 9597:RAB29
uniprot id: A0A2R8ZEE0
uniprot id: A0A2R8ZEE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9597:AARSD1
gene id: 9597:AARSD1
uniprot id: A0A2R9AN71
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

9597:LOC100982351
gene id: 9597:LOC100982351
uniprot id: A0A2R9BWJ1
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9597:MKS1
gene id: 9597:MKS1
uniprot id: A0A2R8ZTG8
names: Subcellular Location Annotation
messages: cilium basal body

9597:LOC100967935
gene id: 9597:LOC100967935
uniprot id: A0A2R9ALS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:FGF9
gene id: 9597:FGF9
uniprot id: A0A2R8ZBT9
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:CALHM5
gene id: 9597:CALHM5
uniprot id: A0A2R9BVY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9597:DDX50
gene id: 9597:DDX50
uniprot id: A0A2R9CC31
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9597:LOC100979972
gene id: 9597:LOC100979972
uniprot id: P61639
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9597:BTG4
gene id: 9597:BTG4
uniprot id: A0A2R9CQ48
names: Similarity
messages: Belongs to the BTG family.

9597:LOC100975612
gene id: 9597:LOC100975612
uniprot id: A0A2R9C6F8
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9597:SENP8
gene id: 9597:SENP8
uniprot id: A0A2R8Z824
names: Similarity
messages: Belongs to the peptidase C48 family.

9597:CAMK2N2
gene id: 9597:CAMK2N2
uniprot id: A0A2R8ZH27
names: Similarity
messages: Belongs to the CAMK2N family.

9597:BMX
gene id: 9597:BMX
uniprot id: A0A2R9BZZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9597:GJA3
gene id: 9597:GJA3
uniprot id: A0A2R8ZQN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:ZACN
gene id: 9597:ZACN
uniprot id: A0A2R9BAS2
names: Subcellular Location Annotation
messages: Membrane

9597:XG
gene id: 9597:XG
uniprot id: A0A2R9AHM3
uniprot id: A0A2R9APR0
names: Similarity
messages: Belongs to the CD99 family.

9597:MFN2
gene id: 9597:MFN2
uniprot id: A0A2R8ZXY7
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9597:SEPTIN2
gene id: 9597:SEPTIN2
uniprot id: A0A2R9B3R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

9597:TIMM8A
gene id: 9597:TIMM8A
uniprot id: A0A2R8ZRL5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9597:CDNF
gene id: 9597:CDNF
uniprot id: A0A2R8ZVC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9597:CFL2
gene id: 9597:CFL2
uniprot id: A0A2R8Z9R1
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9597:HYAL3
gene id: 9597:HYAL3
uniprot id: A0A2R9BA36
uniprot id: A0A2R9BCC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.
messages: Membrane
messages: acrosome

9597:KIF20A
gene id: 9597:KIF20A
uniprot id: A0A2R8Z7U8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:PKIG
gene id: 9597:PKIG
uniprot id: A0A2R9CGG5
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9597:SLC41A3
gene id: 9597:SLC41A3
uniprot id: A0A2R9BKS9
uniprot id: A0A2R9BTU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9597:SGTA
gene id: 9597:SGTA
uniprot id: A0A2R8ZHE2
names: Similarity
messages: Belongs to the SGT family.

9597:SATB1
gene id: 9597:SATB1
uniprot id: A0A2R8ZTX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9597:EDA2R
gene id: 9597:EDA2R
uniprot id: A0A2R8ZCJ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100979261
gene id: 9597:LOC100979261
uniprot id: A0A2R8ZVB5
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.

9597:LOC103786072
gene id: 9597:LOC103786072
uniprot id: A0A2R9A3G6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

9597:LAMB1
gene id: 9597:LAMB1
uniprot id: A0A2R9A2B3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9597:ENPP1
gene id: 9597:ENPP1
uniprot id: A0A2R9AIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9597:LGR5
gene id: 9597:LGR5
uniprot id: A0A2R9AWL1
uniprot id: A0A2R9B2G8
names: Subcellular Location Annotation
messages: Membrane

9597:IFNAR1
gene id: 9597:IFNAR1
uniprot id: A0A2R8ZEG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9597:LOC100969204
gene id: 9597:LOC100969204
uniprot id: A0A2R9CIX3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

9597:VMA21
gene id: 9597:VMA21
uniprot id: A0A2R8Z5P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

9597:SDR9C7
gene id: 9597:SDR9C7
uniprot id: A0A2R8Z9Y3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:UBE2A
gene id: 9597:UBE2A
uniprot id: A0A2R8Z7N0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:SNX3
gene id: 9597:SNX3
uniprot id: A0A2R9AMC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

9597:TSPAN2
gene id: 9597:TSPAN2
uniprot id: A0A2R8ZZA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:GJB1
gene id: 9597:GJB1
uniprot id: A0A2R8ZC06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:HSP90B1
gene id: 9597:HSP90B1
uniprot id: A0A2R9BR22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9597:PDK4
gene id: 9597:PDK4
uniprot id: A0A2R8ZSG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9597:TRNAU1AP
gene id: 9597:TRNAU1AP
uniprot id: A0A2R9AW67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9597:LOC100985167
gene id: 9597:LOC100985167
uniprot id: A0A2R8ZQL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ACTA1
gene id: 9597:ACTA1
uniprot id: A0A2R9AZU8
names: Similarity
messages: Belongs to the actin family.

9597:CDC42SE1
gene id: 9597:CDC42SE1
uniprot id: A0A2R9BGD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9597:POU2F3
gene id: 9597:POU2F3
uniprot id: A0A2R9BHB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

9597:EBAG9
gene id: 9597:EBAG9
uniprot id: A0A2R9B0N6
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

9597:GMDS
gene id: 9597:GMDS
uniprot id: A0A2R8ZSP9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9597:KCNA1
gene id: 9597:KCNA1
uniprot id: A0A2R8ZFZ7
names: Subcellular Location Annotation
messages: Membrane

9597:ORC3
gene id: 9597:ORC3
uniprot id: A0A2R9BMI2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus

9597:ITPKB
gene id: 9597:ITPKB
uniprot id: A0A2R9AXD5
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9597:ANAPC13
gene id: 9597:ANAPC13
uniprot id: A0A2R9ACC0
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9597:CHSY1
gene id: 9597:CHSY1
uniprot id: A0A2R9C2N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9597:ADPRS
gene id: 9597:ADPRS
uniprot id: A0A2R9C936
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9597:NUP50
gene id: 9597:NUP50
uniprot id: A0A2R9ATL1
names: Subcellular Location Annotation
messages: nuclear pore complex

9597:SLC27A1
gene id: 9597:SLC27A1
uniprot id: A0A2R9CKC4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:NIPAL3
gene id: 9597:NIPAL3
uniprot id: A0A2R9B3W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9597:TENT5A
gene id: 9597:TENT5A
uniprot id: A0A2R8ZZJ1
names: Similarity
messages: Belongs to the TENT family.

9597:TIMM22
gene id: 9597:TIMM22
uniprot id: A0A2R9B4J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9597:TLCD1
gene id: 9597:TLCD1
uniprot id: A0A2R9B902
names: Subcellular Location Annotation
messages: Membrane

9597:HAO1
gene id: 9597:HAO1
uniprot id: A0A2R8ZF43
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9597:RAB38
gene id: 9597:RAB38
uniprot id: A0A2R9BF11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9597:TM4SF4
gene id: 9597:TM4SF4
uniprot id: A0A2R9C7E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9597:LOC100981957
gene id: 9597:LOC100981957
uniprot id: A0A2R9CJG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:LOC100984043
gene id: 9597:LOC100984043
uniprot id: A0A2R9A954
names: Function
messages: May be involved in transcriptional regulation.

9597:SNRPG
gene id: 9597:SNRPG
uniprot id: A0A2R9AAU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9597:ZNF444
gene id: 9597:ZNF444
uniprot id: A0A2R9BZ75
names: Subcellular Location Annotation
messages: Nucleus

9597:MED11
gene id: 9597:MED11
uniprot id: A0A2R8ZI02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:TMEM135
gene id: 9597:TMEM135
uniprot id: A0A2R8ZH39
uniprot id: A0A2R8ZJR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane

9597:ACOX3
gene id: 9597:ACOX3
uniprot id: A0A2R8ZCT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9597:SSTR1
gene id: 9597:SSTR1
uniprot id: A0A2R8ZDJ5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:COG7
gene id: 9597:COG7
uniprot id: A0A2R9BJ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:PSME2
gene id: 9597:PSME2
uniprot id: A0A2R8ZA22
names: Similarity
messages: Belongs to the PA28 family.

9597:BCAN
gene id: 9597:BCAN
uniprot id: A0A2R9BXM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:GRWD1
gene id: 9597:GRWD1
uniprot id: A0A2R8ZUH4
names: Subcellular Location Annotation
messages: Nucleus

9597:PTDSS1
gene id: 9597:PTDSS1
uniprot id: A0A2R9C088
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:ARMC9
gene id: 9597:ARMC9
uniprot id: A0A2R9CMS4
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.
messages: centriole
messages: cilium
messages: cilium basal body

9597:MCM3
gene id: 9597:MCM3
uniprot id: A0A2R9A466
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9597:MAP1LC3B2
gene id: 9597:MAP1LC3B2
uniprot id: A0A2R8ZA12
names: Similarity
messages: Belongs to the ATG8 family.

9597:IL15
gene id: 9597:IL15
uniprot id: A0A2R9CIQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9597:ZNF12
gene id: 9597:ZNF12
uniprot id: A0A2R9A3E5
names: Function
messages: May be involved in transcriptional regulation.

9597:EPAS1
gene id: 9597:EPAS1
uniprot id: A0A2R9BIT2
names: Subcellular Location Annotation
messages: Nucleus speckle

9597:CPS1
gene id: 9597:CPS1
uniprot id: A0A2R9BH47
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:NSMCE1
gene id: 9597:NSMCE1
uniprot id: A0A2R9CHD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9597:SCGB2A1
gene id: 9597:SCGB2A1
uniprot id: A0A2R9C1P9
names: Subcellular Location Annotation
messages: Secreted

9597:ARG2
gene id: 9597:ARG2
uniprot id: A0A2R9CNG5
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9597:TFAP2C
gene id: 9597:TFAP2C
uniprot id: A0A2R9AQD2
names: Similarity
messages: Belongs to the AP-2 family.

9597:LMBR1L
gene id: 9597:LMBR1L
uniprot id: A0A2R9CHP9
names: Similarity
messages: Belongs to the LIMR family.

9597:SSR1
gene id: 9597:SSR1
uniprot id: A0A2R9AMU5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9597:NELL1
gene id: 9597:NELL1
uniprot id: A0A2R9BHN3
uniprot id: A0A2R9BHP0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CDC25A
gene id: 9597:CDC25A
uniprot id: A0A2R9B0S6
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9597:PCMTD2
gene id: 9597:PCMTD2
uniprot id: A0A2R8ZMW6
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9597:PPM1L
gene id: 9597:PPM1L
uniprot id: A0A2R9CE87
names: Similarity
messages: Belongs to the PP2C family.

9597:TLR10
gene id: 9597:TLR10
uniprot id: A0A2R8ZHQ6
uniprot id: B3Y670
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9597:FAM149A
gene id: 9597:FAM149A
uniprot id: A0A2R9B278
names: Similarity
messages: Belongs to the FAM149 family.

9597:PWP2
gene id: 9597:PWP2
uniprot id: A0A2R9BMW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

9597:LYZL6
gene id: 9597:LYZL6
uniprot id: A0A2R9ALD5
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9597:EPHB1
gene id: 9597:EPHB1
uniprot id: A0A2R8ZM22
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9597:RAD21
gene id: 9597:RAD21
uniprot id: A0A2R8ZFT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9597:EMG1
gene id: 9597:EMG1
uniprot id: A0A2R9AXE4
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9597:TPST1
gene id: 9597:TPST1
uniprot id: A0A2R8Z7U4
uniprot id: A0A2R8Z821
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9597:RANBP17
gene id: 9597:RANBP17
uniprot id: A0A2R9CHP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9597:ING2
gene id: 9597:ING2
uniprot id: A0A2R9CAK7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9597:LOC100971602
gene id: 9597:LOC100971602
uniprot id: A0A2R9AXC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9597:CRBN
gene id: 9597:CRBN
uniprot id: A0A2R9CKP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9597:GHRHR
gene id: 9597:GHRHR
uniprot id: A0A2R9AAT3
names: Subcellular Location Annotation
messages: Membrane

9597:SEMA4F
gene id: 9597:SEMA4F
uniprot id: A0A2R9CL15
uniprot id: A0A2R9CL37
uniprot id: A0A2R9CNB4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ATP6V1E1
gene id: 9597:ATP6V1E1
uniprot id: A0A2R9BJF0
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9597:HYAL2
gene id: 9597:HYAL2
uniprot id: A0A2R9AAT0
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9597:VDAC1
gene id: 9597:VDAC1
uniprot id: A0A2R9BFY0
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

9597:SESN2
gene id: 9597:SESN2
uniprot id: A0A2R9BC26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9597:ZNF441
gene id: 9597:ZNF441
uniprot id: A0A2R9BHM1
names: Function
messages: May be involved in transcriptional regulation.

9597:RNF20
gene id: 9597:RNF20
uniprot id: A0A2R9C5Y6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9597:NHEJ1
gene id: 9597:NHEJ1
uniprot id: A0A2R9CEQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

9597:STAMBPL1
gene id: 9597:STAMBPL1
uniprot id: A0A2R8ZNB1
names: Similarity
messages: Belongs to the peptidase M67C family.

9597:SDHAF3
gene id: 9597:SDHAF3
uniprot id: A0A2R9BID7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9597:GNAT3
gene id: 9597:GNAT3
uniprot id: A0A2R8ZVH6
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9597:TSN
gene id: 9597:TSN
uniprot id: A0A2R9APV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9597:LOC100972374
gene id: 9597:LOC100972374
uniprot id: A0A2R8ZLM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:EIF4E2
gene id: 9597:EIF4E2
uniprot id: A0A2R9B0X3
uniprot id: A0A2R9B2B9
uniprot id: A0A2R9B4S9
uniprot id: A0A2R9B799
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9597:MTHFR
gene id: 9597:MTHFR
uniprot id: A0A2R9BUM3
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

9597:NEMF
gene id: 9597:NEMF
uniprot id: A0A2R9ASD9
names: Similarity
messages: Belongs to the NEMF family.

9597:AURKC
gene id: 9597:AURKC
uniprot id: A0A2R9C9K6
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

9597:HEXB
gene id: 9597:HEXB
uniprot id: A0A2R9CF26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9597:FRK
gene id: 9597:FRK
uniprot id: A0A2R9BRU0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9597:ADH4
gene id: 9597:ADH4
uniprot id: A0A2R9CDG7
uniprot id: A0A2R9CNV9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9597:MAL
gene id: 9597:MAL
uniprot id: A0A2R9BS55
names: Subcellular Location Annotation
messages: Membrane

9597:SERPINB2
gene id: 9597:SERPINB2
uniprot id: A0A2R9BU70
names: Similarity
messages: Belongs to the serpin family.

9597:ZNF205
gene id: 9597:ZNF205
uniprot id: A0A2R9ABJ3
names: Function
messages: May be involved in transcriptional regulation.

9597:KYNU
gene id: 9597:KYNU
uniprot id: A0A2R8ZE77
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:RNF114
gene id: 9597:RNF114
uniprot id: A0A2R9CS64
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
messages: Nucleus

9597:ISX
gene id: 9597:ISX
uniprot id: A0A2R8ZKJ5
names: Subcellular Location Annotation
messages: Nucleus

9597:TRIM36
gene id: 9597:TRIM36
uniprot id: A0A2R9BP33
names: Subcellular Location Annotation
messages: cytoskeleton

9597:HSPB8
gene id: 9597:HSPB8
uniprot id: A0A2R9AWK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9597:SMPX
gene id: 9597:SMPX
uniprot id: A0A2R9A9X5
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

9597:SDC2
gene id: 9597:SDC2
uniprot id: A0A2R9B549
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9597:RBM48
gene id: 9597:RBM48
uniprot id: A0A2R9BU12
names: Function
names: Similarity
names: Subunit
messages: As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: Belongs to the RBM48 family.
messages: Component of the minor spliceosome. Within this complex, interacts with ARMC7 and PRPF8/PRP8.

9597:LIMS2
gene id: 9597:LIMS2
uniprot id: A0A2R9BH15
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9597:OAS1
gene id: 9597:OAS1
uniprot id: B6RC68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9597:FAM3B
gene id: 9597:FAM3B
uniprot id: A0A2R9AGR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9597:ENTPD6
gene id: 9597:ENTPD6
uniprot id: A0A2R9ALI8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9597:NINJ2
gene id: 9597:NINJ2
uniprot id: A0A2R9AZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

9597:DGAT2L6
gene id: 9597:DGAT2L6
uniprot id: A0A2R9AYH5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SKIL
gene id: 9597:SKIL
uniprot id: A0A2R9A8L9
uniprot id: A0A2R9A8M4
names: Similarity
messages: Belongs to the SKI family.

9597:NOC3L
gene id: 9597:NOC3L
uniprot id: A0A2R9CK72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

9597:NDUFA12
gene id: 9597:NDUFA12
uniprot id: A0A2R8ZLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:MOCS1
gene id: 9597:MOCS1
uniprot id: A0A2R9CEX6
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

9597:CWF19L1
gene id: 9597:CWF19L1
uniprot id: A0A2R9ASJ2
names: Similarity
messages: Belongs to the CWF19 family.

9597:TNS4
gene id: 9597:TNS4
uniprot id: A0A2R8ZYL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9597:TMCC2
gene id: 9597:TMCC2
uniprot id: A0A2R9ADG7
names: Similarity
messages: Belongs to the TEX28 family.

9597:CTNNA2
gene id: 9597:CTNNA2
uniprot id: A0A2R9BZX4
uniprot id: A0A2R9C0I6
uniprot id: A0A2R9CA35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9597:SLC39A9
gene id: 9597:SLC39A9
uniprot id: A0A2R9AF04
uniprot id: A0A2R9AJU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: perinuclear region
messages: trans-Golgi network membrane

9597:TRMT61A
gene id: 9597:TRMT61A
uniprot id: A0A2R8ZZL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

9597:PSMG2
gene id: 9597:PSMG2
uniprot id: A0A2R9ACY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

9597:SKA3
gene id: 9597:SKA3
uniprot id: A0A2R9BI31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

9597:SAP130
gene id: 9597:SAP130
uniprot id: A0A2R9BNT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

9597:ZNF449
gene id: 9597:ZNF449
uniprot id: A1YFW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:ETV3
gene id: 9597:ETV3
uniprot id: A0A2R9A6A5
uniprot id: A1YG91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity (By similarity).

9597:APOC3
gene id: 9597:APOC3
uniprot id: A0A2R8ZG19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Secreted

9597:ACSM4
gene id: 9597:ACSM4
uniprot id: A0A2R9AFR0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:ROCK1
gene id: 9597:ROCK1
uniprot id: A0A2R9BZ36
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

9597:IVD
gene id: 9597:IVD
uniprot id: A0A2R9A7H7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9597:LOC100974724
gene id: 9597:LOC100974724
uniprot id: A0A2R8ZBM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TNFRSF10A
gene id: 9597:TNFRSF10A
uniprot id: A0A2R9C3Q3
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

9597:TLR1
gene id: 9597:TLR1
uniprot id: B3Y607
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

9597:LOC100971127
gene id: 9597:LOC100971127
uniprot id: A0A2R9BYI1
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:PLCB3
gene id: 9597:PLCB3
uniprot id: A0A2R9CAD8
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9597:RBM22
gene id: 9597:RBM22
uniprot id: A0A2R9B305
names: Similarity
messages: Belongs to the SLT11 family.

9597:PARK7
gene id: 9597:PARK7
uniprot id: A0A2R9AGT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9597:PRKAA1
gene id: 9597:PRKAA1
uniprot id: A0A2R9B7U6
uniprot id: A0A2R9BBM3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9597:LOC106635432
gene id: 9597:LOC106635432
uniprot id: A0A2R9C9M6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9597:HIGD1B
gene id: 9597:HIGD1B
uniprot id: A0A2R9BGG4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9597:LOC103783978
gene id: 9597:LOC103783978
uniprot id: A0A2R9CPL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:LOC100972994
gene id: 9597:LOC100972994
uniprot id: A0A2R9CFN7
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Lysosome membrane

9597:GFAP
gene id: 9597:GFAP
uniprot id: A0A2R9CBF8
names: Similarity
messages: Belongs to the intermediate filament family.

9597:ADCY7
gene id: 9597:ADCY7
uniprot id: A0A2R8ZW57
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9597:CLPP
gene id: 9597:CLPP
uniprot id: A0A2R9CDX0
names: Similarity
messages: Belongs to the peptidase S14 family.

9597:COPA
gene id: 9597:COPA
uniprot id: A0A2R9A2F0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9597:NDP
gene id: 9597:NDP
uniprot id: A0A2R9A195
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:CDC42EP3
gene id: 9597:CDC42EP3
uniprot id: A0A2R8Z776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9597:APEH
gene id: 9597:APEH
uniprot id: A0A2R9C4F1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.

9597:HINT1
gene id: 9597:HINT1
uniprot id: A0A2R9BUQ1
names: Similarity
messages: Belongs to the HINT family.

9597:MAPK7
gene id: 9597:MAPK7
uniprot id: A0A2R9BV16
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9597:IK
gene id: 9597:IK
uniprot id: A0A2R8ZGY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9597:IRF6
gene id: 9597:IRF6
uniprot id: A0A2R9AW22
names: Subcellular Location Annotation
messages: Nucleus

9597:OOEP
gene id: 9597:OOEP
uniprot id: A0A2R9BPN2
names: Similarity
messages: Belongs to the KHDC1 family.

9597:CTSA
gene id: 9597:CTSA
uniprot id: A0A2R8ZSD6
uniprot id: A0A2R8ZV77
names: Similarity
messages: Belongs to the peptidase S10 family.

9597:IDH1
gene id: 9597:IDH1
uniprot id: A0A2R9BW49
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Homodimer.

9597:CALCRL
gene id: 9597:CALCRL
uniprot id: A0A2R9BXQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9597:XPR1
gene id: 9597:XPR1
uniprot id: A0A2R8ZLI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

9597:FH
gene id: 9597:FH
uniprot id: A0A2R9A8K1
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9597:TMEM94
gene id: 9597:TMEM94
uniprot id: A0A2R9CNB1
names: Subcellular Location Annotation
messages: Membrane

9597:NFYB
gene id: 9597:NFYB
uniprot id: A0A2R9C725
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9597:ASB10
gene id: 9597:ASB10
uniprot id: A0A2R9C4I6
uniprot id: A0A2R9C4X4
uniprot id: A0A2R9C7H8
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:ACSS3
gene id: 9597:ACSS3
uniprot id: A0A2R9C396
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:ACER2
gene id: 9597:ACER2
uniprot id: A0A2R9BD30
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:BRS3
gene id: 9597:BRS3
uniprot id: A0A2R9AGX3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9597:CHMP4A
gene id: 9597:CHMP4A
uniprot id: A0A2R9CC56
names: Similarity
messages: Belongs to the SNF7 family.

9597:SGK3
gene id: 9597:SGK3
uniprot id: A0A2R9BP29
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9597:PTPN2
gene id: 9597:PTPN2
uniprot id: A0A2R9BT42
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9597:RAP2A
gene id: 9597:RAP2A
uniprot id: A0A2R8ZLW6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9597:ELMO2
gene id: 9597:ELMO2
uniprot id: A0A2R9A3F4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9597:ATP5MC1
gene id: 9597:ATP5MC1
uniprot id: A0A2R9C6Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9597:RARG
gene id: 9597:RARG
uniprot id: A0A2R9A872
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9597:FAM210A
gene id: 9597:FAM210A
uniprot id: A0A2R9BGK8
names: Similarity
messages: Belongs to the FAM210 family.

9597:RCAN2
gene id: 9597:RCAN2
uniprot id: A0A2R9A2S3
uniprot id: A0A2R9A643
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9597:CNNM3
gene id: 9597:CNNM3
uniprot id: A0A2R9CGX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Metal transporter.

9597:DNAJC24
gene id: 9597:DNAJC24
uniprot id: A0A2R9ANH5
names: Similarity
messages: Belongs to the DPH4 family.

9597:JAGN1
gene id: 9597:JAGN1
uniprot id: A0A2R9BJF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:RFT1
gene id: 9597:RFT1
uniprot id: A0A2R9B8R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

9597:RGS2
gene id: 9597:RGS2
uniprot id: A0A2R9BEH1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: nucleolus

9597:LCORL
gene id: 9597:LCORL
uniprot id: A0A2R9BTZ1
names: Subcellular Location Annotation
messages: Nucleus

9597:ALG11
gene id: 9597:ALG11
uniprot id: A0A2R9B5J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

9597:PRPF4
gene id: 9597:PRPF4
uniprot id: A0A2R9CB33
names: Subcellular Location Annotation
messages: Nucleus speckle

9597:PADI4
gene id: 9597:PADI4
uniprot id: A0A2R9AGC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9597:CYFIP1
gene id: 9597:CYFIP1
uniprot id: A0A2R8ZVG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

9597:DSCC1
gene id: 9597:DSCC1
uniprot id: A0A2R8ZGV0
names: Similarity
messages: Belongs to the DCC1 family.

9597:S100A6
gene id: 9597:S100A6
uniprot id: A0A2R9A6E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
messages: Nucleus envelope

9597:IL10
gene id: 9597:IL10
uniprot id: A0A2R8ZE59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9597:ANXA3
gene id: 9597:ANXA3
uniprot id: A0A2R9AXV0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9597:ATP1B4
gene id: 9597:ATP1B4
uniprot id: A0A2R9BY14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9597:CNTFR
gene id: 9597:CNTFR
uniprot id: A0A2R9C7G4
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9597:GABRA2
gene id: 9597:GABRA2
uniprot id: A0A2R8ZZ28
uniprot id: A0A2R9A081
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9597:HSD17B11
gene id: 9597:HSD17B11
uniprot id: A0A2R8ZH80
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:CCL5
gene id: 9597:CCL5
uniprot id: A0A2R9CSX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:OGT
gene id: 9597:OGT
uniprot id: A0A2R9AEH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9597:VPS45
gene id: 9597:VPS45
uniprot id: A0A2R9BUS7
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9597:KBTBD8
gene id: 9597:KBTBD8
uniprot id: A0A2R9C7L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

9597:GPR3
gene id: 9597:GPR3
uniprot id: A0A2R8ZGH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:ATG4A
gene id: 9597:ATG4A
uniprot id: A0A2R8ZNT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9597:RFTN1
gene id: 9597:RFTN1
uniprot id: A0A2R9CJE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9597:IRF9
gene id: 9597:IRF9
uniprot id: A0A2R8ZDH2
names: Subcellular Location Annotation
messages: Nucleus

9597:SEPHS1
gene id: 9597:SEPHS1
uniprot id: A0A2R9BTM4
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9597:LOC100973061
gene id: 9597:LOC100973061
uniprot id: A0A2R9CIL5
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9597:SNX17
gene id: 9597:SNX17
uniprot id: A0A2R9CN12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9597:ZNF382
gene id: 9597:ZNF382
uniprot id: A0A2R9ASL8
names: Function
messages: May be involved in transcriptional regulation.

9597:TMED1
gene id: 9597:TMED1
uniprot id: A0A2R9AJK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9597:MAPK4
gene id: 9597:MAPK4
uniprot id: A0A2R8ZAT0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9597:HSCB
gene id: 9597:HSCB
uniprot id: A0A2R9ALN2
names: Similarity
messages: Belongs to the HscB family.

9597:LOC100983379
gene id: 9597:LOC100983379
uniprot id: A0A2R8Z6H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:AGPAT2
gene id: 9597:AGPAT2
uniprot id: A0A2R9BV35
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9597:TMEM144
gene id: 9597:TMEM144
uniprot id: A0A2R9AD68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

9597:STK10
gene id: 9597:STK10
uniprot id: A0A2R8ZGP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cell membrane

9597:UPK1B
gene id: 9597:UPK1B
uniprot id: A0A2R9BNL6
names: Subcellular Location Annotation
messages: Membrane

9597:HTN1
gene id: 9597:HTN1
uniprot id: A0A2R8ZQG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Secreted

9597:GADD45B
gene id: 9597:GADD45B
uniprot id: A0A2R9CMK8
names: Similarity
messages: Belongs to the GADD45 family.

9597:NPY1R
gene id: 9597:NPY1R
uniprot id: A0A2R9CMK6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:Papa-A
gene id: 9597:Papa-A
uniprot id: Q30900
names: Similarity
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

9597:BSX
gene id: 9597:BSX
uniprot id: A0A2R9C627
names: Subcellular Location Annotation
messages: Nucleus

9597:AMD1
gene id: 9597:AMD1
uniprot id: A0A2R9CP40
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9597:NR0B2
gene id: 9597:NR0B2
uniprot id: A0A2R9BTU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9597:ACTL10
gene id: 9597:ACTL10
uniprot id: A0A2R8ZWT6
names: Similarity
messages: Belongs to the actin family.

9597:LOC100974904
gene id: 9597:LOC100974904
uniprot id: A0A2R8ZDN1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:TFB1M
gene id: 9597:TFB1M
uniprot id: A0A2R9ADI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

9597:SDC4
gene id: 9597:SDC4
uniprot id: A0A2R8ZSI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9597:ACTL6A
gene id: 9597:ACTL6A
uniprot id: A0A2R9AKF6
names: Similarity
messages: Belongs to the actin family.

9597:EEF1AKMT1
gene id: 9597:EEF1AKMT1
uniprot id: A0A2R9C8B4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

9597:PRPSAP1
gene id: 9597:PRPSAP1
uniprot id: A0A2R9ANY8
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9597:UBA2
gene id: 9597:UBA2
uniprot id: A0A2R9AE16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Nucleus
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

9597:LOC100987164
gene id: 9597:LOC100987164
uniprot id: A0A2R9BJ63
names: Similarity
messages: Belongs to the SKP1 family.

9597:NTN4
gene id: 9597:NTN4
uniprot id: A0A2R9A3J5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TBPL1
gene id: 9597:TBPL1
uniprot id: A0A2R8ZHH2
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9597:ITGAV
gene id: 9597:ITGAV
uniprot id: A0A2R9B7W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:MGME1
gene id: 9597:MGME1
uniprot id: A0A2R9A2R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGME1 family.
messages: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.
messages: Mitochondrion

9597:LOC100987460
gene id: 9597:LOC100987460
uniprot id: A0A2R8ZCN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SASS6
gene id: 9597:SASS6
uniprot id: A0A2R9ALG5
names: Subcellular Location Annotation
messages: centrosome

9597:ZNF667
gene id: 9597:ZNF667
uniprot id: A0A2R9C868
names: Function
messages: May be involved in transcriptional regulation.

9597:HOXA7
gene id: 9597:HOXA7
uniprot id: A0A2R9AYE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:FOXJ2
gene id: 9597:FOXJ2
uniprot id: A0A2R9C3N6
names: Subcellular Location Annotation
messages: Nucleus

9597:ERLEC1
gene id: 9597:ERLEC1
uniprot id: A0A2R9C749
uniprot id: A0A2R9C9X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

9597:PARPBP
gene id: 9597:PARPBP
uniprot id: A0A2R9BME9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9597:AK5
gene id: 9597:AK5
uniprot id: A0A2R9AW32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

9597:WNT1
gene id: 9597:WNT1
uniprot id: A0A2R8ZPY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:MRPS18B
gene id: 9597:MRPS18B
uniprot id: A0A2R9BVF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

9597:DEFB114
gene id: 9597:DEFB114
uniprot id: A0A2R9ABV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9597:OTOP3
gene id: 9597:OTOP3
uniprot id: A0A2R9AFC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9597:CEBPZ
gene id: 9597:CEBPZ
uniprot id: A0A2R9CR99
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9597:GDPD2
gene id: 9597:GDPD2
uniprot id: A0A2R8ZGG7
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9597:NLRP14
gene id: 9597:NLRP14
uniprot id: A0A2R9C0B5
names: Similarity
messages: Belongs to the NLRP family.

9597:LOC100987260
gene id: 9597:LOC100987260
uniprot id: A0A2R9ACG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9597:HK2
gene id: 9597:HK2
uniprot id: A0A2R9BNP9
names: Similarity
messages: Belongs to the hexokinase family.

9597:GPT2
gene id: 9597:GPT2
uniprot id: A0A2R9BCX8
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9597:SNAPIN
gene id: 9597:SNAPIN
uniprot id: A0A2R9BL68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9597:GTF2A2
gene id: 9597:GTF2A2
uniprot id: A0A2R9BP38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9597:ABI1
gene id: 9597:ABI1
uniprot id: A0A2R9BPX0
uniprot id: A0A2R9BPY7
uniprot id: A0A2R9BQM8
uniprot id: A0A2R9BTE7
uniprot id: A0A2R9BYZ2
uniprot id: A0A2R9BYZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9597:SLC28A3
gene id: 9597:SLC28A3
uniprot id: A0A2R9BPV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9597:AVPR1B
gene id: 9597:AVPR1B
uniprot id: A0A2R9BIK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9597:TM4SF18
gene id: 9597:TM4SF18
uniprot id: A0A2R9BTJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9597:MRPL50
gene id: 9597:MRPL50
uniprot id: A0A2R8ZV16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9597:ALKBH6
gene id: 9597:ALKBH6
uniprot id: A0A2R9BCU9
uniprot id: A0A2R9BGS0
names: Similarity
messages: Belongs to the alkB family.

9597:ARF4
gene id: 9597:ARF4
uniprot id: A0A2R9BFR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9597:RNGTT
gene id: 9597:RNGTT
uniprot id: A0A2R8ZMZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

9597:SERPINB1
gene id: 9597:SERPINB1
uniprot id: A0A2R9CF34
names: Similarity
messages: Belongs to the serpin family.

9597:PER1
gene id: 9597:PER1
uniprot id: A0A2R9C274
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:ELAC2
gene id: 9597:ELAC2
uniprot id: A0A2R8ZGH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Z family.
messages: mitochondrion nucleoid

9597:LSM6
gene id: 9597:LSM6
uniprot id: A0A2R9BKB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9597:CNIH3
gene id: 9597:CNIH3
uniprot id: A0A2R9CBU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9597:ARL6
gene id: 9597:ARL6
uniprot id: A0A2R9CMQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9597:PCOLCE2
gene id: 9597:PCOLCE2
uniprot id: A0A2R9AA73
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:UBE2G2
gene id: 9597:UBE2G2
uniprot id: A0A2R9AH46
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:GPM6A
gene id: 9597:GPM6A
uniprot id: A0A2R9CEY0
uniprot id: A0A2R9CF51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9597:TUT1
gene id: 9597:TUT1
uniprot id: A0A2R9BGB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Nucleus speckle
messages: nucleolus

9597:BMP10
gene id: 9597:BMP10
uniprot id: A0A2R9CI72
names: Similarity
messages: Belongs to the TGF-beta family.

9597:PEX16
gene id: 9597:PEX16
uniprot id: A0A2R9CBX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

9597:GRHPR
gene id: 9597:GRHPR
uniprot id: A0A2R9BIX8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9597:SLC25A53
gene id: 9597:SLC25A53
uniprot id: A0A2R8ZKK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:LOC100982531
gene id: 9597:LOC100982531
uniprot id: A0A2R9A4U4
names: Subcellular Location Annotation
messages: Membrane

9597:POMT1
gene id: 9597:POMT1
uniprot id: A0A2R8ZUX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9597:GDPD1
gene id: 9597:GDPD1
uniprot id: A0A2R9AYR7
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9597:AXL
gene id: 9597:AXL
uniprot id: A0A2R9BJ67
uniprot id: A0A2R9BLV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

9597:BZW1
gene id: 9597:BZW1
uniprot id: A0A2R9A2I6
names: Similarity
messages: Belongs to the BZW family.

9597:FGF14
gene id: 9597:FGF14
uniprot id: A0A2R9BRI2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:GALK1
gene id: 9597:GALK1
uniprot id: A0A2R8ZVN8
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9597:CRYAB
gene id: 9597:CRYAB
uniprot id: A0A2R9CGA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9597:IFI27
gene id: 9597:IFI27
uniprot id: A0A2R9AQR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9597:ACOX2
gene id: 9597:ACOX2
uniprot id: A0A2R9A996
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9597:TADA3
gene id: 9597:TADA3
uniprot id: A0A2R9CDX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

9597:METTL4
gene id: 9597:METTL4
uniprot id: A0A2R9ACH1
names: Similarity
messages: Belongs to the MT-A70-like family.

9597:GGH
gene id: 9597:GGH
uniprot id: A0A2R9BLC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9597:FAM98B
gene id: 9597:FAM98B
uniprot id: A0A2R9BM14
names: Similarity
messages: Belongs to the FAM98 family.

9597:FNTB
gene id: 9597:FNTB
uniprot id: A0A2R9AQT6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
messages: Heterodimer of FNTA and FNTB.

9597:LOC100985779
gene id: 9597:LOC100985779
uniprot id: A0A2R8ZPM7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:S100PBP
gene id: 9597:S100PBP
uniprot id: A0A2R9ABU9
names: Subcellular Location Annotation
messages: Nucleus

9597:BCL2A1
gene id: 9597:BCL2A1
uniprot id: A0A2R8ZJX9
names: Similarity
messages: Belongs to the Bcl-2 family.

9597:XRCC4
gene id: 9597:XRCC4
uniprot id: A0A2R9BZA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

9597:CCL15
gene id: 9597:CCL15
uniprot id: A0A2R9B897
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:SZRD1
gene id: 9597:SZRD1
uniprot id: A0A2R9AJF1
uniprot id: A0A2R9ARK1
names: Similarity
messages: Belongs to the SZRD1 family.

9597:TMEM178B
gene id: 9597:TMEM178B
uniprot id: A0A2R8Z743
names: Similarity
messages: Belongs to the TMEM178 family.

9597:CCR1
gene id: 9597:CCR1
uniprot id: A0A2R8ZPK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9597:MINDY2
gene id: 9597:MINDY2
uniprot id: A0A2R9C0C7
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9597:VHL
gene id: 9597:VHL
uniprot id: A0A2R9B5S8
uniprot id: A0A2R9BCX6
names: Similarity
messages: Belongs to the VHL family.

9597:WDR55
gene id: 9597:WDR55
uniprot id: A0A2R9CDN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

9597:PSMD13
gene id: 9597:PSMD13
uniprot id: A0A2R9CM00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9597:KCNAB3
gene id: 9597:KCNAB3
uniprot id: A0A2R8ZH61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

9597:CCDC103
gene id: 9597:CCDC103
uniprot id: A0A2R8ZE44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9597:SLC25A13
gene id: 9597:SLC25A13
uniprot id: A0A2R9B4H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:CXCL16
gene id: 9597:CXCL16
uniprot id: A0A2R8ZR36
names: Subcellular Location Annotation
messages: Membrane

9597:LAMP5
gene id: 9597:LAMP5
uniprot id: A0A2R8ZH08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Membrane

9597:TAS2R10
gene id: 9597:TAS2R10
uniprot id: Q646D7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:CORO2A
gene id: 9597:CORO2A
uniprot id: A0A2R9C3A8
names: Similarity
messages: Belongs to the WD repeat coronin family.

9597:SMPD2
gene id: 9597:SMPD2
uniprot id: A0A2R9ANF2
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9597:LOC100967790
gene id: 9597:LOC100967790
uniprot id: A0A2R9AJ20
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:CENPJ
gene id: 9597:CENPJ
uniprot id: A0A2R9AAS2
names: Similarity
messages: Belongs to the TCP10 family.

9597:CREG1
gene id: 9597:CREG1
uniprot id: A0A2R9AZX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9597:FUNDC1
gene id: 9597:FUNDC1
uniprot id: A0A2R9ACQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9597:MTFR2
gene id: 9597:MTFR2
uniprot id: A0A2R9C2G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9597:REEP4
gene id: 9597:REEP4
uniprot id: A0A2R9BBT2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:SEMA3E
gene id: 9597:SEMA3E
uniprot id: A0A2R9A876
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:BCCIP
gene id: 9597:BCCIP
uniprot id: A0A2R8ZMB1
uniprot id: A0A2R8ZQI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

9597:CCL22
gene id: 9597:CCL22
uniprot id: A0A2R9C4E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:ELOVL6
gene id: 9597:ELOVL6
uniprot id: A0A2R9AUT1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

9597:EXTL2
gene id: 9597:EXTL2
uniprot id: A0A2R9BBV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:LOC100980365
gene id: 9597:LOC100980365
uniprot id: A0A2R8ZDY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:BCLAF3
gene id: 9597:BCLAF3
uniprot id: A0A2R9C7Q7
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9597:RBKS
gene id: 9597:RBKS
uniprot id: A0A2R9AXG3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9597:TAF11
gene id: 9597:TAF11
uniprot id: A0A2R9C8S6
uniprot id: A0A2R9CGM7
names: Similarity
messages: Belongs to the TAF11 family.

9597:UTP11
gene id: 9597:UTP11
uniprot id: A0A2R9A9M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9597:LOC103784619
gene id: 9597:LOC103784619
uniprot id: A0A2R9AL82
names: Function
messages: May be involved in transcriptional regulation.

9597:MTNR1B
gene id: 9597:MTNR1B
uniprot id: A0A2R9ADD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9597:ZNF112
gene id: 9597:ZNF112
uniprot id: A0A2R9C319
uniprot id: A0A2R9CA15
names: Function
messages: May be involved in transcriptional regulation.

9597:AKAP12
gene id: 9597:AKAP12
uniprot id: A0A2R8ZT05
uniprot id: A0A2R8ZYS7
names: Subcellular Location Annotation
messages: Membrane

9597:GEM
gene id: 9597:GEM
uniprot id: A0A2R8ZMM8
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9597:MRPL16
gene id: 9597:MRPL16
uniprot id: A0A2R9BS01
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9597:MOGAT3
gene id: 9597:MOGAT3
uniprot id: A0A2R9CLU9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TEC
gene id: 9597:TEC
uniprot id: A0A2R9AFD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9597:LOC100976323
gene id: 9597:LOC100976323
uniprot id: A0A2R8ZGF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CAPN12
gene id: 9597:CAPN12
uniprot id: A0A2R9BTR5
names: Similarity
messages: Belongs to the peptidase C2 family.

9597:PLSCR2
gene id: 9597:PLSCR2
uniprot id: A0A2R8ZPV5
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9597:AMPD1
gene id: 9597:AMPD1
uniprot id: A0A2R9BAW9
uniprot id: A0A2R9BD70
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9597:ROMO1
gene id: 9597:ROMO1
uniprot id: A0A2R8ZQZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9597:NQO1
gene id: 9597:NQO1
uniprot id: A0A2R9ATE6
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9597:TLL2
gene id: 9597:TLL2
uniprot id: A0A2R9C077
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:DPH2
gene id: 9597:DPH2
uniprot id: A0A2R9BW78
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

9597:ALKAL1
gene id: 9597:ALKAL1
uniprot id: A0A2R9C248
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9597:CSRNP3
gene id: 9597:CSRNP3
uniprot id: A0A2R9B103
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9597:MAP3K12
gene id: 9597:MAP3K12
uniprot id: A0A2R9C1I8
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: May be an activator of the JNK/SAPK pathway.

9597:MMP2
gene id: 9597:MMP2
uniprot id: A0A2R9BYR5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

9597:POSTN
gene id: 9597:POSTN
uniprot id: A0A2R9ABE0
uniprot id: A0A2R9ABE4
uniprot id: A0A2R9ABW4
uniprot id: A0A2R9ABY3
names: Subcellular Location Annotation
messages: extracellular matrix

9597:EXOSC2
gene id: 9597:EXOSC2
uniprot id: A0A2R9B0Y2
uniprot id: A0A2R9B7H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9597:ESYT3
gene id: 9597:ESYT3
uniprot id: A0A2R8ZI25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:CFAP91
gene id: 9597:CFAP91
uniprot id: A0A2R9A165
names: Similarity
messages: Belongs to the CFAP91 family.

9597:IL17F
gene id: 9597:IL17F
uniprot id: A0A2R9BY33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9597:FMO5
gene id: 9597:FMO5
uniprot id: A0A2R9AK06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9597:ZNF135
gene id: 9597:ZNF135
uniprot id: A0A2R8Z708
uniprot id: A0A2R8ZAS0
uniprot id: A0A2R8ZD90
names: Function
messages: May be involved in transcriptional regulation.

9597:SLC27A5
gene id: 9597:SLC27A5
uniprot id: A0A2R9C256
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:LOC100988821
gene id: 9597:LOC100988821
uniprot id: A0A2R8ZH37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SNX5
gene id: 9597:SNX5
uniprot id: A0A2R8ZIM8
uniprot id: A0A2R8ZL06
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9597:LOC100993580
gene id: 9597:LOC100993580
uniprot id: A0A2R9A1F7
names: Function
messages: May be involved in transcriptional regulation.

9597:MAP3K13
gene id: 9597:MAP3K13
uniprot id: A0A2R9AUE9
names: Function
names: Similarity
messages: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9597:BID
gene id: 9597:BID
uniprot id: A0A2R9A786
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.
messages: Induces caspases and apoptosis. Counters the protective effect of BCL2.
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:SNRNP200
gene id: 9597:SNRNP200
uniprot id: A0A2R9C7E7
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9597:RPL23A
gene id: 9597:RPL23A
uniprot id: A0A2R9A5I1
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9597:NGB
gene id: 9597:NGB
uniprot id: A0A2R9C3L3
names: Similarity
messages: Belongs to the globin family.

9597:DDO
gene id: 9597:DDO
uniprot id: A0A2R9B5I8
uniprot id: A0A2R9B716
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9597:FAM114A1
gene id: 9597:FAM114A1
uniprot id: A0A2R9BYV1
names: Similarity
messages: Belongs to the FAM114 family.

9597:PRPF4B
gene id: 9597:PRPF4B
uniprot id: A0A2R9BYC3
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

9597:AKR1E2
gene id: 9597:AKR1E2
uniprot id: A0A2R9C2D6
uniprot id: A0A2R9C2E4
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9597:CFLAR
gene id: 9597:CFLAR
uniprot id: A0A2R8ZTA9
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:HSD17B13
gene id: 9597:HSD17B13
uniprot id: A0A2R9CFD9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:LOC100992022
gene id: 9597:LOC100992022
uniprot id: A0A2R9B884
names: Function
messages: May be involved in transcriptional regulation.

9597:SPIN1
gene id: 9597:SPIN1
uniprot id: A0A2R9A2A6
names: Similarity
messages: Belongs to the SPIN/STSY family.

9597:SLC6A9
gene id: 9597:SLC6A9
uniprot id: A0A2R9CHG2
uniprot id: A0A2R9CR51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

9597:GPR15
gene id: 9597:GPR15
uniprot id: A0A2R8ZKQ7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:ELF2
gene id: 9597:ELF2
uniprot id: A0A2R8ZG81
uniprot id: A0A2R8ZGN5
uniprot id: A0A2R8ZGP0
uniprot id: A0A2R8ZML2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:CEPT1
gene id: 9597:CEPT1
uniprot id: A0A2R9CGQ3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9597:LOC100981066
gene id: 9597:LOC100981066
uniprot id: A0A2R8Z963
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CDCA2
gene id: 9597:CDCA2
uniprot id: A0A2R9ARS7
names: Subcellular Location Annotation
messages: Nucleus

9597:MTHFD1
gene id: 9597:MTHFD1
uniprot id: A0A2R8ZEG2
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9597:ORMDL1
gene id: 9597:ORMDL1
uniprot id: A0A2R9C6X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9597:LOC100994024
gene id: 9597:LOC100994024
uniprot id: A0A2R8ZHV4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:ORC6
gene id: 9597:ORC6
uniprot id: A0A2R9BQP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9597:CTSC
gene id: 9597:CTSC
uniprot id: A0A2R9BWH9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9597:RNASET2
gene id: 9597:RNASET2
uniprot id: A0A2R9AMM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Lysosome lumen

9597:AK6
gene id: 9597:AK6
uniprot id: A0A2R9CGZ2
uniprot id: A0A2R9CJQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9597:LYRM2
gene id: 9597:LYRM2
uniprot id: A0A2R9BG06
names: Similarity
messages: Belongs to the complex I LYR family.

9597:ITGA1
gene id: 9597:ITGA1
uniprot id: A0A2R9BDD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:UGT8
gene id: 9597:UGT8
uniprot id: A0A2R8ZEX4
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9597:CLGN
gene id: 9597:CLGN
uniprot id: A0A2R9BZR0
names: Similarity
messages: Belongs to the calreticulin family.

9597:TFE3
gene id: 9597:TFE3
uniprot id: A0A2R9A329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9597:LOC100980404
gene id: 9597:LOC100980404
uniprot id: A0A2R9C518
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9597:STARD3NL
gene id: 9597:STARD3NL
uniprot id: A0A2R9BSN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Membrane

9597:CRYAA
gene id: 9597:CRYAA
uniprot id: A0A2R9AZW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9597:FUT8
gene id: 9597:FUT8
uniprot id: A0A2R8ZTU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9597:CHST3
gene id: 9597:CHST3
uniprot id: A0A2R9C0K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9597:EEIG2
gene id: 9597:EEIG2
uniprot id: A0A2R9BI51
names: Similarity
messages: Belongs to the EEIG family.

9597:ZNF470
gene id: 9597:ZNF470
uniprot id: A0A2R9C2R2
names: Function
messages: May be involved in transcriptional regulation.

9597:DCTPP1
gene id: 9597:DCTPP1
uniprot id: A0A2R9B350
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9597:ZPBP
gene id: 9597:ZPBP
uniprot id: A0A2R9AF12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted
messages: acrosome

9597:FAM32A
gene id: 9597:FAM32A
uniprot id: A0A2R8ZRV6
names: Similarity
messages: Belongs to the FAM32 family.

9597:PARP3
gene id: 9597:PARP3
uniprot id: A0A2R9C2I5
uniprot id: A0A2R9C302
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9597:REC8
gene id: 9597:REC8
uniprot id: A0A2R9AFN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9597:RPS6KA5
gene id: 9597:RPS6KA5
uniprot id: A0A2R9BP98
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9597:SLC25A32
gene id: 9597:SLC25A32
uniprot id: A0A2R9C2T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:HEATR1
gene id: 9597:HEATR1
uniprot id: A0A2R9BJX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9597:CDK20
gene id: 9597:CDK20
uniprot id: A0A2R9BAB7
uniprot id: A0A2R9BBN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: cilium

9597:BEX4
gene id: 9597:BEX4
uniprot id: A0A2R8Z8F7
names: Similarity
messages: Belongs to the BEX family.

9597:ATP6V1H
gene id: 9597:ATP6V1H
uniprot id: A0A2R9BM13
uniprot id: A0A2R9BQN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9597:TMEM216
gene id: 9597:TMEM216
uniprot id: A0A2R8ZFR4
names: Subcellular Location Annotation
messages: Membrane

9597:CYP1A1
gene id: 9597:CYP1A1
uniprot id: A0A2R9B5W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9597:SET
gene id: 9597:SET
uniprot id: A0A2R9A757
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9597:C22H22orf39
gene id: 9597:C22H22orf39
uniprot id: A0A2R9AJ26
uniprot id: A0A2R9AR96
names: Similarity
messages: Belongs to the UPF0545 family.

9597:VPS37A
gene id: 9597:VPS37A
uniprot id: A0A2R9B4U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9597:NDUFV2
gene id: 9597:NDUFV2
uniprot id: A0A2R9ASJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9597:RPL27A
gene id: 9597:RPL27A
uniprot id: A0A2R9A3H5
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9597:PUS1
gene id: 9597:PUS1
uniprot id: A0A2R9C3S2
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9597:C7H7orf25
gene id: 9597:C7H7orf25
uniprot id: A0A2R9C777
names: Similarity
messages: Belongs to the UPF0415 family.

9597:MRFAP1L1
gene id: 9597:MRFAP1L1
uniprot id: A0A2R8ZFY6
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9597:LOC100989841
gene id: 9597:LOC100989841
uniprot id: A0A2R8ZKC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:DVL3
gene id: 9597:DVL3
uniprot id: A0A2R9C8L5
names: Similarity
messages: Belongs to the DSH family.

9597:PPARG
gene id: 9597:PPARG
uniprot id: A0A2R9A3D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

9597:SCGB1D2
gene id: 9597:SCGB1D2
uniprot id: A0A2R8ZCD0
names: Subcellular Location Annotation
messages: Secreted

9597:KRT15
gene id: 9597:KRT15
uniprot id: A0A2R9C995
names: Similarity
messages: Belongs to the intermediate filament family.

9597:TOM1L2
gene id: 9597:TOM1L2
uniprot id: A0A2R8ZNF3
uniprot id: A0A2R8ZRE5
names: Similarity
messages: Belongs to the TOM1 family.

9597:ZNF551
gene id: 9597:ZNF551
uniprot id: A0A2R9AIX6
names: Function
messages: May be involved in transcriptional regulation.

9597:ERCC4
gene id: 9597:ERCC4
uniprot id: A0A2R9BAH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

9597:HEXIM2
gene id: 9597:HEXIM2
uniprot id: A0A2R8ZAX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9597:THEMIS2
gene id: 9597:THEMIS2
uniprot id: A0A2R9AF64
names: Similarity
messages: Belongs to the themis family.

9597:RPS11
gene id: 9597:RPS11
uniprot id: A0A2R9BSU4
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9597:LIAS
gene id: 9597:LIAS
uniprot id: A0A2R9C0M6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9597:LOXL1
gene id: 9597:LOXL1
uniprot id: A0A2R9AG59
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9597:DDIT4
gene id: 9597:DDIT4
uniprot id: A0A2R8ZU89
names: Similarity
messages: Belongs to the DDIT4 family.

9597:GATC
gene id: 9597:GATC
uniprot id: A0A2R9A3N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9597:HCST
gene id: 9597:HCST
uniprot id: A0A2R9B2P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAP10 family.
messages: Membrane

9597:RNASE12
gene id: 9597:RNASE12
uniprot id: A0A2R9AWY8
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9597:MDM2
gene id: 9597:MDM2
uniprot id: A0A2R9AQ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9597:TIMM10B
gene id: 9597:TIMM10B
uniprot id: A0A2R9BXW4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9597:LOC100978488
gene id: 9597:LOC100978488
uniprot id: A0A2R8ZN32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:AMFR
gene id: 9597:AMFR
uniprot id: A0A2R9CF69
names: Subcellular Location Annotation
messages: Membrane

9597:NAP1L4
gene id: 9597:NAP1L4
uniprot id: A0A2R9ALN5
uniprot id: A0A2R9ALP1
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9597:CXCR2
gene id: 9597:CXCR2
uniprot id: A0A2R8ZGE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:MAT2A
gene id: 9597:MAT2A
uniprot id: A0A2R9C4C8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9597:LOC100988443
gene id: 9597:LOC100988443
uniprot id: A0A2R9BB48
names: Function
messages: May be involved in transcriptional regulation.

9597:CNTNAP5
gene id: 9597:CNTNAP5
uniprot id: A0A2R9AJA0
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SRPRA
gene id: 9597:SRPRA
uniprot id: A0A2R9AEJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:SPDL1
gene id: 9597:SPDL1
uniprot id: A0A2R9BEM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

9597:TMOD1
gene id: 9597:TMOD1
uniprot id: A0A2R9A154
names: Subcellular Location Annotation
messages: cytoskeleton

9597:DNAAF8
gene id: 9597:DNAAF8
uniprot id: A0A2R9C6N9
names: Function
names: Subcellular Location Annotation
messages: Dynein axonemal particle
messages: In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.

9597:FLCN
gene id: 9597:FLCN
uniprot id: A0A2R9CNN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9597:IL4I1
gene id: 9597:IL4I1
uniprot id: A0A2R9BZW6
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9597:CMAS
gene id: 9597:CMAS
uniprot id: A0A2R9BYY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

9597:TMED7
gene id: 9597:TMED7
uniprot id: A0A2R9A1N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9597:SMU1
gene id: 9597:SMU1
uniprot id: A0A2R9AQP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9597:ISM2
gene id: 9597:ISM2
uniprot id: A0A2R9AX37
names: Similarity
messages: Belongs to the isthmin family.

9597:OTUB2
gene id: 9597:OTUB2
uniprot id: A0A2R9A3M9
names: Similarity
messages: Belongs to the peptidase C65 family.

9597:AK1
gene id: 9597:AK1
uniprot id: A0A2R9AYN7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

9597:NCBP2
gene id: 9597:NCBP2
uniprot id: A0A2R9BE18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9597:SPECC1L
gene id: 9597:SPECC1L
uniprot id: A0A2R9AC63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9597:TMEM17
gene id: 9597:TMEM17
uniprot id: A0A2R8ZC99
names: Subcellular Location Annotation
messages: Membrane

9597:TNFSF13
gene id: 9597:TNFSF13
uniprot id: A0A2R8ZPT3
uniprot id: A0A2R8ZVN2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9597:BLMH
gene id: 9597:BLMH
uniprot id: A0A2R9B0W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9597:SORL1
gene id: 9597:SORL1
uniprot id: A0A2R8ZUE8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family. SORL1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Recycling endosome membrane
messages: Secreted
messages: multivesicular body membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

9597:CIAO1
gene id: 9597:CIAO1
uniprot id: A0A2R9CNN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9597:FSCN3
gene id: 9597:FSCN3
uniprot id: A0A2R9CGH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9597:AQR
gene id: 9597:AQR
uniprot id: A0A2R9AK31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWF11 family.
messages: Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.
messages: Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
messages: Nucleus

9597:DIPK2B
gene id: 9597:DIPK2B
uniprot id: A0A2R9BES5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9597:SEPTIN9
gene id: 9597:SEPTIN9
uniprot id: A0A2R9B1S7
uniprot id: A0A2R9B211
uniprot id: A0A2R9B3S7
uniprot id: A0A2R9B5U0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9597:CTNND1
gene id: 9597:CTNND1
uniprot id: A0A2R9CFR2
uniprot id: A0A2R9CNM6
names: Similarity
messages: Belongs to the beta-catenin family.

9597:ZNF480
gene id: 9597:ZNF480
uniprot id: A0A2R9CDR3
names: Function
messages: May be involved in transcriptional regulation.

9597:HOXB4
gene id: 9597:HOXB4
uniprot id: A0A2R9C1W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:MFAP5
gene id: 9597:MFAP5
uniprot id: A0A2R9BT75
uniprot id: A0A2R9BT81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

9597:LOC100973205
gene id: 9597:LOC100973205
uniprot id: A0A2R8ZMZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LOC100972888
gene id: 9597:LOC100972888
uniprot id: A0A2R9AY07
names: Similarity
messages: Belongs to the peptidase M16 family.

9597:PTPN22
gene id: 9597:PTPN22
uniprot id: A0A2R9B9T0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.

9597:SLC4A2
gene id: 9597:SLC4A2
uniprot id: A0A2R9CJA6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

9597:QRSL1
gene id: 9597:QRSL1
uniprot id: A0A2R9ADE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9597:PSME4
gene id: 9597:PSME4
uniprot id: A0A2R9C9E5
names: Similarity
messages: Belongs to the BLM10 family.

9597:IL33
gene id: 9597:IL33
uniprot id: A0A2R9A3H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Nucleus
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9597:ALAS1
gene id: 9597:ALAS1
uniprot id: A0A2R9CAD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9597:ZNF132
gene id: 9597:ZNF132
uniprot id: A0A2R9C8I9
names: Function
messages: May be involved in transcriptional regulation.

9597:FLI1
gene id: 9597:FLI1
uniprot id: A0A2R9C1G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:DPM2
gene id: 9597:DPM2
uniprot id: A0A2R9CL82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

9597:COPS6
gene id: 9597:COPS6
uniprot id: A0A2R9CNJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

9597:GLB1L
gene id: 9597:GLB1L
uniprot id: A0A2R9BEV6
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9597:ETNPPL
gene id: 9597:ETNPPL
uniprot id: A0A2R9AQ91
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9597:STK32A
gene id: 9597:STK32A
uniprot id: A0A2R8ZYM2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:GPNMB
gene id: 9597:GPNMB
uniprot id: A0A2R9AQ34
names: Similarity
messages: Belongs to the PMEL/NMB family.

9597:DOK3
gene id: 9597:DOK3
uniprot id: A0A2R9AEB1
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9597:INHBE
gene id: 9597:INHBE
uniprot id: A0A2R9CQH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9597:FUCA2
gene id: 9597:FUCA2
uniprot id: A0A2R9BGD3
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9597:TOB1
gene id: 9597:TOB1
uniprot id: A0A2R8ZD48
names: Similarity
messages: Belongs to the BTG family.

9597:TAS1R3
gene id: 9597:TAS1R3
uniprot id: A0A2R9B4E3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:MED10
gene id: 9597:MED10
uniprot id: A0A2R9ALB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:USO1
gene id: 9597:USO1
uniprot id: A0A2R8ZGY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

9597:BMP4
gene id: 9597:BMP4
uniprot id: A0A2R9A169
names: Similarity
messages: Belongs to the TGF-beta family.

9597:TMEM14A
gene id: 9597:TMEM14A
uniprot id: A0A2R9B801
names: Similarity
messages: Belongs to the TMEM14 family.

9597:TMEM120A
gene id: 9597:TMEM120A
uniprot id: A0A2R9B2S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9597:ETFA
gene id: 9597:ETFA
uniprot id: A0A2R9BWF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9597:TMEM138
gene id: 9597:TMEM138
uniprot id: A0A2R8Z879
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9597:POLR3GL
gene id: 9597:POLR3GL
uniprot id: A0A2R9AY48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9597:APPL1
gene id: 9597:APPL1
uniprot id: A0A2R9BK75
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9597:LOC100968447
gene id: 9597:LOC100968447
uniprot id: A0A2R8ZB01
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:GPR161
gene id: 9597:GPR161
uniprot id: A0A2R9A4J3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:ESX1
gene id: 9597:ESX1
uniprot id: A0A2R8ZPQ1
names: Subcellular Location Annotation
messages: Nucleus

9597:HR
gene id: 9597:HR
uniprot id: A0A2R9APB1
uniprot id: A0A2R9AVM6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9597:HS2ST1
gene id: 9597:HS2ST1
uniprot id: A0A2R9BUK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:MED29
gene id: 9597:MED29
uniprot id: A0A2R9BE52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

9597:HKDC1
gene id: 9597:HKDC1
uniprot id: A0A2R9B419
names: Similarity
messages: Belongs to the hexokinase family.

9597:SCAI
gene id: 9597:SCAI
uniprot id: A0A2R9B9Q3
uniprot id: A0A2R9BD35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAI family.
messages: Cytoplasm
messages: Interacts with DIAPH1. Forms a nuclear ternary complex with MRTFA and SRF.
messages: Nucleus
messages: Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity.

9597:EIF5
gene id: 9597:EIF5
uniprot id: A0A2R9BWK1
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9597:PELI1
gene id: 9597:PELI1
uniprot id: A0A2R9CTL4
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9597:SPR
gene id: 9597:SPR
uniprot id: A0A2R9BYA7
names: Similarity
messages: Belongs to the sepiapterin reductase family.

9597:KIF23
gene id: 9597:KIF23
uniprot id: A0A2R9BM71
uniprot id: A0A2R9BVE2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:NEU4
gene id: 9597:NEU4
uniprot id: A0A2R8Z5M6
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9597:CCDC153
gene id: 9597:CCDC153
uniprot id: A0A2R9BL48
names: Similarity
messages: Belongs to the UPF0610 family.

9597:SLC5A1
gene id: 9597:SLC5A1
uniprot id: A0A2R9C7G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9597:RUVBL1
gene id: 9597:RUVBL1
uniprot id: A0A2R9BYI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9597:ELK1
gene id: 9597:ELK1
uniprot id: A0A2R9CFX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:TMEM50A
gene id: 9597:TMEM50A
uniprot id: A0A2R8Z9Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9597:VASN
gene id: 9597:VASN
uniprot id: A0A2R8Z7P3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TTC38
gene id: 9597:TTC38
uniprot id: A0A2R8ZN90
names: Similarity
messages: Belongs to the TTC38 family.

9597:LOC100984482
gene id: 9597:LOC100984482
uniprot id: A0A2R9BFV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body
messages: Perikaryon
messages: Z line
messages: gem
messages: neuron projection

9597:LOC100996035
gene id: 9597:LOC100996035
uniprot id: A0A2R8ZUL1
names: Subcellular Location Annotation
messages: Secreted

9597:GCFC2
gene id: 9597:GCFC2
uniprot id: A0A2R9C7L6
names: Similarity
messages: Belongs to the GCF family.

9597:TMEM200A
gene id: 9597:TMEM200A
uniprot id: A0A2R8ZMD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9597:DCAF11
gene id: 9597:DCAF11
uniprot id: A0A2R9BTA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9597:MRPS12
gene id: 9597:MRPS12
uniprot id: A0A2R9CA13
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

9597:SLC27A3
gene id: 9597:SLC27A3
uniprot id: A0A2R8ZJU9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:MNAT1
gene id: 9597:MNAT1
uniprot id: A0A2R9B0C8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9597:LOC100990258
gene id: 9597:LOC100990258
uniprot id: A0A2R8ZYL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9597:TRIM32
gene id: 9597:TRIM32
uniprot id: A0A2R8ZPX3
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9597:GPAT4
gene id: 9597:GPAT4
uniprot id: A0A2R9A7F5
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9597:CBX8
gene id: 9597:CBX8
uniprot id: A0A2R9A1E3
names: Subcellular Location Annotation
messages: Nucleus

9597:DNAAF6
gene id: 9597:DNAAF6
uniprot id: A0A2R9CAC2
names: Similarity
messages: Belongs to the PIH1 family.

9597:EXT2
gene id: 9597:EXT2
uniprot id: A0A2R9C8P8
uniprot id: A0A2R9CGJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:FGF23
gene id: 9597:FGF23
uniprot id: A0A2R9AWI6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:CXCL2
gene id: 9597:CXCL2
uniprot id: A0A2R9BNX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:LOC100981375
gene id: 9597:LOC100981375
uniprot id: A0A2R9AUL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LEP
gene id: 9597:LEP
uniprot id: A0A2R9B6N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

9597:STRADA
gene id: 9597:STRADA
uniprot id: A0A2R9A6A2
uniprot id: A0A2R9A7H1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9597:SLC17A6
gene id: 9597:SLC17A6
uniprot id: A0A2R9ACE7
names: Subcellular Location Annotation
messages: Membrane

9597:GABRG1
gene id: 9597:GABRG1
uniprot id: A0A2R9A1L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:AFF1
gene id: 9597:AFF1
uniprot id: A0A2R9A544
names: Similarity
messages: Belongs to the AF4 family.

9597:LOC100985834
gene id: 9597:LOC100985834
uniprot id: A0A2R8ZIY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SDHAF4
gene id: 9597:SDHAF4
uniprot id: A0A2R9ALB3
names: Similarity
messages: Belongs to the SDHAF4 family.

9597:RPS15A
gene id: 9597:RPS15A
uniprot id: A0A2R9ALI7
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

9597:LOC100977118
gene id: 9597:LOC100977118
uniprot id: A0A2R8ZW54
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9597:ABCC9
gene id: 9597:ABCC9
uniprot id: A0A2R9AZ28
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KCNJ11.
messages: Membrane

9597:RPLP2
gene id: 9597:RPLP2
uniprot id: A0A2R8ZWV3
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9597:PLN
gene id: 9597:PLN
uniprot id: A0A2R8ZJ06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

9597:CD52
gene id: 9597:CD52
uniprot id: A0A2R9BPG1
names: Function
names: Subcellular Location Annotation
messages: May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
messages: Membrane

9597:MRPL33
gene id: 9597:MRPL33
uniprot id: A0A2R9AMU4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9597:GOLM1
gene id: 9597:GOLM1
uniprot id: A0A2R8ZYH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9597:LOC100990880
gene id: 9597:LOC100990880
uniprot id: A0A2R9B3Y8
names: Similarity
messages: Belongs to the UQCC4 family.

9597:PROK1
gene id: 9597:PROK1
uniprot id: A0A2R9BYR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9597:PITHD1
gene id: 9597:PITHD1
uniprot id: A0A2R9AD35
names: Similarity
messages: Belongs to the PITHD1 family.

9597:INTS10
gene id: 9597:INTS10
uniprot id: A0A2R8ZCC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9597:TMEM35B
gene id: 9597:TMEM35B
uniprot id: A0A2R8ZD25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9597:ST13
gene id: 9597:ST13
uniprot id: A0A2R8Z7Y4
names: Similarity
messages: Belongs to the FAM10 family.

9597:BCO2
gene id: 9597:BCO2
uniprot id: A0A2R9C4N2
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

9597:KLC4
gene id: 9597:KLC4
uniprot id: A0A2R9AQJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9597:CD68
gene id: 9597:CD68
uniprot id: A0A2R8ZTV8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9597:DNAL4
gene id: 9597:DNAL4
uniprot id: A0A2R9APM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9597:DOP1A
gene id: 9597:DOP1A
uniprot id: A0A2R9CE30
uniprot id: A0A2R9CM96
names: Similarity
messages: Belongs to the dopey family.

9597:PAX4
gene id: 9597:PAX4
uniprot id: A0A2R9AS32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9597:CSF3
gene id: 9597:CSF3
uniprot id: A0A2R8ZJQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
messages: Secreted

9597:TOMM40L
gene id: 9597:TOMM40L
uniprot id: A0A2R9C7B2
uniprot id: A0A2R9C7B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:RXFP1
gene id: 9597:RXFP1
uniprot id: A0A2R9CC12
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:NECAP2
gene id: 9597:NECAP2
uniprot id: A0A2R9CPP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9597:KCNE3
gene id: 9597:KCNE3
uniprot id: A0A2R8ZR49
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9597:SUCLA2
gene id: 9597:SUCLA2
uniprot id: A0A2R9BKF1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9597:LIPG
gene id: 9597:LIPG
uniprot id: A0A2R9B1A7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:HTR1E
gene id: 9597:HTR1E
uniprot id: A0A2R8ZA08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:ALDH3A2
gene id: 9597:ALDH3A2
uniprot id: A0A2R9AXA2
uniprot id: A0A2R9AZE0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9597:EPOR
gene id: 9597:EPOR
uniprot id: A0A2R9AWD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Forms homodimers on EPO stimulation.
messages: Membrane
messages: Receptor for erythropoietin.

9597:LOC100987845
gene id: 9597:LOC100987845
uniprot id: A0A2R9A3S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIBAR family.
messages: centriole
messages: cilium basal body

9597:SOAT2
gene id: 9597:SOAT2
uniprot id: A0A2R9C9S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:MRC2
gene id: 9597:MRC2
uniprot id: A0A2R8ZZ20
names: Subcellular Location Annotation
messages: Membrane

9597:RNF13
gene id: 9597:RNF13
uniprot id: A0A2R9BEY4
names: Subcellular Location Annotation
messages: Membrane

9597:KLHL40
gene id: 9597:KLHL40
uniprot id: A0A2R9CTD9
names: Similarity
names: Subcellular Location Annotation
messages: A band
messages: Belongs to the KLHL40 family.
messages: I band

9597:BBS7
gene id: 9597:BBS7
uniprot id: A0A2R9A8B3
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9597:ZSCAN25
gene id: 9597:ZSCAN25
uniprot id: A0A2R9CHA0
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:XYLB
gene id: 9597:XYLB
uniprot id: A0A2R8ZTH1
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

9597:HBEGF
gene id: 9597:HBEGF
uniprot id: A0A2R9BV62
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:PLPPR1
gene id: 9597:PLPPR1
uniprot id: A0A2R9C4A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9597:LOC100976052
gene id: 9597:LOC100976052
uniprot id: A0A2R8ZNH1
names: Similarity
messages: Belongs to the CD200R family.

9597:B3GNT5
gene id: 9597:B3GNT5
uniprot id: A0A2R8Z615
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:UBE3D
gene id: 9597:UBE3D
uniprot id: A0A2R9C4M9
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

9597:SMC1B
gene id: 9597:SMC1B
uniprot id: A0A2R8ZJD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9597:ENO1
gene id: 9597:ENO1
uniprot id: A0A2R8Z7M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9597:UBAP2L
gene id: 9597:UBAP2L
uniprot id: A0A2R8ZDM8
uniprot id: A0A2R8ZDN9
uniprot id: A0A2R8ZDP0
names: Subcellular Location Annotation
messages: Cytoplasm

9597:PMP2
gene id: 9597:PMP2
uniprot id: A0A2R9A080
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9597:EPO
gene id: 9597:EPO
uniprot id: A0A2R9CD53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Secreted

9597:FGF17
gene id: 9597:FGF17
uniprot id: A0A2R9CFH6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:CSN3
gene id: 9597:CSN3
uniprot id: A0A2R9B910
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Secreted

9597:MLLT3
gene id: 9597:MLLT3
uniprot id: A0A2R8ZRG2
names: Subcellular Location Annotation
messages: Nucleus

9597:FAM234B
gene id: 9597:FAM234B
uniprot id: A0A2R9CBW9
names: Similarity
messages: Belongs to the FAM234 family.

9597:NKX2-3
gene id: 9597:NKX2-3
uniprot id: A0A2R9B6R3
names: Subcellular Location Annotation
messages: Nucleus

9597:CNTNAP1
gene id: 9597:CNTNAP1
uniprot id: A0A2R9A9Y5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: paranodal septate junction

9597:IL2
gene id: 9597:IL2
uniprot id: A0A2R9ACE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9597:LOC100980448
gene id: 9597:LOC100980448
uniprot id: A0A2R9A5J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: cytoskeleton

9597:RBBP7
gene id: 9597:RBBP7
uniprot id: A0A2R9BC22
names: Subcellular Location Annotation
messages: Nucleus

9597:MRPL11
gene id: 9597:MRPL11
uniprot id: A0A2R9A3R3
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9597:FMO2
gene id: 9597:FMO2
uniprot id: A0A2R9B464
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9597:SLC25A44
gene id: 9597:SLC25A44
uniprot id: A0A2R8ZWJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:RFC1
gene id: 9597:RFC1
uniprot id: A0A2R9C9P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

9597:OSTC
gene id: 9597:OSTC
uniprot id: A0A2R9CSU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9597:TOMM22
gene id: 9597:TOMM22
uniprot id: A0A2R9AR74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9597:RPL24
gene id: 9597:RPL24
uniprot id: A0A2R8ZIX4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9597:TM6SF1
gene id: 9597:TM6SF1
uniprot id: A0A2R9C4W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

9597:SIX6
gene id: 9597:SIX6
uniprot id: A0A2R9CLP7
names: Subcellular Location Annotation
messages: Nucleus

9597:TMEM39B
gene id: 9597:TMEM39B
uniprot id: A0A2R9AFI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9597:DNAJC10
gene id: 9597:DNAJC10
uniprot id: A0A2R9C0F0
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.
messages: Endoplasmic reticulum lumen

9597:POLG
gene id: 9597:POLG
uniprot id: A0A2R9CIN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
messages: mitochondrion nucleoid

9597:LOC100992158
gene id: 9597:LOC100992158
uniprot id: A0A2R9C257
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9597:MSRB3
gene id: 9597:MSRB3
uniprot id: A0A2R9B061
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9597:TSEN34
gene id: 9597:TSEN34
uniprot id: A0A2R9BDN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9597:CENPK
gene id: 9597:CENPK
uniprot id: A0A2R8ZQI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

9597:GLI1
gene id: 9597:GLI1
uniprot id: A0A2R9CQM3
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9597:ENPP3
gene id: 9597:ENPP3
uniprot id: A0A2R8ZBQ0
names: Subcellular Location Annotation
messages: Secreted

9597:LALBA
gene id: 9597:LALBA
uniprot id: A0A2R9ACU0
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

9597:OXER1
gene id: 9597:OXER1
uniprot id: A0A2R8ZIX0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:CD79B
gene id: 9597:CD79B
uniprot id: A0A2R9C3B1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:JPH1
gene id: 9597:JPH1
uniprot id: A0A2R9AM33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9597:CLSPN
gene id: 9597:CLSPN
uniprot id: A0A2R9A3S2
names: Subcellular Location Annotation
messages: Nucleus

9597:KEAP1
gene id: 9597:KEAP1
uniprot id: A0A2R9BRR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

9597:LOC100984084
gene id: 9597:LOC100984084
uniprot id: A0A2R8ZHH0
names: Function
messages: May be involved in transcriptional regulation.

9597:PANX3
gene id: 9597:PANX3
uniprot id: A0A2R9A6D7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9597:DYNLRB2
gene id: 9597:DYNLRB2
uniprot id: A0A2R8ZV49
names: Similarity
messages: Belongs to the GAMAD family.

9597:PEA15
gene id: 9597:PEA15
uniprot id: A0A2R9A7G9
names: Subcellular Location Annotation
messages: Cytoplasm

9597:SIAH3
gene id: 9597:SIAH3
uniprot id: A0A2R9AIW9
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9597:SLC19A2
gene id: 9597:SLC19A2
uniprot id: A0A2R9CL39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9597:GRM3
gene id: 9597:GRM3
uniprot id: A0A2R9BG51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

9597:C18H18orf32
gene id: 9597:C18H18orf32
uniprot id: A0A2R8ZU84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: Lipid droplet
messages: May activate the NF-kappa-B signaling pathway.

9597:MTO1
gene id: 9597:MTO1
uniprot id: A0A2R9A193
uniprot id: A0A2R9A5L3
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

9597:LOC100980884
gene id: 9597:LOC100980884
uniprot id: A0A2R8Z8L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ALPP
gene id: 9597:ALPP
uniprot id: A0A2R9BU96
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9597:SLC27A2
gene id: 9597:SLC27A2
uniprot id: A0A2R9CFT6
uniprot id: A0A2R9CIF1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:RGS14
gene id: 9597:RGS14
uniprot id: A0A2R9AP20
names: Subcellular Location Annotation
messages: dendrite

9597:MAPK1IP1L
gene id: 9597:MAPK1IP1L
uniprot id: A0A2R8ZYD7
names: Similarity
messages: Belongs to the MISS family.

9597:ARGLU1
gene id: 9597:ARGLU1
uniprot id: A0A2R9ACG3
names: Similarity
messages: Belongs to the UPF0430 family.

9597:CALR
gene id: 9597:CALR
uniprot id: A0A2R8Z933
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9597:SLC31A2
gene id: 9597:SLC31A2
uniprot id: A0A2R9CTC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9597:ATG7
gene id: 9597:ATG7
uniprot id: A0A2R9C9V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

9597:SS18L2
gene id: 9597:SS18L2
uniprot id: A0A2R8ZZX6
names: Similarity
messages: Belongs to the SS18 family.

9597:MFSD6L
gene id: 9597:MFSD6L
uniprot id: A0A2R8ZHW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9597:TOMM40
gene id: 9597:TOMM40
uniprot id: A0A2R9AXI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:CPNE3
gene id: 9597:CPNE3
uniprot id: A0A2R9A005
names: Similarity
messages: Belongs to the copine family.

9597:NR2C1
gene id: 9597:NR2C1
uniprot id: A0A2R9CK29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9597:APOL6
gene id: 9597:APOL6
uniprot id: A0A2R9BVD4
names: Similarity
messages: Belongs to the apolipoprotein L family.

9597:HSPB7
gene id: 9597:HSPB7
uniprot id: A0A2R9AL15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9597:PRKCI
gene id: 9597:PRKCI
uniprot id: A0A2R9B127
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9597:IFI44
gene id: 9597:IFI44
uniprot id: A0A2R9CQT3
names: Similarity
messages: Belongs to the IFI44 family.

9597:ITIH1
gene id: 9597:ITIH1
uniprot id: A0A2R9C9J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9597:SLC25A34
gene id: 9597:SLC25A34
uniprot id: A0A2R9CBL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:SNX33
gene id: 9597:SNX33
uniprot id: A0A2R9CCK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9597:POMT2
gene id: 9597:POMT2
uniprot id: A0A2R9AB99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9597:C6
gene id: 9597:C6
uniprot id: A0A2R9B8Y5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:TMEFF2
gene id: 9597:TMEFF2
uniprot id: A0A2R8ZAT1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:KHDC1L
gene id: 9597:KHDC1L
uniprot id: A0A2R8ZQ44
names: Similarity
messages: Belongs to the KHDC1 family.

9597:TNFRSF19
gene id: 9597:TNFRSF19
uniprot id: A0A2R9ANY2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TAF12
gene id: 9597:TAF12
uniprot id: A0A2R8ZV65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9597:PPP1R10
gene id: 9597:PPP1R10
uniprot id: A0A2R9BPN9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

9597:RETREG3
gene id: 9597:RETREG3
uniprot id: A0A2R9CEP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:ATP6V0D2
gene id: 9597:ATP6V0D2
uniprot id: A0A2R9AWS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9597:TBX15
gene id: 9597:TBX15
uniprot id: A0A2R9B7V9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:SLC25A35
gene id: 9597:SLC25A35
uniprot id: A0A2R9AUY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:TYK2
gene id: 9597:TYK2
uniprot id: A0A2R9C1D6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9597:STC2
gene id: 9597:STC2
uniprot id: A0A2R9CC17
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9597:CD37
gene id: 9597:CD37
uniprot id: A0A2R9BM06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:DHRS3
gene id: 9597:DHRS3
uniprot id: A0A2R9CHQ5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:MX2
gene id: 9597:MX2
uniprot id: A0A2R9AMN8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9597:ATP1A4
gene id: 9597:ATP1A4
uniprot id: A0A2R9A102
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9597:MPEG1
gene id: 9597:MPEG1
uniprot id: A0A2R8ZKT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9597:PRDM10
gene id: 9597:PRDM10
uniprot id: A0A2R9CFJ6
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:GOLT1A
gene id: 9597:GOLT1A
uniprot id: A0A2R8ZS45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9597:TAS2R7
gene id: 9597:TAS2R7
uniprot id: Q646D6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
messages: Membrane
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

9597:CER1
gene id: 9597:CER1
uniprot id: A0A2R9BLX9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:SUGP1
gene id: 9597:SUGP1
uniprot id: A0A2R9BII1
names: Subcellular Location Annotation
messages: Nucleus

9597:NPAS4
gene id: 9597:NPAS4
uniprot id: A0A2R9B797
names: Subcellular Location Annotation
messages: Nucleus

9597:TRAPPC6A
gene id: 9597:TRAPPC6A
uniprot id: A0A2R8ZVF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9597:TMEM225B
gene id: 9597:TMEM225B
uniprot id: A0A2R9C3T4
names: Subcellular Location Annotation
messages: Membrane

9597:S100B
gene id: 9597:S100B
uniprot id: A0A2R9ADJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9597:KCNH3
gene id: 9597:KCNH3
uniprot id: A0A2R9ANM2
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9597:ZNF333
gene id: 9597:ZNF333
uniprot id: A0A2R9A239
names: Function
messages: May be involved in transcriptional regulation.

9597:ABCD1
gene id: 9597:ABCD1
uniprot id: A0A2R9C0A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9597:ELP1
gene id: 9597:ELP1
uniprot id: A0A2R8ZU92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

9597:TTYH2
gene id: 9597:TTYH2
uniprot id: A0A2R9A8B4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9597:LOC100982405
gene id: 9597:LOC100982405
uniprot id: A0A2R8ZCY2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:CSK
gene id: 9597:CSK
uniprot id: A0A2R9A3Q5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9597:PAPSS2
gene id: 9597:PAPSS2
uniprot id: A0A2R8Z6U3
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9597:LOC100983778
gene id: 9597:LOC100983778
uniprot id: A8HDH0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9597:CCS
gene id: 9597:CCS
uniprot id: A0A2R9AT42
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9597:ABRAXAS2
gene id: 9597:ABRAXAS2
uniprot id: A0A2R9AK64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abro1 subfamily.
messages: Nucleus
messages: spindle pole

9597:TLR4
gene id: 9597:TLR4
uniprot id: B3Y628
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9597:AP2B1
gene id: 9597:AP2B1
uniprot id: A0A2R9AN06
uniprot id: A0A2R9AN11
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9597:CXCL11
gene id: 9597:CXCL11
uniprot id: A0A2R9AGS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:LOC100991696
gene id: 9597:LOC100991696
uniprot id: A0A2R8ZLH9
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9597:CAP2
gene id: 9597:CAP2
uniprot id: A0A2R9AT50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9597:PSMF1
gene id: 9597:PSMF1
uniprot id: A0A2R9B9F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

9597:PPP2R5E
gene id: 9597:PPP2R5E
uniprot id: A0A2R8ZLW4
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9597:IRF2
gene id: 9597:IRF2
uniprot id: A0A2R9B110
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9597:USP20
gene id: 9597:USP20
uniprot id: A0A2R9CJ76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9597:KRT222
gene id: 9597:KRT222
uniprot id: A0A2R8ZTS0
names: Similarity
messages: Belongs to the intermediate filament family.

9597:SLC10A6
gene id: 9597:SLC10A6
uniprot id: A0A2R8Z9D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9597:ZNF330
gene id: 9597:ZNF330
uniprot id: A0A2R9C733
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: centromere
messages: nucleolus

9597:AOC1
gene id: 9597:AOC1
uniprot id: A0A2R9BA23
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9597:HDAC2
gene id: 9597:HDAC2
uniprot id: A0A2R9AS16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9597:NFE2L2
gene id: 9597:NFE2L2
uniprot id: A0A2R9BKQ1
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9597:ATG16L2
gene id: 9597:ATG16L2
uniprot id: A0A2R9CA16
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9597:PMM2
gene id: 9597:PMM2
uniprot id: A0A2R9C751
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9597:ZFP30
gene id: 9597:ZFP30
uniprot id: A0A2R9AKC8
names: Function
messages: May be involved in transcriptional regulation.

9597:ISCU
gene id: 9597:ISCU
uniprot id: A0A2R8ZZT4
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex.

9597:BLCAP
gene id: 9597:BLCAP
uniprot id: A0A2R8ZG41
names: Function
names: Similarity
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

9597:PLA2G4F
gene id: 9597:PLA2G4F
uniprot id: A0A2R9AYX5
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9597:PKM
gene id: 9597:PKM
uniprot id: A0A2R9C424
uniprot id: A0A2R9CED5
names: Similarity
messages: Belongs to the pyruvate kinase family.

9597:MEF2A
gene id: 9597:MEF2A
uniprot id: A0A2R9B3E7
uniprot id: A0A2R9B3G6
uniprot id: A0A2R9BA52
names: Subcellular Location Annotation
messages: Nucleus

9597:TMBIM6
gene id: 9597:TMBIM6
uniprot id: A0A2R9B016
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9597:SOAT1
gene id: 9597:SOAT1
uniprot id: A0A2R9BQK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:CTNNA1
gene id: 9597:CTNNA1
uniprot id: A0A2R9BTP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9597:ACSL4
gene id: 9597:ACSL4
uniprot id: A0A2R9AT86
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:KIF15
gene id: 9597:KIF15
uniprot id: A0A2R9B9F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.
messages: spindle

9597:GPC4
gene id: 9597:GPC4
uniprot id: A0A2R9BDY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9597:OPTN
gene id: 9597:OPTN
uniprot id: A0A2R9BNA4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Recycling endosome
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

9597:TMBIM4
gene id: 9597:TMBIM4
uniprot id: A0A2R9BYK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9597:MAS1
gene id: 9597:MAS1
uniprot id: A0A2R8Z7J2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:LYRM4
gene id: 9597:LYRM4
uniprot id: A0A2R9A3H3
names: Similarity
messages: Belongs to the complex I LYR family.

9597:RPAP2
gene id: 9597:RPAP2
uniprot id: A0A2R9BAV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

9597:LOC100993258
gene id: 9597:LOC100993258
uniprot id: A0A2R9AM66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TRIAP1
gene id: 9597:TRIAP1
uniprot id: A0A2R9A9I0
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

9597:UNK
gene id: 9597:UNK
uniprot id: A0A2R9APG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9597:H1-2
gene id: 9597:H1-2
uniprot id: A0A2R8ZHX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9597:TMCO3
gene id: 9597:TMCO3
uniprot id: A0A2R9B7P5
names: Subcellular Location Annotation
messages: Membrane

9597:CTH
gene id: 9597:CTH
uniprot id: A0A2R9AB45
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

9597:TEKT3
gene id: 9597:TEKT3
uniprot id: A0A2R9B626
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9597:PABIR1
gene id: 9597:PABIR1
uniprot id: A0A2R8ZCM8
names: Similarity
messages: Belongs to the FAM122 family.

9597:INPP5D
gene id: 9597:INPP5D
uniprot id: A0A2R9AEZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane

9597:PDRG1
gene id: 9597:PDRG1
uniprot id: A0A2R9A910
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9597:DNAJB14
gene id: 9597:DNAJB14
uniprot id: A0A2R9B0H0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:ANG
gene id: 9597:ANG
uniprot id: A0A2R9AQ17
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9597:SLITRK5
gene id: 9597:SLITRK5
uniprot id: A0A2R8ZM48
names: Similarity
messages: Belongs to the SLITRK family.

9597:CFAP68
gene id: 9597:CFAP68
uniprot id: A0A2R9AP44
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

9597:CNOT1
gene id: 9597:CNOT1
uniprot id: A0A2R8ZLN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

9597:SLC46A3
gene id: 9597:SLC46A3
uniprot id: A0A2R9B8A4
names: Subcellular Location Annotation
messages: Membrane

9597:ARL6IP5
gene id: 9597:ARL6IP5
uniprot id: A0A2R9AYA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9597:CLCN2
gene id: 9597:CLCN2
uniprot id: A0A2R9ALT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

9597:SYP
gene id: 9597:SYP
uniprot id: A0A2R9AYF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9597:CAPZA3
gene id: 9597:CAPZA3
uniprot id: A0A2R8ZLK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9597:UBL3
gene id: 9597:UBL3
uniprot id: A0A2R8ZU73
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:STRA6
gene id: 9597:STRA6
uniprot id: A0A2R9B7F3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:CDKN2AIP
gene id: 9597:CDKN2AIP
uniprot id: A0A2R9BXZ8
names: Similarity
messages: Belongs to the CARF family.

9597:RPS6KA2
gene id: 9597:RPS6KA2
uniprot id: A0A2R9BPU4
uniprot id: A0A2R9BYY6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9597:DGKZ
gene id: 9597:DGKZ
uniprot id: A0A2R9BS78
uniprot id: A0A2R9BSA8
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9597:CZIB
gene id: 9597:CZIB
uniprot id: A0A2R9BU24
names: Similarity
messages: Belongs to the UPF0587 family.

9597:GSDMB
gene id: 9597:GSDMB
uniprot id: A0A2R9C0Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9597:CHRNG
gene id: 9597:CHRNG
uniprot id: A0A2R9CRT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:HAP1
gene id: 9597:HAP1
uniprot id: A0A2R8ZXS7
uniprot id: A0A2R8ZYW3
names: Subcellular Location Annotation
messages: Early endosome
messages: Mitochondrion

9597:POLR1E
gene id: 9597:POLR1E
uniprot id: A0A2R9AZN3
uniprot id: A0A2R9B0X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9597:SLITRK2
gene id: 9597:SLITRK2
uniprot id: A0A2R8ZTJ6
names: Similarity
messages: Belongs to the SLITRK family.

9597:POLR1A
gene id: 9597:POLR1A
uniprot id: A0A2R9CCE6
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9597:IRAK2
gene id: 9597:IRAK2
uniprot id: A0A2R9BPE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

9597:WDR46
gene id: 9597:WDR46
uniprot id: A0A2R9AB91
names: Subcellular Location Annotation
messages: nucleolus

9597:LOC100973658
gene id: 9597:LOC100973658
uniprot id: A0A2R8ZAQ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9597:TRAPPC11
gene id: 9597:TRAPPC11
uniprot id: A0A2R9A614
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPPC11 family.
messages: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
messages: cis-Golgi network

9597:GSTT2B
gene id: 9597:GSTT2B
uniprot id: A0A2R9B3V8
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9597:LOC100978482
gene id: 9597:LOC100978482
uniprot id: A0A2R8ZP43
names: Similarity
messages: Belongs to the LCE family.

9597:CPPED1
gene id: 9597:CPPED1
uniprot id: A0A2R9B663
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

9597:PYROXD1
gene id: 9597:PYROXD1
uniprot id: A0A2R9AJQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

9597:RBM42
gene id: 9597:RBM42
uniprot id: A0A2R9BJY1
uniprot id: A0A2R9BJZ8
names: Similarity
messages: Belongs to the RRM RBM42 family.

9597:TLR2
gene id: 9597:TLR2
uniprot id: B3Y614
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
messages: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
messages: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).
messages: Membrane
messages: Membrane raft
messages: The ATG16L1-binding motif mediates interaction with ATG16L1.
messages: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.
messages: phagosome membrane

9597:TCP11L2
gene id: 9597:TCP11L2
uniprot id: A0A2R9C876
names: Similarity
messages: Belongs to the TCP11 family.

9597:PIN4
gene id: 9597:PIN4
uniprot id: A0A2R9B5P5
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

9597:ARFGEF2
gene id: 9597:ARFGEF2
uniprot id: A0A2R9B2G6
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9597:SPSB3
gene id: 9597:SPSB3
uniprot id: A0A2R8ZKW4
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9597:FAM83B
gene id: 9597:FAM83B
uniprot id: A0A2R9A0A2
names: Similarity
messages: Belongs to the FAM83 family.

9597:ST7
gene id: 9597:ST7
uniprot id: A0A2R8ZXR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9597:USP9X
gene id: 9597:USP9X
uniprot id: A0A2R9BVD0
names: Similarity
messages: Belongs to the peptidase C19 family.

9597:CCDC65
gene id: 9597:CCDC65
uniprot id: A0A2R9CJ03
names: Subcellular Location Annotation
messages: flagellum axoneme

9597:NKX6-2
gene id: 9597:NKX6-2
uniprot id: A0A2R9A5N8
names: Subcellular Location Annotation
messages: Nucleus

9597:PLXNB1
gene id: 9597:PLXNB1
uniprot id: A0A2R9BXJ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:PDIA2
gene id: 9597:PDIA2
uniprot id: A0A2R9A4R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9597:BCAT1
gene id: 9597:BCAT1
uniprot id: A0A2R9A4U2
uniprot id: A0A2R9A4U7
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9597:PLAU
gene id: 9597:PLAU
uniprot id: A0A2R9B7X2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CRYL1
gene id: 9597:CRYL1
uniprot id: A0A2R9CJ69
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9597:PHYHIPL
gene id: 9597:PHYHIPL
uniprot id: A0A2R9BWY6
names: Similarity
messages: Belongs to the PHYHIP family.

9597:SLC6A7
gene id: 9597:SLC6A7
uniprot id: A0A2R8ZDC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9597:FBXO48
gene id: 9597:FBXO48
uniprot id: A0A2R9AFG0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.

9597:PRPSAP2
gene id: 9597:PRPSAP2
uniprot id: A0A2R8ZC92
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9597:IMMP1L
gene id: 9597:IMMP1L
uniprot id: A0A2R9CKA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9597:ST6GALNAC5
gene id: 9597:ST6GALNAC5
uniprot id: A0A2R8ZNL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:DNAJB12
gene id: 9597:DNAJB12
uniprot id: A0A2R9BHL0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:PDIA3
gene id: 9597:PDIA3
uniprot id: A0A2R9AJW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9597:LOC100978613
gene id: 9597:LOC100978613
uniprot id: A0A2R8ZCD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9597:LOC100988094
gene id: 9597:LOC100988094
uniprot id: B0VYX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with AFG1L (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9597:SLC18A2
gene id: 9597:SLC18A2
uniprot id: A0A2R8ZND4
names: Subcellular Location Annotation
messages: Membrane

9597:WNT2
gene id: 9597:WNT2
uniprot id: A0A2R9AB51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:CSF2
gene id: 9597:CSF2
uniprot id: A0A2R9C4M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9597:CADM3
gene id: 9597:CADM3
uniprot id: A0A2R9CIJ2
uniprot id: A0A2R9CL84
names: Similarity
messages: Belongs to the nectin family.

9597:CD5
gene id: 9597:CD5
uniprot id: A0A2R9BYS6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CBX1
gene id: 9597:CBX1
uniprot id: A0A2R9AGT2
names: Subcellular Location Annotation
messages: Nucleus

9597:SPTSSB
gene id: 9597:SPTSSB
uniprot id: A0A2R8ZA07
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:ZKSCAN5
gene id: 9597:ZKSCAN5
uniprot id: A0A2R9B6Z1
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:ACE
gene id: 9597:ACE
uniprot id: A0A2R8ZYP1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.

9597:ANXA2
gene id: 9597:ANXA2
uniprot id: A0A2R9CNI1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Membrane
messages: basement membrane

9597:CACHD1
gene id: 9597:CACHD1
uniprot id: A0A2R8ZDU7
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9597:KIF12
gene id: 9597:KIF12
uniprot id: A0A2R9C130
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:DEFB126
gene id: 9597:DEFB126
uniprot id: A0A2R9BSS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9597:KIF11
gene id: 9597:KIF11
uniprot id: A0A2R9CQJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle pole

9597:PPP2R5C
gene id: 9597:PPP2R5C
uniprot id: A0A2R9BML8
uniprot id: A0A2R9BNF8
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9597:HSD17B4
gene id: 9597:HSD17B4
uniprot id: A0A2R9C8G1
uniprot id: A0A2R9CB89
names: Subcellular Location Annotation
messages: Peroxisome

9597:LOC100987402
gene id: 9597:LOC100987402
uniprot id: A0A2R8ZUA2
names: Function
messages: May be involved in transcriptional regulation.

9597:PEX3
gene id: 9597:PEX3
uniprot id: A0A2R8ZY46
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9597:FAR2
gene id: 9597:FAR2
uniprot id: A0A2R9BUJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9597:RAB43
gene id: 9597:RAB43
uniprot id: A0A2R8ZSR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane

9597:CLDN34
gene id: 9597:CLDN34
uniprot id: A0A2R8ZI17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9597:PPP1R3B
gene id: 9597:PPP1R3B
uniprot id: A0A2R9AP01
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9597:OPN1SW
gene id: 9597:OPN1SW
uniprot id: P60573
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Cell membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Photoreceptor inner segment
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (By similarity). Involved in ensuring correct abundance and localization of retinal membrane proteins (By similarity). May increase spectral sensitivity in dim light (By similarity).
messages: perinuclear region
messages: photoreceptor outer segment

9597:SATB2
gene id: 9597:SATB2
uniprot id: A0A2R9CTC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9597:FAM241B
gene id: 9597:FAM241B
uniprot id: A0A2R9B1J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9597:LIPK
gene id: 9597:LIPK
uniprot id: A0A2R9AIS3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9597:EIF3H
gene id: 9597:EIF3H
uniprot id: A0A2R8Z9B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9597:TSPAN4
gene id: 9597:TSPAN4
uniprot id: A0A2R9B448
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:AGMAT
gene id: 9597:AGMAT
uniprot id: A0A2R9A166
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

9597:PKP1
gene id: 9597:PKP1
uniprot id: A0A2R8ZE41
names: Similarity
messages: Belongs to the beta-catenin family.

9597:ASPN
gene id: 9597:ASPN
uniprot id: A0A2R9B818
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9597:STAC2
gene id: 9597:STAC2
uniprot id: A0A2R9ADP0
names: Subcellular Location Annotation
messages: sarcolemma

9597:AREG
gene id: 9597:AREG
uniprot id: A0A2R9CBP5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:HTR6
gene id: 9597:HTR6
uniprot id: A0A2R8ZAV3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:MYO1C
gene id: 9597:MYO1C
uniprot id: A0A2R8ZVX3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:MED24
gene id: 9597:MED24
uniprot id: A0A2R9AK79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9597:BDNF
gene id: 9597:BDNF
uniprot id: A0A2R9A467
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
messages: Monomers and homodimers. Binds to NTRK2/TRKB.
messages: Secreted

9597:CA8
gene id: 9597:CA8
uniprot id: A0A2R9BI01
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9597:LDHC
gene id: 9597:LDHC
uniprot id: A0A2R9BKE8
uniprot id: A0A2R9BUA1
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9597:RPL13A
gene id: 9597:RPL13A
uniprot id: A0A2R9BPU7
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9597:PEX2
gene id: 9597:PEX2
uniprot id: A0A2R9ARI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9597:PSMB8
gene id: 9597:PSMB8
uniprot id: A0A2R9CBN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9597:HACD4
gene id: 9597:HACD4
uniprot id: A0A2R9BPY9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:VASP
gene id: 9597:VASP
uniprot id: A0A2R9BN03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

9597:PSMB6
gene id: 9597:PSMB6
uniprot id: A0A2R9CGY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9597:AMT
gene id: 9597:AMT
uniprot id: A0A2R9BRU1
uniprot id: A0A2R9BVB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9597:CIAO2A
gene id: 9597:CIAO2A
uniprot id: A0A2R8ZR21
uniprot id: A0A2R8ZVQ9
names: Similarity
messages: Belongs to the MIP18 family.

9597:PIK3C2A
gene id: 9597:PIK3C2A
uniprot id: A0A2R9BSX3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9597:ACADS
gene id: 9597:ACADS
uniprot id: A0A2R8ZI63
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9597:RPS26
gene id: 9597:RPS26
uniprot id: A0A2R9BFK5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9597:B4GAT1
gene id: 9597:B4GAT1
uniprot id: A0A2R9BXA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:CXCL6
gene id: 9597:CXCL6
uniprot id: A0A2R9BGM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:ITGB2
gene id: 9597:ITGB2
uniprot id: A0A2R9B178
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft

9597:LRP10
gene id: 9597:LRP10
uniprot id: A0A2R9AA34
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:PPP2R2B
gene id: 9597:PPP2R2B
uniprot id: A0A2R9CFA8
uniprot id: A0A2R9CI09
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9597:GTF2A1L
gene id: 9597:GTF2A1L
uniprot id: A0A2R8ZRW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9597:RBBP4
gene id: 9597:RBBP4
uniprot id: A0A2R9BXZ7
names: Subcellular Location Annotation
messages: Nucleus

9597:ERGIC2
gene id: 9597:ERGIC2
uniprot id: A0A2R9ABJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9597:ACTR5
gene id: 9597:ACTR5
uniprot id: A0A2R8Z991
names: Similarity
messages: Belongs to the actin family.

9597:SH3GL3
gene id: 9597:SH3GL3
uniprot id: A0A2R8Z992
uniprot id: A0A2R8Z996
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9597:CSTF2
gene id: 9597:CSTF2
uniprot id: A0A2R9AJ77
uniprot id: A0A2R9AJ87
names: Subcellular Location Annotation
messages: Nucleus

9597:CLSTN3
gene id: 9597:CLSTN3
uniprot id: A0A2R9AML8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

9597:BBS5
gene id: 9597:BBS5
uniprot id: A0A2R9BW62
uniprot id: A0A2R9BWT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9597:BUD13
gene id: 9597:BUD13
uniprot id: A0A2R9C569
names: Similarity
messages: Belongs to the CWC26 family.

9597:CNTNAP4
gene id: 9597:CNTNAP4
uniprot id: A0A2R8ZDR2
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:BET1L
gene id: 9597:BET1L
uniprot id: A0A2R8ZEA9
names: Subcellular Location Annotation
messages: Membrane

9597:RPS6KA6
gene id: 9597:RPS6KA6
uniprot id: A0A2R8ZB76
uniprot id: A0A2R8ZI06
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9597:MON1A
gene id: 9597:MON1A
uniprot id: A0A2R8ZDN4
uniprot id: A0A2R8ZJV7
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9597:GABARAP
gene id: 9597:GABARAP
uniprot id: A0A2R9AE68
names: Similarity
messages: Belongs to the ATG8 family.

9597:LOC100976343
gene id: 9597:LOC100976343
uniprot id: A0A2R9C308
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

9597:BTK
gene id: 9597:BTK
uniprot id: A0A2R9BPC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9597:GAL
gene id: 9597:GAL
uniprot id: A0A2R9ADP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

9597:NDUFB7
gene id: 9597:NDUFB7
uniprot id: A0A2R9CLC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9597:VPS25
gene id: 9597:VPS25
uniprot id: A0A2R9B279
names: Similarity
messages: Belongs to the VPS25 family.

9597:ESRRA
gene id: 9597:ESRRA
uniprot id: A0A2R9BL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9597:INSL5
gene id: 9597:INSL5
uniprot id: A0A2R8ZN15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9597:PTPRG
gene id: 9597:PTPRG
uniprot id: A0A2R9BDA7
uniprot id: A0A2R9BLW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9597:GABRE
gene id: 9597:GABRE
uniprot id: A0A2R8ZSJ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:CEP19
gene id: 9597:CEP19
uniprot id: A0A2R9BMC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9597:SMARCB1
gene id: 9597:SMARCB1
uniprot id: A0A2R9A3R9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

9597:VPS52
gene id: 9597:VPS52
uniprot id: A0A2R9BVC3
names: Similarity
messages: Belongs to the VPS52 family.

9597:TASP1
gene id: 9597:TASP1
uniprot id: A0A2R9C3Z2
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9597:LOC100988840
gene id: 9597:LOC100988840
uniprot id: A0A2R9B807
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:ATP2B4
gene id: 9597:ATP2B4
uniprot id: A0A2R9C7M1
uniprot id: A0A2R9CF82
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:HOOK2
gene id: 9597:HOOK2
uniprot id: A0A2R8ZAL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9597:EME1
gene id: 9597:EME1
uniprot id: A0A2R9CGG2
names: Similarity
messages: Belongs to the EME1/MMS4 family.

9597:CXXC5
gene id: 9597:CXXC5
uniprot id: A0A2R8ZN63
names: Subcellular Location Annotation
messages: Cytoplasm

9597:NEK9
gene id: 9597:NEK9
uniprot id: A0A2R8ZH82
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9597:RUNX1T1
gene id: 9597:RUNX1T1
uniprot id: A0A2R9AHT1
uniprot id: A0A2R9APW9
uniprot id: A0A2R9APX5
names: Similarity
messages: Belongs to the CBFA2T family.

9597:UBE2E2
gene id: 9597:UBE2E2
uniprot id: A0A2R9AB22
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:GUCY1A1
gene id: 9597:GUCY1A1
uniprot id: A0A2R9B7A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9597:RIC8A
gene id: 9597:RIC8A
uniprot id: A0A2R9C423
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9597:AIPL1
gene id: 9597:AIPL1
uniprot id: Q95MN9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with NUB1.
messages: May be important in protein trafficking and/or protein folding and stabilization.
messages: Nucleus

9597:PSMA4
gene id: 9597:PSMA4
uniprot id: A0A2R8ZRW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9597:PMCH
gene id: 9597:PMCH
uniprot id: B5LWR6
names: Similarity
messages: Belongs to the melanin-concentrating hormone family.

9597:RPL10A
gene id: 9597:RPL10A
uniprot id: A0A2R8ZCW8
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9597:LOC100994493
gene id: 9597:LOC100994493
uniprot id: A0A2R8Z791
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

9597:LOC100986643
gene id: 9597:LOC100986643
uniprot id: A0A2R8ZPT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:PEDS1
gene id: 9597:PEDS1
uniprot id: A0A2R9A6Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9597:VRTN
gene id: 9597:VRTN
uniprot id: A0A2R8ZG53
names: Similarity
messages: Belongs to the vertnin family.

9597:RPS19
gene id: 9597:RPS19
uniprot id: A0A2R9C3Q8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

9597:ABHD2
gene id: 9597:ABHD2
uniprot id: A0A2R9CQN6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9597:EFNA4
gene id: 9597:EFNA4
uniprot id: A0A2R8ZSX4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:IL6R
gene id: 9597:IL6R
uniprot id: A0A2R9A372
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.
messages: Membrane

9597:AASS
gene id: 9597:AASS
uniprot id: A0A2R9CGH5
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9597:SLC7A11
gene id: 9597:SLC7A11
uniprot id: A0A2R9C3C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9597:CLEC12A
gene id: 9597:CLEC12A
uniprot id: A0A2R8ZC44
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:LOC100976988
gene id: 9597:LOC100976988
uniprot id: A0A2R8ZPB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:VPS11
gene id: 9597:VPS11
uniprot id: A0A2R8ZI53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9597:BRMS1
gene id: 9597:BRMS1
uniprot id: A0A2R9B3T4
names: Subcellular Location Annotation
messages: Nucleus

9597:SRFBP1
gene id: 9597:SRFBP1
uniprot id: A0A2R9B8L8
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9597:LOC100973863
gene id: 9597:LOC100973863
uniprot id: A0A2R9A6B4
uniprot id: A0A2R9A6C2
uniprot id: A0A2R9ABM0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9597:SIRT2
gene id: 9597:SIRT2
uniprot id: A0A2R9B8Q6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

9597:OXSM
gene id: 9597:OXSM
uniprot id: A0A2R9APM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9597:CD82
gene id: 9597:CD82
uniprot id: A0A2R8ZRD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:SERPINA7
gene id: 9597:SERPINA7
uniprot id: A0A2R9BCB8
names: Similarity
messages: Belongs to the serpin family.

9597:RPL37
gene id: 9597:RPL37
uniprot id: A0A2R9AFB3
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9597:TADA1
gene id: 9597:TADA1
uniprot id: A0A2R9CFK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

9597:LOC100983089
gene id: 9597:LOC100983089
uniprot id: A0A2R8ZRU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ROM1
gene id: 9597:ROM1
uniprot id: A0A2R9B4T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9597:RHOT1
gene id: 9597:RHOT1
uniprot id: A0A2R8ZZU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9597:SFMBT1
gene id: 9597:SFMBT1
uniprot id: A0A2R8Z8J9
names: Subcellular Location Annotation
messages: Nucleus

9597:GTF2E1
gene id: 9597:GTF2E1
uniprot id: A0A2R9AIJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIE alpha subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

9597:DDX43
gene id: 9597:DDX43
uniprot id: A0A2R9AXQ3
names: Similarity
messages: Belongs to the DEAD box helicase family.

9597:LOC100971765
gene id: 9597:LOC100971765
uniprot id: A0A2R9ASP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SNX21
gene id: 9597:SNX21
uniprot id: A0A2R9A0Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Membrane

9597:MCM2
gene id: 9597:MCM2
uniprot id: A0A2R8ZAB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9597:GALNT5
gene id: 9597:GALNT5
uniprot id: A0A2R9C4V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9597:TBX5
gene id: 9597:TBX5
uniprot id: A0A2R9A5H2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:CFB
gene id: 9597:CFB
uniprot id: A0A2R9CIE9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:SLC35B3
gene id: 9597:SLC35B3
uniprot id: A0A2R9BWX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9597:VTI1B
gene id: 9597:VTI1B
uniprot id: A0A2R8ZP56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9597:HINT2
gene id: 9597:HINT2
uniprot id: A0A2R8ZB15
names: Similarity
messages: Belongs to the HINT family.

9597:BEX5
gene id: 9597:BEX5
uniprot id: A0A2R8ZIF4
names: Similarity
messages: Belongs to the BEX family.

9597:ZNF500
gene id: 9597:ZNF500
uniprot id: A0A2R9B9G5
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:SCP2
gene id: 9597:SCP2
uniprot id: A0A2R9CE57
uniprot id: A0A2R9CP81
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion

9597:PTP4A3
gene id: 9597:PTP4A3
uniprot id: A0A2R9BUK7
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9597:TAGLN
gene id: 9597:TAGLN
uniprot id: A0A2R9CFE8
names: Similarity
messages: Belongs to the calponin family.

9597:INO80C
gene id: 9597:INO80C
uniprot id: A0A2R8ZHV8
uniprot id: A0A2R8ZKZ6
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100972512
gene id: 9597:LOC100972512
uniprot id: A0A2R8ZLR5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9597:ZC2HC1C
gene id: 9597:ZC2HC1C
uniprot id: A0A2R9AN57
names: Similarity
messages: Belongs to the ZC2HC1 family.

9597:ECHS1
gene id: 9597:ECHS1
uniprot id: A0A2R9BD22
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9597:PRUNE1
gene id: 9597:PRUNE1
uniprot id: A0A2R9AX72
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9597:ICOS
gene id: 9597:ICOS
uniprot id: A0A2R9BIK8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9597:CCNB2
gene id: 9597:CCNB2
uniprot id: A0A2R9BSA0
names: Similarity
messages: Belongs to the cyclin family.

9597:ANXA6
gene id: 9597:ANXA6
uniprot id: A0A2R9ALV5
uniprot id: A0A2R9AMH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

9597:NFYA
gene id: 9597:NFYA
uniprot id: A0A2R9C7U1
uniprot id: A0A2R9CID0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9597:EDN2
gene id: 9597:EDN2
uniprot id: A0A2R9BUZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9597:UCN3
gene id: 9597:UCN3
uniprot id: A0A2R8ZEH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9597:SLC6A6
gene id: 9597:SLC6A6
uniprot id: A0A2R9C9K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

9597:MBD4
gene id: 9597:MBD4
uniprot id: A0A2R9BJD0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with MLH1.
messages: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
messages: Nucleus

9597:PDE10A
gene id: 9597:PDE10A
uniprot id: A0A2R9AYB4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:RNF40
gene id: 9597:RNF40
uniprot id: A0A2R8ZS60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9597:CAV3
gene id: 9597:CAV3
uniprot id: A0A2R9C7C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9597:NPPA
gene id: 9597:NPPA
uniprot id: A0A2R9BL40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

9597:LOC100977661
gene id: 9597:LOC100977661
uniprot id: A0A2R8ZDU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CLU
gene id: 9597:CLU
uniprot id: A0A2R9AC29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.
messages: Membrane
messages: Microsome
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9597:SLC16A4
gene id: 9597:SLC16A4
uniprot id: A0A2R9B6J2
uniprot id: A0A2R9B803
uniprot id: A0A2R9B808
names: Subcellular Location Annotation
messages: Membrane

9597:RIBC1
gene id: 9597:RIBC1
uniprot id: A0A2R9CGR9
uniprot id: A0A2R9CJG0
names: Similarity
messages: Belongs to the RIB43A family.

9597:ZNF432
gene id: 9597:ZNF432
uniprot id: A0A2R9B526
names: Function
messages: May be involved in transcriptional regulation.

9597:CYP2S1
gene id: 9597:CYP2S1
uniprot id: A0A2R9AFV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9597:GLRX
gene id: 9597:GLRX
uniprot id: A0A2R9CS70
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9597:GINS1
gene id: 9597:GINS1
uniprot id: A0A2R9BV29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9597:INPP5K
gene id: 9597:INPP5K
uniprot id: A0A2R9CCA5
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9597:ALDH6A1
gene id: 9597:ALDH6A1
uniprot id: A0A2R9AAJ7
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9597:HIGD1A
gene id: 9597:HIGD1A
uniprot id: A0A2R8ZSI2
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9597:SETD7
gene id: 9597:SETD7
uniprot id: A0A2R8ZT30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9597:MTX2
gene id: 9597:MTX2
uniprot id: A0A2R9CH73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:LOC100972317
gene id: 9597:LOC100972317
uniprot id: A0A2R8ZDW3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:LYSET
gene id: 9597:LYSET
uniprot id: A0A2R9B5M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LYSET family.
messages: Membrane

9597:ABITRAM
gene id: 9597:ABITRAM
uniprot id: A0A2R9A253
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9597:SCN3A
gene id: 9597:SCN3A
uniprot id: A0A2R8ZIK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9597:DOCK4
gene id: 9597:DOCK4
uniprot id: A0A2R9C4S8
names: Similarity
messages: Belongs to the DOCK family.

9597:SMPDL3A
gene id: 9597:SMPDL3A
uniprot id: A0A2R8ZKG5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9597:ALOX5
gene id: 9597:ALOX5
uniprot id: A0A2R9C5L7
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:QTRT1
gene id: 9597:QTRT1
uniprot id: A0A2R9ABY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane

9597:PARP6
gene id: 9597:PARP6
uniprot id: A0A2R9CPY3
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:AQP9
gene id: 9597:AQP9
uniprot id: A0A2R9CLD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9597:EVX1
gene id: 9597:EVX1
uniprot id: A0A2R8ZPS1
names: Subcellular Location Annotation
messages: Nucleus

9597:ILVBL
gene id: 9597:ILVBL
uniprot id: A0A2R9AGX9
names: Similarity
messages: Belongs to the TPP enzyme family.

9597:STK4
gene id: 9597:STK4
uniprot id: A0A2R8ZVK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9597:GAD1
gene id: 9597:GAD1
uniprot id: A0A2R9B9E1
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9597:SLC7A8
gene id: 9597:SLC7A8
uniprot id: A0A2R9A4Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9597:ERAP2
gene id: 9597:ERAP2
uniprot id: A0A2R9A7J6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9597:ADGRG1
gene id: 9597:ADGRG1
uniprot id: A0A2R8ZWN6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

9597:SAMM50
gene id: 9597:SAMM50
uniprot id: A0A2R9A8J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

9597:XKR9
gene id: 9597:XKR9
uniprot id: A0A2R9B9M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9597:SVEP1
gene id: 9597:SVEP1
uniprot id: A0A2R9ABC8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:IBSP
gene id: 9597:IBSP
uniprot id: A0A2R9BPW7
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9597:STK38
gene id: 9597:STK38
uniprot id: A0A2R9BT32
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:RUVBL2
gene id: 9597:RUVBL2
uniprot id: A0A2R9BQN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9597:NFKB2
gene id: 9597:NFKB2
uniprot id: A0A2R9ACD8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:TMTC2
gene id: 9597:TMTC2
uniprot id: A0A2R9CJX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9597:FGF12
gene id: 9597:FGF12
uniprot id: A0A2R9BAP4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:ZNF776
gene id: 9597:ZNF776
uniprot id: A0A2R8ZSR4
names: Function
messages: May be involved in transcriptional regulation.

9597:UROS
gene id: 9597:UROS
uniprot id: A0A2R9A8M7
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9597:PFKFB2
gene id: 9597:PFKFB2
uniprot id: A0A2R9CAA0
uniprot id: A0A2R9CI35
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9597:DIS3
gene id: 9597:DIS3
uniprot id: A0A2R9C8K9
uniprot id: A0A2R9CB13
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9597:FABP2
gene id: 9597:FABP2
uniprot id: A0A2R8ZM56
names: Function
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

9597:TM9SF2
gene id: 9597:TM9SF2
uniprot id: A0A2R9A9P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9597:TMEM33
gene id: 9597:TMEM33
uniprot id: A0A2R8Z5N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9597:RPAIN
gene id: 9597:RPAIN
uniprot id: A0A2R9AGI4
uniprot id: A0A2R9AGJ0
uniprot id: A0A2R9ANB9
names: Subcellular Location Annotation
messages: Nucleus

9597:B4GALT2
gene id: 9597:B4GALT2
uniprot id: A0A2R9BWS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9597:UBIAD1
gene id: 9597:UBIAD1
uniprot id: A0A2R9CKG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9597:PIK3CG
gene id: 9597:PIK3CG
uniprot id: A0A2R9CFV4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9597:STX6
gene id: 9597:STX6
uniprot id: A0A2R9CDK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9597:PAPOLG
gene id: 9597:PAPOLG
uniprot id: A0A2R8ZJ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

9597:ZNF263
gene id: 9597:ZNF263
uniprot id: A0A2R9ATI4
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:LYRM1
gene id: 9597:LYRM1
uniprot id: A0A2R9AIH7
names: Similarity
messages: Belongs to the complex I LYR family.

9597:VIP
gene id: 9597:VIP
uniprot id: A0A2R9AEX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9597:IL13
gene id: 9597:IL13
uniprot id: A0A2R9AD54
uniprot id: A0A2R9AD95
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-4/IL-13 family.
messages: Interacts with IL13RA2.
messages: Secreted

9597:AS3MT
gene id: 9597:AS3MT
uniprot id: A0A2R9CA94
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

9597:CBL
gene id: 9597:CBL
uniprot id: A0A2R9BP66
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9597:BST1
gene id: 9597:BST1
uniprot id: A0A2R9B8H2
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9597:NUPR1
gene id: 9597:NUPR1
uniprot id: A0A2R9AQR1
names: Similarity
messages: Belongs to the NUPR family.

9597:UCMA
gene id: 9597:UCMA
uniprot id: A0A2R9A5B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

9597:AGA
gene id: 9597:AGA
uniprot id: A0A2R9BM07
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9597:NCBP1
gene id: 9597:NCBP1
uniprot id: A0A2R8ZS19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

9597:LOC100975235
gene id: 9597:LOC100975235
uniprot id: A0A2R8ZAW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:KRT72
gene id: 9597:KRT72
uniprot id: A0A2R9CPA3
names: Similarity
messages: Belongs to the intermediate filament family.

9597:CSNK1A1L
gene id: 9597:CSNK1A1L
uniprot id: A0A2R8ZLE3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:APOH
gene id: 9597:APOH
uniprot id: A0A2R9C3R2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:PPP2R3C
gene id: 9597:PPP2R3C
uniprot id: A0A2R9AFJ5
names: Subcellular Location Annotation
messages: Nucleus

9597:CACNA2D1
gene id: 9597:CACNA2D1
uniprot id: A0A2R8ZS28
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9597:LOC100994139
gene id: 9597:LOC100994139
uniprot id: A0A2R9ABR9
names: Similarity
messages: Belongs to the folate receptor family.

9597:NOX5
gene id: 9597:NOX5
uniprot id: A0A2R9BPS1
names: Subcellular Location Annotation
messages: Membrane

9597:IARS2
gene id: 9597:IARS2
uniprot id: A0A2R9A7Y9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:ATG101
gene id: 9597:ATG101
uniprot id: A0A2R8ZUP9
names: Similarity
messages: Belongs to the ATG101 family.

9597:SPP1
gene id: 9597:SPP1
uniprot id: A0A2R9BYD7
uniprot id: A0A2R9BYZ3
uniprot id: A0A2R9C8E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteopontin family.
messages: Secreted

9597:CRK
gene id: 9597:CRK
uniprot id: A0A2R9A9X4
names: Similarity
messages: Belongs to the CRK family.

9597:GRK3
gene id: 9597:GRK3
uniprot id: A0A2R9A3T4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9597:GLO1
gene id: 9597:GLO1
uniprot id: A0A2R9BBA5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9597:GPRC5A
gene id: 9597:GPRC5A
uniprot id: A0A2R9AIZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:GPN1
gene id: 9597:GPN1
uniprot id: A0A2R8ZRV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

9597:ADH1B
gene id: 9597:ADH1B
uniprot id: A0A2R9BG66
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9597:PDGFB
gene id: 9597:PDGFB
uniprot id: A0A2R9ACQ2
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9597:B4GALT3
gene id: 9597:B4GALT3
uniprot id: A0A2R9AR93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9597:LOC100995923
gene id: 9597:LOC100995923
uniprot id: A0A2R9BSV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9597:GFM2
gene id: 9597:GFM2
uniprot id: A0A2R9BBQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9597:PHB1
gene id: 9597:PHB1
uniprot id: A0A2R8ZR25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9597:SEMA3F
gene id: 9597:SEMA3F
uniprot id: A0A2R9CH72
uniprot id: A0A2R9CH76
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100993304
gene id: 9597:LOC100993304
uniprot id: A0A2R8ZFL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ZNF655
gene id: 9597:ZNF655
uniprot id: A0A2R9CHV3
names: Function
messages: May be involved in transcriptional regulation.

9597:RNF7
gene id: 9597:RNF7
uniprot id: A0A2R9BAE1
names: Similarity
messages: Belongs to the RING-box family.

9597:ADGRL4
gene id: 9597:ADGRL4
uniprot id: A0A2R9CMJ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TGFBI
gene id: 9597:TGFBI
uniprot id: A0A2R9B390
names: Subcellular Location Annotation
messages: extracellular matrix

9597:DNASE2
gene id: 9597:DNASE2
uniprot id: A0A2R9AXV7
names: Similarity
messages: Belongs to the DNase II family.

9597:PGS1
gene id: 9597:PGS1
uniprot id: A0A2R9AEN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

9597:AP1G2
gene id: 9597:AP1G2
uniprot id: A0A2R9AE73
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9597:MLST8
gene id: 9597:MLST8
uniprot id: A0A2R9ASY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9597:REV3L
gene id: 9597:REV3L
uniprot id: A0A2R9B4X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9597:TECRL
gene id: 9597:TECRL
uniprot id: A0A2R9BR07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

9597:MTOR
gene id: 9597:MTOR
uniprot id: A0A2R9BI87
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9597:HBA2
gene id: 9597:HBA2
uniprot id: P69906
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Gives blood its red color.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
messages: Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA); two alpha chains and two delta chains in adult hemoglobin A2 (HbA2); two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two alpha chains and two gamma chains in fetal hemoglobin F (HbF).
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

9597:METTL8
gene id: 9597:METTL8
uniprot id: A0A2R9AB17
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9597:SCAMP2
gene id: 9597:SCAMP2
uniprot id: A0A2R9A3R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9597:MTMR9
gene id: 9597:MTMR9
uniprot id: A0A2R8ZTD2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9597:RSRP1
gene id: 9597:RSRP1
uniprot id: A0A2R9ACL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RSRP family.
messages: Nucleus
messages: Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6.

9597:PTPN21
gene id: 9597:PTPN21
uniprot id: A0A2R9B463
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9597:IGFBP5
gene id: 9597:IGFBP5
uniprot id: A0A2R8ZQV0
names: Caution
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:B4GALT7
gene id: 9597:B4GALT7
uniprot id: A0A2R9CIW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9597:INTS12
gene id: 9597:INTS12
uniprot id: A0A2R9C2D4
names: Similarity
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

9597:DUSP13B
gene id: 9597:DUSP13B
uniprot id: A0A2R8ZDD0
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9597:TH
gene id: 9597:TH
uniprot id: A0A2R9BE28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: axon
messages: perinuclear region
messages: synaptic vesicle

9597:PHGDH
gene id: 9597:PHGDH
uniprot id: A0A2R9C2H1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9597:TNFSF8
gene id: 9597:TNFSF8
uniprot id: A0A2R9CJ75
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9597:GHRH
gene id: 9597:GHRH
uniprot id: A0A2R9B5V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9597:CDX2
gene id: 9597:CDX2
uniprot id: A0A2R9AQ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9597:ADSS2
gene id: 9597:ADSS2
uniprot id: A0A2R9B5Q0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9597:EIF2B5
gene id: 9597:EIF2B5
uniprot id: A0A2R9AD93
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

9597:CDR2L
gene id: 9597:CDR2L
uniprot id: A0A2R9C5B2
names: Similarity
messages: Belongs to the CDR2 family.

9597:ATG9A
gene id: 9597:ATG9A
uniprot id: A0A2R9BA63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9597:TMEM230
gene id: 9597:TMEM230
uniprot id: A0A2R9AAV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9597:AGXT
gene id: 9597:AGXT
uniprot id: A0A2R8ZTW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Peroxisome

9597:VCP
gene id: 9597:VCP
uniprot id: A0A2R9C1U9
names: Similarity
messages: Belongs to the AAA ATPase family.

9597:EXOG
gene id: 9597:EXOG
uniprot id: A0A2R9AWM6
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9597:NTHL1
gene id: 9597:NTHL1
uniprot id: A0A2R8Z7L4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Interacts with YBX1.
messages: Mitochondrion
messages: Nucleus

9597:SLC6A1
gene id: 9597:SLC6A1
uniprot id: A0A2R9CH47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9597:PARP8
gene id: 9597:PARP8
uniprot id: A0A2R9A9J6
uniprot id: A0A2R9AF07
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:QPCT
gene id: 9597:QPCT
uniprot id: A0A2R9AL20
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9597:UBP1
gene id: 9597:UBP1
uniprot id: A0A2R8ZZJ8
uniprot id: A0A2R9A0P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9597:CPA6
gene id: 9597:CPA6
uniprot id: A0A2R9BZG7
names: Similarity
messages: Belongs to the peptidase M14 family.

9597:UST
gene id: 9597:UST
uniprot id: A0A2R8ZVZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:DCAF1
gene id: 9597:DCAF1
uniprot id: A0A2R8ZTG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPRBP/DCAF1 family.
messages: Nucleus

9597:DMGDH
gene id: 9597:DMGDH
uniprot id: A0A2R8ZK34
names: Similarity
messages: Belongs to the GcvT family.

9597:HMOX2
gene id: 9597:HMOX2
uniprot id: A0A2R8ZZ65
names: Similarity
messages: Belongs to the heme oxygenase family.

9597:HESX1
gene id: 9597:HESX1
uniprot id: A0A2R8ZZ78
uniprot id: A1YGA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ANF homeobox family.
messages: Can form heterodimers with PROP1 in binding to DNA. Interacts with TLE1 (By similarity).
messages: Nucleus
messages: Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).

9597:EFHC1
gene id: 9597:EFHC1
uniprot id: A0A2R8ZBJ6
uniprot id: A0A2R8ZBM0
names: Subcellular Location Annotation
messages: cilium axoneme

9597:VWCE
gene id: 9597:VWCE
uniprot id: A0A2R9B0G7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:STARD6
gene id: 9597:STARD6
uniprot id: A0A2R9ABZ8
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9597:RTN4IP1
gene id: 9597:RTN4IP1
uniprot id: A0A2R9AN49
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9597:LCE3A
gene id: 9597:LCE3A
uniprot id: A0A2R8ZEP1
names: Similarity
messages: Belongs to the LCE family.

9597:MEA1
gene id: 9597:MEA1
uniprot id: A0A2R9CF16
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

9597:MANBA
gene id: 9597:MANBA
uniprot id: A0A2R9A4B3
uniprot id: A0A2R9A5H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

9597:C9H9orf131
gene id: 9597:C9H9orf131
uniprot id: A0A2R9BGE3
names: Similarity
messages: Belongs to the SPATA31 family.

9597:ATP6V0D1
gene id: 9597:ATP6V0D1
uniprot id: A0A2R9BWI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9597:CDK5RAP1
gene id: 9597:CDK5RAP1
uniprot id: A0A2R8ZEK1
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

9597:PIWIL2
gene id: 9597:PIWIL2
uniprot id: W0HFS1
names: Similarity
messages: Belongs to the argonaute family.

9597:IL17B
gene id: 9597:IL17B
uniprot id: A0A2R9AYH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9597:SCFD1
gene id: 9597:SCFD1
uniprot id: A0A2R9CCU5
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9597:IRF8
gene id: 9597:IRF8
uniprot id: A0A2R9B2H7
names: Subcellular Location Annotation
messages: Nucleus

9597:CAPRIN2
gene id: 9597:CAPRIN2
uniprot id: A0A2R9C6B2
uniprot id: A0A2R9C8Q1
names: Similarity
messages: Belongs to the caprin family.

9597:DDR2
gene id: 9597:DDR2
uniprot id: A0A2R9ADM8
names: Subcellular Location Annotation
messages: Membrane

9597:MYD88
gene id: 9597:MYD88
uniprot id: B3Y679
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
messages: Cytoplasm
messages: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1. Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct. Interacts with OTUD4 deubiquitinase; the interaction is direct.
messages: Nucleus
messages: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
messages: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.

9597:SH3BP5L
gene id: 9597:SH3BP5L
uniprot id: A0A2R9APA4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9597:FUT7
gene id: 9597:FUT7
uniprot id: A0A2R9BCR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9597:DGAT2
gene id: 9597:DGAT2
uniprot id: A0A2R8ZFN0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LPL
gene id: 9597:LPL
uniprot id: A0A2R8ZTC4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9597:TRPM7
gene id: 9597:TRPM7
uniprot id: A0A2R9B3G2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

9597:ADORA3
gene id: 9597:ADORA3
uniprot id: A0A2R9B2Z6
uniprot id: A0A2R9B9K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9597:ADAMTS6
gene id: 9597:ADAMTS6
uniprot id: A0A2R9B0X2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:KCNAB2
gene id: 9597:KCNAB2
uniprot id: A0A2R8ZYL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Membrane
messages: axon
messages: cytoskeleton
messages: synaptosome

9597:LOC100987236
gene id: 9597:LOC100987236
uniprot id: A0A2R8ZJZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

9597:MYORG
gene id: 9597:MYORG
uniprot id: A0A2R8ZJA4
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9597:NF2
gene id: 9597:NF2
uniprot id: A0A2R9AF69
uniprot id: A0A2R9ALW4
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9597:NMBR
gene id: 9597:NMBR
uniprot id: A0A2R9CMF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:PLSCR5
gene id: 9597:PLSCR5
uniprot id: A0A2R9B5H2
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9597:ATAD2
gene id: 9597:ATAD2
uniprot id: A0A2R9CHR1
names: Similarity
messages: Belongs to the AAA ATPase family.

9597:H1-1
gene id: 9597:H1-1
uniprot id: A0A2R8ZJ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9597:RBM8A
gene id: 9597:RBM8A
uniprot id: A0A2R9A8V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9597:SLC2A1
gene id: 9597:SLC2A1
uniprot id: A0A2R9AVB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Membrane
messages: Photoreceptor inner segment

9597:IL3
gene id: 9597:IL3
uniprot id: A0A2R9B411
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-3 family.
messages: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
messages: Secreted

9597:PPCS
gene id: 9597:PPCS
uniprot id: A0A2R9C4I9
names: Similarity
messages: Belongs to the PPC synthetase family.

9597:KHDC4
gene id: 9597:KHDC4
uniprot id: A0A2R9A3L3
names: Similarity
messages: Belongs to the KHDC4 family.

9597:ICAM2
gene id: 9597:ICAM2
uniprot id: A0A2R9B837
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9597:CBS
gene id: 9597:CBS
uniprot id: A0A2R9CEY1
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

9597:LOC106634091
gene id: 9597:LOC106634091
uniprot id: A0A2R8ZPL7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9597:CAMK2A
gene id: 9597:CAMK2A
uniprot id: A0A2R9CAY6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9597:DCN
gene id: 9597:DCN
uniprot id: A0A2R9BU23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

9597:GDF3
gene id: 9597:GDF3
uniprot id: A0A2R9B2U4
names: Similarity
messages: Belongs to the TGF-beta family.

9597:SMG8
gene id: 9597:SMG8
uniprot id: A0A2R9A1Q9
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

9597:NUDT6
gene id: 9597:NUDT6
uniprot id: A0A2R9C965
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Cytoplasm
messages: May contribute to the regulation of cell proliferation.
messages: Mitochondrion
messages: Monomer and homodimer.
messages: Nucleus

9597:CNOT7
gene id: 9597:CNOT7
uniprot id: A0A2R9BER6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9597:EPHB6
gene id: 9597:EPHB6
uniprot id: A0A2R9AQ56
names: Subcellular Location Annotation
messages: Membrane

9597:GBA2
gene id: 9597:GBA2
uniprot id: A0A2R9CAF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

9597:EXOSC8
gene id: 9597:EXOSC8
uniprot id: A0A2R8ZU31
names: Subcellular Location Annotation
messages: Cytoplasm

9597:PHACTR2
gene id: 9597:PHACTR2
uniprot id: A0A2R9C152
uniprot id: A0A2R9C3N9
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9597:BRINP2
gene id: 9597:BRINP2
uniprot id: A0A2R9CIU2
names: Similarity
messages: Belongs to the BRINP family.

9597:SUV39H1
gene id: 9597:SUV39H1
uniprot id: A0A2R9AA50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9597:RIPPLY1
gene id: 9597:RIPPLY1
uniprot id: A0A2R9BR24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9597:LOC100987487
gene id: 9597:LOC100987487
uniprot id: A0A2R9BCR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9597:ACTR2
gene id: 9597:ACTR2
uniprot id: A0A2R9ACM5
uniprot id: A0A2R9AHM0
names: Similarity
messages: Belongs to the actin family.

9597:ZNF267
gene id: 9597:ZNF267
uniprot id: A0A2R9B2J0
uniprot id: A0A2R9B2J4
names: Function
messages: May be involved in transcriptional regulation.

9597:EVA1C
gene id: 9597:EVA1C
uniprot id: A0A2R8ZFC7
names: Similarity
messages: Belongs to the EVA1 family.

9597:PHAF1
gene id: 9597:PHAF1
uniprot id: A0A2R9BNC5
names: Similarity
messages: Belongs to the PHAF1 family.

9597:PPT1
gene id: 9597:PPT1
uniprot id: A0A2R9C1E5
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9597:ATP6V1G3
gene id: 9597:ATP6V1G3
uniprot id: A0A2R9B0Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9597:SDHB
gene id: 9597:SDHB
uniprot id: A0A2R9BCD0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9597:LOC100973697
gene id: 9597:LOC100973697
uniprot id: A0A2R9C8K5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9597:PPIB
gene id: 9597:PPIB
uniprot id: A0A2R9AT23
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9597:ERGIC1
gene id: 9597:ERGIC1
uniprot id: A0A2R9ADL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9597:CBLIF
gene id: 9597:CBLIF
uniprot id: A0A2R9BIS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9597:BNIP1
gene id: 9597:BNIP1
uniprot id: A0A2R9AD20
names: Subcellular Location Annotation
messages: Membrane

9597:DPEP2
gene id: 9597:DPEP2
uniprot id: A0A2R9BIS0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

9597:EXT1
gene id: 9597:EXT1
uniprot id: A0A2R8ZLS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:UTP3
gene id: 9597:UTP3
uniprot id: A0A2R8ZPH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAS10 family.
messages: nucleolus

9597:TXLNA
gene id: 9597:TXLNA
uniprot id: A0A2R8Z7Q5
names: Similarity
messages: Belongs to the taxilin family.

9597:COPG1
gene id: 9597:COPG1
uniprot id: A0A2R8ZYG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9597:ADGRG6
gene id: 9597:ADGRG6
uniprot id: A0A2R9AAU3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:CCDC124
gene id: 9597:CCDC124
uniprot id: A0A2R9AG76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC124 family.
messages: Midbody

9597:LRP1
gene id: 9597:LRP1
uniprot id: A0A2R9A7D0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:THBD
gene id: 9597:THBD
uniprot id: A0A2R8ZHT7
names: Caution
names: Function
names: Subunit
messages: Interacts with ITGAL, ITGAM and ITGB2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

9597:SPSB4
gene id: 9597:SPSB4
uniprot id: A0A2R9AD32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9597:HNMT
gene id: 9597:HNMT
uniprot id: A0A2R9A9L0
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9597:DPAGT1
gene id: 9597:DPAGT1
uniprot id: A0A2R9C1T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:CAPN11
gene id: 9597:CAPN11
uniprot id: A0A2R9BB88
names: Similarity
messages: Belongs to the peptidase C2 family.

9597:ZNF622
gene id: 9597:ZNF622
uniprot id: A0A2R8ZYY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

9597:CD93
gene id: 9597:CD93
uniprot id: A0A2R9BXT9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:GSTO1
gene id: 9597:GSTO1
uniprot id: A0A2R9A5C4
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9597:YJU2B
gene id: 9597:YJU2B
uniprot id: A0A2R9A3W3
names: Similarity
messages: Belongs to the CWC16 family.

9597:KIF17
gene id: 9597:KIF17
uniprot id: A0A2R8ZQV2
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100969266
gene id: 9597:LOC100969266
uniprot id: A0A2R8ZP05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ASB4
gene id: 9597:ASB4
uniprot id: A0A2R9CA43
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:WIF1
gene id: 9597:WIF1
uniprot id: A0A2R9AG94
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:POU4F3
gene id: 9597:POU4F3
uniprot id: A0A2R9CJG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9597:CCND2
gene id: 9597:CCND2
uniprot id: A0A2R9BB92
names: Similarity
messages: Belongs to the cyclin family.

9597:LOC100979321
gene id: 9597:LOC100979321
uniprot id: A0A2R9AA81
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9597:MMP28
gene id: 9597:MMP28
uniprot id: A0A2R9A4I7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9597:LOC100978807
gene id: 9597:LOC100978807
uniprot id: A0A2R8ZTJ7
names: Similarity
messages: Belongs to the LCE family.

9597:NFE2L1
gene id: 9597:NFE2L1
uniprot id: A0A2R9AIZ4
uniprot id: A0A2R9ANQ5
uniprot id: A0A2R9ANQ6
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9597:TNMD
gene id: 9597:TNMD
uniprot id: A0A2R9B8B7
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9597:YPEL4
gene id: 9597:YPEL4
uniprot id: A0A2R9AMH0
names: Similarity
messages: Belongs to the yippee family.

9597:SCD
gene id: 9597:SCD
uniprot id: A0A2R9AD04
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9597:HLCS
gene id: 9597:HLCS
uniprot id: A0A2R9AVQ2
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9597:SLC10A1
gene id: 9597:SLC10A1
uniprot id: A0A2R9AN81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9597:SIAH1
gene id: 9597:SIAH1
uniprot id: A0A2R9AJ65
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9597:IL23A
gene id: 9597:IL23A
uniprot id: A0A2R9CIV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9597:ADIPOR2
gene id: 9597:ADIPOR2
uniprot id: A0A2R9B284
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9597:ZNF613
gene id: 9597:ZNF613
uniprot id: A0A2R9BLW3
names: Function
messages: May be involved in transcriptional regulation.

9597:TET3
gene id: 9597:TET3
uniprot id: A0A2R9AHE4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9597:ITIH2
gene id: 9597:ITIH2
uniprot id: A0A2R8Z603
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9597:OGDHL
gene id: 9597:OGDHL
uniprot id: A0A2R9B524
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9597:CRYBG1
gene id: 9597:CRYBG1
uniprot id: A0A2R9AHZ4
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9597:CCL14
gene id: 9597:CCL14
uniprot id: A0A2R9AZN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:SCML4
gene id: 9597:SCML4
uniprot id: A0A2R8ZIL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9597:EARS2
gene id: 9597:EARS2
uniprot id: A0A2R8ZZ88
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9597:PNKD
gene id: 9597:PNKD
uniprot id: A0A2R9B600
uniprot id: A0A2R9B8M0
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9597:RIPOR2
gene id: 9597:RIPOR2
uniprot id: A0A2R9CLI6
uniprot id: A0A2R9CLL9
names: Similarity
messages: Belongs to the RIPOR family.

9597:ECI1
gene id: 9597:ECI1
uniprot id: A0A2R9BNM9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9597:LOC100973279
gene id: 9597:LOC100973279
uniprot id: A0A2R9CF96
names: Similarity
messages: Belongs to the MIX23 family.

9597:LOC100977832
gene id: 9597:LOC100977832
uniprot id: A0A2R8ZK39
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9597:ATP10B
gene id: 9597:ATP10B
uniprot id: A0A2R9C7A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9597:SNRPE
gene id: 9597:SNRPE
uniprot id: A0A2R9C3U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9597:HTR5A
gene id: 9597:HTR5A
uniprot id: A0A2R9BZG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:VPS4B
gene id: 9597:VPS4B
uniprot id: A0A2R9B0V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9597:LIN7C
gene id: 9597:LIN7C
uniprot id: A0A2R9B2V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9597:SLAIN1
gene id: 9597:SLAIN1
uniprot id: A0A2R9C8M5
uniprot id: A0A2R9C8X7
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9597:SNRPF
gene id: 9597:SNRPF
uniprot id: A0A2R8Z7G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9597:ARL1
gene id: 9597:ARL1
uniprot id: A0A2R9B1F7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9597:KIF22
gene id: 9597:KIF22
uniprot id: A0A2R9ARP3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:TMED4
gene id: 9597:TMED4
uniprot id: A0A2R9B5E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:RPL35
gene id: 9597:RPL35
uniprot id: A0A2R8ZRY3
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9597:ITGB3BP
gene id: 9597:ITGB3BP
uniprot id: A0A2R9AU50
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription coregulator that can have both coactivator and corepressor functions.
messages: centromere
messages: kinetochore

9597:ZNF337
gene id: 9597:ZNF337
uniprot id: A0A2R8ZUC8
names: Function
messages: May be involved in transcriptional regulation.

9597:UBXN1
gene id: 9597:UBXN1
uniprot id: A0A2R9BG52
uniprot id: A0A2R9BKR6
names: Subcellular Location Annotation
messages: Cytoplasm

9597:PAPOLA
gene id: 9597:PAPOLA
uniprot id: A0A2R9AJ48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

9597:CLIC5
gene id: 9597:CLIC5
uniprot id: A0A2R8ZN78
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9597:PRCP
gene id: 9597:PRCP
uniprot id: A0A2R9BCQ3
names: Similarity
messages: Belongs to the peptidase S28 family.

9597:PPIF
gene id: 9597:PPIF
uniprot id: A0A2R9ARV0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9597:B2M
gene id: 9597:B2M
uniprot id: A0A2R8ZGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-2-microglobulin family.
messages: Secreted

9597:KIF21B
gene id: 9597:KIF21B
uniprot id: A0A2R9C367
uniprot id: A0A2R9C5Q4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:UNC5CL
gene id: 9597:UNC5CL
uniprot id: A0A2R9CF24
names: Similarity
messages: Belongs to the unc-5 family.

9597:SEMA3D
gene id: 9597:SEMA3D
uniprot id: A0A2R9BIA1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SLC25A42
gene id: 9597:SLC25A42
uniprot id: A0A2R9BC62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:LOC103782669
gene id: 9597:LOC103782669
uniprot id: A0A2R9BPX7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:HENMT1
gene id: 9597:HENMT1
uniprot id: A0A2R8ZWD2
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9597:PNMT
gene id: 9597:PNMT
uniprot id: A0A2R9ARD0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9597:LOC103784470
gene id: 9597:LOC103784470
uniprot id: A0A2R9ACR5
names: Function
messages: May be involved in transcriptional regulation.

9597:ELL3
gene id: 9597:ELL3
uniprot id: A0A2R8ZSQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9597:SQLE
gene id: 9597:SQLE
uniprot id: A0A2R9CMG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9597:NDUFB3
gene id: 9597:NDUFB3
uniprot id: A0A2R9C357
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9597:PTPA
gene id: 9597:PTPA
uniprot id: A0A2R9CCS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9597:PMVK
gene id: 9597:PMVK
uniprot id: A0A2R9C6W1
names: Subcellular Location Annotation
messages: cytosol

9597:NEDD8
gene id: 9597:NEDD8
uniprot id: A0A2R9BN41
names: Similarity
messages: Belongs to the ubiquitin family.

9597:LOC100986734
gene id: 9597:LOC100986734
uniprot id: A0A2R9AKZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:OPHN1
gene id: 9597:OPHN1
uniprot id: A0A2R8ZJP9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynapse
messages: Presynapse
messages: dendrite

9597:PIGS
gene id: 9597:PIGS
uniprot id: A0A2R9CGJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:SPA17
gene id: 9597:SPA17
uniprot id: A0A2R9BDD1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9597:BEX1
gene id: 9597:BEX1
uniprot id: A0A2R8ZS10
names: Similarity
messages: Belongs to the BEX family.

9597:TSPAN15
gene id: 9597:TSPAN15
uniprot id: A0A2R9C4B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:TBL1XR1
gene id: 9597:TBL1XR1
uniprot id: A0A2R9CPA2
names: Similarity
messages: Belongs to the WD repeat EBI family.

9597:FAM161B
gene id: 9597:FAM161B
uniprot id: A0A2R9BC30
names: Similarity
messages: Belongs to the FAM161 family.

9597:CCL23
gene id: 9597:CCL23
uniprot id: A0A2R9ANS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:PCYT1A
gene id: 9597:PCYT1A
uniprot id: A0A2R9AU96
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9597:FABP1
gene id: 9597:FABP1
uniprot id: A0A2R9B589
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9597:LOC103784296
gene id: 9597:LOC103784296
uniprot id: A0A2R8Z736
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:SLC25A27
gene id: 9597:SLC25A27
uniprot id: A0A2R9A993
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:ATRAID
gene id: 9597:ATRAID
uniprot id: A0A2R9BB35
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:MAF1
gene id: 9597:MAF1
uniprot id: A0A2R9BII4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

9597:OVOL3
gene id: 9597:OVOL3
uniprot id: A0A2R9A5T5
uniprot id: A0A2R9AAK0
names: Subcellular Location Annotation
messages: Nucleus

9597:VIL1
gene id: 9597:VIL1
uniprot id: A0A2R8Z8Z4
names: Similarity
messages: Belongs to the villin/gelsolin family.

9597:EXOC1
gene id: 9597:EXOC1
uniprot id: A0A2R9CKU7
uniprot id: A0A2R9CN68
names: Similarity
messages: Belongs to the SEC3 family.

9597:ADCK5
gene id: 9597:ADCK5
uniprot id: A0A2R9C0F7
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9597:PNCK
gene id: 9597:PNCK
uniprot id: A0A2R9AEK0
uniprot id: A0A2R9AJZ2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:OSBPL8
gene id: 9597:OSBPL8
uniprot id: A0A2R9CL40
names: Similarity
messages: Belongs to the OSBP family.

9597:ZNF74
gene id: 9597:ZNF74
uniprot id: A0A2R9B443
names: Function
messages: May be involved in transcriptional regulation.

9597:NPL
gene id: 9597:NPL
uniprot id: A0A2R9CI64
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Cytoplasm
messages: Homotetramer.

9597:TAS2R60
gene id: 9597:TAS2R60
uniprot id: Q646D0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:TPM1
gene id: 9597:TPM1
uniprot id: A0A2R8Z928
uniprot id: A0A2R8Z970
uniprot id: A0A2R8ZDB4
uniprot id: A0A2R8ZFR5
uniprot id: A0A2R8ZFU2
uniprot id: A0A2R8ZFZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9597:ZER1
gene id: 9597:ZER1
uniprot id: A0A2R9B106
names: Similarity
messages: Belongs to the zyg-11 family.

9597:LOC100973895
gene id: 9597:LOC100973895
uniprot id: A0A2R8ZFI4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:KDM5C
gene id: 9597:KDM5C
uniprot id: A0A2R9BE67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JARID1 histone demethylase family.
messages: Nucleus

9597:COQ3
gene id: 9597:COQ3
uniprot id: A0A2R8ZCE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

9597:DISP3
gene id: 9597:DISP3
uniprot id: A0A2R9BUF0
names: Subcellular Location Annotation
messages: Membrane

9597:DPYSL3
gene id: 9597:DPYSL3
uniprot id: A0A2R9B4M2
uniprot id: A0A2R9B653
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9597:PSMB10
gene id: 9597:PSMB10
uniprot id: A0A2R9AV10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9597:SEPTIN5
gene id: 9597:SEPTIN5
uniprot id: A0A2R9CCR4
uniprot id: A0A2R9CN69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9597:NXPE3
gene id: 9597:NXPE3
uniprot id: A0A2R9B367
names: Similarity
messages: Belongs to the NXPE family.

9597:HDC
gene id: 9597:HDC
uniprot id: A0A2R9BKH8
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9597:DNAJC16
gene id: 9597:DNAJC16
uniprot id: A0A2R9BYW5
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

9597:CNPY2
gene id: 9597:CNPY2
uniprot id: A0A2R9AFI8
names: Similarity
messages: Belongs to the canopy family.

9597:TUBB4A
gene id: 9597:TUBB4A
uniprot id: A0A2R8ZJQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9597:ST8SIA1
gene id: 9597:ST8SIA1
uniprot id: A0A2R9CDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:SLC19A1
gene id: 9597:SLC19A1
uniprot id: A0A2R8ZVI2
uniprot id: A0A2R8ZWP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: Transporter that mediates the import of reduced folates.

9597:LOC100968043
gene id: 9597:LOC100968043
uniprot id: A0A2R9APT6
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:KRT8
gene id: 9597:KRT8
uniprot id: A0A2R9A6T6
names: Similarity
messages: Belongs to the intermediate filament family.

9597:CFAP300
gene id: 9597:CFAP300
uniprot id: A0A2R9BP32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

9597:AQP4
gene id: 9597:AQP4
uniprot id: A0A2R9AJM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9597:EYA3
gene id: 9597:EYA3
uniprot id: A0A2R9BMJ0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9597:NIPA2
gene id: 9597:NIPA2
uniprot id: A0A2R9AFM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9597:CTSD
gene id: 9597:CTSD
uniprot id: A0A2R8ZNM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

9597:DNM3
gene id: 9597:DNM3
uniprot id: A0A2R9AJZ9
uniprot id: A0A2R9ALU9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9597:TMEM106A
gene id: 9597:TMEM106A
uniprot id: A0A2R9B7T8
names: Similarity
messages: Belongs to the TMEM106 family.

9597:TSHZ1
gene id: 9597:TSHZ1
uniprot id: A0A2R9AAC2
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

9597:LOC100972703
gene id: 9597:LOC100972703
uniprot id: A0A2R9C5Z0
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9597:DPEP3
gene id: 9597:DPEP3
uniprot id: A0A2R9AT60
names: Subcellular Location Annotation
messages: Membrane

9597:ETV7
gene id: 9597:ETV7
uniprot id: A0A2R8ZLH3
uniprot id: A0A2R8ZPP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:RPLP1
gene id: 9597:RPLP1
uniprot id: A0A2R9BTM9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9597:WNT8A
gene id: 9597:WNT8A
uniprot id: A0A2R8ZAZ9
uniprot id: A0A2R8ZBG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:MYOZ2
gene id: 9597:MYOZ2
uniprot id: A0A2R9BB68
names: Similarity
messages: Belongs to the myozenin family.

9597:EHD4
gene id: 9597:EHD4
uniprot id: A0A2R9CKA0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9597:SV2B
gene id: 9597:SV2B
uniprot id: A0A2R9A589
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9597:PTK7
gene id: 9597:PTK7
uniprot id: A0A2R9BXV6
names: Subcellular Location Annotation
messages: Membrane

9597:ORMDL2
gene id: 9597:ORMDL2
uniprot id: A0A2R9AYK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9597:DLX4
gene id: 9597:DLX4
uniprot id: A0A2R9C8V4
names: Subcellular Location Annotation
messages: Nucleus

9597:STMN4
gene id: 9597:STMN4
uniprot id: A0A2R9CHU2
uniprot id: A0A2R9CHX5
names: Similarity
messages: Belongs to the stathmin family.

9597:LOC100981854
gene id: 9597:LOC100981854
uniprot id: A0A2R9BBV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.
messages: Nucleus
messages: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening.

9597:PARD6A
gene id: 9597:PARD6A
uniprot id: A0A2R9BT09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9597:STYXL2
gene id: 9597:STYXL2
uniprot id: A0A2R9ADM9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9597:RPF2
gene id: 9597:RPF2
uniprot id: A0A2R9B9K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

9597:ATP5PD
gene id: 9597:ATP5PD
uniprot id: A0A2R9BBD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9597:NRN1L
gene id: 9597:NRN1L
uniprot id: A0A2R9B2T4
names: Similarity
messages: Belongs to the neuritin family.

9597:SLC25A31
gene id: 9597:SLC25A31
uniprot id: A0A2R9A6Y1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9597:NUTM1
gene id: 9597:NUTM1
uniprot id: A0A2R9A006
names: Similarity
messages: Belongs to the NUT family.

9597:CAV2
gene id: 9597:CAV2
uniprot id: A0A2R9CAM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9597:NKAP
gene id: 9597:NKAP
uniprot id: A0A2R9AHB2
names: Similarity
messages: Belongs to the NKAP family.

9597:TMEM161A
gene id: 9597:TMEM161A
uniprot id: A0A2R9CJT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9597:TECR
gene id: 9597:TECR
uniprot id: A0A2R9AIJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:SF3B5
gene id: 9597:SF3B5
uniprot id: A0A2R8ZDC0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9597:ADHFE1
gene id: 9597:ADHFE1
uniprot id: A0A2R9CL72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

9597:CRHR2
gene id: 9597:CRHR2
uniprot id: A0A2R9BTU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

9597:VARS2
gene id: 9597:VARS2
uniprot id: A0A2R9CFL7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:ACER1
gene id: 9597:ACER1
uniprot id: A0A2R9C7X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9597:NPM1
gene id: 9597:NPM1
uniprot id: A0A2R9C8S0
uniprot id: A0A2R9C8S7
names: Similarity
messages: Belongs to the nucleoplasmin family.

9597:DPP4
gene id: 9597:DPP4
uniprot id: A0A2R9CCY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9597:AWAT2
gene id: 9597:AWAT2
uniprot id: A0A2R9BQE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9597:MED8
gene id: 9597:MED8
uniprot id: A0A2R9B3A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:CMAH
gene id: 9597:CMAH
uniprot id: A0A2R9B733
names: Function
names: Similarity
messages: Belongs to the CMP-Neu5Ac hydroxylase family.
messages: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.

9597:TM2D2
gene id: 9597:TM2D2
uniprot id: A0A2R9AYD5
names: Subcellular Location Annotation
messages: Membrane

9597:RPS27
gene id: 9597:RPS27
uniprot id: A0A2R9C9M6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9597:ZNF471
gene id: 9597:ZNF471
uniprot id: A0A2R8Z6X5
names: Function
messages: May be involved in transcriptional regulation.

9597:RAD21L1
gene id: 9597:RAD21L1
uniprot id: A0A2R8ZEV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9597:NDUFB5
gene id: 9597:NDUFB5
uniprot id: A0A2R9ANK1
uniprot id: A0A2R9ANK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:PGM2L1
gene id: 9597:PGM2L1
uniprot id: A0A2R9A9G5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9597:IRX6
gene id: 9597:IRX6
uniprot id: A0A2R8ZGD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9597:PFDN1
gene id: 9597:PFDN1
uniprot id: A0A2R9A886
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9597:LOC100985067
gene id: 9597:LOC100985067
uniprot id: A0A2R9AU08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SCGN
gene id: 9597:SCGN
uniprot id: A0A2R9ANV7
names: Subcellular Location Annotation
messages: secretory vesicle membrane

9597:TOE1
gene id: 9597:TOE1
uniprot id: A0A2R9CR55
names: Similarity
messages: Belongs to the CAF1 family.

9597:TSPAN13
gene id: 9597:TSPAN13
uniprot id: A0A2R8ZDY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:LRRC8A
gene id: 9597:LRRC8A
uniprot id: A0A2R9CN78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9597:MED7
gene id: 9597:MED7
uniprot id: A0A2R8ZSH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9597:ETS1
gene id: 9597:ETS1
uniprot id: A0A2R8ZVE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9597:KIF14
gene id: 9597:KIF14
uniprot id: A0A2R8Z602
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:SLC35B4
gene id: 9597:SLC35B4
uniprot id: A0A2R9BBZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9597:NRP2
gene id: 9597:NRP2
uniprot id: A0A2R9C4B1
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ZFP90
gene id: 9597:ZFP90
uniprot id: A0A2R9B6R8
names: Function
messages: May be involved in transcriptional regulation.

9597:LOC100974973
gene id: 9597:LOC100974973
uniprot id: A0A2R9AQS1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:KMO
gene id: 9597:KMO
uniprot id: A0A2R9ADQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
messages: Mitochondrion outer membrane

9597:LRRC8E
gene id: 9597:LRRC8E
uniprot id: A0A2R9BKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9597:E2F4
gene id: 9597:E2F4
uniprot id: A0A2R8ZB04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9597:ZNF124
gene id: 9597:ZNF124
uniprot id: A0A2R9ATA1
names: Function
messages: May be involved in transcriptional regulation.

9597:SMC1A
gene id: 9597:SMC1A
uniprot id: A0A2R9CBK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9597:C6H6orf89
gene id: 9597:C6H6orf89
uniprot id: A0A2R9CBD6
uniprot id: A0A2R9CDX3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9597:CXCL5
gene id: 9597:CXCL5
uniprot id: A0A2R9B6D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:LOC100980531
gene id: 9597:LOC100980531
uniprot id: A0A2R9A5S2
uniprot id: A0A2R9CBS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:LOC100980803
gene id: 9597:LOC100980803
uniprot id: A0A2R8ZFE4
names: Similarity
messages: Belongs to the ATG8 family.

9597:ZC3HC1
gene id: 9597:ZC3HC1
uniprot id: A0A2R9CQR1
names: Subcellular Location Annotation
messages: Nucleus

9597:RSBN1L
gene id: 9597:RSBN1L
uniprot id: A0A2R9AC68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9597:KAT6B
gene id: 9597:KAT6B
uniprot id: A0A2R8ZD29
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

9597:WARS2
gene id: 9597:WARS2
uniprot id: A0A2R9AVZ7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:RALY
gene id: 9597:RALY
uniprot id: A0A2R9B3Y0
uniprot id: A0A2R9B8X9
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9597:MTFR1
gene id: 9597:MTFR1
uniprot id: A0A2R9ACU4
uniprot id: A0A2R9AHU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9597:GMNN
gene id: 9597:GMNN
uniprot id: A0A2R9C717
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9597:TEKT5
gene id: 9597:TEKT5
uniprot id: A0A2R8ZTC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9597:CTSV
gene id: 9597:CTSV
uniprot id: A0A2R9C6I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9597:TRNT1
gene id: 9597:TRNT1
uniprot id: A0A2R9CS35
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

9597:GRPR
gene id: 9597:GRPR
uniprot id: A0A2R9B7E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:CSAD
gene id: 9597:CSAD
uniprot id: A0A2R9CB49
names: Similarity
messages: Belongs to the group II decarboxylase family.

9597:CDC42BPA
gene id: 9597:CDC42BPA
uniprot id: A0A2R9AEW0
uniprot id: A0A2R9AEW7
uniprot id: A0A2R9AEX3
uniprot id: A0A2R9AFX2
uniprot id: A0A2R9AJS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9597:ASTL
gene id: 9597:ASTL
uniprot id: A0A2R9AP69
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:EMC3
gene id: 9597:EMC3
uniprot id: A0A2R9C5S0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9597:ZFYVE16
gene id: 9597:ZFYVE16
uniprot id: A0A2R9BVI6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9597:RAB33B
gene id: 9597:RAB33B
uniprot id: A0A2R9CHS4
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9597:MSR1
gene id: 9597:MSR1
uniprot id: A0A2R9BBT3
names: Subcellular Location Annotation
messages: Membrane

9597:IDS
gene id: 9597:IDS
uniprot id: A0A2R9BWW8
uniprot id: A0A2R9C0B2
names: Similarity
messages: Belongs to the sulfatase family.

9597:FAM221B
gene id: 9597:FAM221B
uniprot id: A0A2R9AYK1
names: Similarity
messages: Belongs to the FAM221 family.

9597:TAS2R42
gene id: 9597:TAS2R42
uniprot id: A0A2R8ZS79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9597:TAF9B
gene id: 9597:TAF9B
uniprot id: A0A2R9CFB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9597:GRIK3
gene id: 9597:GRIK3
uniprot id: A0A2R9A703
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9597:BRIX1
gene id: 9597:BRIX1
uniprot id: A0A2R9BLW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9597:RRAGD
gene id: 9597:RRAGD
uniprot id: A0A2R9A8P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9597:SLCO1B1
gene id: 9597:SLCO1B1
uniprot id: A0A2R9AN29
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:NEXMIF
gene id: 9597:NEXMIF
uniprot id: A0A2R8ZFQ1
names: Subcellular Location Annotation
messages: Nucleus

9597:ENGASE
gene id: 9597:ENGASE
uniprot id: A0A2R9C2L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

9597:CP
gene id: 9597:CP
uniprot id: A0A2R9AYC2
names: Similarity
messages: Belongs to the multicopper oxidase family.

9597:SLC16A14
gene id: 9597:SLC16A14
uniprot id: A0A2R8ZSF2
names: Subcellular Location Annotation
messages: Membrane

9597:SMC5
gene id: 9597:SMC5
uniprot id: A0A2R8ZBS8
uniprot id: A0A2R8ZFB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

9597:CTPS1
gene id: 9597:CTPS1
uniprot id: A0A2R9A533
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9597:FAM151A
gene id: 9597:FAM151A
uniprot id: A0A2R9A2C3
names: Similarity
messages: Belongs to the FAM151 family.

9597:BLOC1S2
gene id: 9597:BLOC1S2
uniprot id: A0A2R9CI40
uniprot id: A0A2R9CRI6
names: Similarity
messages: Belongs to the BLOC1S2 family.

9597:MIS18A
gene id: 9597:MIS18A
uniprot id: A0A2R8Z6H4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9597:CAB39L
gene id: 9597:CAB39L
uniprot id: A0A2R9A8T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9597:MRPL20
gene id: 9597:MRPL20
uniprot id: A0A2R9CBN9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

9597:RPL14
gene id: 9597:RPL14
uniprot id: A0A2R9A518
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

9597:SLC22A8
gene id: 9597:SLC22A8
uniprot id: A0A2R9C641
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane

9597:BNIP3L
gene id: 9597:BNIP3L
uniprot id: A0A2R9BDM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9597:ALDH3A1
gene id: 9597:ALDH3A1
uniprot id: A0A2R9CHQ4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9597:XPOT
gene id: 9597:XPOT
uniprot id: A0A2R9AGR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9597:CCNB1
gene id: 9597:CCNB1
uniprot id: A0A2R9CK63
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.

9597:ALDOB
gene id: 9597:ALDOB
uniprot id: A0A2R9BPJ9
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9597:LOC100991964
gene id: 9597:LOC100991964
uniprot id: A0A2R8ZL15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:SLCO6A1
gene id: 9597:SLCO6A1
uniprot id: A0A2R8ZPZ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:POU4F2
gene id: 9597:POU4F2
uniprot id: A0A2R9B3T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9597:LOC100988087
gene id: 9597:LOC100988087
uniprot id: A0A2R8Z6Q1
names: Similarity
messages: Belongs to the PRR23 family.

9597:POP4
gene id: 9597:POP4
uniprot id: A0A2R9C2Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9597:LIX1
gene id: 9597:LIX1
uniprot id: A0A2R9B1J2
names: Similarity
messages: Belongs to the LIX1 family.

9597:PEX14
gene id: 9597:PEX14
uniprot id: A0A2R9BLZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
messages: Peroxisome membrane

9597:MRRF
gene id: 9597:MRRF
uniprot id: A0A2R9CH14
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9597:CCDC86
gene id: 9597:CCDC86
uniprot id: A0A2R9CMT4
names: Subcellular Location Annotation
messages: Nucleus

9597:CD38
gene id: 9597:CD38
uniprot id: A0A2R9BE63
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9597:GPD2
gene id: 9597:GPD2
uniprot id: A0A2R9AFW8
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

9597:LOC100982159
gene id: 9597:LOC100982159
uniprot id: A0A2R8ZSL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CACNB2
gene id: 9597:CACNB2
uniprot id: A0A2R9AUD3
uniprot id: A0A2R9AUF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: sarcolemma

9597:HBP1
gene id: 9597:HBP1
uniprot id: A0A2R9CA46
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9597:TGFB1
gene id: 9597:TGFB1
uniprot id: A0A2R9AI79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

9597:NLRP3
gene id: 9597:NLRP3
uniprot id: A0A2R8ZCP5
names: Similarity
messages: Belongs to the NLRP family.

9597:TAS2R8
gene id: 9597:TAS2R8
uniprot id: A0A2R8ZG54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9597:ISCA2
gene id: 9597:ISCA2
uniprot id: A0A2R8ZSR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9597:ALKBH1
gene id: 9597:ALKBH1
uniprot id: A0A2R9C7C9
names: Cofactor
names: Similarity
messages: Belongs to the alkB family.
messages: Binds 1 Fe(2+) ion per subunit.

9597:HMGB1
gene id: 9597:HMGB1
uniprot id: A0A2R9AAV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9597:SLC11A2
gene id: 9597:SLC11A2
uniprot id: A0A2R9BRS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9597:ASB7
gene id: 9597:ASB7
uniprot id: A0A2R9BHT5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:FOXS1
gene id: 9597:FOXS1
uniprot id: A0A2R9ARS5
names: Subcellular Location Annotation
messages: Nucleus

9597:FGFR1
gene id: 9597:FGFR1
uniprot id: A0A2R9AGY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

9597:MDM4
gene id: 9597:MDM4
uniprot id: A0A2R9AGQ3
uniprot id: A0A2R9AHJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

9597:PDCD10
gene id: 9597:PDCD10
uniprot id: A0A2R9AWY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9597:DYNLRB1
gene id: 9597:DYNLRB1
uniprot id: A0A2R9AEC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9597:NR1H3
gene id: 9597:NR1H3
uniprot id: A0A2R9BV37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9597:GLE1
gene id: 9597:GLE1
uniprot id: A0A2R9AY79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

9597:SDR16C5
gene id: 9597:SDR16C5
uniprot id: A0A2R9AMV2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:NKG7
gene id: 9597:NKG7
uniprot id: A0A2R9BSW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9597:CPSF2
gene id: 9597:CPSF2
uniprot id: A0A2R9BVW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9597:GRIA2
gene id: 9597:GRIA2
uniprot id: A0A2R9BL79
uniprot id: A0A2R9BPR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9597:TRMT13
gene id: 9597:TRMT13
uniprot id: A0A2R9CSI6
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9597:GNGT2
gene id: 9597:GNGT2
uniprot id: A0A2R8ZX90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9597:KIF2A
gene id: 9597:KIF2A
uniprot id: A0A2R9AXG0
uniprot id: A0A2R9AXY9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:PF4
gene id: 9597:PF4
uniprot id: A0A2R9BF33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:CDO1
gene id: 9597:CDO1
uniprot id: A0A2R9CIL3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9597:ATAD2B
gene id: 9597:ATAD2B
uniprot id: A0A2R9AS78
names: Similarity
messages: Belongs to the AAA ATPase family.

9597:RHBDL2
gene id: 9597:RHBDL2
uniprot id: A0A2R9C7U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9597:GASK1A
gene id: 9597:GASK1A
uniprot id: A0A2R8ZHQ5
names: Similarity
messages: Belongs to the GASK family.

9597:CKS1B
gene id: 9597:CKS1B
uniprot id: A0A2R9BR08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9597:ZDHHC24
gene id: 9597:ZDHHC24
uniprot id: A0A2R9CQD4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:ABAT
gene id: 9597:ABAT
uniprot id: A0A2R8Z656
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9597:TSPO
gene id: 9597:TSPO
uniprot id: A0A2R8ZE54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9597:CYRIB
gene id: 9597:CYRIB
uniprot id: A0A2R9CCT6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9597:MLH1
gene id: 9597:MLH1
uniprot id: A0A2R9AM85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9597:JPT1
gene id: 9597:JPT1
uniprot id: A0A2R9A552
uniprot id: A0A2R9AAF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9597:LOC100987067
gene id: 9597:LOC100987067
uniprot id: A0A2R9AKJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Odorant receptor.

9597:LOC100969667
gene id: 9597:LOC100969667
uniprot id: A0A2R9ARN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SEMA3G
gene id: 9597:SEMA3G
uniprot id: A0A2R9ASH9
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ZNF558
gene id: 9597:ZNF558
uniprot id: A0A2R9BBF3
names: Function
messages: May be involved in transcriptional regulation.

9597:SLC7A9
gene id: 9597:SLC7A9
uniprot id: A0A2R9C2F7
names: Subcellular Location Annotation
messages: Membrane

9597:POU5F2
gene id: 9597:POU5F2
uniprot id: A0A2R8ZF34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9597:ZNF764
gene id: 9597:ZNF764
uniprot id: A0A2R9ABZ5
names: Function
messages: May be involved in transcriptional regulation.

9597:SMIM15
gene id: 9597:SMIM15
uniprot id: A0A2R8ZNP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9597:JUP
gene id: 9597:JUP
uniprot id: A0A2R9C352
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9597:LOC100990425
gene id: 9597:LOC100990425
uniprot id: A0A2R8ZE65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:PEX19
gene id: 9597:PEX19
uniprot id: A0A2R9BPY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9597:PRKAR1B
gene id: 9597:PRKAR1B
uniprot id: A0A2R9BW82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9597:ZNF627
gene id: 9597:ZNF627
uniprot id: A0A2R9A1Y3
names: Function
messages: May be involved in transcriptional regulation.

9597:RND3
gene id: 9597:RND3
uniprot id: A0A2R9CCZ2
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9597:CD79A
gene id: 9597:CD79A
uniprot id: A0A2R9BXX2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:EIF4G1
gene id: 9597:EIF4G1
uniprot id: A0A2R9CEB6
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9597:CDH5
gene id: 9597:CDH5
uniprot id: A0A2R9B8B3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:RPL39
gene id: 9597:RPL39
uniprot id: A0A2R9CE33
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9597:NCK1
gene id: 9597:NCK1
uniprot id: A0A2R9A1S6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9597:WT1
gene id: 9597:WT1
uniprot id: A0A2R9B171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

9597:TMEM18
gene id: 9597:TMEM18
uniprot id: A0A2R9BTP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM18 family.
messages: Membrane
messages: Nucleus membrane

9597:ADAM17
gene id: 9597:ADAM17
uniprot id: A0A2R9BL62
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:NAP1L1
gene id: 9597:NAP1L1
uniprot id: A0A2R9CHV5
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9597:AGPAT3
gene id: 9597:AGPAT3
uniprot id: A0A2R9AA44
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9597:OLR1
gene id: 9597:OLR1
uniprot id: A0A2R8ZSS2
names: Subcellular Location Annotation
messages: Membrane

9597:POLR2I
gene id: 9597:POLR2I
uniprot id: A0A2R9ATB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9597:CHCHD4
gene id: 9597:CHCHD4
uniprot id: A0A2R9AQL3
uniprot id: A0A2R9AWT2
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

9597:CDC73
gene id: 9597:CDC73
uniprot id: A0A2R9B3T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

9597:CMTM8
gene id: 9597:CMTM8
uniprot id: A0A2R9AGV2
names: Subcellular Location Annotation
messages: Membrane

9597:GK2
gene id: 9597:GK2
uniprot id: A0A2R8ZLZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9597:NDUFAF3
gene id: 9597:NDUFAF3
uniprot id: A0A2R9BLA4
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9597:LOC100983724
gene id: 9597:LOC100983724
uniprot id: A0A2R9APD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TNPO2
gene id: 9597:TNPO2
uniprot id: A0A2R8ZIF0
names: Subcellular Location Annotation
messages: Cytoplasm

9597:NEDD9
gene id: 9597:NEDD9
uniprot id: A0A2R9A1Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9597:DDX6
gene id: 9597:DDX6
uniprot id: A0A2R9B387
names: Similarity
messages: Belongs to the DEAD box helicase family.

9597:PDCL
gene id: 9597:PDCL
uniprot id: A0A2R8ZQ76
names: Similarity
messages: Belongs to the phosducin family.

9597:LHFPL1
gene id: 9597:LHFPL1
uniprot id: A0A2R9B1N4
names: Subcellular Location Annotation
messages: Membrane

9597:OTOG
gene id: 9597:OTOG
uniprot id: A0A2R8ZW83
uniprot id: A0A2R8ZW98
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:MRGPRX3
gene id: 9597:MRGPRX3
uniprot id: A0A2R8ZCA6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:GTF2F2
gene id: 9597:GTF2F2
uniprot id: A0A2R9B7Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9597:CILP
gene id: 9597:CILP
uniprot id: A0A2R9CE12
names: Subcellular Location Annotation
messages: extracellular matrix

9597:KCNMB1
gene id: 9597:KCNMB1
uniprot id: A0A2R9BSK9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9597:ERG
gene id: 9597:ERG
uniprot id: A0A2R9ACP1
uniprot id: A0A2R9ACP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:ODF1
gene id: 9597:ODF1
uniprot id: A0A2R9BJY7
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9597:NOP16
gene id: 9597:NOP16
uniprot id: A0A2R9B8U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9597:ZPR1
gene id: 9597:ZPR1
uniprot id: A0A2R9BCU3
names: Similarity
messages: Belongs to the ZPR1 family.

9597:ACVR1
gene id: 9597:ACVR1
uniprot id: A0A2R9BMX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9597:UBE2T
gene id: 9597:UBE2T
uniprot id: A0A2R9B0J5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:TBCC
gene id: 9597:TBCC
uniprot id: A0A2R8Z8R5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

9597:PEX12
gene id: 9597:PEX12
uniprot id: A0A2R9BAF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.
messages: Membrane
messages: Peroxisome membrane

9597:POLR3F
gene id: 9597:POLR3F
uniprot id: A0A2R9BKK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9597:ZNF284
gene id: 9597:ZNF284
uniprot id: A0A2R9AK22
names: Function
messages: May be involved in transcriptional regulation.

9597:PENK
gene id: 9597:PENK
uniprot id: A0A2R9CRY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

9597:SESN1
gene id: 9597:SESN1
uniprot id: A0A2R9C8E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9597:USP2
gene id: 9597:USP2
uniprot id: A0A2R8ZT66
uniprot id: A0A2R8ZXT1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9597:PIANP
gene id: 9597:PIANP
uniprot id: A0A2R9A3V8
names: Subcellular Location Annotation
messages: Membrane

9597:SULT1C4
gene id: 9597:SULT1C4
uniprot id: A0A2R9BNR2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:IL17A
gene id: 9597:IL17A
uniprot id: A0A2R9A141
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9597:MRPS17
gene id: 9597:MRPS17
uniprot id: A0A2R9BKT7
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9597:GTF2H3
gene id: 9597:GTF2H3
uniprot id: A0A2R9BXP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

9597:LOC100975166
gene id: 9597:LOC100975166
uniprot id: A0A2R9C8K5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9597:SAMD8
gene id: 9597:SAMD8
uniprot id: A0A2R9B5P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9597:LOC100982859
gene id: 9597:LOC100982859
uniprot id: A0A220QK08
names: Similarity
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

9597:WRN
gene id: 9597:WRN
uniprot id: A0A2R9BLV2
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9597:LAMTOR1
gene id: 9597:LAMTOR1
uniprot id: A0A2R9C3K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9597:EIF4A1
gene id: 9597:EIF4A1
uniprot id: A0A2R9C6F8
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9597:CD74
gene id: 9597:CD74
uniprot id: A0A2R9BGX4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ATP6V1E2
gene id: 9597:ATP6V1E2
uniprot id: A0A2R9ARI0
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9597:MCCC2
gene id: 9597:MCCC2
uniprot id: A0A2R9CTB8
names: Similarity
messages: Belongs to the AccD/PCCB family.

9597:TEF
gene id: 9597:TEF
uniprot id: A0A2R9B9E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9597:TIMM9
gene id: 9597:TIMM9
uniprot id: A0A2R9A0P7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9597:SRP68
gene id: 9597:SRP68
uniprot id: A0A2R9A348
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

9597:BUD31
gene id: 9597:BUD31
uniprot id: A0A2R9C277
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9597:INA
gene id: 9597:INA
uniprot id: A0A2R9BN98
names: Similarity
messages: Belongs to the intermediate filament family.

9597:HNRNPK
gene id: 9597:HNRNPK
uniprot id: A0A2R9CSP4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9597:MMUT
gene id: 9597:MMUT
uniprot id: A0A2R9B0C4
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

9597:TMEM88
gene id: 9597:TMEM88
uniprot id: A0A2R9B5I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9597:FMR1
gene id: 9597:FMR1
uniprot id: A0A2R9CAG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Stress granule
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

9597:PHYHIP
gene id: 9597:PHYHIP
uniprot id: A0A2R9A0U4
names: Similarity
messages: Belongs to the PHYHIP family.

9597:DBX2
gene id: 9597:DBX2
uniprot id: A0A2R9BB85
names: Subcellular Location Annotation
messages: Nucleus

9597:UBE2E3
gene id: 9597:UBE2E3
uniprot id: A0A2R9A2H1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:MGAT4D
gene id: 9597:MGAT4D
uniprot id: A0A2R9BC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane

9597:PGAM1
gene id: 9597:PGAM1
uniprot id: A0A2R9A1H4
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9597:PLK2
gene id: 9597:PLK2
uniprot id: A0A2R9BY27
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9597:ATP8B1
gene id: 9597:ATP8B1
uniprot id: A0A2R9CHA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9597:ADAM10
gene id: 9597:ADAM10
uniprot id: A0A2R9C3C4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:GART
gene id: 9597:GART
uniprot id: A0A2R9AA76
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

9597:NUP93
gene id: 9597:NUP93
uniprot id: A0A2R8ZYX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9597:ANO5
gene id: 9597:ANO5
uniprot id: A0A2R9AG47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9597:YWHAZ
gene id: 9597:YWHAZ
uniprot id: A0A2R9BQD0
names: Similarity
messages: Belongs to the 14-3-3 family.

9597:LOC100969317
gene id: 9597:LOC100969317
uniprot id: A0A2R9AMX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TSG101
gene id: 9597:TSG101
uniprot id: A0A2R9AQ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
messages: Membrane

9597:USB1
gene id: 9597:USB1
uniprot id: A0A2R9CAG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9597:NLK
gene id: 9597:NLK
uniprot id: A0A2R9AE67
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9597:SLC25A43
gene id: 9597:SLC25A43
uniprot id: A0A2R9BYG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:ABCC5
gene id: 9597:ABCC5
uniprot id: A0A2R9AB62
names: Subcellular Location Annotation
messages: Membrane

9597:INHA
gene id: 9597:INHA
uniprot id: A0A2R9CFY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9597:TCN1
gene id: 9597:TCN1
uniprot id: A0A2R9CAU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9597:ARRDC3
gene id: 9597:ARRDC3
uniprot id: A0A2R9B0Y9
names: Similarity
messages: Belongs to the arrestin family.

9597:APH1A
gene id: 9597:APH1A
uniprot id: A0A2R9ASX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9597:RPE65
gene id: 9597:RPE65
uniprot id: A0A2R9CDI3
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

9597:ROPN1L
gene id: 9597:ROPN1L
uniprot id: A0A2R9A084
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

9597:SIM1
gene id: 9597:SIM1
uniprot id: A0A2R8ZHR3
names: Subcellular Location Annotation
messages: Nucleus

9597:ZHX1
gene id: 9597:ZHX1
uniprot id: A1YG99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins (By similarity).
messages: Belongs to the ZHX family.
messages: Forms homodimers. Heterodimer (via HD1 domain) with ZHX2 (via HD1 domain). Also forms a heterodimer with ZHX3 which is a prerequisite for repressor activity. Interacts with ATF7IP and NFYA. Interacts (via homeobox domains) with DNMT3B (via PWWP domain) (By similarity).
messages: Nucleus

9597:CCL19
gene id: 9597:CCL19
uniprot id: A0A2R9ARU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:AASDHPPT
gene id: 9597:AASDHPPT
uniprot id: A0A2R9AEU1
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

9597:NOL10
gene id: 9597:NOL10
uniprot id: A0A2R8ZBQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

9597:IZUMO1R
gene id: 9597:IZUMO1R
uniprot id: A0A2R9C5Y0
names: Similarity
messages: Belongs to the folate receptor family.

9597:SLC35C1
gene id: 9597:SLC35C1
uniprot id: A0A2R9BVS0
names: Subcellular Location Annotation
messages: Membrane

9597:DTWD2
gene id: 9597:DTWD2
uniprot id: A0A2R9AVC9
names: Similarity
messages: Belongs to the TDD superfamily. DTWD2 family.

9597:HOXB7
gene id: 9597:HOXB7
uniprot id: A0A2R8ZFM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:LIX1L
gene id: 9597:LIX1L
uniprot id: A0A2R9BTI3
names: Similarity
messages: Belongs to the LIX1 family.

9597:ITIH5
gene id: 9597:ITIH5
uniprot id: A0A2R9CE35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9597:HNF1B
gene id: 9597:HNF1B
uniprot id: A0A2R9C2Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9597:LOC106634670
gene id: 9597:LOC106634670
uniprot id: A0A2R8ZCC0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9597:ZNF41
gene id: 9597:ZNF41
uniprot id: A0A2R9B6G9
names: Function
messages: May be involved in transcriptional regulation.

9597:ZNF649
gene id: 9597:ZNF649
uniprot id: A0A2R8ZSF8
names: Function
messages: May be involved in transcriptional regulation.

9597:CNTNAP2
gene id: 9597:CNTNAP2
uniprot id: A0A2R9A2M7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: paranodal septate junction

9597:DCTN4
gene id: 9597:DCTN4
uniprot id: A0A2R9BKJ4
uniprot id: A0A2R9BQG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: cell cortex
messages: centrosome
messages: sarcomere
messages: stress fiber

9597:VAMP1
gene id: 9597:VAMP1
uniprot id: A0A2R9B198
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9597:SEC13
gene id: 9597:SEC13
uniprot id: A0A2R9CFF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane

9597:ZSCAN26
gene id: 9597:ZSCAN26
uniprot id: A0A2R8ZIE1
names: Subcellular Location Annotation
messages: Nucleus

9597:CRABP1
gene id: 9597:CRABP1
uniprot id: A0A2R8ZL11
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:MAB21L3
gene id: 9597:MAB21L3
uniprot id: A0A2R9BGG0
names: Similarity
messages: Belongs to the mab-21 family.

9597:NHS
gene id: 9597:NHS
uniprot id: A0A2R9AJ71
uniprot id: A0A2R9ARC7
names: Similarity
messages: Belongs to the NHS family.

9597:ZP1
gene id: 9597:ZP1
uniprot id: A0A2R9B9H1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Zona pellucida

9597:NCAPG
gene id: 9597:NCAPG
uniprot id: A0A2R9A1B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9597:BORCS8
gene id: 9597:BORCS8
uniprot id: A0A2R9B0V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

9597:CRIPTO
gene id: 9597:CRIPTO
uniprot id: A0A2R9ACX4
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100971436
gene id: 9597:LOC100971436
uniprot id: A0A2R8ZNF0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9597:LOC100984505
gene id: 9597:LOC100984505
uniprot id: A0A2R8ZTY9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:LOC100977130
gene id: 9597:LOC100977130
uniprot id: A0A2R9B5U7
uniprot id: A0A2R9B8G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9597:SPTAN1
gene id: 9597:SPTAN1
uniprot id: A0A2R9BH53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9597:LOC100978630
gene id: 9597:LOC100978630
uniprot id: A0A2R9BUF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

9597:DUSP4
gene id: 9597:DUSP4
uniprot id: A0A2R9BJD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9597:FGD6
gene id: 9597:FGD6
uniprot id: A0A2R9CI86
names: Subcellular Location Annotation
messages: cytoskeleton

9597:CDKAL1
gene id: 9597:CDKAL1
uniprot id: A0A2R8ZMJ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

9597:IMPA2
gene id: 9597:IMPA2
uniprot id: A0A2R8ZGM8
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9597:SRD5A3
gene id: 9597:SRD5A3
uniprot id: A0A2R9A807
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

9597:MCM7
gene id: 9597:MCM7
uniprot id: A0A2R9B174
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9597:TFRC
gene id: 9597:TFRC
uniprot id: A0A2R8ZIZ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

9597:ZNF184
gene id: 9597:ZNF184
uniprot id: A0A2R9C8X5
names: Function
messages: May be involved in transcriptional regulation.

9597:SF3B6
gene id: 9597:SF3B6
uniprot id: A0A2R9A1Q4
names: Subcellular Location Annotation
messages: Nucleus

9597:TAF13
gene id: 9597:TAF13
uniprot id: A0A2R9BUH2
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100969890
gene id: 9597:LOC100969890
uniprot id: A0A2R9C1A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9597:LOC100970658
gene id: 9597:LOC100970658
uniprot id: A0A2R8ZDB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9597:CAVIN2
gene id: 9597:CAVIN2
uniprot id: A0A2R9C964
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9597:DUXB
gene id: 9597:DUXB
uniprot id: A0A2R9A4N4
names: Subcellular Location Annotation
messages: Nucleus

9597:TLR3
gene id: 9597:TLR3
uniprot id: B3Y621
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9597:TSC22D1
gene id: 9597:TSC22D1
uniprot id: A0A2R9BWG4
uniprot id: A0A2R9BWH4
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9597:MAP2K1
gene id: 9597:MAP2K1
uniprot id: A0A2R9A4U3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:PAMR1
gene id: 9597:PAMR1
uniprot id: A0A2R8ZP49
uniprot id: A0A2R8ZQC7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:QNG1
gene id: 9597:QNG1
uniprot id: A0A2R8ZZH7
names: Function
names: Similarity
messages: Belongs to the QNG1 protein family.
messages: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.

9597:SPTLC2
gene id: 9597:SPTLC2
uniprot id: A0A2R8ZTG0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9597:IL4
gene id: 9597:IL4
uniprot id: A0A2R8ZVJ1
uniprot id: A0A2R8ZXQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
messages: Secreted

9597:CLDN3
gene id: 9597:CLDN3
uniprot id: A0A2R8ZHZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:PIGK
gene id: 9597:PIGK
uniprot id: A0A2R9BWH2
names: Similarity
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.

9597:SCRN1
gene id: 9597:SCRN1
uniprot id: A0A2R8ZIV2
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9597:ZNF45
gene id: 9597:ZNF45
uniprot id: A0A2R8Z888
names: Function
messages: May be involved in transcriptional regulation.

9597:TYMS
gene id: 9597:TYMS
uniprot id: A0A2R9BCN0
names: Similarity
messages: Belongs to the thymidylate synthase family.

9597:RPL9
gene id: 9597:RPL9
uniprot id: A0A2R9CDD2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

9597:DUS4L
gene id: 9597:DUS4L
uniprot id: A0A2R9AM37
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9597:AADACL2
gene id: 9597:AADACL2
uniprot id: A0A2R8ZZ56
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9597:VIM
gene id: 9597:VIM
uniprot id: A0A2R9BXN0
names: Similarity
messages: Belongs to the intermediate filament family.

9597:IGF1
gene id: 9597:IGF1
uniprot id: A0A2R8ZF45
uniprot id: A0A2R8ZF48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9597:TG
gene id: 9597:TG
uniprot id: A0A2R9AW86
names: Caution
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TMBIM1
gene id: 9597:TMBIM1
uniprot id: A0A2R9AYE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9597:ELOVL1
gene id: 9597:ELOVL1
uniprot id: A0A2R9CDD6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9597:AP1M2
gene id: 9597:AP1M2
uniprot id: A0A2R9CDJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9597:PISD
gene id: 9597:PISD
uniprot id: A0A2R9C6P1
uniprot id: A0A2R9CH99
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9597:PSMD5
gene id: 9597:PSMD5
uniprot id: A0A2R9C0K4
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

9597:ATPAF2
gene id: 9597:ATPAF2
uniprot id: A0A2R9AH11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9597:MPC1L
gene id: 9597:MPC1L
uniprot id: A0A2R8ZL99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9597:ZNF684
gene id: 9597:ZNF684
uniprot id: A0A2R9AEE5
names: Function
messages: May be involved in transcriptional regulation.

9597:ILDR1
gene id: 9597:ILDR1
uniprot id: A0A2R9CLH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9597:CASP10
gene id: 9597:CASP10
uniprot id: A0A2R9CBU0
uniprot id: A0A2R9CEB3
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:NFX1
gene id: 9597:NFX1
uniprot id: A0A2R8ZWK3
uniprot id: A0A2R8ZXQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

9597:SCARF1
gene id: 9597:SCARF1
uniprot id: A0A2R9AUW3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:FHL5
gene id: 9597:FHL5
uniprot id: A0A2R9BEN0
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9597:DNAJC25
gene id: 9597:DNAJC25
uniprot id: A0A2R9C1Z6
names: Similarity
messages: Belongs to the DNAJC25 family.

9597:MYO19
gene id: 9597:MYO19
uniprot id: A0A2R9AXU1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:SYS1
gene id: 9597:SYS1
uniprot id: A0A2R9BUQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9597:ST7L
gene id: 9597:ST7L
uniprot id: A0A2R9BHE9
uniprot id: A0A2R9BHF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9597:SLC30A6
gene id: 9597:SLC30A6
uniprot id: A0A2R9BLV1
uniprot id: A0A2R9BV01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9597:FITM1
gene id: 9597:FITM1
uniprot id: A0A2R9ANF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

9597:CA3
gene id: 9597:CA3
uniprot id: A0A2R9CFW9
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9597:CASP7
gene id: 9597:CASP7
uniprot id: A0A2R9BDG5
uniprot id: A0A2R9BHA8
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:DENND5B
gene id: 9597:DENND5B
uniprot id: A0A2R8Z705
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ASPM
gene id: 9597:ASPM
uniprot id: A0A2R9CCV8
uniprot id: A0A2R9CFH3
names: Subcellular Location Annotation
messages: Nucleus
messages: spindle

9597:LOC100978332
gene id: 9597:LOC100978332
uniprot id: A0A2R9AY18
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9597:PPIL6
gene id: 9597:PPIL6
uniprot id: A0A2R9CH22
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9597:STT3A
gene id: 9597:STT3A
uniprot id: A0A2R9BZA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9597:TTC21B
gene id: 9597:TTC21B
uniprot id: A0A2R9BJI3
names: Similarity
messages: Belongs to the TTC21 family.

9597:MFN1
gene id: 9597:MFN1
uniprot id: A0A2R9CKI6
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9597:HOXB6
gene id: 9597:HOXB6
uniprot id: A0A2R9ALG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:MALSU1
gene id: 9597:MALSU1
uniprot id: A0A2R9A9K7
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9597:WSCD2
gene id: 9597:WSCD2
uniprot id: A0A2R9ATF8
names: Function
names: Similarity
messages: Belongs to the WSCD family.
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

9597:SNU13
gene id: 9597:SNU13
uniprot id: A0A2R8ZRL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9597:UTP6
gene id: 9597:UTP6
uniprot id: A0A2R9BKI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

9597:PKN1
gene id: 9597:PKN1
uniprot id: A0A2R9BTG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9597:LOC100973583
gene id: 9597:LOC100973583
uniprot id: A0A2R9BJY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9597:RPS12
gene id: 9597:RPS12
uniprot id: A0A2R9CR19
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9597:PFAS
gene id: 9597:PFAS
uniprot id: A0A2R8ZP75
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

9597:OOSP2
gene id: 9597:OOSP2
uniprot id: A0A2R8ZEK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9597:ERC1
gene id: 9597:ERC1
uniprot id: A0A2R9AZ11
uniprot id: A0A2R9B2T2
names: Subcellular Location Annotation
messages: Cytoplasm

9597:SRPRB
gene id: 9597:SRPRB
uniprot id: A0A2R8ZST4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:SNAP23
gene id: 9597:SNAP23
uniprot id: A0A2R8ZSD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9597:ATF1
gene id: 9597:ATF1
uniprot id: A0A2R9BP84
names: Subcellular Location Annotation
messages: Nucleus

9597:HS3ST2
gene id: 9597:HS3ST2
uniprot id: A0A2R9B8Q8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:RPL36
gene id: 9597:RPL36
uniprot id: A0A2R8ZWN1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

9597:RIC8B
gene id: 9597:RIC8B
uniprot id: A0A2R9AME9
uniprot id: A0A2R9ATV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9597:LYNX1
gene id: 9597:LYNX1
uniprot id: A0A2R9BDR1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:DHX8
gene id: 9597:DHX8
uniprot id: A0A2R9CCJ7
names: Subcellular Location Annotation
messages: Nucleus

9597:HMGCR
gene id: 9597:HMGCR
uniprot id: A0A2R9B572
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

9597:A2M
gene id: 9597:A2M
uniprot id: A0A2R8ZXN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9597:RAD17
gene id: 9597:RAD17
uniprot id: A0A2R9CLE8
uniprot id: A0A2R9CLG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

9597:CAMK1G
gene id: 9597:CAMK1G
uniprot id: A0A2R9CCR5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:DNAJA1
gene id: 9597:DNAJA1
uniprot id: A0A2R8ZXS2
names: Subcellular Location Annotation
messages: Membrane

9597:TRAPPC2B
gene id: 9597:TRAPPC2B
uniprot id: A0A2R9BQ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9597:HOOK1
gene id: 9597:HOOK1
uniprot id: A0A2R9BWC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9597:BLOC1S1
gene id: 9597:BLOC1S1
uniprot id: A0A2R8ZHX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S1 family.
messages: Lysosome membrane
messages: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
messages: Mitochondrion intermembrane space

9597:CCND3
gene id: 9597:CCND3
uniprot id: A0A2R9A185
names: Similarity
messages: Belongs to the cyclin family.

9597:APRT
gene id: 9597:APRT
uniprot id: A0A2R8ZCU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

9597:GPR146
gene id: 9597:GPR146
uniprot id: A0A2R8ZDK9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:BEST1
gene id: 9597:BEST1
uniprot id: A0A2R9A1Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9597:MTMR8
gene id: 9597:MTMR8
uniprot id: A0A2R8ZEM9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9597:HMGB2
gene id: 9597:HMGB2
uniprot id: A0A2R9CNQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9597:IL7R
gene id: 9597:IL7R
uniprot id: A0A2R9BVL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

9597:GNA15
gene id: 9597:GNA15
uniprot id: A0A2R9C5A3
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9597:STX4
gene id: 9597:STX4
uniprot id: A0A2R9AY94
names: Similarity
messages: Belongs to the syntaxin family.

9597:CHEK1
gene id: 9597:CHEK1
uniprot id: A0A2R8ZM27
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9597:CKS2
gene id: 9597:CKS2
uniprot id: A0A2R9CEU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9597:SARDH
gene id: 9597:SARDH
uniprot id: A0A2R8ZS08
names: Similarity
messages: Belongs to the GcvT family.

9597:ARHGEF2
gene id: 9597:ARHGEF2
uniprot id: A0A2R9CGX6
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

9597:DDX24
gene id: 9597:DDX24
uniprot id: A0A2R9BQ89
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9597:DPYD
gene id: 9597:DPYD
uniprot id: A0A2R9C8R4
uniprot id: A0A2R9C8S4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
messages: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

9597:PTCH2
gene id: 9597:PTCH2
uniprot id: A0A2R9ADQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9597:S100A16
gene id: 9597:S100A16
uniprot id: A0A2R9CD60
names: Similarity
messages: Belongs to the S-100 family.

9597:RAD51
gene id: 9597:RAD51
uniprot id: A0A2R9CAJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

9597:EBPL
gene id: 9597:EBPL
uniprot id: A0A2R9CDM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:IL24
gene id: 9597:IL24
uniprot id: A0A2R9BHI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

9597:ASB17
gene id: 9597:ASB17
uniprot id: A0A2R9BZ94
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9597:IST1
gene id: 9597:IST1
uniprot id: A0A2R9CMT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

9597:ACTG1
gene id: 9597:ACTG1
uniprot id: A0A2R9BH44
names: Similarity
messages: Belongs to the actin family.

9597:MMP19
gene id: 9597:MMP19
uniprot id: A0A2R8ZFY2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9597:SIGIRR
gene id: 9597:SIGIRR
uniprot id: A0A2R8ZY42
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9597:GATAD2B
gene id: 9597:GATAD2B
uniprot id: A0A2R9BWZ1
names: Subcellular Location Annotation
messages: Nucleus

9597:SVOPL
gene id: 9597:SVOPL
uniprot id: A0A2R9AAU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9597:TIGD6
gene id: 9597:TIGD6
uniprot id: A0A2R8ZA19
names: Subcellular Location Annotation
messages: Nucleus

9597:CLDN4
gene id: 9597:CLDN4
uniprot id: A0A2R8ZUG6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:ATE1
gene id: 9597:ATE1
uniprot id: A0A2R9BVX0
uniprot id: A0A2R9C5M4
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9597:TMEM59
gene id: 9597:TMEM59
uniprot id: A0A2R9AUU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:CLPTM1
gene id: 9597:CLPTM1
uniprot id: A0A2R9BVV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9597:ZNF354C
gene id: 9597:ZNF354C
uniprot id: A0A2R9C8V9
names: Function
messages: May be involved in transcriptional regulation.

9597:ITK
gene id: 9597:ITK
uniprot id: A0A2R9AHL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9597:DHX9
gene id: 9597:DHX9
uniprot id: A0A2R9AB38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9597:GRIA4
gene id: 9597:GRIA4
uniprot id: A0A2R8ZR77
uniprot id: A0A2R8ZUD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9597:RPS27A
gene id: 9597:RPS27A
uniprot id: A0A2R9B0K9
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

9597:ARPC4
gene id: 9597:ARPC4
uniprot id: A0A2R9AFS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

9597:EMC8
gene id: 9597:EMC8
uniprot id: A0A2R9CBP9
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9597:ZNF850
gene id: 9597:ZNF850
uniprot id: A0A2R9BS37
names: Function
messages: May be involved in transcriptional regulation.

9597:PRKAR2A
gene id: 9597:PRKAR2A
uniprot id: A0A2R9AKR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9597:FREM3
gene id: 9597:FREM3
uniprot id: A0A2R9A5H1
names: Similarity
messages: Belongs to the FRAS1 family.

9597:NDRG1
gene id: 9597:NDRG1
uniprot id: A0A2R8ZLB2
names: Similarity
messages: Belongs to the NDRG family.

9597:CCN5
gene id: 9597:CCN5
uniprot id: A0A2R9BBC6
names: Similarity
messages: Belongs to the CCN family.

9597:RNF5
gene id: 9597:RNF5
uniprot id: A0A2R9BGT5
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

9597:EDNRB
gene id: 9597:EDNRB
uniprot id: A0A2R8ZUY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:HPS5
gene id: 9597:HPS5
uniprot id: A0A2R9BX44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

9597:LOC100989293
gene id: 9597:LOC100989293
uniprot id: A0A2R8ZYG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

9597:DRAM2
gene id: 9597:DRAM2
uniprot id: A0A2R9ATN2
names: Subcellular Location Annotation
messages: Membrane

9597:NUDC
gene id: 9597:NUDC
uniprot id: A0A2R8Z5V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

9597:SEZ6L2
gene id: 9597:SEZ6L2
uniprot id: A0A2R9ALK9
uniprot id: A0A2R9AR31
uniprot id: A0A2R9AR39
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:MYMK
gene id: 9597:MYMK
uniprot id: A0A2R9AL72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9597:CPSF4
gene id: 9597:CPSF4
uniprot id: A0A2R9CR90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9597:PIERCE2
gene id: 9597:PIERCE2
uniprot id: A0A2R9CI54
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9597:MND1
gene id: 9597:MND1
uniprot id: A0A2R9AN51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.

9597:VPS36
gene id: 9597:VPS36
uniprot id: A0A2R8ZFN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

9597:LYZ
gene id: 9597:LYZ
uniprot id: P61627
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
messages: Monomer.
messages: Secreted

9597:IGFBP6
gene id: 9597:IGFBP6
uniprot id: A0A2R9AYI0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:CDKN3
gene id: 9597:CDKN3
uniprot id: A0A2R9CGT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

9597:ADAM32
gene id: 9597:ADAM32
uniprot id: A0A2R9AWU9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:KDELR1
gene id: 9597:KDELR1
uniprot id: A0A2R8ZIU4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:IPO13
gene id: 9597:IPO13
uniprot id: A0A2R9BYS1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

9597:RPLP0
gene id: 9597:RPLP0
uniprot id: A0A2R9AAE7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9597:ATP6V1G1
gene id: 9597:ATP6V1G1
uniprot id: A0A2R8ZA04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9597:TMOD3
gene id: 9597:TMOD3
uniprot id: A0A2R9A378
names: Subcellular Location Annotation
messages: cytoskeleton

9597:FNBP1L
gene id: 9597:FNBP1L
uniprot id: A0A2R9A8H9
uniprot id: A0A2R9A8I9
uniprot id: A0A2R9ADU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9597:ZFP28
gene id: 9597:ZFP28
uniprot id: A0A2R9BYG1
names: Function
messages: May be involved in transcriptional regulation.

9597:GPKOW
gene id: 9597:GPKOW
uniprot id: A0A2R9BYJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus
messages: RNA-binding protein involved in pre-mRNA splicing.

9597:CLCN6
gene id: 9597:CLCN6
uniprot id: A0A2R9BB90
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:HMGCLL1
gene id: 9597:HMGCLL1
uniprot id: A0A2R9ALA9
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

9597:IP6K2
gene id: 9597:IP6K2
uniprot id: A0A2R8ZWR9
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9597:GCNT3
gene id: 9597:GCNT3
uniprot id: A0A2R8ZFN8
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9597:MED4
gene id: 9597:MED4
uniprot id: A0A2R9BPB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:CCK
gene id: 9597:CCK
uniprot id: A0A2R8ZA42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

9597:LOC100975751
gene id: 9597:LOC100975751
uniprot id: A0A2R9CMH2
uniprot id: A0A2R9CP90
uniprot id: A0A2R9CTL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9597:ERCC2
gene id: 9597:ERCC2
uniprot id: A0A2R9CT99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

9597:NTMT1
gene id: 9597:NTMT1
uniprot id: A0A2R9BLQ4
uniprot id: A0A2R9BQA2
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9597:RPL22L1
gene id: 9597:RPL22L1
uniprot id: A0A2R9B3J2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9597:MIEF1
gene id: 9597:MIEF1
uniprot id: A0A2R8ZDM6
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9597:NEIL3
gene id: 9597:NEIL3
uniprot id: A0A2R9BAV7
names: Similarity
messages: Belongs to the FPG family.

9597:MMP27
gene id: 9597:MMP27
uniprot id: A0A2R9AEQ4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9597:RPS6KA3
gene id: 9597:RPS6KA3
uniprot id: A0A2R9AC85
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9597:BMP3
gene id: 9597:BMP3
uniprot id: A0A2R9C6X0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9597:CLNS1A
gene id: 9597:CLNS1A
uniprot id: A0A2R9B7R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9597:SULT2A1
gene id: 9597:SULT2A1
uniprot id: A0A2R9C5R7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:IFT43
gene id: 9597:IFT43
uniprot id: A0A2R9B5V4
names: Similarity
messages: Belongs to the IFT43 family.

9597:VPS28
gene id: 9597:VPS28
uniprot id: A0A2R9CK01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
messages: Membrane

9597:PLA1A
gene id: 9597:PLA1A
uniprot id: A0A2R8ZM37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9597:KCNQ5
gene id: 9597:KCNQ5
uniprot id: A0A2R9C6I5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:TBCCD1
gene id: 9597:TBCCD1
uniprot id: A0A2R9BFH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

9597:BAG6
gene id: 9597:BAG6
uniprot id: A0A2R9A5H6
uniprot id: A0A2R9AA85
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: cytosol
messages: extracellular exosome

9597:LOC100975448
gene id: 9597:LOC100975448
uniprot id: A0A2R8Z7W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SERPINF1
gene id: 9597:SERPINF1
uniprot id: A0A2R9AJQ5
names: Similarity
messages: Belongs to the serpin family.

9597:LOC100990096
gene id: 9597:LOC100990096
uniprot id: A0A2R9B9J3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:FOXM1
gene id: 9597:FOXM1
uniprot id: A0A2R9CHJ6
uniprot id: A0A2R9CKA6
names: Subcellular Location Annotation
messages: Nucleus

9597:TSR2
gene id: 9597:TSR2
uniprot id: A0A2R8ZJG2
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9597:ELL
gene id: 9597:ELL
uniprot id: A0A2R9A3H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9597:NKX2-8
gene id: 9597:NKX2-8
uniprot id: A0A2R9BXM0
names: Subcellular Location Annotation
messages: Nucleus

9597:CD28
gene id: 9597:CD28
uniprot id: A0A2R9B2A1
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100977261
gene id: 9597:LOC100977261
uniprot id: A0A2R8ZKC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:ANAPC5
gene id: 9597:ANAPC5
uniprot id: A0A2R9AX64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9597:ZSCAN22
gene id: 9597:ZSCAN22
uniprot id: A0A2R9AFG9
names: Subcellular Location Annotation
messages: Nucleus

9597:LYAR
gene id: 9597:LYAR
uniprot id: A0A2R9BBE0
names: Subcellular Location Annotation
messages: Cytoplasm

9597:RASSF5
gene id: 9597:RASSF5
uniprot id: A0A2R9A9R2
names: Subcellular Location Annotation
messages: cytoskeleton

9597:SUPV3L1
gene id: 9597:SUPV3L1
uniprot id: A0A2R9B196
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9597:CYP4F12
gene id: 9597:CYP4F12
uniprot id: A0A2R8ZZH0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:ALB
gene id: 9597:ALB
uniprot id: A0A2R9CFC1
names: Subcellular Location Annotation
messages: Secreted

9597:PRPF38B
gene id: 9597:PRPF38B
uniprot id: A0A2R8Z6J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

9597:USP13
gene id: 9597:USP13
uniprot id: A0A2R8ZD09
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9597:SFRP4
gene id: 9597:SFRP4
uniprot id: A0A2R9AVJ4
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:OSBPL1A
gene id: 9597:OSBPL1A
uniprot id: A0A2R8ZXG7
uniprot id: A0A2R8ZXG9
names: Similarity
messages: Belongs to the OSBP family.

9597:ZNF280B
gene id: 9597:ZNF280B
uniprot id: A0A2R9AQT9
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9597:PFN3
gene id: 9597:PFN3
uniprot id: A0A2R8ZI35
names: Similarity
messages: Belongs to the profilin family.

9597:OSBPL6
gene id: 9597:OSBPL6
uniprot id: A0A2R8ZTB4
names: Similarity
messages: Belongs to the OSBP family.

9597:LYPD2
gene id: 9597:LYPD2
uniprot id: A0A2R8ZM16
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:SUSD4
gene id: 9597:SUSD4
uniprot id: A0A2R9AZH6
uniprot id: A0A2R9AZI1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:THBS3
gene id: 9597:THBS3
uniprot id: A0A2R9CM69
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:METTL3
gene id: 9597:METTL3
uniprot id: A0A2R9BRP7
names: Similarity
messages: Belongs to the MT-A70-like family.

9597:PLIN3
gene id: 9597:PLIN3
uniprot id: A0A2R9AEN6
names: Similarity
messages: Belongs to the perilipin family.

9597:FFAR1
gene id: 9597:FFAR1
uniprot id: A0A2R8ZS24
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:EXOC2
gene id: 9597:EXOC2
uniprot id: A0A2R9A9J9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9597:ME1
gene id: 9597:ME1
uniprot id: A0A2R9C9K1
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9597:IGF2
gene id: 9597:IGF2
uniprot id: A0A2R9BAY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Secreted

9597:SCNM1
gene id: 9597:SCNM1
uniprot id: A0A2R9A7C4
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: nucleoplasm

9597:ANKRD34C
gene id: 9597:ANKRD34C
uniprot id: A0A2R8ZCX4
names: Similarity
messages: Belongs to the ANKRD34 family.

9597:DHFR
gene id: 9597:DHFR
uniprot id: A0A2R8ZTA3
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

9597:ASB6
gene id: 9597:ASB6
uniprot id: A0A2R9AIR0
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:FAM72A
gene id: 9597:FAM72A
uniprot id: A0A2R8ZB43
names: Similarity
messages: Belongs to the FAM72 family.

9597:GTPBP8
gene id: 9597:GTPBP8
uniprot id: A0A2R9AQX2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

9597:GNS
gene id: 9597:GNS
uniprot id: A0A2R9AU63
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9597:LOC100973737
gene id: 9597:LOC100973737
uniprot id: A0A2R9BNY3
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9597:TTC39A
gene id: 9597:TTC39A
uniprot id: A0A2R9AH31
names: Similarity
messages: Belongs to the TTC39 family.

9597:TOR1AIP1
gene id: 9597:TOR1AIP1
uniprot id: A0A2R8ZUE1
uniprot id: A0A2R9A022
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9597:FERMT3
gene id: 9597:FERMT3
uniprot id: A0A2R9B3F1
names: Similarity
messages: Belongs to the kindlin family.

9597:GADD45A
gene id: 9597:GADD45A
uniprot id: A0A2R9CAI8
names: Similarity
messages: Belongs to the GADD45 family.

9597:RPF1
gene id: 9597:RPF1
uniprot id: A0A2R9BSD1
names: Subcellular Location Annotation
messages: nucleolus

9597:AVPI1
gene id: 9597:AVPI1
uniprot id: A0A2R9ARR5
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9597:YIPF5
gene id: 9597:YIPF5
uniprot id: A0A2R9C7V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9597:LOC100971082
gene id: 9597:LOC100971082
uniprot id: A0A2R8ZSV3
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9597:SLC45A3
gene id: 9597:SLC45A3
uniprot id: A0A2R9CC87
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100990610
gene id: 9597:LOC100990610
uniprot id: A0A2R9BW25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space
messages: Required for assembly of mitochondrial respiratory chain complexes.

9597:FGFR1OP2
gene id: 9597:FGFR1OP2
uniprot id: A0A2R9AL85
uniprot id: A0A2R9AL94
names: Similarity
messages: Belongs to the SIKE family.

9597:PSMC4
gene id: 9597:PSMC4
uniprot id: A0A2R9AQT0
names: Similarity
messages: Belongs to the AAA ATPase family.

9597:MTCH2
gene id: 9597:MTCH2
uniprot id: A0A2R9CCG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:FGD1
gene id: 9597:FGD1
uniprot id: A0A2R9CM84
names: Subcellular Location Annotation
messages: cytoskeleton

9597:AP2M1
gene id: 9597:AP2M1
uniprot id: A0A2R9B9X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9597:KCND2
gene id: 9597:KCND2
uniprot id: A0A2R9B1Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

9597:LOC100987081
gene id: 9597:LOC100987081
uniprot id: A0A2R9C8E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9597:KDM5B
gene id: 9597:KDM5B
uniprot id: A0A2R9C6D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JARID1 histone demethylase family.
messages: Nucleus

9597:RAPSN
gene id: 9597:RAPSN
uniprot id: A0A2R9CCI0
names: Similarity
messages: Belongs to the RAPsyn family.

9597:ODAM
gene id: 9597:ODAM
uniprot id: A0A2R9AZ39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODAM family.
messages: Cytoplasm
messages: Interacts (via C-terminus) with ARHGEF5.
messages: Nucleus
messages: Secreted
messages: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

9597:OTP
gene id: 9597:OTP
uniprot id: A0A2R9CEY6
names: Subcellular Location Annotation
messages: Nucleus

9597:KHDRBS1
gene id: 9597:KHDRBS1
uniprot id: A0A2R9B8Q7
names: Similarity
messages: Belongs to the KHDRBS family.

9597:ZNF331
gene id: 9597:ZNF331
uniprot id: A0A2R9APT9
names: Function
messages: May be involved in transcriptional regulation.

9597:RPGRIP1L
gene id: 9597:RPGRIP1L
uniprot id: A0A2R9BUT1
uniprot id: A0A2R9BUT8
names: Similarity
messages: Belongs to the RPGRIP1 family.

9597:OS9
gene id: 9597:OS9
uniprot id: A0A2R8ZRP8
uniprot id: A0A2R8ZWD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

9597:RPL8
gene id: 9597:RPL8
uniprot id: A0A2R9C8R8
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9597:C5AR2
gene id: 9597:C5AR2
uniprot id: A0A2R8ZS57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9597:IMPA1
gene id: 9597:IMPA1
uniprot id: A0A2R9AGN2
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9597:CYFIP2
gene id: 9597:CYFIP2
uniprot id: A0A2R9CAR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

9597:P2RY1
gene id: 9597:P2RY1
uniprot id: A0A2R8ZUR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:BGN
gene id: 9597:BGN
uniprot id: A0A2R9AYH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: May be involved in collagen fiber assembly.
messages: extracellular matrix

9597:BMP7
gene id: 9597:BMP7
uniprot id: A0A2R9AT21
names: Similarity
messages: Belongs to the TGF-beta family.

9597:IL17RC
gene id: 9597:IL17RC
uniprot id: A0A2R9C5R4
uniprot id: A0A2R9C5S1
uniprot id: A0A2R9C5S5
uniprot id: A0A2R9C657
names: Subcellular Location Annotation
messages: Membrane

9597:ARHGEF7
gene id: 9597:ARHGEF7
uniprot id: A0A2R8ZTS7
names: Subcellular Location Annotation
messages: lamellipodium

9597:SLC1A2
gene id: 9597:SLC1A2
uniprot id: A0A2R9AD14
uniprot id: A0A2R9AD19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9597:VWC2L
gene id: 9597:VWC2L
uniprot id: A0A2R9BKB5
names: Subcellular Location Annotation
messages: Synapse

9597:SAR1A
gene id: 9597:SAR1A
uniprot id: A0A2R9AMH1
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9597:AXIN2
gene id: 9597:AXIN2
uniprot id: A0A2R9AXL2
names: Subcellular Location Annotation
messages: Cytoplasm

9597:LOC100971665
gene id: 9597:LOC100971665
uniprot id: A0A2R8ZGM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:MTRF1
gene id: 9597:MTRF1
uniprot id: A0A2R8Z5P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9597:LOC100969133
gene id: 9597:LOC100969133
uniprot id: A0A2R9ASC3
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9597:PCYT1B
gene id: 9597:PCYT1B
uniprot id: A0A2R8ZXA1
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9597:CDS1
gene id: 9597:CDS1
uniprot id: A0A2R9CJV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9597:LTBP1
gene id: 9597:LTBP1
uniprot id: A0A2R9BKQ5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:ZNF24
gene id: 9597:ZNF24
uniprot id: A0A2R8ZDP9
names: Subcellular Location Annotation
messages: Nucleus

9597:TBPL2
gene id: 9597:TBPL2
uniprot id: A0A2R9AQ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9597:AATF
gene id: 9597:AATF
uniprot id: A0A2R9C8A1
names: Similarity
messages: Belongs to the AATF family.

9597:COPS7B
gene id: 9597:COPS7B
uniprot id: A0A2R8ZR30
uniprot id: A0A2R8ZR35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9597:SPICE1
gene id: 9597:SPICE1
uniprot id: A0A2R9CKR0
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

9597:TBP
gene id: 9597:TBP
uniprot id: A0A2R9AGJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9597:ATP5IF1
gene id: 9597:ATP5IF1
uniprot id: A0A2R9CQC9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9597:GLIPR1
gene id: 9597:GLIPR1
uniprot id: A0A2R9BRE0
names: Similarity
messages: Belongs to the CRISP family.

9597:NFKB1
gene id: 9597:NFKB1
uniprot id: A0A2R9AKQ2
uniprot id: A0A2R9AST7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:CHAF1B
gene id: 9597:CHAF1B
uniprot id: A0A2R9ACU3
names: Subcellular Location Annotation
messages: Nucleus

9597:RAD9A
gene id: 9597:RAD9A
uniprot id: A0A2R9AJH6
names: Similarity
messages: Belongs to the rad9 family.

9597:DCBLD2
gene id: 9597:DCBLD2
uniprot id: A0A2R9ABR2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LSM7
gene id: 9597:LSM7
uniprot id: A0A2R8ZS01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9597:EML4
gene id: 9597:EML4
uniprot id: A0A2R9B9Y3
uniprot id: A0A2R9BHP8
names: Similarity
messages: Belongs to the WD repeat EMAP family.

9597:KCNK16
gene id: 9597:KCNK16
uniprot id: A0A2R9CJT6
uniprot id: A0A2R9CJU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9597:ZNF677
gene id: 9597:ZNF677
uniprot id: A0A2R9CGP1
names: Function
messages: May be involved in transcriptional regulation.

9597:LOC100978046
gene id: 9597:LOC100978046
uniprot id: A0A2R9ACM3
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9597:MRPL19
gene id: 9597:MRPL19
uniprot id: A0A2R9C8M3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9597:TFIP11
gene id: 9597:TFIP11
uniprot id: A0A2R9BQY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9597:POT1
gene id: 9597:POT1
uniprot id: A0A2R9BKX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9597:SMG5
gene id: 9597:SMG5
uniprot id: A0A2R8ZGF6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

9597:RPL19
gene id: 9597:RPL19
uniprot id: A0A2R9B688
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

9597:AQP3
gene id: 9597:AQP3
uniprot id: A0A2R9CE25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9597:DDB2
gene id: 9597:DDB2
uniprot id: A0A2R8ZA47
names: Subcellular Location Annotation
messages: Nucleus

9597:RRS1
gene id: 9597:RRS1
uniprot id: A0A2R8ZQ17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9597:SCD5
gene id: 9597:SCD5
uniprot id: A0A2R8ZTN7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9597:SYNDIG1
gene id: 9597:SYNDIG1
uniprot id: A0A2R9AD82
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9597:APOOL
gene id: 9597:APOOL
uniprot id: A0A2R9BHR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9597:ESS2
gene id: 9597:ESS2
uniprot id: A0A2R9AXM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9597:MYF5
gene id: 9597:MYF5
uniprot id: A0A2R9A5D4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9597:ATG4D
gene id: 9597:ATG4D
uniprot id: A0A2R9AJ81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9597:TP53RK
gene id: 9597:TP53RK
uniprot id: A0A2R9BNQ8
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

9597:ZNF783
gene id: 9597:ZNF783
uniprot id: A0A2R8ZDR9
names: Function
messages: May be involved in transcriptional regulation.

9597:SLC2A2
gene id: 9597:SLC2A2
uniprot id: A0A2R9BVS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9597:CBR3
gene id: 9597:CBR3
uniprot id: A0A2R8ZEA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9597:OTOP1
gene id: 9597:OTOP1
uniprot id: A0A2R9ADD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9597:LOC100989678
gene id: 9597:LOC100989678
uniprot id: A0A2R8ZPT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:CORO6
gene id: 9597:CORO6
uniprot id: A0A2R8ZIE2
uniprot id: A0A2R8ZKV5
names: Similarity
messages: Belongs to the WD repeat coronin family.

9597:IL13RA2
gene id: 9597:IL13RA2
uniprot id: A0A2R9BPA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.
messages: Membrane

9597:ARPC5
gene id: 9597:ARPC5
uniprot id: A0A2R9BWR3
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9597:DPT
gene id: 9597:DPT
uniprot id: A0A2R8ZEN1
names: Similarity
messages: Belongs to the dermatopontin family.

9597:RNFT1
gene id: 9597:RNFT1
uniprot id: A0A2R9ASA9
names: Subcellular Location Annotation
messages: Membrane

9597:AFM
gene id: 9597:AFM
uniprot id: A0A2R8ZLB9
names: Subcellular Location Annotation
messages: Secreted

9597:HARS2
gene id: 9597:HARS2
uniprot id: A0A2R9BX99
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9597:ST8SIA2
gene id: 9597:ST8SIA2
uniprot id: A0A2R9CF06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:PPARA
gene id: 9597:PPARA
uniprot id: A0A2R9BY52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
messages: Nucleus

9597:CSF1R
gene id: 9597:CSF1R
uniprot id: A0A2R9C866
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9597:ENKUR
gene id: 9597:ENKUR
uniprot id: A0A2R9BA21
names: Subcellular Location Annotation
messages: cilium axoneme

9597:SMIM24
gene id: 9597:SMIM24
uniprot id: A0A2R9C6F6
names: Subcellular Location Annotation
messages: Membrane

9597:PIP4P1
gene id: 9597:PIP4P1
uniprot id: A0A2R9A1B6
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9597:SLC43A3
gene id: 9597:SLC43A3
uniprot id: A0A2R9A1I3
names: Subcellular Location Annotation
messages: Membrane

9597:SDR42E1
gene id: 9597:SDR42E1
uniprot id: A0A2R9AXU6
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9597:ZNF641
gene id: 9597:ZNF641
uniprot id: A0A2R9CKH3
names: Function
messages: May be involved in transcriptional regulation.

9597:ZNF223
gene id: 9597:ZNF223
uniprot id: A0A2R8ZKM0
names: Function
messages: May be involved in transcriptional regulation.

9597:WDFY1
gene id: 9597:WDFY1
uniprot id: A0A2R8ZFX3
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9597:FAM20C
gene id: 9597:FAM20C
uniprot id: A0A2R9C8J1
names: Similarity
messages: Belongs to the FAM20 family.

9597:HDAC1
gene id: 9597:HDAC1
uniprot id: A0A2R9AMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
messages: Nucleus

9597:DTD2
gene id: 9597:DTD2
uniprot id: A0A2R9A540
names: Similarity
messages: Belongs to the DTD family.

9597:GPRC5B
gene id: 9597:GPRC5B
uniprot id: A0A2R8ZYF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:F11R
gene id: 9597:F11R
uniprot id: A0A2R8ZLA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9597:NIFK
gene id: 9597:NIFK
uniprot id: A0A2R9B3P2
names: Subcellular Location Annotation
messages: nucleolus

9597:CLCA2
gene id: 9597:CLCA2
uniprot id: A0A2R9BHZ5
names: Similarity
messages: Belongs to the CLCR family.

9597:PRICKLE3
gene id: 9597:PRICKLE3
uniprot id: A0A2R9C4Z4
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9597:CUL1
gene id: 9597:CUL1
uniprot id: A0A2R9C048
names: Similarity
messages: Belongs to the cullin family.

9597:CETN2
gene id: 9597:CETN2
uniprot id: A0A2R9BTG6
names: Similarity
messages: Belongs to the centrin family.

9597:FABP7
gene id: 9597:FABP7
uniprot id: A0A2R9ABE2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:CHST12
gene id: 9597:CHST12
uniprot id: A0A2R8ZAC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:ALDOA
gene id: 9597:ALDOA
uniprot id: A0A2R9BV84
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9597:GOSR1
gene id: 9597:GOSR1
uniprot id: A0A2R9AEH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9597:TRH
gene id: 9597:TRH
uniprot id: A0A2R9C4N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

9597:RNF31
gene id: 9597:RNF31
uniprot id: A0A2R8ZXR3
names: Similarity
messages: Belongs to the RBR family.

9597:SLC5A7
gene id: 9597:SLC5A7
uniprot id: A0A2R9A7A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9597:AMIGO3
gene id: 9597:AMIGO3
uniprot id: A0A2R8ZE50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9597:CAVIN4
gene id: 9597:CAVIN4
uniprot id: A0A2R9C9Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9597:COG1
gene id: 9597:COG1
uniprot id: A0A2R8ZKL3
names: Similarity
messages: Belongs to the COG1 family.

9597:FYTTD1
gene id: 9597:FYTTD1
uniprot id: A0A2R8ZUI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle
messages: nucleoplasm

9597:TLCD4
gene id: 9597:TLCD4
uniprot id: A0A2R9C637
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100972441
gene id: 9597:LOC100972441
uniprot id: A0A2R9AS38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:FADS3
gene id: 9597:FADS3
uniprot id: A0A2R8ZW45
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:LOC100975275
gene id: 9597:LOC100975275
uniprot id: A0A2R8Z7E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LOC100996206
gene id: 9597:LOC100996206
uniprot id: A0A2R8ZQW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9597:ALDH5A1
gene id: 9597:ALDH5A1
uniprot id: Q3MSM4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion
messages: Redox-regulated. Inhibited under oxydizing conditions (By similarity).

9597:IDI2
gene id: 9597:IDI2
uniprot id: A0A2R9CAI9
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

9597:LOC100986069
gene id: 9597:LOC100986069
uniprot id: A0A2R9AM77
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:UCK1
gene id: 9597:UCK1
uniprot id: A0A2R9CFB1
uniprot id: A0A2R9CHS8
names: Similarity
messages: Belongs to the uridine kinase family.

9597:ZKSCAN3
gene id: 9597:ZKSCAN3
uniprot id: A0A2R9BX51
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:RPL12
gene id: 9597:RPL12
uniprot id: A0A2R9ACW1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9597:NLE1
gene id: 9597:NLE1
uniprot id: A0A2R9AJ97
names: Subcellular Location Annotation
messages: nucleolus

9597:LOC100980635
gene id: 9597:LOC100980635
uniprot id: A0A2R9AH84
names: Similarity
messages: Belongs to the heat shock protein 90 family.

9597:RPL21
gene id: 9597:RPL21
uniprot id: A0A2R8ZJM6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9597:LOXL2
gene id: 9597:LOXL2
uniprot id: A0A2R8ZNC1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9597:RHOT2
gene id: 9597:RHOT2
uniprot id: A0A2R9BIP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9597:PPP2R2A
gene id: 9597:PPP2R2A
uniprot id: A0A2R9B314
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9597:MRPL27
gene id: 9597:MRPL27
uniprot id: A0A2R9BR84
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9597:FUCA1
gene id: 9597:FUCA1
uniprot id: A0A2R9BZA7
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9597:F2
gene id: 9597:F2
uniprot id: A0A2R9C6W7
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

9597:MINDY3
gene id: 9597:MINDY3
uniprot id: A0A2R9CE46
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9597:CCR6
gene id: 9597:CCR6
uniprot id: A0A2R9B7I6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:CDH9
gene id: 9597:CDH9
uniprot id: A0A2R9AV11
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:MRPL10
gene id: 9597:MRPL10
uniprot id: A0A2R9B000
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

9597:ATP5F1B
gene id: 9597:ATP5F1B
uniprot id: A0A2R9BG76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9597:AWAT1
gene id: 9597:AWAT1
uniprot id: A0A2R9CDE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9597:UGT2B4
gene id: 9597:UGT2B4
uniprot id: A0A2R8ZJN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9597:TRAPPC6B
gene id: 9597:TRAPPC6B
uniprot id: A0A2R9C0U9
uniprot id: A0A2R9C3Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9597:SNX14
gene id: 9597:SNX14
uniprot id: A0A2R9BRD1
uniprot id: A0A2R9BUT4
names: Similarity
messages: Belongs to the sorting nexin family.

9597:RAB3C
gene id: 9597:RAB3C
uniprot id: A0A2R8ZB83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9597:CHIA
gene id: 9597:CHIA
uniprot id: A0A2R8ZL98
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9597:TMEM115
gene id: 9597:TMEM115
uniprot id: A0A2R8ZJV2
names: Subcellular Location Annotation
messages: Membrane

9597:TBRG1
gene id: 9597:TBRG1
uniprot id: A0A2R9A871
names: Subcellular Location Annotation
messages: Nucleus

9597:GTPBP4
gene id: 9597:GTPBP4
uniprot id: A0A2R9CCI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9597:HACL1
gene id: 9597:HACL1
uniprot id: A0A2R9CEC8
names: Similarity
messages: Belongs to the TPP enzyme family.

9597:GNPAT
gene id: 9597:GNPAT
uniprot id: A0A2R9CPT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9597:PNPLA4
gene id: 9597:PNPLA4
uniprot id: A0A2R9C601
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CDH11
gene id: 9597:CDH11
uniprot id: A0A2R8ZND1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:STAC
gene id: 9597:STAC
uniprot id: A0A2R9C0J1
names: Subcellular Location Annotation
messages: sarcolemma

9597:LOC100995302
gene id: 9597:LOC100995302
uniprot id: A0A2R9BNY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9597:DNASE2B
gene id: 9597:DNASE2B
uniprot id: A0A2R9AF39
names: Similarity
messages: Belongs to the DNase II family.

9597:FGFR4
gene id: 9597:FGFR4
uniprot id: A0A2R9BFK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9597:AP4B1
gene id: 9597:AP4B1
uniprot id: A0A2R9BMU2
uniprot id: A0A2R9BMW7
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9597:PNN
gene id: 9597:PNN
uniprot id: A0A2R8ZZ35
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pinin family.
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.
messages: Nucleus speckle
messages: desmosome

9597:SCGB2A2
gene id: 9597:SCGB2A2
uniprot id: A0A2R9BRF9
names: Subcellular Location Annotation
messages: Secreted

9597:ORC1
gene id: 9597:ORC1
uniprot id: A0A2R9BD96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus

9597:LOC100976465
gene id: 9597:LOC100976465
uniprot id: P68872
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA).
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

9597:NPR2
gene id: 9597:NPR2
uniprot id: A0A2R9ADF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9597:TMEM175
gene id: 9597:TMEM175
uniprot id: A0A2R8Z6H9
uniprot id: A0A2R8Z6J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

9597:ZNF234
gene id: 9597:ZNF234
uniprot id: A0A2R9AG22
names: Function
messages: May be involved in transcriptional regulation.

9597:ZNF549
gene id: 9597:ZNF549
uniprot id: A0A2R9BS06
names: Function
messages: May be involved in transcriptional regulation.

9597:RNF112
gene id: 9597:RNF112
uniprot id: A0A2R9A1X0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9597:FZD4
gene id: 9597:FZD4
uniprot id: A0A2R9BZZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

9597:ZKSCAN2
gene id: 9597:ZKSCAN2
uniprot id: A0A2R9BG48
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:HCN3
gene id: 9597:HCN3
uniprot id: A0A2R8ZUU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9597:BECN2
gene id: 9597:BECN2
uniprot id: A0A2R8ZFZ4
names: Similarity
messages: Belongs to the beclin family.

9597:LOC100992942
gene id: 9597:LOC100992942
uniprot id: A0A2R8ZLK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:NDUFS5
gene id: 9597:NDUFS5
uniprot id: A0A2R9A979
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9597:TMEM70
gene id: 9597:TMEM70
uniprot id: A0A2R8ZGM5
names: Similarity
messages: Belongs to the TMEM70 family.

9597:HEXIM1
gene id: 9597:HEXIM1
uniprot id: A0A2R8ZEF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9597:SERPINB10
gene id: 9597:SERPINB10
uniprot id: A0A2R9CEW8
names: Similarity
messages: Belongs to the serpin family.

9597:ASRGL1
gene id: 9597:ASRGL1
uniprot id: A0A2R9BKT4
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

9597:RNF8
gene id: 9597:RNF8
uniprot id: A0A2R9AN67
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9597:RRAGB
gene id: 9597:RRAGB
uniprot id: A0A2R9B054
uniprot id: A0A2R9B1D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9597:AMIGO1
gene id: 9597:AMIGO1
uniprot id: A0A2R8ZDX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9597:SKA1
gene id: 9597:SKA1
uniprot id: A0A2R9B3G3
names: Similarity
messages: Belongs to the SKA1 family.

9597:LOC100980458
gene id: 9597:LOC100980458
uniprot id: A0A2R9ALI7
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

9597:HOMER1
gene id: 9597:HOMER1
uniprot id: A0A2R9AR35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9597:P2RY4
gene id: 9597:P2RY4
uniprot id: A0A2R8Z6L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:PLOD1
gene id: 9597:PLOD1
uniprot id: A0A2R9B141
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9597:LOC100974278
gene id: 9597:LOC100974278
uniprot id: A0A2R8ZQW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:AP3M1
gene id: 9597:AP3M1
uniprot id: A0A2R8ZLD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9597:LOC100988698
gene id: 9597:LOC100988698
uniprot id: A0A2R9A9U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9597:AOC2
gene id: 9597:AOC2
uniprot id: A0A2R9CKS0
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9597:ZC3H12A
gene id: 9597:ZC3H12A
uniprot id: A0A2R9CE60
names: Similarity
messages: Belongs to the ZC3H12 family.

9597:CIT
gene id: 9597:CIT
uniprot id: A0A2R9BDB7
uniprot id: A0A2R9BHA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.

9597:XIAP
gene id: 9597:XIAP
uniprot id: A0A2R9A858
names: Similarity
messages: Belongs to the IAP family.

9597:FMNL2
gene id: 9597:FMNL2
uniprot id: A0A2R9BRD6
names: Similarity
messages: Belongs to the formin homology family.

9597:LPIN1
gene id: 9597:LPIN1
uniprot id: A0A2R9ARS1
names: Similarity
messages: Belongs to the lipin family.

9597:HASPIN
gene id: 9597:HASPIN
uniprot id: A0A2R8ZEN4
names: Subcellular Location Annotation
messages: Chromosome

9597:POLR2H
gene id: 9597:POLR2H
uniprot id: A0A2R9BD68
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9597:C5AR1
gene id: 9597:C5AR1
uniprot id: A0A2R8ZT73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9597:SMIM18
gene id: 9597:SMIM18
uniprot id: A0A2R9ARL7
names: Subcellular Location Annotation
messages: Membrane

9597:TMC5
gene id: 9597:TMC5
uniprot id: A0A2R9B896
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9597:IGF2BP3
gene id: 9597:IGF2BP3
uniprot id: A0A2R9AZ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9597:FAM135B
gene id: 9597:FAM135B
uniprot id: A0A2R9C4Q5
names: Similarity
messages: Belongs to the FAM135 family.

9597:PGAP2
gene id: 9597:PGAP2
uniprot id: A0A2R9CF12
uniprot id: A0A2R9CF49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PGAP2 family.
messages: Interacts with PGAP2IP.
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

9597:LOC100968816
gene id: 9597:LOC100968816
uniprot id: A0A2R8ZCS6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:GRHL3
gene id: 9597:GRHL3
uniprot id: A0A2R8ZZ59
names: Subcellular Location Annotation
messages: Nucleus

9597:DCP1A
gene id: 9597:DCP1A
uniprot id: A0A2R9CJ06
uniprot id: A0A2R9CQK4
names: Similarity
messages: Belongs to the DCP1 family.

9597:TAC1
gene id: 9597:TAC1
uniprot id: A0A2R9AR82
uniprot id: A0A2R9AVR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9597:KATNA1
gene id: 9597:KATNA1
uniprot id: A0A2R9CDG2
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

9597:LMOD2
gene id: 9597:LMOD2
uniprot id: A0A2R9B0U2
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9597:LOC103783475
gene id: 9597:LOC103783475
uniprot id: A0A2R8ZPT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:SENP6
gene id: 9597:SENP6
uniprot id: A0A2R9AAE8
uniprot id: A0A2R9AAF0
names: Similarity
messages: Belongs to the peptidase C48 family.

9597:DEDD2
gene id: 9597:DEDD2
uniprot id: A0A2R9CDV1
names: Subcellular Location Annotation
messages: nucleolus

9597:ANAPC2
gene id: 9597:ANAPC2
uniprot id: A0A2R9CGV8
names: Similarity
messages: Belongs to the cullin family.

9597:UBE2S
gene id: 9597:UBE2S
uniprot id: A0A2R9C1F7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:FBL
gene id: 9597:FBL
uniprot id: A0A2R9B441
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9597:TOMM7
gene id: 9597:TOMM7
uniprot id: A0A2R9C848
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:SLF2
gene id: 9597:SLF2
uniprot id: A0A2R9C158
names: Similarity
messages: Belongs to the FAM178 family.

9597:PDP2
gene id: 9597:PDP2
uniprot id: A0A2R8Z6Q8
names: Similarity
messages: Belongs to the PP2C family.

9597:LOC100984072
gene id: 9597:LOC100984072
uniprot id: A0A2R8ZNR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9597:RIDA
gene id: 9597:RIDA
uniprot id: A0A2R9ABI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9597:ARHGDIB
gene id: 9597:ARHGDIB
uniprot id: A0A2R9BGE4
names: Similarity
messages: Belongs to the Rho GDI family.

9597:RHO
gene id: 9597:RHO
uniprot id: A0A2R9C4X0
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore.
messages: Membrane

9597:PMEL
gene id: 9597:PMEL
uniprot id: A0A2R9B1T8
names: Similarity
messages: Belongs to the PMEL/NMB family.

9597:MBOAT4
gene id: 9597:MBOAT4
uniprot id: A0A2R9APM1
names: Subcellular Location Annotation
messages: Membrane

9597:TCN2
gene id: 9597:TCN2
uniprot id: A0A2R9CFW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9597:LOC129392969
gene id: 9597:LOC129392969
uniprot id: A0A2R9AYQ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9597:TLR6
gene id: 9597:TLR6
uniprot id: B3Y642
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:HIKESHI
gene id: 9597:HIKESHI
uniprot id: A0A2R9BH75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9597:SLC66A3
gene id: 9597:SLC66A3
uniprot id: A0A2R8ZUE9
uniprot id: A0A2R8ZX30
names: Subcellular Location Annotation
messages: Membrane

9597:FDPS
gene id: 9597:FDPS
uniprot id: A0A2R8Z608
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9597:RPL26
gene id: 9597:RPL26
uniprot id: A0A2R9CF39
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9597:TMEM106B
gene id: 9597:TMEM106B
uniprot id: A0A2R9ABQ4
names: Similarity
messages: Belongs to the TMEM106 family.

9597:ELK4
gene id: 9597:ELK4
uniprot id: A0A2R9A9R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:ENTPD2
gene id: 9597:ENTPD2
uniprot id: A0A2R9CEE2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9597:APOC4
gene id: 9597:APOC4
uniprot id: A0A2R9CMV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C4 family.
messages: May participate in lipoprotein metabolism.
messages: Secreted

9597:HMBS
gene id: 9597:HMBS
uniprot id: A0A2R8ZI12
names: Similarity
messages: Belongs to the HMBS family.

9597:GPRC6A
gene id: 9597:GPRC6A
uniprot id: A0A2R9APW7
uniprot id: A0A2R9APX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:ZNF174
gene id: 9597:ZNF174
uniprot id: A0A2R9ASF3
names: Subcellular Location Annotation
messages: Nucleus

9597:MYOZ1
gene id: 9597:MYOZ1
uniprot id: A0A2R8ZU40
names: Similarity
messages: Belongs to the myozenin family.

9597:FBP1
gene id: 9597:FBP1
uniprot id: A0A2R9CH13
names: Similarity
messages: Belongs to the FBPase class 1 family.

9597:PLA2G5
gene id: 9597:PLA2G5
uniprot id: A0A2R8ZJJ9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9597:NHSL1
gene id: 9597:NHSL1
uniprot id: A0A2R9BDC9
uniprot id: A0A2R9BEK9
names: Similarity
messages: Belongs to the NHS family.

9597:ZNF689
gene id: 9597:ZNF689
uniprot id: A0A2R9ATC2
names: Function
messages: May be involved in transcriptional regulation.

9597:NXF3
gene id: 9597:NXF3
uniprot id: A0A2R9AJB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

9597:CAND2
gene id: 9597:CAND2
uniprot id: A0A2R8ZEN6
names: Similarity
messages: Belongs to the CAND family.

9597:YPEL5
gene id: 9597:YPEL5
uniprot id: A0A2R9A6P4
names: Similarity
messages: Belongs to the yippee family.

9597:CXCL13
gene id: 9597:CXCL13
uniprot id: A0A2R9BK43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:RPL39L
gene id: 9597:RPL39L
uniprot id: A0A2R8ZAE4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9597:BPGM
gene id: 9597:BPGM
uniprot id: A0A2R9A0W4
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9597:RP2
gene id: 9597:RP2
uniprot id: A0A2R9BVA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9597:POLR2F
gene id: 9597:POLR2F
uniprot id: A0A2R8ZPY5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9597:AGPAT1
gene id: 9597:AGPAT1
uniprot id: A0A2R9BTZ0
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9597:KRBOX4
gene id: 9597:KRBOX4
uniprot id: A0A2R9ABC9
names: Function
messages: May be involved in transcriptional regulation.

9597:PPT2
gene id: 9597:PPT2
uniprot id: A0A2R9CIZ8
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9597:CFI
gene id: 9597:CFI
uniprot id: A0A2R9BVP8
uniprot id: A0A2R9BVQ4
uniprot id: A0A2R9C4V3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:RGS3
gene id: 9597:RGS3
uniprot id: A0A2R9AX77
uniprot id: A0A2R9AX90
names: Subcellular Location Annotation
messages: Cytoplasm

9597:NASP
gene id: 9597:NASP
uniprot id: A0A2R9AQM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

9597:CRYBA2
gene id: 9597:CRYBA2
uniprot id: A0A2R8ZH79
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9597:KAT2A
gene id: 9597:KAT2A
uniprot id: A0A2R9C6Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

9597:LOC100972759
gene id: 9597:LOC100972759
uniprot id: A0A2R8ZD62
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100983779
gene id: 9597:LOC100983779
uniprot id: A0A2R8ZQV3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:LOC100975117
gene id: 9597:LOC100975117
uniprot id: A0A2R8ZHH7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:FCF1
gene id: 9597:FCF1
uniprot id: A0A2R9CBA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9597:ZNF606
gene id: 9597:ZNF606
uniprot id: A0A2R9B9N8
names: Function
messages: May be involved in transcriptional regulation.

9597:MRPS21
gene id: 9597:MRPS21
uniprot id: A0A2R9C9I8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9597:TAS1R1
gene id: 9597:TAS1R1
uniprot id: A0A2R9AFU2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:LDHA
gene id: 9597:LDHA
uniprot id: A0A2R9CIK4
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9597:DLD
gene id: 9597:DLD
uniprot id: A0A2R9AX27
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

9597:GOT1
gene id: 9597:GOT1
uniprot id: A0A2R9CFL4
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9597:ARID3C
gene id: 9597:ARID3C
uniprot id: A0A2R9BT85
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Transcription factor.

9597:EPS8
gene id: 9597:EPS8
uniprot id: A0A2R9BSG7
names: Similarity
messages: Belongs to the EPS8 family.

9597:YPEL3
gene id: 9597:YPEL3
uniprot id: A0A2R9AFN5
names: Similarity
messages: Belongs to the yippee family.

9597:LOC100978707
gene id: 9597:LOC100978707
uniprot id: A0A2R8ZET0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:ZNF225
gene id: 9597:ZNF225
uniprot id: A0A2R9BTQ5
names: Function
messages: May be involved in transcriptional regulation.

9597:TRMT11
gene id: 9597:TRMT11
uniprot id: A0A2R9ABD1
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

9597:RARA
gene id: 9597:RARA
uniprot id: A0A2R9CKZ4
uniprot id: A0A2R9CL03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9597:LOC100975092
gene id: 9597:LOC100975092
uniprot id: A0A2R9C257
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9597:KRT32
gene id: 9597:KRT32
uniprot id: A0A2R8ZEN7
names: Similarity
messages: Belongs to the intermediate filament family.

9597:SENP5
gene id: 9597:SENP5
uniprot id: A0A2R9C5J3
uniprot id: A0A2R9C5X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9597:TMEM214
gene id: 9597:TMEM214
uniprot id: A0A2R8ZCE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:DLST
gene id: 9597:DLST
uniprot id: A0A2R9AG39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9597:DAD1
gene id: 9597:DAD1
uniprot id: A0A2R8ZR60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9597:FERMT2
gene id: 9597:FERMT2
uniprot id: A0A2R9B007
uniprot id: A0A2R9B1Z3
names: Similarity
messages: Belongs to the kindlin family.

9597:LOC100982084
gene id: 9597:LOC100982084
uniprot id: A0A2R8Z858
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:PIK3IP1
gene id: 9597:PIK3IP1
uniprot id: A0A2R9A0C3
uniprot id: A0A2R9A4N9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:BMT2
gene id: 9597:BMT2
uniprot id: A0A2R9ALI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

9597:LSM2
gene id: 9597:LSM2
uniprot id: A0A2R9AS13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

9597:TMEM205
gene id: 9597:TMEM205
uniprot id: A0A2R9BS18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9597:EIPR1
gene id: 9597:EIPR1
uniprot id: A0A2R8ZKR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EIPR1 family.
messages: trans-Golgi network

9597:AKR1D1
gene id: 9597:AKR1D1
uniprot id: A0A2R9CM81
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9597:PIGF
gene id: 9597:PIGF
uniprot id: A0A2R9CCW6
uniprot id: A0A2R9CD35
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:MDH1B
gene id: 9597:MDH1B
uniprot id: A0A2R9AHF3
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9597:PDE6G
gene id: 9597:PDE6G
uniprot id: A0A2R9A364
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9597:CALCB
gene id: 9597:CALCB
uniprot id: A0A2R9BXK8
names: Similarity
messages: Belongs to the calcitonin family.

9597:DDX4
gene id: 9597:DDX4
uniprot id: A0A2R9AVW3
uniprot id: A0A2R9AW64
names: Similarity
messages: Belongs to the DEAD box helicase family.

9597:UCP2
gene id: 9597:UCP2
uniprot id: A0A2R8Z8W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:MMAA
gene id: 9597:MMAA
uniprot id: A0A2R9AIX0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

9597:CHRNB3
gene id: 9597:CHRNB3
uniprot id: A0A2R9BDF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:SLC5A12
gene id: 9597:SLC5A12
uniprot id: A0A2R8ZA67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9597:KCNG4
gene id: 9597:KCNG4
uniprot id: A0A2R9C6G9
names: Subcellular Location Annotation
messages: Membrane

9597:ASF1A
gene id: 9597:ASF1A
uniprot id: A0A2R9BUF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9597:HRH1
gene id: 9597:HRH1
uniprot id: A0A2R8ZS93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:HARS1
gene id: 9597:HARS1
uniprot id: A0A2R9BVQ3
uniprot id: A0A2R9BZ56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

9597:WARS1
gene id: 9597:WARS1
uniprot id: A0A2R9C6X6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:CXCL12
gene id: 9597:CXCL12
uniprot id: A0A2R9C2C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:RPS17
gene id: 9597:RPS17
uniprot id: A0A2R9C0N6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9597:VAMP4
gene id: 9597:VAMP4
uniprot id: A0A2R9A3T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9597:FAM98A
gene id: 9597:FAM98A
uniprot id: A0A2R9BLM0
names: Similarity
messages: Belongs to the FAM98 family.

9597:STAT2
gene id: 9597:STAT2
uniprot id: A0A2R9C943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9597:LOC103782837
gene id: 9597:LOC103782837
uniprot id: A0A2R9CC67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9597:DLK2
gene id: 9597:DLK2
uniprot id: A0A2R8ZUJ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TJP3
gene id: 9597:TJP3
uniprot id: A0A2R9CBY6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9597:EDEM2
gene id: 9597:EDEM2
uniprot id: A0A2R9B6J8
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9597:GABRG2
gene id: 9597:GABRG2
uniprot id: A0A2R9CM58
uniprot id: A0A2R9CM76
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:LOC100973313
gene id: 9597:LOC100973313
uniprot id: A0A2R8ZP55
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:BTG2
gene id: 9597:BTG2
uniprot id: A0A2R8Z9Z8
names: Similarity
messages: Belongs to the BTG family.

9597:CARMIL3
gene id: 9597:CARMIL3
uniprot id: A0A2R9BAR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9597:MST1R
gene id: 9597:MST1R
uniprot id: A0A2R9AIE6
uniprot id: A0A2R9AM93
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:ABCA12
gene id: 9597:ABCA12
uniprot id: A0A2R8ZTD5
names: Subcellular Location Annotation
messages: Membrane

9597:HSF2
gene id: 9597:HSF2
uniprot id: A0A2R9B097
uniprot id: A0A2R9B0A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9597:IDH3A
gene id: 9597:IDH3A
uniprot id: A0A2R9C4H6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9597:B9D1
gene id: 9597:B9D1
uniprot id: A0A2R8ZVX6
names: Subcellular Location Annotation
messages: cilium basal body

9597:EIF3I
gene id: 9597:EIF3I
uniprot id: A0A2R9ADB9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9597:HSDL1
gene id: 9597:HSDL1
uniprot id: A0A2R9C0E3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:RNASE4
gene id: 9597:RNASE4
uniprot id: A0A2R9AR09
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9597:PLA2G12A
gene id: 9597:PLA2G12A
uniprot id: A0A2R9A9H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9597:AP1G1
gene id: 9597:AP1G1
uniprot id: A0A2R9AGR9
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9597:ADCK1
gene id: 9597:ADCK1
uniprot id: A0A2R9CLS1
uniprot id: A0A2R9CT82
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9597:DGKB
gene id: 9597:DGKB
uniprot id: A0A2R9BCL3
uniprot id: A0A2R9BEZ0
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9597:LAMA4
gene id: 9597:LAMA4
uniprot id: A0A2R9C435
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9597:MED6
gene id: 9597:MED6
uniprot id: A0A2R9CA51
uniprot id: A0A2R9CAC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9597:C5H5orf24
gene id: 9597:C5H5orf24
uniprot id: A0A2R9CPD9
names: Similarity
messages: Belongs to the UPF0461 family.

9597:KDR
gene id: 9597:KDR
uniprot id: A0A2R9CED2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9597:ENO3
gene id: 9597:ENO3
uniprot id: A0A2R9C630
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9597:PTAFR
gene id: 9597:PTAFR
uniprot id: A0A2R8ZQA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

9597:RAP1GDS1
gene id: 9597:RAP1GDS1
uniprot id: A0A2R9AA08
uniprot id: A0A2R9AA23
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion

9597:EIF6
gene id: 9597:EIF6
uniprot id: A0A2R9ADA3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9597:LOC100982199
gene id: 9597:LOC100982199
uniprot id: A0A2R8ZN48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:DUSP7
gene id: 9597:DUSP7
uniprot id: A0A2R9CJY9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9597:RO60
gene id: 9597:RO60
uniprot id: A0A2R9CN56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

9597:NNT
gene id: 9597:NNT
uniprot id: A0A2R8ZD06
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9597:UNC13B
gene id: 9597:UNC13B
uniprot id: A0A2R9BH08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-13 family.
messages: Cytoplasm
messages: Membrane

9597:CSE1L
gene id: 9597:CSE1L
uniprot id: A0A2R9BNT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9597:IL1RAP
gene id: 9597:IL1RAP
uniprot id: A0A2R8ZEL5
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9597:PSMA8
gene id: 9597:PSMA8
uniprot id: A0A2R8ZX05
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9597:LOC100976704
gene id: 9597:LOC100976704
uniprot id: A0A2R9BLT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9597:CRY2
gene id: 9597:CRY2
uniprot id: A0A2R9AVA7
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

9597:DNTT
gene id: 9597:DNTT
uniprot id: A0A2R9C288
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.

9597:SLC24A1
gene id: 9597:SLC24A1
uniprot id: A0A2R9CF90
uniprot id: A0A2R9CFC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9597:DNTTIP1
gene id: 9597:DNTTIP1
uniprot id: A0A2R8ZVI0
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100980195
gene id: 9597:LOC100980195
uniprot id: A0A2R8ZJC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:FAM3C
gene id: 9597:FAM3C
uniprot id: A0A2R9BJ58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9597:HSPA4
gene id: 9597:HSPA4
uniprot id: A0A2R9C712
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9597:KRT76
gene id: 9597:KRT76
uniprot id: A0A2R9C9C9
names: Similarity
messages: Belongs to the intermediate filament family.

9597:RRP1
gene id: 9597:RRP1
uniprot id: A0A2R9A8G5
names: Similarity
messages: Belongs to the RRP1 family.

9597:GPR87
gene id: 9597:GPR87
uniprot id: A0A2R9BZI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:E2F8
gene id: 9597:E2F8
uniprot id: A0A2R9B864
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9597:ZFYVE27
gene id: 9597:ZFYVE27
uniprot id: A0A2R9A4L5
uniprot id: A0A2R9A5R8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

9597:COPB1
gene id: 9597:COPB1
uniprot id: A0A2R9BT66
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9597:NOP14
gene id: 9597:NOP14
uniprot id: A0A2R9BLU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

9597:TGFB1I1
gene id: 9597:TGFB1I1
uniprot id: A0A2R9BBV8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.
messages: Nucleus matrix
messages: The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.
messages: cytoskeleton
messages: focal adhesion

9597:OXA1L
gene id: 9597:OXA1L
uniprot id: A0A2R9AX51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9597:LRRFIP2
gene id: 9597:LRRFIP2
uniprot id: A0A2R9BSQ3
names: Similarity
messages: Belongs to the LRRFIP family.

9597:ETFRF1
gene id: 9597:ETFRF1
uniprot id: A0A2R9BVR7
names: Similarity
messages: Belongs to the complex I LYR family.

9597:MYO1B
gene id: 9597:MYO1B
uniprot id: A0A2R9BYI9
uniprot id: A0A2R9C4U5
uniprot id: A0A2R9C4V0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:PPP4R3C
gene id: 9597:PPP4R3C
uniprot id: A0A2R8ZAF7
names: Similarity
messages: Belongs to the SMEK family.

9597:GPR180
gene id: 9597:GPR180
uniprot id: A0A2R9C6S9
names: Subcellular Location Annotation
messages: Membrane

9597:ENY2
gene id: 9597:ENY2
uniprot id: A0A2R9CM41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9597:NR0B1
gene id: 9597:NR0B1
uniprot id: A0A2R8ZNT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9597:CPT1B
gene id: 9597:CPT1B
uniprot id: A0A2R8ZN01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:ADAM15
gene id: 9597:ADAM15
uniprot id: A0A2R9BLW5
uniprot id: A0A2R9BLW9
uniprot id: A0A2R9BM08
uniprot id: A0A2R9BMT1
uniprot id: A0A2R9BVZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SCAMP5
gene id: 9597:SCAMP5
uniprot id: A0A2R9CE85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9597:HOXC6
gene id: 9597:HOXC6
uniprot id: A0A2R9BDQ6
names: Subcellular Location Annotation
messages: Nucleus

9597:ENPP2
gene id: 9597:ENPP2
uniprot id: A0A2R9AJU3
uniprot id: A0A2R9AJU7
uniprot id: A0A2R9APG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9597:MRPS7
gene id: 9597:MRPS7
uniprot id: A0A2R8ZN53
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9597:LOC100976375
gene id: 9597:LOC100976375
uniprot id: A0A2R8ZVA2
names: Similarity
messages: Belongs to the PRAME family.

9597:PTMA
gene id: 9597:PTMA
uniprot id: A0A2R9CFU6
names: Similarity
messages: Belongs to the pro/parathymosin family.

9597:LOC100977815
gene id: 9597:LOC100977815
uniprot id: A0A2R8ZCK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:EGR1
gene id: 9597:EGR1
uniprot id: A0A2R9A849
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9597:LOC100990846
gene id: 9597:LOC100990846
uniprot id: A0A2R8ZNX0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:SNRPD3
gene id: 9597:SNRPD3
uniprot id: A0A2R9C1Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9597:KCNE1
gene id: 9597:KCNE1
uniprot id: A0A2R8ZIR2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the potassium channel KCNE family.
messages: Cell membrane
messages: Membrane

9597:CACNG2
gene id: 9597:CACNG2
uniprot id: A0A2R8ZR06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

9597:CIAPIN1
gene id: 9597:CIAPIN1
uniprot id: A0A2R9C840
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

9597:LOC100995405
gene id: 9597:LOC100995405
uniprot id: A0A2R8ZF24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:MVK
gene id: 9597:MVK
uniprot id: A0A2R9CMF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
messages: Cytoplasm

9597:ESRRG
gene id: 9597:ESRRG
uniprot id: A0A2R9B322
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9597:ELOA
gene id: 9597:ELOA
uniprot id: A0A2R8Z8S5
names: Subcellular Location Annotation
messages: Nucleus

9597:CRCP
gene id: 9597:CRCP
uniprot id: A0A2R9AB98
uniprot id: A0A2R9ACB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9597:ZNF586
gene id: 9597:ZNF586
uniprot id: A0A2R8ZUY7
uniprot id: A0A2R8ZW53
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:EYA2
gene id: 9597:EYA2
uniprot id: A0A2R9BSL8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9597:EFTUD2
gene id: 9597:EFTUD2
uniprot id: A0A2R9AB34
names: Subcellular Location Annotation
messages: Nucleus

9597:HMGN2
gene id: 9597:HMGN2
uniprot id: A0A2R9AT03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9597:SLC1A3
gene id: 9597:SLC1A3
uniprot id: A0A2R9AQ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9597:EIF2D
gene id: 9597:EIF2D
uniprot id: A0A2R9AWK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

9597:LOC100991849
gene id: 9597:LOC100991849
uniprot id: A0A2R9BWP9
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9597:TSPAN9
gene id: 9597:TSPAN9
uniprot id: A0A2R9AZD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:OGFOD1
gene id: 9597:OGFOD1
uniprot id: A0A2R9AE79
names: Similarity
messages: Belongs to the TPA1 family.

9597:CANX
gene id: 9597:CANX
uniprot id: A0A2R9AWV7
names: Similarity
messages: Belongs to the calreticulin family.

9597:PPP2R5A
gene id: 9597:PPP2R5A
uniprot id: A0A2R8ZLU4
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9597:CTSO
gene id: 9597:CTSO
uniprot id: A0A2R9CA02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9597:RAB21
gene id: 9597:RAB21
uniprot id: A0A2R9CLV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: trans-Golgi network

9597:COPS7A
gene id: 9597:COPS7A
uniprot id: A0A2R8ZKI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9597:MASP1
gene id: 9597:MASP1
uniprot id: A0A2R9BDE3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CBLB
gene id: 9597:CBLB
uniprot id: A0A2R9AMN4
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9597:HS6ST2
gene id: 9597:HS6ST2
uniprot id: A0A2R9AKB0
uniprot id: A0A2R9AL13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

9597:TPMT
gene id: 9597:TPMT
uniprot id: A0A2R9A781
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Monomer.

9597:ODF2
gene id: 9597:ODF2
uniprot id: A0A2R9ARA0
uniprot id: A0A2R9AVZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9597:RBCK1
gene id: 9597:RBCK1
uniprot id: A0A2R9ARJ5
names: Similarity
messages: Belongs to the RBR family.

9597:BRCA1
gene id: 9597:BRCA1
uniprot id: A0A075VQZ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.
messages: Nucleus

9597:ICAM1
gene id: 9597:ICAM1
uniprot id: Q5NKV4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Homodimer. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells.
messages: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).
messages: Membrane
messages: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

9597:CHMP2B
gene id: 9597:CHMP2B
uniprot id: A0A2R9ARV3
names: Similarity
messages: Belongs to the SNF7 family.

9597:EGFL7
gene id: 9597:EGFL7
uniprot id: A0A2R9BNP8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ZNF274
gene id: 9597:ZNF274
uniprot id: A0A2R9AMB7
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:PTGFR
gene id: 9597:PTGFR
uniprot id: A0A2R9B3G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:RLN2
gene id: 9597:RLN2
uniprot id: A0A2R8ZRM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
messages: Secreted

9597:LSS
gene id: 9597:LSS
uniprot id: A0A2R9B2H2
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

9597:SHMT2
gene id: 9597:SHMT2
uniprot id: A0A2R9AVY3
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9597:SUPT5H
gene id: 9597:SUPT5H
uniprot id: A0A2R9C9U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9597:AGPAT4
gene id: 9597:AGPAT4
uniprot id: A0A2R9CBN8
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9597:CSMD3
gene id: 9597:CSMD3
uniprot id: A0A2R9C8Y9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:WDR76
gene id: 9597:WDR76
uniprot id: A0A2R8ZMQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9597:FAAH
gene id: 9597:FAAH
uniprot id: A0A2R9AN18
names: Similarity
messages: Belongs to the amidase family.

9597:LOC100992664
gene id: 9597:LOC100992664
uniprot id: A0A2R8ZPV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SPX
gene id: 9597:SPX
uniprot id: A0A2R9A851
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

9597:BICD1
gene id: 9597:BICD1
uniprot id: A0A2R9C2W7
uniprot id: A0A2R9C2W9
uniprot id: A0A2R9C2X1
names: Similarity
messages: Belongs to the BicD family.

9597:PTPN6
gene id: 9597:PTPN6
uniprot id: A0A2R8ZVQ8
uniprot id: A0A2R8ZWV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9597:IL12A
gene id: 9597:IL12A
uniprot id: A0A2R9BQY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.
messages: Secreted

9597:BARHL2
gene id: 9597:BARHL2
uniprot id: A0A2R9B1X9
names: Subcellular Location Annotation
messages: Nucleus

9597:NXF1
gene id: 9597:NXF1
uniprot id: A0A2R9C974
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9597:NEK7
gene id: 9597:NEK7
uniprot id: A0A2R9A9G9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:YAF2
gene id: 9597:YAF2
uniprot id: A0A2R9AZB3
uniprot id: A0A2R9B1A0
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100974797
gene id: 9597:LOC100974797
uniprot id: A0A2R8ZDX8
names: Similarity
messages: Belongs to the GAGE family.

9597:GALNT15
gene id: 9597:GALNT15
uniprot id: A0A2R9C5X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9597:PGAP1
gene id: 9597:PGAP1
uniprot id: A0A2R9BTW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9597:ZDHHC5
gene id: 9597:ZDHHC5
uniprot id: A0A2R9BMP4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:BTG3
gene id: 9597:BTG3
uniprot id: A0A2R9CEI1
names: Similarity
messages: Belongs to the BTG family.

9597:KPNA1
gene id: 9597:KPNA1
uniprot id: A0A2R9BX67
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9597:SGSM2
gene id: 9597:SGSM2
uniprot id: A0A2R9BQQ1
uniprot id: A0A2R9BZT2
names: Similarity
messages: Belongs to the RUTBC family.

9597:LOC100988794
gene id: 9597:LOC100988794
uniprot id: A0A2R8ZEZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SMARCA1
gene id: 9597:SMARCA1
uniprot id: A0A2R9B0H8
uniprot id: A0A2R9B6Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9597:LEF1
gene id: 9597:LEF1
uniprot id: A0A2R9CF20
uniprot id: A0A2R9CPR7
uniprot id: A0A2R9CPR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9597:LDOC1
gene id: 9597:LDOC1
uniprot id: Q6SEH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDOC1 family.
messages: Interacts with NOD2.
messages: May have an important role in the development and/or progression of some cancers.
messages: Nucleus

9597:CFAP157
gene id: 9597:CFAP157
uniprot id: A0A2R9BUB0
names: Similarity
messages: Belongs to the CFAP157 family.

9597:POLR2M
gene id: 9597:POLR2M
uniprot id: A0A2R8Z958
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

9597:ZDHHC13
gene id: 9597:ZDHHC13
uniprot id: A0A2R9CM25
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:PPP4C
gene id: 9597:PPP4C
uniprot id: A0A2R9AX24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9597:PPIA
gene id: 9597:PPIA
uniprot id: A0A286QUP5
uniprot id: Q0ZQL2
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).
messages: Cytoplasm
messages: Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: Secreted

9597:EWSR1
gene id: 9597:EWSR1
uniprot id: A0A2R9ARH0
uniprot id: A0A2R9AXK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9597:VEZT
gene id: 9597:VEZT
uniprot id: A0A2R9ASA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9597:MED9
gene id: 9597:MED9
uniprot id: A0A2R9CSE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:LOC100979729
gene id: 9597:LOC100979729
uniprot id: A0A2R8ZBG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:FOXP2
gene id: 9597:FOXP2
uniprot id: Q8HZ00
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity). Interacts with FOXP1 (By similarity). Interacts with TBR1 (By similarity). Interacts with ZMYM2 (By similarity).
messages: Nucleus
messages: The leucine-zipper is required for dimerization and transcriptional repression.
messages: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity).

9597:ARPIN
gene id: 9597:ARPIN
uniprot id: A0A2R9C3M6
names: Similarity
messages: Belongs to the Arpin family.

9597:ADK
gene id: 9597:ADK
uniprot id: A0A2R9ARG8
uniprot id: A0A2R9AY42
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9597:MLF2
gene id: 9597:MLF2
uniprot id: A0A2R9B1C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9597:CCN4
gene id: 9597:CCN4
uniprot id: A0A2R9CCT8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:KRT82
gene id: 9597:KRT82
uniprot id: A0A2R9AZX5
names: Similarity
messages: Belongs to the intermediate filament family.

9597:GAL3ST1
gene id: 9597:GAL3ST1
uniprot id: A0A2R9B778
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9597:DLX3
gene id: 9597:DLX3
uniprot id: A0A2R8Z7N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9597:BAZ2A
gene id: 9597:BAZ2A
uniprot id: A0A2R8ZBN1
uniprot id: A0A2R8ZBP4
names: Similarity
messages: Belongs to the WAL family.

9597:LCMT1
gene id: 9597:LCMT1
uniprot id: A0A2R9A988
uniprot id: A0A2R9AD96
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9597:CMTM6
gene id: 9597:CMTM6
uniprot id: A0A2R9B108
names: Subcellular Location Annotation
messages: Membrane

9597:RARB
gene id: 9597:RARB
uniprot id: A0A2R9BQB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9597:SLC29A1
gene id: 9597:SLC29A1
uniprot id: A0A2R9AV25
uniprot id: A0A2R9B164
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

9597:LOC100982707
gene id: 9597:LOC100982707
uniprot id: A0A2R9AR78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:KIAA1191
gene id: 9597:KIAA1191
uniprot id: A0A2R8ZMV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9597:GJB6
gene id: 9597:GJB6
uniprot id: A0A2R8ZJN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:POLR3K
gene id: 9597:POLR3K
uniprot id: A0A2R9BVX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9597:PIERCE1
gene id: 9597:PIERCE1
uniprot id: A0A2R8ZDG2
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9597:ADGRG3
gene id: 9597:ADGRG3
uniprot id: A0A2R9BJ79
names: Subcellular Location Annotation
messages: Membrane

9597:CAMSAP2
gene id: 9597:CAMSAP2
uniprot id: A0A2R8ZV42
uniprot id: A0A2R8ZWB3
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9597:CASQ1
gene id: 9597:CASQ1
uniprot id: A0A2R9AKL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9597:CDC14A
gene id: 9597:CDC14A
uniprot id: A0A2R9A7W1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9597:PGBD1
gene id: 9597:PGBD1
uniprot id: A0A2R9BPD9
names: Subcellular Location Annotation
messages: Nucleus

9597:CKMT2
gene id: 9597:CKMT2
uniprot id: A0A2R9C757
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9597:PCK2
gene id: 9597:PCK2
uniprot id: A0A2R9AWJ1
names: Similarity
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Monomer.

9597:FXYD7
gene id: 9597:FXYD7
uniprot id: A0A2R8ZYP9
names: Similarity
messages: Belongs to the FXYD family.

9597:NCLN
gene id: 9597:NCLN
uniprot id: A0A2R9CIF4
names: Function
names: Similarity
messages: Belongs to the nicastrin family.
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

9597:ELF1
gene id: 9597:ELF1
uniprot id: A0A2R9AQQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:CFL1
gene id: 9597:CFL1
uniprot id: A0A2R9C8K4
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9597:SPG7
gene id: 9597:SPG7
uniprot id: A0A2R9AEG9
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9597:LOC100994379
gene id: 9597:LOC100994379
uniprot id: A0A2R8ZHK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ADCY9
gene id: 9597:ADCY9
uniprot id: A0A2R8ZJ01
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9597:DARS1
gene id: 9597:DARS1
uniprot id: A0A2R9BVT7
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

9597:OAT
gene id: 9597:OAT
uniprot id: A0A2R9B3M7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9597:FADS1
gene id: 9597:FADS1
uniprot id: A0A2R9CGV6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:MTMR2
gene id: 9597:MTMR2
uniprot id: A0A2R9CCM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9597:PLPPR4
gene id: 9597:PLPPR4
uniprot id: A0A2R8ZRA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9597:SEC23A
gene id: 9597:SEC23A
uniprot id: A0A2R8ZZK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9597:SPESP1
gene id: 9597:SPESP1
uniprot id: A0A2R9C237
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPESP1 family.
messages: Involved in fertilization ability of sperm.
messages: acrosome

9597:SCUBE3
gene id: 9597:SCUBE3
uniprot id: A0A2R9CN24
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:CAMK2N1
gene id: 9597:CAMK2N1
uniprot id: A0A2R9CHD7
names: Similarity
messages: Belongs to the CAMK2N family.

9597:MRPL22
gene id: 9597:MRPL22
uniprot id: A0A2R8ZV58
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9597:CRPPA
gene id: 9597:CRPPA
uniprot id: A0A2R9AYY5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Homodimer.
messages: cytosol

9597:FAXC
gene id: 9597:FAXC
uniprot id: A0A2R9C329
names: Similarity
messages: Belongs to the FAX family.

9597:MSL3
gene id: 9597:MSL3
uniprot id: A0A2R9BVN3
names: Subcellular Location Annotation
messages: Nucleus

9597:HDAC10
gene id: 9597:HDAC10
uniprot id: A0A2R9C5A7
uniprot id: A0A2R9C5B5
uniprot id: A0A2R9C5C1
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.

9597:ZNF879
gene id: 9597:ZNF879
uniprot id: A0A2R9ACJ3
names: Function
messages: May be involved in transcriptional regulation.

9597:TMEM176B
gene id: 9597:TMEM176B
uniprot id: A0A2R9B455
names: Similarity
messages: Belongs to the TMEM176 family.

9597:ITGAX
gene id: 9597:ITGAX
uniprot id: A0A2R9CEB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:LOC100989385
gene id: 9597:LOC100989385
uniprot id: A0A2R8ZBG5
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9597:CDK7
gene id: 9597:CDK7
uniprot id: A0A2R8ZZV4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9597:OVOL1
gene id: 9597:OVOL1
uniprot id: A0A2R8ZAZ8
names: Subcellular Location Annotation
messages: Nucleus

9597:KCNJ8
gene id: 9597:KCNJ8
uniprot id: A0A2R9BZP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9597:LOC100984974
gene id: 9597:LOC100984974
uniprot id: A0A2R9BHM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9597:BTBD10
gene id: 9597:BTBD10
uniprot id: A0A2R8ZGH8
uniprot id: A0A2R8ZMT5
names: Subcellular Location Annotation
messages: Cytoplasm

9597:CDH6
gene id: 9597:CDH6
uniprot id: A0A2R9AUM4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:LOC100976643
gene id: 9597:LOC100976643
uniprot id: A0A2R9AM62
names: Subcellular Location Annotation
messages: Nucleus

9597:SLU7
gene id: 9597:SLU7
uniprot id: A0A2R9ATP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9597:NDUFB9
gene id: 9597:NDUFB9
uniprot id: A0A2R9BV43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:RHBG
gene id: 9597:RHBG
uniprot id: A0A2R9AUJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9597:NAPB
gene id: 9597:NAPB
uniprot id: A0A2R9CL04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9597:FBLN2
gene id: 9597:FBLN2
uniprot id: A0A2R8ZIS8
uniprot id: A0A2R8ZLT8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:SLC13A4
gene id: 9597:SLC13A4
uniprot id: A0A2R9BPY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9597:PDCD5
gene id: 9597:PDCD5
uniprot id: A0A2R9CB80
uniprot id: A0A2R9CDY4
names: Similarity
messages: Belongs to the PDCD5 family.

9597:ATP10A
gene id: 9597:ATP10A
uniprot id: A0A2R8ZGK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9597:MAN2A1
gene id: 9597:MAN2A1
uniprot id: A0A2R9BN84
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9597:NKIRAS1
gene id: 9597:NKIRAS1
uniprot id: A0A2R9B1Q5
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9597:CDK10
gene id: 9597:CDK10
uniprot id: A0A2R9A3I8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:CD40
gene id: 9597:CD40
uniprot id: A0A2R9C4Y2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:KCNMB4
gene id: 9597:KCNMB4
uniprot id: A0A2R9BLF6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9597:EHHADH
gene id: 9597:EHHADH
uniprot id: A0A2R9C5M2
uniprot id: A0A2R9C5M5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9597:PTPN12
gene id: 9597:PTPN12
uniprot id: A0A2R9A8Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

9597:PLXNA3
gene id: 9597:PLXNA3
uniprot id: A0A2R9BG96
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:FMO3
gene id: 9597:FMO3
uniprot id: A0A2R9B212
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Membrane
messages: Microsome membrane

9597:GLMP
gene id: 9597:GLMP
uniprot id: A0A2R9A1F5
uniprot id: A0A2R9A6V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9597:SPACA4
gene id: 9597:SPACA4
uniprot id: A0A2R8ZJ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9597:SERPIND1
gene id: 9597:SERPIND1
uniprot id: A0A2R9C4A0
names: Similarity
messages: Belongs to the serpin family.

9597:ARL14
gene id: 9597:ARL14
uniprot id: A0A2R8ZGM7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9597:ALLC
gene id: 9597:ALLC
uniprot id: A0A2R9CJV7
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

9597:SFT2D1
gene id: 9597:SFT2D1
uniprot id: A0A2R8Z6F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9597:HNRNPC
gene id: 9597:HNRNPC
uniprot id: A0A2R9AWL7
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9597:VAMP2
gene id: 9597:VAMP2
uniprot id: A0A2R8ZRD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9597:KREMEN2
gene id: 9597:KREMEN2
uniprot id: A0A2R9CBG3
uniprot id: A0A2R9CJE4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

9597:STAG2
gene id: 9597:STAG2
uniprot id: A0A2R9BTK7
uniprot id: A0A2R9BU86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9597:RPS6KA4
gene id: 9597:RPS6KA4
uniprot id: A0A2R9A9L7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9597:PSMB9
gene id: 9597:PSMB9
uniprot id: A0A2R9BXY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9597:PTGER2
gene id: 9597:PTGER2
uniprot id: A0A2R9BKS0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:NOTCH4
gene id: 9597:NOTCH4
uniprot id: A0A2R9AC37
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9597:ATRX
gene id: 9597:ATRX
uniprot id: A0A2R9CKN0
uniprot id: A0A2R9CKP8
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9597:LOC100987488
gene id: 9597:LOC100987488
uniprot id: A0A2R9CHP6
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:GRPEL2
gene id: 9597:GRPEL2
uniprot id: A0A2R9AM09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9597:VPS37B
gene id: 9597:VPS37B
uniprot id: A0A2R9BHG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9597:SERPINA11
gene id: 9597:SERPINA11
uniprot id: A0A2R9BAT4
names: Similarity
messages: Belongs to the serpin family.

9597:EIF3G
gene id: 9597:EIF3G
uniprot id: A0A2R8ZXP0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9597:RAD52
gene id: 9597:RAD52
uniprot id: A0A2R8ZJX7
names: Similarity
messages: Belongs to the RAD52 family.

9597:LOC100990437
gene id: 9597:LOC100990437
uniprot id: A0A2R9BIH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

9597:YWHAE
gene id: 9597:YWHAE
uniprot id: A0A2R9AF76
names: Similarity
messages: Belongs to the 14-3-3 family.

9597:PPIH
gene id: 9597:PPIH
uniprot id: A0A2R9AZ52
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9597:CAMP
gene id: 9597:CAMP
uniprot id: A0A2R9CDL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro).
messages: Secreted
messages: Vesicle

9597:GORAB
gene id: 9597:GORAB
uniprot id: A0A2R8ZZP2
names: Similarity
messages: Belongs to the GORAB family.

9597:ASF1B
gene id: 9597:ASF1B
uniprot id: A0A2R8ZMD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9597:GLS2
gene id: 9597:GLS2
uniprot id: A0A2R8ZZ76
names: Similarity
messages: Belongs to the glutaminase family.

9597:GSDMD
gene id: 9597:GSDMD
uniprot id: A0A2R9BZY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9597:TCEA2
gene id: 9597:TCEA2
uniprot id: A0A2R9B8I3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9597:C19H19orf53
gene id: 9597:C19H19orf53
uniprot id: A0A2R9BTN2
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9597:LOC100984344
gene id: 9597:LOC100984344
uniprot id: A0A2R9AZ99
uniprot id: A0A2R9B0M1
uniprot id: A0A2R9B3A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9597:PDHX
gene id: 9597:PDHX
uniprot id: A0A2R9ACF8
uniprot id: A0A2R9AIF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9597:ALKBH7
gene id: 9597:ALKBH7
uniprot id: A0A2R9A4P4
names: Similarity
messages: Belongs to the alkB family.

9597:IFNGR1
gene id: 9597:IFNGR1
uniprot id: A0A2R9AUN0
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9597:MPDU1
gene id: 9597:MPDU1
uniprot id: A0A2R9C0V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

9597:SLC6A15
gene id: 9597:SLC6A15
uniprot id: A0A2R9CFW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Membrane

9597:ZEB2
gene id: 9597:ZEB2
uniprot id: A0A2R8ZPM1
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9597:ADAMTS3
gene id: 9597:ADAMTS3
uniprot id: A0A2R9CC15
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:GPR156
gene id: 9597:GPR156
uniprot id: A0A2R8ZUU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9597:NAPA
gene id: 9597:NAPA
uniprot id: A0A2R9AUR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9597:PLA2G2D
gene id: 9597:PLA2G2D
uniprot id: A0A2R9AN17
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9597:TMTC3
gene id: 9597:TMTC3
uniprot id: A0A2R9CCB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9597:SERPINB12
gene id: 9597:SERPINB12
uniprot id: A0A2R8ZU00
names: Similarity
messages: Belongs to the serpin family.

9597:TIMM50
gene id: 9597:TIMM50
uniprot id: A0A2R9CGD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

9597:GATM
gene id: 9597:GATM
uniprot id: A0A2R9CTN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain.

9597:RFTN2
gene id: 9597:RFTN2
uniprot id: A0A2R8ZX69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9597:SCPEP1
gene id: 9597:SCPEP1
uniprot id: A0A2R9CPC7
names: Similarity
messages: Belongs to the peptidase S10 family.

9597:ZNF615
gene id: 9597:ZNF615
uniprot id: A0A2R9BD23
names: Function
messages: May be involved in transcriptional regulation.

9597:XK
gene id: 9597:XK
uniprot id: A0A2R8ZJG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9597:BCOR
gene id: 9597:BCOR
uniprot id: A0A2R8ZUV0
names: Similarity
messages: Belongs to the BCOR family.

9597:VEGFC
gene id: 9597:VEGFC
uniprot id: A0A2R9CHL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9597:TINAG
gene id: 9597:TINAG
uniprot id: A0A2R9AH55
names: Similarity
messages: Belongs to the peptidase C1 family.

9597:RPS7
gene id: 9597:RPS7
uniprot id: A0A2R9BWL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: centrosome

9597:NAAA
gene id: 9597:NAAA
uniprot id: A0A2R9C7X5
uniprot id: A0A2R9CFJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9597:ALDH3B1
gene id: 9597:ALDH3B1
uniprot id: A0A2R9A9W4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9597:UCP3
gene id: 9597:UCP3
uniprot id: A0A2R9CJ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:MTMR7
gene id: 9597:MTMR7
uniprot id: A0A2R8ZAG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9597:LOC100974064
gene id: 9597:LOC100974064
uniprot id: A0A2R9C3U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9597:CMC4
gene id: 9597:CMC4
uniprot id: A0A2R9AEY1
names: Similarity
messages: Belongs to the CMC4 family.

9597:AMBN
gene id: 9597:AMBN
uniprot id: A0A2R9CKL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

9597:LOC100970460
gene id: 9597:LOC100970460
uniprot id: A0A2R8ZSC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9597:LAMTOR5
gene id: 9597:LAMTOR5
uniprot id: A0A2R9CGM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

9597:LOC100988476
gene id: 9597:LOC100988476
uniprot id: A0A2R8ZJC6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:RGR
gene id: 9597:RGR
uniprot id: A0A2R9C9Y3
names: Subcellular Location Annotation
messages: Membrane

9597:CASC3
gene id: 9597:CASC3
uniprot id: A0A2R9B9B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

9597:PRAF2
gene id: 9597:PRAF2
uniprot id: A0A2R9CC95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9597:SLC9A1
gene id: 9597:SLC9A1
uniprot id: A0A2R9CKJ5
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9597:LOC100992836
gene id: 9597:LOC100992836
uniprot id: A0A2R9AQ08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:GAREM1
gene id: 9597:GAREM1
uniprot id: A0A2R9AMT4
names: Similarity
messages: Belongs to the GAREM family.

9597:LOC100986591
gene id: 9597:LOC100986591
uniprot id: A0A2R9CMD5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:ST6GALNAC4
gene id: 9597:ST6GALNAC4
uniprot id: A0A2R9CDR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:LOC100992118
gene id: 9597:LOC100992118
uniprot id: A0A2R9AQM2
names: Similarity
messages: Belongs to the COX20 family.

9597:KIF5C
gene id: 9597:KIF5C
uniprot id: A0A2R9AM90
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:BCL2L10
gene id: 9597:BCL2L10
uniprot id: A0A2R9BCD9
names: Similarity
messages: Belongs to the Bcl-2 family.

9597:SLC39A10
gene id: 9597:SLC39A10
uniprot id: A0A2R9CCD6
names: Subcellular Location Annotation
messages: Membrane

9597:CCNG2
gene id: 9597:CCNG2
uniprot id: A0A2R9C0Z0
names: Similarity
messages: Belongs to the cyclin family.

9597:INIP
gene id: 9597:INIP
uniprot id: A0A2R9CLS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9597:AURKAIP1
gene id: 9597:AURKAIP1
uniprot id: A0A2R9B7S4
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mS38 family.

9597:IMP4
gene id: 9597:IMP4
uniprot id: A0A2R9A6L9
names: Subcellular Location Annotation
messages: nucleolus

9597:LOC100986707
gene id: 9597:LOC100986707
uniprot id: A0A2R9BUP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:EPCAM
gene id: 9597:EPCAM
uniprot id: A0A2R9A8B2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
messages: Membrane
messages: tight junction

9597:PDIA4
gene id: 9597:PDIA4
uniprot id: A0A2R9ALF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Part of a large chaperone multiprotein complex.

9597:PRKCE
gene id: 9597:PRKCE
uniprot id: A0A2R9AUU7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

9597:ADAM28
gene id: 9597:ADAM28
uniprot id: A0A2R9B5R7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:MRPL1
gene id: 9597:MRPL1
uniprot id: A0A2R9C628
names: Subcellular Location Annotation
messages: Mitochondrion

9597:HHATL
gene id: 9597:HHATL
uniprot id: A0A2R8ZYE8
names: Subcellular Location Annotation
messages: Membrane

9597:PRDX2
gene id: 9597:PRDX2
uniprot id: A0A2R9B3Q2
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9597:IL4R
gene id: 9597:IL4R
uniprot id: A0A2R9C7J4
names: Function
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

9597:NSUN7
gene id: 9597:NSUN7
uniprot id: A0A2R8ZLK5
uniprot id: A0A2R8ZMM2
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:DYNC1LI1
gene id: 9597:DYNC1LI1
uniprot id: A0A2R9BEJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9597:NUDT3
gene id: 9597:NUDT3
uniprot id: A0A2R9AF93
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9597:GALM
gene id: 9597:GALM
uniprot id: A0A2R9BWD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

9597:GSX2
gene id: 9597:GSX2
uniprot id: A0A2R9ACH4
names: Subcellular Location Annotation
messages: Nucleus

9597:CCT3
gene id: 9597:CCT3
uniprot id: A0A2R9CAM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9597:POGK
gene id: 9597:POGK
uniprot id: A0A2R9BIY7
names: Function
messages: May be involved in transcriptional regulation.

9597:DEFB119
gene id: 9597:DEFB119
uniprot id: A0A2R9A5R6
uniprot id: A0A2R9AAI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9597:CD34
gene id: 9597:CD34
uniprot id: A0A2R9BTK3
names: Subcellular Location Annotation
messages: Membrane

9597:ACAT1
gene id: 9597:ACAT1
uniprot id: A0A2R9B6L3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9597:MATK
gene id: 9597:MATK
uniprot id: A0A2R8ZAM3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9597:PANX1
gene id: 9597:PANX1
uniprot id: A0A2R9C7D5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9597:PRR15L
gene id: 9597:PRR15L
uniprot id: A0A2R8Z7H9
names: Similarity
messages: Belongs to the PRR15 family.

9597:ANXA11
gene id: 9597:ANXA11
uniprot id: A0A2R9B7V6
uniprot id: A0A2R9B9B5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9597:HDAC6
gene id: 9597:HDAC6
uniprot id: A0A2R9AX84
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.

9597:HSPA4L
gene id: 9597:HSPA4L
uniprot id: A0A2R9A3Z5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9597:FHIP1B
gene id: 9597:FHIP1B
uniprot id: A0A2R9AI96
names: Similarity
messages: Belongs to the FHIP family.

9597:PIK3C2B
gene id: 9597:PIK3C2B
uniprot id: A0A2R9AIX4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9597:SPO11
gene id: 9597:SPO11
uniprot id: A0A2R9B8U8
uniprot id: A0A2R9BGA0
names: Similarity
messages: Belongs to the TOP6A family.

9597:TSHZ2
gene id: 9597:TSHZ2
uniprot id: A0A2R9AIL8
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

9597:LVRN
gene id: 9597:LVRN
uniprot id: A0A2R9BDU8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9597:NAPG
gene id: 9597:NAPG
uniprot id: A0A2R9B7E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9597:GPRIN3
gene id: 9597:GPRIN3
uniprot id: A0A2R8ZIS6
names: Function
messages: May be involved in neurite outgrowth.

9597:KIF2C
gene id: 9597:KIF2C
uniprot id: A0A2R9CP97
uniprot id: A0A2R9CTM1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:TMEM91
gene id: 9597:TMEM91
uniprot id: A0A2R9BNY8
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9597:SLFN5
gene id: 9597:SLFN5
uniprot id: A0A2R9BJB5
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

9597:ZNF81
gene id: 9597:ZNF81
uniprot id: A0A2R8ZW46
names: Function
messages: May be involved in transcriptional regulation.

9597:SULT1E1
gene id: 9597:SULT1E1
uniprot id: A0A2R8ZSI9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:SLC31A1
gene id: 9597:SLC31A1
uniprot id: A0A2R9AXC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9597:RGS4
gene id: 9597:RGS4
uniprot id: A0A2R9ANC1
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9597:ZNF607
gene id: 9597:ZNF607
uniprot id: A0A2R8Z8N5
names: Function
messages: May be involved in transcriptional regulation.

9597:KCNS1
gene id: 9597:KCNS1
uniprot id: A0A2R9BES1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:CCL21
gene id: 9597:CCL21
uniprot id: A0A2R8ZHA3
names: Subcellular Location Annotation
messages: Secreted

9597:HYOU1
gene id: 9597:HYOU1
uniprot id: A0A2R8ZB00
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9597:SEPTIN3
gene id: 9597:SEPTIN3
uniprot id: A0A2R8ZHA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9597:ACP1
gene id: 9597:ACP1
uniprot id: A0A2R9AGN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9597:GJC1
gene id: 9597:GJC1
uniprot id: A0A2R8ZCV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:CRY1
gene id: 9597:CRY1
uniprot id: A0A2R8ZDU0
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

9597:CDC123
gene id: 9597:CDC123
uniprot id: A0A2R9BXU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9597:SELENOS
gene id: 9597:SELENOS
uniprot id: A0A2R9ADX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
messages: Membrane

9597:NIBAN2
gene id: 9597:NIBAN2
uniprot id: A0A2R9APM5
names: Similarity
messages: Belongs to the Niban family.

9597:LOC100981444
gene id: 9597:LOC100981444
uniprot id: Q646C7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:PPM1G
gene id: 9597:PPM1G
uniprot id: A0A2R9BH01
names: Similarity
messages: Belongs to the PP2C family.

9597:CRKL
gene id: 9597:CRKL
uniprot id: A0A2R8ZJE4
names: Similarity
messages: Belongs to the CRK family.

9597:GFRA1
gene id: 9597:GFRA1
uniprot id: A0A2R9AIA1
uniprot id: A0A2R9AQD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9597:PMPCA
gene id: 9597:PMPCA
uniprot id: A0A2R9BJK8
names: Similarity
messages: Belongs to the peptidase M16 family.

9597:SLC5A5
gene id: 9597:SLC5A5
uniprot id: A0A2R8ZYY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9597:DAZAP2
gene id: 9597:DAZAP2
uniprot id: A0A2R9C4E0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

9597:MEGF9
gene id: 9597:MEGF9
uniprot id: A0A2R8Z6A4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ST8SIA5
gene id: 9597:ST8SIA5
uniprot id: A0A2R9ANX6
uniprot id: A0A2R9APF8
uniprot id: A0A2R9ATE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:LOC100977675
gene id: 9597:LOC100977675
uniprot id: A0A2R8ZJR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CYP2A13
gene id: 9597:CYP2A13
uniprot id: A0A2R8ZAN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9597:MTFR1L
gene id: 9597:MTFR1L
uniprot id: A0A2R9AG98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9597:TIGD4
gene id: 9597:TIGD4
uniprot id: A0A2R8ZD26
names: Subcellular Location Annotation
messages: Nucleus

9597:MFSD8
gene id: 9597:MFSD8
uniprot id: A0A2R8ZFD7
uniprot id: A0A2R8ZFW1
uniprot id: A0A2R8ZLV6
names: Subcellular Location Annotation
messages: Membrane

9597:SEC61A1
gene id: 9597:SEC61A1
uniprot id: A0A2R8ZJ95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:ARMC1
gene id: 9597:ARMC1
uniprot id: A0A2R9C8U4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

9597:GABRR3
gene id: 9597:GABRR3
uniprot id: A0A2R9BJ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:SRPX
gene id: 9597:SRPX
uniprot id: A0A2R9BCH1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CAV1
gene id: 9597:CAV1
uniprot id: A0A2R9BGE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9597:CLDN1
gene id: 9597:CLDN1
uniprot id: A0A2R9B835
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:PLCD1
gene id: 9597:PLCD1
uniprot id: A0A2R8ZR69
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9597:GALE
gene id: 9597:GALE
uniprot id: A0A2R8ZDL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9597:C8B
gene id: 9597:C8B
uniprot id: A0A2R9C373
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:ANTXR2
gene id: 9597:ANTXR2
uniprot id: A0A2R9C7M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9597:CLIC1
gene id: 9597:CLIC1
uniprot id: A0A2R9APF0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

9597:SLC4A10
gene id: 9597:SLC4A10
uniprot id: A0A2R9BY66
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

9597:CCT6B
gene id: 9597:CCT6B
uniprot id: A0A2R9BEW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9597:LOC100994149
gene id: 9597:LOC100994149
uniprot id: A0A2R9B881
names: Similarity
messages: Belongs to the S-100 family.

9597:GBP2
gene id: 9597:GBP2
uniprot id: A0A2R9C4A8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9597:DEFB121
gene id: 9597:DEFB121
uniprot id: A0A2R9ABI8
uniprot id: A0A2R9AC16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9597:OAZ1
gene id: 9597:OAZ1
uniprot id: A0A2R9B0A3
names: Similarity
messages: Belongs to the ODC antizyme family.

9597:IFIH1
gene id: 9597:IFIH1
uniprot id: A0A2R9BSQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9597:GLYAT
gene id: 9597:GLYAT
uniprot id: A0A2R9BLT6
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9597:MID1
gene id: 9597:MID1
uniprot id: A0A2R9BLE9
names: Subcellular Location Annotation
messages: cytoskeleton

9597:TMEM11
gene id: 9597:TMEM11
uniprot id: A0A2R9CG01
uniprot id: A0A2R9CQB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Plays a role in mitochondrial morphogenesis.

9597:OLFM4
gene id: 9597:OLFM4
uniprot id: A0A2R9BC21
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ALPI
gene id: 9597:ALPI
uniprot id: A0A2R9AW48
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9597:COPS4
gene id: 9597:COPS4
uniprot id: A0A2R8ZN25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9597:AJUBA
gene id: 9597:AJUBA
uniprot id: A0A2R9AHL0
names: Similarity
messages: Belongs to the zyxin/ajuba family.

9597:LOC100976130
gene id: 9597:LOC100976130
uniprot id: A0A2R8ZAD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:FTMT
gene id: 9597:FTMT
uniprot id: A0A2R8ZN40
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9597:UNC5C
gene id: 9597:UNC5C
uniprot id: A0A2R9C6D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9597:TRDMT1
gene id: 9597:TRDMT1
uniprot id: A0A2R9ATZ5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9597:EPC1
gene id: 9597:EPC1
uniprot id: A0A2R9AP37
uniprot id: A0A2R9ASZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9597:SNW1
gene id: 9597:SNW1
uniprot id: A0A2R9C2Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9597:TMEM256
gene id: 9597:TMEM256
uniprot id: A0A2R9BY16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9597:TOR2A
gene id: 9597:TOR2A
uniprot id: A0A2R9C7V2
uniprot id: A0A2R9CIE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9597:POLR2K
gene id: 9597:POLR2K
uniprot id: A0A2R9C346
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9597:HOXC4
gene id: 9597:HOXC4
uniprot id: A0A2R9BS03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:PPP1CC
gene id: 9597:PPP1CC
uniprot id: A0A2R9AE39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9597:TPD52L1
gene id: 9597:TPD52L1
uniprot id: A0A2R8ZWU2
names: Similarity
messages: Belongs to the TPD52 family.

9597:LECT2
gene id: 9597:LECT2
uniprot id: A0A2R8Z767
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9597:SOX14
gene id: 9597:SOX14
uniprot id: A0A2R8ZCF2
names: Subcellular Location Annotation
messages: Nucleus

9597:SNX11
gene id: 9597:SNX11
uniprot id: A0A2R9ARH1
uniprot id: A0A2R9ARZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9597:CAMK2D
gene id: 9597:CAMK2D
uniprot id: A0A2R9AEX7
uniprot id: A0A2R9AEY3
uniprot id: A0A2R9AFW6
uniprot id: A0A2R9AJS9
uniprot id: A0A2R9AJT5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9597:SLC30A4
gene id: 9597:SLC30A4
uniprot id: A0A2R9CMM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9597:OSBPL3
gene id: 9597:OSBPL3
uniprot id: A0A2R9B046
uniprot id: A0A2R9B2X6
names: Similarity
messages: Belongs to the OSBP family.

9597:VSX1
gene id: 9597:VSX1
uniprot id: A0A2R9BYB3
uniprot id: A0A2R9BYB8
uniprot id: A0A2R9C1L9
names: Subcellular Location Annotation
messages: Nucleus

9597:PSMD4
gene id: 9597:PSMD4
uniprot id: A0A2R9AIV2
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9597:DBNDD1
gene id: 9597:DBNDD1
uniprot id: A0A2R9AE53
names: Similarity
messages: Belongs to the dysbindin family.

9597:SYNGR4
gene id: 9597:SYNGR4
uniprot id: A0A2R9CHQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9597:GIMAP8
gene id: 9597:GIMAP8
uniprot id: A0A2R9BXT4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9597:PPIL3
gene id: 9597:PPIL3
uniprot id: A0A2R9BSM7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9597:CYP11A1
gene id: 9597:CYP11A1
uniprot id: A0A2R9AUS6
uniprot id: A0A2R9AYY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion inner membrane

9597:PPA2
gene id: 9597:PPA2
uniprot id: A0A2R9CDE9
uniprot id: A0A2R9CNU0
names: Similarity
messages: Belongs to the PPase family.

9597:SRP14
gene id: 9597:SRP14
uniprot id: A0A2R9CPG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

9597:GNG3
gene id: 9597:GNG3
uniprot id: A0A2R9ASX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9597:IER3IP1
gene id: 9597:IER3IP1
uniprot id: A0A2R9A3N8
names: Similarity
messages: Belongs to the YOS1 family.

9597:TYRO3
gene id: 9597:TYRO3
uniprot id: A0A2R9BVM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

9597:INTS7
gene id: 9597:INTS7
uniprot id: A0A2R9CGY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9597:LOC103784643
gene id: 9597:LOC103784643
uniprot id: A0A2R9BRC2
names: Function
messages: May be involved in transcriptional regulation.

9597:LOC100988170
gene id: 9597:LOC100988170
uniprot id: A0A2R9APD1
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:SNX2
gene id: 9597:SNX2
uniprot id: A0A2R9AJ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9597:ATP6V1C1
gene id: 9597:ATP6V1C1
uniprot id: A0A2R9AF38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9597:CCL13
gene id: 9597:CCL13
uniprot id: A0A2R9C8T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:CNOT2
gene id: 9597:CNOT2
uniprot id: A0A2R9CD80
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9597:MARK2
gene id: 9597:MARK2
uniprot id: A0A2R9AQR7
uniprot id: A0A2R9AR61
uniprot id: A0A2R9AR77
uniprot id: A0A2R9AV64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9597:HHEX
gene id: 9597:HHEX
uniprot id: A0A2R9B8R3
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100973020
gene id: 9597:LOC100973020
uniprot id: A0A2R9A9A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9597:APC
gene id: 9597:APC
uniprot id: A0A2R9AUR0
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9597:DBNDD2
gene id: 9597:DBNDD2
uniprot id: A0A2R9BLB3
names: Similarity
messages: Belongs to the dysbindin family.

9597:MARK3
gene id: 9597:MARK3
uniprot id: A0A2R9AEA1
uniprot id: A0A2R9AJ56
uniprot id: A0A2R9AKV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9597:MFGE8
gene id: 9597:MFGE8
uniprot id: A0A2R8ZY45
uniprot id: A0A2R8ZY53
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CSNK2A1
gene id: 9597:CSNK2A1
uniprot id: A0A2R9AMW1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:NONO
gene id: 9597:NONO
uniprot id: A0A2R9ANT1
names: Subcellular Location Annotation
messages: Nucleus speckle

9597:AMER1
gene id: 9597:AMER1
uniprot id: A0A2R8ZC97
names: Similarity
messages: Belongs to the Amer family.

9597:LOC100974682
gene id: 9597:LOC100974682
uniprot id: A0A2R9BIW8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:DMPK
gene id: 9597:DMPK
uniprot id: A0A2R9CH60
uniprot id: A0A2R9CH69
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.

9597:CASR
gene id: 9597:CASR
uniprot id: A0A2R9BDK2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:ZNF230
gene id: 9597:ZNF230
uniprot id: A0A2R8ZK98
names: Function
messages: May be involved in transcriptional regulation.

9597:RHBDD3
gene id: 9597:RHBDD3
uniprot id: A0A2R9BIW6
names: Subcellular Location Annotation
messages: Membrane

9597:PFKFB4
gene id: 9597:PFKFB4
uniprot id: A0A2R9C0V9
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9597:GRM1
gene id: 9597:GRM1
uniprot id: A0A2R9CQ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9597:KIZ
gene id: 9597:KIZ
uniprot id: A0A2R9ALG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

9597:CDK1
gene id: 9597:CDK1
uniprot id: A0A2R9C1X9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:DMTF1
gene id: 9597:DMTF1
uniprot id: A0A2R9B7A4
names: Subcellular Location Annotation
messages: Nucleus

9597:TSPAN17
gene id: 9597:TSPAN17
uniprot id: A0A2R9BJR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:PAQR4
gene id: 9597:PAQR4
uniprot id: A0A2R9A4F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9597:PDE5A
gene id: 9597:PDE5A
uniprot id: A0A2R9CF87
uniprot id: A0A2R9CFA2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:CUTA
gene id: 9597:CUTA
uniprot id: A0A2R9BHL2
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9597:OGN
gene id: 9597:OGN
uniprot id: A0A2R9C3Y2
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9597:SRD5A1
gene id: 9597:SRD5A1
uniprot id: A0A2R9BNM1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

9597:MMP8
gene id: 9597:MMP8
uniprot id: A0A2R9A8Y9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9597:DNPEP
gene id: 9597:DNPEP
uniprot id: A0A2R9ARD6
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9597:NDUFB6
gene id: 9597:NDUFB6
uniprot id: A0A2R9BUN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:DLG1
gene id: 9597:DLG1
uniprot id: A0A2R9AUP6
uniprot id: A0A2R9AUP8
uniprot id: A0A2R9B0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9597:DCP1B
gene id: 9597:DCP1B
uniprot id: A0A2R9APP8
names: Similarity
messages: Belongs to the DCP1 family.

9597:ACTL7B
gene id: 9597:ACTL7B
uniprot id: A0A2R8ZJL1
names: Similarity
messages: Belongs to the actin family.

9597:THOC7
gene id: 9597:THOC7
uniprot id: A0A2R9CM75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

9597:IZUMO1
gene id: 9597:IZUMO1
uniprot id: A0A2R9A1Y2
names: Similarity
messages: Belongs to the Izumo family.

9597:DUOXA1
gene id: 9597:DUOXA1
uniprot id: A0A2R9AAZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9597:LDLRAD1
gene id: 9597:LDLRAD1
uniprot id: A0A2R9BH37
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:RANBP10
gene id: 9597:RANBP10
uniprot id: A0A2R9BMZ7
names: Similarity
messages: Belongs to the RANBP9/10 family.

9597:ADRM1
gene id: 9597:ADRM1
uniprot id: A0A2R8ZQA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADRM1 family.
messages: Cytoplasm
messages: Nucleus

9597:PTGS2
gene id: 9597:PTGS2
uniprot id: A0A2R9CG18
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TBC1D31
gene id: 9597:TBC1D31
uniprot id: A0A2R9A1C1
uniprot id: A0A2R9A5R0
names: Function
names: Subcellular Location Annotation
messages: Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
messages: centriolar satellite
messages: cilium basal body

9597:PRICKLE1
gene id: 9597:PRICKLE1
uniprot id: A0A2R9CEK7
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9597:BEND6
gene id: 9597:BEND6
uniprot id: A0A2R9BQJ0
names: Subcellular Location Annotation
messages: Nucleus

9597:TUBE1
gene id: 9597:TUBE1
uniprot id: A0A2R8ZTN8
names: Similarity
messages: Belongs to the tubulin family.

9597:RNASE6
gene id: 9597:RNASE6
uniprot id: A0A2R9ASD4
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9597:GRK7
gene id: 9597:GRK7
uniprot id: A0A2R9BHZ3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9597:NDRG4
gene id: 9597:NDRG4
uniprot id: A0A2R9BG45
uniprot id: A0A2R9BG55
uniprot id: A0A2R9BH21
names: Similarity
messages: Belongs to the NDRG family.

9597:DDI1
gene id: 9597:DDI1
uniprot id: A0A2R8ZIX9
names: Similarity
messages: Belongs to the DDI1 family.

9597:SLC25A1
gene id: 9597:SLC25A1
uniprot id: A0A2R8Z7R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:GMPPB
gene id: 9597:GMPPB
uniprot id: A0A2R9ANZ8
uniprot id: A0A2R9ATG2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9597:GOLT1B
gene id: 9597:GOLT1B
uniprot id: A0A2R9AI84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9597:MAST1
gene id: 9597:MAST1
uniprot id: A0A2R9B7I8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9597:TNPO1
gene id: 9597:TNPO1
uniprot id: A0A2R9CNL4
names: Subcellular Location Annotation
messages: Cytoplasm

9597:ALDH1B1
gene id: 9597:ALDH1B1
uniprot id: A0A2R8ZAD4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9597:TAF7L
gene id: 9597:TAF7L
uniprot id: A0A2R9ACS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9597:ATP10D
gene id: 9597:ATP10D
uniprot id: A0A2R8ZCR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9597:GATA2
gene id: 9597:GATA2
uniprot id: A0A2R8ZVR6
names: Subcellular Location Annotation
messages: Nucleus

9597:SLC2A8
gene id: 9597:SLC2A8
uniprot id: A0A2R9AB25
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9597:COQ8A
gene id: 9597:COQ8A
uniprot id: A0A2R9BPY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane

9597:MAPK10
gene id: 9597:MAPK10
uniprot id: A0A2R9CES1
uniprot id: A0A2R9CEV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9597:LOC100976603
gene id: 9597:LOC100976603
uniprot id: A0A2R8ZJR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:PAGE4
gene id: 9597:PAGE4
uniprot id: A0A2R9BI72
names: Similarity
messages: Belongs to the GAGE family.

9597:SNAP25
gene id: 9597:SNAP25
uniprot id: A0A2R9A2V1
uniprot id: A0A2R9A2V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9597:HTR3A
gene id: 9597:HTR3A
uniprot id: A0A2R8ZL47
uniprot id: A0A2R8ZM85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane

9597:NSUN6
gene id: 9597:NSUN6
uniprot id: A0A2R9CEG7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9597:TSC22D4
gene id: 9597:TSC22D4
uniprot id: A0A2R9CRS5
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9597:PTDSS2
gene id: 9597:PTDSS2
uniprot id: A0A2R8ZU87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:ETV5
gene id: 9597:ETV5
uniprot id: A0A2R9A101
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:RAD18
gene id: 9597:RAD18
uniprot id: A0A2R9BAL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9597:LAMC3
gene id: 9597:LAMC3
uniprot id: A0A2R9AYI2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9597:CSNK2B
gene id: 9597:CSNK2B
uniprot id: A0A2R8ZW67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

9597:SLC6A20
gene id: 9597:SLC6A20
uniprot id: A0A2R9AZP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9597:PLA2G2A
gene id: 9597:PLA2G2A
uniprot id: A0A2R8ZCM9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9597:TOP1MT
gene id: 9597:TOP1MT
uniprot id: A0A2R9AZF9
uniprot id: A0A2R9B3H0
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9597:SMIM19
gene id: 9597:SMIM19
uniprot id: A0A2R9B4S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9597:PFDN4
gene id: 9597:PFDN4
uniprot id: A0A2R9CGH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9597:GGT6
gene id: 9597:GGT6
uniprot id: A0A2R9BVE5
uniprot id: A0A2R9BY67
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

9597:RAMP1
gene id: 9597:RAMP1
uniprot id: A0A2R9B9U4
names: Similarity
messages: Belongs to the RAMP family.

9597:SDE2
gene id: 9597:SDE2
uniprot id: A0A2R9BHI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

9597:PIPOX
gene id: 9597:PIPOX
uniprot id: A0A2R9B5D3
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9597:MPPED2
gene id: 9597:MPPED2
uniprot id: A0A2R8ZLC2
names: Similarity
messages: Belongs to the UPF0046 family.

9597:TRAF3
gene id: 9597:TRAF3
uniprot id: A0A2R8ZXR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9597:TICAM1
gene id: 9597:TICAM1
uniprot id: B3Y693
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.
messages: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
messages: Mitochondrion
messages: The N-terminal region is essential for activation of the IFNB promoter activity.
messages: autophagosome
messages: cytosol

9597:PTGDS
gene id: 9597:PTGDS
uniprot id: A0A2R9C782
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9597:ENO2
gene id: 9597:ENO2
uniprot id: A0A2R9C6K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9597:SLC16A1
gene id: 9597:SLC16A1
uniprot id: A0A2R9AET5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9597:NR1D1
gene id: 9597:NR1D1
uniprot id: A0A2R9CEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9597:LOC100994951
gene id: 9597:LOC100994951
uniprot id: A0A2R9A2P3
names: Similarity
messages: Belongs to the ficolin lectin family.

9597:B4GALT4
gene id: 9597:B4GALT4
uniprot id: A0A2R9AXY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9597:SSBP1
gene id: 9597:SSBP1
uniprot id: A0A2R9B575
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9597:FAM167A
gene id: 9597:FAM167A
uniprot id: A0A2R8ZHJ9
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9597:GPBP1
gene id: 9597:GPBP1
uniprot id: A0A2R8ZVE5
uniprot id: A0A2R9A114
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9597:SYT17
gene id: 9597:SYT17
uniprot id: A0A2R8ZNJ8
uniprot id: A0A2R8ZT97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

9597:SERPINB8
gene id: 9597:SERPINB8
uniprot id: A0A2R9AD47
names: Similarity
messages: Belongs to the serpin family.

9597:GLCE
gene id: 9597:GLCE
uniprot id: A0A2R9AWN9
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9597:TMEM231
gene id: 9597:TMEM231
uniprot id: A0A2R9BYB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

9597:TUBD1
gene id: 9597:TUBD1
uniprot id: A0A2R9AIX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9597:COL4A1
gene id: 9597:COL4A1
uniprot id: A0A2R8ZQ62
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9597:CNN3
gene id: 9597:CNN3
uniprot id: A0A2R9A0L2
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9597:KCNJ6
gene id: 9597:KCNJ6
uniprot id: A0A2R9ASG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9597:POU3F4
gene id: 9597:POU3F4
uniprot id: A0A2R8ZGB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9597:LOC100992550
gene id: 9597:LOC100992550
uniprot id: A0A2R8ZJC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:ACKR4
gene id: 9597:ACKR4
uniprot id: A0A2R8ZFQ0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:KAT5
gene id: 9597:KAT5
uniprot id: A0A2R9C9W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9597:NAGK
gene id: 9597:NAGK
uniprot id: A0A2R9BU47
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9597:ADCY3
gene id: 9597:ADCY3
uniprot id: A0A2R9BLU9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9597:LOC100972036
gene id: 9597:LOC100972036
uniprot id: A0A2R8ZCU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ATP1B1
gene id: 9597:ATP1B1
uniprot id: A0A2R9BHW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9597:BLOC1S6
gene id: 9597:BLOC1S6
uniprot id: A0A2R8Z6N0
uniprot id: A0A2R8ZAC9
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9597:PACSIN2
gene id: 9597:PACSIN2
uniprot id: A0A2R9BEV2
uniprot id: A0A2R9BHF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

9597:ACADL
gene id: 9597:ACADL
uniprot id: A0A2R9B7K7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

9597:ARF6
gene id: 9597:ARF6
uniprot id: A0A2R9AS00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

9597:PTS
gene id: 9597:PTS
uniprot id: A0A2R9AR91
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9597:SPIN4
gene id: 9597:SPIN4
uniprot id: A0A2R8ZMM1
names: Similarity
messages: Belongs to the SPIN/STSY family.

9597:ALKBH2
gene id: 9597:ALKBH2
uniprot id: A0A2R9AWD5
names: Similarity
messages: Belongs to the alkB family.

9597:ASB9
gene id: 9597:ASB9
uniprot id: A0A2R9CJ65
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:SEC24C
gene id: 9597:SEC24C
uniprot id: A0A2R9C4I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9597:S1PR2
gene id: 9597:S1PR2
uniprot id: A0A2R8ZI74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:MTIF3
gene id: 9597:MTIF3
uniprot id: A0A2R8ZT32
names: Similarity
messages: Belongs to the IF-3 family.

9597:HOXD3
gene id: 9597:HOXD3
uniprot id: A0A2R9AIR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:PSMD3
gene id: 9597:PSMD3
uniprot id: A0A2R9A3G8
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9597:PLD1
gene id: 9597:PLD1
uniprot id: A0A2R9AP38
names: Similarity
messages: Belongs to the phospholipase D family.

9597:RNASEH2A
gene id: 9597:RNASEH2A
uniprot id: A0A2R9A386
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

9597:C1H1orf174
gene id: 9597:C1H1orf174
uniprot id: A0A2R9AGB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9597:ATG5
gene id: 9597:ATG5
uniprot id: A0A2R9C3I9
uniprot id: A0A2R9C3J6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9597:TMED5
gene id: 9597:TMED5
uniprot id: A0A2R8ZVQ1
uniprot id: A0A2R8ZXX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9597:TRUB1
gene id: 9597:TRUB1
uniprot id: A0A2R9CJH9
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9597:NAGA
gene id: 9597:NAGA
uniprot id: A0A2R9AYK2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9597:PPM1D
gene id: 9597:PPM1D
uniprot id: A0A2R8ZJH3
names: Similarity
messages: Belongs to the PP2C family.

9597:CUL4B
gene id: 9597:CUL4B
uniprot id: A0A2R9A0U8
names: Similarity
messages: Belongs to the cullin family.

9597:MRAP2
gene id: 9597:MRAP2
uniprot id: A0A2R9AGW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:STEAP4
gene id: 9597:STEAP4
uniprot id: A0A2R9ANB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9597:ACTG2
gene id: 9597:ACTG2
uniprot id: A0A2R9A4B9
uniprot id: A0A2R9A5I8
names: Similarity
messages: Belongs to the actin family.

9597:CDIP1
gene id: 9597:CDIP1
uniprot id: A0A2R9CDM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9597:UBA5
gene id: 9597:UBA5
uniprot id: A0A2R8ZX54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9597:DLX2
gene id: 9597:DLX2
uniprot id: A0A2R9BUW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9597:ASIC1
gene id: 9597:ASIC1
uniprot id: A0A2R9BGA3
names: Subcellular Location Annotation
messages: Membrane

9597:RECQL5
gene id: 9597:RECQL5
uniprot id: A0A2R9B0M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9597:LOC100991103
gene id: 9597:LOC100991103
uniprot id: A0A2R9CG76
uniprot id: A0A2R9CGD5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

9597:LOC100989330
gene id: 9597:LOC100989330
uniprot id: A0A2R9ANA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9597:KRT19
gene id: 9597:KRT19
uniprot id: A0A2R9ALU5
names: Similarity
messages: Belongs to the intermediate filament family.

9597:THTPA
gene id: 9597:THTPA
uniprot id: A0A2R8ZVM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9597:DZIP3
gene id: 9597:DZIP3
uniprot id: A0A2R9A1G2
names: Subcellular Location Annotation
messages: Cytoplasm

9597:CDH3
gene id: 9597:CDH3
uniprot id: A0A2R9BYH8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9597:L3MBTL3
gene id: 9597:L3MBTL3
uniprot id: A0A2R9C5Z8
uniprot id: A0A2R9C8T6
names: Subcellular Location Annotation
messages: Nucleus

9597:FOXI2
gene id: 9597:FOXI2
uniprot id: A0A2R9BTX1
names: Subcellular Location Annotation
messages: Nucleus

9597:RPP30
gene id: 9597:RPP30
uniprot id: A0A2R9CKB0
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

9597:MON1B
gene id: 9597:MON1B
uniprot id: A0A2R9A9T8
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9597:PIGC
gene id: 9597:PIGC
uniprot id: A0A2R8ZMT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9597:RBBP5
gene id: 9597:RBBP5
uniprot id: A0A2R8Z7Y3
uniprot id: A0A2R8ZEB6
names: Subcellular Location Annotation
messages: Nucleus

9597:LONP2
gene id: 9597:LONP2
uniprot id: A0A2R9AV09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
messages: Belongs to the peptidase S16 family.
messages: Interacts with PEX5. Interacts with TYSND1.
messages: Peroxisome matrix

9597:CCKAR
gene id: 9597:CCKAR
uniprot id: A0A2R8ZVR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9597:HYCC2
gene id: 9597:HYCC2
uniprot id: A0A2R9C234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9597:ADAM19
gene id: 9597:ADAM19
uniprot id: A0A2R9AQB2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TTC39C
gene id: 9597:TTC39C
uniprot id: A0A2R8ZMS9
names: Similarity
messages: Belongs to the TTC39 family.

9597:ATP5MC3
gene id: 9597:ATP5MC3
uniprot id: A0A2R9BB70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9597:CCNY
gene id: 9597:CCNY
uniprot id: A0A2R8ZQK7
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9597:NTS
gene id: 9597:NTS
uniprot id: A0A2R9ANN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9597:WAPL
gene id: 9597:WAPL
uniprot id: A0A2R9CBY1
names: Similarity
messages: Belongs to the WAPL family.

9597:TBC1D7
gene id: 9597:TBC1D7
uniprot id: A0A2R9CLM0
uniprot id: A0A2R9CS18
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9597:PLA2G15
gene id: 9597:PLA2G15
uniprot id: A0A2R9CBJ6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9597:ABCD4
gene id: 9597:ABCD4
uniprot id: A0A2R9C8E5
names: Subcellular Location Annotation
messages: Membrane

9597:ZDHHC20
gene id: 9597:ZDHHC20
uniprot id: A0A2R9ABG1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:LOC100992901
gene id: 9597:LOC100992901
uniprot id: A0A2R9ASN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:VWF
gene id: 9597:VWF
uniprot id: A0A2R8ZVE3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
messages: Multimeric. Interacts with F8.
messages: Secreted
messages: extracellular matrix

9597:SUGCT
gene id: 9597:SUGCT
uniprot id: A0A2R9CG36
names: Similarity
messages: Belongs to the CoA-transferase III family.

9597:TNFAIP6
gene id: 9597:TNFAIP6
uniprot id: A0A2R9ACW6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ZNF845
gene id: 9597:ZNF845
uniprot id: A0A2R9B965
names: Function
messages: May be involved in transcriptional regulation.

9597:BAX
gene id: 9597:BAX
uniprot id: A0A2R9BX16
names: Similarity
messages: Belongs to the Bcl-2 family.

9597:EIF3K
gene id: 9597:EIF3K
uniprot id: A0A2R8ZTV9
uniprot id: A0A2R8ZV29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9597:INSL6
gene id: 9597:INSL6
uniprot id: A0A2R8Z728
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: May have a role in sperm development and fertilization.
messages: Secreted

9597:ITGA3
gene id: 9597:ITGA3
uniprot id: A0A2R9AVE9
uniprot id: A0A2R9AZJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:SMG6
gene id: 9597:SMG6
uniprot id: A0A2R9CK46
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.
messages: Plays a role in nonsense-mediated mRNA decay.
messages: The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.
messages: cytosol
messages: nucleolus
messages: telomere

9597:LRWD1
gene id: 9597:LRWD1
uniprot id: A0A2R8ZZI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRWD1 family.
messages: centrosome
messages: kinetochore
messages: telomere

9597:HOATZ
gene id: 9597:HOATZ
uniprot id: A0A2R9A431
uniprot id: A0A2R9A436
names: Similarity
messages: Belongs to the HOATZ family.

9597:HOXC12
gene id: 9597:HOXC12
uniprot id: A0A2R9AD08
names: Subcellular Location Annotation
messages: Nucleus

9597:ZNF460
gene id: 9597:ZNF460
uniprot id: A0A2R9C8I3
names: Function
messages: May be involved in transcriptional regulation.

9597:NDUFB2
gene id: 9597:NDUFB2
uniprot id: A0A2R9BWD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:GOLM2
gene id: 9597:GOLM2
uniprot id: A0A2R8ZY29
uniprot id: A0A2R9A2I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9597:ANAPC15
gene id: 9597:ANAPC15
uniprot id: A0A2R8ZH31
names: Similarity
messages: Belongs to the APC15 family.

9597:USP37
gene id: 9597:USP37
uniprot id: A0A2R9A530
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9597:RPL15
gene id: 9597:RPL15
uniprot id: A0A2R9ARX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Cytoplasm

9597:MIEF2
gene id: 9597:MIEF2
uniprot id: A0A2R9CEC2
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9597:TMA16
gene id: 9597:TMA16
uniprot id: A0A2R8Z9K2
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9597:ALOX15
gene id: 9597:ALOX15
uniprot id: A0A2R9ABT1
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ELF4
gene id: 9597:ELF4
uniprot id: A0A2R9CJH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:MARVELD2
gene id: 9597:MARVELD2
uniprot id: A0A2R9APH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9597:SLC12A5
gene id: 9597:SLC12A5
uniprot id: A0A2R9CFZ8
uniprot id: A0A2R9CIQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9597:F10
gene id: 9597:F10
uniprot id: A0A2R9B696
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:TAFA3
gene id: 9597:TAFA3
uniprot id: A0A2R8ZUI9
names: Similarity
messages: Belongs to the TAFA family.

9597:MRPS18C
gene id: 9597:MRPS18C
uniprot id: A0A2R9BEQ3
uniprot id: A0A2R9BIL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9597:HOMEZ
gene id: 9597:HOMEZ
uniprot id: A0A2R9BK87
names: Subcellular Location Annotation
messages: Nucleus

9597:HTR2A
gene id: 9597:HTR2A
uniprot id: A0A2R8Z5S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

9597:C1H1orf74
gene id: 9597:C1H1orf74
uniprot id: A0A2R8ZKQ9
names: Similarity
messages: Belongs to the UPF0739 family.

9597:SARM1
gene id: 9597:SARM1
uniprot id: A0A2R9B3Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARM1 family.
messages: axon

9597:ZNF235
gene id: 9597:ZNF235
uniprot id: A0A2R9AI52
names: Function
messages: May be involved in transcriptional regulation.

9597:ZW10
gene id: 9597:ZW10
uniprot id: A0A2R9AI36
uniprot id: A0A2R9ALY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

9597:NECAP1
gene id: 9597:NECAP1
uniprot id: A0A2R9CG30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9597:POLL
gene id: 9597:POLL
uniprot id: A0A2R9BHW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9597:RIBC2
gene id: 9597:RIBC2
uniprot id: A0A2R9A302
names: Similarity
messages: Belongs to the RIB43A family.

9597:CCNI
gene id: 9597:CCNI
uniprot id: A0A2R9C8T1
names: Similarity
messages: Belongs to the cyclin family.

9597:SLC27A6
gene id: 9597:SLC27A6
uniprot id: A0A2R9CCJ0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:TFEC
gene id: 9597:TFEC
uniprot id: A0A2R8Z8K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9597:CHMP5
gene id: 9597:CHMP5
uniprot id: A0A2R9AXJ7
names: Similarity
messages: Belongs to the SNF7 family.

9597:DUSP26
gene id: 9597:DUSP26
uniprot id: A0A2R9BXG4
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9597:TSPAN6
gene id: 9597:TSPAN6
uniprot id: A0A2R9BMU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:EHD3
gene id: 9597:EHD3
uniprot id: A0A2R9B5I7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9597:REV1
gene id: 9597:REV1
uniprot id: A0A2R9ALL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

9597:SLC10A2
gene id: 9597:SLC10A2
uniprot id: A0A2R8ZLX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9597:AMHR2
gene id: 9597:AMHR2
uniprot id: A0A2R8ZS02
uniprot id: A0A2R8ZS13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

9597:NDUFA11
gene id: 9597:NDUFA11
uniprot id: A0A2R8ZMW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:TSR1
gene id: 9597:TSR1
uniprot id: A0A2R9BAB2
names: Subcellular Location Annotation
messages: nucleolus

9597:CERS2
gene id: 9597:CERS2
uniprot id: A0A2R9BW56
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9597:THUMPD3
gene id: 9597:THUMPD3
uniprot id: A0A2R8ZQS5
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9597:COG6
gene id: 9597:COG6
uniprot id: A0A2R9BPS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

9597:SNRPB
gene id: 9597:SNRPB
uniprot id: A0A2R9BA24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9597:EXO1
gene id: 9597:EXO1
uniprot id: A0A2R9BS47
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

9597:LOC100972973
gene id: 9597:LOC100972973
uniprot id: A0A2R8Z9P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ELOVL5
gene id: 9597:ELOVL5
uniprot id: A0A2R9B7U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: dendrite

9597:LIMK2
gene id: 9597:LIMK2
uniprot id: A0A2R9BXG1
uniprot id: A0A2R9BY65
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9597:IFI35
gene id: 9597:IFI35
uniprot id: A0A2R9A9X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9597:SGSM3
gene id: 9597:SGSM3
uniprot id: A0A2R9AIN2
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

9597:SLC20A1
gene id: 9597:SLC20A1
uniprot id: A0A2R9A132
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

9597:SP4
gene id: 9597:SP4
uniprot id: A0A2R9BDR5
names: Subcellular Location Annotation
messages: Nucleus

9597:NEK8
gene id: 9597:NEK8
uniprot id: A0A2R8ZBY5
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9597:CAPN7
gene id: 9597:CAPN7
uniprot id: A0A2R9AQ47
names: Similarity
messages: Belongs to the peptidase C2 family.

9597:TOMM20L
gene id: 9597:TOMM20L
uniprot id: A0A2R9CL66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:SLC35B1
gene id: 9597:SLC35B1
uniprot id: A0A2R9BLW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9597:TSEN15
gene id: 9597:TSEN15
uniprot id: A0A2R9AJ54
names: Similarity
messages: Belongs to the SEN15 family.

9597:DDX1
gene id: 9597:DDX1
uniprot id: A0A2R8ZXC2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule
messages: RNA helicase.
messages: The helicase domain is involved in the stimulation of RELA transcriptional activity.

9597:CDK2
gene id: 9597:CDK2
uniprot id: A0A2R9B4E4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:ORC5
gene id: 9597:ORC5
uniprot id: A0A2R9C1S3
names: Subcellular Location Annotation
messages: Nucleus

9597:TMEM208
gene id: 9597:TMEM208
uniprot id: A0A2R8ZZ40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9597:NIPBL
gene id: 9597:NIPBL
uniprot id: A0A2R9BVJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9597:SLC7A4
gene id: 9597:SLC7A4
uniprot id: A0A2R9A9F8
names: Subcellular Location Annotation
messages: Membrane

9597:GPR12
gene id: 9597:GPR12
uniprot id: A0A2R8ZDQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:ALDH1L1
gene id: 9597:ALDH1L1
uniprot id: A0A2R9AW45
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9597:TRAPPC1
gene id: 9597:TRAPPC1
uniprot id: A0A2R9A9B1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9597:NUP35
gene id: 9597:NUP35
uniprot id: A0A2R9BBH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9597:LOC103787041
gene id: 9597:LOC103787041
uniprot id: A0A2R9BL81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:GPR158
gene id: 9597:GPR158
uniprot id: A0A2R9AC25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:TIGD3
gene id: 9597:TIGD3
uniprot id: A0A2R8Z6K9
names: Subcellular Location Annotation
messages: Nucleus

9597:MRPL17
gene id: 9597:MRPL17
uniprot id: A0A2R9BT89
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9597:TINAGL1
gene id: 9597:TINAGL1
uniprot id: A0A2R9BGQ9
names: Similarity
messages: Belongs to the peptidase C1 family.

9597:ADAMTS14
gene id: 9597:ADAMTS14
uniprot id: A0A2R9A0L5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:EXOC8
gene id: 9597:EXOC8
uniprot id: A0A2R8Z9T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

9597:CLDN25
gene id: 9597:CLDN25
uniprot id: A0A2R8Z9P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9597:XPNPEP1
gene id: 9597:XPNPEP1
uniprot id: A0A2R8ZUH3
names: Similarity
messages: Belongs to the peptidase M24B family.

9597:PPP2R5B
gene id: 9597:PPP2R5B
uniprot id: A0A2R9AP80
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9597:LOC100986527
gene id: 9597:LOC100986527
uniprot id: A0A2R9BTR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9597:RPN2
gene id: 9597:RPN2
uniprot id: A0A2R9C2J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9597:PI4KB
gene id: 9597:PI4KB
uniprot id: A0A2R9BCM6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9597:FERMT1
gene id: 9597:FERMT1
uniprot id: A0A2R8ZHS3
names: Similarity
messages: Belongs to the kindlin family.

9597:RAMAC
gene id: 9597:RAMAC
uniprot id: A0A2R9CM02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAM family.
messages: Nucleus

9597:ZNF529
gene id: 9597:ZNF529
uniprot id: A0A2R9C1J6
names: Function
messages: May be involved in transcriptional regulation.

9597:CCNC
gene id: 9597:CCNC
uniprot id: A0A2R9A663
names: Similarity
messages: Belongs to the cyclin family.

9597:NDUFA7
gene id: 9597:NDUFA7
uniprot id: A0A2R9CL51
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

9597:AP5M1
gene id: 9597:AP5M1
uniprot id: A0A2R9CB95
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9597:SLC35E4
gene id: 9597:SLC35E4
uniprot id: A0A2R9ANN3
names: Subcellular Location Annotation
messages: Membrane

9597:RUNX1
gene id: 9597:RUNX1
uniprot id: A0A2R8Z7Z3
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9597:OASL
gene id: 9597:OASL
uniprot id: A0A2R9B9Z2
uniprot id: A0A2R9BFY8
names: Similarity
messages: Belongs to the 2-5A synthase family.

9597:OCA2
gene id: 9597:OCA2
uniprot id: A0A2R9BE00
names: Subcellular Location Annotation
messages: Membrane

9597:SESN3
gene id: 9597:SESN3
uniprot id: A0A2R8ZUF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9597:POLM
gene id: 9597:POLM
uniprot id: A0A2R9BRU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
messages: Nucleus

9597:LOC100980585
gene id: 9597:LOC100980585
uniprot id: A0A2R9BHL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:DRD1
gene id: 9597:DRD1
uniprot id: A0A2R8ZF27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
messages: Membrane
messages: dendritic spine

9597:ACTR8
gene id: 9597:ACTR8
uniprot id: A0A2R9ACB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9597:CDCA8
gene id: 9597:CDCA8
uniprot id: A0A2R9AEW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

9597:SHCBP1
gene id: 9597:SHCBP1
uniprot id: A0A2R9C6W8
names: Subcellular Location Annotation
messages: spindle

9597:OR7D4
gene id: 9597:OR7D4
uniprot id: D1MFA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ZNF793
gene id: 9597:ZNF793
uniprot id: A0A2R9BMP2
names: Function
messages: May be involved in transcriptional regulation.

9597:DENND6A
gene id: 9597:DENND6A
uniprot id: A0A2R9AW14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Recycling endosome

9597:GPR68
gene id: 9597:GPR68
uniprot id: A0A2R8Z941
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:ECSIT
gene id: 9597:ECSIT
uniprot id: A0A2R9BGV4
uniprot id: A0A2R9BHU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus

9597:GLIPR1L1
gene id: 9597:GLIPR1L1
uniprot id: A0A2R8ZWZ4
names: Similarity
messages: Belongs to the CRISP family.

9597:EFNA1
gene id: 9597:EFNA1
uniprot id: A0A2R8ZSH1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:FAM133B
gene id: 9597:FAM133B
uniprot id: A0A2R9BKK1
names: Similarity
messages: Belongs to the FAM133 family.

9597:SMARCAL1
gene id: 9597:SMARCAL1
uniprot id: A0A2R9CF28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

9597:MAPT
gene id: 9597:MAPT
uniprot id: A0A2R8Z985
uniprot id: A0A2R8Z9J4
uniprot id: A0A2R8ZFY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: axon
messages: cytoskeleton
messages: cytosol
messages: dendrite

9597:SLC25A19
gene id: 9597:SLC25A19
uniprot id: A0A2R9BB71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:MYLK2
gene id: 9597:MYLK2
uniprot id: A0A2R9C2Z8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May interact with centrin.

9597:PDE2A
gene id: 9597:PDE2A
uniprot id: A0A2R9BH84
uniprot id: A0A2R9BH94
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:LOC103785057
gene id: 9597:LOC103785057
uniprot id: A0A2R8ZM75
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9597:LIG4
gene id: 9597:LIG4
uniprot id: A0A2R9AQY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9597:COQ7
gene id: 9597:COQ7
uniprot id: A0A2R9BAP6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9597:VANGL2
gene id: 9597:VANGL2
uniprot id: A0A2R8ZHE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9597:DMRT1
gene id: 9597:DMRT1
uniprot id: A0A2R9BLJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9597:SIN3A
gene id: 9597:SIN3A
uniprot id: A0A2R9AMN1
names: Subcellular Location Annotation
messages: Nucleus

9597:PPP1R2
gene id: 9597:PPP1R2
uniprot id: A0A2R9CKM6
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9597:BMP2
gene id: 9597:BMP2
uniprot id: A0A2R9ABN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9597:TACC3
gene id: 9597:TACC3
uniprot id: A0A2R9C4N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

9597:MPV17
gene id: 9597:MPV17
uniprot id: A0A2R9AZ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9597:MIOS
gene id: 9597:MIOS
uniprot id: A0A2R8ZY77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane

9597:SETDB2
gene id: 9597:SETDB2
uniprot id: A0A2R9BX57
uniprot id: A0A2R9BZX0
names: Subcellular Location Annotation
messages: Chromosome

9597:TCIRG1
gene id: 9597:TCIRG1
uniprot id: A0A2R9A9H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9597:PPP6C
gene id: 9597:PPP6C
uniprot id: A0A2R8Z8V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9597:DDC
gene id: 9597:DDC
uniprot id: A0A2R9A9P2
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9597:CDC20
gene id: 9597:CDC20
uniprot id: A0A2R9AFL6
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9597:RPS16
gene id: 9597:RPS16
uniprot id: A0A2R8ZPD1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9597:LOC100968476
gene id: 9597:LOC100968476
uniprot id: A0A2R8Z8M8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:TESMIN
gene id: 9597:TESMIN
uniprot id: A0A2R9CCT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9597:NCL
gene id: 9597:NCL
uniprot id: A0A2R8ZC94
names: Function
names: Subcellular Location Annotation
messages: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
messages: nucleolus

9597:ERLIN2
gene id: 9597:ERLIN2
uniprot id: A0A2R9B717
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9597:UPP1
gene id: 9597:UPP1
uniprot id: A0A2R9AZ43
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9597:CFAP96
gene id: 9597:CFAP96
uniprot id: A0A2R8ZN92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP96 family.
messages: centrosome

9597:S100A2
gene id: 9597:S100A2
uniprot id: A0A2R9B689
names: Similarity
messages: Belongs to the S-100 family.

9597:YJU2
gene id: 9597:YJU2
uniprot id: A0A2R8ZE51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

9597:ZNF662
gene id: 9597:ZNF662
uniprot id: A0A2R9CB85
names: Function
messages: May be involved in transcriptional regulation.

9597:PLBD1
gene id: 9597:PLBD1
uniprot id: A0A2R9AF34
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9597:SART1
gene id: 9597:SART1
uniprot id: A0A2R9ABI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

9597:TTC27
gene id: 9597:TTC27
uniprot id: A0A2R9A5I4
names: Similarity
messages: Belongs to the TTC27 family.

9597:ITGA10
gene id: 9597:ITGA10
uniprot id: A0A2R9ACQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:ADPRM
gene id: 9597:ADPRM
uniprot id: A0A2R9CFU8
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

9597:RPS25
gene id: 9597:RPS25
uniprot id: A0A2R9A563
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the small ribosomal subunit.

9597:MRPL46
gene id: 9597:MRPL46
uniprot id: A0A2R9C178
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

9597:RPL26L1
gene id: 9597:RPL26L1
uniprot id: A0A2R9A6V7
uniprot id: A0A2R9A6W8
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9597:ZDHHC9
gene id: 9597:ZDHHC9
uniprot id: A0A2R9BRD8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:DPPA2
gene id: 9597:DPPA2
uniprot id: A0A2R8ZXS6
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100981207
gene id: 9597:LOC100981207
uniprot id: A0A2R8ZGN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TAGLN3
gene id: 9597:TAGLN3
uniprot id: A0A2R9BSF0
names: Similarity
messages: Belongs to the calponin family.

9597:CX3CL1
gene id: 9597:CX3CL1
uniprot id: A0A2R9BJ74
names: Subcellular Location Annotation
messages: Secreted

9597:PIGW
gene id: 9597:PIGW
uniprot id: A0A2R8ZPP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

9597:PLPP4
gene id: 9597:PLPP4
uniprot id: A0A2R9C2Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9597:ASB16
gene id: 9597:ASB16
uniprot id: A0A2R9ARQ9
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:ACTR6
gene id: 9597:ACTR6
uniprot id: A0A2R9B3B3
names: Similarity
messages: Belongs to the actin family.

9597:MOB1B
gene id: 9597:MOB1B
uniprot id: A0A2R9ARS9
uniprot id: A0A2R9AYC4
names: Similarity
messages: Belongs to the MOB1/phocein family.

9597:GUCY1B1
gene id: 9597:GUCY1B1
uniprot id: A0A2R8ZGT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9597:RAD23B
gene id: 9597:RAD23B
uniprot id: A0A2R9C4U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9597:AVPR1A
gene id: 9597:AVPR1A
uniprot id: A0A2R8ZWK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9597:N4BP3
gene id: 9597:N4BP3
uniprot id: A0A2R8ZSP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Vesicle
messages: dendrite

9597:LOC100982452
gene id: 9597:LOC100982452
uniprot id: A0A2R8ZVS6
names: Similarity
messages: Belongs to the apolipoprotein L family.

9597:B3GALNT2
gene id: 9597:B3GALNT2
uniprot id: A0A2R9B8J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:RNH1
gene id: 9597:RNH1
uniprot id: A0A2R9C9W9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

9597:TACC2
gene id: 9597:TACC2
uniprot id: A0A2R9BPI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

9597:HOXC13
gene id: 9597:HOXC13
uniprot id: A0A2R9B6H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9597:NDUFA5
gene id: 9597:NDUFA5
uniprot id: A0A2R9CJK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:CCL20
gene id: 9597:CCL20
uniprot id: A0A2R8ZHB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:RIF1
gene id: 9597:RIF1
uniprot id: A0A2R8ZPE7
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9597:MED21
gene id: 9597:MED21
uniprot id: A0A2R9AF15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9597:ZNF285
gene id: 9597:ZNF285
uniprot id: A0A2R9APL1
names: Function
messages: May be involved in transcriptional regulation.

9597:LOC100983382
gene id: 9597:LOC100983382
uniprot id: A0A2R9APA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ZNF785
gene id: 9597:ZNF785
uniprot id: A0A2R9CSC7
names: Function
messages: May be involved in transcriptional regulation.

9597:MRTO4
gene id: 9597:MRTO4
uniprot id: A0A2R9CMN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9597:NGDN
gene id: 9597:NGDN
uniprot id: A0A2R9BWW2
names: Subcellular Location Annotation
messages: nucleolus

9597:DKKL1
gene id: 9597:DKKL1
uniprot id: A0A2R8ZYM3
names: Subcellular Location Annotation
messages: Secreted

9597:PLA2G2F
gene id: 9597:PLA2G2F
uniprot id: A0A2R8ZZ19
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9597:SPOP
gene id: 9597:SPOP
uniprot id: A0A2R8ZSB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9597:RBP2
gene id: 9597:RBP2
uniprot id: A0A2R9APR6
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:DSC3
gene id: 9597:DSC3
uniprot id: A0A2R9C429
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9597:HK3
gene id: 9597:HK3
uniprot id: A0A2R9BGC9
names: Similarity
messages: Belongs to the hexokinase family.

9597:MAGT1
gene id: 9597:MAGT1
uniprot id: A0A2R9BIT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:LOC100992144
gene id: 9597:LOC100992144
uniprot id: A0A2R9B285
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:CLEC12B
gene id: 9597:CLEC12B
uniprot id: A0A2R9AB46
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:CTSS
gene id: 9597:CTSS
uniprot id: A0A2R9ABI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9597:FSHB
gene id: 9597:FSHB
uniprot id: A0A2R9BQ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9597:BUD23
gene id: 9597:BUD23
uniprot id: A0A2R9CE06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

9597:ACTMAP
gene id: 9597:ACTMAP
uniprot id: A0A2R9AIA6
names: Similarity
messages: Belongs to the ACTMAP family.

9597:TNFRSF1A
gene id: 9597:TNFRSF1A
uniprot id: A0A2R8ZK33
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:ST3GAL1
gene id: 9597:ST3GAL1
uniprot id: A0A2R9C5E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:CELF1
gene id: 9597:CELF1
uniprot id: A0A2R9AVQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9597:LOX
gene id: 9597:LOX
uniprot id: A0A2R9B5X9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9597:VPS35L
gene id: 9597:VPS35L
uniprot id: A0A2R9A304
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS35L family.
messages: Endosome

9597:SH3BGRL
gene id: 9597:SH3BGRL
uniprot id: A0A2R9B7T7
names: Similarity
messages: Belongs to the SH3BGR family.

9597:OTUB1
gene id: 9597:OTUB1
uniprot id: A0A2R8ZEY0
names: Similarity
messages: Belongs to the peptidase C65 family.

9597:DAPK3
gene id: 9597:DAPK3
uniprot id: A0A2R9A7I4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:MOSPD1
gene id: 9597:MOSPD1
uniprot id: A0A2R9AHI8
uniprot id: A0A2R9AM97
names: Subcellular Location Annotation
messages: Membrane

9597:HSD3B7
gene id: 9597:HSD3B7
uniprot id: A0A2R9A697
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9597:MDGA2
gene id: 9597:MDGA2
uniprot id: A0A2R9BP11
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:LOC100989257
gene id: 9597:LOC100989257
uniprot id: A0A2R9BK82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9597:UBA7
gene id: 9597:UBA7
uniprot id: A0A2R9A4T3
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9597:LOC100971944
gene id: 9597:LOC100971944
uniprot id: A0A2R9BQZ2
names: Similarity
messages: Belongs to the BCL7 family.

9597:RAG2
gene id: 9597:RAG2
uniprot id: A0A2R8ZER4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9597:AQP1
gene id: 9597:AQP1
uniprot id: A0A2R9B319
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9597:CD46
gene id: 9597:CD46
uniprot id: A0A2R8ZA38
uniprot id: A0A2R8ZGY4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: acrosome inner membrane

9597:TMEM86B
gene id: 9597:TMEM86B
uniprot id: A0A2R9A1I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9597:VAX2
gene id: 9597:VAX2
uniprot id: A0A2R8ZQQ8
names: Subcellular Location Annotation
messages: Nucleus

9597:IDH3G
gene id: 9597:IDH3G
uniprot id: A0A2R9C9Y4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9597:GNPDA2
gene id: 9597:GNPDA2
uniprot id: A0A2R9BM67
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9597:RPS6KA1
gene id: 9597:RPS6KA1
uniprot id: A0A2R9C519
uniprot id: A0A2R9C536
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9597:PIR
gene id: 9597:PIR
uniprot id: A0A2R9A827
names: Similarity
messages: Belongs to the pirin family.

9597:SOD2
gene id: 9597:SOD2
uniprot id: A0A2R9BMB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

9597:KDELR3
gene id: 9597:KDELR3
uniprot id: A0A2R9AB20
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:EIF5A2
gene id: 9597:EIF5A2
uniprot id: A0A2R9BAY0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

9597:DDOST
gene id: 9597:DDOST
uniprot id: A0A2R9BPC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

9597:LOC100979289
gene id: 9597:LOC100979289
uniprot id: A0A2R8ZGW2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:FTSJ1
gene id: 9597:FTSJ1
uniprot id: A0A2R9A0A8
uniprot id: A0A2R9A1G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

9597:USP26
gene id: 9597:USP26
uniprot id: A0A2R8ZF88
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9597:PCYOX1
gene id: 9597:PCYOX1
uniprot id: A0A2R9BF23
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9597:PITX2
gene id: 9597:PITX2
uniprot id: A0A2R9CCR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9597:PNPLA1
gene id: 9597:PNPLA1
uniprot id: A0A2R9A7L4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:VAC14
gene id: 9597:VAC14
uniprot id: A0A2R8ZXL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9597:LOC100979818
gene id: 9597:LOC100979818
uniprot id: A0A2R9CML0
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9597:PRPF38A
gene id: 9597:PRPF38A
uniprot id: A0A2R9AIU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9597:LOC100973935
gene id: 9597:LOC100973935
uniprot id: A0A2R8ZIK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SLCO5A1
gene id: 9597:SLCO5A1
uniprot id: A0A2R8ZIK4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TCTN2
gene id: 9597:TCTN2
uniprot id: A0A2R8ZT19
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9597:HTATSF1
gene id: 9597:HTATSF1
uniprot id: A0A2R8ZM86
names: Similarity
messages: Belongs to the HTATSF1 family.

9597:CCL18
gene id: 9597:CCL18
uniprot id: A0A2R9BML7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:PKLR
gene id: 9597:PKLR
uniprot id: A0A2R9C0K5
names: Similarity
messages: Belongs to the pyruvate kinase family.

9597:FLNC
gene id: 9597:FLNC
uniprot id: A0A2R9B668
uniprot id: A0A2R9BDB4
names: Similarity
messages: Belongs to the filamin family.

9597:ATP5MF
gene id: 9597:ATP5MF
uniprot id: A0A2R9BDW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9597:BOLA1
gene id: 9597:BOLA1
uniprot id: A0A2R8ZNI9
names: Similarity
messages: Belongs to the BolA/IbaG family.

9597:PIAS3
gene id: 9597:PIAS3
uniprot id: A0A2R9AN48
names: Similarity
messages: Belongs to the PIAS family.

9597:LEFTY2
gene id: 9597:LEFTY2
uniprot id: A0A2R9A9G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9597:CDK14
gene id: 9597:CDK14
uniprot id: A0A2R9CE45
uniprot id: A0A2R9CEA5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:TOM1
gene id: 9597:TOM1
uniprot id: A0A2R9BZ40
names: Similarity
messages: Belongs to the TOM1 family.

9597:STN1
gene id: 9597:STN1
uniprot id: A0A2R9AF72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9597:FAM229A
gene id: 9597:FAM229A
uniprot id: A0A2R9ARW7
names: Similarity
messages: Belongs to the FAM229 family.

9597:LOC100993591
gene id: 9597:LOC100993591
uniprot id: A0A2R9A341
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9597:FXYD2
gene id: 9597:FXYD2
uniprot id: A0A2R8ZPT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FXYD family.
messages: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
messages: Membrane
messages: Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

9597:IREB2
gene id: 9597:IREB2
uniprot id: A0A2R9BR28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Cytoplasm

9597:SLC16A7
gene id: 9597:SLC16A7
uniprot id: A0A2R9B438
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9597:CDSN
gene id: 9597:CDSN
uniprot id: A0A2R8ZXM2
names: Function
names: Subcellular Location Annotation
messages: Important for the epidermal barrier integrity.
messages: Secreted

9597:CALHM2
gene id: 9597:CALHM2
uniprot id: A0A2R9AEK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9597:RPL18A
gene id: 9597:RPL18A
uniprot id: A0A2R9BAC1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9597:MMP7
gene id: 9597:MMP7
uniprot id: A0A2R9AZJ1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9597:ZNF619
gene id: 9597:ZNF619
uniprot id: A0A2R9B7B8
names: Function
messages: May be involved in transcriptional regulation.

9597:DGKG
gene id: 9597:DGKG
uniprot id: A0A2R9AY61
uniprot id: A0A2R9B257
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9597:EIF3D
gene id: 9597:EIF3D
uniprot id: A0A2R9AH19
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9597:STX7
gene id: 9597:STX7
uniprot id: A0A2R8ZQ90
names: Similarity
messages: Belongs to the syntaxin family.

9597:CALHM4
gene id: 9597:CALHM4
uniprot id: A0A2R8ZL72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9597:NNMT
gene id: 9597:NNMT
uniprot id: A0A2R9A3D6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9597:AK8
gene id: 9597:AK8
uniprot id: A0A2R9B4R4
names: Similarity
messages: Belongs to the adenylate kinase family.

9597:LOC100989288
gene id: 9597:LOC100989288
uniprot id: A0A2R8ZIH0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TRAPPC3
gene id: 9597:TRAPPC3
uniprot id: A0A2R9CEI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9597:MYRF
gene id: 9597:MYRF
uniprot id: A0A2R9API6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

9597:DCTN5
gene id: 9597:DCTN5
uniprot id: A0A2R9AFU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

9597:EEF1G
gene id: 9597:EEF1G
uniprot id: A0A2R9CLP5
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9597:PEMT
gene id: 9597:PEMT
uniprot id: A0A2R8Z718
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9597:DOLPP1
gene id: 9597:DOLPP1
uniprot id: A0A2R9BRC9
uniprot id: A0A2R9BUU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9597:IQCG
gene id: 9597:IQCG
uniprot id: A0A2R9AK59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

9597:MOS
gene id: 9597:MOS
uniprot id: A0A2R8ZJ46
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:E2F6
gene id: 9597:E2F6
uniprot id: A0A2R9BBC3
uniprot id: A0A2R9BCQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9597:TNP1
gene id: 9597:TNP1
uniprot id: A0A2R8ZQC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Chromosome
messages: Nucleus

9597:GPM6B
gene id: 9597:GPM6B
uniprot id: A0A2R9BQI3
uniprot id: A0A2R9BQI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9597:LGMN
gene id: 9597:LGMN
uniprot id: A0A2R9BQF5
names: Similarity
messages: Belongs to the peptidase C13 family.

9597:TIPARP
gene id: 9597:TIPARP
uniprot id: A0A2R9A755
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:CLDN18
gene id: 9597:CLDN18
uniprot id: A0A2R8Z890
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9597:YIPF1
gene id: 9597:YIPF1
uniprot id: A0A2R9B953
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9597:ZNF891
gene id: 9597:ZNF891
uniprot id: A0A2R8Z7T5
names: Function
messages: May be involved in transcriptional regulation.

9597:TFCP2
gene id: 9597:TFCP2
uniprot id: A0A2R8ZHD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9597:TRIM46
gene id: 9597:TRIM46
uniprot id: A0A2R9A2Q7
uniprot id: A0A2R9A7C6
names: Subcellular Location Annotation
messages: cytoskeleton

9597:TRABD2A
gene id: 9597:TRABD2A
uniprot id: A0A2R9BW86
uniprot id: A0A2R9BW90
uniprot id: A0A2R9C5V8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9597:EXTL1
gene id: 9597:EXTL1
uniprot id: A0A2R8ZH50
uniprot id: A0A2R8ZH51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:DDX55
gene id: 9597:DDX55
uniprot id: A0A2R8Z8Y8
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9597:DLX5
gene id: 9597:DLX5
uniprot id: A0A2R9ALQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9597:RPS29
gene id: 9597:RPS29
uniprot id: A0A2R9AK38
uniprot id: A0A2R9AS94
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9597:BGLAP
gene id: 9597:BGLAP
uniprot id: A0A2R9CDC0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9597:LOC100986365
gene id: 9597:LOC100986365
uniprot id: A0A2R8ZIQ4
names: Similarity
messages: Belongs to the PRAME family.

9597:STX1B
gene id: 9597:STX1B
uniprot id: A0A2R9C7T7
names: Similarity
messages: Belongs to the syntaxin family.

9597:CCDC25
gene id: 9597:CCDC25
uniprot id: A0A2R9B6E7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9597:PNLDC1
gene id: 9597:PNLDC1
uniprot id: A0A2R8ZR07
names: Similarity
messages: Belongs to the CAF1 family.

9597:ARID5B
gene id: 9597:ARID5B
uniprot id: A0A2R9BMQ4
uniprot id: A0A2R9BWM5
names: Similarity
messages: Belongs to the ARID5B family.

9597:RDM1
gene id: 9597:RDM1
uniprot id: A0A2R9A9K3
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9597:RRM2
gene id: 9597:RRM2
uniprot id: A0A2R9C7C5
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9597:MT1X
gene id: 9597:MT1X
uniprot id: A0A2R9CCW2
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:RPS6KB2
gene id: 9597:RPS6KB2
uniprot id: A0A2R8ZFT7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9597:ASPH
gene id: 9597:ASPH
uniprot id: A0A2R9BAX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9597:CSF3R
gene id: 9597:CSF3R
uniprot id: A0A2R9BHK1
uniprot id: A0A2R9BQ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9597:FOLR3
gene id: 9597:FOLR3
uniprot id: A0A2R9CP43
names: Similarity
messages: Belongs to the folate receptor family.

9597:GRB2
gene id: 9597:GRB2
uniprot id: A0A2R9A3I9
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9597:TULP3
gene id: 9597:TULP3
uniprot id: A0A2R9A7A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9597:PSMD8
gene id: 9597:PSMD8
uniprot id: A0A2R9ATM2
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

9597:AGXT2
gene id: 9597:AGXT2
uniprot id: A0A2R9B5M5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9597:BTF3L4
gene id: 9597:BTF3L4
uniprot id: A0A2R8ZPI0
names: Similarity
messages: Belongs to the NAC-beta family.

9597:PMPCB
gene id: 9597:PMPCB
uniprot id: A0A2R9C334
names: Similarity
messages: Belongs to the peptidase M16 family.

9597:COMTD1
gene id: 9597:COMTD1
uniprot id: A0A2R9A5Z9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9597:CHMP3
gene id: 9597:CHMP3
uniprot id: A0A2R8ZUG4
names: Similarity
messages: Belongs to the SNF7 family.

9597:LOC100978953
gene id: 9597:LOC100978953
uniprot id: A0A2R8ZA96
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:FBXO34
gene id: 9597:FBXO34
uniprot id: A0A2R8ZNG7
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9597:TMEM170B
gene id: 9597:TMEM170B
uniprot id: A0A2R9AXE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9597:PRLHR
gene id: 9597:PRLHR
uniprot id: A0A2R8ZDB9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:LOC100995944
gene id: 9597:LOC100995944
uniprot id: A0A2R9B4Y5
names: Similarity
messages: Belongs to the TACO1 family.

9597:TMEM134
gene id: 9597:TMEM134
uniprot id: A0A2R9BPB8
uniprot id: A0A2R9BYC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

9597:TGM5
gene id: 9597:TGM5
uniprot id: A0A2R8Z5W5
uniprot id: A0A2R8Z9Q4
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9597:CYP4F8
gene id: 9597:CYP4F8
uniprot id: A0A2R8ZZP9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:TSHB
gene id: 9597:TSHB
uniprot id: A0A2R9AHW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9597:LOC100992178
gene id: 9597:LOC100992178
uniprot id: A0A2R8Z9M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:GPR179
gene id: 9597:GPR179
uniprot id: A0A2R9BUV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:EDEM3
gene id: 9597:EDEM3
uniprot id: A0A2R9BPZ4
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9597:UPF3B
gene id: 9597:UPF3B
uniprot id: A0A2R9BZN2
uniprot id: A0A2R9C080
names: Similarity
messages: Belongs to the RENT3 family.

9597:MASTL
gene id: 9597:MASTL
uniprot id: A0A2R9BTF3
uniprot id: A0A2R9BWV6
names: Subcellular Location Annotation
messages: Nucleus
messages: centrosome

9597:RPRD1A
gene id: 9597:RPRD1A
uniprot id: A0A2R8ZVE1
uniprot id: A0A2R8ZWL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

9597:PDCD4
gene id: 9597:PDCD4
uniprot id: A0A2R9C3Z6
names: Similarity
messages: Belongs to the PDCD4 family.

9597:DEUP1
gene id: 9597:DEUP1
uniprot id: A0A2R9A7E8
names: Similarity
messages: Belongs to the CEP63 family.

9597:CNTN2
gene id: 9597:CNTN2
uniprot id: A0A2R9A0W3
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9597:AURKA
gene id: 9597:AURKA
uniprot id: A0A2R9ANX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9597:SAMHD1
gene id: 9597:SAMHD1
uniprot id: H6WE98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

9597:BPNT1
gene id: 9597:BPNT1
uniprot id: A0A2R9AC40
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9597:SEMA4B
gene id: 9597:SEMA4B
uniprot id: A0A2R9BXZ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LCAT
gene id: 9597:LCAT
uniprot id: A0A2R9BD07
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9597:SLC9A8
gene id: 9597:SLC9A8
uniprot id: A0A2R9B3M6
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

9597:GMPR2
gene id: 9597:GMPR2
uniprot id: A0A2R9BZM2
uniprot id: A0A2R9C072
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:VXN
gene id: 9597:VXN
uniprot id: A0A2R9CDF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vexin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus

9597:LOC100995145
gene id: 9597:LOC100995145
uniprot id: A0A2R9B7Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9597:SLC15A2
gene id: 9597:SLC15A2
uniprot id: A0A2R9BFL3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9597:KIT
gene id: 9597:KIT
uniprot id: A0A2R9AUT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9597:SFR1
gene id: 9597:SFR1
uniprot id: A0A2R9BFZ8
uniprot id: A0A2R9BJQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

9597:HOXA6
gene id: 9597:HOXA6
uniprot id: A0A2R9BXR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9597:LAMTOR2
gene id: 9597:LAMTOR2
uniprot id: A0A2R9BH20
uniprot id: A0A2R9BQN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9597:PSMB7
gene id: 9597:PSMB7
uniprot id: A0A2R9CID4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9597:DRD3
gene id: 9597:DRD3
uniprot id: A0A2R9AV93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Membrane

9597:B3GAT1
gene id: 9597:B3GAT1
uniprot id: A0A2R9AKV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:FAM151B
gene id: 9597:FAM151B
uniprot id: A0A2R9BT92
names: Similarity
messages: Belongs to the FAM151 family.

9597:POFUT1
gene id: 9597:POFUT1
uniprot id: A0A2R9BCL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 65 family.
messages: Endoplasmic reticulum

9597:MEIS1
gene id: 9597:MEIS1
uniprot id: A0A2R9BFH6
uniprot id: A0A2R9BFJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9597:TRAPPC4
gene id: 9597:TRAPPC4
uniprot id: A0A2R9BV14
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9597:INPP4B
gene id: 9597:INPP4B
uniprot id: A0A2R9CP85
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9597:ZKSCAN1
gene id: 9597:ZKSCAN1
uniprot id: A0A2R9BHM6
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:CNIH1
gene id: 9597:CNIH1
uniprot id: A0A2R9AH71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9597:TNNI3
gene id: 9597:TNNI3
uniprot id: A0A2R9ATT7
names: Function
names: Similarity
messages: Belongs to the troponin I family.
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9597:TPM4
gene id: 9597:TPM4
uniprot id: A0A2R9BYH4
uniprot id: A0A2R9BZ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9597:DCK
gene id: 9597:DCK
uniprot id: A0A2R9BA40
names: Similarity
messages: Belongs to the DCK/DGK family.

9597:LOC100974743
gene id: 9597:LOC100974743
uniprot id: A0A2R9C869
names: Subcellular Location Annotation
messages: Membrane

9597:SEPTIN12
gene id: 9597:SEPTIN12
uniprot id: A0A2R9B1U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9597:CFC1B
gene id: 9597:CFC1B
uniprot id: A0A2R8ZTX6
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SDAD1
gene id: 9597:SDAD1
uniprot id: A0A2R9BSC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9597:EIF2B1
gene id: 9597:EIF2B1
uniprot id: A0A2R8ZMT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

9597:RAB3A
gene id: 9597:RAB3A
uniprot id: A0A2R9A383
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9597:MOSPD3
gene id: 9597:MOSPD3
uniprot id: A0A2R9CHN6
uniprot id: A0A2R9CHS7
names: Subcellular Location Annotation
messages: Membrane

9597:ATP6V1B2
gene id: 9597:ATP6V1B2
uniprot id: A0A2R9CR87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9597:P2RX1
gene id: 9597:P2RX1
uniprot id: A0A2R9AHU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9597:HBS1L
gene id: 9597:HBS1L
uniprot id: A0A2R9AE12
uniprot id: A0A2R9AE88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm

9597:WNT10B
gene id: 9597:WNT10B
uniprot id: A0A2R9B5H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:SYNGR3
gene id: 9597:SYNGR3
uniprot id: A0A2R9CD99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9597:MRGPRX2
gene id: 9597:MRGPRX2
uniprot id: A0A2R8ZJ26
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:MFSD9
gene id: 9597:MFSD9
uniprot id: A0A2R9BZN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9597:ACTN4
gene id: 9597:ACTN4
uniprot id: A0A2R9CB79
names: Similarity
messages: Belongs to the alpha-actinin family.

9597:TCAF1
gene id: 9597:TCAF1
uniprot id: A0A2R9CGI0
names: Similarity
messages: Belongs to the TCAF family.

9597:CYP1A2
gene id: 9597:CYP1A2
uniprot id: A0A2R8ZXU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9597:SMDT1
gene id: 9597:SMDT1
uniprot id: A0A2R9BBB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9597:ACTR3
gene id: 9597:ACTR3
uniprot id: A0A2R9C4Y1
names: Similarity
messages: Belongs to the actin family.

9597:MIX23
gene id: 9597:MIX23
uniprot id: A0A2R8ZZ87
names: Similarity
messages: Belongs to the MIX23 family.

9597:GTF2H4
gene id: 9597:GTF2H4
uniprot id: A0A2R9BWT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9597:YIPF6
gene id: 9597:YIPF6
uniprot id: A0A2R9CI42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:AHR
gene id: 9597:AHR
uniprot id: A0A2R9AFN6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:TTC4
gene id: 9597:TTC4
uniprot id: A0A2R9A9P0
names: Similarity
messages: Belongs to the TTC4 family.

9597:ZNF197
gene id: 9597:ZNF197
uniprot id: A0A2R8ZEJ1
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:ING3
gene id: 9597:ING3
uniprot id: A0A2R9A2Z0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9597:ST6GALNAC2
gene id: 9597:ST6GALNAC2
uniprot id: A0A2R9APX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:CGA
gene id: 9597:CGA
uniprot id: A0A2R9A0T2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted

9597:EHD1
gene id: 9597:EHD1
uniprot id: A0A2R9BNU0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9597:ZNF165
gene id: 9597:ZNF165
uniprot id: A0A2R9ASP6
names: Subcellular Location Annotation
messages: Nucleus

9597:DHRS11
gene id: 9597:DHRS11
uniprot id: A0A2R9AKF4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:ARR3
gene id: 9597:ARR3
uniprot id: A0A2R9A5X7
names: Similarity
messages: Belongs to the arrestin family.

9597:PRF1
gene id: 9597:PRF1
uniprot id: A0A2R9C5V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9597:SLC25A38
gene id: 9597:SLC25A38
uniprot id: A0A2R9AHF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9597:LOC100976806
gene id: 9597:LOC100976806
uniprot id: A0A2R8ZBD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LOC100987685
gene id: 9597:LOC100987685
uniprot id: A0A2R9B108
names: Subcellular Location Annotation
messages: Membrane

9597:STX17
gene id: 9597:STX17
uniprot id: A0A2R9BBS0
names: Similarity
messages: Belongs to the syntaxin family.

9597:MYOD1
gene id: 9597:MYOD1
uniprot id: A0A2R9BB02
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9597:TMEM63B
gene id: 9597:TMEM63B
uniprot id: A0A2R8ZS96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9597:SOSTDC1
gene id: 9597:SOSTDC1
uniprot id: A0A2R9B357
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SLC16A9
gene id: 9597:SLC16A9
uniprot id: A0A2R9ABF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane

9597:PER2
gene id: 9597:PER2
uniprot id: A0A2R9CHZ7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:DUSP1
gene id: 9597:DUSP1
uniprot id: A0A2R9A4E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9597:MRPL58
gene id: 9597:MRPL58
uniprot id: A0A2R9AR27
names: Subcellular Location Annotation
messages: Mitochondrion

9597:MYO9A
gene id: 9597:MYO9A
uniprot id: A0A2R9BBY5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:PDIK1L
gene id: 9597:PDIK1L
uniprot id: A0A2R8ZKW0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:ALG5
gene id: 9597:ALG5
uniprot id: A0A2R9BD74
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9597:KCNA6
gene id: 9597:KCNA6
uniprot id: A0A2R8ZAS1
names: Subcellular Location Annotation
messages: Membrane

9597:ST3GAL6
gene id: 9597:ST3GAL6
uniprot id: A0A2R8Z6P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9597:GPR33
gene id: 9597:GPR33
uniprot id: Q49SQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Orphan receptor; could be a chemoattractant receptor.

9597:NIPAL1
gene id: 9597:NIPAL1
uniprot id: A0A2R9AIH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9597:NR1H2
gene id: 9597:NR1H2
uniprot id: A0A2R8ZW74
uniprot id: A0A2R8ZW79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9597:PSENEN
gene id: 9597:PSENEN
uniprot id: A0A2R9APY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9597:CLCA4
gene id: 9597:CLCA4
uniprot id: A0A2R9AF53
names: Similarity
messages: Belongs to the CLCR family.

9597:LOC100986336
gene id: 9597:LOC100986336
uniprot id: A0A2R9AR52
uniprot id: B3Y663
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane
messages: cytoskeleton
messages: phagosome

9597:RPS28
gene id: 9597:RPS28
uniprot id: A0A2R9A306
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

9597:CCL2
gene id: 9597:CCL2
uniprot id: A0A2R9ARC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:TUBB4B
gene id: 9597:TUBB4B
uniprot id: A0A2R9AYQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9597:NXPH1
gene id: 9597:NXPH1
uniprot id: A0A2R9B5L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9597:SOD1
gene id: 9597:SOD1
uniprot id: A0A2R8ZYG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

9597:SSH2
gene id: 9597:SSH2
uniprot id: A0A2R9ATJ6
uniprot id: A0A2R9AXS9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9597:CYP4V2
gene id: 9597:CYP4V2
uniprot id: A0A2R8ZRT4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:OPTC
gene id: 9597:OPTC
uniprot id: A0A2R9CN77
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9597:ACTN1
gene id: 9597:ACTN1
uniprot id: A0A2R9BFF0
uniprot id: A0A2R9BFF6
uniprot id: A0A2R9BFG1
names: Similarity
messages: Belongs to the alpha-actinin family.

9597:SIRT5
gene id: 9597:SIRT5
uniprot id: A0A2R9AH39
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1.
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.
messages: Nucleus
messages: cytosol

9597:IL1R1
gene id: 9597:IL1R1
uniprot id: A0A2R9BU72
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9597:NCAPH
gene id: 9597:NCAPH
uniprot id: A0A2R9BZS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

9597:DDX31
gene id: 9597:DDX31
uniprot id: A0A2R8ZX27
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9597:NDNF
gene id: 9597:NDNF
uniprot id: A0A2R8ZI86
names: Subcellular Location Annotation
messages: Secreted

9597:MZF1
gene id: 9597:MZF1
uniprot id: A0A2R9ACI4
names: Subcellular Location Annotation
messages: Nucleus

9597:ARL4C
gene id: 9597:ARL4C
uniprot id: A0A2R8ZD81
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9597:CEP162
gene id: 9597:CEP162
uniprot id: A0A2R8ZUT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

9597:TMEM167B
gene id: 9597:TMEM167B
uniprot id: A0A2R9BKL3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:CCDC90B
gene id: 9597:CCDC90B
uniprot id: A0A2R9AN53
names: Similarity
messages: Belongs to the CCDC90 family.

9597:IL9
gene id: 9597:IL9
uniprot id: A0A2R9ANX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Secreted

9597:ALDH1A3
gene id: 9597:ALDH1A3
uniprot id: A0A2R9CDK5
uniprot id: A0A2R9CLP3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9597:SNRNP27
gene id: 9597:SNRNP27
uniprot id: A0A2R9BSD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9597:ITPA
gene id: 9597:ITPA
uniprot id: A0A2R9B6B8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9597:IFT20
gene id: 9597:IFT20
uniprot id: A0A2R8ZB42
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9597:LOC100986398
gene id: 9597:LOC100986398
uniprot id: A0A2R8ZLY5
uniprot id: A0A4Y1JWN7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:IRF5
gene id: 9597:IRF5
uniprot id: A0A2R9AHU1
names: Subcellular Location Annotation
messages: Nucleus

9597:SLC26A8
gene id: 9597:SLC26A8
uniprot id: A0A2R9BTP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9597:DYNLT2
gene id: 9597:DYNLT2
uniprot id: A0A2R9AIG3
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9597:OTC
gene id: 9597:OTC
uniprot id: A0A2R9AD21
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9597:HSD17B10
gene id: 9597:HSD17B10
uniprot id: A0A2R9ANQ0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:TES
gene id: 9597:TES
uniprot id: A0A2R9B209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: focal adhesion

9597:ZBTB8OS
gene id: 9597:ZBTB8OS
uniprot id: A0A2R9A793
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

9597:GET1
gene id: 9597:GET1
uniprot id: A0A2R9B4A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:UTP23
gene id: 9597:UTP23
uniprot id: A0A2R9A225
names: Subcellular Location Annotation
messages: nucleolus

9597:EMC4
gene id: 9597:EMC4
uniprot id: A0A2R9AL49
uniprot id: A0A2R9AL61
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:CLDN9
gene id: 9597:CLDN9
uniprot id: A0A2R8ZF85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:CHPF2
gene id: 9597:CHPF2
uniprot id: A0A2R8ZGX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9597:EFNB3
gene id: 9597:EFNB3
uniprot id: A0A2R8ZZZ1
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:AZIN1
gene id: 9597:AZIN1
uniprot id: A0A2R8ZXZ8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9597:LOC100984204
gene id: 9597:LOC100984204
uniprot id: A0A2R9B4W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:GABRA6
gene id: 9597:GABRA6
uniprot id: A0A2R8ZQ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:RNF146
gene id: 9597:RNF146
uniprot id: A0A2R8ZPI6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9597:DAP3
gene id: 9597:DAP3
uniprot id: A0A2R9AE81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

9597:FAM174B
gene id: 9597:FAM174B
uniprot id: A0A2R9B0I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9597:SLC26A7
gene id: 9597:SLC26A7
uniprot id: A0A2R8ZDU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9597:MRPS24
gene id: 9597:MRPS24
uniprot id: A0A2R8ZZ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

9597:LPCAT4
gene id: 9597:LPCAT4
uniprot id: A0A2R9B1Q1
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9597:HAPLN3
gene id: 9597:HAPLN3
uniprot id: A0A2R9B9J9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100986914
gene id: 9597:LOC100986914
uniprot id: A0A2R8ZJK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9597:ZSCAN9
gene id: 9597:ZSCAN9
uniprot id: A0A2R8ZM80
names: Subcellular Location Annotation
messages: Nucleus

9597:CYP51A1
gene id: 9597:CYP51A1
uniprot id: A0A2R9C313
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:RPS4X
gene id: 9597:RPS4X
uniprot id: A0A2R9C5L1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9597:DPH5
gene id: 9597:DPH5
uniprot id: A0A2R9AF90
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9597:TRRAP
gene id: 9597:TRRAP
uniprot id: A0A2R9BFY1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.

9597:TMEM254
gene id: 9597:TMEM254
uniprot id: A0A2R9BKD0
names: Subcellular Location Annotation
messages: Membrane

9597:LOC103785151
gene id: 9597:LOC103785151
uniprot id: A0A2R9AF17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9597:SHMT1
gene id: 9597:SHMT1
uniprot id: A0A2R9A9P3
uniprot id: A0A2R9ADM5
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9597:STEAP2
gene id: 9597:STEAP2
uniprot id: A0A2R8ZDU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9597:SCNN1B
gene id: 9597:SCNN1B
uniprot id: A0A2R9B176
names: Subcellular Location Annotation
messages: Membrane

9597:RBM10
gene id: 9597:RBM10
uniprot id: A0A2R9C265
names: Subcellular Location Annotation
messages: Nucleus

9597:FCER1G
gene id: 9597:FCER1G
uniprot id: A0A2R8ZQ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9597:SCTR
gene id: 9597:SCTR
uniprot id: A0A2R8ZBW6
names: Subcellular Location Annotation
messages: Membrane

9597:MCHR1
gene id: 9597:MCHR1
uniprot id: A0A2R9AFP0
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

9597:EVL
gene id: 9597:EVL
uniprot id: A0A2R9AR90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

9597:B3GNT3
gene id: 9597:B3GNT3
uniprot id: A0A2R9BUY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:SUSD3
gene id: 9597:SUSD3
uniprot id: A0A2R9BM86
uniprot id: A0A2R9BSF1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TMEM123
gene id: 9597:TMEM123
uniprot id: A0A2R9CBF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9597:RDH12
gene id: 9597:RDH12
uniprot id: A0A2R9C7Y4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:SLC16A5
gene id: 9597:SLC16A5
uniprot id: A0A2R9AGP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9597:OXCT1
gene id: 9597:OXCT1
uniprot id: A0A2R8ZA36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9597:PARP14
gene id: 9597:PARP14
uniprot id: A0A2R9BZN9
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:NOL12
gene id: 9597:NOL12
uniprot id: A0A2R9AMS3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP17 family.
messages: Interacts with KIAA1191.
messages: nucleolus

9597:TRUB2
gene id: 9597:TRUB2
uniprot id: A0A2R9CGK9
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9597:PTGDR
gene id: 9597:PTGDR
uniprot id: A0A2R9BPP7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:GAPDH
gene id: 9597:GAPDH
uniprot id: A0A2R9BWP9
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9597:MAMDC4
gene id: 9597:MAMDC4
uniprot id: A0A2R9BJX2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:EFEMP1
gene id: 9597:EFEMP1
uniprot id: A0A2R9AUY9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ATF7IP2
gene id: 9597:ATF7IP2
uniprot id: A0A2R9AQS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9597:LOC100985390
gene id: 9597:LOC100985390
uniprot id: A0A2R9AKG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:APOO
gene id: 9597:APOO
uniprot id: A0A2R9AXK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9597:TGIF2LX
gene id: 9597:TGIF2LX
uniprot id: A1YGI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/TGIF homeobox family.
messages: May have a transcription role in testis.
messages: Nucleus

9597:REEP2
gene id: 9597:REEP2
uniprot id: A0A2R9AKI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9597:FGF13
gene id: 9597:FGF13
uniprot id: A0A2R9BAH5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:DNAAF3
gene id: 9597:DNAAF3
uniprot id: A0A2R9AKX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF3 family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.

9597:PABPC4
gene id: 9597:PABPC4
uniprot id: A0A2R9CJF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9597:DNASE1L3
gene id: 9597:DNASE1L3
uniprot id: A0A2R9CDX2
names: Similarity
messages: Belongs to the DNase I family.

9597:SLC41A1
gene id: 9597:SLC41A1
uniprot id: A0A2R9AW46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9597:HHIP
gene id: 9597:HHIP
uniprot id: A0A2R9AW72
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SRMS
gene id: 9597:SRMS
uniprot id: A0A2R9ANH4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9597:LPCAT3
gene id: 9597:LPCAT3
uniprot id: A0A2R9BH33
names: Subcellular Location Annotation
messages: Membrane

9597:GORASP2
gene id: 9597:GORASP2
uniprot id: A0A2R9APA5
names: Similarity
messages: Belongs to the GORASP family.

9597:NEURL2
gene id: 9597:NEURL2
uniprot id: A0A2R9BZQ0
names: Subcellular Location Annotation
messages: Cytoplasm

9597:SLC2A4
gene id: 9597:SLC2A4
uniprot id: A0A2R8Z846
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9597:NMI
gene id: 9597:NMI
uniprot id: A0A2R9B1A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9597:LOC100979614
gene id: 9597:LOC100979614
uniprot id: A0A2R8ZNV6
names: Similarity
messages: Belongs to the pro/parathymosin family.

9597:MMGT1
gene id: 9597:MMGT1
uniprot id: A0A2R9AT41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

9597:KCNH5
gene id: 9597:KCNH5
uniprot id: A0A2R8ZTW0
names: Subcellular Location Annotation
messages: Membrane

9597:BEST3
gene id: 9597:BEST3
uniprot id: A0A2R9B2X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9597:LOC100988353
gene id: 9597:LOC100988353
uniprot id: A0A2R9A2N3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9597:MRPS16
gene id: 9597:MRPS16
uniprot id: A0A2R8ZAM2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9597:ZNF232
gene id: 9597:ZNF232
uniprot id: A0A2R9BW24
names: Subcellular Location Annotation
messages: Nucleus

9597:FLVCR1
gene id: 9597:FLVCR1
uniprot id: A0A2R9BHV5
names: Subcellular Location Annotation
messages: Membrane

9597:HSPA14
gene id: 9597:HSPA14
uniprot id: A0A2R8ZHF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9597:F8
gene id: 9597:F8
uniprot id: A0A2R9ATQ4
names: Similarity
messages: Belongs to the multicopper oxidase family.

9597:A4GNT
gene id: 9597:A4GNT
uniprot id: A0A2R9B7L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9597:FAM120B
gene id: 9597:FAM120B
uniprot id: A0A2R8ZIG7
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9597:PACSIN1
gene id: 9597:PACSIN1
uniprot id: A0A2R8ZCS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

9597:DCT
gene id: 9597:DCT
uniprot id: A0A2R8ZPM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9597:CEP43
gene id: 9597:CEP43
uniprot id: A0A2R9BS82
uniprot id: A0A2R9BVQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9597:NRM
gene id: 9597:NRM
uniprot id: A0A2R9C279
uniprot id: A0A2R9C2Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9597:RFLNA
gene id: 9597:RFLNA
uniprot id: A0A2R8ZKB5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9597:LOC106634652
gene id: 9597:LOC106634652
uniprot id: A0A2R8Z6E0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9597:DPYSL2
gene id: 9597:DPYSL2
uniprot id: A0A2R9B731
uniprot id: A0A2R9BAW2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9597:OCEL1
gene id: 9597:OCEL1
uniprot id: A0A2R9AKJ9
names: Similarity
messages: Belongs to the ELL/occludin family.

9597:AKR1C4
gene id: 9597:AKR1C4
uniprot id: A0A2R9AMJ4
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9597:CCNA2
gene id: 9597:CCNA2
uniprot id: A0A2R9BV77
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9597:RDH10
gene id: 9597:RDH10
uniprot id: A0A2R9C8G0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:MAN1B1
gene id: 9597:MAN1B1
uniprot id: A0A2R9BVG2
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9597:METTL6
gene id: 9597:METTL6
uniprot id: A0A2R9BTN7
uniprot id: A0A2R9BTP2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9597:RAB39A
gene id: 9597:RAB39A
uniprot id: A0A2R9CHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9597:LOC100989142
gene id: 9597:LOC100989142
uniprot id: A0A2R8ZJ97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:MSH2
gene id: 9597:MSH2
uniprot id: A0A2R9AXQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

9597:OSBPL9
gene id: 9597:OSBPL9
uniprot id: A0A2R8ZJS2
names: Similarity
messages: Belongs to the OSBP family.

9597:CHAC2
gene id: 9597:CHAC2
uniprot id: A0A2R9A270
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9597:ZNF510
gene id: 9597:ZNF510
uniprot id: A0A2R9BRL3
names: Function
messages: May be involved in transcriptional regulation.

9597:KCNS3
gene id: 9597:KCNS3
uniprot id: A0A2R8Z5X2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:DGAT1
gene id: 9597:DGAT1
uniprot id: A0A2R9B9G0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9597:DSC1
gene id: 9597:DSC1
uniprot id: A0A2R9BCF9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9597:HAPLN1
gene id: 9597:HAPLN1
uniprot id: A0A2R9BLD6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SMC4
gene id: 9597:SMC4
uniprot id: A0A2R9CEX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Chromosome
messages: Nucleus

9597:SV2C
gene id: 9597:SV2C
uniprot id: A0A2R9CB55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9597:ZAR1L
gene id: 9597:ZAR1L
uniprot id: A0A2R9BCX2
names: Similarity
names: Subunit
messages: Belongs to the ZAR1 family.
messages: Interacts with YBX2.

9597:GABRB1
gene id: 9597:GABRB1
uniprot id: A0A2R9C4H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:GABARAPL2
gene id: 9597:GABARAPL2
uniprot id: A0A2R9ASH1
names: Similarity
messages: Belongs to the ATG8 family.

9597:APMAP
gene id: 9597:APMAP
uniprot id: A0A2R9BGH7
names: Similarity
messages: Belongs to the strictosidine synthase family.

9597:GPHB5
gene id: 9597:GPHB5
uniprot id: A0A2R8Z911
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9597:LOC100976125
gene id: 9597:LOC100976125
uniprot id: A0A2R8ZCH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:AKAP8L
gene id: 9597:AKAP8L
uniprot id: A0A2R9A7D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AKAP95 family.
messages: Nucleus matrix

9597:WNT3
gene id: 9597:WNT3
uniprot id: A0A2R9BL18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:L3MBTL2
gene id: 9597:L3MBTL2
uniprot id: A0A2R9C1E1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

9597:EBF1
gene id: 9597:EBF1
uniprot id: A0A2R8ZFS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9597:AHSA1
gene id: 9597:AHSA1
uniprot id: A0A2R8ZMF0
names: Similarity
messages: Belongs to the AHA1 family.

9597:TNN
gene id: 9597:TNN
uniprot id: A0A2R9C535
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9597:TDP1
gene id: 9597:TDP1
uniprot id: A0A2R9A582
uniprot id: A0A2R9AAI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

9597:PRKAB1
gene id: 9597:PRKAB1
uniprot id: A0A2R9AUB1
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9597:MELK
gene id: 9597:MELK
uniprot id: A0A2R9CMJ7
uniprot id: A0A2R9CML8
uniprot id: A0A2R9CPC5
uniprot id: A0A2R9CTN6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9597:TDO2
gene id: 9597:TDO2
uniprot id: A0A2R8ZQE8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:KCNJ2
gene id: 9597:KCNJ2
uniprot id: A0A2R8ZA76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Membrane

9597:SEMA3B
gene id: 9597:SEMA3B
uniprot id: A0A2R9CEH4
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TMEM186
gene id: 9597:TMEM186
uniprot id: A0A2R9BFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9597:GSTO2
gene id: 9597:GSTO2
uniprot id: A0A2R9AHG4
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9597:LOC100983651
gene id: 9597:LOC100983651
uniprot id: A0A2R9B5J2
uniprot id: A0A2R9BCL5
names: Function
messages: May be involved in transcriptional regulation.

9597:CLRN1
gene id: 9597:CLRN1
uniprot id: A0A2R9CAI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9597:NDUFS3
gene id: 9597:NDUFS3
uniprot id: A0A2R9AFM3
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

9597:ACTL6B
gene id: 9597:ACTL6B
uniprot id: A0A2R9B2N6
names: Similarity
messages: Belongs to the actin family.

9597:ACSF2
gene id: 9597:ACSF2
uniprot id: A0A2R9CAF0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:ORMDL3
gene id: 9597:ORMDL3
uniprot id: A0A2R9BAU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9597:PPM1K
gene id: 9597:PPM1K
uniprot id: A0A2R9CCF4
names: Similarity
messages: Belongs to the PP2C family.

9597:MRPS11
gene id: 9597:MRPS11
uniprot id: A0A2R8ZYN8
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9597:LSM1
gene id: 9597:LSM1
uniprot id: A0A2R9ARA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9597:CLDN15
gene id: 9597:CLDN15
uniprot id: A0A2R9B8A6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:HOXC8
gene id: 9597:HOXC8
uniprot id: A0A2R9ASM5
names: Subcellular Location Annotation
messages: Nucleus

9597:NDUFA6
gene id: 9597:NDUFA6
uniprot id: A0A2R9BP15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:PEX5
gene id: 9597:PEX5
uniprot id: A0A2R9C1R3
uniprot id: A0A2R9C299
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9597:STX5
gene id: 9597:STX5
uniprot id: A0A2R9BX41
names: Similarity
messages: Belongs to the syntaxin family.

9597:ZNF768
gene id: 9597:ZNF768
uniprot id: A0A2R9BTQ1
names: Subcellular Location Annotation
messages: Nucleus

9597:SLC6A2
gene id: 9597:SLC6A2
uniprot id: A0A2R9AJ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9597:CAP1
gene id: 9597:CAP1
uniprot id: A0A2R9AZV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9597:ANKRD13C
gene id: 9597:ANKRD13C
uniprot id: A0A2R9B0Y8
names: Subcellular Location Annotation
messages: Membrane

9597:ABCD3
gene id: 9597:ABCD3
uniprot id: A0A2R9BW79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9597:NR5A2
gene id: 9597:NR5A2
uniprot id: A0A2R9BR60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9597:MARF1
gene id: 9597:MARF1
uniprot id: A0A2R9C740
names: Subcellular Location Annotation
messages: Peroxisome

9597:LYPD5
gene id: 9597:LYPD5
uniprot id: A0A2R9ABL4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:PPP1R12B
gene id: 9597:PPP1R12B
uniprot id: A0A2R8Z7L6
uniprot id: A0A2R8Z7M1
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9597:HEATR5B
gene id: 9597:HEATR5B
uniprot id: A0A2R9C824
names: Similarity
messages: Belongs to the HEATR5 family.

9597:LOC100977135
gene id: 9597:LOC100977135
uniprot id: A0A2R9AC19
names: Similarity
messages: Belongs to the globin family.

9597:GDF10
gene id: 9597:GDF10
uniprot id: A0A2R9C5P7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9597:KIF24
gene id: 9597:KIF24
uniprot id: A0A2R9A000
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:NCDN
gene id: 9597:NCDN
uniprot id: A0A2R9BZC2
uniprot id: A0A2R9C2I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

9597:ERN1
gene id: 9597:ERN1
uniprot id: A0A2R9AFY5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:FOXI1
gene id: 9597:FOXI1
uniprot id: A0A2R8ZMY1
names: Subcellular Location Annotation
messages: Nucleus

9597:ACADM
gene id: 9597:ACADM
uniprot id: A0A2R9BBV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Mitochondrion matrix

9597:RMND1
gene id: 9597:RMND1
uniprot id: A0A2R9B6V6
names: Similarity
messages: Belongs to the RMD1/sif2 family.

9597:CD14
gene id: 9597:CD14
uniprot id: B3Y6B4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane raft
messages: Secreted

9597:LOC100987427
gene id: 9597:LOC100987427
uniprot id: A0A2R9A2Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9597:LOC103785895
gene id: 9597:LOC103785895
uniprot id: A0A2R8ZQQ2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9597:ZNF548
gene id: 9597:ZNF548
uniprot id: A0A2R9BTA0
names: Function
messages: May be involved in transcriptional regulation.

9597:TYR
gene id: 9597:TYR
uniprot id: A0A2R9A709
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9597:PAM
gene id: 9597:PAM
uniprot id: A0A2R9A3K2
uniprot id: A0A2R9A917
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 2 Cu(2+) ions per subunit.
messages: Binds one Zn(2+) ion per subunit.
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

9597:LOC100970874
gene id: 9597:LOC100970874
uniprot id: A0A2R9C5I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9597:NETO1
gene id: 9597:NETO1
uniprot id: A0A2R8ZPB0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ACYP1
gene id: 9597:ACYP1
uniprot id: A0A2R8ZV40
uniprot id: A0A2R8ZX98
names: Similarity
messages: Belongs to the acylphosphatase family.

9597:BABAM2
gene id: 9597:BABAM2
uniprot id: A0A2R9BRV7
uniprot id: A0A2R9C0X7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

9597:SGTB
gene id: 9597:SGTB
uniprot id: A0A2R9BWR2
names: Similarity
messages: Belongs to the SGT family.

9597:SNRPD2
gene id: 9597:SNRPD2
uniprot id: A0A2R9BU17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: cytosol

9597:EGFL6
gene id: 9597:EGFL6
uniprot id: A0A2R9A753
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:SHKBP1
gene id: 9597:SHKBP1
uniprot id: A0A2R9CLG4
names: Similarity
messages: Belongs to the KCTD3 family.

9597:TIPIN
gene id: 9597:TIPIN
uniprot id: A0A2R9AZ91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

9597:CASP1
gene id: 9597:CASP1
uniprot id: A0A2R9AB18
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:SH3RF2
gene id: 9597:SH3RF2
uniprot id: A0A2R9CMR3
names: Similarity
messages: Belongs to the SH3RF family.

9597:TMEM184C
gene id: 9597:TMEM184C
uniprot id: A0A2R9AN83
names: Subcellular Location Annotation
messages: Membrane

9597:SEMA4D
gene id: 9597:SEMA4D
uniprot id: A0A2R8Z765
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:ABLIM2
gene id: 9597:ABLIM2
uniprot id: A0A2R9B270
names: Subcellular Location Annotation
messages: Cytoplasm

9597:MSN
gene id: 9597:MSN
uniprot id: A0A2R9AZU4
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9597:PAF1
gene id: 9597:PAF1
uniprot id: A0A2R8ZXI6
names: Similarity
messages: Belongs to the PAF1 family.

9597:MMP3
gene id: 9597:MMP3
uniprot id: A0A2R9BCT7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9597:AGT
gene id: 9597:AGT
uniprot id: A0A2R8ZSQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

9597:ZFPL1
gene id: 9597:ZFPL1
uniprot id: A0A2R8ZI90
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

9597:FAT4
gene id: 9597:FAT4
uniprot id: A0A2R9AP84
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100969885
gene id: 9597:LOC100969885
uniprot id: A0A2R9CFS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9597:LOC100980944
gene id: 9597:LOC100980944
uniprot id: A0A2R8ZUW8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9597:LOC103786029
gene id: 9597:LOC103786029
uniprot id: A0A2R8ZUE3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:KCNJ15
gene id: 9597:KCNJ15
uniprot id: A0A2R9AKM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9597:EIF4A2
gene id: 9597:EIF4A2
uniprot id: A0A2R8ZFC3
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9597:GPBP1L1
gene id: 9597:GPBP1L1
uniprot id: A0A2R9BWN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9597:TMEM14C
gene id: 9597:TMEM14C
uniprot id: A0A2R9BX17
names: Similarity
messages: Belongs to the TMEM14 family.

9597:EFNB1
gene id: 9597:EFNB1
uniprot id: A0A2R9C3A4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TRAK1
gene id: 9597:TRAK1
uniprot id: A0A2R9A2T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9597:CHGB
gene id: 9597:CHGB
uniprot id: A0A2R9AN01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9597:MOCOS
gene id: 9597:MOCOS
uniprot id: A0A2R9AB12
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

9597:CHMP4C
gene id: 9597:CHMP4C
uniprot id: A0A2R9C9K3
names: Similarity
messages: Belongs to the SNF7 family.

9597:KCNK13
gene id: 9597:KCNK13
uniprot id: A0A2R9C9D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9597:GUCA2B
gene id: 9597:GUCA2B
uniprot id: A0A2R9BDN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9597:SLC18A3
gene id: 9597:SLC18A3
uniprot id: A0A2R9AKG9
names: Subcellular Location Annotation
messages: Membrane

9597:TYW3
gene id: 9597:TYW3
uniprot id: A0A2R9CIA4
uniprot id: A0A2R9CKX5
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9597:ACY3
gene id: 9597:ACY3
uniprot id: A0A2R9AI91
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9597:TMEM126A
gene id: 9597:TMEM126A
uniprot id: A0A2R9AB75
names: Subcellular Location Annotation
messages: Membrane

9597:ADAMTS9
gene id: 9597:ADAMTS9
uniprot id: A0A2R8ZXK3
uniprot id: A0A2R8ZXK9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:MRPL37
gene id: 9597:MRPL37
uniprot id: A0A2R9C6B6
names: Subcellular Location Annotation
messages: Mitochondrion

9597:EP300
gene id: 9597:EP300
uniprot id: A0A2R9ATU0
names: Subcellular Location Annotation
messages: Cytoplasm

9597:PFDN5
gene id: 9597:PFDN5
uniprot id: A0A2R9BEU9
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9597:TAS2R39
gene id: 9597:TAS2R39
uniprot id: Q646C8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:CARNMT1
gene id: 9597:CARNMT1
uniprot id: A0A2R9BQL8
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

9597:SMPDL3B
gene id: 9597:SMPDL3B
uniprot id: A0A2R9ASF8
uniprot id: A0A2R9AWT9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9597:NDE1
gene id: 9597:NDE1
uniprot id: A0A2R9B0A7
uniprot id: A0A2R9B300
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9597:ATP6V0C
gene id: 9597:ATP6V0C
uniprot id: A0A2R9C662
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9597:ATP2B2
gene id: 9597:ATP2B2
uniprot id: A0A2R9CH85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:PERP
gene id: 9597:PERP
uniprot id: A0A2R9BV32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9597:SCGB1D1
gene id: 9597:SCGB1D1
uniprot id: A0A2R9BL12
names: Subcellular Location Annotation
messages: Secreted

9597:LOC103785741
gene id: 9597:LOC103785741
uniprot id: A0A2R9CHC6
names: Function
messages: May be involved in transcriptional regulation.

9597:CPEB4
gene id: 9597:CPEB4
uniprot id: A0A2R9ACA4
uniprot id: A0A2R9ACB4
uniprot id: A0A2R9AH90
uniprot id: A0A2R9AH93
names: Similarity
messages: Belongs to the RRM CPEB family.

9597:CS
gene id: 9597:CS
uniprot id: A0A2R9BCW0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Homodimer.
messages: Mitochondrion matrix

9597:SMARCAD1
gene id: 9597:SMARCAD1
uniprot id: A0A2R9B6H0
names: Subcellular Location Annotation
messages: Chromosome

9597:LOC103782649
gene id: 9597:LOC103782649
uniprot id: A0A2R9C949
names: Function
messages: May be involved in transcriptional regulation.

9597:CCT2
gene id: 9597:CCT2
uniprot id: A0A2R8ZJW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9597:IZUMO2
gene id: 9597:IZUMO2
uniprot id: A0A2R9BH87
names: Similarity
messages: Belongs to the Izumo family.

9597:GINS4
gene id: 9597:GINS4
uniprot id: A0A2R8ZEX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9597:CHRM4
gene id: 9597:CHRM4
uniprot id: A0A2R8ZNY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9597:AMZ2
gene id: 9597:AMZ2
uniprot id: A0A2R9AVH1
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9597:SSR2
gene id: 9597:SSR2
uniprot id: A0A2R9BCX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9597:APH1B
gene id: 9597:APH1B
uniprot id: A0A2R8ZDL1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9597:GINS3
gene id: 9597:GINS3
uniprot id: A0A2R9B3X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9597:ZNF875
gene id: 9597:ZNF875
uniprot id: A0A2R9A6J8
names: Function
messages: May be involved in transcriptional regulation.

9597:F2RL3
gene id: 9597:F2RL3
uniprot id: A0A2R9ADF6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:LOC100991027
gene id: 9597:LOC100991027
uniprot id: A0A2R9APU6
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9597:CERS5
gene id: 9597:CERS5
uniprot id: A0A2R9B4F4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9597:ARL11
gene id: 9597:ARL11
uniprot id: A0A2R9ART4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9597:LUC7L
gene id: 9597:LUC7L
uniprot id: A0A2R9C853
uniprot id: A0A2R9C854
names: Similarity
messages: Belongs to the Luc7 family.

9597:CCN3
gene id: 9597:CCN3
uniprot id: A0A2R9ABL5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:SSX2IP
gene id: 9597:SSX2IP
uniprot id: A0A2R9AFH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

9597:KRT77
gene id: 9597:KRT77
uniprot id: A0A2R9ANL2
names: Similarity
messages: Belongs to the intermediate filament family.

9597:NDUFB4
gene id: 9597:NDUFB4
uniprot id: A0A2R8ZZB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:CNDP1
gene id: 9597:CNDP1
uniprot id: A0A2R9AT56
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9597:MIPEP
gene id: 9597:MIPEP
uniprot id: A0A2R9A5P6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9597:ZNF202
gene id: 9597:ZNF202
uniprot id: A0A2R9C7H9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:ZDHHC16
gene id: 9597:ZDHHC16
uniprot id: A0A2R9AAW1
uniprot id: A0A2R9AGG3
uniprot id: A0A2R9AGG7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:LOC100971024
gene id: 9597:LOC100971024
uniprot id: A0A2R9ASA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9597:G6PC2
gene id: 9597:G6PC2
uniprot id: A0A2R9BC93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9597:CHMP1A
gene id: 9597:CHMP1A
uniprot id: A0A2R9AMQ0
names: Similarity
messages: Belongs to the SNF7 family.

9597:DOP1B
gene id: 9597:DOP1B
uniprot id: A0A2R8ZMS1
names: Similarity
messages: Belongs to the dopey family.

9597:SEMA6D
gene id: 9597:SEMA6D
uniprot id: A0A2R9AC21
uniprot id: A0A2R9AC34
uniprot id: A0A2R9AH08
uniprot id: A0A2R9AI10
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CELF3
gene id: 9597:CELF3
uniprot id: A0A2R9BSC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

9597:SMAGP
gene id: 9597:SMAGP
uniprot id: A0A2R9CAH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAGP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9597:BLM
gene id: 9597:BLM
uniprot id: A0A2R9ATE2
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9597:GDPGP1
gene id: 9597:GDPGP1
uniprot id: A0A2R8ZDP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

9597:FMO4
gene id: 9597:FMO4
uniprot id: A0A2R8ZJU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane

9597:PTPN13
gene id: 9597:PTPN13
uniprot id: A0A2R9BND5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
messages: cytoskeleton

9597:SI
gene id: 9597:SI
uniprot id: A0A2R9A1Y1
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:EMP2
gene id: 9597:EMP2
uniprot id: A0A2R8ZMQ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

9597:HMCES
gene id: 9597:HMCES
uniprot id: A0A2R9AB05
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

9597:NUP188
gene id: 9597:NUP188
uniprot id: A0A2R9BL32
names: Subcellular Location Annotation
messages: nuclear pore complex

9597:EFNB2
gene id: 9597:EFNB2
uniprot id: A0A2R9A2R0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:MFSD11
gene id: 9597:MFSD11
uniprot id: A0A2R9CD00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9597:NTRK3
gene id: 9597:NTRK3
uniprot id: A0A2R9CFI2
uniprot id: A0A2R9CFJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9597:RPS19BP1
gene id: 9597:RPS19BP1
uniprot id: A0A2R8ZFJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: nucleolus

9597:OXSR1
gene id: 9597:OXSR1
uniprot id: A0A2R9A1K9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9597:LOC100970104
gene id: 9597:LOC100970104
uniprot id: A0A2R8ZB08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SPSB2
gene id: 9597:SPSB2
uniprot id: A0A2R9B822
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9597:LMX1A
gene id: 9597:LMX1A
uniprot id: A0A2R9ASW8
names: Subcellular Location Annotation
messages: Nucleus

9597:ARHGEF12
gene id: 9597:ARHGEF12
uniprot id: A0A2R9AYK8
uniprot id: A0A2R9AZ06
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9597:RPL31
gene id: 9597:RPL31
uniprot id: A0A2R8ZRE4
uniprot id: A0A2R8ZSL0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9597:HAPLN2
gene id: 9597:HAPLN2
uniprot id: A0A2R9AH74
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100982295
gene id: 9597:LOC100982295
uniprot id: A0A2R8ZMB2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:C11H11orf58
gene id: 9597:C11H11orf58
uniprot id: A0A2R9B475
names: Similarity
messages: Belongs to the SMAP family.

9597:TBL3
gene id: 9597:TBL3
uniprot id: A0A2R9C966
names: Subcellular Location Annotation
messages: nucleolus

9597:ALDH2
gene id: 9597:ALDH2
uniprot id: A0A2R8ZCP2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9597:TXNL4B
gene id: 9597:TXNL4B
uniprot id: A0A2R9ATQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9597:ELOF1
gene id: 9597:ELOF1
uniprot id: A0A2R9BVW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9597:EIF3M
gene id: 9597:EIF3M
uniprot id: A0A2R9A5V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9597:SFMBT2
gene id: 9597:SFMBT2
uniprot id: A0A2R9BTG2
names: Subcellular Location Annotation
messages: Nucleus

9597:PHF5A
gene id: 9597:PHF5A
uniprot id: A0A2R8ZAJ0
names: Similarity
messages: Belongs to the PHF5 family.

9597:TIMM10
gene id: 9597:TIMM10
uniprot id: A0A2R9C369
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9597:LHX2
gene id: 9597:LHX2
uniprot id: A0A2R9AZ03
names: Subcellular Location Annotation
messages: Nucleus

9597:NMD3
gene id: 9597:NMD3
uniprot id: A0A2R9CKL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

9597:BDKRB2
gene id: 9597:BDKRB2
uniprot id: A0A2R9AXX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9597:TMED2
gene id: 9597:TMED2
uniprot id: A0A2R9BB83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9597:PINLYP
gene id: 9597:PINLYP
uniprot id: A0A2R8ZNK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNF-like-inhibitor family.
messages: Secreted

9597:UBAC2
gene id: 9597:UBAC2
uniprot id: A0A2R9A3K3
names: Subcellular Location Annotation
messages: Membrane

9597:KARS1
gene id: 9597:KARS1
uniprot id: A0A2R9BGP9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9597:TMEM35A
gene id: 9597:TMEM35A
uniprot id: A0A2R9CE54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9597:TEKT2
gene id: 9597:TEKT2
uniprot id: A0A2R9ALN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9597:GSTK1
gene id: 9597:GSTK1
uniprot id: A0A2R8ZIL0
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

9597:GSTP1
gene id: 9597:GSTP1
uniprot id: A0A2R9CJA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

9597:DYDC1
gene id: 9597:DYDC1
uniprot id: A0A2R8ZH63
names: Similarity
messages: Belongs to the dpy-30 family.

9597:HTN3
gene id: 9597:HTN3
uniprot id: A0A2R9AZZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Secreted

9597:LOC100988316
gene id: 9597:LOC100988316
uniprot id: A0A2R9BY24
names: Similarity
messages: Belongs to the LEO1 family.

9597:CPVL
gene id: 9597:CPVL
uniprot id: A0A2R9BS66
names: Similarity
messages: Belongs to the peptidase S10 family.

9597:PTEN
gene id: 9597:PTEN
uniprot id: A0A024QYR5
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

9597:LOC100978529
gene id: 9597:LOC100978529
uniprot id: A0A2R9BP16
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9597:CUL2
gene id: 9597:CUL2
uniprot id: A0A2R9BAC0
names: Similarity
messages: Belongs to the cullin family.

9597:SEC11C
gene id: 9597:SEC11C
uniprot id: A0A2R9BF01
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:TSPYL1
gene id: 9597:TSPYL1
uniprot id: A0A2R8ZHP2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9597:IPMK
gene id: 9597:IPMK
uniprot id: A0A2R8ZTN4
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9597:GSG1
gene id: 9597:GSG1
uniprot id: A0A2R9C053
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9597:WLS
gene id: 9597:WLS
uniprot id: A0A2R9AVJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9597:GCH1
gene id: 9597:GCH1
uniprot id: A0A2R9C157
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

9597:SLC1A6
gene id: 9597:SLC1A6
uniprot id: A0A2R9CH68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9597:MINAR2
gene id: 9597:MINAR2
uniprot id: A0A2R9C4E7
names: Similarity
messages: Belongs to the MINAR family.

9597:LSM4
gene id: 9597:LSM4
uniprot id: A0A2R9CTE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9597:NIF3L1
gene id: 9597:NIF3L1
uniprot id: A0A2R9CLA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9597:ZNF605
gene id: 9597:ZNF605
uniprot id: A0A2R8ZY11
names: Function
messages: May be involved in transcriptional regulation.

9597:SST
gene id: 9597:SST
uniprot id: A0A2R8ZYR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9597:LOC100988641
gene id: 9597:LOC100988641
uniprot id: A0A2R9B553
names: Function
messages: May be involved in transcriptional regulation.

9597:MCOLN2
gene id: 9597:MCOLN2
uniprot id: A0A2R9B5J6
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9597:STAB1
gene id: 9597:STAB1
uniprot id: A0A2R9BPI7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:SPOPL
gene id: 9597:SPOPL
uniprot id: A0A2R8Z6S0
names: Similarity
messages: Belongs to the Tdpoz family.

9597:C19H19orf12
gene id: 9597:C19H19orf12
uniprot id: A0A2R9A8G0
uniprot id: A0A2R9A9I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

9597:DYNLT5
gene id: 9597:DYNLT5
uniprot id: A0A2R9CKD8
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9597:DEDD
gene id: 9597:DEDD
uniprot id: A0A2R9A3L7
names: Subcellular Location Annotation
messages: nucleolus

9597:GSX1
gene id: 9597:GSX1
uniprot id: A0A2R9AN76
names: Subcellular Location Annotation
messages: Nucleus

9597:PRKAR2B
gene id: 9597:PRKAR2B
uniprot id: A0A2R8ZUD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9597:ARID1A
gene id: 9597:ARID1A
uniprot id: A0A2R9B7U2
names: Subcellular Location Annotation
messages: Nucleus

9597:DDX5
gene id: 9597:DDX5
uniprot id: A0A2R9CCA6
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9597:JPH3
gene id: 9597:JPH3
uniprot id: A0A2R9C555
uniprot id: A0A2R9C7Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9597:ACE2
gene id: 9597:ACE2
uniprot id: A0A2R9BKD8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9597:MTX3
gene id: 9597:MTX3
uniprot id: A0A2R9C611
uniprot id: A0A2R9C6D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:SLC25A11
gene id: 9597:SLC25A11
uniprot id: A0A2R9C729
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:DDX41
gene id: 9597:DDX41
uniprot id: A0A2R9A779
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.

9597:GALK2
gene id: 9597:GALK2
uniprot id: A0A2R9BVL1
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9597:CTC1
gene id: 9597:CTC1
uniprot id: A0A2R9CCG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9597:ZNF84
gene id: 9597:ZNF84
uniprot id: A0A2R8ZDS5
names: Function
messages: May be involved in transcriptional regulation.

9597:PYCR3
gene id: 9597:PYCR3
uniprot id: A0A2R8ZZF5
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9597:TAGLN2
gene id: 9597:TAGLN2
uniprot id: A0A2R9AVL5
names: Similarity
messages: Belongs to the calponin family.

9597:FAM3A
gene id: 9597:FAM3A
uniprot id: A0A2R9A607
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9597:LOC100985683
gene id: 9597:LOC100985683
uniprot id: A0A2R8ZY13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9597:LOC100978251
gene id: 9597:LOC100978251
uniprot id: A0A2R8Z9X5
uniprot id: A0A2R9BUC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Belongs to the polypeptide deformylase family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

9597:GABRA4
gene id: 9597:GABRA4
uniprot id: A0A2R9C6M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:RPS18
gene id: 9597:RPS18
uniprot id: A0A2R8Z8K8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.

9597:RAB18
gene id: 9597:RAB18
uniprot id: A0A2R9C799
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9597:GAL3ST4
gene id: 9597:GAL3ST4
uniprot id: A0A2R9BPY0
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9597:CFHR5
gene id: 9597:CFHR5
uniprot id: A0A2R9ABK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:PPM1F
gene id: 9597:PPM1F
uniprot id: A0A2R9CLY1
names: Similarity
messages: Belongs to the PP2C family.

9597:TPRG1
gene id: 9597:TPRG1
uniprot id: A0A2R9BYR2
names: Similarity
messages: Belongs to the TPRG1 family.

9597:PCDHB15
gene id: 9597:PCDHB15
uniprot id: A0A2R8ZJT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:ABCG4
gene id: 9597:ABCG4
uniprot id: A0A2R8ZTZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9597:NMUR1
gene id: 9597:NMUR1
uniprot id: A0A2R8ZR68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9597:NDOR1
gene id: 9597:NDOR1
uniprot id: A0A2R9BP41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.
messages: perinuclear region

9597:HAAO
gene id: 9597:HAAO
uniprot id: A0A2R8Z9N2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

9597:LY6G5C
gene id: 9597:LY6G5C
uniprot id: A0A2R9CSZ1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms oligomers.
messages: May have a role in hematopoietic cell differentiation.
messages: Secreted

9597:LOC100977378
gene id: 9597:LOC100977378
uniprot id: A0A2R9BI85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9597:LOC100974786
gene id: 9597:LOC100974786
uniprot id: A0A2R8ZAM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SLC39A4
gene id: 9597:SLC39A4
uniprot id: A0A2R9BKS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9597:IL31RA
gene id: 9597:IL31RA
uniprot id: A0A2R9AHA4
names: Subcellular Location Annotation
messages: Membrane

9597:LSM5
gene id: 9597:LSM5
uniprot id: A0A2R8Z7R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9597:SPTBN2
gene id: 9597:SPTBN2
uniprot id: A0A2R9A0X1
names: Similarity
messages: Belongs to the spectrin family.

9597:POU2F1
gene id: 9597:POU2F1
uniprot id: A0A2R9BCB2
uniprot id: A0A2R9BCB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9597:COL4A6
gene id: 9597:COL4A6
uniprot id: A0A2R8Z6V2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9597:VAT1
gene id: 9597:VAT1
uniprot id: A0A2R9C7T2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9597:GJA5
gene id: 9597:GJA5
uniprot id: A0A2R8ZBI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:ALG2
gene id: 9597:ALG2
uniprot id: A0A2R8ZYD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

9597:CTSH
gene id: 9597:CTSH
uniprot id: A0A2R9C3Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9597:NT5E
gene id: 9597:NT5E
uniprot id: A0A2R9B776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9597:HDAC3
gene id: 9597:HDAC3
uniprot id: A0A2R9BGK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9597:CDC42BPG
gene id: 9597:CDC42BPG
uniprot id: A0A2R9AJ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm

9597:NDUFA3
gene id: 9597:NDUFA3
uniprot id: A0A2R9B995
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9597:TLCD5
gene id: 9597:TLCD5
uniprot id: A0A2R8ZP20
names: Subcellular Location Annotation
messages: Membrane

9597:SLC13A5
gene id: 9597:SLC13A5
uniprot id: A0A2R9CKV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9597:RRAGA
gene id: 9597:RRAGA
uniprot id: A0A2R8ZGS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9597:SPDYE4
gene id: 9597:SPDYE4
uniprot id: A0A2R9CIC7
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9597:GALNT6
gene id: 9597:GALNT6
uniprot id: A0A2R9AQX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9597:ARK2N
gene id: 9597:ARK2N
uniprot id: A0A2R9B092
uniprot id: A0A2R9B0G9
names: Subcellular Location Annotation
messages: Nucleus

9597:FXN
gene id: 9597:FXN
uniprot id: A0A2R9BWG5
names: Similarity
messages: Belongs to the frataxin family.

9597:PTK2B
gene id: 9597:PTK2B
uniprot id: A0A2R9BL74
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9597:TIPRL
gene id: 9597:TIPRL
uniprot id: A0A2R9C8P4
names: Similarity
messages: Belongs to the TIP41 family.

9597:SLC6A12
gene id: 9597:SLC6A12
uniprot id: A0A2R8Z8I0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Cell membrane
messages: Interacts with LIN7C.
messages: Lateral cell membrane
messages: Membrane

9597:CASS4
gene id: 9597:CASS4
uniprot id: A0A2R8Z6A9
names: Similarity
messages: Belongs to the CAS family.

9597:LOC100978392
gene id: 9597:LOC100978392
uniprot id: A0A2R9A6L2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9597:MAB21L2
gene id: 9597:MAB21L2
uniprot id: A0A2R8ZMH1
names: Similarity
messages: Belongs to the mab-21 family.

9597:ITGA8
gene id: 9597:ITGA8
uniprot id: A0A2R9AJX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:KATNAL1
gene id: 9597:KATNAL1
uniprot id: A0A2R9ATJ5
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9597:SGIP1
gene id: 9597:SGIP1
uniprot id: A0A2R9C7T5
names: Function
names: Subcellular Location Annotation
messages: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
messages: clathrin-coated pit

9597:TUBA8
gene id: 9597:TUBA8
uniprot id: A0A2R9AU66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9597:CYP27A1
gene id: 9597:CYP27A1
uniprot id: A0A2R9CKX8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:CREB5
gene id: 9597:CREB5
uniprot id: A0A2R9ACK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
messages: Binds to the cAMP response element and activates transcription.
messages: Nucleus

9597:GFRA3
gene id: 9597:GFRA3
uniprot id: A0A2R9CCY9
names: Similarity
messages: Belongs to the GDNFR family.

9597:SMAD2
gene id: 9597:SMAD2
uniprot id: A0A2R9B4S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9597:CENPX
gene id: 9597:CENPX
uniprot id: A0A2R9A6P0
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

9597:UNC119B
gene id: 9597:UNC119B
uniprot id: A0A2R9CPV0
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9597:WNT11
gene id: 9597:WNT11
uniprot id: A0A2R8ZIH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:PPA1
gene id: 9597:PPA1
uniprot id: A0A2R9AJJ7
names: Similarity
messages: Belongs to the PPase family.

9597:BOLA3
gene id: 9597:BOLA3
uniprot id: A0A2R9BV74
names: Similarity
messages: Belongs to the BolA/IbaG family.

9597:MCIDAS
gene id: 9597:MCIDAS
uniprot id: A0A2R9B0E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9597:DTNBP1
gene id: 9597:DTNBP1
uniprot id: A0A2R9BPE4
uniprot id: A0A2R9BQ16
names: Similarity
messages: Belongs to the dysbindin family.

9597:LOC100989095
gene id: 9597:LOC100989095
uniprot id: A0A2R8ZAN6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:UCKL1
gene id: 9597:UCKL1
uniprot id: A0A2R9BQC6
names: Similarity
messages: Belongs to the uridine kinase family.

9597:EIF2B2
gene id: 9597:EIF2B2
uniprot id: A0A2R9AGX7
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9597:NIT2
gene id: 9597:NIT2
uniprot id: A0A2R9A3D8
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9597:MRPL42
gene id: 9597:MRPL42
uniprot id: A0A2R9BLQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9597:CA14
gene id: 9597:CA14
uniprot id: A0A2R9A052
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9597:LOC100973858
gene id: 9597:LOC100973858
uniprot id: A0A2R9BU98
names: Similarity
messages: Belongs to the intermediate filament family.

9597:PRIMPOL
gene id: 9597:PRIMPOL
uniprot id: A0A2R9BM03
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9597:RWDD3
gene id: 9597:RWDD3
uniprot id: A0A2R8ZTP1
uniprot id: A0A2R8ZUW1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:SPEM2
gene id: 9597:SPEM2
uniprot id: A0A2R9BV75
names: Subcellular Location Annotation
messages: Membrane

9597:MARCHF4
gene id: 9597:MARCHF4
uniprot id: A0A2R9B6S4
names: Subcellular Location Annotation
messages: Membrane

9597:KCNJ13
gene id: 9597:KCNJ13
uniprot id: A0A2R9AFS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9597:HIRIP3
gene id: 9597:HIRIP3
uniprot id: A0A2R8Z920
names: Subcellular Location Annotation
messages: Nucleus

9597:RFC4
gene id: 9597:RFC4
uniprot id: A0A2R9C3P2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9597:TAS2R1
gene id: 9597:TAS2R1
uniprot id: Q646G9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:ELF3
gene id: 9597:ELF3
uniprot id: A0A2R9B6Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:HOGA1
gene id: 9597:HOGA1
uniprot id: A0A2R8ZPI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9597:NEU2
gene id: 9597:NEU2
uniprot id: A0A2R9BJ98
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9597:LOC100992828
gene id: 9597:LOC100992828
uniprot id: A0A2R8ZCH9
names: Similarity
messages: Belongs to the MIF family.

9597:GBP6
gene id: 9597:GBP6
uniprot id: A0A2R9B0K8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9597:TNFRSF8
gene id: 9597:TNFRSF8
uniprot id: A0A2R9AXI5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CCNE2
gene id: 9597:CCNE2
uniprot id: A0A2R9A0P4
names: Similarity
messages: Belongs to the cyclin family.

9597:METTL15
gene id: 9597:METTL15
uniprot id: A0A2R9A2C6
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9597:RAD9B
gene id: 9597:RAD9B
uniprot id: A0A2R8Z9Z3
names: Similarity
messages: Belongs to the rad9 family.

9597:PON1
gene id: 9597:PON1
uniprot id: A0A2R9BCI1
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9597:KDM4C
gene id: 9597:KDM4C
uniprot id: A0A2R9CC08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9597:INTS3
gene id: 9597:INTS3
uniprot id: A0A2R9B031
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

9597:ZNF397
gene id: 9597:ZNF397
uniprot id: A0A2R9C8P1
names: Subcellular Location Annotation
messages: Nucleus

9597:NANOG
gene id: 9597:NANOG
uniprot id: A0A2R8ZE61
names: Subcellular Location Annotation
messages: Nucleus

9597:FAM187B
gene id: 9597:FAM187B
uniprot id: A0A2R8ZEG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9597:MUL1
gene id: 9597:MUL1
uniprot id: A0A2R9AQV9
names: Subcellular Location Annotation
messages: Membrane

9597:LOXL3
gene id: 9597:LOXL3
uniprot id: A0A2R8ZPE4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9597:IL1A
gene id: 9597:IL1A
uniprot id: A0A2R9AMR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Secreted

9597:SPAG7
gene id: 9597:SPAG7
uniprot id: A0A2R9BWI5
names: Subcellular Location Annotation
messages: Nucleus

9597:SEPTIN11
gene id: 9597:SEPTIN11
uniprot id: A0A2R9CAW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9597:WNT5B
gene id: 9597:WNT5B
uniprot id: A0A2R8ZJI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:FUT11
gene id: 9597:FUT11
uniprot id: A0A2R9AWC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9597:IL26
gene id: 9597:IL26
uniprot id: A0A2R9ADA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9597:TFPI2
gene id: 9597:TFPI2
uniprot id: A0A2R8ZVX2
names: Subcellular Location Annotation
messages: Secreted

9597:C2BH2orf76
gene id: 9597:C2BH2orf76
uniprot id: A0A2R9CI96
names: Similarity
messages: Belongs to the UPF0538 family.

9597:ETV2
gene id: 9597:ETV2
uniprot id: A0A2R9BNU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:LTF
gene id: 9597:LTF
uniprot id: A0A161IL64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferrin family.
messages: Cytoplasmic granule
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.

9597:MRPL23
gene id: 9597:MRPL23
uniprot id: A0A2R9AYS2
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9597:CTBS
gene id: 9597:CTBS
uniprot id: A0A2R9C459
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Lysosome

9597:DERL3
gene id: 9597:DERL3
uniprot id: A0A2R9A1B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9597:B3GNT2
gene id: 9597:B3GNT2
uniprot id: A0A2R8ZMJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:PPP1R15B
gene id: 9597:PPP1R15B
uniprot id: A0A2R9BET9
names: Similarity
messages: Belongs to the PPP1R15 family.

9597:REXO4
gene id: 9597:REXO4
uniprot id: A0A2R8ZWM2
names: Similarity
messages: Belongs to the REXO4 family.

9597:SEMA3C
gene id: 9597:SEMA3C
uniprot id: A0A2R9CG16
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:LOC100984808
gene id: 9597:LOC100984808
uniprot id: A0A2R8ZQT5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:FXYD3
gene id: 9597:FXYD3
uniprot id: A0A2R8ZHG9
names: Similarity
messages: Belongs to the FXYD family.

9597:SLC35D1
gene id: 9597:SLC35D1
uniprot id: A0A2R8ZT85
names: Subcellular Location Annotation
messages: Membrane

9597:TACSTD2
gene id: 9597:TACSTD2
uniprot id: A0A2R8ZC40
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:TMEM9
gene id: 9597:TMEM9
uniprot id: A0A2R9BPC8
names: Similarity
messages: Belongs to the TMEM9 family.

9597:ERCC3
gene id: 9597:ERCC3
uniprot id: A0A2R9B901
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

9597:LOC100969035
gene id: 9597:LOC100969035
uniprot id: A0A2R8ZB40
names: Similarity
messages: Belongs to the pro/parathymosin family.

9597:TMEM63A
gene id: 9597:TMEM63A
uniprot id: A0A2R9B2E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9597:ATP6V0E1
gene id: 9597:ATP6V0E1
uniprot id: A0A2R9BNP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9597:CFAP97
gene id: 9597:CFAP97
uniprot id: A0A2R9A6I1
names: Similarity
messages: Belongs to the CFAP97 family.

9597:UVSSA
gene id: 9597:UVSSA
uniprot id: A0A2R9C1F3
names: Similarity
messages: Belongs to the UVSSA family.

9597:VPS13A
gene id: 9597:VPS13A
uniprot id: A0A2R8Z9J5
uniprot id: A0A2R8ZDI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

9597:IWS1
gene id: 9597:IWS1
uniprot id: A0A2R9C5I5
names: Subcellular Location Annotation
messages: Nucleus

9597:LCK
gene id: 9597:LCK
uniprot id: A0A2R9AKH9
uniprot id: A0A2R9AKJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9597:DSC2
gene id: 9597:DSC2
uniprot id: A0A2R9BEU8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9597:SLC22A18
gene id: 9597:SLC22A18
uniprot id: A0A2R9AMW0
names: Subcellular Location Annotation
messages: Membrane

9597:DIS3L2
gene id: 9597:DIS3L2
uniprot id: A0A2R9ALF7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cytoplasm
messages: P-body
messages: Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.

9597:SSRP1
gene id: 9597:SSRP1
uniprot id: A0A2R9BSX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

9597:CMKLR1
gene id: 9597:CMKLR1
uniprot id: A0A2R9AM00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9597:GPR107
gene id: 9597:GPR107
uniprot id: A0A2R9AI35
uniprot id: A0A2R9AMV1
names: Subcellular Location Annotation
messages: Membrane

9597:TMEM41A
gene id: 9597:TMEM41A
uniprot id: A0A2R9A2L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9597:MPP2
gene id: 9597:MPP2
uniprot id: A0A2R9B1M1
uniprot id: A0A2R9B1S9
names: Similarity
messages: Belongs to the MAGUK family.

9597:MUC13
gene id: 9597:MUC13
uniprot id: A0A2R9BYZ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:DHRS7C
gene id: 9597:DHRS7C
uniprot id: A0A2R9A4E4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:CXCL10
gene id: 9597:CXCL10
uniprot id: A0A2R9BLR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:CDC26
gene id: 9597:CDC26
uniprot id: A0A2R9B2U5
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9597:FREM2
gene id: 9597:FREM2
uniprot id: A0A2R9AXU3
names: Similarity
messages: Belongs to the FRAS1 family.

9597:B3GNT4
gene id: 9597:B3GNT4
uniprot id: A0A2R9BTS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:MEGF8
gene id: 9597:MEGF8
uniprot id: A0A2R8ZUW9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:CDX4
gene id: 9597:CDX4
uniprot id: A0A2R9BDJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9597:LOC100989331
gene id: 9597:LOC100989331
uniprot id: A0A2R8ZP44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:NDUFC1
gene id: 9597:NDUFC1
uniprot id: A0A2R9BE82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:SRXN1
gene id: 9597:SRXN1
uniprot id: A0A2R9AHS2
names: Similarity
messages: Belongs to the sulfiredoxin family.

9597:VTA1
gene id: 9597:VTA1
uniprot id: A0A2R9A2S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9597:BAK1
gene id: 9597:BAK1
uniprot id: A0A2R9A7S4
names: Similarity
messages: Belongs to the Bcl-2 family.

9597:TMEM245
gene id: 9597:TMEM245
uniprot id: A0A2R9CCB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

9597:PGPEP1
gene id: 9597:PGPEP1
uniprot id: A0A2R9ABG4
uniprot id: A0A2R9ABG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

9597:TARS1
gene id: 9597:TARS1
uniprot id: A0A2R8ZJH6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9597:GTPBP3
gene id: 9597:GTPBP3
uniprot id: A0A2R8ZUU2
uniprot id: A0A2R8ZVY6
uniprot id: A0A2R8ZVZ0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

9597:DNAJC27
gene id: 9597:DNAJC27
uniprot id: A0A2R9ANF0
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9597:VAPB
gene id: 9597:VAPB
uniprot id: A0A2R9AZ86
uniprot id: A0A2R9B5E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:GPR119
gene id: 9597:GPR119
uniprot id: A0A2R8ZEY9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:C5H5orf22
gene id: 9597:C5H5orf22
uniprot id: A0A2R9A9A3
names: Similarity
messages: Belongs to the UPF0489 family.

9597:TPT1
gene id: 9597:TPT1
uniprot id: A0A2R9CBI8
names: Similarity
messages: Belongs to the TCTP family.

9597:BZW2
gene id: 9597:BZW2
uniprot id: A0A2R9A7N8
names: Similarity
messages: Belongs to the BZW family.

9597:NFE2
gene id: 9597:NFE2
uniprot id: A0A2R8ZQP3
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9597:MAPKAP1
gene id: 9597:MAPKAP1
uniprot id: A0A2R9BSF5
uniprot id: A0A2R9BSK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIN1 family.
messages: Cytoplasmic vesicle

9597:LANCL3
gene id: 9597:LANCL3
uniprot id: A0A2R8ZYM5
names: Similarity
messages: Belongs to the LanC-like protein family.

9597:NDUFS4
gene id: 9597:NDUFS4
uniprot id: A0A2R9ANH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

9597:PDSS2
gene id: 9597:PDSS2
uniprot id: A0A2R9BBJ7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9597:LOC100969609
gene id: 9597:LOC100969609
uniprot id: A0A2R9AVQ7
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9597:CYP4A22
gene id: 9597:CYP4A22
uniprot id: A0A2R9AE72
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:ZNF8
gene id: 9597:ZNF8
uniprot id: A0A2R9A750
names: Function
messages: May be involved in transcriptional regulation.

9597:TXN
gene id: 9597:TXN
uniprot id: A0A2R9CE55
names: Similarity
messages: Belongs to the thioredoxin family.

9597:NOSIP
gene id: 9597:NOSIP
uniprot id: A0A2R9AWT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

9597:CLTA
gene id: 9597:CLTA
uniprot id: A0A2R9C0H6
uniprot id: A0A2R9C339
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9597:TMC6
gene id: 9597:TMC6
uniprot id: A0A2R8ZR91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9597:L3HYPDH
gene id: 9597:L3HYPDH
uniprot id: A0A2R9BWA8
names: Similarity
messages: Belongs to the proline racemase family.

9597:ALX1
gene id: 9597:ALX1
uniprot id: A0A2R9B0M3
names: Subcellular Location Annotation
messages: Nucleus

9597:MYBL2
gene id: 9597:MYBL2
uniprot id: A0A2R9CF52
names: Subcellular Location Annotation
messages: Nucleus

9597:APOA4
gene id: 9597:APOA4
uniprot id: A0A2R9BIY1
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9597:SMAD7
gene id: 9597:SMAD7
uniprot id: A0A2R9AGA7
names: Subcellular Location Annotation
messages: Nucleus

9597:RPS14
gene id: 9597:RPS14
uniprot id: A0A2R8ZV22
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9597:EXOC6B
gene id: 9597:EXOC6B
uniprot id: A0A2R8ZJV0
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9597:VPS26B
gene id: 9597:VPS26B
uniprot id: A0A2R8ZW95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9597:CYP27B1
gene id: 9597:CYP27B1
uniprot id: A0A2R9ALD4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:UBE2B
gene id: 9597:UBE2B
uniprot id: A0A2R9BYP7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9597:LHX5
gene id: 9597:LHX5
uniprot id: A0A2R9B0Q4
names: Subcellular Location Annotation
messages: Nucleus

9597:PTPRM
gene id: 9597:PTPRM
uniprot id: A0A2R8ZLI9
uniprot id: A0A2R8ZRJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9597:PSMD11
gene id: 9597:PSMD11
uniprot id: A0A2R9CMB9
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

9597:LOC100967520
gene id: 9597:LOC100967520
uniprot id: A0A2R9AY06
uniprot id: A0A2R9B3E8
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: May be involved in transcriptional regulation.

9597:AP1S3
gene id: 9597:AP1S3
uniprot id: A0A2R9CBP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9597:TIMM17A
gene id: 9597:TIMM17A
uniprot id: A0A2R8ZTT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9597:ARRDC4
gene id: 9597:ARRDC4
uniprot id: A0A2R9BXP8
names: Similarity
messages: Belongs to the arrestin family.

9597:HOXC10
gene id: 9597:HOXC10
uniprot id: A0A2R9B7Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9597:CRB1
gene id: 9597:CRB1
uniprot id: A0A2R9BCU6
uniprot id: A0A2R9BGM6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TRIM54
gene id: 9597:TRIM54
uniprot id: A0A2R9BCG1
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9597:GTF2H1
gene id: 9597:GTF2H1
uniprot id: A0A2R9A8M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9597:GDE1
gene id: 9597:GDE1
uniprot id: A0A2R9AFK3
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9597:VAX1
gene id: 9597:VAX1
uniprot id: A0A2R9A8I6
names: Subcellular Location Annotation
messages: Nucleus

9597:ADAM2
gene id: 9597:ADAM2
uniprot id: A0A2R9A1V7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:PUS7L
gene id: 9597:PUS7L
uniprot id: A0A2R9CDC6
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9597:NMNAT2
gene id: 9597:NMNAT2
uniprot id: A0A2R8ZV83
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9597:IGF2BP1
gene id: 9597:IGF2BP1
uniprot id: A0A2R9C8U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9597:FASLG
gene id: 9597:FASLG
uniprot id: A0A2R9A5R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9597:CDC37L1
gene id: 9597:CDC37L1
uniprot id: A0A2R9BNV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9597:TSHZ3
gene id: 9597:TSHZ3
uniprot id: A0A2R9BA29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

9597:COG3
gene id: 9597:COG3
uniprot id: A0A2R9AUL1
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9597:FAM76B
gene id: 9597:FAM76B
uniprot id: A0A2R9AQT7
names: Similarity
messages: Belongs to the FAM76 family.

9597:FA2H
gene id: 9597:FA2H
uniprot id: A0A2R8ZJK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:GBF1
gene id: 9597:GBF1
uniprot id: A0A2R9CF35
names: Subcellular Location Annotation
messages: Golgi apparatus

9597:TAS2R16
gene id: 9597:TAS2R16
uniprot id: Q646D1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Cell membrane
messages: Interacts with RTP3 and RTP4.
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9597:CHRNA6
gene id: 9597:CHRNA6
uniprot id: A0A2R9BF04
uniprot id: A0A2R9BIW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:TASOR2
gene id: 9597:TASOR2
uniprot id: A0A2R9A7W7
names: Similarity
messages: Belongs to the TASOR family.

9597:MAP2K6
gene id: 9597:MAP2K6
uniprot id: A0A2R9BGH1
uniprot id: A0A2R9BHG8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:DYDC2
gene id: 9597:DYDC2
uniprot id: A0A2R9BBM7
names: Similarity
messages: Belongs to the dpy-30 family.

9597:NRN1
gene id: 9597:NRN1
uniprot id: A0A2R9C746
names: Similarity
messages: Belongs to the neuritin family.

9597:HPS6
gene id: 9597:HPS6
uniprot id: A0A2R8ZCG4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

9597:PIK3C3
gene id: 9597:PIK3C3
uniprot id: A0A2R9AAE5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9597:PRKX
gene id: 9597:PRKX
uniprot id: A0A2R9CL70
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:IL1B
gene id: 9597:IL1B
uniprot id: A0A2R9BYV3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9597:CHURC1
gene id: 9597:CHURC1
uniprot id: A0A2R9CGZ1
uniprot id: A0A2R9CQT7
names: Similarity
messages: Belongs to the Churchill family.

9597:PDSS1
gene id: 9597:PDSS1
uniprot id: A0A2R8ZSC1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9597:CDIPT
gene id: 9597:CDIPT
uniprot id: A0A2R9C1W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9597:ABCB6
gene id: 9597:ABCB6
uniprot id: A0A2R9AJX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: extracellular exosome
messages: multivesicular body membrane

9597:HYAL1
gene id: 9597:HYAL1
uniprot id: A0A2R9BIQ0
uniprot id: A0A2R9BRK8
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9597:EDC3
gene id: 9597:EDC3
uniprot id: A0A2R9C828
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9597:LOC129392920
gene id: 9597:LOC129392920
uniprot id: A0A2R9A427
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9597:ZNF503
gene id: 9597:ZNF503
uniprot id: A0A2R8Z5P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

9597:NLGN3
gene id: 9597:NLGN3
uniprot id: A0A2R9A3K6
uniprot id: A0A2R9A705
uniprot id: A0A2R9A7T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9597:LAMC2
gene id: 9597:LAMC2
uniprot id: A0A2R9B9I9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9597:HSF4
gene id: 9597:HSF4
uniprot id: A0A2R9BGS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9597:CYP3A5
gene id: 9597:CYP3A5
uniprot id: A0A2R9BZX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9597:MAK16
gene id: 9597:MAK16
uniprot id: A0A2R9B4H0
names: Similarity
messages: Belongs to the MAK16 family.

9597:DPEP1
gene id: 9597:DPEP1
uniprot id: A0A2R9AKL5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

9597:LCLAT1
gene id: 9597:LCLAT1
uniprot id: A0A2R8ZVQ4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9597:ASPA
gene id: 9597:ASPA
uniprot id: A0A2R9C417
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9597:PLK4
gene id: 9597:PLK4
uniprot id: A0A2R9AC53
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: centriole

9597:LOC100978202
gene id: 9597:LOC100978202
uniprot id: A0A2R9ABQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9597:SUMO1
gene id: 9597:SUMO1
uniprot id: A0A2R9BUH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9597:ZIC4
gene id: 9597:ZIC4
uniprot id: A0A2R9BGI1
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9597:ARHGEF3
gene id: 9597:ARHGEF3
uniprot id: A0A2R9BM68
uniprot id: A0A2R9BN46
uniprot id: A0A2R9BQT6
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9597:SERPINF2
gene id: 9597:SERPINF2
uniprot id: A0A2R9BXC9
names: Similarity
messages: Belongs to the serpin family.

9597:MDFI
gene id: 9597:MDFI
uniprot id: A0A2R9BNA6
names: Similarity
messages: Belongs to the MDFI family.

9597:N6AMT1
gene id: 9597:N6AMT1
uniprot id: A0A2R9B519
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

9597:TUB
gene id: 9597:TUB
uniprot id: A0A2R9APF1
uniprot id: A0A2R9AW96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9597:ZNF670
gene id: 9597:ZNF670
uniprot id: A0A2R9CAD1
names: Function
messages: May be involved in transcriptional regulation.

9597:PRND
gene id: 9597:PRND
uniprot id: A0A2R8ZAS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9597:PPAT
gene id: 9597:PPAT
uniprot id: A0A2R9C821
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9597:TRAF5
gene id: 9597:TRAF5
uniprot id: A0A2R9AKW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9597:GFUS
gene id: 9597:GFUS
uniprot id: A0A2R9A8H5
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9597:GGA3
gene id: 9597:GGA3
uniprot id: A0A2R9A587
uniprot id: A0A2R9AAJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9597:TMEM45A
gene id: 9597:TMEM45A
uniprot id: A0A2R9ASW0
uniprot id: A0A2R9ASW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9597:ACTL8
gene id: 9597:ACTL8
uniprot id: A0A2R9AUX3
names: Similarity
messages: Belongs to the actin family.

9597:CCL1
gene id: 9597:CCL1
uniprot id: A0A2R8Z7Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9597:CNDP2
gene id: 9597:CNDP2
uniprot id: A0A2R9C0F8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9597:LYPLA2
gene id: 9597:LYPLA2
uniprot id: A0A2R8ZLB5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9597:NKX3-2
gene id: 9597:NKX3-2
uniprot id: A0A2R9BUW0
names: Subcellular Location Annotation
messages: Nucleus

9597:HADHB
gene id: 9597:HADHB
uniprot id: A0A2R9CD86
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9597:CA13
gene id: 9597:CA13
uniprot id: A0A2R9AZC3
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9597:LHFPL2
gene id: 9597:LHFPL2
uniprot id: A0A2R9BM39
names: Subcellular Location Annotation
messages: Membrane

9597:SMIM8
gene id: 9597:SMIM8
uniprot id: A0A2R8ZBC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9597:SMARCA5
gene id: 9597:SMARCA5
uniprot id: A0A2R9A065
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9597:GPN2
gene id: 9597:GPN2
uniprot id: A0A2R9BVZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9597:SLC25A40
gene id: 9597:SLC25A40
uniprot id: A0A2R9CIG5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9597:NMU
gene id: 9597:NMU
uniprot id: A0A2R9BKV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9597:IFT70B
gene id: 9597:IFT70B
uniprot id: A0A2R8ZI23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9597:EIF1AD
gene id: 9597:EIF1AD
uniprot id: A0A2R8Z714
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9597:DSG3
gene id: 9597:DSG3
uniprot id: A0A2R9C2V7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9597:KRT13
gene id: 9597:KRT13
uniprot id: A0A2R8ZB46
uniprot id: A0A2R8ZHV6
names: Similarity
messages: Belongs to the intermediate filament family.

9597:CPA3
gene id: 9597:CPA3
uniprot id: A0A2R9CLS4
names: Similarity
messages: Belongs to the peptidase M14 family.

9597:TM6SF2
gene id: 9597:TM6SF2
uniprot id: A0A2R9CIK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

9597:GCNT2
gene id: 9597:GCNT2
uniprot id: A0A2R9C5N5
uniprot id: A0A2R9C5P1
uniprot id: A0A2R9C5P6
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9597:VIPAS39
gene id: 9597:VIPAS39
uniprot id: A0A2R9B1T3
uniprot id: A0A2R9B5K9
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9597:IARS1
gene id: 9597:IARS1
uniprot id: A0A2R8ZZI5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:LOC100968283
gene id: 9597:LOC100968283
uniprot id: A0A2R9ASE2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:CDC42SE2
gene id: 9597:CDC42SE2
uniprot id: A0A2R9AGB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9597:DOCK5
gene id: 9597:DOCK5
uniprot id: A0A2R9C3Y7
names: Similarity
messages: Belongs to the DOCK family.

9597:ABCG2
gene id: 9597:ABCG2
uniprot id: A0A2R8ZM79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9597:NLRP9
gene id: 9597:NLRP9
uniprot id: A0A2R9CN71
names: Similarity
messages: Belongs to the NLRP family.

9597:ID3
gene id: 9597:ID3
uniprot id: A0A2R8ZC46
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100986475
gene id: 9597:LOC100986475
uniprot id: A0A2R9C247
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:LOC100985441
gene id: 9597:LOC100985441
uniprot id: A0A2R8ZBN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:RTF2
gene id: 9597:RTF2
uniprot id: A0A2R8ZSA9
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9597:PNPLA7
gene id: 9597:PNPLA7
uniprot id: A0A2R9AT02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:RPS13
gene id: 9597:RPS13
uniprot id: A0A2R9BWG0
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9597:SERINC5
gene id: 9597:SERINC5
uniprot id: A0A2R9BWY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9597:SPAM1
gene id: 9597:SPAM1
uniprot id: A0A2R8Z9G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9597:PIM2
gene id: 9597:PIM2
uniprot id: A0A2R9C4I5
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9597:ATP6V1G2
gene id: 9597:ATP6V1G2
uniprot id: A0A2R9AQA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9597:HBQ1
gene id: 9597:HBQ1
uniprot id: A0A2R9BK37
names: Similarity
messages: Belongs to the globin family.

9597:BDH1
gene id: 9597:BDH1
uniprot id: A0A2R9AZ51
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:LOC100970998
gene id: 9597:LOC100970998
uniprot id: A0A2R8Z7P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9597:ADAMTS4
gene id: 9597:ADAMTS4
uniprot id: A0A2R9CI30
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:TSPAN12
gene id: 9597:TSPAN12
uniprot id: A0A2R9AU53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:TSSK6
gene id: 9597:TSSK6
uniprot id: A0A2R8ZN56
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:CHAC1
gene id: 9597:CHAC1
uniprot id: A0A2R9BYH5
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9597:APLNR
gene id: 9597:APLNR
uniprot id: A0A2R8Z9F6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:LOC100988550
gene id: 9597:LOC100988550
uniprot id: A0A2R9CAA2
uniprot id: A0A2R9CAH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9597:LOC100969587
gene id: 9597:LOC100969587
uniprot id: A0A2R8ZKU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:USP5
gene id: 9597:USP5
uniprot id: A0A2R9BK98
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9597:RPL6
gene id: 9597:RPL6
uniprot id: A0A2R8ZAQ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9597:ZNF18
gene id: 9597:ZNF18
uniprot id: A0A2R9AE09
uniprot id: A0A2R9AHY7
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:IFI6
gene id: 9597:IFI6
uniprot id: A0A2R9AKP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9597:PGAM2
gene id: 9597:PGAM2
uniprot id: A0A2R9AXF5
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9597:BTF3
gene id: 9597:BTF3
uniprot id: A0A2R8ZPJ0
names: Similarity
messages: Belongs to the NAC-beta family.

9597:METTL26
gene id: 9597:METTL26
uniprot id: A0A2R9BH99
uniprot id: A0A2R9BHA3
names: Similarity
messages: Belongs to the UPF0585 family.

9597:CLDN17
gene id: 9597:CLDN17
uniprot id: A0A2R9AVC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:PRLR
gene id: 9597:PRLR
uniprot id: A0A2R9CSZ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9597:POLR3D
gene id: 9597:POLR3D
uniprot id: A0A2R9A6A7
names: Subcellular Location Annotation
messages: Nucleus

9597:TEX13A
gene id: 9597:TEX13A
uniprot id: A0A2R9CLL4
names: Similarity
messages: Belongs to the TEX13 family.

9597:PYM1
gene id: 9597:PYM1
uniprot id: A0A2R9CJC7
uniprot id: A0A2R9CJF1
names: Similarity
names: Subunit
messages: Belongs to the pym family.
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

9597:PHOSPHO1
gene id: 9597:PHOSPHO1
uniprot id: A0A2R9CFT9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9597:SLC7A1
gene id: 9597:SLC7A1
uniprot id: A0A2R9BE45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9597:ASPHD1
gene id: 9597:ASPHD1
uniprot id: A0A2R9B2F1
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9597:FADS2
gene id: 9597:FADS2
uniprot id: A0A2R9BKZ6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:SND1
gene id: 9597:SND1
uniprot id: A0A2R9CFY9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9597:SPCS1
gene id: 9597:SPCS1
uniprot id: A0A2R9AZM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:THEMIS
gene id: 9597:THEMIS
uniprot id: A0A2R9AW99
names: Similarity
messages: Belongs to the themis family.

9597:COQ5
gene id: 9597:COQ5
uniprot id: A0A2R9A7V4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9597:ZNF214
gene id: 9597:ZNF214
uniprot id: A0A2R9BNJ0
names: Function
messages: May be involved in transcriptional regulation.

9597:TSPYL6
gene id: 9597:TSPYL6
uniprot id: A0A2R8ZHA4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9597:PITPNM3
gene id: 9597:PITPNM3
uniprot id: A0A2R8ZX56
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9597:DKK3
gene id: 9597:DKK3
uniprot id: A0A2R9C8R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9597:MED20
gene id: 9597:MED20
uniprot id: A0A2R9AU31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:APOD
gene id: 9597:APOD
uniprot id: A0A2R9AZL2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Homodimer.
messages: Secreted

9597:ESYT1
gene id: 9597:ESYT1
uniprot id: A0A2R9B1G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:USP16
gene id: 9597:USP16
uniprot id: A0A2R8ZKJ4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9597:ZNF212
gene id: 9597:ZNF212
uniprot id: A0A2R9CAE0
names: Function
messages: May be involved in transcriptional regulation.

9597:TNS1
gene id: 9597:TNS1
uniprot id: A0A2R9C5B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9597:LOC100973465
gene id: 9597:LOC100973465
uniprot id: A0A2R9BUA8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:AP4S1
gene id: 9597:AP4S1
uniprot id: A0A2R9C6K9
uniprot id: A0A2R9C6L8
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9597:NAPEPLD
gene id: 9597:NAPEPLD
uniprot id: A0A2R9BCK2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

9597:ACTR1B
gene id: 9597:ACTR1B
uniprot id: A0A2R8ZL16
names: Similarity
messages: Belongs to the actin family.

9597:APOL2
gene id: 9597:APOL2
uniprot id: A0A2R9BS79
names: Similarity
messages: Belongs to the apolipoprotein L family.

9597:MGA
gene id: 9597:MGA
uniprot id: A0A2R9B6R6
uniprot id: A0A2R9B6S2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:MFSD10
gene id: 9597:MFSD10
uniprot id: A0A2R9C7J9
names: Subcellular Location Annotation
messages: Membrane

9597:OSGEP
gene id: 9597:OSGEP
uniprot id: A0A2R8ZJ76
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleus

9597:GLA
gene id: 9597:GLA
uniprot id: A0A2R9A2F5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9597:GFM1
gene id: 9597:GFM1
uniprot id: A0A2R9AW37
uniprot id: A0A2R9B001
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9597:CRAT
gene id: 9597:CRAT
uniprot id: A0A2R8ZEK7
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9597:MYF6
gene id: 9597:MYF6
uniprot id: A0A2R9ALT9
names: Subcellular Location Annotation
messages: Nucleus

9597:SOD3
gene id: 9597:SOD3
uniprot id: A0A2R8ZNC2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

9597:LTBP4
gene id: 9597:LTBP4
uniprot id: A0A2R9A9D5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:KRT6A
gene id: 9597:KRT6A
uniprot id: A0A2R9B125
names: Similarity
messages: Belongs to the intermediate filament family.

9597:ASB1
gene id: 9597:ASB1
uniprot id: A0A2R9BHF6
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9597:ELP2
gene id: 9597:ELP2
uniprot id: A0A2R9A8V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

9597:RARS1
gene id: 9597:RARS1
uniprot id: A0A2R9CLD1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:LGI3
gene id: 9597:LGI3
uniprot id: A0A2R9BDE6
names: Subcellular Location Annotation
messages: Secreted

9597:LOC100971948
gene id: 9597:LOC100971948
uniprot id: A0A2R9ALK8
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9597:ATP5F1C
gene id: 9597:ATP5F1C
uniprot id: A0A2R8Z9T1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9597:SLC5A4
gene id: 9597:SLC5A4
uniprot id: A0A2R8ZK16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9597:SGK2
gene id: 9597:SGK2
uniprot id: A0A2R9AH57
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:TNKS
gene id: 9597:TNKS
uniprot id: A0A2R9A9V7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:STX12
gene id: 9597:STX12
uniprot id: A0A2R9C5C2
names: Similarity
messages: Belongs to the syntaxin family.

9597:ARSA
gene id: 9597:ARSA
uniprot id: A0A2R8ZGT3
names: Similarity
messages: Belongs to the sulfatase family.

9597:CDC37
gene id: 9597:CDC37
uniprot id: A0A2R9C7D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9597:SYNJ1
gene id: 9597:SYNJ1
uniprot id: A0A2R8ZRH4
uniprot id: A0A2R8ZRH7
uniprot id: A0A2R8ZRI4
uniprot id: A0A2R8ZXB5
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9597:MSX2
gene id: 9597:MSX2
uniprot id: A1YG93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).
messages: Belongs to the Msh homeobox family.
messages: Interacts with MINT, with XRCC6 (Ku70) and XRCC5 (Ku80).
messages: Nucleus

9597:MRPL49
gene id: 9597:MRPL49
uniprot id: A0A2R9BNA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

9597:SLC25A22
gene id: 9597:SLC25A22
uniprot id: A0A2R9CEH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9597:CCDC22
gene id: 9597:CCDC22
uniprot id: A0A2R9BV45
names: Similarity
messages: Belongs to the CCDC22 family.

9597:RAP2C
gene id: 9597:RAP2C
uniprot id: A0A2R9BPU5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9597:LOC100988671
gene id: 9597:LOC100988671
uniprot id: A0A2R8Z7U5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:SEMA4G
gene id: 9597:SEMA4G
uniprot id: A0A2R9C3P0
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100994763
gene id: 9597:LOC100994763
uniprot id: A0A2R9CA05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9597:STPG1
gene id: 9597:STPG1
uniprot id: A0A2R8ZDR7
uniprot id: A0A2R8ZE84
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:FAM168B
gene id: 9597:FAM168B
uniprot id: A0A2R8Z695
names: Similarity
messages: Belongs to the FAM168 family.

9597:TM9SF1
gene id: 9597:TM9SF1
uniprot id: A0A2R9CC98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9597:CCSER2
gene id: 9597:CCSER2
uniprot id: A0A2R9ADT3
uniprot id: A0A2R9AK67
names: Similarity
messages: Belongs to the CCSER family.

9597:STAM
gene id: 9597:STAM
uniprot id: A0A2R8ZKE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9597:LOC100989472
gene id: 9597:LOC100989472
uniprot id: A0A2R9BRA7
names: Similarity
messages: Belongs to the SPAN-X family.

9597:GIMAP4
gene id: 9597:GIMAP4
uniprot id: A0A2R9BSD2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9597:NDUFB11
gene id: 9597:NDUFB11
uniprot id: A0A2R9B427
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:THADA
gene id: 9597:THADA
uniprot id: A0A2R8ZFZ5
names: Function
names: Similarity
messages: Belongs to the THADA family.
messages: Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.

9597:NDUFAF1
gene id: 9597:NDUFAF1
uniprot id: A0A2R9ATC1
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9597:SUB1
gene id: 9597:SUB1
uniprot id: A0A2R8ZIQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9597:NNAT
gene id: 9597:NNAT
uniprot id: A0A2R9C8E9
uniprot id: A0A2R9C8R6
names: Similarity
messages: Belongs to the neuronatin family.

9597:ELOVL4
gene id: 9597:ELOVL4
uniprot id: A0A2R9CF78
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9597:SLC10A7
gene id: 9597:SLC10A7
uniprot id: A0A2R9AI89
uniprot id: A0A2R9AI90
uniprot id: A0A2R9AI94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9597:MTG1
gene id: 9597:MTG1
uniprot id: A0A2R9AGP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Mitochondrion inner membrane
messages: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.

9597:RSAD2
gene id: 9597:RSAD2
uniprot id: A0A2R9BXP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9597:SDHAF1
gene id: 9597:SDHAF1
uniprot id: A0A2R8ZEV3
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

9597:CCT5
gene id: 9597:CCT5
uniprot id: A0A2R9A7U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9597:TCTN3
gene id: 9597:TCTN3
uniprot id: A0A2R9CK10
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9597:KCNAB1
gene id: 9597:KCNAB1
uniprot id: A0A2R9AAC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9597:LOC100988670
gene id: 9597:LOC100988670
uniprot id: A0A2R8ZPT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:TCEANC2
gene id: 9597:TCEANC2
uniprot id: A0A2R9C9F9
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100980782
gene id: 9597:LOC100980782
uniprot id: A0A2R8ZG75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TMC3
gene id: 9597:TMC3
uniprot id: A0A2R9C9L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9597:TK1
gene id: 9597:TK1
uniprot id: A0A2R9ADQ5
names: Similarity
messages: Belongs to the thymidine kinase family.

9597:SENP3
gene id: 9597:SENP3
uniprot id: A0A2R8Z9E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9597:GRK1
gene id: 9597:GRK1
uniprot id: A0A2R8ZIW3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9597:LOC100994646
gene id: 9597:LOC100994646
uniprot id: A0A2R8ZNH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9597:HIGD2A
gene id: 9597:HIGD2A
uniprot id: A0A2R9BQ37
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9597:LOC100996092
gene id: 9597:LOC100996092
uniprot id: A0A2R8Z7S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TUBGCP4
gene id: 9597:TUBGCP4
uniprot id: A0A2R8ZMP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9597:HGS
gene id: 9597:HGS
uniprot id: A0A2R9CA74
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
messages: multivesicular body membrane

9597:CHRNB1
gene id: 9597:CHRNB1
uniprot id: A0A2R9BBR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:ATG13
gene id: 9597:ATG13
uniprot id: A0A2R9CLU2
uniprot id: A0A2R9CLU8
uniprot id: A0A2R9CLV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9597:TMEM182
gene id: 9597:TMEM182
uniprot id: A0A2R9BN66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9597:PARVG
gene id: 9597:PARVG
uniprot id: A0A2R9BC03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: Membrane

9597:OLFM3
gene id: 9597:OLFM3
uniprot id: A0A2R9B6U0
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9597:ACO1
gene id: 9597:ACO1
uniprot id: A0A2R9ATW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Cytoplasm

9597:LIN54
gene id: 9597:LIN54
uniprot id: A0A2R9CED1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9597:LCN8
gene id: 9597:LCN8
uniprot id: A0A2R9BBZ7
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9597:PELP1
gene id: 9597:PELP1
uniprot id: A0A2R9BTR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RIX1/PELP1 family.
messages: Cytoplasm
messages: Nucleus

9597:CORIN
gene id: 9597:CORIN
uniprot id: A0A2R9ATW5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TMEM129
gene id: 9597:TMEM129
uniprot id: A0A2R9ANL5
uniprot id: A0A2R9AP74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9597:AMPD3
gene id: 9597:AMPD3
uniprot id: A0A2R9AEV2
uniprot id: A0A2R9AEV7
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9597:LSM14A
gene id: 9597:LSM14A
uniprot id: A0A2R9CDQ6
uniprot id: A0A2R9CDR2
names: Similarity
messages: Belongs to the LSM14 family.

9597:IPO7
gene id: 9597:IPO7
uniprot id: A0A2R9BTN9
names: Subcellular Location Annotation
messages: Cytoplasm

9597:PAIP2
gene id: 9597:PAIP2
uniprot id: A0A2R9BVP9
names: Similarity
messages: Belongs to the PAIP2 family.

9597:TRIM56
gene id: 9597:TRIM56
uniprot id: A0A2R8Z9M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9597:OTX2
gene id: 9597:OTX2
uniprot id: A0A2R9CE23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9597:IL2RB
gene id: 9597:IL2RB
uniprot id: A0A2R9B5X3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.

9597:TSPAN16
gene id: 9597:TSPAN16
uniprot id: A0A2R9AUJ0
uniprot id: A0A2R9B0E9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:ISY1
gene id: 9597:ISY1
uniprot id: A0A2R9CAA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9597:NDRG2
gene id: 9597:NDRG2
uniprot id: A0A2R9BQT1
uniprot id: A0A2R9BUA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

9597:CASP8
gene id: 9597:CASP8
uniprot id: A0A2R9AE19
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:FAM53C
gene id: 9597:FAM53C
uniprot id: A0A2R9CCJ3
names: Similarity
messages: Belongs to the FAM53 family.

9597:MMP10
gene id: 9597:MMP10
uniprot id: A0A2R8ZHX4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9597:CLCF1
gene id: 9597:CLCF1
uniprot id: A0A2R9BCG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9597:BRK1
gene id: 9597:BRK1
uniprot id: A0A2R8Z8Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRK1 family.
messages: cytoskeleton

9597:FOXB1
gene id: 9597:FOXB1
uniprot id: A0A2R8ZKY7
names: Subcellular Location Annotation
messages: Nucleus

9597:RAD1
gene id: 9597:RAD1
uniprot id: A0A2R8ZZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9597:ARF1
gene id: 9597:ARF1
uniprot id: A0A2R9ABQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9597:ELL2
gene id: 9597:ELL2
uniprot id: A0A2R8ZKG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9597:LOC100972169
gene id: 9597:LOC100972169
uniprot id: A0A2R8ZPV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ALG8
gene id: 9597:ALG8
uniprot id: A0A2R9ABB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:MARK1
gene id: 9597:MARK1
uniprot id: A0A2R9B216
uniprot id: A0A2R9B5W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9597:RAB19
gene id: 9597:RAB19
uniprot id: A0A2R9APQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane

9597:PER3
gene id: 9597:PER3
uniprot id: A0A2R8ZZN1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:GGA1
gene id: 9597:GGA1
uniprot id: A0A2R8ZK51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9597:FGF10
gene id: 9597:FGF10
uniprot id: A0A2R9BWJ8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:INPP1
gene id: 9597:INPP1
uniprot id: A0A2R9BIM1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9597:CLIC2
gene id: 9597:CLIC2
uniprot id: A0A2R9C5B1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9597:IL2RG
gene id: 9597:IL2RG
uniprot id: A0A2R9BYW9
names: Subcellular Location Annotation
messages: Membrane

9597:LOC100978244
gene id: 9597:LOC100978244
uniprot id: A0A2R8ZEJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:HDX
gene id: 9597:HDX
uniprot id: A0A2R9AJW6
names: Subcellular Location Annotation
messages: Nucleus

9597:FLOT1
gene id: 9597:FLOT1
uniprot id: A0A2R9AGW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

9597:LASP1
gene id: 9597:LASP1
uniprot id: A0A2R8Z9S7
uniprot id: A0A2R8ZG60
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

9597:EXOSC5
gene id: 9597:EXOSC5
uniprot id: A0A2R8ZT64
names: Subcellular Location Annotation
messages: Cytoplasm

9597:GLUL
gene id: 9597:GLUL
uniprot id: A0A2R9CBD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Membrane
messages: Microsome
messages: Mitochondrion

9597:CDCA7L
gene id: 9597:CDCA7L
uniprot id: A0A2R9BGC1
uniprot id: A0A2R9BK13
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9597:RBL2
gene id: 9597:RBL2
uniprot id: A0A2R9BEV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9597:VARS1
gene id: 9597:VARS1
uniprot id: A0A2R9AWC1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:ATP5MG
gene id: 9597:ATP5MG
uniprot id: A0A2R8Z8D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9597:LOC100979500
gene id: 9597:LOC100979500
uniprot id: A0A2R8Z9M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:CLDN7
gene id: 9597:CLDN7
uniprot id: A0A2R9B348
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:CRYZ
gene id: 9597:CRYZ
uniprot id: A0A2R9CDZ6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9597:TNFSF13B
gene id: 9597:TNFSF13B
uniprot id: A0A2R8ZNW2
uniprot id: A0A2R8ZQJ1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9597:ZRANB2
gene id: 9597:ZRANB2
uniprot id: A0A2R9BEH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9597:CYP4F22
gene id: 9597:CYP4F22
uniprot id: A0A2R9C8I6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:OPA1
gene id: 9597:OPA1
uniprot id: A0A2R9BC55
uniprot id: A0A2R9BDG8
uniprot id: A0A2R9BFZ6
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9597:LNPK
gene id: 9597:LNPK
uniprot id: A0A2R9ABG0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9597:HOXA9
gene id: 9597:HOXA9
uniprot id: A0A2R9A8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9597:RNF43
gene id: 9597:RNF43
uniprot id: A0A2R9AZ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

9597:ABCB8
gene id: 9597:ABCB8
uniprot id: A0A2R9AS88
names: Subcellular Location Annotation
messages: Membrane

9597:MSH4
gene id: 9597:MSH4
uniprot id: A0A2R9BEZ3
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9597:RNMT
gene id: 9597:RNMT
uniprot id: A0A2R8ZPU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9597:YBEY
gene id: 9597:YBEY
uniprot id: A0A2R9AKQ5
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

9597:RBP1
gene id: 9597:RBP1
uniprot id: A0A2R8ZX83
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:POGLUT2
gene id: 9597:POGLUT2
uniprot id: A0A2R9A598
names: Similarity
messages: Belongs to the KDELC family.

9597:CNOT10
gene id: 9597:CNOT10
uniprot id: A0A2R8ZSB8
uniprot id: A0A2R8ZY54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

9597:CTSZ
gene id: 9597:CTSZ
uniprot id: A0A2R9CIR6
names: Similarity
messages: Belongs to the peptidase C1 family.

9597:DNAAF2
gene id: 9597:DNAAF2
uniprot id: A0A2R9CEY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

9597:LOC100991751
gene id: 9597:LOC100991751
uniprot id: A0A2R9BFK5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9597:CLP1
gene id: 9597:CLP1
uniprot id: A0A2R9C6Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9597:CHRNA2
gene id: 9597:CHRNA2
uniprot id: A0A2R9C9T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:DPH6
gene id: 9597:DPH6
uniprot id: A0A2R8Z9F9
uniprot id: A0A2R8ZG56
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
messages: Belongs to the Diphthine--ammonia ligase family.

9597:APEX1
gene id: 9597:APEX1
uniprot id: A1YFZ3
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-6 and Lys-7. Acetylation is increased by the transcriptional coactivator EP300 acetyltransferase, genotoxic agents like H(2)O(2) and methyl methanesulfonate (MMS). Acetylation increases its binding affinity to the negative calcium response element (nCaRE) DNA promoter. The acetylated form induces a stronger binding of YBX1 to the Y-box sequence in the MDR1 promoter than the unacetylated form. Deacetylated on lysines. Lys-6 and Lys-7 are deacetylated by SIRT1 (By similarity).
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cleaved at Lys-31 by granzyme A to create the mitochondrial form; leading in reduction of binding to DNA, AP endodeoxyribonuclease activity, redox activation of transcription factors and to enhanced cell death. Cleaved by granzyme K; leading to intracellular ROS accumulation and enhanced cell death after oxidative stress (By similarity).
messages: Cys-69 and Cys-93 are nitrosylated in response to nitric oxide (NO) and lead to the exposure of the nuclear export signal (NES).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: Monomer. Homodimer; disulfide-linked. Component of the SET complex, composed of at least APEX1, SET, ANP32A, HMGB2, NME1 and TREX1. Associates with the dimer XRCC5/XRCC6 in a DNA-dependent manner. Interacts with SIRT1; the interaction is increased in the context of genotoxic stress. Interacts with HDAC1, HDAC2 and HDAC3; the interactions are not dependent on the APEX1 acetylation status. Interacts with XRCC1; the interaction is induced by SIRT1 and increased with the APEX1 acetylated form. Interacts with NPM1 (via N-terminal domain); the interaction is RNA-dependent and decreases in hydrogen peroxide-damaged cells. Interacts (via N-terminus) with YBX1 (via C-terminus); the interaction is increased in presence of APEX1 acetylated at Lys-6 and Lys-7. Interacts with HNRNPL; the interaction is DNA-dependent. Interacts (via N-terminus) with KPNA1 and KPNA2. Interacts with TXN; the interaction stimulates the FOS/JUN AP-1 complex DNA-binding activity in a redox-dependent manner. Interacts with GZMA, KRT8, MDM2, POLB, PRDX6, PRPF19, RPLP0, TOMM20 and WDR77. Binds to CDK5 (By similarity).
messages: Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repr…
messages: NPM1 stimulates endodeoxyribonuclease activity on double-stranded DNA with AP sites, but inhibits endoribonuclease activity on single-stranded RNA containing AP sites.
messages: Nucleus
messages: Nucleus speckle
messages: Phosphorylated. Phosphorylation by kinase PKC or casein kinase CK2 results in enhanced redox activity that stimulates binding of the FOS/JUN AP-1 complex to its cognate binding site. AP-endodeoxyribonuclease activity is not affected by CK2-mediated phosphorylation. Phosphorylation of Thr-233 by CDK5 in response to MPP(+)/MPTP (1-methyl-4-phenylpyridinium) reduces AP-endodeoxyribonuclease activity resulting in accumulation of DNA damage and contributing to neuronal death (By similarity).
messages: Probably binds two magnesium or manganese ions per subunit.
messages: The N-terminus contains the redox activity while the C-terminus exerts the DNA AP-endodeoxyribonuclease activity; both function are independent in their actions. An unconventional mitochondrial targeting sequence (MTS) is harbored within the C-terminus, that appears to be masked by the N-terminal sequence containing the nuclear localization signal (NLS), that probably blocks the interaction between the MTS and Tom proteins (By similarity).
messages: The specific activity of the cleaved mitochondrial endodeoxyribonuclease appeared to be about 3-fold higher than of the full-length form. Extract of mitochondria, but not of nuclei or cytosol, cleaves recombinant APEX1 to generate a mitochondrial APEX1-sized product (By similarity).
messages: Ubiquitinated by MDM2; leading to translocation to the cytoplasm and proteasomal degradation.
messages: nucleolus

9597:PLPPR2
gene id: 9597:PLPPR2
uniprot id: A0A2R9AWN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9597:ZNF671
gene id: 9597:ZNF671
uniprot id: A0A2R9CHI0
names: Function
messages: May be involved in transcriptional regulation.

9597:TSPAN5
gene id: 9597:TSPAN5
uniprot id: A0A2R9CKV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:SMUG1
gene id: 9597:SMUG1
uniprot id: A0A2R9AUP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9597:WNT16
gene id: 9597:WNT16
uniprot id: A0A2R8ZZ85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:MAOA
gene id: 9597:MAOA
uniprot id: A0A2R9ARD5
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9597:RNFT2
gene id: 9597:RNFT2
uniprot id: A0A2R9BE12
names: Subcellular Location Annotation
messages: Membrane

9597:RPL7A
gene id: 9597:RPL7A
uniprot id: A0A2R8ZHQ8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

9597:MYADML2
gene id: 9597:MYADML2
uniprot id: A0A2R8Z737
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9597:SBDS
gene id: 9597:SBDS
uniprot id: A0A2R9CL09
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9597:GET3
gene id: 9597:GET3
uniprot id: A0A2R9CEY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

9597:MAP3K8
gene id: 9597:MAP3K8
uniprot id: A0A2R9BD20
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9597:TEKT1
gene id: 9597:TEKT1
uniprot id: A0A2R9ATM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9597:TRIP12
gene id: 9597:TRIP12
uniprot id: A0A2R9CE67
uniprot id: A0A2R9CE74
uniprot id: A0A2R9CPA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

9597:SLC17A7
gene id: 9597:SLC17A7
uniprot id: A0A2R9CBP1
names: Subcellular Location Annotation
messages: Membrane

9597:SLC39A2
gene id: 9597:SLC39A2
uniprot id: A0A2R9ATW1
names: Subcellular Location Annotation
messages: Membrane

9597:BSCL2
gene id: 9597:BSCL2
uniprot id: A0A2R9CF10
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:ZSCAN30
gene id: 9597:ZSCAN30
uniprot id: A0A2R9CB23
names: Subcellular Location Annotation
messages: Nucleus

9597:EDN3
gene id: 9597:EDN3
uniprot id: A0A2R9B636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9597:SLC25A5
gene id: 9597:SLC25A5
uniprot id: A0A2R9BII9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9597:TMIGD2
gene id: 9597:TMIGD2
uniprot id: A0A2R9AS87
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:LOC100972442
gene id: 9597:LOC100972442
uniprot id: A0A2R9A9C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9597:PRICKLE2
gene id: 9597:PRICKLE2
uniprot id: A0A2R9BE32
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9597:PHKA1
gene id: 9597:PHKA1
uniprot id: A0A2R9CAS6
uniprot id: A0A2R9CAX2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9597:PFKFB3
gene id: 9597:PFKFB3
uniprot id: A0A2R8ZUU5
uniprot id: A0A2R8ZVW9
uniprot id: A0A2R8ZY79
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9597:VAMP7
gene id: 9597:VAMP7
uniprot id: A0A2R9ATW9
uniprot id: A0A2R9AW65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9597:TMOD4
gene id: 9597:TMOD4
uniprot id: A0A2R9ANE4
names: Subcellular Location Annotation
messages: cytoskeleton

9597:SLC50A1
gene id: 9597:SLC50A1
uniprot id: A0A2R8ZEU0
uniprot id: A0A2R8ZFB0
uniprot id: A0A2R8ZFB3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

9597:CBX5
gene id: 9597:CBX5
uniprot id: A0A2R9A4K7
names: Subcellular Location Annotation
messages: Nucleus

9597:RIMKLA
gene id: 9597:RIMKLA
uniprot id: A0A2R9AR13
names: Similarity
messages: Belongs to the RimK family.

9597:SMG9
gene id: 9597:SMG9
uniprot id: A0A2R9AAK9
names: Similarity
messages: Belongs to the SMG9 family.

9597:CLTC
gene id: 9597:CLTC
uniprot id: A0A2R9A1V6
uniprot id: A0A2R9A770
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9597:SLC35F2
gene id: 9597:SLC35F2
uniprot id: A0A2R8ZG94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9597:DKC1
gene id: 9597:DKC1
uniprot id: A0A2R8ZSQ5
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9597:NME5
gene id: 9597:NME5
uniprot id: A0A2R9ADE6
names: Similarity
messages: Belongs to the NDK family.

9597:OPA3
gene id: 9597:OPA3
uniprot id: A0A2R9C1S7
uniprot id: A0A2R9C4S4
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

9597:GIMAP7
gene id: 9597:GIMAP7
uniprot id: A0A2R8ZHS2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9597:VANGL1
gene id: 9597:VANGL1
uniprot id: A0A2R9BKR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9597:DRP2
gene id: 9597:DRP2
uniprot id: A0A2R8Z9Q8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system.
messages: dendrite

9597:LOC100980208
gene id: 9597:LOC100980208
uniprot id: A0A2R8ZGR2
names: Similarity
messages: Belongs to the FAM47 family.

9597:PARP4
gene id: 9597:PARP4
uniprot id: A0A2R8ZM55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9597:PDK1
gene id: 9597:PDK1
uniprot id: A0A2R9CDP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9597:PGLS
gene id: 9597:PGLS
uniprot id: A0A2R8ZUQ4
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

9597:KATNB1
gene id: 9597:KATNB1
uniprot id: A0A2R9BH03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9597:ATP5F1E
gene id: 9597:ATP5F1E
uniprot id: A0A2R8ZJS5
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9597:ARF3
gene id: 9597:ARF3
uniprot id: A0A2R9AC12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9597:CPO
gene id: 9597:CPO
uniprot id: A0A2R9AYB1
names: Similarity
messages: Belongs to the peptidase M14 family.

9597:CYLD
gene id: 9597:CYLD
uniprot id: A0A2R9A2C5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9597:JMJD1C
gene id: 9597:JMJD1C
uniprot id: A0A2R9CGF6
names: Subcellular Location Annotation
messages: Nucleus

9597:SPOCK3
gene id: 9597:SPOCK3
uniprot id: A0A2R9AUX5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:MALL
gene id: 9597:MALL
uniprot id: A0A2R8ZNM6
names: Subcellular Location Annotation
messages: Membrane

9597:PRC1
gene id: 9597:PRC1
uniprot id: A0A2R9AVZ8
uniprot id: A0A2R9AW51
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

9597:DYNLT3
gene id: 9597:DYNLT3
uniprot id: A0A2R8ZFW4
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9597:OGG1
gene id: 9597:OGG1
uniprot id: A0A2R9AA36
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

9597:DCPS
gene id: 9597:DCPS
uniprot id: A0A2R9AJD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

9597:STAM2
gene id: 9597:STAM2
uniprot id: A0A2R9BIG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9597:LOC106635239
gene id: 9597:LOC106635239
uniprot id: A0A2R8ZK78
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9597:GRAMD1C
gene id: 9597:GRAMD1C
uniprot id: A0A2R9CQY7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:TPRA1
gene id: 9597:TPRA1
uniprot id: A0A2R8ZU28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9597:ARF5
gene id: 9597:ARF5
uniprot id: A0A2R9BSB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9597:NSFL1C
gene id: 9597:NSFL1C
uniprot id: A0A2R8ZUQ8
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

9597:AIF1
gene id: 9597:AIF1
uniprot id: A0A2R9BT36
names: Subcellular Location Annotation
messages: ruffle membrane

9597:ADGRF1
gene id: 9597:ADGRF1
uniprot id: A0A2R8ZWS3
names: Subcellular Location Annotation
messages: Membrane

9597:GUCY2F
gene id: 9597:GUCY2F
uniprot id: A0A2R9CI03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

9597:STMN1
gene id: 9597:STMN1
uniprot id: A0A2R9BTL6
names: Similarity
messages: Belongs to the stathmin family.

9597:MED12
gene id: 9597:MED12
uniprot id: A0A2R9APR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

9597:TSSC4
gene id: 9597:TSSC4
uniprot id: A0A2R8ZVB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TSSC4 family.
messages: Cytoplasm
messages: Nucleus

9597:ARHGDIA
gene id: 9597:ARHGDIA
uniprot id: A0A2R9BA66
names: Similarity
messages: Belongs to the Rho GDI family.

9597:DIABLO
gene id: 9597:DIABLO
uniprot id: A0A2R8ZB90
names: Subcellular Location Annotation
messages: Mitochondrion

9597:RPS20
gene id: 9597:RPS20
uniprot id: A0A2R8Z8W6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

9597:SSR3
gene id: 9597:SSR3
uniprot id: A0A2R9B068
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9597:PRDX5
gene id: 9597:PRDX5
uniprot id: A0A2R9AGM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Peroxisome matrix
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

9597:LOC100991035
gene id: 9597:LOC100991035
uniprot id: A0A2R8ZHK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

9597:TGM2
gene id: 9597:TGM2
uniprot id: A0A2R9A118
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9597:PPFIA3
gene id: 9597:PPFIA3
uniprot id: A0A2R8ZQ03
uniprot id: A0A2R8ZT21
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9597:CBR1
gene id: 9597:CBR1
uniprot id: A0A2R9ARG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9597:NAB1
gene id: 9597:NAB1
uniprot id: A0A2R8ZD15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9597:THRB
gene id: 9597:THRB
uniprot id: A0A2R9A4E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9597:LOC100983684
gene id: 9597:LOC100983684
uniprot id: A0A2R9BWN2
names: Similarity
messages: Belongs to the SERF family.

9597:MAPKAPK3
gene id: 9597:MAPKAPK3
uniprot id: A0A2R9A884
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:MMD
gene id: 9597:MMD
uniprot id: A0A2R9C4U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9597:SPACA3
gene id: 9597:SPACA3
uniprot id: A0A2R9BWV7
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9597:ITIH6
gene id: 9597:ITIH6
uniprot id: A0A2R9ACS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9597:TREH
gene id: 9597:TREH
uniprot id: A0A2R9C6C2
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

9597:SAP18
gene id: 9597:SAP18
uniprot id: A0A2R9ACB7
names: Similarity
messages: Belongs to the SAP18 family.

9597:SDHAF2
gene id: 9597:SDHAF2
uniprot id: A0A2R9CGW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9597:DDAH2
gene id: 9597:DDAH2
uniprot id: A0A2R8ZJA1
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9597:RETNLB
gene id: 9597:RETNLB
uniprot id: A0A2R9AYS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9597:LITAF
gene id: 9597:LITAF
uniprot id: A0A2R9CI52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9597:LOC100967363
gene id: 9597:LOC100967363
uniprot id: A0A2R8ZEX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:LOC106635329
gene id: 9597:LOC106635329
uniprot id: A0A2R8Z624
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9597:LOC100994750
gene id: 9597:LOC100994750
uniprot id: A0A2R8ZCB5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:TMEM229B
gene id: 9597:TMEM229B
uniprot id: A0A2R9ARX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9597:LIN28A
gene id: 9597:LIN28A
uniprot id: A0A2R9BMX1
names: Similarity
messages: Belongs to the lin-28 family.

9597:ITPRIPL1
gene id: 9597:ITPRIPL1
uniprot id: A0A2R9BRH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9597:DESI1
gene id: 9597:DESI1
uniprot id: A0A2R9B6Y9
names: Similarity
messages: Belongs to the DeSI family.

9597:LIN9
gene id: 9597:LIN9
uniprot id: A0A2R9A8K6
uniprot id: A0A2R9A8M9
names: Similarity
messages: Belongs to the lin-9 family.

9597:C8A
gene id: 9597:C8A
uniprot id: A0A2R9AG52
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9597:PPP2R2C
gene id: 9597:PPP2R2C
uniprot id: A0A2R9BXB7
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9597:CASQ2
gene id: 9597:CASQ2
uniprot id: A0A2R8ZYJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9597:MMP20
gene id: 9597:MMP20
uniprot id: A0A2R8Z9L7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9597:SEH1L
gene id: 9597:SEH1L
uniprot id: A0A2R8ZD69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

9597:KRT16
gene id: 9597:KRT16
uniprot id: A0A2R9BE51
names: Similarity
messages: Belongs to the intermediate filament family.

9597:PVALB
gene id: 9597:PVALB
uniprot id: A0A2R9CGN7
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9597:CA10
gene id: 9597:CA10
uniprot id: A0A2R9A615
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9597:VENTX
gene id: 9597:VENTX
uniprot id: A0A2R9C0P0
names: Subcellular Location Annotation
messages: Nucleus

9597:SLC4A8
gene id: 9597:SLC4A8
uniprot id: A0A2R9AN33
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9597:SNAPC3
gene id: 9597:SNAPC3
uniprot id: A0A2R8ZM08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

9597:MAP4K3
gene id: 9597:MAP4K3
uniprot id: A0A2R9AAI2
uniprot id: A0A2R9AAI7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9597:XPO1
gene id: 9597:XPO1
uniprot id: A0A2R9AC81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9597:KRT20
gene id: 9597:KRT20
uniprot id: A0A2R9AN97
names: Similarity
messages: Belongs to the intermediate filament family.

9597:LOC100970784
gene id: 9597:LOC100970784
uniprot id: A0A2R9BEQ1
names: Function
messages: May be involved in transcriptional regulation.

9597:RAB3GAP1
gene id: 9597:RAB3GAP1
uniprot id: A0A2R9A2X7
uniprot id: A0A2R9A751
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm
messages: Endoplasmic reticulum

9597:SLC47A1
gene id: 9597:SLC47A1
uniprot id: A0A2R9CIM8
uniprot id: A0A2R9CLD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

9597:ZFP69
gene id: 9597:ZFP69
uniprot id: A0A2R9A6H0
names: Function
messages: May be involved in transcriptional regulation.

9597:HSD17B2
gene id: 9597:HSD17B2
uniprot id: A0A2R9BJN5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:TBX4
gene id: 9597:TBX4
uniprot id: A0A2R9BRB8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:SHFL
gene id: 9597:SHFL
uniprot id: A0A2R9BLJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Cytoplasm
messages: Nucleus

9597:DUOXA2
gene id: 9597:DUOXA2
uniprot id: A0A2R9AQS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9597:LOC100973098
gene id: 9597:LOC100973098
uniprot id: A0A2R9CBI8
names: Similarity
messages: Belongs to the TCTP family.

9597:GATA3
gene id: 9597:GATA3
uniprot id: A0A2R8ZRJ9
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC100975643
gene id: 9597:LOC100975643
uniprot id: A0A2R8ZMP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TRAPPC3L
gene id: 9597:TRAPPC3L
uniprot id: A0A2R9CJN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9597:TMEM150B
gene id: 9597:TMEM150B
uniprot id: A0A2R9CAD4
names: Subcellular Location Annotation
messages: Membrane

9597:KRT74
gene id: 9597:KRT74
uniprot id: A0A2R9AVZ5
names: Similarity
messages: Belongs to the intermediate filament family.

9597:ACBD5
gene id: 9597:ACBD5
uniprot id: A0A2R9BMG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

9597:CRISP2
gene id: 9597:CRISP2
uniprot id: A0A075IM97
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:MANEAL
gene id: 9597:MANEAL
uniprot id: A0A2R9AR19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:SUMF1
gene id: 9597:SUMF1
uniprot id: A0A2R9AJ41
uniprot id: A0A2R9ARB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9597:CERT1
gene id: 9597:CERT1
uniprot id: A0A2R9CD16
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

9597:NSMCE2
gene id: 9597:NSMCE2
uniprot id: A0A2R9CF00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

9597:FRRS1
gene id: 9597:FRRS1
uniprot id: A0A2R9C039
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

9597:GYS1
gene id: 9597:GYS1
uniprot id: A0A2R9BUZ0
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9597:PTPRE
gene id: 9597:PTPRE
uniprot id: A0A2R8ZBK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

9597:NSUN3
gene id: 9597:NSUN3
uniprot id: A0A2R9A3P8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9597:YPEL2
gene id: 9597:YPEL2
uniprot id: A0A2R9ASV6
names: Similarity
messages: Belongs to the yippee family.

9597:RPAP1
gene id: 9597:RPAP1
uniprot id: A0A2R9B7W3
uniprot id: A0A2R9BA33
names: Similarity
messages: Belongs to the RPAP1 family.

9597:OAZ2
gene id: 9597:OAZ2
uniprot id: A0A2R9B1C3
names: Similarity
messages: Belongs to the ODC antizyme family.

9597:ITGA7
gene id: 9597:ITGA7
uniprot id: A0A2R9B992
uniprot id: A0A2R9B996
uniprot id: A0A2R9BAN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:FAM47E
gene id: 9597:FAM47E
uniprot id: A0A2R9C295
names: Similarity
messages: Belongs to the FAM47 family.

9597:MANEA
gene id: 9597:MANEA
uniprot id: A0A2R9CIF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:RELL2
gene id: 9597:RELL2
uniprot id: A0A2R8ZJI3
names: Similarity
messages: Belongs to the RELT family.

9597:NDC1
gene id: 9597:NDC1
uniprot id: A0A2R9ARW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

9597:DRC1
gene id: 9597:DRC1
uniprot id: A0A2R9A9Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC1 family.
messages: cilium axoneme
messages: flagellum axoneme

9597:PLAUR
gene id: 9597:PLAUR
uniprot id: A0A2R9CLY4
uniprot id: A0A2R9CNW1
uniprot id: A0A2R9CTD1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:MYO3A
gene id: 9597:MYO3A
uniprot id: A0A2R9CG26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

9597:LOC100993752
gene id: 9597:LOC100993752
uniprot id: A0A2R8ZIC3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:FDXR
gene id: 9597:FDXR
uniprot id: A0A2R9BBF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion

9597:SLC26A6
gene id: 9597:SLC26A6
uniprot id: A0A2R8ZWF2
uniprot id: A0A2R8ZXL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9597:PTGR1
gene id: 9597:PTGR1
uniprot id: A0A2R8ZGR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9597:TOMM20
gene id: 9597:TOMM20
uniprot id: A0A2R9ABS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:ZGPAT
gene id: 9597:ZGPAT
uniprot id: A0A2R8ZW92
uniprot id: A0A2R8ZXD4
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CHD4/Mi-2; the interaction is direct.
messages: Nucleus

9597:RIPK2
gene id: 9597:RIPK2
uniprot id: A0A2R9CNU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments.

9597:RAMP2
gene id: 9597:RAMP2
uniprot id: A0A2R9BNU3
names: Similarity
messages: Belongs to the RAMP family.

9597:ATIC
gene id: 9597:ATIC
uniprot id: A0A2R9AHH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PurH family.
messages: cytosol

9597:ADI1
gene id: 9597:ADI1
uniprot id: A0A2R9AS51
uniprot id: A0A2R9AYN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

9597:B4GALT6
gene id: 9597:B4GALT6
uniprot id: A0A2R9B980
uniprot id: A0A2R9BGQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9597:MAML2
gene id: 9597:MAML2
uniprot id: A0A2R9AVW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

9597:LOC100971133
gene id: 9597:LOC100971133
uniprot id: A0A2R8ZP77
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:ETS2
gene id: 9597:ETS2
uniprot id: A0A2R9A0Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcription factor.

9597:TXNL4A
gene id: 9597:TXNL4A
uniprot id: A0A2R9B0Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9597:DAO
gene id: 9597:DAO
uniprot id: A0A2R9AD44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9597:LOC100992458
gene id: 9597:LOC100992458
uniprot id: A0A2R8ZMQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:PPP1R1B
gene id: 9597:PPP1R1B
uniprot id: A0A2R9A0A7
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9597:PICALM
gene id: 9597:PICALM
uniprot id: A0A2R9B9L3
uniprot id: A0A2R9BH69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9597:LOC100969871
gene id: 9597:LOC100969871
uniprot id: A0A2R8Z664
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:NR4A1
gene id: 9597:NR4A1
uniprot id: A0A2R9B4U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7.
messages: Nucleus
messages: cytosol

9597:DCAF10
gene id: 9597:DCAF10
uniprot id: A0A2R9CCE8
names: Function
names: Similarity
messages: Belongs to the WD repeat DCAF10 family.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9597:MOB4
gene id: 9597:MOB4
uniprot id: A0A2R8ZSS0
uniprot id: A0A2R9CLU1
uniprot id: A0A2R9CLY0
names: Similarity
messages: Belongs to the GroES chaperonin family.
messages: Belongs to the MOB1/phocein family.

9597:ARV1
gene id: 9597:ARV1
uniprot id: A0A2R9CIA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9597:NOG
gene id: 9597:NOG
uniprot id: A0A2R8ZAH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9597:SEC23B
gene id: 9597:SEC23B
uniprot id: A0A2R8ZQH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9597:LDHB
gene id: 9597:LDHB
uniprot id: A0A2R9AUG7
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9597:C1D
gene id: 9597:C1D
uniprot id: A0A2R9BSU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9597:NTNG2
gene id: 9597:NTNG2
uniprot id: A0A2R9B8T1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:GIMAP1
gene id: 9597:GIMAP1
uniprot id: A0A2R9C9Q1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9597:CCL25
gene id: 9597:CCL25
uniprot id: A0A2R9AG69
names: Subcellular Location Annotation
messages: Secreted

9597:COQ4
gene id: 9597:COQ4
uniprot id: A0A2R9BE98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

9597:KIF9
gene id: 9597:KIF9
uniprot id: A0A2R9C3D6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:MBOAT1
gene id: 9597:MBOAT1
uniprot id: A0A2R9A5F8
names: Subcellular Location Annotation
messages: Membrane

9597:TGS1
gene id: 9597:TGS1
uniprot id: A0A2R9BRR3
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9597:HAX1
gene id: 9597:HAX1
uniprot id: A0A2R9A4K5
names: Function
names: Similarity
messages: Belongs to the HAX1 family.
messages: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

9597:CPLX2
gene id: 9597:CPLX2
uniprot id: A0A2R9BKE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9597:NPRL2
gene id: 9597:NPRL2
uniprot id: A0A2R8ZGV7
names: Similarity
messages: Belongs to the NPR2 family.

9597:ZSCAN29
gene id: 9597:ZSCAN29
uniprot id: A0A2R8ZCT9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:PARN
gene id: 9597:PARN
uniprot id: A0A2R9APG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm

9597:LOC100980041
gene id: 9597:LOC100980041
uniprot id: A0A2R8ZQ92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TANGO6
gene id: 9597:TANGO6
uniprot id: A0A2R9C531
names: Similarity
messages: Belongs to the Tango6 family.

9597:MRPL47
gene id: 9597:MRPL47
uniprot id: A0A2R8ZX91
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9597:PHOSPHO2
gene id: 9597:PHOSPHO2
uniprot id: A0A2R8ZP24
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9597:SPATA20
gene id: 9597:SPATA20
uniprot id: A0A2R9AID4
uniprot id: A0A2R9AIE2
uniprot id: A0A2R9AIE4
names: Function
names: Subcellular Location Annotation
messages: May play a role in fertility regulation.
messages: Secreted

9597:SLX1A
gene id: 9597:SLX1A
uniprot id: A0A2R8ZB37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
messages: Forms a heterodimer with SLX4.
messages: Nucleus

9597:GABRA3
gene id: 9597:GABRA3
uniprot id: A0A2R9AHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:LOC100979846
gene id: 9597:LOC100979846
uniprot id: A0A2R8ZKC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:RAB33A
gene id: 9597:RAB33A
uniprot id: A0A2R9BLL4
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9597:CLPX
gene id: 9597:CLPX
uniprot id: A0A2R9C105
names: Similarity
messages: Belongs to the ClpX chaperone family.

9597:CNOT9
gene id: 9597:CNOT9
uniprot id: A0A2R9BF52
uniprot id: A0A2R9BF69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9597:BRF1
gene id: 9597:BRF1
uniprot id: A0A2R9ARC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIB family.
messages: Nucleus

9597:CENPN
gene id: 9597:CENPN
uniprot id: A0A2R9B8F1
uniprot id: A0A2R9B8F7
uniprot id: A0A2R9B9W8
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9597:C5H5orf63
gene id: 9597:C5H5orf63
uniprot id: A0A2R9CNA0
names: Similarity
messages: Belongs to the glutaredoxin family.

9597:ZNF711
gene id: 9597:ZNF711
uniprot id: A0A2R9BKX2
uniprot id: A0A2R9BPG3
names: Subcellular Location Annotation
messages: Nucleus

9597:DPM1
gene id: 9597:DPM1
uniprot id: A0A2R9CPW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9597:RELT
gene id: 9597:RELT
uniprot id: A0A2R9AKJ8
names: Similarity
messages: Belongs to the RELT family.

9597:FAM161A
gene id: 9597:FAM161A
uniprot id: A0A2R9BGS1
uniprot id: A0A2R9BGS6
names: Similarity
messages: Belongs to the FAM161 family.

9597:ISL1
gene id: 9597:ISL1
uniprot id: A0A2R9B1B8
names: Subcellular Location Annotation
messages: Nucleus

9597:FAM135A
gene id: 9597:FAM135A
uniprot id: A0A2R9AYL5
uniprot id: A0A2R9B1Y3
uniprot id: A0A2R9B1Z4
names: Similarity
messages: Belongs to the FAM135 family.

9597:ADH1C
gene id: 9597:ADH1C
uniprot id: A0A2R9BG61
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9597:ARL2
gene id: 9597:ARL2
uniprot id: A0A2R9C7Z2
uniprot id: A0A2R9CI81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9597:HGD
gene id: 9597:HGD
uniprot id: A0A2R9AGX4
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9597:CSGALNACT1
gene id: 9597:CSGALNACT1
uniprot id: A0A2R8ZH43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9597:LRP6
gene id: 9597:LRP6
uniprot id: A0A2R9B648
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:ADAMTS1
gene id: 9597:ADAMTS1
uniprot id: A0A2R8Z755
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9597:NCOA3
gene id: 9597:NCOA3
uniprot id: A0A2R9AXC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9597:FPR3
gene id: 9597:FPR3
uniprot id: A0A2R8Z8J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9597:KCNK2
gene id: 9597:KCNK2
uniprot id: A0A2R9ACZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9597:PPARGC1A
gene id: 9597:PPARGC1A
uniprot id: A0A2R9B1U3
names: Subcellular Location Annotation
messages: PML body

9597:ZNF180
gene id: 9597:ZNF180
uniprot id: A0A2R9A1Z5
names: Function
messages: May be involved in transcriptional regulation.

9597:HOXB2
gene id: 9597:HOXB2
uniprot id: A0A2R8ZZG6
names: Subcellular Location Annotation
messages: Nucleus

9597:NFS1
gene id: 9597:NFS1
uniprot id: A0A2R9BYF7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9597:MMACHC
gene id: 9597:MMACHC
uniprot id: A0A2R9CDN8
names: Similarity
messages: Belongs to the MMACHC family.

9597:ZNF461
gene id: 9597:ZNF461
uniprot id: A0A2R9CCK5
uniprot id: A0A2R9CF77
names: Function
messages: May be involved in transcriptional regulation.

9597:GUCA2A
gene id: 9597:GUCA2A
uniprot id: A0A2R9AA40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9597:ACTR1A
gene id: 9597:ACTR1A
uniprot id: A0A2R9AD10
names: Similarity
messages: Belongs to the actin family.

9597:SLC6A17
gene id: 9597:SLC6A17
uniprot id: A0A2R9CBH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9597:KAT8
gene id: 9597:KAT8
uniprot id: A0A2R8ZFG4
uniprot id: A0A2R8ZLX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9597:ERCC1
gene id: 9597:ERCC1
uniprot id: A0A2R9CJ12
uniprot id: A0A2R9CJ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

9597:TMEM116
gene id: 9597:TMEM116
uniprot id: A0A2R9B7C8
names: Subcellular Location Annotation
messages: Membrane

9597:RAD50
gene id: 9597:RAD50
uniprot id: A0A2R9ACX5
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9597:AFF2
gene id: 9597:AFF2
uniprot id: A0A2R9BYY5
names: Similarity
messages: Belongs to the AF4 family.

9597:PEX5L
gene id: 9597:PEX5L
uniprot id: A0A2R9BA15
uniprot id: A0A2R9BB44
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9597:TMPO
gene id: 9597:TMPO
uniprot id: A0A2R9AK93
names: Similarity
messages: Belongs to the LEM family.

9597:PIGH
gene id: 9597:PIGH
uniprot id: A0A2R9C3M8
names: Similarity
messages: Belongs to the PIGH family.

9597:PDE8B
gene id: 9597:PDE8B
uniprot id: A0A2R9BFR9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:CNRIP1
gene id: 9597:CNRIP1
uniprot id: A0A2R9B9K6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9597:SLC25A25
gene id: 9597:SLC25A25
uniprot id: A0A2R8ZP57
uniprot id: A0A2R8ZP71
uniprot id: A0A2R8ZQE2
uniprot id: A0A2R8ZS84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:CDPF1
gene id: 9597:CDPF1
uniprot id: A0A2R9CEQ5
names: Similarity
messages: Belongs to the CDPF1 family.

9597:MTMR6
gene id: 9597:MTMR6
uniprot id: A0A2R9B6J7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9597:AGTPBP1
gene id: 9597:AGTPBP1
uniprot id: A0A2R9CLG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9597:SYCE1L
gene id: 9597:SYCE1L
uniprot id: A0A2R9C0V3
names: Similarity
messages: Belongs to the SYCE family.

9597:HSPA5
gene id: 9597:HSPA5
uniprot id: A0A2R9CFE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cell surface
messages: Endoplasmic reticulum lumen
messages: Melanosome

9597:DEFB110
gene id: 9597:DEFB110
uniprot id: A0A2R9CCY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9597:ACOT8
gene id: 9597:ACOT8
uniprot id: A0A2R9B004
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9597:ZNF445
gene id: 9597:ZNF445
uniprot id: A0A2R9BHM2
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:HNRNPR
gene id: 9597:HNRNPR
uniprot id: A0A2R9CCI5
names: Subcellular Location Annotation
messages: Cytoplasm

9597:DUOX1
gene id: 9597:DUOX1
uniprot id: A0A2R9CDG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane

9597:PDE4B
gene id: 9597:PDE4B
uniprot id: A0A2R9ASE9
uniprot id: A0A2R9AWP0
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:NES
gene id: 9597:NES
uniprot id: A0A2R9B9M3
names: Similarity
messages: Belongs to the intermediate filament family.

9597:MAPRE2
gene id: 9597:MAPRE2
uniprot id: A0A2R9CDJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9597:ADIPOR1
gene id: 9597:ADIPOR1
uniprot id: A0A2R9C7R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9597:TNFSF10
gene id: 9597:TNFSF10
uniprot id: A0A2R9C2U3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9597:SCRN2
gene id: 9597:SCRN2
uniprot id: A0A2R8ZYA1
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9597:MOG
gene id: 9597:MOG
uniprot id: A0A2R8ZJZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9597:ITM2A
gene id: 9597:ITM2A
uniprot id: A0A2R9AP45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9597:LOC100976808
gene id: 9597:LOC100976808
uniprot id: A0A2R8ZDD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCO1/2 family.
messages: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
messages: Homodimer.
messages: Mitochondrion inner membrane

9597:INTS8
gene id: 9597:INTS8
uniprot id: A0A2R9ARS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

9597:ATP6V0A2
gene id: 9597:ATP6V0A2
uniprot id: A0A2R9BD05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9597:RABAC1
gene id: 9597:RABAC1
uniprot id: A0A2R9BKB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9597:APOLD1
gene id: 9597:APOLD1
uniprot id: A0A2R8ZFP6
uniprot id: A0A2R8ZM40
names: Similarity
messages: Belongs to the apolipoprotein L family.

9597:CNOT3
gene id: 9597:CNOT3
uniprot id: A0A2R8Z7Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
messages: Nucleus
messages: P-body

9597:SMIM14
gene id: 9597:SMIM14
uniprot id: A0A2R9CID6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9597:GRID2
gene id: 9597:GRID2
uniprot id: A0A2R9A3M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9597:EIF2B4
gene id: 9597:EIF2B4
uniprot id: A0A2R8ZRJ0
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9597:REXO2
gene id: 9597:REXO2
uniprot id: A0A2R9BWC5
names: Similarity
messages: Belongs to the oligoribonuclease family.

9597:ATL3
gene id: 9597:ATL3
uniprot id: A0A2R8Z5Z9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9597:MMP14
gene id: 9597:MMP14
uniprot id: A0A2R9BFH7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Cytoplasm
messages: Melanosome

9597:MYADM
gene id: 9597:MYADM
uniprot id: A0A2R8Z748
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9597:EPC2
gene id: 9597:EPC2
uniprot id: A0A2R9BXZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9597:NRXN3
gene id: 9597:NRXN3
uniprot id: A0A2R9ALZ5
uniprot id: A0A2R9ARK2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Presynaptic cell membrane

9597:SMIM12
gene id: 9597:SMIM12
uniprot id: A0A2R8Z930
uniprot id: A0A2R8ZA15
names: Similarity
messages: Belongs to the SMIM12 family.

9597:SLC39A14
gene id: 9597:SLC39A14
uniprot id: A0A2R8ZDH0
names: Subcellular Location Annotation
messages: Membrane

9597:CEP44
gene id: 9597:CEP44
uniprot id: A0A2R9AH85
uniprot id: A0A2R9AI66
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

9597:POLA1
gene id: 9597:POLA1
uniprot id: A0A2R9CFV7
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

9597:HS3ST1
gene id: 9597:HS3ST1
uniprot id: A0A2R8ZDV3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:ALPL
gene id: 9597:ALPL
uniprot id: A0A2R9ABM8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9597:NPPC
gene id: 9597:NPPC
uniprot id: A0A2R8ZVM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9597:PDE4D
gene id: 9597:PDE4D
uniprot id: A0A2R9CIU9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:RTN2
gene id: 9597:RTN2
uniprot id: A0A2R9BM18
uniprot id: A0A2R9BM21
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:FMO1
gene id: 9597:FMO1
uniprot id: A0A2R9CCZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:MOK
gene id: 9597:MOK
uniprot id: A0A2R9A571
uniprot id: A0A2R9A576
uniprot id: A0A2R9A9X7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9597:ATP5MC2
gene id: 9597:ATP5MC2
uniprot id: A0A2R9BIL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9597:GRIA3
gene id: 9597:GRIA3
uniprot id: A0A2R8ZQ00
uniprot id: A0A2R8ZQ21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9597:TEK
gene id: 9597:TEK
uniprot id: A0A2R9AYN0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:POLD2
gene id: 9597:POLD2
uniprot id: A0A2R9A8G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

9597:GFRAL
gene id: 9597:GFRAL
uniprot id: A0A2R9BKW6
names: Similarity
messages: Belongs to the GDNFR family.

9597:DHH
gene id: 9597:DHH
uniprot id: A0A2R8ZGI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9597:STX11
gene id: 9597:STX11
uniprot id: A0A2R8ZCY5
names: Similarity
messages: Belongs to the syntaxin family.

9597:FAM149B1
gene id: 9597:FAM149B1
uniprot id: A0A2R9BYZ0
names: Similarity
messages: Belongs to the FAM149 family.

9597:HCRT
gene id: 9597:HCRT
uniprot id: A0A2R9A8A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Endoplasmic reticulum
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Synapse
messages: Vesicle

9597:SMIM7
gene id: 9597:SMIM7
uniprot id: A0A2R9BHA4
names: Similarity
messages: Belongs to the SMIM7 family.

9597:SLC35E2B
gene id: 9597:SLC35E2B
uniprot id: A0A2R9BWQ5
names: Subcellular Location Annotation
messages: Membrane

9597:MB
gene id: 9597:MB
uniprot id: A0A2R9BL13
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9597:C8H8orf33
gene id: 9597:C8H8orf33
uniprot id: A0A2R8ZSY3
names: Similarity
messages: Belongs to the UPF0488 family.

9597:MACO1
gene id: 9597:MACO1
uniprot id: A0A2R9CDE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the macoilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane
messages: Plays a role in the regulation of neuronal activity.
messages: Rough endoplasmic reticulum membrane

9597:BORA
gene id: 9597:BORA
uniprot id: A0A2R9B5B9
names: Similarity
messages: Belongs to the BORA family.

9597:CD36
gene id: 9597:CD36
uniprot id: A0A2R8Z8H3
names: Similarity
messages: Belongs to the CD36 family.

9597:GABARAPL1
gene id: 9597:GABARAPL1
uniprot id: A0A2R9B8R1
names: Similarity
messages: Belongs to the ATG8 family.

9597:CHST9
gene id: 9597:CHST9
uniprot id: A0A2R9AA59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:LDAF1
gene id: 9597:LDAF1
uniprot id: A0A2R9BD43
uniprot id: A0A2R9BD48
uniprot id: A0A2R9BLM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9597:CCNJ
gene id: 9597:CCNJ
uniprot id: A0A2R9BUV5
names: Similarity
messages: Belongs to the cyclin family.

9597:GRB10
gene id: 9597:GRB10
uniprot id: A0A2R8ZJ58
uniprot id: A0A2R8ZPN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9597:CMTR1
gene id: 9597:CMTR1
uniprot id: A0A2R9B885
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

9597:ZDHHC12
gene id: 9597:ZDHHC12
uniprot id: A0A2R9BRK9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:PAQR3
gene id: 9597:PAQR3
uniprot id: A0A2R9C4Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9597:MMP1
gene id: 9597:MMP1
uniprot id: A0A2R9C2G5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9597:NKAPL
gene id: 9597:NKAPL
uniprot id: A0A2R8ZU93
names: Similarity
messages: Belongs to the NKAP family.

9597:AQP10
gene id: 9597:AQP10
uniprot id: A0A2R9B3S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9597:CPLX4
gene id: 9597:CPLX4
uniprot id: A0A2R9A7Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9597:PRPF18
gene id: 9597:PRPF18
uniprot id: A0A2R9CC00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

9597:LOC100994559
gene id: 9597:LOC100994559
uniprot id: A0A2R9AES3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9597:VEPH1
gene id: 9597:VEPH1
uniprot id: A0A2R9B0V6
names: Similarity
messages: Belongs to the MELT/VEPH family.

9597:LOC100972219
gene id: 9597:LOC100972219
uniprot id: A0A2R9B2U7
names: Similarity
messages: Belongs to the NipSnap family.

9597:NAP1L3
gene id: 9597:NAP1L3
uniprot id: A0A2R8ZPP2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9597:ATOSA
gene id: 9597:ATOSA
uniprot id: A0A2R9BIL9
uniprot id: A0A2R9BIM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

9597:ARHGEF9
gene id: 9597:ARHGEF9
uniprot id: A0A2R8ZMA8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
messages: Cytoplasm
messages: Interacts with GPHN.
messages: Postsynaptic density

9597:GOT2
gene id: 9597:GOT2
uniprot id: A0A2R9CP09
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9597:TMEM106C
gene id: 9597:TMEM106C
uniprot id: A0A2R9ABZ6
names: Similarity
messages: Belongs to the TMEM106 family.

9597:UCP1
gene id: 9597:UCP1
uniprot id: A0A2R9A0R9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

9597:CLUAP1
gene id: 9597:CLUAP1
uniprot id: A0A2R8ZXU7
uniprot id: A0A2R9A1M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9597:IL36RN
gene id: 9597:IL36RN
uniprot id: A0A2R9C432
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9597:FABP3
gene id: 9597:FABP3
uniprot id: A0A2R9A8D8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:ABCD2
gene id: 9597:ABCD2
uniprot id: A0A2R9ADA4
names: Subcellular Location Annotation
messages: Membrane

9597:RAB3GAP2
gene id: 9597:RAB3GAP2
uniprot id: A0A2R9C7L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

9597:SGK1
gene id: 9597:SGK1
uniprot id: A0A2R9CBV4
uniprot id: A0A2R9CBV5
uniprot id: A0A2R9CC20
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9597:RTCB
gene id: 9597:RTCB
uniprot id: A0A2R9A6G0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9597:APIP
gene id: 9597:APIP
uniprot id: A0A2R9B3W4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9597:ESD
gene id: 9597:ESD
uniprot id: A0A2R9ACC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9597:ZNF688
gene id: 9597:ZNF688
uniprot id: A0A2R9B8U9
names: Function
messages: May be involved in transcriptional regulation.

9597:NEFL
gene id: 9597:NEFL
uniprot id: A0A2R9BTF6
names: Similarity
messages: Belongs to the intermediate filament family.

9597:BTD
gene id: 9597:BTD
uniprot id: A0A2R9B734
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9597:SERINC1
gene id: 9597:SERINC1
uniprot id: A0A2R9C3I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9597:STAMBP
gene id: 9597:STAMBP
uniprot id: A0A2R8ZEM7
names: Similarity
messages: Belongs to the peptidase M67C family.

9597:YTHDC1
gene id: 9597:YTHDC1
uniprot id: A0A2R9C5J6
uniprot id: A0A2R9CG49
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9597:PLLP
gene id: 9597:PLLP
uniprot id: A0A2R9A4G7
names: Subcellular Location Annotation
messages: Membrane

9597:ZFYVE28
gene id: 9597:ZFYVE28
uniprot id: A0A2R8ZE26
names: Similarity
messages: Belongs to the lst-2 family.

9597:LOC100995886
gene id: 9597:LOC100995886
uniprot id: A0A2R8Z9P2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Membrane
messages: Mitochondrion inner membrane

9597:RAD51D
gene id: 9597:RAD51D
uniprot id: A0A2R8ZQR0
uniprot id: A0A2R8ZQR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

9597:BAMBI
gene id: 9597:BAMBI
uniprot id: A0A2R8Z892
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9597:EGR3
gene id: 9597:EGR3
uniprot id: A0A2R9A862
uniprot id: A0A2R9A866
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9597:FAM24A
gene id: 9597:FAM24A
uniprot id: A0A2R9A5R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM24 family.
messages: Secreted

9597:SNAP47
gene id: 9597:SNAP47
uniprot id: A0A2R9A994
names: Similarity
messages: Belongs to the SVAP1 family.

9597:CCKBR
gene id: 9597:CCKBR
uniprot id: A0A2R8ZFK2
uniprot id: A0A2R8ZLJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9597:TAF6
gene id: 9597:TAF6
uniprot id: A0A2R9BD84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9597:AK2
gene id: 9597:AK2
uniprot id: A0A2R9BRP4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9597:RHBDD2
gene id: 9597:RHBDD2
uniprot id: A0A2R9BC47
names: Subcellular Location Annotation
messages: Membrane

9597:TUBGCP5
gene id: 9597:TUBGCP5
uniprot id: A0A2R9A1W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9597:AKAP5
gene id: 9597:AKAP5
uniprot id: A0A2R8ZNQ9
names: Subcellular Location Annotation
messages: Membrane

9597:FMNL3
gene id: 9597:FMNL3
uniprot id: A0A2R9A721
uniprot id: A0A2R9ABS3
names: Similarity
messages: Belongs to the formin homology family.

9597:RBM3
gene id: 9597:RBM3
uniprot id: A0A2R9AXF1
names: Subcellular Location Annotation
messages: Cytoplasm

9597:TLR5
gene id: 9597:TLR5
uniprot id: B3Y635
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9597:LOC100991754
gene id: 9597:LOC100991754
uniprot id: A0A2R8Z5N0
names: Similarity
messages: Belongs to the HPF1 family.

9597:TNFRSF10D
gene id: 9597:TNFRSF10D
uniprot id: A0A2R9B2D6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CCT8
gene id: 9597:CCT8
uniprot id: A0A2R8ZV23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

9597:SMAD5
gene id: 9597:SMAD5
uniprot id: A0A2R9BFQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9597:TBXAS1
gene id: 9597:TBXAS1
uniprot id: A0A2R9A342
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:SLITRK6
gene id: 9597:SLITRK6
uniprot id: A0A2R8ZGU8
names: Similarity
messages: Belongs to the SLITRK family.

9597:VPS72
gene id: 9597:VPS72
uniprot id: A0A2R9BHJ9
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9597:GPATCH11
gene id: 9597:GPATCH11
uniprot id: A0A2R9CR65
names: Similarity
messages: Belongs to the GPATCH11 family.

9597:KRT18
gene id: 9597:KRT18
uniprot id: A0A2R9CIV2
names: Similarity
messages: Belongs to the intermediate filament family.

9597:FGF6
gene id: 9597:FGF6
uniprot id: A0A2R9C1N8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9597:SUPT16H
gene id: 9597:SUPT16H
uniprot id: A0A2R8ZBD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9597:CYSLTR1
gene id: 9597:CYSLTR1
uniprot id: A0A2R8ZA68
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:MRPS14
gene id: 9597:MRPS14
uniprot id: A0A2R9ABE5
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

9597:NOX1
gene id: 9597:NOX1
uniprot id: A0A2R8ZK08
uniprot id: A0A2R8ZL32
uniprot id: A0A2R8ZMV9
names: Subcellular Location Annotation
messages: Membrane

9597:ENSA
gene id: 9597:ENSA
uniprot id: A0A2R8Z6T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9597:CKM
gene id: 9597:CKM
uniprot id: A0A2R9BMI4
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9597:CLCC1
gene id: 9597:CLCC1
uniprot id: A0A2R9B0F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane

9597:HOXD12
gene id: 9597:HOXD12
uniprot id: A0A2R8ZJK8
names: Subcellular Location Annotation
messages: Nucleus

9597:CPM
gene id: 9597:CPM
uniprot id: A0A2R8Z7S1
names: Similarity
messages: Belongs to the peptidase M14 family.

9597:NHERF2
gene id: 9597:NHERF2
uniprot id: A0A2R9ACP3
names: Subcellular Location Annotation
messages: Cell membrane

9597:STOML3
gene id: 9597:STOML3
uniprot id: A0A2R9BA49
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9597:RDH11
gene id: 9597:RDH11
uniprot id: A0A2R9BIG4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:FKTN
gene id: 9597:FKTN
uniprot id: A0A2R8ZUZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9597:SCGB1A1
gene id: 9597:SCGB1A1
uniprot id: A0A2R9BEN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9597:EYA1
gene id: 9597:EYA1
uniprot id: A0A2R8ZJ88
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9597:CCNJL
gene id: 9597:CCNJL
uniprot id: A0A2R9BYM4
names: Similarity
messages: Belongs to the cyclin family.

9597:NCAPD2
gene id: 9597:NCAPD2
uniprot id: A0A2R9CAQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

9597:LIPH
gene id: 9597:LIPH
uniprot id: A0A2R9BPF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9597:TBX6
gene id: 9597:TBX6
uniprot id: A0A2R9A6D9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9597:SLC25A12
gene id: 9597:SLC25A12
uniprot id: A0A2R8ZPJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9597:IFITM2
gene id: 9597:IFITM2
uniprot id: A0A2R9BNR3
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9597:HSPB3
gene id: 9597:HSPB3
uniprot id: A0A2R8ZI34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9597:NME7
gene id: 9597:NME7
uniprot id: A0A2R9BXY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9597:TNFRSF1B
gene id: 9597:TNFRSF1B
uniprot id: A0A2R9AZK3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100977566
gene id: 9597:LOC100977566
uniprot id: A0A2R9CF58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

9597:SH3BGR
gene id: 9597:SH3BGR
uniprot id: A0A2R9BED8
names: Similarity
messages: Belongs to the SH3BGR family.

9597:PLTP
gene id: 9597:PLTP
uniprot id: A0A2R9BXI2
uniprot id: A0A2R9BY69
uniprot id: A0A2R9C0W4
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

9597:NUDT2
gene id: 9597:NUDT2
uniprot id: A0A2R9BKH4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9597:PORCN
gene id: 9597:PORCN
uniprot id: A0A2R9AQ84
uniprot id: A0A2R9AQT1
names: Subcellular Location Annotation
messages: Membrane

9597:NAALAD2
gene id: 9597:NAALAD2
uniprot id: A0A2R9C9A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9597:BCO1
gene id: 9597:BCO1
uniprot id: A0A2R8ZE23
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

9597:RCAN3
gene id: 9597:RCAN3
uniprot id: A0A2R9AD09
names: Similarity
messages: Belongs to the RCAN family.

9597:FN3KRP
gene id: 9597:FN3KRP
uniprot id: A0A2R9B1Z0
names: Similarity
messages: Belongs to the fructosamine kinase family.

9597:PRKAB2
gene id: 9597:PRKAB2
uniprot id: A0A2R9BAT5
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9597:ARPP19
gene id: 9597:ARPP19
uniprot id: A0A2R9B6P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9597:CDK2AP2
gene id: 9597:CDK2AP2
uniprot id: A0A2R9CG83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9597:NHP2
gene id: 9597:NHP2
uniprot id: A0A2R9A0Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9597:P4HA2
gene id: 9597:P4HA2
uniprot id: A0A2R9A1T5
uniprot id: A0A2R9A6B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9597:LAPTM5
gene id: 9597:LAPTM5
uniprot id: A0A2R9ADL0
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9597:FN3K
gene id: 9597:FN3K
uniprot id: A0A2R9CI92
names: Similarity
messages: Belongs to the fructosamine kinase family.

9597:SNX18
gene id: 9597:SNX18
uniprot id: A0A2R9AWI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9597:BROX
gene id: 9597:BROX
uniprot id: A0A2R9BSZ2
names: Similarity
messages: Belongs to the BROX family.

9597:LDHAL6B
gene id: 9597:LDHAL6B
uniprot id: A0A2R8ZGL5
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9597:MANF
gene id: 9597:MANF
uniprot id: A0A2R8ZKA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9597:SUV39H2
gene id: 9597:SUV39H2
uniprot id: A0A2R9AED6
uniprot id: A0A2R9AKX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9597:ITGA2
gene id: 9597:ITGA2
uniprot id: A0A2R9CTC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:PDLIM3
gene id: 9597:PDLIM3
uniprot id: A0A2R9AZT1
names: Subcellular Location Annotation
messages: Z line

9597:ADISSP
gene id: 9597:ADISSP
uniprot id: A0A2R9B4I8
names: Similarity
messages: Belongs to the ADISSP family.

9597:GPR35
gene id: 9597:GPR35
uniprot id: A0A2R9C5G3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:GBP7
gene id: 9597:GBP7
uniprot id: A0A2R8ZYF8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9597:MMAB
gene id: 9597:MMAB
uniprot id: A0A2R9ANE0
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

9597:RAF1
gene id: 9597:RAF1
uniprot id: A0A2R9B7H5
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9597:EOGT
gene id: 9597:EOGT
uniprot id: A0A2R9BZ03
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

9597:CHM
gene id: 9597:CHM
uniprot id: A0A2R9B236
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9597:ZDHHC22
gene id: 9597:ZDHHC22
uniprot id: A0A2R8ZHJ0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9597:GIMAP6
gene id: 9597:GIMAP6
uniprot id: A0A2R9AXZ2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9597:FNIP2
gene id: 9597:FNIP2
uniprot id: A0A2R9ACN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9597:FNIP1
gene id: 9597:FNIP1
uniprot id: A0A2R9BYV7
uniprot id: A0A2R9C233
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9597:TNFRSF25
gene id: 9597:TNFRSF25
uniprot id: A0A2R9BER1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TNFRSF14
gene id: 9597:TNFRSF14
uniprot id: A0A2R9C593
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:MRPS25
gene id: 9597:MRPS25
uniprot id: A0A2R9BU01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9597:LYVE1
gene id: 9597:LYVE1
uniprot id: A0A2R9BYT0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:RHCG
gene id: 9597:RHCG
uniprot id: A0A2R9C1Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9597:TRAK2
gene id: 9597:TRAK2
uniprot id: A0A2R9B948
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9597:LOC100977441
gene id: 9597:LOC100977441
uniprot id: A0A2R9AN85
names: Similarity
messages: Belongs to the cytochrome b5 family.

9597:KCNG1
gene id: 9597:KCNG1
uniprot id: A0A2R9AKC5
names: Subcellular Location Annotation
messages: Membrane

9597:UIMC1
gene id: 9597:UIMC1
uniprot id: A0A2R9B8V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

9597:MRPL51
gene id: 9597:MRPL51
uniprot id: A0A2R9BXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Mitochondrion

9597:BCHE
gene id: 9597:BCHE
uniprot id: A0A2R9BEU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9597:LIN28B
gene id: 9597:LIN28B
uniprot id: A0A2R9BPJ2
uniprot id: A0A2R9BPL2
names: Similarity
messages: Belongs to the lin-28 family.

9597:PREB
gene id: 9597:PREB
uniprot id: A0A2R9A6R4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9597:DAG1
gene id: 9597:DAG1
uniprot id: A0A2R9BAV6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9597:DGLUCY
gene id: 9597:DGLUCY
uniprot id: A0A2R9AQG9
uniprot id: A0A2R9AQH5
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

9597:STXBP5
gene id: 9597:STXBP5
uniprot id: A0A2R9AW10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9597:WSCD1
gene id: 9597:WSCD1
uniprot id: A0A2R9CDK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Golgi apparatus membrane
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

9597:DDX3X
gene id: 9597:DDX3X
uniprot id: A0A2R9C920
names: Similarity
messages: Belongs to the DEAD box helicase family.

9597:LOC100974054
gene id: 9597:LOC100974054
uniprot id: A0A2R8Z6W3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:TMEM151A
gene id: 9597:TMEM151A
uniprot id: A0A2R9AY98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9597:HSD17B6
gene id: 9597:HSD17B6
uniprot id: A0A2R9A4K9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9597:MESD
gene id: 9597:MESD
uniprot id: A0A2R8ZE28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

9597:CYP2B6
gene id: 9597:CYP2B6
uniprot id: A0A2R9AIM3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9597:GRIN2A
gene id: 9597:GRIN2A
uniprot id: A0A2R9AYV3
uniprot id: A0A2R9AYX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9597:DTYMK
gene id: 9597:DTYMK
uniprot id: A0A2R9C564
names: Similarity
messages: Belongs to the thymidylate kinase family.

9597:PON2
gene id: 9597:PON2
uniprot id: A0A2R9A6X3
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9597:ITGAM
gene id: 9597:ITGAM
uniprot id: A0A2R9BGM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9597:CACNA1D
gene id: 9597:CACNA1D
uniprot id: A0A2R9CK68
uniprot id: A0A2R9CK78
uniprot id: A0A2R9CMS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9597:SLC16A13
gene id: 9597:SLC16A13
uniprot id: A0A2R9BJE6
names: Subcellular Location Annotation
messages: Membrane

9597:CENPH
gene id: 9597:CENPH
uniprot id: A0A2R9BSG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

9597:XPO6
gene id: 9597:XPO6
uniprot id: A0A2R9AZ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9597:GSTZ1
gene id: 9597:GSTZ1
uniprot id: A0A2R9C487
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9597:PUS10
gene id: 9597:PUS10
uniprot id: A0A2R8ZQ34
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

9597:RSPO1
gene id: 9597:RSPO1
uniprot id: A0A2R9CBB0
names: Similarity
messages: Belongs to the R-spondin family.

9597:ZNF514
gene id: 9597:ZNF514
uniprot id: A0A2R9BJR5
names: Function
messages: May be involved in transcriptional regulation.

9597:SERPINA1
gene id: 9597:SERPINA1
uniprot id: A0A2R9CIS5
names: Similarity
messages: Belongs to the serpin family.

9597:S100A4
gene id: 9597:S100A4
uniprot id: A0A2R8ZE71
names: Similarity
messages: Belongs to the S-100 family.

9597:PCDHB8
gene id: 9597:PCDHB8
uniprot id: A0A2R8ZEH8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:MPP1
gene id: 9597:MPP1
uniprot id: A0A2R9C400
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

9597:ZNF772
gene id: 9597:ZNF772
uniprot id: A0A2R9A2F1
uniprot id: A0A2R9A3W7
names: Function
messages: May be involved in transcriptional regulation.

9597:FBLN5
gene id: 9597:FBLN5
uniprot id: A0A2R9BAT7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CRYBA1
gene id: 9597:CRYBA1
uniprot id: A0A2R8ZFR9
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9597:NXT1
gene id: 9597:NXT1
uniprot id: A0A2R8ZJN6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9597:PPP1R2C
gene id: 9597:PPP1R2C
uniprot id: A0A2R8ZQ88
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9597:NTNG1
gene id: 9597:NTNG1
uniprot id: A0A2R9CK20
uniprot id: A0A2R9CMN7
uniprot id: A0A2R9CSI1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100980965
gene id: 9597:LOC100980965
uniprot id: A0A2R9BFF8
names: Similarity
messages: Belongs to the MHC class I family.

9597:SMAD3
gene id: 9597:SMAD3
uniprot id: A0A2R9AV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9597:NMNAT1
gene id: 9597:NMNAT1
uniprot id: A0A2R9C2A2
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9597:BRINP3
gene id: 9597:BRINP3
uniprot id: A0A2R9CJ41
names: Similarity
messages: Belongs to the BRINP family.

9597:MEOX2
gene id: 9597:MEOX2
uniprot id: A0A2R8ZHB4
names: Subcellular Location Annotation
messages: Nucleus

9597:HM13
gene id: 9597:HM13
uniprot id: A0A2R9AMI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9597:TFAP2B
gene id: 9597:TFAP2B
uniprot id: A0A2R9AMI2
names: Similarity
messages: Belongs to the AP-2 family.

9597:ZNF543
gene id: 9597:ZNF543
uniprot id: A0A2R9B0R2
names: Function
messages: May be involved in transcriptional regulation.

9597:MPPE1
gene id: 9597:MPPE1
uniprot id: A0A2R8ZL51
uniprot id: A0A2R8ZL54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10.
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

9597:SLC25A39
gene id: 9597:SLC25A39
uniprot id: A0A2R9BZD3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9597:KCNK1
gene id: 9597:KCNK1
uniprot id: A0A2R9ACF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

9597:ZFP36
gene id: 9597:ZFP36
uniprot id: A0A2R9AM16
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9597:SMC3
gene id: 9597:SMC3
uniprot id: A0A2R9AH80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

9597:PAX7
gene id: 9597:PAX7
uniprot id: A0A2R9AC01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9597:OTULINL
gene id: 9597:OTULINL
uniprot id: A0A2R8ZJU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9597:CWC25
gene id: 9597:CWC25
uniprot id: A0A2R8ZL90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

9597:KCNJ9
gene id: 9597:KCNJ9
uniprot id: A0A2R9B157
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9597:TXNRD1
gene id: 9597:TXNRD1
uniprot id: A0A2R9AKG2
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

9597:NPVF
gene id: 9597:NPVF
uniprot id: A0A2R8ZFL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

9597:KPNA4
gene id: 9597:KPNA4
uniprot id: A0A2R8ZEY4
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9597:STK40
gene id: 9597:STK40
uniprot id: A0A2R9BTT0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9597:TRIM21
gene id: 9597:TRIM21
uniprot id: A0A2R9CHV1
names: Subcellular Location Annotation
messages: Cytoplasm

9597:LXN
gene id: 9597:LXN
uniprot id: A0A2R9CAF3
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9597:FAM118B
gene id: 9597:FAM118B
uniprot id: A0A2R9A5B6
names: Similarity
messages: Belongs to the FAM118 family.

9597:GDF15
gene id: 9597:GDF15
uniprot id: A0A2R9BNA9
names: Similarity
messages: Belongs to the TGF-beta family.

9597:LOC100970363
gene id: 9597:LOC100970363
uniprot id: A0A2R9BSJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9597:AURKB
gene id: 9597:AURKB
uniprot id: A0A2R9A9B4
uniprot id: A0A2R9A9Y3
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

9597:LOC100983833
gene id: 9597:LOC100983833
uniprot id: A0A2R8ZTV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TNFSF15
gene id: 9597:TNFSF15
uniprot id: A0A2R8ZVZ2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9597:CABS1
gene id: 9597:CABS1
uniprot id: A0A2R8ZB06
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion inner membrane
messages: flagellum

9597:LLPH
gene id: 9597:LLPH
uniprot id: A0A2R9CLC3
names: Similarity
messages: Belongs to the learning-associated protein family.

9597:MPC2
gene id: 9597:MPC2
uniprot id: A0A2R9AMQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9597:MRPS9
gene id: 9597:MRPS9
uniprot id: A0A2R9BGM3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9597:SYT1
gene id: 9597:SYT1
uniprot id: A0A2R9A4D0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

9597:LOC103785886
gene id: 9597:LOC103785886
uniprot id: A0A2R8ZKJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:LOC100981041
gene id: 9597:LOC100981041
uniprot id: A0A2R9APZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SSTR2
gene id: 9597:SSTR2
uniprot id: A0A2R8ZAV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9597:PADI2
gene id: 9597:PADI2
uniprot id: A0A2R9BZA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9597:TNNT3
gene id: 9597:TNNT3
uniprot id: A0A2R9ARJ3
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9597:ARCN1
gene id: 9597:ARCN1
uniprot id: A0A2R8ZXI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9597:SEC24D
gene id: 9597:SEC24D
uniprot id: A0A2R9A1R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9597:LOC100995226
gene id: 9597:LOC100995226
uniprot id: A0A2R9CGS3
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Lysosome membrane

9597:CSNK1G1
gene id: 9597:CSNK1G1
uniprot id: A0A2R9BBQ7
uniprot id: A0A2R9BBS5
uniprot id: A0A2R9BFG2
uniprot id: A0A2R9BFH2
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9597:CRYBG3
gene id: 9597:CRYBG3
uniprot id: A0A2R9BY08
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9597:PCMTD1
gene id: 9597:PCMTD1
uniprot id: A0A2R8ZA41
uniprot id: A0A2R8ZAJ3
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9597:IAPP
gene id: 9597:IAPP
uniprot id: A0A2R9ATQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted
messages: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

9597:DHDH
gene id: 9597:DHDH
uniprot id: A0A2R9BFW6
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9597:VSIG1
gene id: 9597:VSIG1
uniprot id: A0A2R9B5R4
names: Subcellular Location Annotation
messages: Membrane

9597:FOXN1
gene id: 9597:FOXN1
uniprot id: A0A2R9CR70
names: Subcellular Location Annotation
messages: Nucleus

9597:LOC103784797
gene id: 9597:LOC103784797
uniprot id: A0A2R8ZQL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

9597:MCMBP
gene id: 9597:MCMBP
uniprot id: A0A2R9C673
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

9597:ZFHX2
gene id: 9597:ZFHX2
uniprot id: A0A2R9BVA3
names: Subcellular Location Annotation
messages: Nucleus

9597:CXCL9
gene id: 9597:CXCL9
uniprot id: A0A2R9BUU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:CASP9
gene id: 9597:CASP9
uniprot id: A0A2R9CHF2
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:FOXN2
gene id: 9597:FOXN2
uniprot id: A0A2R9BEA1
names: Subcellular Location Annotation
messages: Nucleus

9597:TYROBP
gene id: 9597:TYROBP
uniprot id: A0A2R9C1E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

9597:UBLCP1
gene id: 9597:UBLCP1
uniprot id: A0A2R9AF35
names: Subcellular Location Annotation
messages: Nucleus

9597:PF4V1
gene id: 9597:PF4V1
uniprot id: A0A2R8ZN72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9597:MED27
gene id: 9597:MED27
uniprot id: A0A2R9CFW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9597:TRMU
gene id: 9597:TRMU
uniprot id: A0A2R9AVX0
uniprot id: A0A2R9AZY4
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

9597:FAM168A
gene id: 9597:FAM168A
uniprot id: A0A2R9CEJ3
names: Similarity
messages: Belongs to the FAM168 family.

9597:SMOC2
gene id: 9597:SMOC2
uniprot id: A0A2R9BJ17
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:MPP7
gene id: 9597:MPP7
uniprot id: A0A2R9AP32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

9597:MRPL52
gene id: 9597:MRPL52
uniprot id: A0A2R9AYJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

9597:RELL1
gene id: 9597:RELL1
uniprot id: A0A2R9AH43
names: Similarity
messages: Belongs to the RELT family.

9597:POLE
gene id: 9597:POLE
uniprot id: A0A2R9AX07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

9597:PLXNB3
gene id: 9597:PLXNB3
uniprot id: A0A2R9A7S3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:FEN1
gene id: 9597:FEN1
uniprot id: A0A2R8ZQP1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Mitochondrion
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9597:PMS1
gene id: 9597:PMS1
uniprot id: A0A2R8ZD19
uniprot id: A0A2R8ZD34
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9597:LOC100993343
gene id: 9597:LOC100993343
uniprot id: A0A2R8ZGT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:GPR89A
gene id: 9597:GPR89A
uniprot id: A0A2R9A501
uniprot id: A0A2R9A672
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9597:PIGN
gene id: 9597:PIGN
uniprot id: A0A2R9BVL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:LANCL1
gene id: 9597:LANCL1
uniprot id: A0A2R9BWF6
names: Similarity
messages: Belongs to the LanC-like protein family.

9597:TJAP1
gene id: 9597:TJAP1
uniprot id: A0A2R9A7C1
uniprot id: A0A2R9A7D7
names: Subcellular Location Annotation
messages: Membrane

9597:SNRPA
gene id: 9597:SNRPA
uniprot id: A0A2R9AYG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM U1 A/B'' family.
messages: Nucleus

9597:SARAF
gene id: 9597:SARAF
uniprot id: A0A2R9ANW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9597:NOXA1
gene id: 9597:NOXA1
uniprot id: A0A2R9BG68
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9597:RAD23A
gene id: 9597:RAD23A
uniprot id: A0A2R8ZJH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9597:NCEH1
gene id: 9597:NCEH1
uniprot id: A0A2R8ZF52
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9597:SGMS2
gene id: 9597:SGMS2
uniprot id: A0A2R9C4A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9597:MGAM2
gene id: 9597:MGAM2
uniprot id: A0A2R9B3A5
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:CSRNP1
gene id: 9597:CSRNP1
uniprot id: A0A2R9CD71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9597:CREBL2
gene id: 9597:CREBL2
uniprot id: A0A2R8ZR97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9597:SLC7A2
gene id: 9597:SLC7A2
uniprot id: A0A2R8ZFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9597:SF3A3
gene id: 9597:SF3A3
uniprot id: A0A2R9AX82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3A3 family.
messages: Nucleus

9597:FGD3
gene id: 9597:FGD3
uniprot id: A0A2R9A912
names: Subcellular Location Annotation
messages: cytoskeleton

9597:TAFA4
gene id: 9597:TAFA4
uniprot id: A0A2R9BU10
names: Similarity
messages: Belongs to the TAFA family.

9597:LOC100976754
gene id: 9597:LOC100976754
uniprot id: A0A2R9C0I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9597:PRMT5
gene id: 9597:PRMT5
uniprot id: A0A2R9AKS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9597:MCM6
gene id: 9597:MCM6
uniprot id: A0A2R8ZL26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9597:FAM131A
gene id: 9597:FAM131A
uniprot id: A0A2R9BJG3
names: Similarity
messages: Belongs to the FAM131 family.

9597:TPPP3
gene id: 9597:TPPP3
uniprot id: A0A2R9BVJ5
names: Similarity
messages: Belongs to the TPPP family.

9597:LOC100983071
gene id: 9597:LOC100983071
uniprot id: A0A2R9C1C8
names: Similarity
messages: Belongs to the CBP3 family.

9597:ING4
gene id: 9597:ING4
uniprot id: A0A2R9B458
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9597:MYOF
gene id: 9597:MYOF
uniprot id: A0A2R9C196
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9597:CD40LG
gene id: 9597:CD40LG
uniprot id: A0A2R9CD52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

9597:ADCY8
gene id: 9597:ADCY8
uniprot id: A0A2R9BI25
uniprot id: A0A2R9BKQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9597:UROD
gene id: 9597:UROD
uniprot id: A0A2R9B7D3
uniprot id: A0A2R9BB53
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

9597:DHDDS
gene id: 9597:DHDDS
uniprot id: A0A2R9AFF5
uniprot id: A0A2R9AFF8
names: Similarity
messages: Belongs to the UPP synthase family.

9597:RELN
gene id: 9597:RELN
uniprot id: A0A2R9B232
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the reelin family.
messages: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.
messages: extracellular matrix

9597:RIN1
gene id: 9597:RIN1
uniprot id: A0A2R9AZU9
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9597:DMAP1
gene id: 9597:DMAP1
uniprot id: A0A2R9BEF6
names: Subcellular Location Annotation
messages: Nucleus

9597:NTMT2
gene id: 9597:NTMT2
uniprot id: A0A2R8ZYR2
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9597:LOC100986809
gene id: 9597:LOC100986809
uniprot id: A0A2R9B346
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9597:LOC100974017
gene id: 9597:LOC100974017
uniprot id: A0A2R8ZT84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TPD52
gene id: 9597:TPD52
uniprot id: A0A2R9BQP3
names: Similarity
messages: Belongs to the TPD52 family.

9597:RNF167
gene id: 9597:RNF167
uniprot id: A0A2R9BN69
names: Subcellular Location Annotation
messages: Membrane

9597:NARF
gene id: 9597:NARF
uniprot id: A0A2R9BB87
names: Similarity
messages: Belongs to the NARF family.

9597:CFAP107
gene id: 9597:CFAP107
uniprot id: A0A2R9ASN0
uniprot id: A0A2R9AX14
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

9597:SLC2A11
gene id: 9597:SLC2A11
uniprot id: A0A2R9A1R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane

9597:BEST2
gene id: 9597:BEST2
uniprot id: A0A2R9BDZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9597:CCNDBP1
gene id: 9597:CCNDBP1
uniprot id: A0A2R9B143
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

9597:UGCG
gene id: 9597:UGCG
uniprot id: A0A2R9CLW0
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9597:TRAF1
gene id: 9597:TRAF1
uniprot id: A0A2R9C863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9597:ERBB2
gene id: 9597:ERBB2
uniprot id: A0A2R9C656
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9597:INTS13
gene id: 9597:INTS13
uniprot id: A0A2R8ZGQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

9597:USP33
gene id: 9597:USP33
uniprot id: A0A2R9CQ86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9597:REN
gene id: 9597:REN
uniprot id: A0A2R9C0Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Interacts with ATP6AP2.
messages: Membrane
messages: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

9597:LOC100993694
gene id: 9597:LOC100993694
uniprot id: A0A2R8ZCN1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:GMPPA
gene id: 9597:GMPPA
uniprot id: A0A2R8ZVG5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9597:ERF
gene id: 9597:ERF
uniprot id: A0A2R8ZX10
uniprot id: A0A2R9A2L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9597:LOC103784642
gene id: 9597:LOC103784642
uniprot id: A0A2R9AQR0
names: Function
messages: May be involved in transcriptional regulation.

9597:BRPF1
gene id: 9597:BRPF1
uniprot id: A0A2R8ZHL4
uniprot id: A0A2R8ZNV3
names: Subcellular Location Annotation
messages: Nucleus

9597:CORO1C
gene id: 9597:CORO1C
uniprot id: A0A2R9APZ3
names: Similarity
messages: Belongs to the WD repeat coronin family.

9597:ASPDH
gene id: 9597:ASPDH
uniprot id: A0A2R9A749
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9597:EFHB
gene id: 9597:EFHB
uniprot id: A0A2R8ZVE6
names: Subcellular Location Annotation
messages: cilium axoneme

9597:YME1L1
gene id: 9597:YME1L1
uniprot id: A0A2R9C161
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9597:HSDL2
gene id: 9597:HSDL2
uniprot id: A0A2R8Z825
uniprot id: A0A2R8ZEN0
names: Subcellular Location Annotation
messages: Peroxisome

9597:LAMTOR4
gene id: 9597:LAMTOR4
uniprot id: A0A2R9BJ39
names: Similarity
messages: Belongs to the LAMTOR4 family.

9597:TMCO4
gene id: 9597:TMCO4
uniprot id: A0A2R9AHQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

9597:INSIG2
gene id: 9597:INSIG2
uniprot id: A0A2R9AW28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9597:LCA5L
gene id: 9597:LCA5L
uniprot id: A0A2R9B9U9
names: Similarity
messages: Belongs to the LCA5 family.

9597:RSPH3
gene id: 9597:RSPH3
uniprot id: A0A2R8ZDT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flagellar radial spoke RSP3 family.
messages: flagellum axoneme

9597:SKI
gene id: 9597:SKI
uniprot id: A0A2R9AH64
names: Similarity
messages: Belongs to the SKI family.

9597:BLOC1S5
gene id: 9597:BLOC1S5
uniprot id: A0A2R8ZVX5
names: Similarity
messages: Belongs to the BLOC1S5 family.

9597:DUSP9
gene id: 9597:DUSP9
uniprot id: A0A2R9CJK5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9597:ENDOG
gene id: 9597:ENDOG
uniprot id: A0A2R9C4H9
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9597:SLC12A1
gene id: 9597:SLC12A1
uniprot id: A0A2R8Z779
uniprot id: A0A2R8Z783
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9597:CCT4
gene id: 9597:CCT4
uniprot id: A0A2R9BDI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9597:PKIA
gene id: 9597:PKIA
uniprot id: A0A2R8ZIM0
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9597:SULT1C2
gene id: 9597:SULT1C2
uniprot id: A0A2R9BXP4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9597:OPRM1
gene id: 9597:OPRM1
uniprot id: A0A2R9C8J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

9597:PRRC1
gene id: 9597:PRRC1
uniprot id: A0A2R8ZQI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

9597:SH3RF1
gene id: 9597:SH3RF1
uniprot id: A0A2R9AXG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3RF family.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

9597:WTAP
gene id: 9597:WTAP
uniprot id: A0A2R9A685
uniprot id: A0A2R9A694
names: Similarity
messages: Belongs to the fl(2)d family.

9597:C15H15orf40
gene id: 9597:C15H15orf40
uniprot id: A0A2R8ZHU9
names: Similarity
messages: Belongs to the UPF0235 family.

9597:TAX1BP3
gene id: 9597:TAX1BP3
uniprot id: A0A2R8Z7U6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9597:ZNF136
gene id: 9597:ZNF136
uniprot id: A0A2R8ZEJ9
names: Function
messages: May be involved in transcriptional regulation.

9597:SELP
gene id: 9597:SELP
uniprot id: A0A2R9AUS4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:CNTN1
gene id: 9597:CNTN1
uniprot id: A0A2R9B3B9
uniprot id: A0A2R9B741
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9597:GNRHR
gene id: 9597:GNRHR
uniprot id: A0A2R9C7P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:TEAD4
gene id: 9597:TEAD4
uniprot id: A0A2R9BKF7
uniprot id: A0A2R9BUD4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

9597:NUDT12
gene id: 9597:NUDT12
uniprot id: A0A2R9BGH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

9597:CST9
gene id: 9597:CST9
uniprot id: A0A2R9BH73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9597:THOP1
gene id: 9597:THOP1
uniprot id: A0A2R9AKN5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9597:TAC3
gene id: 9597:TAC3
uniprot id: A0A2R9BYU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

9597:PML
gene id: 9597:PML
uniprot id: A0A2R9A6X2
uniprot id: A0A2R9A6Y4
uniprot id: A0A2R9A800
uniprot id: Q15JE2
names: Subcellular Location Annotation
messages: Cytoplasm

9597:DYNC2H1
gene id: 9597:DYNC2H1
uniprot id: A0A2R9BY73
uniprot id: A0A2R9BY90
names: Similarity
messages: Belongs to the dynein heavy chain family.

9597:POMGNT2
gene id: 9597:POMGNT2
uniprot id: A0A2R8ZIF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:CEP63
gene id: 9597:CEP63
uniprot id: A0A2R9B461
uniprot id: A0A2R9B465
names: Similarity
messages: Belongs to the CEP63 family.

9597:TLR7
gene id: 9597:TLR7
uniprot id: B3Y649
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9597:RPL32
gene id: 9597:RPL32
uniprot id: A0A2R8ZDY6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9597:ERLIN1
gene id: 9597:ERLIN1
uniprot id: A0A2R9BCK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9597:ADGRF5
gene id: 9597:ADGRF5
uniprot id: A0A2R9B2W1
uniprot id: A0A2R9B554
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9597:AQP11
gene id: 9597:AQP11
uniprot id: A0A2R9AJT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Membrane

9597:GPR34
gene id: 9597:GPR34
uniprot id: Q3SAG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Orphan receptor.

9597:CXCR4
gene id: 9597:CXCR4
uniprot id: A0A2R9CH84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell junction
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Membrane

9597:LOC100988752
gene id: 9597:LOC100988752
uniprot id: A0A2R8Z8K8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.

9597:HPS3
gene id: 9597:HPS3
uniprot id: A0A2R8ZYI6
uniprot id: A0A2R9A2W9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

9597:LOC100970414
gene id: 9597:LOC100970414
uniprot id: A0A2R8Z7U5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9597:KIF3C
gene id: 9597:KIF3C
uniprot id: A0A2R9BZ98
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:TIMM8B
gene id: 9597:TIMM8B
uniprot id: A0A2R9B6T3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9597:SLC5A8
gene id: 9597:SLC5A8
uniprot id: A0A2R9BLW4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9597:LOC100981014
gene id: 9597:LOC100981014
uniprot id: A0A2R9A7B2
names: Similarity
messages: Belongs to the Bcl-2 family.

9597:CD99
gene id: 9597:CD99
uniprot id: A0A2R9AC51
names: Similarity
messages: Belongs to the CD99 family.

9597:ATP6AP2
gene id: 9597:ATP6AP2
uniprot id: A0A2R9C0U5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9597:ACAP1
gene id: 9597:ACAP1
uniprot id: A0A2R9BF19
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9597:FAM221A
gene id: 9597:FAM221A
uniprot id: A0A2R9C541
uniprot id: A0A2R9C7Y7
uniprot id: A0A2R9CFM5
names: Similarity
messages: Belongs to the FAM221 family.

9597:MMP12
gene id: 9597:MMP12
uniprot id: A0A2R8ZA46
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9597:PKIB
gene id: 9597:PKIB
uniprot id: A0A2R9C8U5
uniprot id: A0A2R9CJI2
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9597:ST6GAL2
gene id: 9597:ST6GAL2
uniprot id: A0A2R9BBT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

9597:EAF2
gene id: 9597:EAF2
uniprot id: A0A2R9CK88
names: Similarity
messages: Belongs to the EAF family.

9597:PIGO
gene id: 9597:PIGO
uniprot id: A0A2R8ZMP4
uniprot id: A0A2R8ZNV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:LOC100971931
gene id: 9597:LOC100971931
uniprot id: A0A2R8ZIZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TAAR6
gene id: 9597:TAAR6
uniprot id: A0A2R8ZH87
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:SBNO1
gene id: 9597:SBNO1
uniprot id: A0A2R8ZN50
names: Similarity
messages: Belongs to the SBNO family.

9597:LOC100974914
gene id: 9597:LOC100974914
uniprot id: A0A2R8ZQ27
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:CALB1
gene id: 9597:CALB1
uniprot id: A0A2R9CNG8
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

9597:SLC39A7
gene id: 9597:SLC39A7
uniprot id: A0A2R8ZZI2
names: Subcellular Location Annotation
messages: Membrane

9597:SH2B3
gene id: 9597:SH2B3
uniprot id: A0A2R9C2F4
names: Similarity
messages: Belongs to the SH2B adapter family.

9597:CASP6
gene id: 9597:CASP6
uniprot id: A0A2R9BHM8
uniprot id: A0A2R9BMA1
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:TENT5C
gene id: 9597:TENT5C
uniprot id: A0A2R8ZMB3
names: Similarity
messages: Belongs to the TENT family.

9597:ZKSCAN4
gene id: 9597:ZKSCAN4
uniprot id: A0A2R9BRT9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9597:ABCB7
gene id: 9597:ABCB7
uniprot id: A0A2R9AL60
names: Subcellular Location Annotation
messages: Membrane

9597:FANCM
gene id: 9597:FANCM
uniprot id: A0A2R9A3N5
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

9597:EIF2A
gene id: 9597:EIF2A
uniprot id: A0A2R9CKE2
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9597:GTF2E2
gene id: 9597:GTF2E2
uniprot id: A0A2R9AHX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9597:POP5
gene id: 9597:POP5
uniprot id: A0A2R9CJZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9597:LMNB1
gene id: 9597:LMNB1
uniprot id: A0A2R9BUC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9597:HAL
gene id: 9597:HAL
uniprot id: A0A2R8Z7Z2
names: Similarity
messages: Belongs to the PAL/histidase family.

9597:GDI2
gene id: 9597:GDI2
uniprot id: A0A2R9A110
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9597:PAX6
gene id: 9597:PAX6
uniprot id: A0A2R9CK82
uniprot id: A0A2R9CMS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9597:LOC100976386
gene id: 9597:LOC100976386
uniprot id: A0A2R9BR08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9597:CHRNB2
gene id: 9597:CHRNB2
uniprot id: A0A2R9AJA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:SLC51A
gene id: 9597:SLC51A
uniprot id: A0A2R9A5Y1
names: Subcellular Location Annotation
messages: Membrane

9597:KXD1
gene id: 9597:KXD1
uniprot id: A0A2R9CNZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9597:RRH
gene id: 9597:RRH
uniprot id: A0A2R9C7I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9597:TATDN1
gene id: 9597:TATDN1
uniprot id: A0A2R9AMK9
uniprot id: A0A2R9AS25
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9597:GPD1
gene id: 9597:GPD1
uniprot id: A0A2R9B4E1
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9597:TRMT2B
gene id: 9597:TRMT2B
uniprot id: A0A2R9BQZ0
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:LOC100981889
gene id: 9597:LOC100981889
uniprot id: A0A2R9AR08
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9597:ZNF264
gene id: 9597:ZNF264
uniprot id: A0A2R9C0V7
names: Function
messages: May be involved in transcriptional regulation.

9597:CALCA
gene id: 9597:CALCA
uniprot id: A0A2R9C2C6
uniprot id: A0A2R9C976
names: Similarity
messages: Belongs to the calcitonin family.

9597:LOC100990116
gene id: 9597:LOC100990116
uniprot id: A0A2R9BWF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9597:APCS
gene id: 9597:APCS
uniprot id: A0A2R9C9Y7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9597:WEE2
gene id: 9597:WEE2
uniprot id: A0A2R8ZJE5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

9597:RBM5
gene id: 9597:RBM5
uniprot id: A0A2R9CIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9597:PDE9A
gene id: 9597:PDE9A
uniprot id: A0A2R8ZW91
uniprot id: A0A2R8ZYF4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:NSUN2
gene id: 9597:NSUN2
uniprot id: A0A2R9B8T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

9597:LOC106633834
gene id: 9597:LOC106633834
uniprot id: A0A2R8ZBU8
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9597:VCL
gene id: 9597:VCL
uniprot id: A0A2R9CAL0
uniprot id: A0A2R9CAL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: podosome

9597:CENPQ
gene id: 9597:CENPQ
uniprot id: A0A2R9BPQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

9597:CREB1
gene id: 9597:CREB1
uniprot id: A0A2R9CEL5
uniprot id: A0A2R9CPF8
names: Subcellular Location Annotation
messages: Nucleus

9597:DDX54
gene id: 9597:DDX54
uniprot id: A0A2R9CAD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: nucleolus

9597:CACFD1
gene id: 9597:CACFD1
uniprot id: A0A2R8ZCF5
uniprot id: A0A2R8ZCX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

9597:MMP26
gene id: 9597:MMP26
uniprot id: A0A2R8ZNE0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9597:RPL38
gene id: 9597:RPL38
uniprot id: A0A2R9AUE2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9597:PPP1R3C
gene id: 9597:PPP1R3C
uniprot id: A0A2R9CHU8
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9597:SUPT6H
gene id: 9597:SUPT6H
uniprot id: A0A2R9BCW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9597:IGBP1
gene id: 9597:IGBP1
uniprot id: A0A2R9CNN9
names: Similarity
messages: Belongs to the IGBP1/TAP42 family.

9597:NOL6
gene id: 9597:NOL6
uniprot id: A0A2R9C5Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: nucleolus

9597:SLA
gene id: 9597:SLA
uniprot id: A0A2R9C909
uniprot id: A0A2R9CJR3
names: Subcellular Location Annotation
messages: Cytoplasm

9597:LCA5
gene id: 9597:LCA5
uniprot id: A0A2R8ZKA0
names: Similarity
messages: Belongs to the LCA5 family.

9597:PYGL
gene id: 9597:PYGL
uniprot id: A0A2R9BC33
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9597:GSS
gene id: 9597:GSS
uniprot id: A0A2R9A4W7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9597:LOC100974537
gene id: 9597:LOC100974537
uniprot id: A0A2R8ZA82
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:ARSI
gene id: 9597:ARSI
uniprot id: A0A2R9BT80
names: Similarity
messages: Belongs to the sulfatase family.

9597:WDR12
gene id: 9597:WDR12
uniprot id: A0A2R9AUR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9597:LOC100993532
gene id: 9597:LOC100993532
uniprot id: A0A2R8Z6Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

9597:GOLPH3L
gene id: 9597:GOLPH3L
uniprot id: A0A2R8ZGS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9597:SCN3B
gene id: 9597:SCN3B
uniprot id: A0A2R9AKY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9597:PSMG1
gene id: 9597:PSMG1
uniprot id: A0A2R9A631
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9597:CHL1
gene id: 9597:CHL1
uniprot id: A0A2R9CK86
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9597:YTHDF2
gene id: 9597:YTHDF2
uniprot id: A0A2R9AVX2
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9597:RBX1
gene id: 9597:RBX1
uniprot id: A0A2R9AIH9
names: Similarity
messages: Belongs to the RING-box family.

9597:SLC22A2
gene id: 9597:SLC22A2
uniprot id: A0A2R8ZD17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane

9597:TUBA4A
gene id: 9597:TUBA4A
uniprot id: A0A2R8ZC21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9597:KCNA10
gene id: 9597:KCNA10
uniprot id: A0A2R8Z7H3
names: Subcellular Location Annotation
messages: Membrane

9597:PMM1
gene id: 9597:PMM1
uniprot id: A0A2R9B4G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9597:PCK1
gene id: 9597:PCK1
uniprot id: A0A2R9BLN9
names: Similarity
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Monomer.

9597:MSMP
gene id: 9597:MSMP
uniprot id: A0A2R9BWC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9597:PPP3CA
gene id: 9597:PPP3CA
uniprot id: A0A2R9CDE3
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9597:ZFP37
gene id: 9597:ZFP37
uniprot id: A0A2R9AB19
names: Function
messages: May be involved in transcriptional regulation.

9597:HARBI1
gene id: 9597:HARBI1
uniprot id: A0A2R9BD15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9597:YARS2
gene id: 9597:YARS2
uniprot id: A0A2R9BFE5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9597:AMOT
gene id: 9597:AMOT
uniprot id: A0A2R9BTE3
names: Similarity
messages: Belongs to the angiomotin family.

9597:SLC26A1
gene id: 9597:SLC26A1
uniprot id: A0A2R9B339
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent sulfate anion transporter. Can transport other anions including bicarbonate, thiosulfate and oxalate.

9597:ZNF408
gene id: 9597:ZNF408
uniprot id: A0A2R9B617
names: Subcellular Location Annotation
messages: Nucleus

9597:POP7
gene id: 9597:POP7
uniprot id: A0A2R8ZIK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9597:ZNF57
gene id: 9597:ZNF57
uniprot id: A0A2R8ZY57
names: Function
messages: May be involved in transcriptional regulation.

9597:MDM1
gene id: 9597:MDM1
uniprot id: A0A2R9AKK3
uniprot id: A0A2R9AKK6
uniprot id: A0A2R9APH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

9597:CEP57
gene id: 9597:CEP57
uniprot id: A0A2R8ZNT7
names: Similarity
messages: Belongs to the translokin family.

9597:PCSK1
gene id: 9597:PCSK1
uniprot id: A0A2R9BI06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9597:MRPS33
gene id: 9597:MRPS33
uniprot id: A0A2R9CQS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9597:GFOD2
gene id: 9597:GFOD2
uniprot id: A0A2R9AJK1
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9597:PNP
gene id: 9597:PNP
uniprot id: A0A2R8ZI70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9597:GJB2
gene id: 9597:GJB2
uniprot id: A0A2R8ZIA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9597:LDAH
gene id: 9597:LDAH
uniprot id: A0A2R8ZM82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

9597:MAT2B
gene id: 9597:MAT2B
uniprot id: A0A2R9CM17
uniprot id: A0A2R9CM31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9597:AEBP1
gene id: 9597:AEBP1
uniprot id: A0A2R8Z8D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9597:RPL36A
gene id: 9597:RPL36A
uniprot id: A0A2R9BCS2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9597:GABRB2
gene id: 9597:GABRB2
uniprot id: A0A2R9C809
uniprot id: A0A2R9C8C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:API5
gene id: 9597:API5
uniprot id: A0A2R9B4I5
names: Similarity
messages: Belongs to the API5 family.

9597:GABRQ
gene id: 9597:GABRQ
uniprot id: A0A2R9ALH2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:CPNE8
gene id: 9597:CPNE8
uniprot id: A0A2R9CL30
names: Similarity
messages: Belongs to the copine family.

9597:CACNB3
gene id: 9597:CACNB3
uniprot id: A0A2R8ZCD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

9597:LBP
gene id: 9597:LBP
uniprot id: A0A2R9B8P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

9597:METTL16
gene id: 9597:METTL16
uniprot id: A0A2R9ADH3
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure.

9597:FAM131B
gene id: 9597:FAM131B
uniprot id: A0A2R9AII7
uniprot id: A0A2R9AMC6
names: Similarity
messages: Belongs to the FAM131 family.

9597:FAM83C
gene id: 9597:FAM83C
uniprot id: A0A2R9BT29
names: Similarity
messages: Belongs to the FAM83 family.

9597:SLC44A2
gene id: 9597:SLC44A2
uniprot id: A0A2R9BUX2
uniprot id: A0A2R9BYB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9597:SF3B3
gene id: 9597:SF3B3
uniprot id: A0A2R8ZRD4
names: Subcellular Location Annotation
messages: Nucleus

9597:RAB9B
gene id: 9597:RAB9B
uniprot id: A0A2R8ZB34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9597:MOGS
gene id: 9597:MOGS
uniprot id: A0A2R8ZMA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

9597:COPE
gene id: 9597:COPE
uniprot id: A0A2R8ZM06
uniprot id: A0A2R8ZQ74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9597:SYN3
gene id: 9597:SYN3
uniprot id: A0A2R9AWU4
names: Similarity
messages: Belongs to the synapsin family.

9597:ATP8B2
gene id: 9597:ATP8B2
uniprot id: A0A2R9AX67
uniprot id: A0A2R9AX93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9597:SFTPC
gene id: 9597:SFTPC
uniprot id: A0A2R9C5L9
names: Function
names: Subcellular Location Annotation
messages: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
messages: surface film

9597:RXRG
gene id: 9597:RXRG
uniprot id: A0A2R9AKU6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9597:C1QBP
gene id: 9597:C1QBP
uniprot id: A0A2R9AAP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Cell membrane

9597:SIX2
gene id: 9597:SIX2
uniprot id: A0A2R9BZP5
names: Subcellular Location Annotation
messages: Nucleus

9597:MTRF1L
gene id: 9597:MTRF1L
uniprot id: A0A2R9AG16
uniprot id: A0A2R9AH06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9597:KCNN4
gene id: 9597:KCNN4
uniprot id: A0A2R9AAT6
names: Subcellular Location Annotation
messages: Membrane

9597:KRT12
gene id: 9597:KRT12
uniprot id: A0A2R9B0H7
names: Similarity
messages: Belongs to the intermediate filament family.

9597:SERPINB5
gene id: 9597:SERPINB5
uniprot id: A0A2R8ZM62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

9597:THNSL2
gene id: 9597:THNSL2
uniprot id: A0A2R9C1Y1
names: Similarity
messages: Belongs to the threonine synthase family.

9597:MRGPRF
gene id: 9597:MRGPRF
uniprot id: A0A2R9A3I5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:KCNA2
gene id: 9597:KCNA2
uniprot id: A0A2R8ZH38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: lamellipodium membrane
messages: paranodal septate junction
messages: synaptosome

9597:GARS1
gene id: 9597:GARS1
uniprot id: A0A2R9BJK5
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

9597:SLC37A2
gene id: 9597:SLC37A2
uniprot id: A0A2R9C7H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9597:DEFB132
gene id: 9597:DEFB132
uniprot id: A0A2R9C956
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9597:PLSCR4
gene id: 9597:PLSCR4
uniprot id: A0A2R9APN3
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9597:CHRNA9
gene id: 9597:CHRNA9
uniprot id: A0A2R8ZXQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9597:RBP7
gene id: 9597:RBP7
uniprot id: A0A2R9AR81
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9597:DNAJA2
gene id: 9597:DNAJA2
uniprot id: A0A2R8ZGS7
names: Subcellular Location Annotation
messages: Membrane

9597:ERGIC3
gene id: 9597:ERGIC3
uniprot id: A0A2R9BEJ5
uniprot id: A0A2R9BN15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9597:LOC100986895
gene id: 9597:LOC100986895
uniprot id: A0A2R8ZGI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:DDRGK1
gene id: 9597:DDRGK1
uniprot id: A0A2R9AVC5
names: Similarity
messages: Belongs to the DDRGK1 family.

9597:DUSP29
gene id: 9597:DUSP29
uniprot id: A0A2R9ABZ0
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9597:ZFP1
gene id: 9597:ZFP1
uniprot id: A0A2R9ARC8
names: Function
messages: May be involved in transcriptional regulation.

9597:THAP1
gene id: 9597:THAP1
uniprot id: A0A2R8ZQX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9597:NDC80
gene id: 9597:NDC80
uniprot id: A0A2R9C428
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9597:UNC50
gene id: 9597:UNC50
uniprot id: A0A2R9BCN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane
messages: Nucleus inner membrane

9597:TAF8
gene id: 9597:TAF8
uniprot id: A0A2R8Z7Q1
uniprot id: A0A2R8Z7R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

9597:RIPOR3
gene id: 9597:RIPOR3
uniprot id: A0A2R9AYW6
names: Similarity
messages: Belongs to the RIPOR family.

9597:IFT57
gene id: 9597:IFT57
uniprot id: A0A2R8ZS71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9597:WDR24
gene id: 9597:WDR24
uniprot id: A0A2R9AEW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR24 family.
messages: Lysosome membrane

9597:SH2D1A
gene id: 9597:SH2D1A
uniprot id: A0A2R9BY26
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

9597:CCNYL1
gene id: 9597:CCNYL1
uniprot id: A0A2R9B0L8
uniprot id: A0A2R9B2L1
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9597:PPP1R11
gene id: 9597:PPP1R11
uniprot id: A0A2R9CI82
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

9597:ELOC
gene id: 9597:ELOC
uniprot id: A0A2R8ZBZ5
names: Similarity
messages: Belongs to the SKP1 family.

9597:RPA1
gene id: 9597:RPA1
uniprot id: A0A2R9BVF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

9597:LAMC1
gene id: 9597:LAMC1
uniprot id: A0A2R9AWQ5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9597:RRP15
gene id: 9597:RRP15
uniprot id: A0A2R9CKV5
names: Similarity
messages: Belongs to the RRP15 family.

9597:SF3B1
gene id: 9597:SF3B1
uniprot id: A0A2R9B2K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

9597:MAPK14
gene id: 9597:MAPK14
uniprot id: A0A2R9C8T7
uniprot id: A0A2R9C8U0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9597:NMUR2
gene id: 9597:NMUR2
uniprot id: A0A2R8ZQR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9597:ARVCF
gene id: 9597:ARVCF
uniprot id: A0A2R8ZT99
names: Similarity
messages: Belongs to the beta-catenin family.

9597:DHX29
gene id: 9597:DHX29
uniprot id: A0A2R9C7X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

9597:RNASE11
gene id: 9597:RNASE11
uniprot id: A0A2R8ZHT0
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9597:TMEM170A
gene id: 9597:TMEM170A
uniprot id: A0A2R9BCJ3
uniprot id: A0A2R9BDW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9597:F2R
gene id: 9597:F2R
uniprot id: A0A2R9B5R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:VPS18
gene id: 9597:VPS18
uniprot id: A0A2R9AJI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9597:GIMAP5
gene id: 9597:GIMAP5
uniprot id: A0A2R9CC68
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9597:ATP23
gene id: 9597:ATP23
uniprot id: A0A2R9B683
names: Similarity
messages: Belongs to the peptidase M76 family.

9597:BARX2
gene id: 9597:BARX2
uniprot id: A0A2R9A129
names: Subcellular Location Annotation
messages: Nucleus

9597:ETF1
gene id: 9597:ETF1
uniprot id: A0A2R9C1R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

9597:LOC100976647
gene id: 9597:LOC100976647
uniprot id: A0A2R8ZPJ4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:EEF1AKMT3
gene id: 9597:EEF1AKMT3
uniprot id: A0A2R9CI70
uniprot id: A0A2R9CI74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

9597:EIF1
gene id: 9597:EIF1
uniprot id: A0A2R9B599
names: Similarity
messages: Belongs to the SUI1 family.

9597:POFUT2
gene id: 9597:POFUT2
uniprot id: A0A2R9B3F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 68 family.
messages: Endoplasmic reticulum

9597:S100A9
gene id: 9597:S100A9
uniprot id: A0A2R9A6I5
names: Similarity
messages: Belongs to the S-100 family.

9597:JUNB
gene id: 9597:JUNB
uniprot id: A0A2R8ZP35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9597:RPL27
gene id: 9597:RPL27
uniprot id: A0A2R8ZYE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9597:GHSR
gene id: 9597:GHSR
uniprot id: A0A2R9A7D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9597:ACTL7A
gene id: 9597:ACTL7A
uniprot id: A0A2R8ZG05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

9597:KCNT2
gene id: 9597:KCNT2
uniprot id: A0A2R9ASQ1
uniprot id: A0A2R9AX18
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:POU1F1
gene id: 9597:POU1F1
uniprot id: A0A2R9BLP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9597:NDUFB1
gene id: 9597:NDUFB1
uniprot id: A0A2R9CS99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9597:SLC22A7
gene id: 9597:SLC22A7
uniprot id: A0A2R9BNG5
names: Subcellular Location Annotation
messages: Membrane

9597:ATP6V0B
gene id: 9597:ATP6V0B
uniprot id: A0A2R9BVN4
uniprot id: A0A2R9BZ25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9597:LOC100970534
gene id: 9597:LOC100970534
uniprot id: A0A2R9B892
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

9597:CREM
gene id: 9597:CREM
uniprot id: A0A2R9BJV5
names: Subcellular Location Annotation
messages: Nucleus

9597:PGF
gene id: 9597:PGF
uniprot id: A0A2R9AEK8
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9597:PDCL3
gene id: 9597:PDCL3
uniprot id: A0A2R9BVE8
names: Similarity
messages: Belongs to the phosducin family.

9597:THG1L
gene id: 9597:THG1L
uniprot id: A0A2R9CC24
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

9597:C10H10orf53
gene id: 9597:C10H10orf53
uniprot id: A0A2R9AZX4
names: Similarity
messages: Belongs to the UPF0728 family.

9597:CPT2
gene id: 9597:CPT2
uniprot id: A0A2R9BDL0
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9597:PDGFRA
gene id: 9597:PDGFRA
uniprot id: A0A2R9AK21
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9597:GPR157
gene id: 9597:GPR157
uniprot id: A0A2R9AW71
names: Subcellular Location Annotation
messages: Membrane

9597:KIF3A
gene id: 9597:KIF3A
uniprot id: A0A2R9BDL2
uniprot id: A0A2R9BKR0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:PIK3R1
gene id: 9597:PIK3R1
uniprot id: A0A2R9CCM8
uniprot id: A0A2R9CCN6
uniprot id: A0A2R9CKR4
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9597:PPFIBP1
gene id: 9597:PPFIBP1
uniprot id: A0A2R9B1G1
uniprot id: A0A2R9B1G5
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9597:CEMIP
gene id: 9597:CEMIP
uniprot id: A0A2R9BTS9
names: Similarity
messages: Belongs to the CEMIP family.

9597:PARP16
gene id: 9597:PARP16
uniprot id: A0A2R9AA47
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:CTNND2
gene id: 9597:CTNND2
uniprot id: A0A2R9AW02
names: Similarity
messages: Belongs to the beta-catenin family.

9597:ACTN3
gene id: 9597:ACTN3
uniprot id: A0A2R8ZKX8
names: Similarity
messages: Belongs to the alpha-actinin family.

9597:LOC100993131
gene id: 9597:LOC100993131
uniprot id: A0A2R9AF88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

9597:ASXL2
gene id: 9597:ASXL2
uniprot id: A0A2R9C392
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9597:TNFSF4
gene id: 9597:TNFSF4
uniprot id: A0A2R9AKM1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9597:HVCN1
gene id: 9597:HVCN1
uniprot id: A0A2R9AXA4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9597:TVP23A
gene id: 9597:TVP23A
uniprot id: A0A2R9B555
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9597:SHOX2
gene id: 9597:SHOX2
uniprot id: A0A2R8ZKC9
names: Subcellular Location Annotation
messages: Nucleus

9597:CHST8
gene id: 9597:CHST8
uniprot id: A0A2R9ABJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9597:CDC42EP2
gene id: 9597:CDC42EP2
uniprot id: A0A2R8ZHL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9597:YDJC
gene id: 9597:YDJC
uniprot id: A0A2R9BHB6
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

9597:ARAF
gene id: 9597:ARAF
uniprot id: A0A2R8ZFY7
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9597:ZIC1
gene id: 9597:ZIC1
uniprot id: A0A2R9B6P4
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9597:MRPL54
gene id: 9597:MRPL54
uniprot id: A0A2R9CEJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9597:ARL3
gene id: 9597:ARL3
uniprot id: A0A2R9B1Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9597:LOC100992969
gene id: 9597:LOC100992969
uniprot id: A0A2R9AZ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9597:USH2A
gene id: 9597:USH2A
uniprot id: A0A2R9ADY7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:XRN1
gene id: 9597:XRN1
uniprot id: A0A2R8ZBD9
uniprot id: A0A2R8ZI65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

9597:KCNE5
gene id: 9597:KCNE5
uniprot id: A0A2R8ZNK6
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9597:SMIM5
gene id: 9597:SMIM5
uniprot id: A0A2R9B3M0
names: Subcellular Location Annotation
messages: Membrane

9597:FZD3
gene id: 9597:FZD3
uniprot id: A0A2R9AS81
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:MTMR3
gene id: 9597:MTMR3
uniprot id: A0A2R9BKZ8
uniprot id: A0A2R9BR39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9597:DRC7
gene id: 9597:DRC7
uniprot id: A0A2R9BR68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

9597:CLDN11
gene id: 9597:CLDN11
uniprot id: A0A2R8ZNI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9597:MIF
gene id: 9597:MIF
uniprot id: A0A2R9AQ00
names: Similarity
messages: Belongs to the MIF family.

9597:MAP3K7
gene id: 9597:MAP3K7
uniprot id: A0A2R8ZW71
uniprot id: A0A2R8ZZW1
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9597:IFI30
gene id: 9597:IFI30
uniprot id: A0A2R9AX29
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

9597:HDHD2
gene id: 9597:HDHD2
uniprot id: A0A2R9A4W0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9597:FOXP3
gene id: 9597:FOXP3
uniprot id: A0A2R8ZXV7
names: Subcellular Location Annotation
messages: Nucleus

9597:TMEM45B
gene id: 9597:TMEM45B
uniprot id: A0A2R9AI60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9597:LHFPL5
gene id: 9597:LHFPL5
uniprot id: A0A2R9AIW5
names: Subcellular Location Annotation
messages: Membrane

9597:RIGI
gene id: 9597:RIGI
uniprot id: A0A2R9CAP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9597:ENTPD7
gene id: 9597:ENTPD7
uniprot id: A0A2R9B779
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9597:PSMC1
gene id: 9597:PSMC1
uniprot id: A0A2R9A6J0
names: Similarity
messages: Belongs to the AAA ATPase family.

9597:NUP133
gene id: 9597:NUP133
uniprot id: A0A2R9B384
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

9597:DLGAP1
gene id: 9597:DLGAP1
uniprot id: A0A2R9AP48
uniprot id: A0A2R9ATN1
uniprot id: A0A2R9AW07
names: Similarity
messages: Belongs to the SAPAP family.

9597:PTCD3
gene id: 9597:PTCD3
uniprot id: A0A2R9A0B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9597:SPP2
gene id: 9597:SPP2
uniprot id: A0A2R9AEB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Secreted

9597:ERMN
gene id: 9597:ERMN
uniprot id: A0A2R9AT88
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

9597:VKORC1
gene id: 9597:VKORC1
uniprot id: A0A2R9BGD1
uniprot id: A0A2R9BK20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9597:BANF1
gene id: 9597:BANF1
uniprot id: A0A2R8Z607
names: Subcellular Location Annotation
messages: Nucleus

9597:PDE1C
gene id: 9597:PDE1C
uniprot id: A0A2R9CEK6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9597:PCLAF
gene id: 9597:PCLAF
uniprot id: A0A2R8ZLE4
uniprot id: A0A2R8ZRF7
names: Subcellular Location Annotation
messages: Nucleus
messages: perinuclear region

9597:CLCN4
gene id: 9597:CLCN4
uniprot id: A0A2R8Z8M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9597:SYT2
gene id: 9597:SYT2
uniprot id: A0A2R9BB69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

9597:GDNF
gene id: 9597:GDNF
uniprot id: A0A2R8ZDG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Homodimer; disulfide-linked.
messages: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
messages: Secreted

9597:GNAO1
gene id: 9597:GNAO1
uniprot id: A0A2R9C7L7
uniprot id: A0A2R9CI50
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9597:DDAH1
gene id: 9597:DDAH1
uniprot id: A0A2R9ATQ6
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9597:TNKS2
gene id: 9597:TNKS2
uniprot id: A0A2R9BZG6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9597:DDI2
gene id: 9597:DDI2
uniprot id: A0A2R9BMW9
names: Similarity
messages: Belongs to the DDI1 family.

9597:CLCN5
gene id: 9597:CLCN5
uniprot id: A0A2R9A9A7
uniprot id: A0A2R9AD48
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:CCBE1
gene id: 9597:CCBE1
uniprot id: A0A2R9AMQ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TSPAN31
gene id: 9597:TSPAN31
uniprot id: A0A2R8ZMC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:MINAR1
gene id: 9597:MINAR1
uniprot id: A0A2R9BXS2
names: Similarity
messages: Belongs to the MINAR family.

9597:DKK2
gene id: 9597:DKK2
uniprot id: A0A2R9BQD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9597:TRAM1
gene id: 9597:TRAM1
uniprot id: A0A2R8ZD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9597:CHRDL1
gene id: 9597:CHRDL1
uniprot id: A0A2R9ASZ3
names: Subcellular Location Annotation
messages: Secreted

9597:PPOX
gene id: 9597:PPOX
uniprot id: A0A2R9B4Z3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

9597:APEX2
gene id: 9597:APEX2
uniprot id: A0A2R9B6M2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9597:SOST
gene id: 9597:SOST
uniprot id: A0A2R9C057
names: Similarity
messages: Belongs to the sclerostin family.

9597:ZNF3
gene id: 9597:ZNF3
uniprot id: A0A2R9BXT6
names: Function
messages: May be involved in transcriptional regulation.

9597:PSMB2
gene id: 9597:PSMB2
uniprot id: A0A2R9CIW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9597:ACADSB
gene id: 9597:ACADSB
uniprot id: A0A2R9BHF8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9597:CCDC47
gene id: 9597:CCDC47
uniprot id: A0A2R9BY68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC47 family.
messages: Rough endoplasmic reticulum membrane

9597:CFAP298
gene id: 9597:CFAP298
uniprot id: A0A2R8ZEI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9597:MTFMT
gene id: 9597:MTFMT
uniprot id: A0A2R9B368
names: Similarity
messages: Belongs to the Fmt family.

9597:PNPO
gene id: 9597:PNPO
uniprot id: A0A2R9BKX3
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

9597:SLX4
gene id: 9597:SLX4
uniprot id: A0A2R9CIP7
names: Similarity
messages: Belongs to the SLX4 family.

9597:DYNLT2B
gene id: 9597:DYNLT2B
uniprot id: A0A2R9AQS6
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9597:GSN
gene id: 9597:GSN
uniprot id: A0A2R9AWD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the villin/gelsolin family.
messages: Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts with the inactive form of EIF2AK2/PKR.
messages: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
messages: cytoskeleton

9597:SLC7A13
gene id: 9597:SLC7A13
uniprot id: A0A2R9B2C4
names: Subcellular Location Annotation
messages: Membrane

9597:RHBDD1
gene id: 9597:RHBDD1
uniprot id: A0A2R9CS20
names: Subcellular Location Annotation
messages: Membrane

9597:AQP2
gene id: 9597:AQP2
uniprot id: A0A2R9CFL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9597:MCM5
gene id: 9597:MCM5
uniprot id: A0A2R9C800
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9597:MRPL30
gene id: 9597:MRPL30
uniprot id: A0A2R9BUE6
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9597:UHRF2
gene id: 9597:UHRF2
uniprot id: A0A2R8ZWP2
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

9597:RETN
gene id: 9597:RETN
uniprot id: A0A2R9BC99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9597:PLRG1
gene id: 9597:PLRG1
uniprot id: A0A2R9AGK3
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9597:POC5
gene id: 9597:POC5
uniprot id: A0A2R9BIF3
uniprot id: A0A2R9BLY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POC5 family.
messages: Essential for the assembly of the distal half of centrioles, required for centriole elongation.
messages: centriole

9597:MRPL12
gene id: 9597:MRPL12
uniprot id: A0A2R9C9I4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9597:PPIL4
gene id: 9597:PPIL4
uniprot id: A0A2R9CL43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9597:LOC100977810
gene id: 9597:LOC100977810
uniprot id: A0A2R8ZLX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:ACSM3
gene id: 9597:ACSM3
uniprot id: A0A2R9BG72
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9597:RAP2B
gene id: 9597:RAP2B
uniprot id: A0A2R8ZU86
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9597:SNX4
gene id: 9597:SNX4
uniprot id: A0A2R9A0S2
names: Similarity
messages: Belongs to the sorting nexin family.

9597:YIF1B
gene id: 9597:YIF1B
uniprot id: A0A2R9ARV2
uniprot id: A0A2R9ASB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9597:KRT73
gene id: 9597:KRT73
uniprot id: A0A2R9BRC5
names: Similarity
messages: Belongs to the intermediate filament family.

9597:PDZK1IP1
gene id: 9597:PDZK1IP1
uniprot id: A0A2R9ATJ4
names: Subcellular Location Annotation
messages: Membrane

9597:PDYN
gene id: 9597:PDYN
uniprot id: A0A2R9AML7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opioid activity and may have anti-apoptotic effect.
messages: Secreted

9597:LOC100973450
gene id: 9597:LOC100973450
uniprot id: A0A2R9ASJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:STX18
gene id: 9597:STX18
uniprot id: A0A2R9AW89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

9597:PKD1L3
gene id: 9597:PKD1L3
uniprot id: A0A2R9A437
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9597:LSM3
gene id: 9597:LSM3
uniprot id: A0A2R9AX57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9597:SPATA6
gene id: 9597:SPATA6
uniprot id: A0A2R9A2H9
names: Similarity
messages: Belongs to the SPATA6 family.

9597:NAT9
gene id: 9597:NAT9
uniprot id: A0A2R9BZU6
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

9597:LOC100971814
gene id: 9597:LOC100971814
uniprot id: A0A2R8Z5R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:XRN2
gene id: 9597:XRN2
uniprot id: A0A2R9ATM4
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9597:APTX
gene id: 9597:APTX
uniprot id: A0A2R9ABN2
names: Subcellular Location Annotation
messages: nucleolus
messages: nucleoplasm

9597:NMT1
gene id: 9597:NMT1
uniprot id: A0A2R9BQM1
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9597:LOC103783322
gene id: 9597:LOC103783322
uniprot id: P60181
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9597:LOC100985787
gene id: 9597:LOC100985787
uniprot id: A0A2R8ZE56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:SYNE4
gene id: 9597:SYNE4
uniprot id: A0A2R9AW54
uniprot id: A0A2R9AZY2
names: Similarity
messages: Belongs to the nesprin family.

9597:NOTO
gene id: 9597:NOTO
uniprot id: A0A2R9B8T8
names: Subcellular Location Annotation
messages: Nucleus

9597:MS4A4A
gene id: 9597:MS4A4A
uniprot id: A0A2R9A3J7
uniprot id: A0A2R9A7T1
names: Similarity
messages: Belongs to the MS4A family.

9597:HDHD3
gene id: 9597:HDHD3
uniprot id: A0A2R8ZBN3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9597:WNT7A
gene id: 9597:WNT7A
uniprot id: A0A2R9AAY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9597:NAA60
gene id: 9597:NAA60
uniprot id: A0A2R9BVX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane

9597:LOC100967245
gene id: 9597:LOC100967245
uniprot id: A0A2R9AY08
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9597:CD55
gene id: 9597:CD55
uniprot id: A0A2R9BRM3
uniprot id: A0A2R9BSA1
uniprot id: A0A2R9C0P9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:TMEM147
gene id: 9597:TMEM147
uniprot id: A0A2R9BXH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM147 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

9597:AK4
gene id: 9597:AK4
uniprot id: A0A2R9BKT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

9597:PGGT1B
gene id: 9597:PGGT1B
uniprot id: A0A2R9C2S9
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

9597:LOC100967703
gene id: 9597:LOC100967703
uniprot id: A0A2R9BJI5
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9597:IFNA8
gene id: 9597:IFNA8
uniprot id: A0A2R8ZIR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9597:KIF18A
gene id: 9597:KIF18A
uniprot id: A0A2R9B2F7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9597:CTSK
gene id: 9597:CTSK
uniprot id: A0A2R9C710
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9597:THNSL1
gene id: 9597:THNSL1
uniprot id: A0A2R8ZAN4
names: Similarity
messages: Belongs to the threonine synthase family.

9597:DIMT1
gene id: 9597:DIMT1
uniprot id: A0A2R9AYI1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9597:NPNT
gene id: 9597:NPNT
uniprot id: A0A2R9AYJ2
uniprot id: A0A2R9AZC1
uniprot id: A0A2R9B4L9
uniprot id: A0A2R9B4M3
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9597:FAM133A
gene id: 9597:FAM133A
uniprot id: A0A2R8ZJW3
names: Similarity
messages: Belongs to the FAM133 family.

9597:ZSCAN21
gene id: 9597:ZSCAN21
uniprot id: A1YG26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Strong transcriptional activator (By similarity). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity).

9597:GNPNAT1
gene id: 9597:GNPNAT1
uniprot id: A0A2R9AAM1
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9597:PRRX1
gene id: 9597:PRRX1
uniprot id: A0A2R9AGJ6
uniprot id: A0A2R9AKE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9597:FAM124B
gene id: 9597:FAM124B
uniprot id: A0A2R8Z6X8
names: Similarity
messages: Belongs to the FAM124 family.

9597:TEX10
gene id: 9597:TEX10
uniprot id: A0A2R9BF55
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

9597:CYP2G2
gene id: 9597:CYP2G2
uniprot id: A0A2R9C0G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9597:ABCG1
gene id: 9597:ABCG1
uniprot id: A0A2R8ZSK2
uniprot id: A0A2R8ZTR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9597:CHRM1
gene id: 9597:CHRM1
uniprot id: A0A2R8ZHH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9597:SLC25A46
gene id: 9597:SLC25A46
uniprot id: A0A2R9CDF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

9597:GTDC1
gene id: 9597:GTDC1
uniprot id: A0A2R9AZJ0
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

9597:ARAP2
gene id: 9597:ARAP2
uniprot id: A0A2R9C069
names: Subcellular Location Annotation
messages: Cytoplasm

9597:GFOD1
gene id: 9597:GFOD1
uniprot id: A0A2R9ABE3
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9597:GPAM
gene id: 9597:GPAM
uniprot id: A0A2R9BMB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

9597:ZC3H14
gene id: 9597:ZC3H14
uniprot id: A0A2R9B8Q9
uniprot id: A0A2R9B8S2
uniprot id: A0A2R9BB29
uniprot id: A0A2R9BEP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZC3H14 family.
messages: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
messages: Nucleus speckle

9597:GDI1
gene id: 9597:GDI1
uniprot id: A0A2R8ZWZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9597:TPRKB
gene id: 9597:TPRKB
uniprot id: A0A2R9ALN7
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9597:RGS9
gene id: 9597:RGS9
uniprot id: A0A2R9A6Z8
names: Subcellular Location Annotation
messages: Membrane

9597:CNEP1R1
gene id: 9597:CNEP1R1
uniprot id: A0A2R8ZX45
uniprot id: A0A2R9A0V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9597:HMBOX1
gene id: 9597:HMBOX1
uniprot id: A0A2R8ZTM2
uniprot id: A0A2R8ZWC2
names: Subcellular Location Annotation
messages: Nucleus

9597:TM7SF3
gene id: 9597:TM7SF3
uniprot id: A0A2R9AXP7
names: Subcellular Location Annotation
messages: Membrane

9597:CRYBB1
gene id: 9597:CRYBB1
uniprot id: A0A2R9A3H6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9597:PGLYRP1
gene id: 9597:PGLYRP1
uniprot id: A0A2R9BV11
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

9597:AP1S1
gene id: 9597:AP1S1
uniprot id: A0A2R9ALL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9597:F2RL2
gene id: 9597:F2RL2
uniprot id: A0A2R9BBE2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9597:C7
gene id: 9597:C7
uniprot id: A0A2R9AYC3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9597:VPS33B
gene id: 9597:VPS33B
uniprot id: A0A2R8ZCW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Early endosome
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9597:SCG5
gene id: 9597:SCG5
uniprot id: A0A2R9CFT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9597:MVD
gene id: 9597:MVD
uniprot id: A0A2R8ZP16
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

9597:MDH2
gene id: 9597:MDH2
uniprot id: A0A2R9AZI0
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

9597:ADCK2
gene id: 9597:ADCK2
uniprot id: A0A2R9AZ50
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9597:FRAS1
gene id: 9597:FRAS1
uniprot id: A0A2R9C9U7
names: Similarity
messages: Belongs to the FRAS1 family.

9597:RABEP2
gene id: 9597:RABEP2
uniprot id: A0A2R9BAQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Cytoplasm
messages: Early endosome
messages: Endosome

9597:BOLA2B
gene id: 9597:BOLA2B
uniprot id: A0A2R9BY10
names: Similarity
messages: Belongs to the BolA/IbaG family.

9597:HOXB1
gene id: 9597:HOXB1
uniprot id: A0A2R9BS21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9597:PTCD2
gene id: 9597:PTCD2
uniprot id: A0A2R8ZZW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

9597:LOC100991996
gene id: 9597:LOC100991996
uniprot id: A0A2R8ZI62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9597:TSPAN18
gene id: 9597:TSPAN18
uniprot id: A0A2R9AHT9
uniprot id: A0A2R9AMI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9597:TAF1A
gene id: 9597:TAF1A
uniprot id: A0A2R9BPT1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9597:MGAT1
gene id: 9597:MGAT1
uniprot id: A0A2R8Z919
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

9597:PREPL
gene id: 9597:PREPL
uniprot id: A0A2R9C8X9
names: Similarity
messages: Belongs to the peptidase S9A family.

9597:RASGRP2
gene id: 9597:RASGRP2
uniprot id: A0A2R9BV52
names: Similarity
messages: Belongs to the RASGRP family.

9597:GNMT
gene id: 9597:GNMT
uniprot id: A0A2R8ZA16
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9597:GASK1B
gene id: 9597:GASK1B
uniprot id: A0A2R9B2M0
names: Similarity
messages: Belongs to the GASK family.

9597:FAH
gene id: 9597:FAH
uniprot id: A0A2R9CIB9
names: Similarity
messages: Belongs to the FAH family.

9597:AKAP3
gene id: 9597:AKAP3
uniprot id: A0A2R9CCE9
names: Similarity
messages: Belongs to the AKAP110 family.

9597:ANXA9
gene id: 9597:ANXA9
uniprot id: A0A2R9B3A6
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9597:SLC25A3
gene id: 9597:SLC25A3
uniprot id: A0A2R9A3S8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9597:CASP3
gene id: 9597:CASP3
uniprot id: A0A2R9A7H9
names: Similarity
messages: Belongs to the peptidase C14A family.

9597:ZZZ3
gene id: 9597:ZZZ3
uniprot id: A0A2R9BW28
names: Subcellular Location Annotation
messages: Nucleus

9597:ZNF280C
gene id: 9597:ZNF280C
uniprot id: A0A2R8ZVK6
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9597:MEF2C
gene id: 9597:MEF2C
uniprot id: A0A2R9BUT3
names: Subcellular Location Annotation
messages: Nucleus

9597:INMT
gene id: 9597:INMT
uniprot id: A0A2R9C720
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9597:ENPEP
gene id: 9597:ENPEP
uniprot id: A0A2R9AL64
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9597:POLR2G
gene id: 9597:POLR2G
uniprot id: A0A2R9BWD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9597:ACOT13
gene id: 9597:ACOT13
uniprot id: A0A2R8ZZQ2
names: Similarity
messages: Belongs to the thioesterase PaaI family.

9597:RAB27A
gene id: 9597:RAB27A
uniprot id: A0A2R9ACB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9597:STX10
gene id: 9597:STX10
uniprot id: A0A2R9CA96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9597:PLCB2
gene id: 9597:PLCB2
uniprot id: A0A2R9BXS0
uniprot id: A0A2R9BYE2
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9597:MDN1
gene id: 9597:MDN1
uniprot id: A0A2R8Z9Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

9597:UGGT1
gene id: 9597:UGGT1
uniprot id: A0A2R9BTC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

9597:RPL18
gene id: 9597:RPL18
uniprot id: A0A2R8ZFU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Rough endoplasmic reticulum

9597:SRD5A2
gene id: 9597:SRD5A2
uniprot id: A0A2R9ANP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9597:BRINP1
gene id: 9597:BRINP1
uniprot id: A0A2R9AL02
names: Similarity
messages: Belongs to the BRINP family.

9597:TAS1R2
gene id: 9597:TAS1R2
uniprot id: A0A2R9CCZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9597:TGFB3
gene id: 9597:TGFB3
uniprot id: A0A2R9AJT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

9597:GATAD2A
gene id: 9597:GATAD2A
uniprot id: A0A2R8ZBD1
names: Subcellular Location Annotation
messages: Nucleus

9597:CDC42
gene id: 9597:CDC42
uniprot id: A0A2R9AF88
uniprot id: A0A2R9AG93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

9597:LOC100986229
gene id: 9597:LOC100986229
uniprot id: A0A2R9BFK9
uniprot id: A0A2R9CE22
uniprot id: A0A2R9CM92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome
messages: Nucleus

9597:LOC100976596
gene id: 9597:LOC100976596
uniprot id: A0A2R8ZCU1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9597:VAMP8
gene id: 9597:VAMP8
uniprot id: A0A2R9AJY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9597:PRIM1
gene id: 9597:PRIM1
uniprot id: A0A2R9B7A5
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9597:PHC2
gene id: 9597:PHC2
uniprot id: A0A2R8ZL28
names: Subcellular Location Annotation
messages: Nucleus

9597:FAM110C
gene id: 9597:FAM110C
uniprot id: A0A2R9AB80
names: Similarity
messages: Belongs to the FAM110 family.

9597:USP48
gene id: 9597:USP48
uniprot id: A0A2R9A2H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

9597:HOXC11
gene id: 9597:HOXC11
uniprot id: A0A2R9CK06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus